RTCA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.48510478
2DNA strand elongation involved in DNA replication (GO:0006271)4.47360784
3DNA deamination (GO:0045006)4.45112457
4formation of translation preinitiation complex (GO:0001731)4.28637236
5DNA strand elongation (GO:0022616)4.28491027
6organelle disassembly (GO:1903008)4.21754837
7protein neddylation (GO:0045116)4.18507683
8DNA replication initiation (GO:0006270)4.16244280
9ribonucleoprotein complex disassembly (GO:0032988)4.08440045
10positive regulation of mitochondrial fission (GO:0090141)4.01255953
11establishment of integrated proviral latency (GO:0075713)3.94476107
12cullin deneddylation (GO:0010388)3.81939723
13peptidyl-histidine modification (GO:0018202)3.81411193
14telomere maintenance via semi-conservative replication (GO:0032201)3.79001444
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.71924344
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.71872702
17protein deneddylation (GO:0000338)3.69918713
18spliceosomal snRNP assembly (GO:0000387)3.69183050
19peptidyl-arginine omega-N-methylation (GO:0035247)3.59292571
20anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.56641394
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.53887704
22DNA replication checkpoint (GO:0000076)3.52736572
23regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51989036
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50951080
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49998425
26histone arginine methylation (GO:0034969)3.49201856
27deoxyribonucleotide biosynthetic process (GO:0009263)3.48549174
28maturation of SSU-rRNA (GO:0030490)3.47547542
292-deoxyribonucleotide biosynthetic process (GO:0009265)3.45864851
30deoxyribose phosphate biosynthetic process (GO:0046385)3.45864851
31DNA replication-dependent nucleosome organization (GO:0034723)3.43316345
32DNA replication-dependent nucleosome assembly (GO:0006335)3.43316345
33negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.42584761
34negative regulation of ligase activity (GO:0051352)3.42584761
35ribosomal small subunit assembly (GO:0000028)3.41877102
36L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.41362037
37regulation of mitochondrial translation (GO:0070129)3.37295203
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36893900
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36893900
40de novo protein folding (GO:0006458)3.36356602
41chaperone-mediated protein transport (GO:0072321)3.32358512
42nucleobase-containing small molecule interconversion (GO:0015949)3.32111228
43chromatin remodeling at centromere (GO:0031055)3.30686928
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29710194
45proteasome assembly (GO:0043248)3.29634739
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29582125
47CENP-A containing nucleosome assembly (GO:0034080)3.29047933
48telomere maintenance via recombination (GO:0000722)3.27304366
49de novo posttranslational protein folding (GO:0051084)3.27236252
50NADH dehydrogenase complex assembly (GO:0010257)3.27102829
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27102829
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.27102829
53synapsis (GO:0007129)3.27064590
54protein complex biogenesis (GO:0070271)3.27009608
55nucleobase biosynthetic process (GO:0046112)3.26084605
56ribosomal large subunit biogenesis (GO:0042273)3.21212032
57translational elongation (GO:0006414)3.20279946
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19717940
59purine nucleobase biosynthetic process (GO:0009113)3.19628106
60mitochondrial respiratory chain complex assembly (GO:0033108)3.19359565
61histone H2A acetylation (GO:0043968)3.18924093
62translational termination (GO:0006415)3.17339359
63platelet dense granule organization (GO:0060155)3.17192587
64viral transcription (GO:0019083)3.17073972
65negative regulation of microtubule polymerization (GO:0031115)3.16397323
66translational initiation (GO:0006413)3.15783744
67somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.14046098
68isotype switching (GO:0045190)3.14046098
69somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.14046098
70establishment of protein localization to mitochondrial membrane (GO:0090151)3.14017625
71water-soluble vitamin biosynthetic process (GO:0042364)3.10648155
72viral mRNA export from host cell nucleus (GO:0046784)3.09880340
73peptidyl-arginine methylation (GO:0018216)3.08927495
74peptidyl-arginine N-methylation (GO:0035246)3.08927495
75ribosome biogenesis (GO:0042254)3.08914881
76mitotic recombination (GO:0006312)3.08804076
77DNA replication-independent nucleosome assembly (GO:0006336)3.08740177
78DNA replication-independent nucleosome organization (GO:0034724)3.08740177
79telomere maintenance via telomere lengthening (GO:0010833)3.08632147
80mitotic metaphase plate congression (GO:0007080)3.07631400
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07069324
82kinetochore organization (GO:0051383)3.06101912
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06035390
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06035390
85regulation of translational termination (GO:0006449)3.05674943
86rRNA modification (GO:0000154)3.04988851
87kinetochore assembly (GO:0051382)3.04283620
88amino acid activation (GO:0043038)3.03821401
89tRNA aminoacylation (GO:0043039)3.03821401
90positive regulation of ligase activity (GO:0051351)3.03307225
91ATP synthesis coupled proton transport (GO:0015986)3.03291752
92energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03291752
93DNA double-strand break processing (GO:0000729)3.03069618
94protein localization to kinetochore (GO:0034501)3.02461209
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.01975945
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.01975945
