

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | myofibril assembly (GO:0030239) | 5.54743756 |
| 2 | muscle cell cellular homeostasis (GO:0046716) | 5.41592827 |
| 3 | response to muscle activity (GO:0014850) | 5.40539762 |
| 4 | relaxation of smooth muscle (GO:0044557) | 5.33542112 |
| 5 | cGMP-mediated signaling (GO:0019934) | 4.94667238 |
| 6 | mesenchymal-epithelial cell signaling (GO:0060638) | 4.94452093 |
| 7 | fibroblast migration (GO:0010761) | 4.77723034 |
| 8 | sarcomere organization (GO:0045214) | 4.76358706 |
| 9 | muscle filament sliding (GO:0030049) | 4.74180095 |
| 10 | actin-myosin filament sliding (GO:0033275) | 4.74180095 |
| 11 | actin-mediated cell contraction (GO:0070252) | 4.72910180 |
| 12 | regulation of relaxation of muscle (GO:1901077) | 4.69987496 |
| 13 | relaxation of muscle (GO:0090075) | 4.30137986 |
| 14 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 4.23767889 |
| 15 | cellular response to zinc ion (GO:0071294) | 4.22504985 |
| 16 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 4.19549481 |
| 17 | regulation of branching involved in salivary gland morphogenesis (GO:0060693) | 4.17355289 |
| 18 | coenzyme catabolic process (GO:0009109) | 4.15290365 |
| 19 | cellular response to interferon-alpha (GO:0035457) | 4.04055743 |
| 20 | ovulation cycle (GO:0042698) | 4.02913946 |
| 21 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 4.02714519 |
| 22 | cardiac myofibril assembly (GO:0055003) | 3.92491468 |
| 23 | muscle fiber development (GO:0048747) | 3.81537307 |
| 24 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 3.74891585 |
| 25 | urinary tract smooth muscle contraction (GO:0014848) | 3.70785112 |
| 26 | regulation of skeletal muscle contraction (GO:0014819) | 3.68250203 |
| 27 | actin filament-based movement (GO:0030048) | 3.62908355 |
| 28 | activation of protein kinase B activity (GO:0032148) | 3.61620371 |
| 29 | regulation of myoblast differentiation (GO:0045661) | 3.61580880 |
| 30 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 3.59153782 |
| 31 | axon extension involved in axon guidance (GO:0048846) | 3.59153782 |
| 32 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.56917583 |
| 33 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 3.48506181 |
| 34 | protein localization to cell surface (GO:0034394) | 3.46870556 |
| 35 | ganglion development (GO:0061548) | 3.43668324 |
| 36 | DNA integration (GO:0015074) | 3.38394137 |
| 37 | dermatan sulfate biosynthetic process (GO:0030208) | 3.37962627 |
| 38 | positive regulation of catecholamine secretion (GO:0033605) | 3.37685695 |
| 39 | regulation of oxidative phosphorylation (GO:0002082) | 3.37603405 |
| 40 | positive regulation of cardiac muscle hypertrophy (GO:0010613) | 3.35159628 |
| 41 | positive regulation of muscle hypertrophy (GO:0014742) | 3.35159628 |
| 42 | aggressive behavior (GO:0002118) | 3.30810849 |
| 43 | potassium ion import (GO:0010107) | 3.30634283 |
| 44 | cardiac muscle hypertrophy (GO:0003300) | 3.29905258 |
| 45 | regulation of oxidative stress-induced neuron death (GO:1903203) | 3.29457213 |
| 46 | regulation of cell communication by electrical coupling (GO:0010649) | 3.26601294 |
| 47 | actomyosin structure organization (GO:0031032) | 3.26163817 |
| 48 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.20994171 |
| 49 | paraxial mesoderm development (GO:0048339) | 3.20978768 |
| 50 | response to inactivity (GO:0014854) | 3.19221249 |
| 51 | muscle contraction (GO:0006936) | 3.17797189 |
| 52 | adult heart development (GO:0007512) | 3.16655241 |
| 53 | striated muscle hypertrophy (GO:0014897) | 3.16386017 |
| 54 | glucocorticoid biosynthetic process (GO:0006704) | 3.13314875 |
| 55 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 3.08667473 |
| 56 | relaxation of cardiac muscle (GO:0055119) | 3.08032353 |
| 57 | muscle system process (GO:0003012) | 3.07304467 |
| 58 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 3.06746520 |
| 59 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.06353721 |
| 60 | cellular response to cadmium ion (GO:0071276) | 3.02081694 |
| 61 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800) | 3.00350585 |
| 62 | cGMP metabolic process (GO:0046068) | 3.00302861 |
| 63 | plasma membrane repair (GO:0001778) | 2.99841356 |
