RSU1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1myofibril assembly (GO:0030239)5.54743756
2muscle cell cellular homeostasis (GO:0046716)5.41592827
3response to muscle activity (GO:0014850)5.40539762
4relaxation of smooth muscle (GO:0044557)5.33542112
5cGMP-mediated signaling (GO:0019934)4.94667238
6mesenchymal-epithelial cell signaling (GO:0060638)4.94452093
7fibroblast migration (GO:0010761)4.77723034
8sarcomere organization (GO:0045214)4.76358706
9muscle filament sliding (GO:0030049)4.74180095
10actin-myosin filament sliding (GO:0033275)4.74180095
11actin-mediated cell contraction (GO:0070252)4.72910180
12regulation of relaxation of muscle (GO:1901077)4.69987496
13relaxation of muscle (GO:0090075)4.30137986
14regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.23767889
15cellular response to zinc ion (GO:0071294)4.22504985
16negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.19549481
17regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.17355289
18coenzyme catabolic process (GO:0009109)4.15290365
19cellular response to interferon-alpha (GO:0035457)4.04055743
20ovulation cycle (GO:0042698)4.02913946
21positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.02714519
22cardiac myofibril assembly (GO:0055003)3.92491468
23muscle fiber development (GO:0048747)3.81537307
24positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.74891585
25urinary tract smooth muscle contraction (GO:0014848)3.70785112
26regulation of skeletal muscle contraction (GO:0014819)3.68250203
27actin filament-based movement (GO:0030048)3.62908355
28activation of protein kinase B activity (GO:0032148)3.61620371
29regulation of myoblast differentiation (GO:0045661)3.61580880
30neuron projection extension involved in neuron projection guidance (GO:1902284)3.59153782
31axon extension involved in axon guidance (GO:0048846)3.59153782
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.56917583
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.48506181
34protein localization to cell surface (GO:0034394)3.46870556
35ganglion development (GO:0061548)3.43668324
36DNA integration (GO:0015074)3.38394137
37dermatan sulfate biosynthetic process (GO:0030208)3.37962627
38positive regulation of catecholamine secretion (GO:0033605)3.37685695
39regulation of oxidative phosphorylation (GO:0002082)3.37603405
40positive regulation of cardiac muscle hypertrophy (GO:0010613)3.35159628
41positive regulation of muscle hypertrophy (GO:0014742)3.35159628
42aggressive behavior (GO:0002118)3.30810849
43potassium ion import (GO:0010107)3.30634283
44cardiac muscle hypertrophy (GO:0003300)3.29905258
45regulation of oxidative stress-induced neuron death (GO:1903203)3.29457213
46regulation of cell communication by electrical coupling (GO:0010649)3.26601294
47actomyosin structure organization (GO:0031032)3.26163817
48regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20994171
49paraxial mesoderm development (GO:0048339)3.20978768
50response to inactivity (GO:0014854)3.19221249
51muscle contraction (GO:0006936)3.17797189
52adult heart development (GO:0007512)3.16655241
53striated muscle hypertrophy (GO:0014897)3.16386017
54glucocorticoid biosynthetic process (GO:0006704)3.13314875
55response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.08667473
56relaxation of cardiac muscle (GO:0055119)3.08032353
57muscle system process (GO:0003012)3.07304467
58regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.06746520
59negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06353721
60cellular response to cadmium ion (GO:0071276)3.02081694
61peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.00350585
62cGMP metabolic process (GO:0046068)3.00302861
63plasma membrane repair (GO:0001778)2.99841356
64regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.99354960
65arginine catabolic process (GO:0006527)2.97701671
66regulation of cardiac muscle hypertrophy (GO:0010611)2.96597227
67lymphangiogenesis (GO:0001946)2.94829149
68negative regulation of muscle contraction (GO:0045932)2.94709982
69negative regulation of striated muscle cell apoptotic process (GO:0010664)2.93597132