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.01975945
98maturation of 5.8S rRNA (GO:0000460)3.01210748
99spliceosomal complex assembly (GO:0000245)3.00743078
100regulation of cellular amino acid metabolic process (GO:0006521)3.00016346
101guanosine-containing compound biosynthetic process (GO:1901070)2.99931883
102nucleotide-excision repair, DNA gap filling (GO:0006297)2.99268177
103pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98991610
104pseudouridine synthesis (GO:0001522)2.98408916
105tRNA aminoacylation for protein translation (GO:0006418)2.98054854
106ribonucleoprotein complex biogenesis (GO:0022613)2.98001491
107histone exchange (GO:0043486)2.97686474
108ribosome assembly (GO:0042255)2.96205950
109signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95680675
110signal transduction involved in DNA damage checkpoint (GO:0072422)2.95680675
111G1/S transition of mitotic cell cycle (GO:0000082)2.95562591
112cell cycle G1/S phase transition (GO:0044843)2.95562591
113rRNA methylation (GO:0031167)2.94368418
114signal transduction involved in cell cycle checkpoint (GO:0072395)2.93585895
115mitotic nuclear envelope disassembly (GO:0007077)2.93399342
116regulation of ubiquitin-protein transferase activity (GO:0051438)2.92366841
117protein complex localization (GO:0031503)2.91988923
118amino acid salvage (GO:0043102)2.91687555
119L-methionine salvage (GO:0071267)2.91687555
120L-methionine biosynthetic process (GO:0071265)2.91687555
121intraciliary transport (GO:0042073)2.91517491
122establishment of viral latency (GO:0019043)2.91233995
123DNA damage response, detection of DNA damage (GO:0042769)2.90974333
124somatic hypermutation of immunoglobulin genes (GO:0016446)2.90265548
125somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90265548
126protein insertion into membrane (GO:0051205)2.89158791
127postreplication repair (GO:0006301)2.88421745
128pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88300759
129piRNA metabolic process (GO:0034587)2.87936611
130protein localization to chromosome, centromeric region (GO:0071459)2.87145284
131ubiquinone biosynthetic process (GO:0006744)2.86887492
132protein targeting to mitochondrion (GO:0006626)2.86486699
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86373174
134IMP biosynthetic process (GO:0006188)2.84464280
135negative regulation of mitotic sister chromatid separation (GO:2000816)2.83838586
136negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83838586
137negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83838586
138negative regulation of sister chromatid segregation (GO:0033046)2.83838586
139transcription-coupled nucleotide-excision repair (GO:0006283)2.81541970
140UDP-N-acetylglucosamine metabolic process (GO:0006047)2.81301747
141nuclear envelope disassembly (GO:0051081)2.80971295
142membrane disassembly (GO:0030397)2.80971295
143negative regulation of chromosome segregation (GO:0051985)2.80441151
144ubiquinone metabolic process (GO:0006743)2.75254361
145tRNA metabolic process (GO:0006399)2.74856699
146protein K11-linked ubiquitination (GO:0070979)2.74456312
147transcription elongation from RNA polymerase III promoter (GO:0006385)2.72964382
148termination of RNA polymerase III transcription (GO:0006386)2.72964382
149protein localization to mitochondrion (GO:0070585)2.72894328
150histone mRNA metabolic process (GO:0008334)2.72238273
151metallo-sulfur cluster assembly (GO:0031163)2.72121408
152iron-sulfur cluster assembly (GO:0016226)2.72121408
153RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71603054
154signal peptide processing (GO:0006465)2.69898681
155positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.69388209
156protein prenylation (GO:0018342)2.68083480
157prenylation (GO:0097354)2.68083480
158AMP metabolic process (GO:0046033)2.67637094
159respiratory electron transport chain (GO:0022904)2.65093660
160regulation of mitochondrial fission (GO:0090140)2.62950369
161establishment of protein localization to mitochondrion (GO:0072655)2.61005038
162resolution of meiotic recombination intermediates (GO:0000712)2.59459741
163anterograde synaptic vesicle transport (GO:0048490)2.59449102
164tRNA processing (GO:0008033)2.59315407
165electron transport chain (GO:0022900)2.57705050
166regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.57243186
167ncRNA catabolic process (GO:0034661)2.55800557
168kynurenine metabolic process (GO:0070189)2.55419552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.39105972
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.57746430
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.31749265
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.30862975
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34671833
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27305714
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.25346158
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17624942
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.17168610
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.16175950
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.15189200
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.11715613
13EST1_17652178_ChIP-ChIP_JURKAT_Human3.10152125
14MYC_19079543_ChIP-ChIP_MESCs_Mouse3.07742701
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98001667
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84832615
17XRN2_22483619_ChIP-Seq_HELA_Human2.72650133
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69961914
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55392006
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40424953
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40406967
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38674945
