RTEL1-TNFRSF6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring RTEL1 (regulator of telomere elongation helicase 1) and TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy) genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)6.32170869
2mannose metabolic process (GO:0006013)6.14614310
3positive regulation of protein kinase C signaling (GO:0090037)5.88709765
4semaphorin-plexin signaling pathway (GO:0071526)5.69388196
5adenosine receptor signaling pathway (GO:0001973)5.68216923
6cellular response to ATP (GO:0071318)5.45679549
7peptidyl-glutamic acid carboxylation (GO:0017187)5.36672479
8protein carboxylation (GO:0018214)5.36672479
9regulation of skeletal muscle contraction (GO:0014819)5.31998137
10negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.80978328
11regulation of synapse structural plasticity (GO:0051823)4.67243975
12negative regulation of cell aging (GO:0090344)4.61392275
13regulation of cytokine production involved in inflammatory response (GO:1900015)4.50535539
14positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.49206000
15DNA strand renaturation (GO:0000733)4.41560175
16regulation of ARF GTPase activity (GO:0032312)4.23889283
17UV protection (GO:0009650)4.18170413
18lens fiber cell differentiation (GO:0070306)4.00074544
19G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.87863473
20endocytic recycling (GO:0032456)3.68250401
21endothelial cell chemotaxis (GO:0035767)3.67347784
22atrioventricular valve morphogenesis (GO:0003181)3.65701219
23negative regulation of erythrocyte differentiation (GO:0045647)3.65372885
24sensory perception of taste (GO:0050909)3.60618082
25meiotic chromosome segregation (GO:0045132)3.56349161
26regulation of hydrogen peroxide metabolic process (GO:0010310)3.47698776
27phosphatidylglycerol biosynthetic process (GO:0006655)3.39084301
28negative regulation of cell size (GO:0045792)3.38070210
29adenine nucleotide transport (GO:0051503)3.36810373
30urinary tract smooth muscle contraction (GO:0014848)3.31406832
31purinergic nucleotide receptor signaling pathway (GO:0035590)3.29187269
32response to ATP (GO:0033198)3.27251522
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.26425682
34negative regulation of interleukin-8 production (GO:0032717)3.22223351
35sex determination (GO:0007530)3.18548384
36transepithelial transport (GO:0070633)3.17012363
37planar cell polarity pathway involved in neural tube closure (GO:0090179)3.17011985
38cellular response to virus (GO:0098586)3.10336080
39phosphate ion transmembrane transport (GO:0035435)3.07355637
40cell-substrate adherens junction assembly (GO:0007045)3.05829178
41focal adhesion assembly (GO:0048041)3.05829178
42G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.04421166
43proline biosynthetic process (GO:0006561)3.02302067
44purine ribonucleotide transport (GO:0015868)3.01852191
45activation of Rac GTPase activity (GO:0032863)3.00963217
46mitotic cell cycle arrest (GO:0071850)2.98953740
47negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.96462206
48protein retention in ER lumen (GO:0006621)2.95373994
49negative regulation of fatty acid transport (GO:2000192)2.94514010
50histone H4 deacetylation (GO:0070933)2.94196238
51melanin biosynthetic process (GO:0042438)2.92742970
52cell-cell junction maintenance (GO:0045217)2.91469280
53adherens junction assembly (GO:0034333)2.90260737
54basement membrane organization (GO:0071711)2.89636764
55regulation of type I interferon-mediated signaling pathway (GO:0060338)2.89219578
56positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.88726736
57purinergic receptor signaling pathway (GO:0035587)2.88228115
58positive regulation of synapse maturation (GO:0090129)2.87496959
59regulation of cholesterol biosynthetic process (GO:0045540)2.81035404
60regulation of cholesterol homeostasis (GO:2000188)2.80469833
61positive regulation of histone deacetylation (GO:0031065)2.80040000
62positive regulation of heat generation (GO:0031652)2.79917262
63regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.77297422
64actin filament bundle assembly (GO:0051017)2.77222793
65actin filament bundle organization (GO:0061572)2.77222793