70regulation of skeletal muscle fiber development (GO:0048742)2.92538828
71dermatan sulfate metabolic process (GO:0030205)2.91866554
72lateral sprouting from an epithelium (GO:0060601)2.90762481
73smooth muscle tissue development (GO:0048745)2.90483021
74regulation of muscle hypertrophy (GO:0014743)2.87847816
75regulation of phosphoprotein phosphatase activity (GO:0043666)2.85117383
76retina vasculature morphogenesis in camera-type eye (GO:0061299)2.84731394
77musculoskeletal movement (GO:0050881)2.84649674
78multicellular organismal movement (GO:0050879)2.84649674
79muscle cell fate commitment (GO:0042693)2.83164593
80motile cilium assembly (GO:0044458)2.77422363
81cGMP biosynthetic process (GO:0006182)2.73124198
82muscle hypertrophy (GO:0014896)2.72562200
83sarcoplasmic reticulum calcium ion transport (GO:0070296)2.72161253
84positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.67113968
85regulation of muscle adaptation (GO:0043502)2.66645001
86ADP metabolic process (GO:0046031)2.66186085
87regulation of phospholipase A2 activity (GO:0032429)2.65902337
88negative regulation of homotypic cell-cell adhesion (GO:0034111)2.65038841
89AMP metabolic process (GO:0046033)2.62110135
90myotube cell development (GO:0014904)2.61254617
91smooth muscle cell differentiation (GO:0051145)2.60998067
92positive regulation of myoblast differentiation (GO:0045663)2.59921277
93otic vesicle formation (GO:0030916)2.59298615
94skeletal muscle tissue development (GO:0007519)2.56991267
95striated muscle cell development (GO:0055002)2.55566995
96kidney morphogenesis (GO:0060993)2.53874591
97regulation of keratinocyte proliferation (GO:0010837)2.52320491
98smooth muscle contraction (GO:0006939)2.51289472
99regulation of transforming growth factor beta2 production (GO:0032909)2.51175140
100cofactor catabolic process (GO:0051187)2.48545095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.60167318
2GBX2_23144817_ChIP-Seq_PC3_Human4.43889266
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.95922151
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89650737
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.78673092
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43479817
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.43269822
8VDR_22108803_ChIP-Seq_LS180_Human2.42199451
9EZH2_22144423_ChIP-Seq_EOC_Human2.40593469
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34654496
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.26887782
12PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.21106557
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14235939
14FUS_26573619_Chip-Seq_HEK293_Human2.11225174
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07425764
16TAF15_26573619_Chip-Seq_HEK293_Human2.01469347
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99406637
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.96511343
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96129750
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.90962707
21P300_19829295_ChIP-Seq_ESCs_Human1.90643683
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.86926385
23SMAD4_21799915_ChIP-Seq_A2780_Human1.86288263
24AR_21572438_ChIP-Seq_LNCaP_Human1.84430542
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82190462
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77470656
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.77352227
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76306484
29BCAT_22108803_ChIP-Seq_LS180_Human1.69341841
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68796731
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.65929723
32TP53_16413492_ChIP-PET_HCT116_Human1.65737539
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64698702
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64620858
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64270502
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64270502
37EWS_26573619_Chip-Seq_HEK293_Human1.63794626
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62501810
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58607309