23DCP1A_22483619_ChIP-Seq_HELA_Human2.31618285
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.29090721
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28588407
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28321512
27IGF1R_20145208_ChIP-Seq_DFB_Human2.27610952
28VDR_23849224_ChIP-Seq_CD4+_Human2.25870790
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25532351
30GABP_19822575_ChIP-Seq_HepG2_Human2.22464993
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22063269
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20402273
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16583730
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16082285
35TTF2_22483619_ChIP-Seq_HELA_Human2.15619640
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14601973
37ZNF274_21170338_ChIP-Seq_K562_Hela2.13356773
38E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13253492
39FUS_26573619_Chip-Seq_HEK293_Human2.05822719
40EWS_26573619_Chip-Seq_HEK293_Human2.04804881
41FOXP3_21729870_ChIP-Seq_TREG_Human2.00883716
42MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00596925
43CIITA_25753668_ChIP-Seq_RAJI_Human1.97346473
44VDR_22108803_ChIP-Seq_LS180_Human1.93627628
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.92328731
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.90289473
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86427051
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85661792
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82403738
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.76704889
51AR_21909140_ChIP-Seq_LNCAP_Human1.76140692
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71256445
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70902160
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69128854
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69124376
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66372050
57TAF15_26573619_Chip-Seq_HEK293_Human1.66015319
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.63652135
59IRF1_19129219_ChIP-ChIP_H3396_Human1.54983179
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54812072
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50570369
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49929410
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48680867
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48015227
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.47017003
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44862808
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42515907
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41826206
69KDM5A_27292631_Chip-Seq_BREAST_Human1.36708629
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35785237
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35607914
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.35249887
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34032745
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33813980
75MYC_22102868_ChIP-Seq_BL_Human1.32631140
76P300_19829295_ChIP-Seq_ESCs_Human1.32206958
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32004861
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31607289
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31606044
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31274343
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31193028
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30374127
83ELK1_19687146_ChIP-ChIP_HELA_Human1.29722076
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28178285
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.25770351
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24449192
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23475500
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23449529
89KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22950397
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20019915
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19385151
92TP53_22573176_ChIP-Seq_HFKS_Human1.17693003
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.17030627
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16167786
95GBX2_23144817_ChIP-Seq_PC3_Human1.16028333
96MYC_18940864_ChIP-ChIP_HL60_Human1.14387196
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14128199
98TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.12833975
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12671908
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12612196
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10258716
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09879681
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09419947
104CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09339666
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07946837
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.07490444
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07482305
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07344514
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06942460
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06242445
111EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03251122
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02879500
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02632805
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02531606
115TFEB_21752829_ChIP-Seq_HELA_Human1.00290406
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00197384
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.99231744
118ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98290911
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97414104