| 64 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 2.99354960 |
| 65 | arginine catabolic process (GO:0006527) | 2.97701671 |
| 66 | regulation of cardiac muscle hypertrophy (GO:0010611) | 2.96597227 |
| 67 | lymphangiogenesis (GO:0001946) | 2.94829149 |
| 68 | negative regulation of muscle contraction (GO:0045932) | 2.94709982 |
| 69 | negative regulation of striated muscle cell apoptotic process (GO:0010664) | 2.93597132 |
| 70 | regulation of skeletal muscle fiber development (GO:0048742) | 2.92538828 |
| 71 | dermatan sulfate metabolic process (GO:0030205) | 2.91866554 |
| 72 | lateral sprouting from an epithelium (GO:0060601) | 2.90762481 |
| 73 | smooth muscle tissue development (GO:0048745) | 2.90483021 |
| 74 | regulation of muscle hypertrophy (GO:0014743) | 2.87847816 |
| 75 | regulation of phosphoprotein phosphatase activity (GO:0043666) | 2.85117383 |
| 76 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 2.84731394 |
| 77 | musculoskeletal movement (GO:0050881) | 2.84649674 |
| 78 | multicellular organismal movement (GO:0050879) | 2.84649674 |
| 79 | muscle cell fate commitment (GO:0042693) | 2.83164593 |
| 80 | motile cilium assembly (GO:0044458) | 2.77422363 |
| 81 | cGMP biosynthetic process (GO:0006182) | 2.73124198 |
| 82 | muscle hypertrophy (GO:0014896) | 2.72562200 |
| 83 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 2.72161253 |
| 84 | positive regulation of release of sequestered calcium ion into cytosol (GO:0051281) | 2.67113968 |
| 85 | regulation of muscle adaptation (GO:0043502) | 2.66645001 |
| 86 | ADP metabolic process (GO:0046031) | 2.66186085 |
| 87 | regulation of phospholipase A2 activity (GO:0032429) | 2.65902337 |
| 88 | negative regulation of homotypic cell-cell adhesion (GO:0034111) | 2.65038841 |
| 89 | AMP metabolic process (GO:0046033) | 2.62110135 |
| 90 | myotube cell development (GO:0014904) | 2.61254617 |
| 91 | smooth muscle cell differentiation (GO:0051145) | 2.60998067 |
| 92 | positive regulation of myoblast differentiation (GO:0045663) | 2.59921277 |
| 93 | otic vesicle formation (GO:0030916) | 2.59298615 |
| 94 | skeletal muscle tissue development (GO:0007519) | 2.56991267 |
| 95 | striated muscle cell development (GO:0055002) | 2.55566995 |
| 96 | kidney morphogenesis (GO:0060993) | 2.53874591 |
| 97 | regulation of keratinocyte proliferation (GO:0010837) | 2.52320491 |
| 98 | smooth muscle contraction (GO:0006939) | 2.51289472 |
| 99 | regulation of transforming growth factor beta2 production (GO:0032909) | 2.51175140 |
| 100 | cofactor catabolic process (GO:0051187) | 2.48545095 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 4.60167318 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.43889266 |
| 3 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.95922151 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.89650737 |
| 5 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.78673092 |
| 6 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.43479817 |
| 7 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.43269822 |
| 8 | VDR_22108803_ChIP-Seq_LS180_Human | 2.42199451 |
| 9 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.40593469 |
| 10 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.34654496 |
| 11 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 2.26887782 |
| 12 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 2.21106557 |
| 13 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.14235939 |
| 14 | FUS_26573619_Chip-Seq_HEK293_Human | 2.11225174 |
| 15 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.07425764 |
| 16 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.01469347 |
| 17 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.99406637 |
| 18 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.96511343 |
| 19 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.96129750 |
| 20 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.90962707 |
| 21 | P300_19829295_ChIP-Seq_ESCs_Human | 1.90643683 |
| 22 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.86926385 |
| 23 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.86288263 |
| 24 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.84430542 |
| 25 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.82190462 |
| 26 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.77470656 |