66regulation of protein kinase C signaling (GO:0090036)2.77011921
67positive regulation of CREB transcription factor activity (GO:0032793)2.76288267
68modulation by virus of host process (GO:0019054)2.76124753
69purine nucleotide transport (GO:0015865)2.76005605
70proline metabolic process (GO:0006560)2.75144218
71activation of JUN kinase activity (GO:0007257)2.75136687
72melanin metabolic process (GO:0006582)2.73958191
73cell migration in hindbrain (GO:0021535)2.73903215
74regulation of fatty acid beta-oxidation (GO:0031998)2.71352529
75histone phosphorylation (GO:0016572)2.67519291
76regulation of cholesterol metabolic process (GO:0090181)2.67414160
77cell-substrate junction assembly (GO:0007044)2.67283737
78cardiolipin metabolic process (GO:0032048)2.65800111
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60313089
80regulation of histone H3-K27 methylation (GO:0061085)2.59133245
81regulation of phospholipid biosynthetic process (GO:0071071)2.57184739
82negative regulation of tumor necrosis factor production (GO:0032720)2.55868022
83modulation by symbiont of host cellular process (GO:0044068)2.55391280
84histone H3 deacetylation (GO:0070932)2.53759847
85Rho protein signal transduction (GO:0007266)2.52408358
86cell volume homeostasis (GO:0006884)2.51247263
87nucleotide-sugar biosynthetic process (GO:0009226)2.50973377
88sphingomyelin metabolic process (GO:0006684)2.50270409
89phospholipid scrambling (GO:0017121)2.49933822
90negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.48371929
91apoptotic process involved in morphogenesis (GO:0060561)2.46103577
92snRNA metabolic process (GO:0016073)2.45727346
93type B pancreatic cell proliferation (GO:0044342)2.43992604
94insulin-like growth factor receptor signaling pathway (GO:0048009)2.42337768
95granulocyte differentiation (GO:0030851)2.42305244
96negative regulation of granulocyte differentiation (GO:0030853)2.41832511
97trivalent inorganic anion homeostasis (GO:0072506)2.40168036
98phosphate ion homeostasis (GO:0055062)2.40168036
99response to muramyl dipeptide (GO:0032495)2.39594566
100CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.34441680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.76020491
2LXR_22292898_ChIP-Seq_THP-1_Human3.30882427
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.00577195
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.94442515
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.90148148
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.82815392
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.60323315
8P68_20966046_ChIP-Seq_HELA_Human2.59383245
9RACK7_27058665_Chip-Seq_MCF-7_Human2.51401725
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.44327844
11MYC_22102868_ChIP-Seq_BL_Human2.34153853
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.32365551
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.30020294
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.28767645
15KDM2B_26808549_Chip-Seq_DND41_Human2.21542564
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.14535106
17TCF7_22412390_ChIP-Seq_EML_Mouse2.12822974
18MAF_26560356_Chip-Seq_TH2_Human2.02457757
19CTCF_27219007_Chip-Seq_ERYTHROID_Human2.00549170
20SMC4_20622854_ChIP-Seq_HELA_Human1.94175243
21VDR_24763502_ChIP-Seq_THP-1_Human1.94036651
22TET1_21451524_ChIP-Seq_MESCs_Mouse1.90507921
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.88443685
24BCOR_27268052_Chip-Seq_Bcells_Human1.87504031
25CTCF_27219007_Chip-Seq_Bcells_Human1.86081758
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.84689683
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.80902290
28MAF_26560356_Chip-Seq_TH1_Human1.79628624
29BCL6_27268052_Chip-Seq_Bcells_Human1.78290450
30KDM2B_26808549_Chip-Seq_K562_Human1.77978167
31SA1_27219007_Chip-Seq_ERYTHROID_Human1.77514563
32EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.77160199
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76619055
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72550027
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.70457772
36CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.69496295
