RTCB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1homocysteine metabolic process (GO:0050667)6.08456685
2ribosomal small subunit assembly (GO:0000028)5.85452400
3formation of translation preinitiation complex (GO:0001731)5.63860464
4L-serine metabolic process (GO:0006563)5.52784573
5pteridine-containing compound biosynthetic process (GO:0042559)5.20685083
6DNA unwinding involved in DNA replication (GO:0006268)5.04321870
7proteasome assembly (GO:0043248)5.01672595
8mitochondrial RNA metabolic process (GO:0000959)4.87915450
9purine nucleotide salvage (GO:0032261)4.87092731
10regulation of plasminogen activation (GO:0010755)4.74689027
11nucleobase biosynthetic process (GO:0046112)4.65343170
12IMP biosynthetic process (GO:0006188)4.64840278
13viral transcription (GO:0019083)4.63268479
14maturation of SSU-rRNA (GO:0030490)4.59068989
15sulfur amino acid catabolic process (GO:0000098)4.58980811
16translational termination (GO:0006415)4.51110411
17CENP-A containing nucleosome assembly (GO:0034080)4.48765001
18chromatin remodeling at centromere (GO:0031055)4.44142446
19folic acid-containing compound biosynthetic process (GO:0009396)4.39128140
20translational elongation (GO:0006414)4.37866881
21Golgi transport vesicle coating (GO:0048200)4.29878551
22COPI coating of Golgi vesicle (GO:0048205)4.29878551
23adenosine metabolic process (GO:0046085)4.29580687
24purine nucleobase biosynthetic process (GO:0009113)4.27030725
25serine family amino acid biosynthetic process (GO:0009070)4.20816904
26rRNA modification (GO:0000154)4.18627637
27DNA ligation (GO:0006266)4.16193672
28cysteine metabolic process (GO:0006534)4.14112499
29DNA strand elongation involved in DNA replication (GO:0006271)4.11219102
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.09368304
31translational initiation (GO:0006413)4.03157700
32tetrahydrofolate metabolic process (GO:0046653)4.00428479
33cotranslational protein targeting to membrane (GO:0006613)3.97193535
34protein targeting to ER (GO:0045047)3.95632263
35IMP metabolic process (GO:0046040)3.95158501
36DNA strand elongation (GO:0022616)3.94657970
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.89738689
38rRNA methylation (GO:0031167)3.87319483
39protein localization to kinetochore (GO:0034501)3.82152090
40pseudouridine synthesis (GO:0001522)3.82085042
41regulation of cellular amino acid metabolic process (GO:0006521)3.75990237
42protein localization to endoplasmic reticulum (GO:0070972)3.73021046
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.72894464
44cullin deneddylation (GO:0010388)3.68999725
45cellular protein complex disassembly (GO:0043624)3.68926238
46telomere maintenance via semi-conservative replication (GO:0032201)3.68819091
47DNA replication initiation (GO:0006270)3.66085027
48folic acid-containing compound metabolic process (GO:0006760)3.64829650
49mitotic nuclear envelope disassembly (GO:0007077)3.63941052
50viral life cycle (GO:0019058)3.63063552
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.62946832
52peptidyl-arginine omega-N-methylation (GO:0035247)3.60819630
53histone exchange (GO:0043486)3.57414774
54ribosomal small subunit biogenesis (GO:0042274)3.57249559
55regulation of translational fidelity (GO:0006450)3.56749756
56galactose catabolic process (GO:0019388)3.56364104
57ribosomal large subunit biogenesis (GO:0042273)3.53897135
58tRNA aminoacylation for protein translation (GO:0006418)3.52150938
59negative regulation of RNA splicing (GO:0033119)3.50186874
60protein deneddylation (GO:0000338)3.49892946
61tRNA aminoacylation (GO:0043039)3.46240905
62amino acid activation (GO:0043038)3.46240905
63signal transduction involved in cell cycle checkpoint (GO:0072395)3.46084067
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.46023267
65NADH dehydrogenase complex assembly (GO:0010257)3.46023267
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.46023267
67ribosome biogenesis (GO:0042254)3.45255862
68ribonucleoprotein complex biogenesis (GO:0022613)3.45230528
69protein complex disassembly (GO:0043241)3.44880336
70DNA replication-independent nucleosome assembly (GO:0006336)3.42674723
71DNA replication-independent nucleosome organization (GO:0034724)3.42674723
72protein-cofactor linkage (GO:0018065)3.42336566
73negative regulation of DNA biosynthetic process (GO:2000279)3.42165668
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.41111426
75nuclear envelope disassembly (GO:0051081)3.40217409
76membrane disassembly (GO:0030397)3.40217409
77somatic hypermutation of immunoglobulin genes (GO:0016446)3.38232987
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.38232987
79inner mitochondrial membrane organization (GO:0007007)3.33486917
80macromolecular complex disassembly (GO:0032984)3.27989605
81de novo posttranslational protein folding (GO:0051084)3.27315594
82alternative mRNA splicing, via spliceosome (GO:0000380)3.26940375
83postreplication repair (GO:0006301)3.25875528
84DNA replication-dependent nucleosome organization (GO:0034723)3.25782370
85DNA replication-dependent nucleosome assembly (GO:0006335)3.25782370
86de novo protein folding (GO:0006458)3.25309946
87tRNA modification (GO:0006400)3.24802095
88establishment of integrated proviral latency (GO:0075713)3.24589205
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24292755
90pteridine-containing compound metabolic process (GO:0042558)3.21393372
91sulfur amino acid biosynthetic process (GO:0000097)3.20725839
92nuclear-transcribed mRNA catabolic process (GO:0000956)3.20335132
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20057422
94regulation of vitamin D biosynthetic process (GO:0060556)3.19378436
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18792787
96spliceosomal snRNP assembly (GO:0000387)3.16635899
97translation (GO:0006412)3.15647161
98GMP metabolic process (GO:0046037)3.13334283