| 27 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.77352227 |
| 28 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.76306484 |
| 29 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.69341841 |
| 30 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.68796731 |
| 31 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.65929723 |
| 32 | TP53_16413492_ChIP-PET_HCT116_Human | 1.65737539 |
| 33 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.64698702 |
| 34 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.64620858 |
| 35 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.64270502 |
| 36 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.64270502 |
| 37 | EWS_26573619_Chip-Seq_HEK293_Human | 1.63794626 |
| 38 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.62501810 |
| 39 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.58607309 |
| 40 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.57468690 |
| 41 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.54990882 |
| 42 | CJUN_26792858_Chip-Seq_BT549_Human | 1.54245974 |
| 43 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.53870281 |
| 44 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.53781141 |
| 45 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.53059522 |
| 46 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.50929687 |
| 47 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.50587795 |
| 48 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.46865832 |
| 49 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.46117920 |
| 50 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.41634622 |
| 51 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.41409800 |
| 52 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.41003727 |
| 53 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.38691480 |
| 54 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.38444400 |
| 55 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.38280413 |
| 56 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.37454824 |
| 57 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.36403310 |
| 58 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.34648222 |
| 59 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.34648222 |
| 60 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.34173783 |
| 61 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.33256551 |
| 62 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.33256551 |
| 63 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.31583321 |
| 64 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.31436040 |
| 65 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.31429860 |
| 66 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.30909016 |
| 67 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.28411979 |
| 68 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.28411979 |
| 69 | AR_25329375_ChIP-Seq_VCAP_Human | 1.28049350 |
| 70 | STAT3_23295773_ChIP-Seq_U87_Human | 1.27689083 |
| 71 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.25948101 |
| 72 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.24560053 |
| 73 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.24322497 |
| 74 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.22924984 |
| 75 | TCF4_23295773_ChIP-Seq_U87_Human | 1.22000602 |
| 76 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.21005697 |
| 77 | RXR_22108803_ChIP-Seq_LS180_Human | 1.18767579 |
| 78 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.15910316 |
| 79 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.15569336 |
| 80 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.15462493 |
| 81 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.13217834 |
| 82 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11667904 |
| 83 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.11526598 |
| 84 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.10165670 |
| 85 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.09669910 |
| 86 | TBL1_22424771_ChIP-Seq_293T_Human | 1.09057422 |
| 87 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.08951506 |
| 88 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.08750543 |
| 89 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.08723581 |