37E2F1_20622854_ChIP-Seq_HELA_Human1.68350900
38MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.67171167
39CREB1_26743006_Chip-Seq_LNCaP_Human1.65614353
40RARB_24833708_ChIP-Seq_LIVER_Mouse1.59869460
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59060950
42SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.58288139
43PHF8_20622854_ChIP-Seq_HELA_Human1.57585324
44TP53_22127205_ChIP-Seq_IMR90_Human1.55891395
45SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54999531
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54166663
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53755618
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.53267810
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53181975
50UTX_26944678_Chip-Seq_JUKART_Human1.49149832
51RARA_24833708_ChIP-Seq_LIVER_Mouse1.48824012
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.47929833
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46864195
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45556146
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45268073
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.45241563
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40136733
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35573272
59CTCF_21964334_Chip-Seq_Bcells_Human1.34485433
60RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30277495
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30053857
62NCOR1_26117541_ChIP-Seq_K562_Human1.27523783
63ZNF263_19887448_ChIP-Seq_K562_Human1.27464767
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27213122
65ATF3_27146783_Chip-Seq_COLON_Human1.26835428
66CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26009059
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25857875
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25782147
69FOXP1_21924763_ChIP-Seq_HESCs_Human1.24368272
70XRN2_22483619_ChIP-Seq_HELA_Human1.24154198
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20742014
72SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20062873
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19936466
74TP63_22573176_ChIP-Seq_HFKS_Human1.19383359
75CTCF_20526341_ChIP-Seq_ESCs_Human1.17491376
76SA1_27219007_Chip-Seq_Bcells_Human1.17400812
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16873827
78TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16480385
79ETS1_21867929_ChIP-Seq_TH2_Mouse1.16180108
80PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15651842
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15140817
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.14558184
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13868168
84JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.13650381
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.12996293
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12613317
87DROSHA_22980978_ChIP-Seq_HELA_Human1.10320851
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.10164879
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08651411
90SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07210595
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06598087
92FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06550185
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05207559
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.04587737
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.03797846
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03676097
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03544095
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.02089994
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01615863
100OCT4_19829295_ChIP-Seq_ESCs_Human1.01098337

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation5.34302197
2MP0005409_darkened_coat_color4.35562014
3MP0005174_abnormal_tail_pigmentation4.07689415
4MP0003705_abnormal_hypodermis_morpholog3.95325459
5MP0001986_abnormal_taste_sensitivity3.91374840
6MP0005423_abnormal_somatic_nervous3.73823301
7MP0003136_yellow_coat_color3.63998685
8MP0000751_myopathy3.18349568
9MP0005076_abnormal_cell_differentiation2.98165178