99histone arginine methylation (GO:0034969)3.12851114
100DNA duplex unwinding (GO:0032508)3.12726923
101protein complex biogenesis (GO:0070271)3.11645882
102negative regulation of ligase activity (GO:0051352)3.10030177
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10030177
104regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.09960749
105telomere maintenance via recombination (GO:0000722)3.08763546
106DNA geometric change (GO:0032392)3.08756453
107microtubule nucleation (GO:0007020)3.07756803
108DNA replication checkpoint (GO:0000076)3.06492481
109telomere maintenance via telomere lengthening (GO:0010833)3.04769938
110viral mRNA export from host cell nucleus (GO:0046784)3.04756530
111transcription from mitochondrial promoter (GO:0006390)3.04610286
112establishment of viral latency (GO:0019043)3.04551868
113COPII vesicle coating (GO:0048208)3.04094590
114positive regulation of ligase activity (GO:0051351)3.02440245
115mRNA catabolic process (GO:0006402)3.01979926
116mitochondrial respiratory chain complex assembly (GO:0033108)3.00272077
117desmosome organization (GO:0002934)2.99976183
118regulation of translational termination (GO:0006449)2.99903576
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.99237291
120RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.98849684
121mRNA splicing, via spliceosome (GO:0000398)2.98849684
122mitotic recombination (GO:0006312)2.97679220
123nucleobase-containing small molecule interconversion (GO:0015949)2.95616753
124rRNA processing (GO:0006364)2.95506087
125histone H2A acetylation (GO:0043968)2.95449257
126chaperone-mediated protein transport (GO:0072321)2.95370179
127respiratory chain complex IV assembly (GO:0008535)2.95242522
128RNA splicing, via transesterification reactions (GO:0000375)2.94702998
129nucleotide salvage (GO:0043173)2.94676055
130RNA catabolic process (GO:0006401)2.94650712
131peptidyl-arginine methylation (GO:0018216)2.93990429
132peptidyl-arginine N-methylation (GO:0035246)2.93990429
133galactose metabolic process (GO:0006012)2.93825848
134activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.92731529
135regulation of ubiquitin-protein transferase activity (GO:0051438)2.91930602
136maturation of 5.8S rRNA (GO:0000460)2.91783351
137glycoside metabolic process (GO:0016137)2.90199715
138DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89706916
139negative regulation of telomerase activity (GO:0051974)2.89228131
140platelet dense granule organization (GO:0060155)2.88631922
141purine-containing compound salvage (GO:0043101)2.88200678
142guanosine-containing compound biosynthetic process (GO:1901070)2.87565967
143signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86548178
144intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86548178
145positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86535649
146regulation of protein heterodimerization activity (GO:0043497)2.85035416
147non-recombinational repair (GO:0000726)2.84953604
148double-strand break repair via nonhomologous end joining (GO:0006303)2.84953604
149regulation of vitamin metabolic process (GO:0030656)2.83150519
150ribosome assembly (GO:0042255)2.82949651
151rRNA metabolic process (GO:0016072)2.82696490
152mitotic sister chromatid segregation (GO:0000070)2.82670439
153translesion synthesis (GO:0019985)2.81694349
154polyamine biosynthetic process (GO:0006596)2.81532939
155kinetochore assembly (GO:0051382)2.80697105
156L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.80226361
157signal transduction involved in DNA integrity checkpoint (GO:0072401)2.79589508
158signal transduction involved in DNA damage checkpoint (GO:0072422)2.79589508
159regulation of ligase activity (GO:0051340)2.79552225
160signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.79335726
161signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.79335726
162signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.79335726
163mitotic metaphase plate congression (GO:0007080)2.77766240
164negative regulation of keratinocyte proliferation (GO:0010839)2.77630168
165protein localization to chromosome, centromeric region (GO:0071459)2.77403298
166DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.77103811
167DNA double-strand break processing (GO:0000729)2.76029126
168protein complex localization (GO:0031503)2.75919482
169protein targeting to mitochondrion (GO:0006626)2.73393197
170white fat cell differentiation (GO:0050872)2.73240946
171epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.71557364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.98203127
2E2F7_22180533_ChIP-Seq_HELA_Human6.79038022
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.41358532
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.25670881
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99897388
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.95339325
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.91301373
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86107578
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.77422643
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76413080
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76145911
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.75279995
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.74288959
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.73622032
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71219136
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64334847
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55502033
18XRN2_22483619_ChIP-Seq_HELA_Human2.49489071
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47691794
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46500962
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44330616