| 90 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.08399925 |
| 91 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.08307847 |
| 92 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.06722951 |
| 93 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.05482720 |
| 94 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.04434000 |
| 95 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.04153488 |
| 96 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.02676441 |
| 97 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.02286410 |
| 98 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.02206764 |
| 99 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.02023275 |
| 100 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 1.01718202 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000749_muscle_degeneration | 5.00359872 |
| 2 | MP0004084_abnormal_cardiac_muscle | 4.08910570 |
| 3 | MP0002837_dystrophic_cardiac_calcinosis | 3.81992586 |
| 4 | MP0004036_abnormal_muscle_relaxation | 3.63562119 |
| 5 | MP0004215_abnormal_myocardial_fiber | 2.96781742 |
| 6 | MP0004145_abnormal_muscle_electrophysio | 2.90144958 |
| 7 | MP0005620_abnormal_muscle_contractility | 2.47625040 |
| 8 | MP0002108_abnormal_muscle_morphology | 2.46152611 |
| 9 | MP0004272_abnormal_basement_membrane | 2.37083883 |
| 10 | MP0010368_abnormal_lymphatic_system | 2.23802986 |
| 11 | MP0001299_abnormal_eye_distance/ | 2.22438489 |
| 12 | MP0003806_abnormal_nucleotide_metabolis | 2.20937394 |
| 13 | MP0009697_abnormal_copulation | 2.16279087 |
| 14 | MP0005187_abnormal_penis_morphology | 2.12401875 |
| 15 | MP0003136_yellow_coat_color | 2.11278179 |
| 16 | MP0008004_abnormal_stomach_pH | 2.05588629 |
| 17 | MP0008438_abnormal_cutaneous_collagen | 2.05228274 |
| 18 | MP0000751_myopathy | 2.00098840 |
| 19 | MP0005503_abnormal_tendon_morphology | 1.92596426 |
| 20 | MP0005330_cardiomyopathy | 1.88373962 |
| 21 | MP0005275_abnormal_skin_tensile | 1.88110597 |
| 22 | MP0002269_muscular_atrophy | 1.87288727 |
| 23 | MP0002638_abnormal_pupillary_reflex | 1.86321000 |
| 24 | MP0003950_abnormal_plasma_membrane | 1.84097669 |
| 25 | MP0001485_abnormal_pinna_reflex | 1.77501327 |
| 26 | MP0003646_muscle_fatigue | 1.77170240 |
| 27 | MP0002127_abnormal_cardiovascular_syste | 1.74944016 |
| 28 | MP0010386_abnormal_urinary_bladder | 1.70113704 |
| 29 | MP0002102_abnormal_ear_morphology | 1.65936092 |
| 30 | MP0004087_abnormal_muscle_fiber | 1.64251594 |
| 31 | MP0005623_abnormal_meninges_morphology | 1.64119904 |
| 32 | MP0003941_abnormal_skin_development | 1.62021157 |
| 33 | MP0005595_abnormal_vascular_smooth | 1.57451474 |
| 34 | MP0001661_extended_life_span | 1.55042948 |
| 35 | MP0005369_muscle_phenotype | 1.52992876 |
| 36 | MP0001984_abnormal_olfaction | 1.52048199 |
| 37 | MP0006072_abnormal_retinal_apoptosis | 1.49992500 |
| 38 | MP0005248_abnormal_Harderian_gland | 1.46833546 |
| 39 | MP0008775_abnormal_heart_ventricle | 1.46582284 |
| 40 | MP0003385_abnormal_body_wall | 1.45874962 |
| 41 | MP0009780_abnormal_chondrocyte_physiolo | 1.44277053 |
| 42 | MP0000759_abnormal_skeletal_muscle | 1.40895260 |
| 43 | MP0003879_abnormal_hair_cell | 1.40740297 |
| 44 | MP0000767_abnormal_smooth_muscle | 1.37796716 |
| 45 | MP0000013_abnormal_adipose_tissue | 1.37404452 |
| 46 | MP0004270_analgesia | 1.37189134 |
| 47 | MP0000534_abnormal_ureter_morphology | 1.37156397 |
| 48 | MP0009250_abnormal_appendicular_skeleto | 1.34383909 |
| 49 | MP0000566_synostosis | 1.33970070 |
| 50 | MP0001188_hyperpigmentation | 1.32226375 |
| 51 | MP0002106_abnormal_muscle_physiology | 1.32114255 |
| 52 | MP0004085_abnormal_heartbeat | 1.31146373 |
| 53 | MP0004510_myositis | 1.30918109 |
| 54 | MP0001879_abnormal_lymphatic_vessel | 1.30096750 |
| 55 | MP0000747_muscle_weakness | 1.25427162 |
| 56 | MP0005385_cardiovascular_system_phenoty | 1.24913264 |
| 57 | MP0001544_abnormal_cardiovascular_syste | 1.24913264 |
| 58 | MP0000750_abnormal_muscle_regeneration | 1.22133294 |
| 59 | MP0005646_abnormal_pituitary_gland | 1.20818862 |
| 60 | MP0004484_altered_response_of | 1.19459108 |
| 61 | MP0002972_abnormal_cardiac_muscle | 1.18779843 |
| 62 | MP0002160_abnormal_reproductive_system | 1.11539055 |
| 63 | MP0002822_catalepsy | 1.06171108 |
| 64 | MP0010030_abnormal_orbit_morphology | 1.05515610 |