10MP0005058_abnormal_lysosome_morphology2.81561287
11MP0003453_abnormal_keratinocyte_physiol2.54065456
12MP0005083_abnormal_biliary_tract2.42540395
13MP0003172_abnormal_lysosome_physiology2.40508521
14MP0004381_abnormal_hair_follicle2.39340646
15MP0001188_hyperpigmentation2.34800162
16MP0000013_abnormal_adipose_tissue2.08315036
17MP0001958_emphysema1.99909867
18MP0000003_abnormal_adipose_tissue1.95552885
19MP0001348_abnormal_lacrimal_gland1.89869617
20MP0001502_abnormal_circadian_rhythm1.88929217
21MP0000015_abnormal_ear_pigmentation1.78158406
22MP0001849_ear_inflammation1.72751424
23MP0009278_abnormal_bone_marrow1.70241108
24MP0001661_extended_life_span1.68888426
25MP0003091_abnormal_cell_migration1.65956827
26MP0003279_aneurysm1.64705711
27MP0002933_joint_inflammation1.63526068
28MP0005330_cardiomyopathy1.62320432
29MP0008875_abnormal_xenobiotic_pharmacok1.55392711
30MP0001756_abnormal_urination1.51643177
31MP0000678_abnormal_parathyroid_gland1.47477675
32MP0009384_cardiac_valve_regurgitation1.46367854
33MP0004130_abnormal_muscle_cell1.42864533
34MP0003303_peritoneal_inflammation1.42501729
35MP0009840_abnormal_foam_cell1.38538572
36MP0008260_abnormal_autophagy1.37837019
37MP0000750_abnormal_muscle_regeneration1.37076036
38MP0005257_abnormal_intraocular_pressure1.33983846
39MP0005023_abnormal_wound_healing1.33221666
40MP0002249_abnormal_larynx_morphology1.28693501
41MP0005375_adipose_tissue_phenotype1.27721677
42MP0000747_muscle_weakness1.27660221
43MP0004185_abnormal_adipocyte_glucose1.27341795
44MP0005451_abnormal_body_composition1.26343561
45MP0001968_abnormal_touch/_nociception1.24975137
46MP0005501_abnormal_skin_physiology1.24781034
47MP0000538_abnormal_urinary_bladder1.23152838
48MP0001873_stomach_inflammation1.22762285
49MP0004858_abnormal_nervous_system1.18946227
50MP0003436_decreased_susceptibility_to1.11052709
51MP0000767_abnormal_smooth_muscle1.08997497
52MP0005666_abnormal_adipose_tissue1.07303805
53MP0004947_skin_inflammation1.06234009
54MP0003045_fibrosis1.04985759
55MP0002060_abnormal_skin_morphology1.01927130
56MP0001765_abnormal_ion_homeostasis0.99399538
57MP0001664_abnormal_digestion0.98256738
58MP0009931_abnormal_skin_appearance0.98057695
59MP0002089_abnormal_postnatal_growth/wei0.88433906
60MP0002254_reproductive_system_inflammat0.87873251
61MP0003111_abnormal_nucleus_morphology0.86973655
62MP0000858_altered_metastatic_potential0.84344534
63MP0008438_abnormal_cutaneous_collagen0.82240738
64MP0005360_urolithiasis0.82150973
65MP0004043_abnormal_pH_regulation0.80907646
66MP0004087_abnormal_muscle_fiber0.78029937
67MP0003448_altered_tumor_morphology0.77805244
68MP0000367_abnormal_coat/_hair0.75537850
69MP0003329_amyloid_beta_deposits0.75252134
70MP0003566_abnormal_cell_adhesion0.74705658
71MP0005365_abnormal_bile_salt0.73788713
72MP0000470_abnormal_stomach_morphology0.72001234
73MP0002896_abnormal_bone_mineralization0.71090174
74MP0000733_abnormal_muscle_development0.69694826
75MP0000759_abnormal_skeletal_muscle0.68000836
76MP0005584_abnormal_enzyme/coenzyme_acti0.67713474
77MP0002998_abnormal_bone_remodeling0.66679863
78MP0002796_impaired_skin_barrier0.66528516
79MP0010771_integument_phenotype0.65246603
80MP0004510_myositis0.64566771
81MP0003879_abnormal_hair_cell0.64467477
82MP0005621_abnormal_cell_physiology0.64059970
83MP0002075_abnormal_coat/hair_pigmentati0.60361585
84MP0009643_abnormal_urine_homeostasis0.56583765
85MP0008874_decreased_physiological_sensi0.55999796
86MP0010155_abnormal_intestine_physiology0.55351339
87MP0003283_abnormal_digestive_organ0.54892548
88MP0001216_abnormal_epidermal_layer0.53172443
89MP0005332_abnormal_amino_acid0.52089278
90MP0006138_congestive_heart_failure0.51029885
91MP0002019_abnormal_tumor_incidence0.49329098
92MP0004197_abnormal_fetal_growth/weight/0.48933238
93MP0002136_abnormal_kidney_physiology0.47989359
94MP0002877_abnormal_melanocyte_morpholog0.47987580
95MP0002118_abnormal_lipid_homeostasis0.47277150
96MP0004019_abnormal_vitamin_homeostasis0.46464791
97MP0003115_abnormal_respiratory_system0.44199010
98MP0005377_hearing/vestibular/ear_phenot0.42529249
99MP0003878_abnormal_ear_physiology0.42529249