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57468690
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54990882
42CJUN_26792858_Chip-Seq_BT549_Human1.54245974
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53870281
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53781141
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53059522
46TP53_18474530_ChIP-ChIP_U2OS_Human1.50929687
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50587795
48IGF1R_20145208_ChIP-Seq_DFB_Human1.46865832
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.46117920
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41634622
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41409800
52TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.41003727
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38691480
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38444400
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.38280413
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37454824
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36403310
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34648222
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34648222
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34173783
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33256551
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33256551
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31583321
64ER_23166858_ChIP-Seq_MCF-7_Human1.31436040
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31429860
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30909016
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28411979
68CBP_20019798_ChIP-Seq_JUKART_Human1.28411979
69AR_25329375_ChIP-Seq_VCAP_Human1.28049350
70STAT3_23295773_ChIP-Seq_U87_Human1.27689083
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25948101
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24560053
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.24322497
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22924984
75TCF4_23295773_ChIP-Seq_U87_Human1.22000602
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.21005697
77RXR_22108803_ChIP-Seq_LS180_Human1.18767579
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15910316
79ZNF274_21170338_ChIP-Seq_K562_Hela1.15569336
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.15462493
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13217834
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11667904
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.11526598
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10165670
85BRD4_25478319_ChIP-Seq_HGPS_Human1.09669910
86TBL1_22424771_ChIP-Seq_293T_Human1.09057422
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.08951506
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.08750543
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08723581
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.08399925
91AHR_22903824_ChIP-Seq_MCF-7_Human1.08307847
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.06722951
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05482720
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04434000
95MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04153488
96RUNX2_22187159_ChIP-Seq_PCA_Human1.02676441
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02286410
98RNF2_27304074_Chip-Seq_ESCs_Mouse1.02206764
99TCF4_22108803_ChIP-Seq_LS180_Human1.02023275
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01718202

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration5.00359872
2MP0004084_abnormal_cardiac_muscle4.08910570
3MP0002837_dystrophic_cardiac_calcinosis3.81992586
4MP0004036_abnormal_muscle_relaxation3.63562119
5MP0004215_abnormal_myocardial_fiber2.96781742
6MP0004145_abnormal_muscle_electrophysio2.90144958
7MP0005620_abnormal_muscle_contractility2.47625040
8MP0002108_abnormal_muscle_morphology2.46152611
9MP0004272_abnormal_basement_membrane2.37083883
10MP0010368_abnormal_lymphatic_system2.23802986
11MP0001299_abnormal_eye_distance/2.22438489