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43815657
23MYC_22102868_ChIP-Seq_BL_Human2.35226364
24VDR_23849224_ChIP-Seq_CD4+_Human2.10137590
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08272612
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05792299
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05740936
28CIITA_25753668_ChIP-Seq_RAJI_Human2.02932355
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98209828
30FOXP3_21729870_ChIP-Seq_TREG_Human1.97401496
31GABP_19822575_ChIP-Seq_HepG2_Human1.96791432
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94706097
33DCP1A_22483619_ChIP-Seq_HELA_Human1.94504366
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92605810
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91136533
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.83102634
37TTF2_22483619_ChIP-Seq_HELA_Human1.79568792
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.78344544
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77918254
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75999190
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74813413
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73663839
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69566684
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69004320
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66762075
46ELK1_19687146_ChIP-ChIP_HELA_Human1.64978282
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.64938847
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64436945
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63831948
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61733501
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58759090
52AR_21909140_ChIP-Seq_LNCAP_Human1.57197182
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57038621
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.55663064
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55443858
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49002824
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48704747
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48450881
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47821618
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47285834
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45557180
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.44480757
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42648645
64KDM5A_27292631_Chip-Seq_BREAST_Human1.42004872
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38516271
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38189535
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37251205
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36693626
69TFEB_21752829_ChIP-Seq_HELA_Human1.35139904
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31910347
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27794894
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26613843
73VDR_21846776_ChIP-Seq_THP-1_Human1.23339922
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22943502
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20596629
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.20455420
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16881494
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16822313
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16744468
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15895007
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14277451
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.12611489
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11640809
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11184793
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08668812
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08509025
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08479962
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08433814
89SPI1_23547873_ChIP-Seq_NB4_Human1.04447588
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03917295
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01918938
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01822194
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01498438
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01052892
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98181408
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98053774
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.97996290
98TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96905210
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.96002773
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94836631
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94803777
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94006317
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92661737
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.91729331
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.90263213
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89506498
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89357603
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88173845
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87539711
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86918728
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86448223
112VDR_22108803_ChIP-Seq_LS180_Human0.85895096
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85852409
114CLOCK_20551151_ChIP-Seq_293T_Human0.85664650
115MYC_18940864_ChIP-ChIP_HL60_Human0.82417499
116OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82236722
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79024277
118ZNF274_21170338_ChIP-Seq_K562_Hela0.78822345
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78677171
120SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77894344
121TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75439864
122EOMES_21245162_ChIP-Seq_HESCs_Human0.73470519
123EWS_26573619_Chip-Seq_HEK293_Human0.64087146
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.63616589
125TCF3_18692474_ChIP-Seq_MEFs_Mouse0.61893088
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.61272177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.37765781
2MP0004957_abnormal_blastocyst_morpholog3.96692246
3MP0010094_abnormal_chromosome_stability3.81532674
4MP0005360_urolithiasis3.81462281
5MP0003077_abnormal_cell_cycle3.53104452
6MP0002938_white_spotting3.48086022
7MP0008007_abnormal_cellular_replicative3.36803463
8MP0003111_abnormal_nucleus_morphology3.29612641
9MP0003123_paternal_imprinting3.29392121
10MP0002396_abnormal_hematopoietic_system3.22436293
11MP0008058_abnormal_DNA_repair2.74392675
12MP0010352_gastrointestinal_tract_polyps2.61876003
13MP0008995_early_reproductive_senescence2.59363431
14MP0008057_abnormal_DNA_replication2.58735066
15MP0006054_spinal_hemorrhage2.57325623
16MP0004147_increased_porphyrin_level2.57175358
17MP0005670_abnormal_white_adipose2.56090938
18MP0009697_abnormal_copulation2.49303404
19MP0004808_abnormal_hematopoietic_stem2.44009896
20MP0003941_abnormal_skin_development2.41632148
21MP0001730_embryonic_growth_arrest2.40660366
22MP0001661_extended_life_span2.29772311
23MP0005367_renal/urinary_system_phenotyp2.25020076
24MP0000516_abnormal_urinary_system2.25020076
25MP0008932_abnormal_embryonic_tissue2.17812086
26MP0000350_abnormal_cell_proliferation2.15554241
27MP0005646_abnormal_pituitary_gland2.15357327
28MP0003183_abnormal_peptide_metabolism2.13343765
29MP0000490_abnormal_crypts_of1.94541173
30MP0002736_abnormal_nociception_after1.92412376
31MP0000372_irregular_coat_pigmentation1.92401885
32MP0003718_maternal_effect1.91521584
33MP0001764_abnormal_homeostasis1.88024334
34MP0002139_abnormal_hepatobiliary_system1.84854582
35MP0005332_abnormal_amino_acid1.83925585
36MP0003121_genomic_imprinting1.78034373
37MP0000537_abnormal_urethra_morphology1.75133649
38MP0002138_abnormal_hepatobiliary_system1.71727719
39MP0000013_abnormal_adipose_tissue1.68992720
40MP0001697_abnormal_embryo_size1.67091897
41MP0002080_prenatal_lethality1.65622734
42MP0003122_maternal_imprinting1.64007791
43MP0000647_abnormal_sebaceous_gland1.60768039
44MP0010307_abnormal_tumor_latency1.59631174
45MP0003984_embryonic_growth_retardation1.54113219
46MP0000313_abnormal_cell_death1.53661695
47MP0002019_abnormal_tumor_incidence1.52525439
48MP0002088_abnormal_embryonic_growth/wei1.52511960
49MP0002095_abnormal_skin_pigmentation1.52110558
50MP0001672_abnormal_embryogenesis/_devel1.51608416
51MP0005380_embryogenesis_phenotype1.51608416
52MP0003763_abnormal_thymus_physiology1.50999256
53MP0002398_abnormal_bone_marrow1.45477129
54MP0003705_abnormal_hypodermis_morpholog1.43851596
55MP0000358_abnormal_cell_content/1.43093591
56MP0003786_premature_aging1.39751120
57MP0009333_abnormal_splenocyte_physiolog1.38039669
58MP0010030_abnormal_orbit_morphology1.37511975
59MP0005171_absent_coat_pigmentation1.36499248
60MP0000703_abnormal_thymus_morphology1.36371965
61MP0001835_abnormal_antigen_presentation1.35183657
62MP0004197_abnormal_fetal_growth/weight/1.33528968
63MP0003195_calcinosis1.32372065
64MP0000689_abnormal_spleen_morphology1.31823927
65MP0005220_abnormal_exocrine_pancreas1.31440428
66MP0002254_reproductive_system_inflammat1.29369159
67MP0002722_abnormal_immune_system1.29226022
68MP0008877_abnormal_DNA_methylation1.29153056
69MP0004233_abnormal_muscle_weight1.28915682
70MP0000685_abnormal_immune_system1.28022559
71MP0001348_abnormal_lacrimal_gland1.27197325
72MP0001545_abnormal_hematopoietic_system1.24726691
73MP0005397_hematopoietic_system_phenotyp1.24726691
74MP0002084_abnormal_developmental_patter1.24653689
75MP0008789_abnormal_olfactory_epithelium1.23966621
76MP0005408_hypopigmentation1.23030009
77MP0005075_abnormal_melanosome_morpholog1.22974728
78MP0002102_abnormal_ear_morphology1.22478210
79MP0002085_abnormal_embryonic_tissue1.21581868
80MP0003890_abnormal_embryonic-extraembry1.20264074
81MP0002086_abnormal_extraembryonic_tissu1.18594768
82MP0002429_abnormal_blood_cell1.14958933
83MP0000858_altered_metastatic_potential1.09640111
84MP0006072_abnormal_retinal_apoptosis1.08445443
85MP0005076_abnormal_cell_differentiation1.06309999
86MP0000566_synostosis1.05991211
87MP0006292_abnormal_olfactory_placode1.03807950
88MP0010234_abnormal_vibrissa_follicle1.02377578
89MP0008438_abnormal_cutaneous_collagen1.01252126
90MP0000371_diluted_coat_color1.00509095
91MP0000716_abnormal_immune_system0.99547241
92MP0003221_abnormal_cardiomyocyte_apopto0.98600797
93MP0005384_cellular_phenotype0.97541927
94MP0001800_abnormal_humoral_immune0.96967201
95MP0002132_abnormal_respiratory_system0.96317875
96MP0005023_abnormal_wound_healing0.95960148
97MP0003806_abnormal_nucleotide_metabolis0.95572665
98MP0003943_abnormal_hepatobiliary_system0.95350333
99MP0009672_abnormal_birth_weight0.95281840
100MP0003866_abnormal_defecation0.93244503
101MP0002697_abnormal_eye_size0.92767218
102MP0003119_abnormal_digestive_system0.91812254
103MP0003283_abnormal_digestive_organ0.89809459
104MP0006036_abnormal_mitochondrial_physio0.89402436
105MP0003567_abnormal_fetal_cardiomyocyte0.89229465
106MP0002452_abnormal_antigen_presenting0.89165677
107MP0002295_abnormal_pulmonary_circulatio0.88716009
108MP0005636_abnormal_mineral_homeostasis0.88640745
109MP0008872_abnormal_physiological_respon0.88025647
110MP0004264_abnormal_extraembryonic_tissu0.87950081
111MP0002420_abnormal_adaptive_immunity0.87628276
112MP0005394_taste/olfaction_phenotype0.86944639
113MP0005499_abnormal_olfactory_system0.86944639
114MP0001243_abnormal_dermal_layer0.86853842