100MP0002932_abnormal_joint_morphology0.42478669

Predicted human phenotypes

RankGene SetZ-score
1Thin bony cortex (HP:0002753)5.88607172
2Testicular atrophy (HP:0000029)5.46035478
3Ulnar bowing (HP:0003031)5.01741388
4Annular pancreas (HP:0001734)4.80731404
5Hemorrhage of the eye (HP:0011885)4.60976264
6Rib fusion (HP:0000902)4.51782715
7Turricephaly (HP:0000262)4.05116205
8Intestinal fistula (HP:0100819)3.84133909
9Poikiloderma (HP:0001029)3.73677433
10Mesangial abnormality (HP:0001966)3.62536015
11Facial hemangioma (HP:0000329)3.54490692
12Joint stiffness (HP:0001387)3.51014236
13Akinesia (HP:0002304)3.50316038
14Vaginal fistula (HP:0004320)3.48958106
15Joint hemorrhage (HP:0005261)3.48650983
16Rectal fistula (HP:0100590)3.42823604
17Rectovaginal fistula (HP:0000143)3.42823604
18Dyschromatopsia (HP:0007641)3.25591816
19Cervical subluxation (HP:0003308)3.18168829
20Abnormality of the intrinsic pathway (HP:0010989)3.15672829
21Broad face (HP:0000283)3.09825092
22Facial diplegia (HP:0001349)3.09049410
23Coronal craniosynostosis (HP:0004440)3.07826239
24Popliteal pterygium (HP:0009756)2.97302588
25Obstructive sleep apnea (HP:0002870)2.90334843
26Anteriorly placed anus (HP:0001545)2.87003507
27Delayed epiphyseal ossification (HP:0002663)2.82680977
28Squamous cell carcinoma (HP:0002860)2.80301333
29Thin ribs (HP:0000883)2.75744568
30Attenuation of retinal blood vessels (HP:0007843)2.71922789
31Aplasia of the musculature (HP:0100854)2.71320094
32Bowing of the arm (HP:0006488)2.69022890
33Bowed forearm bones (HP:0003956)2.69022890
34Prolonged partial thromboplastin time (HP:0003645)2.66840716
35Atrioventricular block (HP:0001678)2.66348834
36Abnormality of polysaccharide metabolism (HP:0011012)2.64507395
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64507395
38Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64507395
39Urinary glycosaminoglycan excretion (HP:0003541)2.62459815
40Mucopolysacchariduria (HP:0008155)2.62459815
41Short chin (HP:0000331)2.62311130
42Cerebral aneurysm (HP:0004944)2.58611581
43Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.56865239
44Myopathic facies (HP:0002058)2.48177258
45Protrusio acetabuli (HP:0003179)2.38987366
46Zonular cataract (HP:0010920)2.38885229
47Fetal akinesia sequence (HP:0001989)2.37876270
48Capillary hemangiomas (HP:0005306)2.33548658
49Easy fatigability (HP:0003388)2.31389332
50Abnormality of the costochondral junction (HP:0000919)2.27560764
51Enlarged epiphyses (HP:0010580)2.26367100
52J-shaped sella turcica (HP:0002680)2.25666700
53Hyperacusis (HP:0010780)2.25468602
54Upper limb amyotrophy (HP:0009129)2.21926905
55Distal upper limb amyotrophy (HP:0007149)2.21926905
56Myotonia (HP:0002486)2.21243033
57Patellar aplasia (HP:0006443)2.20662093
58Choroideremia (HP:0001139)2.11223319
59Abnormal atrioventricular conduction (HP:0005150)2.11067387
60Male infertility (HP:0003251)2.06923927
61Neonatal onset (HP:0003623)2.05039929
62Abnormality of the fingertips (HP:0001211)2.03278715
63Mask-like facies (HP:0000298)2.01311150
64Dysostosis multiplex (HP:0000943)2.01276954
65Aplasia/Hypoplasia of the patella (HP:0006498)2.01236364
66Widely patent fontanelles and sutures (HP:0004492)2.01148276
67Distal lower limb amyotrophy (HP:0008944)2.00730834
68Stridor (HP:0010307)1.98528957
69Dislocated radial head (HP:0003083)1.98517163
70Flat occiput (HP:0005469)1.98269723
71Shallow orbits (HP:0000586)1.97707379
72Rectal prolapse (HP:0002035)1.97614874
73Hypophosphatemic rickets (HP:0004912)1.93841592
74Pterygium (HP:0001059)1.93457904
75Heart block (HP:0012722)1.93282023
76Narrow nasal bridge (HP:0000446)1.92608642
77Congenital hip dislocation (HP:0001374)1.90223425
78Biconcave vertebral bodies (HP:0004586)1.89726501
79Choanal stenosis (HP:0000452)1.88133669
80Malnutrition (HP:0004395)1.87176459
81Abnormality of the common coagulation pathway (HP:0010990)1.86725678
82Short humerus (HP:0005792)1.86720014
83Premature graying of hair (HP:0002216)1.86639235
84Neonatal respiratory distress (HP:0002643)1.86400772
85Cheilitis (HP:0100825)1.86041292
86Abnormality of the radial head (HP:0003995)1.85461945