12MP0003806_abnormal_nucleotide_metabolis2.20937394
13MP0009697_abnormal_copulation2.16279087
14MP0005187_abnormal_penis_morphology2.12401875
15MP0003136_yellow_coat_color2.11278179
16MP0008004_abnormal_stomach_pH2.05588629
17MP0008438_abnormal_cutaneous_collagen2.05228274
18MP0000751_myopathy2.00098840
19MP0005503_abnormal_tendon_morphology1.92596426
20MP0005330_cardiomyopathy1.88373962
21MP0005275_abnormal_skin_tensile1.88110597
22MP0002269_muscular_atrophy1.87288727
23MP0002638_abnormal_pupillary_reflex1.86321000
24MP0003950_abnormal_plasma_membrane1.84097669
25MP0001485_abnormal_pinna_reflex1.77501327
26MP0003646_muscle_fatigue1.77170240
27MP0002127_abnormal_cardiovascular_syste1.74944016
28MP0010386_abnormal_urinary_bladder1.70113704
29MP0002102_abnormal_ear_morphology1.65936092
30MP0004087_abnormal_muscle_fiber1.64251594
31MP0005623_abnormal_meninges_morphology1.64119904
32MP0003941_abnormal_skin_development1.62021157
33MP0005595_abnormal_vascular_smooth1.57451474
34MP0001661_extended_life_span1.55042948
35MP0005369_muscle_phenotype1.52992876
36MP0001984_abnormal_olfaction1.52048199
37MP0006072_abnormal_retinal_apoptosis1.49992500
38MP0005248_abnormal_Harderian_gland1.46833546
39MP0008775_abnormal_heart_ventricle1.46582284
40MP0003385_abnormal_body_wall1.45874962
41MP0009780_abnormal_chondrocyte_physiolo1.44277053
42MP0000759_abnormal_skeletal_muscle1.40895260
43MP0003879_abnormal_hair_cell1.40740297
44MP0000767_abnormal_smooth_muscle1.37796716
45MP0000013_abnormal_adipose_tissue1.37404452
46MP0004270_analgesia1.37189134
47MP0000534_abnormal_ureter_morphology1.37156397
48MP0009250_abnormal_appendicular_skeleto1.34383909
49MP0000566_synostosis1.33970070
50MP0001188_hyperpigmentation1.32226375
51MP0002106_abnormal_muscle_physiology1.32114255
52MP0004085_abnormal_heartbeat1.31146373
53MP0004510_myositis1.30918109
54MP0001879_abnormal_lymphatic_vessel1.30096750
55MP0000747_muscle_weakness1.25427162
56MP0005385_cardiovascular_system_phenoty1.24913264
57MP0001544_abnormal_cardiovascular_syste1.24913264
58MP0000750_abnormal_muscle_regeneration1.22133294
59MP0005646_abnormal_pituitary_gland1.20818862
60MP0004484_altered_response_of1.19459108
61MP0002972_abnormal_cardiac_muscle1.18779843
62MP0002160_abnormal_reproductive_system1.11539055
63MP0002822_catalepsy1.06171108
64MP0010030_abnormal_orbit_morphology1.05515610
65MP0003942_abnormal_urinary_system1.02546451
66MP0000230_abnormal_systemic_arterial1.01539234
67MP0006138_congestive_heart_failure0.96092943
68MP0003315_abnormal_perineum_morphology0.95096601
69MP0002751_abnormal_autonomic_nervous0.95035368
70MP0000049_abnormal_middle_ear0.90995072
71MP0005171_absent_coat_pigmentation0.90878764
72MP0008789_abnormal_olfactory_epithelium0.90407128
73MP0002233_abnormal_nose_morphology0.88932559
74MP0005253_abnormal_eye_physiology0.87889631
75MP0000762_abnormal_tongue_morphology0.86074287
76MP0001440_abnormal_grooming_behavior0.85749477
77MP0002272_abnormal_nervous_system0.85293202
78MP0002132_abnormal_respiratory_system0.84608419
79MP0000733_abnormal_muscle_development0.84142015
80MP0002295_abnormal_pulmonary_circulatio0.83658437
81MP0001664_abnormal_digestion0.82768910
82MP0010630_abnormal_cardiac_muscle0.82049822
83MP0005508_abnormal_skeleton_morphology0.80804048
84MP0004742_abnormal_vestibular_system0.80796647
85MP0000026_abnormal_inner_ear0.79904746
86MP0002128_abnormal_blood_circulation0.78902229
87MP0004134_abnormal_chest_morphology0.78707463
88MP0000631_abnormal_neuroendocrine_gland0.78227860
89MP0001486_abnormal_startle_reflex0.77969374
90MP0009046_muscle_twitch0.77558298
91MP0003868_abnormal_feces_composition0.74747837
92MP0003890_abnormal_embryonic-extraembry0.73053880
93MP0001177_atelectasis0.72673190
94MP0000538_abnormal_urinary_bladder0.72134341
95MP0003755_abnormal_palate_morphology0.71231698
96MP0005499_abnormal_olfactory_system0.69058341
97MP0005394_taste/olfaction_phenotype0.69058341
98MP0002090_abnormal_vision0.68828655
99MP0006054_spinal_hemorrhage0.66293600
100MP0003137_abnormal_impulse_conducting0.63505289

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.87396218