| 65 | MP0003942_abnormal_urinary_system | 1.02546451 |
| 66 | MP0000230_abnormal_systemic_arterial | 1.01539234 |
| 67 | MP0006138_congestive_heart_failure | 0.96092943 |
| 68 | MP0003315_abnormal_perineum_morphology | 0.95096601 |
| 69 | MP0002751_abnormal_autonomic_nervous | 0.95035368 |
| 70 | MP0000049_abnormal_middle_ear | 0.90995072 |
| 71 | MP0005171_absent_coat_pigmentation | 0.90878764 |
| 72 | MP0008789_abnormal_olfactory_epithelium | 0.90407128 |
| 73 | MP0002233_abnormal_nose_morphology | 0.88932559 |
| 74 | MP0005253_abnormal_eye_physiology | 0.87889631 |
| 75 | MP0000762_abnormal_tongue_morphology | 0.86074287 |
| 76 | MP0001440_abnormal_grooming_behavior | 0.85749477 |
| 77 | MP0002272_abnormal_nervous_system | 0.85293202 |
| 78 | MP0002132_abnormal_respiratory_system | 0.84608419 |
| 79 | MP0000733_abnormal_muscle_development | 0.84142015 |
| 80 | MP0002295_abnormal_pulmonary_circulatio | 0.83658437 |
| 81 | MP0001664_abnormal_digestion | 0.82768910 |
| 82 | MP0010630_abnormal_cardiac_muscle | 0.82049822 |
| 83 | MP0005508_abnormal_skeleton_morphology | 0.80804048 |
| 84 | MP0004742_abnormal_vestibular_system | 0.80796647 |
| 85 | MP0000026_abnormal_inner_ear | 0.79904746 |
| 86 | MP0002128_abnormal_blood_circulation | 0.78902229 |
| 87 | MP0004134_abnormal_chest_morphology | 0.78707463 |
| 88 | MP0000631_abnormal_neuroendocrine_gland | 0.78227860 |
| 89 | MP0001486_abnormal_startle_reflex | 0.77969374 |
| 90 | MP0009046_muscle_twitch | 0.77558298 |
| 91 | MP0003868_abnormal_feces_composition | 0.74747837 |
| 92 | MP0003890_abnormal_embryonic-extraembry | 0.73053880 |
| 93 | MP0001177_atelectasis | 0.72673190 |
| 94 | MP0000538_abnormal_urinary_bladder | 0.72134341 |
| 95 | MP0003755_abnormal_palate_morphology | 0.71231698 |
| 96 | MP0005499_abnormal_olfactory_system | 0.69058341 |
| 97 | MP0005394_taste/olfaction_phenotype | 0.69058341 |
| 98 | MP0002090_abnormal_vision | 0.68828655 |
| 99 | MP0006054_spinal_hemorrhage | 0.66293600 |
| 100 | MP0003137_abnormal_impulse_conducting | 0.63505289 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 6.87396218 |
| 2 | Muscle fiber inclusion bodies (HP:0100299) | 6.55496822 |
| 3 | Nemaline bodies (HP:0003798) | 6.22702642 |
| 4 | Hyporeflexia of lower limbs (HP:0002600) | 5.93272685 |
| 5 | Aortic aneurysm (HP:0004942) | 4.84541184 |
| 6 | Abnormality of the calf musculature (HP:0001430) | 4.74722776 |
| 7 | Type 1 muscle fiber predominance (HP:0003803) | 4.36047335 |
| 8 | Calf muscle hypertrophy (HP:0008981) | 4.35535412 |
| 9 | Sensory axonal neuropathy (HP:0003390) | 4.31780834 |
| 10 | Rimmed vacuoles (HP:0003805) | 4.30716851 |
| 11 | Exercise-induced myalgia (HP:0003738) | 4.23720539 |
| 12 | Exercise-induced muscle cramps (HP:0003710) | 4.12526540 |
| 13 | Muscle hypertrophy of the lower extremities (HP:0008968) | 4.11835308 |
| 14 | EMG: myopathic abnormalities (HP:0003458) | 3.99435835 |
| 15 | Neck muscle weakness (HP:0000467) | 3.62133454 |
| 16 | Scapular winging (HP:0003691) | 3.55455847 |
| 17 | Clumsiness (HP:0002312) | 3.42067653 |
| 18 | Proximal amyotrophy (HP:0007126) | 3.29279641 |
| 19 | Abnormality of the shoulder girdle musculature (HP:0001435) | 3.26682561 |
| 20 | Muscle fiber splitting (HP:0003555) | 3.24618918 |
| 21 | Distal arthrogryposis (HP:0005684) | 3.22735706 |
| 22 | Sudden death (HP:0001699) | 3.10995640 |
| 23 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.94540015 |
| 24 | Muscular dystrophy (HP:0003560) | 2.94529845 |
| 25 | Popliteal pterygium (HP:0009756) | 2.91809240 |
| 26 | Spinal rigidity (HP:0003306) | 2.91752735 |
| 27 | Increased variability in muscle fiber diameter (HP:0003557) | 2.88954904 |
| 28 | Steppage gait (HP:0003376) | 2.78613849 |
| 29 | Dysmetric saccades (HP:0000641) | 2.76520296 |
| 30 | Frequent falls (HP:0002359) | 2.74907335 |
| 31 | Axonal loss (HP:0003447) | 2.69484060 |
| 32 | Difficulty running (HP:0009046) | 2.56495238 |
| 33 | Myoglobinuria (HP:0002913) | 2.50388724 |
| 34 | Atonic seizures (HP:0010819) | 2.46593967 |
| 35 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.45253969 |
| 36 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.37759990 |
| 37 | Short tibia (HP:0005736) | 2.35156930 |
| 38 | Areflexia of lower limbs (HP:0002522) | 2.34194138 |
| 39 | Malignant hyperthermia (HP:0002047) | 2.33552090 |