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96647383
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96266064
122TP63_19390658_ChIP-ChIP_HaCaT_Human0.95057711
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94551065
124FOXP1_21924763_ChIP-Seq_HESCs_Human0.94493308
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93907686
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93613230
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93554140
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93111105
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92539443
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90960982
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90870323
132PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90025739
133ELK1_22589737_ChIP-Seq_MCF10A_Human0.89620207
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89604091
135ER_23166858_ChIP-Seq_MCF-7_Human0.89148062
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88317842
137PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87348010
138NANOG_21062744_ChIP-ChIP_HESCs_Human0.86896254
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86384569
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86211867
141NANOG_16153702_ChIP-ChIP_HESCs_Human0.85526671
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85180555
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85163765
144JUN_21703547_ChIP-Seq_K562_Human0.84421515
145ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84064215
146CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83737675
147YY1_22570637_ChIP-Seq_MALME-3M_Human0.83608212

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation5.44496226
2MP0003693_abnormal_embryo_hatching4.42990183
3MP0004957_abnormal_blastocyst_morpholog3.64551268
4MP0010094_abnormal_chromosome_stability3.62368462
5MP0003111_abnormal_nucleus_morphology3.52601541
6MP0003077_abnormal_cell_cycle3.20751895
7MP0000569_abnormal_digit_pigmentation2.89847389
8MP0008058_abnormal_DNA_repair2.79799819
9MP0008877_abnormal_DNA_methylation2.76124533
10MP0008932_abnormal_embryonic_tissue2.72720064
11MP0003123_paternal_imprinting2.67971608
12MP0002837_dystrophic_cardiac_calcinosis2.56024432
13MP0008007_abnormal_cellular_replicative2.39258433
14MP0003806_abnormal_nucleotide_metabolis2.35816616
15MP0000372_irregular_coat_pigmentation2.34675843
16MP0010030_abnormal_orbit_morphology2.30319243
17MP0008057_abnormal_DNA_replication2.24093049
18MP0003186_abnormal_redox_activity2.24065833
19MP0003950_abnormal_plasma_membrane2.18561033
20MP0001730_embryonic_growth_arrest2.17651399
21MP0001984_abnormal_olfaction2.05834359
22MP0002653_abnormal_ependyma_morphology1.93848394
23MP0008789_abnormal_olfactory_epithelium1.93141765
24MP0005645_abnormal_hypothalamus_physiol1.91604103
25MP0010352_gastrointestinal_tract_polyps1.88974676
26MP0004215_abnormal_myocardial_fiber1.85720333
27MP0000350_abnormal_cell_proliferation1.84918666
28MP0002160_abnormal_reproductive_system1.76415036
29MP0006072_abnormal_retinal_apoptosis1.75137073
30MP0005499_abnormal_olfactory_system1.70308297
31MP0005394_taste/olfaction_phenotype1.70308297
32MP0003195_calcinosis1.68393176
33MP0001697_abnormal_embryo_size1.67178567
34MP0004145_abnormal_muscle_electrophysio1.65888428
35MP0003121_genomic_imprinting1.65501569
36MP0002163_abnormal_gland_morphology1.63755589
37MP0002138_abnormal_hepatobiliary_system1.59049765
38MP0002751_abnormal_autonomic_nervous1.58278550
39MP0006276_abnormal_autonomic_nervous1.56631864
40MP0004133_heterotaxia1.52434403
41MP0004233_abnormal_muscle_weight1.52030241
42MP0002102_abnormal_ear_morphology1.50307510
43MP0000537_abnormal_urethra_morphology1.46557302
44MP0003315_abnormal_perineum_morphology1.45740337
45MP0003890_abnormal_embryonic-extraembry1.45155892
46MP0005084_abnormal_gallbladder_morpholo1.44752717
47MP0003122_maternal_imprinting1.42623797
48MP0002080_prenatal_lethality1.41186508
49MP0002876_abnormal_thyroid_physiology1.36844862
50MP0002085_abnormal_embryonic_tissue1.34180240
51MP0002735_abnormal_chemical_nociception1.33758604
52MP0001672_abnormal_embryogenesis/_devel1.32817634
53MP0005380_embryogenesis_phenotype1.32817634
54MP0002184_abnormal_innervation1.32164695
55MP0000358_abnormal_cell_content/1.30676272
56MP0003786_premature_aging1.30124993
57MP0002084_abnormal_developmental_patter1.30075364
58MP0000313_abnormal_cell_death1.29298787
59MP0003787_abnormal_imprinting1.28591286
60MP0000013_abnormal_adipose_tissue1.26937330
61MP0006035_abnormal_mitochondrial_morpho1.26852366
62MP0003984_embryonic_growth_retardation1.23611325
63MP0000647_abnormal_sebaceous_gland1.22960861
64MP0002210_abnormal_sex_determination1.22960644
65MP0001968_abnormal_touch/_nociception1.22960291
66MP0005187_abnormal_penis_morphology1.22550109
67MP0001293_anophthalmia1.21472319
68MP0005410_abnormal_fertilization1.21141759
69MP0001529_abnormal_vocalization1.20215166
70MP0002088_abnormal_embryonic_growth/wei1.19631794
71MP0005253_abnormal_eye_physiology1.18724754
72MP0010307_abnormal_tumor_latency1.17407534
73MP0003646_muscle_fatigue1.17239388
74MP0005083_abnormal_biliary_tract1.16622191
75MP0003119_abnormal_digestive_system1.16433816
76MP0004036_abnormal_muscle_relaxation1.16417169
77MP0003221_abnormal_cardiomyocyte_apopto1.14773148
78MP0002736_abnormal_nociception_after1.13824953
79MP0004811_abnormal_neuron_physiology1.13507433
80MP0001929_abnormal_gametogenesis1.12977290
81MP0002396_abnormal_hematopoietic_system1.11006693
82MP0001145_abnormal_male_reproductive1.10628725
83MP0008872_abnormal_physiological_respon1.10621951
84MP0003861_abnormal_nervous_system1.06428408
85MP0004147_increased_porphyrin_level1.04943670
86MP0006054_spinal_hemorrhage1.03013114
87MP0000427_abnormal_hair_cycle1.02847108
