ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.54317080
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.18759745
3	response to pheromone (GO:0019236)	4.09187881
4	epithelial cilium movement (GO:0003351)	3.96077197
5	cilium or flagellum-dependent cell motility (GO:0001539)	3.87069411
6	protein polyglutamylation (GO:0018095)	3.79460454
7	axonemal dynein complex assembly (GO:0070286)	3.65336626
8	tryptophan catabolic process (GO:0006569)	3.63292976
9	indole-containing compound catabolic process (GO:0042436)	3.63292976
10	indolalkylamine catabolic process (GO:0046218)	3.63292976
11	detection of light stimulus involved in sensory perception (GO:0050962)	3.50607397
12	detection of light stimulus involved in visual perception (GO:0050908)	3.50607397
13	indolalkylamine metabolic process (GO:0006586)	3.49522083
14	sperm motility (GO:0030317)	3.48291691
15	pyrimidine nucleobase catabolic process (GO:0006208)	3.46831833
16	regulation of action potential (GO:0098900)	3.45068383
17	regulation of cilium movement (GO:0003352)	3.33837328
18	kynurenine metabolic process (GO:0070189)	3.30546852
19	cilium movement (GO:0003341)	3.29285644
20	synaptic transmission, cholinergic (GO:0007271)	3.23453603
21	neuronal action potential (GO:0019228)	3.18383551
22	postsynaptic membrane organization (GO:0001941)	3.17146575
23	neuron fate determination (GO:0048664)	3.15996967
24	tryptophan metabolic process (GO:0006568)	3.14815764
25	gamma-aminobutyric acid transport (GO:0015812)	3.14410163
26	dendritic spine morphogenesis (GO:0060997)	3.12535981
27	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.12154621
28	multicellular organism reproduction (GO:0032504)	3.11109835
29	L-fucose catabolic process (GO:0042355)	3.01327977
30	fucose catabolic process (GO:0019317)	3.01327977
31	L-fucose metabolic process (GO:0042354)	3.01327977
32	acrosome reaction (GO:0007340)	2.93579265
33	somite development (GO:0061053)	2.92200664
34	nucleobase catabolic process (GO:0046113)	2.91946126
35	axoneme assembly (GO:0035082)	2.91795384
36	cellular ketone body metabolic process (GO:0046950)	2.85523542
37	negative regulation of telomere maintenance (GO:0032205)	2.83124108
38	water-soluble vitamin biosynthetic process (GO:0042364)	2.82007844
39	DNA double-strand break processing (GO:0000729)	2.81909450
40	male meiosis (GO:0007140)	2.81226595
41	amine catabolic process (GO:0009310)	2.79911134
42	cellular biogenic amine catabolic process (GO:0042402)	2.79911134
43	spermatid development (GO:0007286)	2.79032689
44	protein-cofactor linkage (GO:0018065)	2.78937571
45	piRNA metabolic process (GO:0034587)	2.77826166
46	transmission of nerve impulse (GO:0019226)	2.76183662
47	photoreceptor cell maintenance (GO:0045494)	2.75155189
48	cilium morphogenesis (GO:0060271)	2.74381390
49	intraciliary transport (GO:0042073)	2.72762964
50	membrane depolarization during action potential (GO:0086010)	2.71938956
51	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.71633505
52	retinal ganglion cell axon guidance (GO:0031290)	2.71510545
53	positive regulation of action potential (GO:0045760)	2.70098572
54	microtubule severing (GO:0051013)	2.69227506
55	hindbrain development (GO:0030902)	2.67877159
56	resolution of meiotic recombination intermediates (GO:0000712)	2.67170457
57	regulation of microtubule-based movement (GO:0060632)	2.67057650
58	nonmotile primary cilium assembly (GO:0035058)	2.66993955
59	cell proliferation in forebrain (GO:0021846)	2.65445116
60	photoreceptor cell development (GO:0042461)	2.63813858
61	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.63377056
62	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.61961607
63	centriole replication (GO:0007099)	2.61687442
64	presynaptic membrane assembly (GO:0097105)	2.61348516
65	indole-containing compound metabolic process (GO:0042430)	2.59811155
66	DNA deamination (GO:0045006)	2.59026014
67	cilium organization (GO:0044782)	2.58373854
68	tongue development (GO:0043586)	2.57980623
69	protein neddylation (GO:0045116)	2.57400418
70	ketone body metabolic process (GO:1902224)	2.56816852
71	cilium assembly (GO:0042384)	2.56074687
72	DNA methylation involved in gamete generation (GO:0043046)	2.55499825
73	auditory behavior (GO:0031223)	2.54912381
74	positive regulation of gastrulation (GO:2000543)	2.54592871