115MP0001324_abnormal_eye_pigmentation0.86632729
116MP0003566_abnormal_cell_adhesion0.86567257
117MP0003315_abnormal_perineum_morphology0.85477163
118MP0005085_abnormal_gallbladder_physiolo0.85409348
119MP0001819_abnormal_immune_cell0.84927744
120MP0002089_abnormal_postnatal_growth/wei0.84884714
121MP0001293_anophthalmia0.84584267
122MP0005621_abnormal_cell_physiology0.84380783
123MP0005084_abnormal_gallbladder_morpholo0.84177197
124MP0001849_ear_inflammation0.83155221
125MP0000477_abnormal_intestine_morphology0.82081539
126MP0005253_abnormal_eye_physiology0.81232455
127MP0009053_abnormal_anal_canal0.80829795
128MP0000678_abnormal_parathyroid_gland0.79457644
129MP0004019_abnormal_vitamin_homeostasis0.78206492
130MP0006035_abnormal_mitochondrial_morpho0.78114422
131MP0003942_abnormal_urinary_system0.77436343
132MP0003186_abnormal_redox_activity0.77085544
133MP0004133_heterotaxia0.76313018
134MP0000653_abnormal_sex_gland0.76050610
135MP0001915_intracranial_hemorrhage0.75207188
136MP0001873_stomach_inflammation0.74121270
137MP0002751_abnormal_autonomic_nervous0.73853870
138MP0003937_abnormal_limbs/digits/tail_de0.72646398
139MP0000681_abnormal_thyroid_gland0.72438405
140MP0002111_abnormal_tail_morphology0.70951320
141MP0002166_altered_tumor_susceptibility0.70756713
142MP0005365_abnormal_bile_salt0.69541232
143MP0002090_abnormal_vision0.68936879
144MP0000579_abnormal_nail_morphology0.68647615
145MP0004885_abnormal_endolymph0.68135428
146MP0001119_abnormal_female_reproductive0.67377189
147MP0002282_abnormal_trachea_morphology0.66965382
148MP0002210_abnormal_sex_determination0.66864592
149MP0003724_increased_susceptibility_to0.66764326
150MP0001145_abnormal_male_reproductive0.66574909
151MP0009643_abnormal_urine_homeostasis0.65503506
152MP0005671_abnormal_response_to0.64812454
153MP0000598_abnormal_liver_morphology0.64742325
154MP0001186_pigmentation_phenotype0.64318255
155MP0005197_abnormal_uvea_morphology0.63212455
156MP0002075_abnormal_coat/hair_pigmentati0.62475100
157MP0005319_abnormal_enzyme/_coenzyme0.61852142
158MP0003115_abnormal_respiratory_system0.60514899
159MP0001666_abnormal_nutrient_absorption0.60486701
160MP0005395_other_phenotype0.60310199
161MP0000465_gastrointestinal_hemorrhage0.59916647
162MP0010155_abnormal_intestine_physiology0.59815007
163MP0009278_abnormal_bone_marrow0.58960126
164MP0002723_abnormal_immune_serum0.57876872

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.70935472
2Abnormality of alanine metabolism (HP:0010916)6.70935472
3Hyperalaninemia (HP:0003348)6.70935472
4Abnormal umbilical cord blood vessels (HP:0011403)4.34957935
5Single umbilical artery (HP:0001195)4.34957935
6Abnormality of the fetal cardiovascular system (HP:0010948)4.34957935
7Colon cancer (HP:0003003)4.14293254
8Patchy hypopigmentation of hair (HP:0011365)4.04611847
9Abnormality of serum amino acid levels (HP:0003112)4.02818369
10White forelock (HP:0002211)4.00153021
11Degeneration of anterior horn cells (HP:0002398)3.95181411
12Abnormality of the anterior horn cell (HP:0006802)3.95181411
13Thrombocytosis (HP:0001894)3.90632453
14Aplastic anemia (HP:0001915)3.75222282
15Constricted visual fields (HP:0001133)3.69594083
16Abnormality of cells of the erythroid lineage (HP:0012130)3.66973981
17Reticulocytopenia (HP:0001896)3.53469492
18Ependymoma (HP:0002888)3.52214135
19Abnormal number of erythroid precursors (HP:0012131)3.29474962
20Homocystinuria (HP:0002156)3.27920269
21Abnormality of homocysteine metabolism (HP:0010919)3.27920269
22Congenital sensorineural hearing impairment (HP:0008527)3.25335928
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.19911256
24Abnormality of the umbilical cord (HP:0010881)3.19867325
25Symptomatic seizures (HP:0011145)3.17811854
26Agnosia (HP:0010524)3.11293415
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03211717
28Esophageal varix (HP:0002040)2.99062783
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.96731929
30Nausea (HP:0002018)2.94819704
31Hyperglycinemia (HP:0002154)2.93151037
32Generalized aminoaciduria (HP:0002909)2.91428737
33Abnormality of methionine metabolism (HP:0010901)2.85591850
34Birth length less than 3rd percentile (HP:0003561)2.83574441
35Medulloblastoma (HP:0002885)2.83455154
36Acute encephalopathy (HP:0006846)2.78972486
37Increased serum lactate (HP:0002151)2.68658972
38Selective tooth agenesis (HP:0001592)2.66903794
3911 pairs of ribs (HP:0000878)2.64471096
40Lactic acidosis (HP:0003128)2.62022916
41Chromsome breakage (HP:0040012)2.60432832
42Acute necrotizing encephalopathy (HP:0006965)2.59633071
43Multiple enchondromatosis (HP:0005701)2.59320874
44IgM deficiency (HP:0002850)2.57998951
45Hepatocellular necrosis (HP:0001404)2.55114549
46Adenoma sebaceum (HP:0009720)2.53772353
47Angiofibromas (HP:0010615)2.53772353
48Cutaneous melanoma (HP:0012056)2.53209830
49Increased CSF lactate (HP:0002490)2.51664452
50Myocardial infarction (HP:0001658)2.49140674
51Abnormality of glycolysis (HP:0004366)2.48399647
52Increased serum pyruvate (HP:0003542)2.48399647
53Abnormal lung lobation (HP:0002101)2.46723003
54Abnormalities of placenta or umbilical cord (HP:0001194)2.45828794
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.45729686
56Cerebral edema (HP:0002181)2.43713851
57Amaurosis fugax (HP:0100576)2.43656659
58Neoplasm of the rectum (HP:0100743)2.43468584
59Hepatic necrosis (HP:0002605)2.43121889
60Basal cell carcinoma (HP:0002671)2.42598100
61Megaloblastic anemia (HP:0001889)2.41964072
62Methylmalonic acidemia (HP:0002912)2.41377855
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.41153620
64Mitochondrial inheritance (HP:0001427)2.40122662
65Oral leukoplakia (HP:0002745)2.40025818
66Stenosis of the external auditory canal (HP:0000402)2.38581823
67Rhabdomyosarcoma (HP:0002859)2.36489266
68Abnormality of the calcaneus (HP:0008364)2.36387021