88MP0005379_endocrine/exocrine_gland_phen1.01466132
89MP0001764_abnormal_homeostasis1.00114561
90MP0002638_abnormal_pupillary_reflex1.00076913
91MP0001188_hyperpigmentation0.99566588
92MP0003698_abnormal_male_reproductive0.98781740
93MP0003880_abnormal_central_pattern0.98743937
94MP0006292_abnormal_olfactory_placode0.97689852
95MP0004858_abnormal_nervous_system0.97080437
96MP0005171_absent_coat_pigmentation0.96671823
97MP0003941_abnormal_skin_development0.94861471
98MP0002019_abnormal_tumor_incidence0.94723354
99MP0004197_abnormal_fetal_growth/weight/0.92433275
100MP0000490_abnormal_crypts_of0.90355809
101MP0004859_abnormal_synaptic_plasticity0.89994586
102MP0004142_abnormal_muscle_tone0.89808570
103MP0005389_reproductive_system_phenotype0.89169947
104MP0000653_abnormal_sex_gland0.87347526
105MP0002734_abnormal_mechanical_nocicepti0.87257739
106MP0001986_abnormal_taste_sensitivity0.86778297
107MP0005266_abnormal_metabolism0.86753315
108MP0008775_abnormal_heart_ventricle0.86375604
109MP0010386_abnormal_urinary_bladder0.85640770
110MP0003942_abnormal_urinary_system0.83396770
111MP0009333_abnormal_splenocyte_physiolog0.83280057
112MP0003937_abnormal_limbs/digits/tail_de0.83093382
113MP0009046_muscle_twitch0.83036312
114MP0002086_abnormal_extraembryonic_tissu0.80424658
115MP0001542_abnormal_bone_strength0.79920577
116MP0004808_abnormal_hematopoietic_stem0.79833419
117MP0008438_abnormal_cutaneous_collagen0.79680633
118MP0002090_abnormal_vision0.79103843
119MP0003567_abnormal_fetal_cardiomyocyte0.78796671
120MP0009672_abnormal_birth_weight0.77821586
121MP0001243_abnormal_dermal_layer0.77375077
122MP0006036_abnormal_mitochondrial_physio0.77139292
123MP0004084_abnormal_cardiac_muscle0.76922457
124MP0004270_analgesia0.76810010
125MP0003283_abnormal_digestive_organ0.75833267
126MP0004924_abnormal_behavior0.75079955
127MP0005386_behavior/neurological_phenoty0.75079955
128MP0002234_abnormal_pharynx_morphology0.74830500
129MP0000049_abnormal_middle_ear0.74767126
130MP0008770_decreased_survivor_rate0.74000455
131MP0002332_abnormal_exercise_endurance0.73570390
132MP0002972_abnormal_cardiac_muscle0.72758521
133MP0003635_abnormal_synaptic_transmissio0.72288595
134MP0005332_abnormal_amino_acid0.72231029
135MP0002161_abnormal_fertility/fecundity0.71645302
136MP0002152_abnormal_brain_morphology0.70840956
137MP0002938_white_spotting0.70559223
138MP0009053_abnormal_anal_canal0.69803458
139MP0003718_maternal_effect0.69704765
140MP0002269_muscular_atrophy0.69504891
141MP0005384_cellular_phenotype0.69491765
142MP0000778_abnormal_nervous_system0.68113173
143MP0001348_abnormal_lacrimal_gland0.67484917
144MP0005551_abnormal_eye_electrophysiolog0.66267494
145MP0005451_abnormal_body_composition0.65843277
146MP0000749_muscle_degeneration0.65498656
147MP0000703_abnormal_thymus_morphology0.64959873
148MP0005408_hypopigmentation0.64670179
149MP0002752_abnormal_somatic_nervous0.64630993
150MP0004134_abnormal_chest_morphology0.64599527
151MP0005395_other_phenotype0.64424087
152MP0000750_abnormal_muscle_regeneration0.64384429
153MP0005623_abnormal_meninges_morphology0.63743721
154MP0003137_abnormal_impulse_conducting0.63641120
155MP0000858_altered_metastatic_potential0.62502906
156MP0005391_vision/eye_phenotype0.61587586
157MP0002177_abnormal_outer_ear0.61119324
158MP0002139_abnormal_hepatobiliary_system0.60902414

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)4.02626402
2Abnormality of the anterior horn cell (HP:0006802)3.94667874
3Degeneration of anterior horn cells (HP:0002398)3.94667874
4Birth length less than 3rd percentile (HP:0003561)3.79380588
5Abnormality of cells of the erythroid lineage (HP:0012130)3.43879260
6Abnormal number of erythroid precursors (HP:0012131)3.19748532
7Cerebral hypomyelination (HP:0006808)3.11334877
8Colon cancer (HP:0003003)3.10416983
9Lipid accumulation in hepatocytes (HP:0006561)3.10104120
10Methylmalonic acidemia (HP:0002912)3.06902558
11Abnormality of glycolysis (HP:0004366)3.04576949
12Increased serum pyruvate (HP:0003542)3.04576949
13Cerebral edema (HP:0002181)2.99741912
14Oral leukoplakia (HP:0002745)2.91739593
15Acute necrotizing encephalopathy (HP:0006965)2.90108960
16Hepatic necrosis (HP:0002605)2.85457935
17Carpal bone hypoplasia (HP:0001498)2.84702757
18Abnormality of serum amino acid levels (HP:0003112)2.80366132
19Abnormal mitochondria in muscle tissue (HP:0008316)2.80090744
20Aplastic anemia (HP:0001915)2.80020140
21Atrophy/Degeneration involving motor neurons (HP:0007373)2.73526059
22Patellar aplasia (HP:0006443)2.71724411
23Rough bone trabeculation (HP:0100670)2.69024772
24Medial flaring of the eyebrow (HP:0010747)2.68938392
25Hyperglycinemia (HP:0002154)2.68300227
26Pelvic girdle muscle weakness (HP:0003749)2.63645865
27Methylmalonic aciduria (HP:0012120)2.59918747
28Aplasia/Hypoplasia of the patella (HP:0006498)2.55009240
29Increased intramyocellular lipid droplets (HP:0012240)2.53839424
30Shoulder girdle muscle weakness (HP:0003547)2.52969509
31Reticulocytopenia (HP:0001896)2.50845262
32Renal cortical cysts (HP:0000803)2.50747128
33Selective tooth agenesis (HP:0001592)2.50716132
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49274879
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49274879
36Delayed gross motor development (HP:0002194)2.46027566
37Mitochondrial inheritance (HP:0001427)2.42447945
38Breast hypoplasia (HP:0003187)2.42020428
39Increased CSF lactate (HP:0002490)2.40265297
40Hypothermia (HP:0002045)2.38631990
41Increased serum lactate (HP:0002151)2.38188829
42Abnormality of midbrain morphology (HP:0002418)2.37661317
43Molar tooth sign on MRI (HP:0002419)2.37661317
44B lymphocytopenia (HP:0010976)2.37448793
45Abnormality of the musculature of the pelvis (HP:0001469)2.37300841
46Abnormality of the hip-girdle musculature (HP:0001445)2.37300841