2Muscle fiber inclusion bodies (HP:0100299)6.55496822
3Nemaline bodies (HP:0003798)6.22702642
4Hyporeflexia of lower limbs (HP:0002600)5.93272685
5Aortic aneurysm (HP:0004942)4.84541184
6Abnormality of the calf musculature (HP:0001430)4.74722776
7Type 1 muscle fiber predominance (HP:0003803)4.36047335
8Calf muscle hypertrophy (HP:0008981)4.35535412
9Sensory axonal neuropathy (HP:0003390)4.31780834
10Rimmed vacuoles (HP:0003805)4.30716851
11Exercise-induced myalgia (HP:0003738)4.23720539
12Exercise-induced muscle cramps (HP:0003710)4.12526540
13Muscle hypertrophy of the lower extremities (HP:0008968)4.11835308
14EMG: myopathic abnormalities (HP:0003458)3.99435835
15Neck muscle weakness (HP:0000467)3.62133454
16Scapular winging (HP:0003691)3.55455847
17Clumsiness (HP:0002312)3.42067653
18Proximal amyotrophy (HP:0007126)3.29279641
19Abnormality of the shoulder girdle musculature (HP:0001435)3.26682561
20Muscle fiber splitting (HP:0003555)3.24618918
21Distal arthrogryposis (HP:0005684)3.22735706
22Sudden death (HP:0001699)3.10995640
23Centrally nucleated skeletal muscle fibers (HP:0003687)2.94540015
24Muscular dystrophy (HP:0003560)2.94529845
25Popliteal pterygium (HP:0009756)2.91809240
26Spinal rigidity (HP:0003306)2.91752735
27Increased variability in muscle fiber diameter (HP:0003557)2.88954904
28Steppage gait (HP:0003376)2.78613849
29Dysmetric saccades (HP:0000641)2.76520296
30Frequent falls (HP:0002359)2.74907335
31Axonal loss (HP:0003447)2.69484060
32Difficulty running (HP:0009046)2.56495238
33Myoglobinuria (HP:0002913)2.50388724
34Atonic seizures (HP:0010819)2.46593967
35Abnormality of skeletal muscle fiber size (HP:0012084)2.45253969
36Aplasia/Hypoplasia of the tibia (HP:0005772)2.37759990
37Short tibia (HP:0005736)2.35156930
38Areflexia of lower limbs (HP:0002522)2.34194138
39Malignant hyperthermia (HP:0002047)2.33552090
40Right ventricular cardiomyopathy (HP:0011663)2.30492489
41Hypoventilation (HP:0002791)2.24270657
42Dilated cardiomyopathy (HP:0001644)2.23715666
43Lipoatrophy (HP:0100578)2.23682294
44Aortic dissection (HP:0002647)2.23290889
45Resting tremor (HP:0002322)2.22713161
46Septo-optic dysplasia (HP:0100842)2.22046296
47Reduced antithrombin III activity (HP:0001976)2.20107449
48Bulbar palsy (HP:0001283)2.18559230
49Abnormality of the columella (HP:0009929)2.15881349
50Myopathic facies (HP:0002058)2.13167438
51Short hallux (HP:0010109)2.09092185
52Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.08923171
53Facial diplegia (HP:0001349)2.05952060
54Spinal cord lesions (HP:0100561)2.02923934
55Syringomyelia (HP:0003396)2.02923934
56Limited hip movement (HP:0008800)2.02871608
57Broad metatarsal (HP:0001783)2.00000473
58Preaxial foot polydactyly (HP:0001841)1.98238458
59Respiratory insufficiency due to muscle weakness (HP:0002747)1.97614046
60Broad-based gait (HP:0002136)1.97352056
61Knee flexion contracture (HP:0006380)1.96679416
62Malnutrition (HP:0004395)1.96166394
63Gaze-evoked nystagmus (HP:0000640)1.94989912
64Abnormality of the frontal sinuses (HP:0002687)1.94400566
65Abnormality of incisor morphology (HP:0011063)1.93596286
66Aplasia/Hypoplasia of the hallux (HP:0008362)1.92469619
67Foot dorsiflexor weakness (HP:0009027)1.91413260
68Rhabdomyolysis (HP:0003201)1.88967042
69Abnormality of the foot musculature (HP:0001436)1.88577603
70Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.87431148
71Osteolytic defects of the hand bones (HP:0009699)1.87239623
72Osteolytic defects of the phalanges of the hand (HP:0009771)1.87239623
73Abnormality of the ischium (HP:0003174)1.86502567
74Prolonged QT interval (HP:0001657)1.84739430
75Scanning speech (HP:0002168)1.83793039
76Ectopia lentis (HP:0001083)1.82465276
77Hypothermia (HP:0002045)1.81113595
78Broad ribs (HP:0000885)1.81093206
79Ventricular fibrillation (HP:0001663)1.79656977
80Optic nerve hypoplasia (HP:0000609)1.79628050
81Abnormality of the incisor (HP:0000676)1.78141274
82Atrial fibrillation (HP:0005110)1.77736235
83Action tremor (HP:0002345)1.77446936
84Postural instability (HP:0002172)1.77096657
85Median cleft lip (HP:0000161)1.75733181
86Eosinophilia (HP:0001880)1.72737838