69Hypoplasia of the pons (HP:0012110)2.36371721
70Spastic diplegia (HP:0001264)2.35346131
71Neoplasm of the pancreas (HP:0002894)2.32513899
72Carpal bone hypoplasia (HP:0001498)2.30827622
73Abnormal mitochondria in muscle tissue (HP:0008316)2.30432014
74Atrophy/Degeneration involving motor neurons (HP:0007373)2.29267255
75Glossoptosis (HP:0000162)2.29261967
76Ovarian neoplasm (HP:0100615)2.28256351
77Deviation of the thumb (HP:0009603)2.27631427
78Meckel diverticulum (HP:0002245)2.27396081
79Type I transferrin isoform profile (HP:0003642)2.26565316
80Pallor (HP:0000980)2.25166242
81Anorexia (HP:0002039)2.23760546
82Freckling (HP:0001480)2.22225105
83Neoplasm of the colon (HP:0100273)2.22131603
84Neoplasm of the small intestine (HP:0100833)2.20811014
85Methylmalonic aciduria (HP:0012120)2.20674625
86Spinal muscular atrophy (HP:0007269)2.19982993
87Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19617662
88Cerebral hypomyelination (HP:0006808)2.17666166
89Abnormality of the ileum (HP:0001549)2.14863359
90Intestinal polyposis (HP:0200008)2.13558437
91Spontaneous hematomas (HP:0007420)2.13038091
92Astrocytoma (HP:0009592)2.13030552
93Abnormality of the astrocytes (HP:0100707)2.13030552
94Rough bone trabeculation (HP:0100670)2.11748414
95Hypoglycemic seizures (HP:0002173)2.11298237
96Neoplasm of head and neck (HP:0012288)2.10788208
97Esophageal neoplasm (HP:0100751)2.10788208
98Hyperinsulinemic hypoglycemia (HP:0000825)2.10139966
99Macrocytic anemia (HP:0001972)2.09159973
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08886895
101Intestinal polyp (HP:0005266)2.07653177
102Limb-girdle muscle atrophy (HP:0003797)2.05948342
103Progressive macrocephaly (HP:0004481)2.05906046
104Trismus (HP:0000211)2.05704910
105Protrusio acetabuli (HP:0003179)2.05607420
106Hypoalphalipoproteinemia (HP:0003233)2.04374727
107Conjunctival telangiectasia (HP:0000524)2.03985204
108Abnormality of serine family amino acid metabolism (HP:0010894)2.03617063
109Abnormality of glycine metabolism (HP:0010895)2.03617063
110Poor speech (HP:0002465)2.03355601
111Heterochromia iridis (HP:0001100)2.03227122
112Proximal placement of thumb (HP:0009623)2.02869615
113Cervical subluxation (HP:0003308)2.02489079
114Hypoglycemic coma (HP:0001325)2.02349618
115Intrahepatic cholestasis (HP:0001406)2.02338250
116Abnormality of the preputium (HP:0100587)2.01628393
117Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01627179
118Myelodysplasia (HP:0002863)1.99715918
119Hypolipoproteinemia (HP:0010981)1.97676120
120Cellular immunodeficiency (HP:0005374)1.95905841
121Lethargy (HP:0001254)1.95808809
122Tongue fasciculations (HP:0001308)1.94833161
123Metaphyseal cupping (HP:0003021)1.91510778
124Microretrognathia (HP:0000308)1.90645164
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.89782111
126Conjugated hyperbilirubinemia (HP:0002908)1.89669106
127Metabolic acidosis (HP:0001942)1.88954368
128Arteriovenous malformation (HP:0100026)1.87075371
129Missing ribs (HP:0000921)1.86512179
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86468018
131Abnormal protein N-linked glycosylation (HP:0012347)1.86468018
132Abnormal protein glycosylation (HP:0012346)1.86468018
133Abnormal glycosylation (HP:0012345)1.86468018
134Hand muscle atrophy (HP:0009130)1.86241061
135Increased density of long bones (HP:0006392)1.86071434
136Abnormality of chromosome stability (HP:0003220)1.84736780
137Papilloma (HP:0012740)1.84644375
138Verrucae (HP:0200043)1.84644375
139Increased hepatocellular lipid droplets (HP:0006565)1.83718720
140Proximal tubulopathy (HP:0000114)1.83441929
141Hyperglycemia (HP:0003074)1.82473982
142Oligomenorrhea (HP:0000876)1.81783202
143Large hands (HP:0001176)1.81762062
144Reduced antithrombin III activity (HP:0001976)1.81669765
145Intestinal atresia (HP:0011100)1.81582277
146Maternal diabetes (HP:0009800)1.81095485
147Premature ovarian failure (HP:0008209)1.80503766
148Pancreatic islet-cell hyperplasia (HP:0004510)1.80052691
149Premature graying of hair (HP:0002216)1.79843571
150Bowel diverticulosis (HP:0005222)1.79666597
151Lipid accumulation in hepatocytes (HP:0006561)1.78807513
152Shoulder girdle muscle weakness (HP:0003547)1.78267325
153Abnormality of the pons (HP:0007361)1.78060472
154Abnormality of cells of the lymphoid lineage (HP:0012140)1.77807340
155Patellar aplasia (HP:0006443)1.77744572
156Cortical visual impairment (HP:0100704)1.77642730
157Neoplasm of the adrenal gland (HP:0100631)1.77620422
158Abnormality of pyrimidine metabolism (HP:0004353)1.77618778
159Slender long bone (HP:0003100)1.76681715
160Increased nuchal translucency (HP:0010880)1.76311131
161Postnatal microcephaly (HP:0005484)1.75835685
162Hyperphosphaturia (HP:0003109)1.75649464
163Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74537568
164Cortical dysplasia (HP:0002539)1.74503720
165Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74463581
166Vertebral hypoplasia (HP:0008417)1.74463581
167Exercise intolerance (HP:0003546)1.74307573
168Supernumerary spleens (HP:0009799)1.74305593
169Biconcave vertebral bodies (HP:0004586)1.72812347
170Reduced subcutaneous adipose tissue (HP:0003758)1.72682393
171Abnormality of the vitamin B12 metabolism (HP:0004341)1.70728117
172Muscle fiber atrophy (HP:0100295)1.69856902
173Muscle fibrillation (HP:0010546)1.69366295
174Absent epiphyses (HP:0010577)1.68150703
175Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68150703
176Abnormality of the labia minora (HP:0012880)1.66741685
177Ragged-red muscle fibers (HP:0003200)1.66726107
178CNS hypomyelination (HP:0003429)1.66481450
179Neuroblastoma (HP:0003006)1.66434469
180Primitive neuroectodermal tumor (HP:0030065)1.66434469
181Neuroblastic tumors (HP:0004376)1.66434469
182Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.66434469
183Cellulitis (HP:0100658)1.66208667