| 40 | Right ventricular cardiomyopathy (HP:0011663) | 2.30492489 |
| 41 | Hypoventilation (HP:0002791) | 2.24270657 |
| 42 | Dilated cardiomyopathy (HP:0001644) | 2.23715666 |
| 43 | Lipoatrophy (HP:0100578) | 2.23682294 |
| 44 | Aortic dissection (HP:0002647) | 2.23290889 |
| 45 | Resting tremor (HP:0002322) | 2.22713161 |
| 46 | Septo-optic dysplasia (HP:0100842) | 2.22046296 |
| 47 | Reduced antithrombin III activity (HP:0001976) | 2.20107449 |
| 48 | Bulbar palsy (HP:0001283) | 2.18559230 |
| 49 | Abnormality of the columella (HP:0009929) | 2.15881349 |
| 50 | Myopathic facies (HP:0002058) | 2.13167438 |
| 51 | Short hallux (HP:0010109) | 2.09092185 |
| 52 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 2.08923171 |
| 53 | Facial diplegia (HP:0001349) | 2.05952060 |
| 54 | Spinal cord lesions (HP:0100561) | 2.02923934 |
| 55 | Syringomyelia (HP:0003396) | 2.02923934 |
| 56 | Limited hip movement (HP:0008800) | 2.02871608 |
| 57 | Broad metatarsal (HP:0001783) | 2.00000473 |
| 58 | Preaxial foot polydactyly (HP:0001841) | 1.98238458 |
| 59 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.97614046 |
| 60 | Broad-based gait (HP:0002136) | 1.97352056 |
| 61 | Knee flexion contracture (HP:0006380) | 1.96679416 |
| 62 | Malnutrition (HP:0004395) | 1.96166394 |
| 63 | Gaze-evoked nystagmus (HP:0000640) | 1.94989912 |
| 64 | Abnormality of the frontal sinuses (HP:0002687) | 1.94400566 |
| 65 | Abnormality of incisor morphology (HP:0011063) | 1.93596286 |
| 66 | Aplasia/Hypoplasia of the hallux (HP:0008362) | 1.92469619 |
| 67 | Foot dorsiflexor weakness (HP:0009027) | 1.91413260 |
| 68 | Rhabdomyolysis (HP:0003201) | 1.88967042 |
| 69 | Abnormality of the foot musculature (HP:0001436) | 1.88577603 |
| 70 | Aplasia/Hypoplasia involving the sinuses (HP:0009120) | 1.87431148 |
| 71 | Osteolytic defects of the hand bones (HP:0009699) | 1.87239623 |
| 72 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.87239623 |
| 73 | Abnormality of the ischium (HP:0003174) | 1.86502567 |
| 74 | Prolonged QT interval (HP:0001657) | 1.84739430 |
| 75 | Scanning speech (HP:0002168) | 1.83793039 |
| 76 | Ectopia lentis (HP:0001083) | 1.82465276 |
| 77 | Hypothermia (HP:0002045) | 1.81113595 |
| 78 | Broad ribs (HP:0000885) | 1.81093206 |
| 79 | Ventricular fibrillation (HP:0001663) | 1.79656977 |
| 80 | Optic nerve hypoplasia (HP:0000609) | 1.79628050 |
| 81 | Abnormality of the incisor (HP:0000676) | 1.78141274 |
| 82 | Atrial fibrillation (HP:0005110) | 1.77736235 |
| 83 | Action tremor (HP:0002345) | 1.77446936 |
| 84 | Postural instability (HP:0002172) | 1.77096657 |
| 85 | Median cleft lip (HP:0000161) | 1.75733181 |
| 86 | Eosinophilia (HP:0001880) | 1.72737838 |
| 87 | Bifid tongue (HP:0010297) | 1.69490534 |
| 88 | Generalized muscle weakness (HP:0003324) | 1.67935430 |
| 89 | Myotonia (HP:0002486) | 1.63213727 |
| 90 | Central scotoma (HP:0000603) | 1.61826524 |
| 91 | Long clavicles (HP:0000890) | 1.58712540 |
| 92 | Depressed nasal tip (HP:0000437) | 1.58276592 |
| 93 | Overgrowth (HP:0001548) | 1.56700322 |
| 94 | Rhinitis (HP:0012384) | 1.56632644 |
| 95 | Febrile seizures (HP:0002373) | 1.53695457 |
| 96 | Weak cry (HP:0001612) | 1.53097353 |
| 97 | Progressive cerebellar ataxia (HP:0002073) | 1.53057123 |
| 98 | Syncope (HP:0001279) | 1.52767184 |
| 99 | Midline defect of the nose (HP:0004122) | 1.51772476 |
| 100 | Truncal ataxia (HP:0002078) | 1.51369051 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | OBSCN | 6.77911822 |
| 2 | PINK1 | 6.07665592 |
| 3 | TNIK | 4.36301298 |
| 4 | LATS1 | 3.05316704 |
| 5 | MYLK | 3.00266697 |
| 6 | STK38L | 2.83142254 |
| 7 | AKT3 | 2.65372196 |
| 8 | PNCK | 2.26070930 |
| 9 | FRK | 2.19706415 |
| 10 | PHKG2 | 2.12034994 |
| 11 | PHKG1 | 2.12034994 |
| 12 | MAP3K10 | 2.11990902 |
| 13 | MARK3 | 2.09488897 |
| 14 | IRAK2 | 1.83526960 |
| 15 | DDR2 | 1.72515817 |
| 16 | PAK3 | 1.69661969 |
| 17 | BMPR1B | 1.67019392 |
| 18 | DMPK | 1.48198008 |
| 19 | MELK | 1.47682689 |
| 20 | WNK3 | 1.41576218 |
| 21 | TGFBR1 | 1.25656320 |
| 22 | PAK2 | 1.24467826 |
| 23 | NLK | 1.20509414 |
| 24 | MAPK12 | 1.19777839 |
| 25 | SGK2 | 1.14843875 |
| 26 | MAP2K7 | 1.14170466 |
| 27 | TIE1 | 1.10425817 |
| 28 | GRK5 | 1.09938184 |
| 29 | SGK494 | 1.07566656 |
| 30 | SGK223 | 1.07566656 |
| 31 | MAPK13 | 1.06464879 |