87Bifid tongue (HP:0010297)1.69490534
88Generalized muscle weakness (HP:0003324)1.67935430
89Myotonia (HP:0002486)1.63213727
90Central scotoma (HP:0000603)1.61826524
91Long clavicles (HP:0000890)1.58712540
92Depressed nasal tip (HP:0000437)1.58276592
93Overgrowth (HP:0001548)1.56700322
94Rhinitis (HP:0012384)1.56632644
95Febrile seizures (HP:0002373)1.53695457
96Weak cry (HP:0001612)1.53097353
97Progressive cerebellar ataxia (HP:0002073)1.53057123
98Syncope (HP:0001279)1.52767184
99Midline defect of the nose (HP:0004122)1.51772476
100Truncal ataxia (HP:0002078)1.51369051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.77911822
2PINK16.07665592
3TNIK4.36301298
4LATS13.05316704
5MYLK3.00266697
6STK38L2.83142254
7AKT32.65372196
8PNCK2.26070930
9FRK2.19706415
10PHKG22.12034994
11PHKG12.12034994
12MAP3K102.11990902
13MARK32.09488897
14IRAK21.83526960
15DDR21.72515817
16PAK31.69661969
17BMPR1B1.67019392
18DMPK1.48198008
19MELK1.47682689
20WNK31.41576218
21TGFBR11.25656320
22PAK21.24467826
23NLK1.20509414
24MAPK121.19777839
25SGK21.14843875
26MAP2K71.14170466
27TIE11.10425817
28GRK51.09938184
29SGK4941.07566656
30SGK2231.07566656
31MAPK131.06464879
32LATS21.03389535
33MUSK1.02868354
34ROCK10.99884762
35PRKG20.98329534
36NEK20.92058953
37STK30.89442930
38LIMK10.88977722
39CDK80.82799941
40RPS6KB10.82717936
41PKN10.77917450
42TTN0.77542704
43PRKG10.76799619
44NUAK10.76777780
45STK390.73919266
46TLK10.70348819
47CCNB10.67219600
48STK380.65371785
49CSNK1A1L0.64686373
50PDGFRB0.63431762
51EIF2AK30.61363186
52STK240.60535478
53PBK0.59922102
54MAPKAPK30.58072517
55ILK0.56818942
56OXSR10.55729293
57PTK2B0.53064770
58MARK10.51098150
59MAP3K70.50634907
60SGK30.50534494
61CSNK1G10.49811200
62ACVR1B0.49699510
63CAMK2D0.47489946
64MAPK150.47397949
65STK160.44896034
66PIK3CA0.43020899
67PDGFRA0.42465333
68MINK10.42050471
69PIK3CG0.40456729
70PRKCQ0.38626297
71WEE10.37905614
72DAPK30.37617734
73VRK10.37569212
74PRKACB0.37254438
75CASK0.37101831
76ADRBK10.36935325
77PRKAA10.36425814
78CSNK1G20.36096647
79ZAK0.35538937
80FGFR20.35429694
81GRK10.35043855
82ABL20.34862947
83ROCK20.34498041
84NTRK20.33870795
85MAP3K40.32433281
86CDK30.31562676
87PRKACA0.30528885
88RAF10.29675614
89CLK10.28899044
90CAMK2G0.28622413
91AKT20.28480233
92MKNK20.27433671
93CSNK1G30.26749118
94PRKCE0.26466294
95TGFBR20.26121682
96PRKD30.23808401
97RET0.23799390
98GSK3A0.23579493
99BRD40.23458459
100CDK50.23381769

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.13031257
2Dilated cardiomyopathy_Homo sapiens_hsa054142.97052434
3Vascular smooth muscle contraction_Homo sapiens_hsa042702.71625783
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.70554819
5Vitamin B6 metabolism_Homo sapiens_hsa007502.52227653
6cGMP-PKG signaling pathway_Homo sapiens_hsa040222.29195133
7Nitrogen metabolism_Homo sapiens_hsa009102.27145439
8Olfactory transduction_Homo sapiens_hsa047402.18549439
9Sulfur relay system_Homo sapiens_hsa041222.08099885
10Cardiac muscle contraction_Homo sapiens_hsa042602.06220409
11ECM-receptor interaction_Homo sapiens_hsa045122.03583581
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94089930
13Calcium signaling pathway_Homo sapiens_hsa040201.89887843
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.85290045
15Circadian rhythm_Homo sapiens_hsa047101.81388312
16Circadian entrainment_Homo sapiens_hsa047131.78731827
17Oxytocin signaling pathway_Homo sapiens_hsa049211.64479699
18Renin secretion_Homo sapiens_hsa049241.64336982
19Salivary secretion_Homo sapiens_hsa049701.63503709
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62576740
21Focal adhesion_Homo sapiens_hsa045101.60373896
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59852007
23Gastric acid secretion_Homo sapiens_hsa049711.57025865
24Gap junction_Homo sapiens_hsa045401.55299949
25GABAergic synapse_Homo sapiens_hsa047271.54575796
26TGF-beta signaling pathway_Homo sapiens_hsa043501.54559193
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.44451917
28Folate biosynthesis_Homo sapiens_hsa007901.43783836
29Chemical carcinogenesis_Homo sapiens_hsa052041.37345322