75	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.53950470
76	rRNA catabolic process (GO:0016075)	2.51246395
77	neuron cell-cell adhesion (GO:0007158)	2.50820373
78	respiratory chain complex IV assembly (GO:0008535)	2.50626247
79	protein complex biogenesis (GO:0070271)	2.50566251
80	platelet dense granule organization (GO:0060155)	2.49831132
81	axon ensheathment in central nervous system (GO:0032291)	2.49193811
82	central nervous system myelination (GO:0022010)	2.49193811
83	reflex (GO:0060004)	2.49155726
84	action potential (GO:0001508)	2.47756271
85	presynaptic membrane organization (GO:0097090)	2.47555242
86	protein localization to synapse (GO:0035418)	2.47446706
87	seminiferous tubule development (GO:0072520)	2.46020098
88	replication fork processing (GO:0031297)	2.45746518
89	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.45550715
90	somite rostral/caudal axis specification (GO:0032525)	2.45030021
91	spinal cord development (GO:0021510)	2.44008094
92	cornea development in camera-type eye (GO:0061303)	2.41513351
93	neuronal action potential propagation (GO:0019227)	2.40398215
94	neuromuscular synaptic transmission (GO:0007274)	2.40209781
95	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.39657596
96	establishment of protein localization to Golgi (GO:0072600)	2.39101449
97	head development (GO:0060322)	2.38782143
98	regulation of posttranscriptional gene silencing (GO:0060147)	2.38636383
99	regulation of gene silencing by miRNA (GO:0060964)	2.38636383
100	regulation of gene silencing by RNA (GO:0060966)	2.38636383

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.18153416
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.36441202
3	VDR_22108803_ChIP-Seq_LS180_Human	3.31274359
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.72680221
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.69740039
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.58856979
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.50830783
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36493449
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.24966432
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.22143873
11	FUS_26573619_Chip-Seq_HEK293_Human	2.19774005
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.19195992
13	TAF15_26573619_Chip-Seq_HEK293_Human	1.98045863
14	P300_19829295_ChIP-Seq_ESCs_Human	1.92013323
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.91274314
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.87496906
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.86806539
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.85096904
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.84203190
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.81424684
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.79678582
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.78454239
23	EWS_26573619_Chip-Seq_HEK293_Human	1.71278185
24	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.66860972
25	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66860972
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.65179788
27	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62925851
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61170343
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60646056
30	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.60160428
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59121686
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.58947725
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58947725
34	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.58228261
35	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.57096825
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.51188693
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.51086544
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48783965
39	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.47443017
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42751278
41	STAT3_23295773_ChIP-Seq_U87_Human	1.42603157
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41868041
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40891461
44	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.40039399
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.38362695