| 32 | LATS2 | 1.03389535 |
| 33 | MUSK | 1.02868354 |
| 34 | ROCK1 | 0.99884762 |
| 35 | PRKG2 | 0.98329534 |
| 36 | NEK2 | 0.92058953 |
| 37 | STK3 | 0.89442930 |
| 38 | LIMK1 | 0.88977722 |
| 39 | CDK8 | 0.82799941 |
| 40 | RPS6KB1 | 0.82717936 |
| 41 | PKN1 | 0.77917450 |
| 42 | TTN | 0.77542704 |
| 43 | PRKG1 | 0.76799619 |
| 44 | NUAK1 | 0.76777780 |
| 45 | STK39 | 0.73919266 |
| 46 | TLK1 | 0.70348819 |
| 47 | CCNB1 | 0.67219600 |
| 48 | STK38 | 0.65371785 |
| 49 | CSNK1A1L | 0.64686373 |
| 50 | PDGFRB | 0.63431762 |
| 51 | EIF2AK3 | 0.61363186 |
| 52 | STK24 | 0.60535478 |
| 53 | PBK | 0.59922102 |
| 54 | MAPKAPK3 | 0.58072517 |
| 55 | ILK | 0.56818942 |
| 56 | OXSR1 | 0.55729293 |
| 57 | PTK2B | 0.53064770 |
| 58 | MARK1 | 0.51098150 |
| 59 | MAP3K7 | 0.50634907 |
| 60 | SGK3 | 0.50534494 |
| 61 | CSNK1G1 | 0.49811200 |
| 62 | ACVR1B | 0.49699510 |
| 63 | CAMK2D | 0.47489946 |
| 64 | MAPK15 | 0.47397949 |
| 65 | STK16 | 0.44896034 |
| 66 | PIK3CA | 0.43020899 |
| 67 | PDGFRA | 0.42465333 |
| 68 | MINK1 | 0.42050471 |
| 69 | PIK3CG | 0.40456729 |
| 70 | PRKCQ | 0.38626297 |
| 71 | WEE1 | 0.37905614 |
| 72 | DAPK3 | 0.37617734 |
| 73 | VRK1 | 0.37569212 |
| 74 | PRKACB | 0.37254438 |
| 75 | CASK | 0.37101831 |
| 76 | ADRBK1 | 0.36935325 |
| 77 | PRKAA1 | 0.36425814 |
| 78 | CSNK1G2 | 0.36096647 |
| 79 | ZAK | 0.35538937 |
| 80 | FGFR2 | 0.35429694 |
| 81 | GRK1 | 0.35043855 |
| 82 | ABL2 | 0.34862947 |
| 83 | ROCK2 | 0.34498041 |
| 84 | NTRK2 | 0.33870795 |
| 85 | MAP3K4 | 0.32433281 |
| 86 | CDK3 | 0.31562676 |
| 87 | PRKACA | 0.30528885 |
| 88 | RAF1 | 0.29675614 |
| 89 | CLK1 | 0.28899044 |
| 90 | CAMK2G | 0.28622413 |
| 91 | AKT2 | 0.28480233 |
| 92 | MKNK2 | 0.27433671 |
| 93 | CSNK1G3 | 0.26749118 |
| 94 | PRKCE | 0.26466294 |
| 95 | TGFBR2 | 0.26121682 |
| 96 | PRKD3 | 0.23808401 |
| 97 | RET | 0.23799390 |
| 98 | GSK3A | 0.23579493 |
| 99 | BRD4 | 0.23458459 |
| 100 | CDK5 | 0.23381769 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.13031257 |
| 2 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 2.97052434 |
| 3 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 2.71625783 |
| 4 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.70554819 |
| 5 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.52227653 |
| 6 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 2.29195133 |
| 7 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.27145439 |
| 8 | Olfactory transduction_Homo sapiens_hsa04740 | 2.18549439 |
| 9 | Sulfur relay system_Homo sapiens_hsa04122 | 2.08099885 |
| 10 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.06220409 |
| 11 | ECM-receptor interaction_Homo sapiens_hsa04512 | 2.03583581 |
| 12 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.94089930 |
| 13 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.89887843 |
| 14 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.85290045 |
| 15 | Circadian rhythm_Homo sapiens_hsa04710 | 1.81388312 |
| 16 | Circadian entrainment_Homo sapiens_hsa04713 | 1.78731827 |
| 17 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.64479699 |
| 18 | Renin secretion_Homo sapiens_hsa04924 | 1.64336982 |
| 19 | Salivary secretion_Homo sapiens_hsa04970 | 1.63503709 |
| 20 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.62576740 |
| 21 | Focal adhesion_Homo sapiens_hsa04510 | 1.60373896 |
| 22 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.59852007 |
| 23 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.57025865 |
| 24 | Gap junction_Homo sapiens_hsa04540 | 1.55299949 |
| 25 | GABAergic synapse_Homo sapiens_hsa04727 | 1.54575796 |
| 26 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.54559193 |
| 27 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.44451917 |
| 28 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.43783836 |
| 29 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.37345322 |
| 30 | Mineral absorption_Homo sapiens_hsa04978 | 1.37342167 |
| 31 | Taste transduction_Homo sapiens_hsa04742 | 1.37126238 |
| 32 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.35407245 |
| 33 | Melanoma_Homo sapiens_hsa05218 | 1.28933750 |
| 34 | Parkinsons disease_Homo sapiens_hsa05012 | 1.27681788 |
| 35 | Long-term depression_Homo sapiens_hsa04730 | 1.25624937 |
| 36 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.14278284 |