30Mineral absorption_Homo sapiens_hsa049781.37342167
31Taste transduction_Homo sapiens_hsa047421.37126238
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35407245
33Melanoma_Homo sapiens_hsa052181.28933750
34Parkinsons disease_Homo sapiens_hsa050121.27681788
35Long-term depression_Homo sapiens_hsa047301.25624937
36Dorso-ventral axis formation_Homo sapiens_hsa043201.14278284
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12277001
38Alzheimers disease_Homo sapiens_hsa050101.11813617
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11634103
40Pancreatic secretion_Homo sapiens_hsa049721.06964910
41Glutamatergic synapse_Homo sapiens_hsa047241.02643680
42Platelet activation_Homo sapiens_hsa046110.97815225
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96902278
44Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96882242
45Oxidative phosphorylation_Homo sapiens_hsa001900.96128436
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95770401
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93829953
48Morphine addiction_Homo sapiens_hsa050320.89957484
49Protein digestion and absorption_Homo sapiens_hsa049740.89589702
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88598131
51Insulin secretion_Homo sapiens_hsa049110.87068400
52Tight junction_Homo sapiens_hsa045300.86666533
53Serotonergic synapse_Homo sapiens_hsa047260.86191268
54cAMP signaling pathway_Homo sapiens_hsa040240.84094893
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83944629
56Melanogenesis_Homo sapiens_hsa049160.83307735
57Adherens junction_Homo sapiens_hsa045200.81490636
58Hippo signaling pathway_Homo sapiens_hsa043900.81456044
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81114845
60Hedgehog signaling pathway_Homo sapiens_hsa043400.81034146
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80876121
62ABC transporters_Homo sapiens_hsa020100.80663267
63Wnt signaling pathway_Homo sapiens_hsa043100.80419116
64Ovarian steroidogenesis_Homo sapiens_hsa049130.79378687
65Cholinergic synapse_Homo sapiens_hsa047250.78807675
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78391556
67Axon guidance_Homo sapiens_hsa043600.76809772
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76519473
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75627259
70Propanoate metabolism_Homo sapiens_hsa006400.73142939
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71776133
72Basal cell carcinoma_Homo sapiens_hsa052170.71559531
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68903661
74Long-term potentiation_Homo sapiens_hsa047200.68359530
75Starch and sucrose metabolism_Homo sapiens_hsa005000.66738603
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66401659
77Proteoglycans in cancer_Homo sapiens_hsa052050.65752496
78Purine metabolism_Homo sapiens_hsa002300.63124296
79Retinol metabolism_Homo sapiens_hsa008300.62324735
80Glucagon signaling pathway_Homo sapiens_hsa049220.58007291
81Phototransduction_Homo sapiens_hsa047440.55161544
82Dopaminergic synapse_Homo sapiens_hsa047280.54319561
83Tyrosine metabolism_Homo sapiens_hsa003500.53767552
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53305788
85beta-Alanine metabolism_Homo sapiens_hsa004100.52476753
86Arginine biosynthesis_Homo sapiens_hsa002200.51747826
87FoxO signaling pathway_Homo sapiens_hsa040680.49741185
88Huntingtons disease_Homo sapiens_hsa050160.48843874
89Pathways in cancer_Homo sapiens_hsa052000.48038574
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47027053
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46630302
92Butanoate metabolism_Homo sapiens_hsa006500.46351025
93MAPK signaling pathway_Homo sapiens_hsa040100.45140549
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43912957
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43316480
96Rap1 signaling pathway_Homo sapiens_hsa040150.42191473
97PPAR signaling pathway_Homo sapiens_hsa033200.41234637
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38545902
99Alcoholism_Homo sapiens_hsa050340.37240077
100Nicotine addiction_Homo sapiens_hsa050330.35912584

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