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37940387
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37915248
48	AR_25329375_ChIP-Seq_VCAP_Human	1.37245126
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36595171
50	RUNX2_22187159_ChIP-Seq_PCA_Human	1.36053147
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35888500
52	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.35558018
53	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35123435
54	TCF4_23295773_ChIP-Seq_U87_Human	1.34730310
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.32330284
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32105685
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31131196
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.30658526
59	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.30204568
60	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.26321931
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.26273385
62	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.25312877
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23884320
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23713211
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.23430573
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22382473
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22382473
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18786289
69	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17827388
70	NCOR_22424771_ChIP-Seq_293T_Human	1.17740712
71	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.16936744
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16772235
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12689430
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12689430
75	MYC_18940864_ChIP-ChIP_HL60_Human	1.12410536
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11708668
77	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10134307
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09640634
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08855407
80	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.07640324
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07267368
82	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.05958716
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05940000
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04246230
85	AR_21572438_ChIP-Seq_LNCaP_Human	1.03995274
86	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.03847271
87	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03727113
88	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03214337
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02444314
90	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.01255646
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00960422
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.98593904
93	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98163218
94	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.97433772
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97362271
96	ERA_21632823_ChIP-Seq_H3396_Human	0.97324805
97	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.96615826
98	DROSHA_22980978_ChIP-Seq_HELA_Human	0.95494250
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.94953627
100	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.94933219

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	2.79119409
2	MP0008877_abnormal_DNA_methylation	2.78485700
3	MP0003787_abnormal_imprinting	2.77541345
4	MP0001968_abnormal_touch/_nociception	2.65344450
5	MP0002102_abnormal_ear_morphology	2.39185630
6	MP0001986_abnormal_taste_sensitivity	2.32823907
7	MP0005410_abnormal_fertilization	2.16684367
8	MP0002837_dystrophic_cardiac_calcinosis	2.15323245
9	MP0003122_maternal_imprinting	2.15271546
10	MP0005551_abnormal_eye_electrophysiolog	2.12439187
11	MP0004142_abnormal_muscle_tone	2.12120931
12	MP0004133_heterotaxia	1.99710229
13	MP0002736_abnormal_nociception_after	1.98820039
14	MP0003195_calcinosis	1.98452069
15	MP0009046_muscle_twitch	1.98159615
16	MP0003136_yellow_coat_color	1.97697458
17	MP0002272_abnormal_nervous_system	1.93721873
18	MP0010386_abnormal_urinary_bladder	1.92715544
19	MP0003646_muscle_fatigue	1.83573484
20	MP0009745_abnormal_behavioral_response	1.82536357
21	MP0006072_abnormal_retinal_apoptosis	1.81884739