184Lymphopenia (HP:0001888)1.65159167
185High anterior hairline (HP:0009890)1.64891496
186Pancytopenia (HP:0001876)1.64316016
187Poikiloderma (HP:0001029)1.64230068
188Aplasia/Hypoplasia of the patella (HP:0006498)1.64132470
189Neoplasm of the peripheral nervous system (HP:0100007)1.63228531
190Posterior subcapsular cataract (HP:0007787)1.62602329
191Biliary tract neoplasm (HP:0100574)1.61497319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.66082395
2TSSK63.65447322
3PBK3.20932956
4BUB13.20169519
5VRK23.04089681
6PASK3.02665917
7TGFBR12.86626336
8NEK12.83039747
9PKN22.75918129
10FLT32.53963083
11TRIM282.50970222
12WEE12.50649593
13CDC72.50321043
14BRSK22.32388526
15RPS6KB22.26335533
16ZAK2.23650159
17EIF2AK12.19918478
18PDK22.08871128
19TRIB32.08098718
20SCYL22.01475746
21NUAK11.92771974
22STK161.87546532
23EIF2AK31.87466500
24MAP4K11.79790392
25CCNB11.79645747
26MAP3K101.76949796
27PAK41.73618659
28BRSK11.70194333
29LRRK21.65519748
30ACVR1B1.65099734
31FGR1.63130776
32CDK91.59869872
33WNK31.57940422
34BCKDK1.57377058
35MAP4K21.54374754
36NEK21.50163332
37NME21.48850933
38DAPK11.46288044
39PLK41.42791498
40MAPKAPK31.38892107
41MKNK11.37396734
42BCR1.37008680
43ATR1.33669725
44TESK21.32567727
45TAF11.31765695
46NME11.23950289
47TESK11.23466117
48ERN11.23038842
49PLK31.22480172
50MAP3K121.21815214
51KIT1.21582602
52EPHB21.19676454
53MKNK21.17756050
54PLK11.17258691
55TLK11.16642933
56PIM21.16240623
57CDK81.10695205
58STK101.04053784
59SRPK11.03656113
60PLK21.03571041
61CSF1R1.02790166
62RPS6KA41.02724257
63ILK1.02299642
64CDK71.00146908
65VRK10.99464841
66INSRR0.98794816
67AURKB0.98093019
68CSNK1G30.95656578
69PDK40.95511471
70PDK30.95511471
71ZAP700.90484131
72CDK190.90482716
73BTK0.90282103
74CSNK1G10.89720190
75DYRK20.88920693
76GRK60.85982271
77EIF2AK20.83407566
78ERBB40.82426221
79MAP2K30.77669705
80MAP3K80.77217864
81CDK40.75051631
82TTK0.74933598
83AURKA0.73907049
84TIE10.72588223
85CHEK10.69110371
86BMPR1B0.68325762
87TNIK0.67492001
88CSNK1A10.62743516
89CSNK1A1L0.60700114
90SIK30.59634894
91MYLK0.59081644
92PIM10.58813902
93CSNK1G20.58595691
94PRKCI0.58508784
95JAK30.58159026
96TTN0.56804087
97CSNK2A20.54005782
98MATK0.53860316
99ERBB30.52734102
100ALK0.51396602
101STK240.50672916
102FGFR10.50264998
103PAK10.49949126
104LIMK10.49769931
105MST40.49094734
106STK40.48975614
107MAPKAPK50.48110800
108CDK20.45612425
109PAK20.44981356
110RPS6KB10.43775237
111CSNK2A10.43340567
112RPS6KA60.42369965
113RPS6KC10.41008721
114RPS6KL10.41008721
115ATM0.40815947
116MAPKAPK20.40394115
117BRD40.40019814
118RAF10.39967114
119SYK0.39504520
120MAP2K10.38499177
121CHEK20.38268754
122AKT20.38146968
123TGFBR20.37300504
124CAMKK20.36421470
125CLK10.36114895
126STK30.35463902
127TYK20.34885093
128DAPK30.33792181
129BLK0.32855835
130LMTK20.32465310
131MINK10.31298308
132MAP3K30.30681202
133CHUK0.29856782
134GRK10.29501727
135SMG10.29122227
136KDR0.27891670
137ABL20.27737567
138KSR10.27383806
139FGFR20.27365043
140CDK10.27279075
141EPHA20.27001659
142EGFR0.26995310
143OXSR10.26742885
144NEK60.26206567
145CAMK2D0.25935865
146PRKCE0.24851963
147SGK2230.21938981

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.33073173
2Mismatch repair_Homo sapiens_hsa034303.79497315
3Ribosome_Homo sapiens_hsa030103.62626851
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.58705188
5Proteasome_Homo sapiens_hsa030503.55313490
6Spliceosome_Homo sapiens_hsa030403.09693881
7Base excision repair_Homo sapiens_hsa034102.96722980
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.95401233
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87413332
10RNA transport_Homo sapiens_hsa030132.87028299
11One carbon pool by folate_Homo sapiens_hsa006702.74583449
12Sulfur metabolism_Homo sapiens_hsa009202.51515609
13RNA polymerase_Homo sapiens_hsa030202.27395927
14Nucleotide excision repair_Homo sapiens_hsa034202.25408089
15Non-homologous end-joining_Homo sapiens_hsa034502.20792655
16Cell cycle_Homo sapiens_hsa041102.20269042
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.10587527
18Pyrimidine metabolism_Homo sapiens_hsa002402.00619811
19Oxidative phosphorylation_Homo sapiens_hsa001901.92829942
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86282044
21Caffeine metabolism_Homo sapiens_hsa002321.83947756
22Arginine biosynthesis_Homo sapiens_hsa002201.81521672
23Propanoate metabolism_Homo sapiens_hsa006401.71998614
24Fatty acid elongation_Homo sapiens_hsa000621.65703208
25Biosynthesis of amino acids_Homo sapiens_hsa012301.63142055
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62795829
27Homologous recombination_Homo sapiens_hsa034401.62712736
28mRNA surveillance pathway_Homo sapiens_hsa030151.53162907
29RNA degradation_Homo sapiens_hsa030181.52827053
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49890532
31Collecting duct acid secretion_Homo sapiens_hsa049661.46379341
32Antigen processing and presentation_Homo sapiens_hsa046121.40991190
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40207117
34Carbon metabolism_Homo sapiens_hsa012001.30465105
35N-Glycan biosynthesis_Homo sapiens_hsa005101.29238723
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28336008
37Epstein-Barr virus infection_Homo sapiens_hsa051691.28317603
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24474379
39Legionellosis_Homo sapiens_hsa051341.21920879
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20504926
41Selenocompound metabolism_Homo sapiens_hsa004501.14870333
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.14326346
43Steroid biosynthesis_Homo sapiens_hsa001001.13212170
44Vitamin digestion and absorption_Homo sapiens_hsa049771.11363578
45Protein export_Homo sapiens_hsa030601.07122245
46Viral carcinogenesis_Homo sapiens_hsa052031.03070057
47p53 signaling pathway_Homo sapiens_hsa041151.00003035