| 37 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.12277001 |
| 38 | Alzheimers disease_Homo sapiens_hsa05010 | 1.11813617 |
| 39 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.11634103 |
| 40 | Pancreatic secretion_Homo sapiens_hsa04972 | 1.06964910 |
| 41 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.02643680 |
| 42 | Platelet activation_Homo sapiens_hsa04611 | 0.97815225 |
| 43 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.96902278 |
| 44 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.96882242 |
| 45 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.96128436 |
| 46 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.95770401 |
| 47 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.93829953 |
| 48 | Morphine addiction_Homo sapiens_hsa05032 | 0.89957484 |
| 49 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.89589702 |
| 50 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.88598131 |
| 51 | Insulin secretion_Homo sapiens_hsa04911 | 0.87068400 |
| 52 | Tight junction_Homo sapiens_hsa04530 | 0.86666533 |
| 53 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.86191268 |
| 54 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.84094893 |
| 55 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.83944629 |
| 56 | Melanogenesis_Homo sapiens_hsa04916 | 0.83307735 |
| 57 | Adherens junction_Homo sapiens_hsa04520 | 0.81490636 |
| 58 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.81456044 |
| 59 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.81114845 |
| 60 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.81034146 |
| 61 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.80876121 |
| 62 | ABC transporters_Homo sapiens_hsa02010 | 0.80663267 |
| 63 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.80419116 |
| 64 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.79378687 |
| 65 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.78807675 |
| 66 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.78391556 |
| 67 | Axon guidance_Homo sapiens_hsa04360 | 0.76809772 |
| 68 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.76519473 |
| 69 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.75627259 |
| 70 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.73142939 |
| 71 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.71776133 |
| 72 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.71559531 |
| 73 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.68903661 |
| 74 | Long-term potentiation_Homo sapiens_hsa04720 | 0.68359530 |
| 75 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.66738603 |
| 76 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.66401659 |
| 77 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.65752496 |
| 78 | Purine metabolism_Homo sapiens_hsa00230 | 0.63124296 |
| 79 | Retinol metabolism_Homo sapiens_hsa00830 | 0.62324735 |
| 80 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.58007291 |
| 81 | Phototransduction_Homo sapiens_hsa04744 | 0.55161544 |
| 82 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.54319561 |
| 83 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.53767552 |
| 84 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.53305788 |
| 85 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.52476753 |
| 86 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.51747826 |
| 87 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.49741185 |
| 88 | Huntingtons disease_Homo sapiens_hsa05016 | 0.48843874 |
| 89 | Pathways in cancer_Homo sapiens_hsa05200 | 0.48038574 |
| 90 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.47027053 |
| 91 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.46630302 |
| 92 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.46351025 |
| 93 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.45140549 |
| 94 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.43912957 |
| 95 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.43316480 |
| 96 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.42191473 |
| 97 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.41234637 |
| 98 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.38545902 |
| 99 | Alcoholism_Homo sapiens_hsa05034 | 0.37240077 |
| 100 | Nicotine addiction_Homo sapiens_hsa05033 | 0.35912584 |