22	MP0001485_abnormal_pinna_reflex	1.78203123
23	MP0006276_abnormal_autonomic_nervous	1.75530519
24	MP0002638_abnormal_pupillary_reflex	1.73014825
25	MP0003121_genomic_imprinting	1.66600589
26	MP0002653_abnormal_ependyma_morphology	1.59585712
27	MP0002735_abnormal_chemical_nociception	1.57148021
28	MP0005253_abnormal_eye_physiology	1.55482547
29	MP0004885_abnormal_endolymph	1.54173418
30	MP0000631_abnormal_neuroendocrine_gland	1.52778719
31	MP0002938_white_spotting	1.51332082
32	MP0001984_abnormal_olfaction	1.50747748
33	MP0003880_abnormal_central_pattern	1.49881460
34	MP0008872_abnormal_physiological_respon	1.49424352
35	MP0001529_abnormal_vocalization	1.49084606
36	MP0002160_abnormal_reproductive_system	1.46205209
37	MP0002557_abnormal_social/conspecific_i	1.45919852
38	MP0002572_abnormal_emotion/affect_behav	1.45650804
39	MP0003635_abnormal_synaptic_transmissio	1.45643859
40	MP0001486_abnormal_startle_reflex	1.45254986
41	MP0005423_abnormal_somatic_nervous	1.39862418
42	MP0001970_abnormal_pain_threshold	1.39645387
43	MP0003283_abnormal_digestive_organ	1.39423485
44	MP0002064_seizures	1.37000983
45	MP0002733_abnormal_thermal_nociception	1.35886877
46	MP0001501_abnormal_sleep_pattern	1.35533397
47	MP0002163_abnormal_gland_morphology	1.35222649
48	MP0005646_abnormal_pituitary_gland	1.33592048
49	MP0000778_abnormal_nervous_system	1.33275854
50	MP0002067_abnormal_sensory_capabilities	1.32774199
51	MP0000427_abnormal_hair_cycle	1.31422637
52	MP0004742_abnormal_vestibular_system	1.27455522
53	MP0000372_irregular_coat_pigmentation	1.27171448
54	MP0002063_abnormal_learning/memory/cond	1.24816127
55	MP0002234_abnormal_pharynx_morphology	1.24448701
56	MP0004924_abnormal_behavior	1.23963859
57	MP0005386_behavior/neurological_phenoty	1.23963859
58	MP0005084_abnormal_gallbladder_morpholo	1.23435036
59	MP0005645_abnormal_hypothalamus_physiol	1.23003202
60	MP0005389_reproductive_system_phenotype	1.20281636
61	MP0002734_abnormal_mechanical_nocicepti	1.17424104
62	MP0008875_abnormal_xenobiotic_pharmacok	1.17042960
63	MP0003698_abnormal_male_reproductive	1.15343443
64	MP0005377_hearing/vestibular/ear_phenot	1.14353844
65	MP0003878_abnormal_ear_physiology	1.14353844
66	MP0002184_abnormal_innervation	1.12273364
67	MP0002876_abnormal_thyroid_physiology	1.11713083
68	MP0001188_hyperpigmentation	1.11662396
69	MP0002752_abnormal_somatic_nervous	1.10605052
70	MP0000955_abnormal_spinal_cord	1.10520846
71	MP0002928_abnormal_bile_duct	1.09493121
72	MP0000026_abnormal_inner_ear	1.07505305
73	MP0003011_delayed_dark_adaptation	1.07412990
74	MP0005195_abnormal_posterior_eye	1.03840985
75	MP0000049_abnormal_middle_ear	1.03729859
76	MP0001905_abnormal_dopamine_level	1.02190225
77	MP0008789_abnormal_olfactory_epithelium	1.01690868
78	MP0000569_abnormal_digit_pigmentation	1.01509480
79	MP0003890_abnormal_embryonic-extraembry	1.00753005
80	MP0005379_endocrine/exocrine_gland_phen	1.00566331
81	MP0001929_abnormal_gametogenesis	0.99514744
82	MP0004145_abnormal_muscle_electrophysio	0.98317070
83	MP0002229_neurodegeneration	0.97906753
84	MP0004043_abnormal_pH_regulation	0.95393952
85	MP0008995_early_reproductive_senescence	0.94008984
86	MP0001293_anophthalmia	0.92371637
87	MP0002277_abnormal_respiratory_mucosa	0.92161830
88	MP0002882_abnormal_neuron_morphology	0.91734811
89	MP0001963_abnormal_hearing_physiology	0.91330089
90	MP0002138_abnormal_hepatobiliary_system	0.91121554
91	MP0004147_increased_porphyrin_level	0.90481944
92	MP0005394_taste/olfaction_phenotype	0.89847397
93	MP0005499_abnormal_olfactory_system	0.89847397
94	MP0002210_abnormal_sex_determination	0.88621141
95	MP0004859_abnormal_synaptic_plasticity	0.88256546
96	MP0001440_abnormal_grooming_behavior	0.88080622
97	MP0003252_abnormal_bile_duct	0.86093082
98	MP0002751_abnormal_autonomic_nervous	0.85061250
99	MP0003119_abnormal_digestive_system	0.83991783
100	MP0001919_abnormal_reproductive_system	0.82381316

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.46865041
2	Pancreatic fibrosis (HP:0100732)	4.46551382
3	True hermaphroditism (HP:0010459)	4.08001043
4	Abnormality of midbrain morphology (HP:0002418)	3.99419586
5	Molar tooth sign on MRI (HP:0002419)	3.99419586
6	Nephronophthisis (HP:0000090)	3.73228774
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.68992768
8	Type II lissencephaly (HP:0007260)	3.44554603