47Microretrognathia (HP:0000308)2.35936933
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35438448
49Abnormality of alanine metabolism (HP:0010916)2.35438448
50Hyperalaninemia (HP:0003348)2.35438448
51Progressive macrocephaly (HP:0004481)2.30405486
52Unsteady gait (HP:0002317)2.29685630
53Pancreatic fibrosis (HP:0100732)2.26552813
54Thyroiditis (HP:0100646)2.25412784
55Hypoplasia of the pons (HP:0012110)2.22768396
56Abnormality of the renal cortex (HP:0011035)2.21827345
57Abnormality of methionine metabolism (HP:0010901)2.20936264
58Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.18775209
59Adenoma sebaceum (HP:0009720)2.17836201
60Angiofibromas (HP:0010615)2.17836201
61Abnormality of B cell number (HP:0010975)2.16874830
62Lethargy (HP:0001254)2.15558187
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14323192
64Trismus (HP:0000211)2.13352581
65Renal Fanconi syndrome (HP:0001994)2.13199337
66Hepatocellular necrosis (HP:0001404)2.12617974
67Premature graying of hair (HP:0002216)2.11964600
68Medulloblastoma (HP:0002885)2.11852631
69Myokymia (HP:0002411)2.11622982
70Supernumerary spleens (HP:0009799)2.11048200
71Type II lissencephaly (HP:0007260)2.10947191
72Cleft eyelid (HP:0000625)2.10351462
73Atresia of the external auditory canal (HP:0000413)2.10230652
74Pancreatic cysts (HP:0001737)2.09349896
7511 pairs of ribs (HP:0000878)2.07821950
76Neoplasm of the pancreas (HP:0002894)2.07380127
77Exercise-induced muscle cramps (HP:0003710)2.05652938
78Optic nerve coloboma (HP:0000588)2.05299258
79Emotional lability (HP:0000712)2.04583708
80Type I transferrin isoform profile (HP:0003642)2.04182308
81CNS demyelination (HP:0007305)2.03996145
82Nephrogenic diabetes insipidus (HP:0009806)2.03962383
83Myoglobinuria (HP:0002913)2.03212729
84Abnormality of the pons (HP:0007361)2.02803459
85Exercise intolerance (HP:0003546)2.02297490
86Inability to walk (HP:0002540)2.02034860
87Abnormal number of incisors (HP:0011064)2.00949910
88Increased muscle lipid content (HP:0009058)1.99797084
89Postnatal microcephaly (HP:0005484)1.99507561
90Abnormal protein glycosylation (HP:0012346)1.99248832
91Abnormal glycosylation (HP:0012345)1.99248832
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99248832
93Abnormal protein N-linked glycosylation (HP:0012347)1.99248832
94Volvulus (HP:0002580)1.97463271
95Absent thumb (HP:0009777)1.96628903
96Cerebellar dysplasia (HP:0007033)1.96198896
97Severe combined immunodeficiency (HP:0004430)1.95318680
98Cortical dysplasia (HP:0002539)1.95258540
99Microvesicular hepatic steatosis (HP:0001414)1.94009624
100Facial cleft (HP:0002006)1.92708644
101Abnormality of the vitamin B12 metabolism (HP:0004341)1.92494177
102Upper limb muscle weakness (HP:0003484)1.92058881
103Optic disc pallor (HP:0000543)1.90889400
104Pallor (HP:0000980)1.89873315
105Acute encephalopathy (HP:0006846)1.89135981
106Lissencephaly (HP:0001339)1.88878127
107Aplasia/Hypoplasia of the sternum (HP:0006714)1.88596233
108Progressive inability to walk (HP:0002505)1.88494981
109Abnormal lung lobation (HP:0002101)1.88050083
110Abnormality of vitamin B metabolism (HP:0004340)1.87554681
111Congenital primary aphakia (HP:0007707)1.87384397
112Redundant skin (HP:0001582)1.84682100
113Abdominal situs inversus (HP:0003363)1.82518169
114Abnormality of abdominal situs (HP:0011620)1.82518169
115Poor head control (HP:0002421)1.82024916
116Hypoproteinemia (HP:0003075)1.81367479
117True hermaphroditism (HP:0010459)1.79962652
118Hypoplasia of the thymus (HP:0000778)1.77627615
119Neoplasm of the colon (HP:0100273)1.77084057
120Meckel diverticulum (HP:0002245)1.76894099
121Drooling (HP:0002307)1.76622925
122Gait imbalance (HP:0002141)1.76137871
123Macrocytic anemia (HP:0001972)1.76094462
124Neuroendocrine neoplasm (HP:0100634)1.75558498
125Bifid tongue (HP:0010297)1.75196242
126Neuroblastic tumors (HP:0004376)1.74327474
127Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.74327474
128Neuroblastoma (HP:0003006)1.74327474
129Primitive neuroectodermal tumor (HP:0030065)1.74327474
130Limb-girdle muscle atrophy (HP:0003797)1.74206587
131Abnormal trabecular bone morphology (HP:0100671)1.73939356
132Increased hepatocellular lipid droplets (HP:0006565)1.73855899
133Cellular immunodeficiency (HP:0005374)1.73155806
134Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73150226
135Abnormality of the ileum (HP:0001549)1.72541117
136Horseshoe kidney (HP:0000085)1.72169712
137Fair hair (HP:0002286)1.71901765
138Lactic acidosis (HP:0003128)1.71346211
139Glycosuria (HP:0003076)1.71260791
140Abnormality of urine glucose concentration (HP:0011016)1.71260791
141IgG deficiency (HP:0004315)1.70643887
142Irregular epiphyses (HP:0010582)1.70616895
143Aplasia/hypoplasia of the uterus (HP:0008684)1.70068797
144Increased nuchal translucency (HP:0010880)1.69965884
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69961825
146Combined immunodeficiency (HP:0005387)1.69125851
147Agnosia (HP:0010524)1.68688191
148Delusions (HP:0000746)1.68027829
149Hypoplasia of the uterus (HP:0000013)1.67171722
150Aplasia/Hypoplasia of the tibia (HP:0005772)1.66179453
151Reduced antithrombin III activity (HP:0001976)1.65434457
152Duodenal stenosis (HP:0100867)1.63747053
153Small intestinal stenosis (HP:0012848)1.63747053
154Abolished electroretinogram (ERG) (HP:0000550)1.63575239
155Glossoptosis (HP:0000162)1.63217887
156Tongue fasciculations (HP:0001308)1.62830472
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.61534016
158Premature ovarian failure (HP:0008209)1.60306838
159CNS hypomyelination (HP:0003429)1.59640743
160Tracheoesophageal fistula (HP:0002575)1.58942758
161Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.58552927
162Severe visual impairment (HP:0001141)1.58498367