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83046307
88Malignant hyperthermia (HP:0002047)1.79626714
89Nuclear cataract (HP:0100018)1.76340104
90Abnormal albumin level (HP:0012116)1.75980326
91Hypoalbuminemia (HP:0003073)1.75980326
92Congenital stationary night blindness (HP:0007642)1.74180638
93Bony spicule pigmentary retinopathy (HP:0007737)1.74128497
94Emphysema (HP:0002097)1.73524208
95Basal cell carcinoma (HP:0002671)1.66766883
96Tibial bowing (HP:0002982)1.66332957
97Pointed chin (HP:0000307)1.65824554
98Spina bifida occulta (HP:0003298)1.65435661
99Asymmetric septal hypertrophy (HP:0001670)1.64989531
100Lymphangioma (HP:0100764)1.64302385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.08722749
2TRIB34.84492518
3SIK13.44016104
4MST1R2.92425360
5ERN12.87655263
6ICK2.37636417
7RIPK12.20896900
8EPHA22.17244460
9WNK42.15440719
10PRPF4B2.10376425
11BLK1.92019390
12MAP2K31.87867823
13SIK21.84626673
14PKN21.82895477
15MUSK1.77582374
16SMG11.73846499
17FGFR41.72204743
18CDK121.70454036
19EEF2K1.68667702
20TTN1.54572928
21BMX1.48923079
22PRKD21.46621359
23MARK21.44211221
24CDC42BPA1.38707489
25ZAP701.37316850
26MAP2K61.35607564
27IRAK31.33525652
28PDGFRA1.28334888
29GRK61.26620797
30PDPK11.25141473
31MET1.22932681
32MAP4K11.22815738
33RPS6KA21.21502310
34MTOR1.17644369
35TBK11.16291131
36TNK21.15406107
37MAP3K71.09330436
38TESK21.07776275
39TLK11.07460208
40EPHB11.06984618
41PTK61.05369566
42WNK11.00653069
43RPS6KC10.95311393
44RPS6KL10.95311393
45MAPK110.88382972
46MAP3K130.87959433
47PTK20.85855078
48RPS6KA60.84822703
49CDK40.84188865
50MAP3K60.82436980
51TAOK20.77364170
52IRAK20.77044750
53DDR20.76887967
54HIPK20.76863709
55MAP3K110.75866532
56MAPK120.74329623
57CAMKK10.72378020
58TYRO30.70349154
59LMTK20.68062127
60MAP3K30.65318219
61PRKD10.65118835
62PRKD30.64406797
63PAK40.62912876
64DYRK1B0.62311979
65CSK0.61213178
66MELK0.57707418
67STK380.56664138
68MAPK80.54243818
69MAP3K10.53456175
70NME20.52436751
71PDGFRB0.52299508
72SIK30.49523642
73CDK60.48503656
74CDK150.48347932
75ERBB20.47658599
76DAPK20.46627856
77NEK20.46349685
78CDK11A0.45523468
79PDK10.44953972
80RET0.43523662
81CHUK0.43452360
82MAP3K100.43129259
83MAP3K140.42292582
84TAOK10.41401922
85PRKAA10.40465195
86CDK180.39962008
87NTRK10.39802315
88TYK20.39086279
89MAPK70.37755084
90PAK10.37369535
91PRKCH0.35206453
92RIPK40.33331889
93IKBKE0.32657273
94FGFR30.31652635
95MAPKAPK30.30347583
96MAPK30.28616657
97RPS6KA10.28440580
98MAP2K20.27899882
99JAK30.27313493
100IKBKB0.27055001

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.32913019
2Sulfur relay system_Homo sapiens_hsa041223.53172289
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.45227645
4Other glycan degradation_Homo sapiens_hsa005113.31270566
5Fructose and mannose metabolism_Homo sapiens_hsa000512.66963147
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.50308469
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.14502225
8Notch signaling pathway_Homo sapiens_hsa043302.03408932
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.00397767
10VEGF signaling pathway_Homo sapiens_hsa043701.65984818
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58992535
12mTOR signaling pathway_Homo sapiens_hsa041501.54832480
13Sphingolipid metabolism_Homo sapiens_hsa006001.40696387
14Lysine degradation_Homo sapiens_hsa003101.32557729
15Inositol phosphate metabolism_Homo sapiens_hsa005621.28898060
16Acute myeloid leukemia_Homo sapiens_hsa052211.23170613
17Bladder cancer_Homo sapiens_hsa052191.22772813
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.17765860
19Lysosome_Homo sapiens_hsa041421.16307863
20Chronic myeloid leukemia_Homo sapiens_hsa052201.16221460
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10126050
22Phospholipase D signaling pathway_Homo sapiens_hsa040721.06968908
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04899834
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.02774476
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02562569
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02314972
27Insulin resistance_Homo sapiens_hsa049311.01714042
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01453911