9	Congenital stationary night blindness (HP:0007642)	3.44191178
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.41481897
11	Chronic hepatic failure (HP:0100626)	3.31014009
12	Hyperventilation (HP:0002883)	3.26356186
13	Abnormality of the renal medulla (HP:0100957)	3.06524910
14	Pendular nystagmus (HP:0012043)	3.03856963
15	Cystic liver disease (HP:0006706)	2.97753511
16	Medial flaring of the eyebrow (HP:0010747)	2.92126944
17	Abnormal respiratory epithelium morphology (HP:0012253)	2.88625515
18	Abnormal respiratory motile cilium morphology (HP:0005938)	2.88625515
19	Abnormality of the renal cortex (HP:0011035)	2.82919014
20	Attenuation of retinal blood vessels (HP:0007843)	2.77927667
21	Abolished electroretinogram (ERG) (HP:0000550)	2.75282096
22	Absent/shortened dynein arms (HP:0200106)	2.75038632
23	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.75038632
24	Sclerocornea (HP:0000647)	2.59780303
25	Abnormal biliary tract physiology (HP:0012439)	2.59230005
26	Bile duct proliferation (HP:0001408)	2.59230005
27	Gait imbalance (HP:0002141)	2.57921548
28	Progressive cerebellar ataxia (HP:0002073)	2.56305277
29	Bony spicule pigmentary retinopathy (HP:0007737)	2.49758951
30	Lissencephaly (HP:0001339)	2.46986225
31	Atonic seizures (HP:0010819)	2.43705794
32	Optic nerve hypoplasia (HP:0000609)	2.42568586
33	Anencephaly (HP:0002323)	2.42077353
34	Decreased central vision (HP:0007663)	2.41136221
35	Cerebellar dysplasia (HP:0007033)	2.40968801
36	Abnormal ciliary motility (HP:0012262)	2.40488419
37	Congenital primary aphakia (HP:0007707)	2.36766987
38	Broad-based gait (HP:0002136)	2.36221213
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.35874009
40	Genetic anticipation (HP:0003743)	2.34915364
41	Tubular atrophy (HP:0000092)	2.34394348
42	Febrile seizures (HP:0002373)	2.33359003
43	Dialeptic seizures (HP:0011146)	2.32957480
44	Abnormal drinking behavior (HP:0030082)	2.32217630
45	Polydipsia (HP:0001959)	2.32217630
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.30593839
47	Increased corneal curvature (HP:0100692)	2.30447262
48	Keratoconus (HP:0000563)	2.30447262
49	Male pseudohermaphroditism (HP:0000037)	2.30124397
50	Abnormal respiratory motile cilium physiology (HP:0012261)	2.29361862
51	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.28844506
52	Postaxial foot polydactyly (HP:0001830)	2.27484454
53	Focal seizures (HP:0007359)	2.27054997
54	Absence seizures (HP:0002121)	2.23934377
55	Septo-optic dysplasia (HP:0100842)	2.20119737
56	Nephrogenic diabetes insipidus (HP:0009806)	2.19105389
57	Pachygyria (HP:0001302)	2.18308755
58	Inability to walk (HP:0002540)	2.17611390
59	Hypothermia (HP:0002045)	2.15002164
60	Renal cortical cysts (HP:0000803)	2.13899668
61	Protruding tongue (HP:0010808)	2.12569639
62	Asplenia (HP:0001746)	2.12182576
63	Abnormality of the labia minora (HP:0012880)	2.11230663
64	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.09506256
65	Congenital hepatic fibrosis (HP:0002612)	2.08573401
66	Myokymia (HP:0002411)	2.07759791
67	Gaze-evoked nystagmus (HP:0000640)	2.07467989
68	Abnormality of macular pigmentation (HP:0008002)	2.05227151
69	Genital tract atresia (HP:0001827)	2.01567066
70	Furrowed tongue (HP:0000221)	1.99359349
71	Abnormal number of erythroid precursors (HP:0012131)	1.97812874
72	Polyuria (HP:0000103)	1.96767371
73	Abnormality of DNA repair (HP:0003254)	1.96301420
74	Polyphagia (HP:0002591)	1.95875106
75	Vaginal atresia (HP:0000148)	1.95852978
76	Agitation (HP:0000713)	1.95274021
77	Abnormality of alanine metabolism (HP:0010916)	1.94092252
78	Hyperalaninemia (HP:0003348)	1.94092252
79	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.94092252
80	Retinal dysplasia (HP:0007973)	1.93061124
81	Drooling (HP:0002307)	1.92099967
82	Focal motor seizures (HP:0011153)	1.90168845
83	Occipital encephalocele (HP:0002085)	1.89278190
84	Abnormality of cells of the erythroid lineage (HP:0012130)	1.88953108
85	Postaxial hand polydactyly (HP:0001162)	1.86581583
86	Rib fusion (HP:0000902)	1.85512570
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.80727349
88	Hypoplasia of the pons (HP:0012110)	1.80161866
89	Abnormality of the pons (HP:0007361)	1.80068544
90	Anophthalmia (HP:0000528)	1.78249804
91	Increased CSF lactate (HP:0002490)	1.77557932
92	Methylmalonic aciduria (HP:0012120)	1.77412411