163Neoplasm of the peripheral nervous system (HP:0100007)1.57818239
164Abnormality of the labia minora (HP:0012880)1.57248340
165Freckling (HP:0001480)1.57059026
166Ependymoma (HP:0002888)1.56430832
167Respiratory failure (HP:0002878)1.56252468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.84660885
2CDC73.90696286
3WEE13.33460499
4TRIM283.07083987
5NEK12.87529948
6EIF2AK12.82345646
7BCR2.76956030
8TESK12.55484804
9MAP3K102.36001624
10SCYL22.26599333
11FRK2.15867641
12BRAF2.14402585
13DYRK32.08493454
14NUAK12.07658946
15MINK12.07384973
16NEK22.03535978
17BMPR1B2.00582198
18NME21.99727106
19ARAF1.95713031
20LIMK11.94779086
21EPHA31.90733937
22PDK21.88279576
23MST41.86419217
24TESK21.82369298
25STK161.82155411
26PINK11.80172674
27TTK1.69716412
28RPS6KA41.65356047
29BRSK21.60230976
30SRPK11.58281618
31PLK11.57871057
32AURKA1.57027574
33TNIK1.56087819
34MAP3K111.54733870
35ZAK1.53053900
36CCNB11.52811317
37TLK11.52739525
38BRSK11.50936917
39ACVR1B1.50930403
40LATS21.48205951
41EIF2AK31.40002113
42ADRBK21.37561668
43CSNK1G31.37357948
44PLK41.35886867
45PLK31.34161822
46PIM21.31373496
47CSNK1G21.30385259
48BCKDK1.29956192
49PBK1.27094669
50MAP4K21.25391257
51TSSK61.23703064
52NME11.22960098
53CSNK1G11.22043320
54CDK71.20797774
55CDK191.19630580
56KSR11.19200021
57ATR1.19109267
58MAPKAPK31.17883352
59CSNK1A1L1.13150955
60AURKB1.10817551
61WNK31.10258846
62CHEK21.06301285
63STK38L1.03879768
64PIK3CG0.99781137
65PASK0.99472218
66STK390.99445038
67VRK10.99282064
68MAP3K80.98810149
69MKNK10.98622732
70RPS6KA50.98011950
71CAMKK20.97340193
72PAK30.96192260
73DAPK10.95331682
74PAK10.93806255
75RPS6KB20.93737553
76MAP3K90.92845337
77PDK40.91386326
78PDK30.91386326
79GRK10.90447259
80CASK0.90363589
81TAOK30.89538841
82OBSCN0.88502196
83DYRK20.87106654
84ERBB40.86979775
85CDK140.84905172
86MAP2K40.84367211
87CDK80.84202990
88RAF10.83174899
89ILK0.79814788
90CDK180.79318751
91PRKCE0.78313696
92PKN20.78050555
93STK40.75842136
94WNK40.74491335
95OXSR10.73215330
96CDK11A0.71824880
97MAP3K40.71220566
98MAP3K120.71130835
99CDK150.70737517
100ERBB30.69532142
101PRKD30.69223947
102TIE10.68967696
103CHEK10.68479616
104PAK40.68333887
105PLK20.66595098
106CDK40.64808763
107MAP3K50.63386950
108FLT30.60267718
109TAF10.59111390
110CDK20.59037403
111PRKCI0.58200996
112KSR20.58041690
113EEF2K0.56446405
114STK30.55265529
115TGFBR10.53013803
116SIK30.52925433
117MARK10.51183932
118CSNK2A10.49152725
119CSNK2A20.47550084
120MAP2K70.47447621
121GRK60.46773839
122KDR0.46672157
123TRPM70.45687854
124PHKG10.45675317
125PHKG20.45675317
126DAPK30.45674767
127LRRK20.45170855
128FGFR10.43494587
129TXK0.43262567
130ATM0.42319968
131LATS10.39700041
132MAPK130.39346119
133CDK10.39209671
134TAOK20.39128099
135NEK90.35985706
136UHMK10.35592514
137AKT30.35256901
138PAK60.34975600
139EIF2AK20.34400544
140CAMK2A0.33635071
141PNCK0.33594566
142TAOK10.33409975
143AKT20.32975157
144PRKCG0.32419598
145PRKCQ0.32224995
146NTRK30.31694224
147CSNK1E0.26790651
148MKNK20.25884909

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.49050894
2Proteasome_Homo sapiens_hsa030504.07131424
3Mismatch repair_Homo sapiens_hsa034303.36807715
4Ribosome_Homo sapiens_hsa030103.18208447
5Spliceosome_Homo sapiens_hsa030402.99715444
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86968830
7Base excision repair_Homo sapiens_hsa034102.79856906
8RNA polymerase_Homo sapiens_hsa030202.78767217
9RNA transport_Homo sapiens_hsa030132.76301270
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43443636
11Cell cycle_Homo sapiens_hsa041102.42142537
12Selenocompound metabolism_Homo sapiens_hsa004502.34346615
13Pyrimidine metabolism_Homo sapiens_hsa002402.29775801
14Nucleotide excision repair_Homo sapiens_hsa034202.27573218
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23725775
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22697320
17Homologous recombination_Homo sapiens_hsa034402.19318782
18Parkinsons disease_Homo sapiens_hsa050122.08919374
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96682074
20Propanoate metabolism_Homo sapiens_hsa006401.88596534
21Huntingtons disease_Homo sapiens_hsa050161.83233153
22Oxidative phosphorylation_Homo sapiens_hsa001901.78944254
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74673846
24Oocyte meiosis_Homo sapiens_hsa041141.74535613
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73569331
26Sulfur metabolism_Homo sapiens_hsa009201.66454495
27RNA degradation_Homo sapiens_hsa030181.64600670
28mRNA surveillance pathway_Homo sapiens_hsa030151.61102997
29Non-homologous end-joining_Homo sapiens_hsa034501.51369474
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45600262
31Peroxisome_Homo sapiens_hsa041461.41823278
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38275270
33Basal transcription factors_Homo sapiens_hsa030221.38057774
34Fanconi anemia pathway_Homo sapiens_hsa034601.37810545
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37052121
36Butanoate metabolism_Homo sapiens_hsa006501.36173928
37Purine metabolism_Homo sapiens_hsa002301.35767382
38Fatty acid elongation_Homo sapiens_hsa000621.23562537
39Cardiac muscle contraction_Homo sapiens_hsa042601.21301682
40Olfactory transduction_Homo sapiens_hsa047401.21112666
41One carbon pool by folate_Homo sapiens_hsa006701.21029904
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18706557
43Alzheimers disease_Homo sapiens_hsa050101.18437177
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15619040
45Steroid biosynthesis_Homo sapiens_hsa001001.15112587
46Epstein-Barr virus infection_Homo sapiens_hsa051691.14218681
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10099600
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08174043
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04835850