29Non-small cell lung cancer_Homo sapiens_hsa052230.98135590
30GnRH signaling pathway_Homo sapiens_hsa049120.95581850
31Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92589591
32Ovarian steroidogenesis_Homo sapiens_hsa049130.91219229
33Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91093096
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89379870
35Adipocytokine signaling pathway_Homo sapiens_hsa049200.88957352
36Glycerophospholipid metabolism_Homo sapiens_hsa005640.88815622
37Circadian rhythm_Homo sapiens_hsa047100.87830803
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86309661
39Endocytosis_Homo sapiens_hsa041440.85797028
40ECM-receptor interaction_Homo sapiens_hsa045120.85419054
41ABC transporters_Homo sapiens_hsa020100.85322315
42TNF signaling pathway_Homo sapiens_hsa046680.85115838
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84216481
44Insulin signaling pathway_Homo sapiens_hsa049100.83288440
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81518884
46Hepatitis C_Homo sapiens_hsa051600.79249400
47Melanogenesis_Homo sapiens_hsa049160.77242917
48Vitamin digestion and absorption_Homo sapiens_hsa049770.75908030
49Focal adhesion_Homo sapiens_hsa045100.75768219
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75351750
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71337254
52Hedgehog signaling pathway_Homo sapiens_hsa043400.70621604
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67719402
54Pancreatic cancer_Homo sapiens_hsa052120.67483778
55Choline metabolism in cancer_Homo sapiens_hsa052310.67082248
56B cell receptor signaling pathway_Homo sapiens_hsa046620.66660377
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.66572993
58Glioma_Homo sapiens_hsa052140.65530446
59Osteoclast differentiation_Homo sapiens_hsa043800.65038043
60AMPK signaling pathway_Homo sapiens_hsa041520.64918765
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64604134
62Estrogen signaling pathway_Homo sapiens_hsa049150.63665323
63ErbB signaling pathway_Homo sapiens_hsa040120.62724015
64Endometrial cancer_Homo sapiens_hsa052130.62283874
65Calcium signaling pathway_Homo sapiens_hsa040200.60841892
66Toxoplasmosis_Homo sapiens_hsa051450.59080413
67MAPK signaling pathway_Homo sapiens_hsa040100.58136106
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57599456
69Small cell lung cancer_Homo sapiens_hsa052220.57021259
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56132572
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55639313
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.54591976
73Bile secretion_Homo sapiens_hsa049760.54017753
74Axon guidance_Homo sapiens_hsa043600.53368778
75Taste transduction_Homo sapiens_hsa047420.52670053
76Cocaine addiction_Homo sapiens_hsa050300.51281370
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51171426
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50931660
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50854848
80Hepatitis B_Homo sapiens_hsa051610.50166462
81Arginine biosynthesis_Homo sapiens_hsa002200.49641399
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.49354339
83Proteoglycans in cancer_Homo sapiens_hsa052050.48835903
84Glucagon signaling pathway_Homo sapiens_hsa049220.47777794
85Long-term potentiation_Homo sapiens_hsa047200.47747625
86Prolactin signaling pathway_Homo sapiens_hsa049170.47222961
87Apoptosis_Homo sapiens_hsa042100.46828891
88Galactose metabolism_Homo sapiens_hsa000520.46643224
89Influenza A_Homo sapiens_hsa051640.45126118
90HTLV-I infection_Homo sapiens_hsa051660.45063584
91MicroRNAs in cancer_Homo sapiens_hsa052060.44303624
92Gap junction_Homo sapiens_hsa045400.44243220
93Renal cell carcinoma_Homo sapiens_hsa052110.43972137
94Hippo signaling pathway_Homo sapiens_hsa043900.39807366
95Prion diseases_Homo sapiens_hsa050200.38572108
96Platelet activation_Homo sapiens_hsa046110.38085675
97Dorso-ventral axis formation_Homo sapiens_hsa043200.38035610
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37357012
99Amoebiasis_Homo sapiens_hsa051460.36321387
100Pertussis_Homo sapiens_hsa051330.35935883

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