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.98492279
49Arginine and proline metabolism_Homo sapiens_hsa003300.97594500
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96578702
51Peroxisome_Homo sapiens_hsa041460.95149426
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95147768
53Thyroid cancer_Homo sapiens_hsa052160.92471486
54Purine metabolism_Homo sapiens_hsa002300.91217990
55Pentose phosphate pathway_Homo sapiens_hsa000300.89804294
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89747270
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.86161355
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85483228
59Pyruvate metabolism_Homo sapiens_hsa006200.85241383
60Shigellosis_Homo sapiens_hsa051310.84882673
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.83836547
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83047686
63Vitamin B6 metabolism_Homo sapiens_hsa007500.82751482
64Vibrio cholerae infection_Homo sapiens_hsa051100.82692558
65Metabolic pathways_Homo sapiens_hsa011000.82165045
66Butanoate metabolism_Homo sapiens_hsa006500.81705424
67Oocyte meiosis_Homo sapiens_hsa041140.80687519
68Alzheimers disease_Homo sapiens_hsa050100.76710901
69Fructose and mannose metabolism_Homo sapiens_hsa000510.76643408
70HTLV-I infection_Homo sapiens_hsa051660.76015911
71Fanconi anemia pathway_Homo sapiens_hsa034600.75530150
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.73621743
73Systemic lupus erythematosus_Homo sapiens_hsa053220.72266648
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71672022
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71408485
76Primary immunodeficiency_Homo sapiens_hsa053400.70696390
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70329797
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68511415
79Colorectal cancer_Homo sapiens_hsa052100.66145084
80Galactose metabolism_Homo sapiens_hsa000520.65044343
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64912957
82Apoptosis_Homo sapiens_hsa042100.64013395
83Herpes simplex infection_Homo sapiens_hsa051680.63745723
84Fat digestion and absorption_Homo sapiens_hsa049750.63449302
85Fatty acid metabolism_Homo sapiens_hsa012120.63261841
86Tryptophan metabolism_Homo sapiens_hsa003800.63086079
87Retinol metabolism_Homo sapiens_hsa008300.61995507
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61413049
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58118320
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56389969
91Chronic myeloid leukemia_Homo sapiens_hsa052200.56005083
92Basal transcription factors_Homo sapiens_hsa030220.55133494
93Fatty acid degradation_Homo sapiens_hsa000710.54927597
94Bladder cancer_Homo sapiens_hsa052190.51418958
95Regulation of autophagy_Homo sapiens_hsa041400.50520095
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50032838
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47235090
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46826334
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44575426
100HIF-1 signaling pathway_Homo sapiens_hsa040660.44112497
101Small cell lung cancer_Homo sapiens_hsa052220.43909745
102Chemical carcinogenesis_Homo sapiens_hsa052040.42400831
103beta-Alanine metabolism_Homo sapiens_hsa004100.41012531
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40913409
105Parkinsons disease_Homo sapiens_hsa050120.39721216
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39464291
107Non-small cell lung cancer_Homo sapiens_hsa052230.39339682
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.39200873
109Folate biosynthesis_Homo sapiens_hsa007900.39033210
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39003384
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38282066
112Hepatitis B_Homo sapiens_hsa051610.36723247
113Measles_Homo sapiens_hsa051620.35957101
114B cell receptor signaling pathway_Homo sapiens_hsa046620.35263498
115Influenza A_Homo sapiens_hsa051640.35150113
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.33985220
117Alcoholism_Homo sapiens_hsa050340.33614945
118Acute myeloid leukemia_Homo sapiens_hsa052210.33589534
119Rheumatoid arthritis_Homo sapiens_hsa053230.33553383
120MicroRNAs in cancer_Homo sapiens_hsa052060.33119031
121Renin-angiotensin system_Homo sapiens_hsa046140.30999892
122Phenylalanine metabolism_Homo sapiens_hsa003600.30682802
123Ether lipid metabolism_Homo sapiens_hsa005650.30096468
124Starch and sucrose metabolism_Homo sapiens_hsa005000.28217143
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27735922
126Sulfur relay system_Homo sapiens_hsa041220.27358912
127mTOR signaling pathway_Homo sapiens_hsa041500.25514395
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24659687
129Tyrosine metabolism_Homo sapiens_hsa003500.23546766
130Pancreatic cancer_Homo sapiens_hsa052120.23057027
131Phagosome_Homo sapiens_hsa041450.21572784
132Type I diabetes mellitus_Homo sapiens_hsa049400.21253887
133Viral myocarditis_Homo sapiens_hsa054160.20564155
134Notch signaling pathway_Homo sapiens_hsa043300.19628361
135Hippo signaling pathway_Homo sapiens_hsa043900.18546970
136Other glycan degradation_Homo sapiens_hsa005110.17076911
137Endometrial cancer_Homo sapiens_hsa052130.16057464
138Platelet activation_Homo sapiens_hsa046110.15418932
139Huntingtons disease_Homo sapiens_hsa050160.13782374
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.12749630
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10961423
142Glutathione metabolism_Homo sapiens_hsa004800.10867595
143Toxoplasmosis_Homo sapiens_hsa051450.10625154
144Leishmaniasis_Homo sapiens_hsa051400.10241950
145Proteoglycans in cancer_Homo sapiens_hsa052050.08792119
146Pathways in cancer_Homo sapiens_hsa052000.05994295
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05187677

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