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03472850
51Regulation of autophagy_Homo sapiens_hsa041401.02602538
52p53 signaling pathway_Homo sapiens_hsa041151.00211501
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.98445633
54Thyroid cancer_Homo sapiens_hsa052160.97086468
55Synaptic vesicle cycle_Homo sapiens_hsa047210.96203631
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89275921
57Collecting duct acid secretion_Homo sapiens_hsa049660.88315060
58Circadian rhythm_Homo sapiens_hsa047100.80600524
59Metabolic pathways_Homo sapiens_hsa011000.79053840
60Tryptophan metabolism_Homo sapiens_hsa003800.78621778
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78520091
62Shigellosis_Homo sapiens_hsa051310.75474513
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74401354
64Alcoholism_Homo sapiens_hsa050340.73607955
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73005077
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.70403127
67Colorectal cancer_Homo sapiens_hsa052100.70182484
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69529685
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66290635
70Viral carcinogenesis_Homo sapiens_hsa052030.65980505
71Hedgehog signaling pathway_Homo sapiens_hsa043400.63572271
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62083638
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61781570
74HTLV-I infection_Homo sapiens_hsa051660.61313942
75Biosynthesis of amino acids_Homo sapiens_hsa012300.61180065
76N-Glycan biosynthesis_Homo sapiens_hsa005100.60394010
77Systemic lupus erythematosus_Homo sapiens_hsa053220.59681175
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.59598516
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.58654841
80Hippo signaling pathway_Homo sapiens_hsa043900.58265950
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57620928
82Arginine and proline metabolism_Homo sapiens_hsa003300.57551154
83Long-term potentiation_Homo sapiens_hsa047200.56060110
84Dopaminergic synapse_Homo sapiens_hsa047280.51948470
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49905792
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49290891
87Gap junction_Homo sapiens_hsa045400.49010164
88Fatty acid metabolism_Homo sapiens_hsa012120.48514125
89Carbon metabolism_Homo sapiens_hsa012000.47663133
90Nitrogen metabolism_Homo sapiens_hsa009100.46983919
91Folate biosynthesis_Homo sapiens_hsa007900.46935346
92Basal cell carcinoma_Homo sapiens_hsa052170.46886887
93Pentose phosphate pathway_Homo sapiens_hsa000300.44517980
94Melanoma_Homo sapiens_hsa052180.44045875
95Vibrio cholerae infection_Homo sapiens_hsa051100.43921264
96Bladder cancer_Homo sapiens_hsa052190.43581051
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43246985
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42953753
99Phototransduction_Homo sapiens_hsa047440.42465550
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39897592
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39349478
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39058747
103HIF-1 signaling pathway_Homo sapiens_hsa040660.38333405
104Protein export_Homo sapiens_hsa030600.37526279
105Glioma_Homo sapiens_hsa052140.37505965
106beta-Alanine metabolism_Homo sapiens_hsa004100.36652568
107Sulfur relay system_Homo sapiens_hsa041220.35580543
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35576131
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.35122398
110Chronic myeloid leukemia_Homo sapiens_hsa052200.32234157
111Herpes simplex infection_Homo sapiens_hsa051680.32036882
112Primary immunodeficiency_Homo sapiens_hsa053400.31995169
113Caffeine metabolism_Homo sapiens_hsa002320.31587120
114Non-small cell lung cancer_Homo sapiens_hsa052230.30805805
115VEGF signaling pathway_Homo sapiens_hsa043700.30713619
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30525218
117Apoptosis_Homo sapiens_hsa042100.28792996
118Fructose and mannose metabolism_Homo sapiens_hsa000510.28312001
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.27940685
120Endometrial cancer_Homo sapiens_hsa052130.27396898
121Wnt signaling pathway_Homo sapiens_hsa043100.27266998
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27143000
123Melanogenesis_Homo sapiens_hsa049160.27055704
124Mineral absorption_Homo sapiens_hsa049780.26864515
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26757875
126MicroRNAs in cancer_Homo sapiens_hsa052060.26089223
127TGF-beta signaling pathway_Homo sapiens_hsa043500.25146685
128Salmonella infection_Homo sapiens_hsa051320.24719919
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24263165
130Legionellosis_Homo sapiens_hsa051340.24143615
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24103461
132Renin-angiotensin system_Homo sapiens_hsa046140.22491084
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.22259149
134Amphetamine addiction_Homo sapiens_hsa050310.21252085
135Rheumatoid arthritis_Homo sapiens_hsa053230.21180799
136mTOR signaling pathway_Homo sapiens_hsa041500.20717849
137Glucagon signaling pathway_Homo sapiens_hsa049220.20100235
138Pyruvate metabolism_Homo sapiens_hsa006200.20039748
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19843516
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19388698
141Viral myocarditis_Homo sapiens_hsa054160.18591936
142Glutathione metabolism_Homo sapiens_hsa004800.18570164
143Pathways in cancer_Homo sapiens_hsa052000.18248001
144Hepatitis B_Homo sapiens_hsa051610.18228047
145Nicotine addiction_Homo sapiens_hsa050330.17522430
146Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17260395
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14423755
148Fatty acid degradation_Homo sapiens_hsa000710.14371885

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