93	Retinitis pigmentosa (HP:0000510)	1.76738774
94	Supernumerary spleens (HP:0009799)	1.76409796
95	Disproportionate short-trunk short stature (HP:0003521)	1.76070077
96	Constricted visual fields (HP:0001133)	1.73524947
97	Acute necrotizing encephalopathy (HP:0006965)	1.71781178
98	Mitochondrial inheritance (HP:0001427)	1.71176571
99	Bilateral microphthalmos (HP:0007633)	1.70725288
100	Congenital sensorineural hearing impairment (HP:0008527)	1.70004785

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.67072516
2	PINK1	3.56194211
3	CASK	3.39579198
4	MAP4K2	3.07897217
5	ADRBK2	2.92026219
6	STK16	2.70309027
7	WNK4	2.64151161
8	NUAK1	2.43232171
9	INSRR	2.37315524
10	WNK3	2.37014202
11	ZAK	2.27400054
12	GRK1	2.26946661
13	TLK1	2.20738716
14	MAP3K4	2.16003507
15	CDK19	1.99620375
16	MARK1	1.93450173
17	DYRK2	1.84905467
18	MAPK13	1.84527900
19	BMPR1B	1.79123370
20	MAP2K7	1.59464272
21	TAOK3	1.56764034
22	PNCK	1.45769133
23	STK39	1.42272901
24	OXSR1	1.27340592
25	PRKCG	1.21580397
26	VRK1	1.17514380
27	TNIK	1.15668439
28	DAPK2	1.15666693
29	NTRK3	1.10548487
30	PLK4	1.04182355
31	PHKG1	1.01503138
32	PHKG2	1.01503138
33	MARK3	0.99986225
34	PLK2	0.97979271
35	PAK3	0.96693973
36	EPHA4	0.96423653
37	TRIM28	0.95611124
38	ADRBK1	0.94145781
39	PRKCE	0.92347634
40	TIE1	0.88487751
41	MKNK2	0.86572170
42	PIK3CA	0.86064888
43	TXK	0.82526429
44	VRK2	0.80577957
45	NTRK2	0.79587922
46	BCKDK	0.76554505
47	SGK223	0.76319423
48	SGK494	0.76319423
49	PRKCQ	0.74655181
50	TAF1	0.73009790
51	CSNK1G2	0.71437818
52	CAMK1G	0.69817669
53	DYRK3	0.68881750
54	EIF2AK3	0.68865527
55	CAMK1	0.68482305
56	SGK2	0.68341572
57	RPS6KA5	0.66521886
58	PRKD3	0.62020370
59	CSNK1G3	0.61060893
60	MAP3K9	0.60301433
61	CSNK1G1	0.60123312
62	SIK2	0.56352176
63	NEK2	0.55975027
64	CSNK1A1L	0.55599753
65	CAMKK2	0.53058915
66	PLK3	0.52542363
67	DYRK1A	0.52257271
68	PRKACA	0.52234874
69	PRKG1	0.51284924
70	STK11	0.51096947
71	STK3	0.51080722
72	MAPK15	0.51024507
73	CSNK1A1	0.50268276
74	CAMK2A	0.49986417
75	ACVR1B	0.49487416
76	GRK7	0.46341612
77	PRKCZ	0.45214854
78	TYRO3	0.44879532
79	PKN1	0.44022374
80	SGK1	0.43923183
81	TGFBR1	0.43587114
82	CAMK1D	0.43312271
83	WNK1	0.41032903
84	OBSCN	0.40728683
85	EPHB2	0.39244506
86	MAPKAPK5	0.38565076
87	STK38L	0.37091681
88	CDK5	0.37058446
89	BCR	0.35970543
90	CDK3	0.34411871
91	ERBB3	0.34362880
92	GRK5	0.34326174
93	MINK1	0.33322805
94	PRKCA	0.32599771
95	CAMK4	0.32553290
96	FGFR2	0.32299163
97	PRKAA1	0.31880645
98	AKT3	0.30380569
99	MKNK1	0.29436897
100	MAP2K4	0.29061223

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.85594564
2	Nicotine addiction_Homo sapiens_hsa05033	2.82934099
3	Butanoate metabolism_Homo sapiens_hsa00650	2.56941568
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.56058024
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.53484479
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.51027982
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.40120789
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.35918263
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.12190893
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.01609574
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.00143733
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.99551232
13	Olfactory transduction_Homo sapiens_hsa04740	1.87813509
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.81052622
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.80892705
16	Parkinsons disease_Homo sapiens_hsa05012	1.79582069
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.78078781
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.74102040
19	Propanoate metabolism_Homo sapiens_hsa00640	1.68699987
20	Taste transduction_Homo sapiens_hsa04742	1.60695377
21	Basal transcription factors_Homo sapiens_hsa03022	1.60490768
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.57137638
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55709540
24	Morphine addiction_Homo sapiens_hsa05032	1.53302881
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.52347284
26	Caffeine metabolism_Homo sapiens_hsa00232	1.47191109
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.45905110
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.43367707
29	Homologous recombination_Homo sapiens_hsa03440	1.42306178
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.42010867
31	GABAergic synapse_Homo sapiens_hsa04727	1.41242828
32	RNA degradation_Homo sapiens_hsa03018	1.38282467
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.34521485
34	Insulin secretion_Homo sapiens_hsa04911	1.31064944
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.27759658
36	Protein export_Homo sapiens_hsa03060	1.26957441
37	Huntingtons disease_Homo sapiens_hsa05016	1.26740763
38	Glutamatergic synapse_Homo sapiens_hsa04724	1.26599445
39	Steroid biosynthesis_Homo sapiens_hsa00100	1.25142888
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.24228270
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.22113029
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20986553
43	Circadian entrainment_Homo sapiens_hsa04713	1.17753453
44	Alzheimers disease_Homo sapiens_hsa05010	1.16599226
45	RNA polymerase_Homo sapiens_hsa03020	1.15183989
46	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10612733
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08391397
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04242723
49	Peroxisome_Homo sapiens_hsa04146	1.03961564
50	Retinol metabolism_Homo sapiens_hsa00830	1.00396366
51	Ribosome_Homo sapiens_hsa03010	1.00023090
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.99533936
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.97401487
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93751720
55	Serotonergic synapse_Homo sapiens_hsa04726	0.92519996
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.86835129
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86622946
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.86327253
59	ABC transporters_Homo sapiens_hsa02010	0.85065964
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84304091
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77142616
62	Calcium signaling pathway_Homo sapiens_hsa04020	0.73827370
63	Regulation of autophagy_Homo sapiens_hsa04140	0.72780956
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.72454328
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.71171831
66	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.68174842
67	Cholinergic synapse_Homo sapiens_hsa04725	0.65652712
68	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.64633539
69	Salivary secretion_Homo sapiens_hsa04970	0.63716146
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62599793
71	Purine metabolism_Homo sapiens_hsa00230	0.60548374
72	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.60303166
73	Cocaine addiction_Homo sapiens_hsa05030	0.59465693
74	Metabolic pathways_Homo sapiens_hsa01100	0.59384503
75	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.58252388
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56493311
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.55445705
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52487990
79	Axon guidance_Homo sapiens_hsa04360	0.51333633
80	Gastric acid secretion_Homo sapiens_hsa04971	0.51268448
81	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.50126196
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49292564
83	Histidine metabolism_Homo sapiens_hsa00340	0.48832443
84	Non-homologous end-joining_Homo sapiens_hsa03450	0.48103905
85	Fatty acid degradation_Homo sapiens_hsa00071	0.47747350
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.47216159
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45331982
88	Long-term depression_Homo sapiens_hsa04730	0.43444367
89	Amphetamine addiction_Homo sapiens_hsa05031	0.43197853
90	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.43139923
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.42754729
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.41426537
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.37582170
94	One carbon pool by folate_Homo sapiens_hsa00670	0.37432621
95	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37015070
96	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.36296706
97	Gap junction_Homo sapiens_hsa04540	0.35395913
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.34511932
99	Mineral absorption_Homo sapiens_hsa04978	0.34330713
100	Nucleotide excision repair_Homo sapiens_hsa03420	0.32803475

RSU1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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