RTEL1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)8.07477504
2positive regulation by symbiont of host defense response (GO:0052509)7.21667118
3modulation by symbiont of host defense response (GO:0052031)7.21667118
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.21667118
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.21667118
6positive regulation by organism of defense response of other organism involved in symbiotic interact7.21667118
7modulation by symbiont of host immune response (GO:0052553)7.21667118
8positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)6.57114323
9positive regulation of gamma-delta T cell activation (GO:0046645)6.26807641
10microglial cell activation (GO:0001774)6.07430937
11macrophage activation involved in immune response (GO:0002281)5.74334220
12positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.36188224
13detection of external biotic stimulus (GO:0098581)5.23836357
14macrophage activation (GO:0042116)5.17658160
15cellular extravasation (GO:0045123)4.96389596
16regulation of B cell receptor signaling pathway (GO:0050855)4.95784105
17response to host immune response (GO:0052572)4.94914705
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.94914705
19regulation of interferon-beta biosynthetic process (GO:0045357)4.71297014
20regulation of gamma-delta T cell activation (GO:0046643)4.63587481
21response to host (GO:0075136)4.56702341
22response to host defenses (GO:0052200)4.56702341
23response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.56702341
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.56236507
25negative regulation of cell killing (GO:0031342)4.56236507
26detection of biotic stimulus (GO:0009595)4.52917782
27negative regulation of interleukin-12 production (GO:0032695)4.51324625
28regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.45788802
29response to peptidoglycan (GO:0032494)4.37716027
30neutrophil mediated immunity (GO:0002446)4.27990431
31detection of other organism (GO:0098543)4.16601842
32negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.09589158
33regulation of gamma-delta T cell differentiation (GO:0045586)4.02520036
34regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.92311220
35regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.89297706
36myeloid leukocyte mediated immunity (GO:0002444)3.89056756
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87940371
38hepatocyte apoptotic process (GO:0097284)3.79696736
39B cell receptor signaling pathway (GO:0050853)3.69093447
40I-kappaB phosphorylation (GO:0007252)3.66478100
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.65148542
42myeloid cell activation involved in immune response (GO:0002275)3.64347211
43negative regulation of T cell mediated immunity (GO:0002710)3.63820805
44regulation of interleukin-6 biosynthetic process (GO:0045408)3.62610216
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.56688697
46T-helper 1 type immune response (GO:0042088)3.56161551
47positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.45018386
48positive regulation of toll-like receptor signaling pathway (GO:0034123)3.42858285
49neutrophil activation involved in immune response (GO:0002283)3.42597894
50production of molecular mediator involved in inflammatory response (GO:0002532)3.42375342
51respiratory burst (GO:0045730)3.39837534
52regulation of interleukin-12 biosynthetic process (GO:0045075)3.35468497
53cellular response to ethanol (GO:0071361)3.22377877
54response to muramyl dipeptide (GO:0032495)3.22026071
55detection of bacterium (GO:0016045)3.20436777
56positive regulation of macrophage cytokine production (GO:0060907)3.18246624
57negative thymic T cell selection (GO:0045060)3.17625866
58positive regulation of interferon-alpha production (GO:0032727)3.17080134
59positive regulation of cellular amide metabolic process (GO:0034250)3.15417402
60response to interleukin-15 (GO:0070672)3.15389300
61regulation of necroptotic process (GO:0060544)3.14338932
62neutrophil activation (GO:0042119)3.12906107
63histone H3-K36 demethylation (GO:0070544)3.12125284
64negative T cell selection (GO:0043383)3.11610892
65germinal center formation (GO:0002467)3.11572387
66positive thymic T cell selection (GO:0045059)3.08819037
67negative regulation of interleukin-17 production (GO:0032700)3.07833468
68negative regulation of B cell proliferation (GO:0030889)3.03726322
69negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.00985131
70negative regulation of T-helper cell differentiation (GO:0045623)2.99536127
71negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.99536127
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99365677
73positive T cell selection (GO:0043368)2.98763655
74dosage compensation (GO:0007549)2.96448339
75negative regulation of immunoglobulin mediated immune response (GO:0002890)2.95713114
76negative regulation of B cell mediated immunity (GO:0002713)2.95713114
77negative regulation of leukocyte mediated immunity (GO:0002704)2.94473279
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93609297
79positive regulation of B cell differentiation (GO:0045579)2.91425490
80regulation of interferon-alpha production (GO:0032647)2.89664549
81phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.89400760
82defense response to protozoan (GO:0042832)2.89236802
83myeloid leukocyte activation (GO:0002274)2.87499309
84regulation of beta-amyloid formation (GO:1902003)2.87121010
85regulation of macrophage cytokine production (GO:0010935)2.86396484
86negative regulation of adaptive immune response (GO:0002820)2.85132046
87regulation of B cell differentiation (GO:0045577)2.81834759
88regulation of toll-like receptor signaling pathway (GO:0034121)2.77070373
89interferon-gamma production (GO:0032609)2.76844558
90antigen processing and presentation of endogenous antigen (GO:0019883)2.76107669
91lipopolysaccharide-mediated signaling pathway (GO:0031663)2.75590649
92iron ion import (GO:0097286)2.75325072
93granulocyte activation (GO:0036230)2.74863724
94positive regulation of interferon-beta production (GO:0032728)2.73784593
95cellular response to interleukin-15 (GO:0071350)2.72696432
96regulation of cellular amide metabolic process (GO:0034248)2.67289655
97antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.64364119
98regulation of myeloid leukocyte mediated immunity (GO:0002886)2.63138346
99negative regulation of toll-like receptor signaling pathway (GO:0034122)2.62391186
100neutrophil chemotaxis (GO:0030593)2.61168044

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.77219690
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.51031265
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.36130951
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.61578637
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.58125946
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39783505
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.32863299
8MYB_21317192_ChIP-Seq_ERMYB_Mouse3.30941773
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.07927915
10RUNX_20019798_ChIP-Seq_JUKART_Human3.05669506
11SMAD_19615063_ChIP-ChIP_OVARY_Human3.04762636
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.00103647
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.99138485
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.75698252
15SCL_19346495_ChIP-Seq_HPC-7_Human2.70798909
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63960332
17GATA1_22025678_ChIP-Seq_K562_Human2.53551648
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47936662
19SPI1_23127762_ChIP-Seq_K562_Human2.44643256
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.39639700
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38343692
22MYB_26560356_Chip-Seq_TH2_Human2.33891492
23SPI1_23547873_ChIP-Seq_NB4_Human2.33606753
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.31292225
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29497100
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28772530
27VDR_24787735_ChIP-Seq_THP-1_Human2.22755704
28VDR_24763502_ChIP-Seq_THP-1_Human2.17838460
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07378480
30MYB_26560356_Chip-Seq_TH1_Human2.00919526
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92749465
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89103764
33VDR_21846776_ChIP-Seq_THP-1_Human1.78849372
34GATA1_19941827_ChIP-Seq_MEL_Mouse1.76906548
35GATA3_27048872_Chip-Seq_THYMUS_Human1.74552540
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70388836
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.69188713
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.68801233
39PU_27001747_Chip-Seq_BMDM_Mouse1.66452752
40MAF_26560356_Chip-Seq_TH1_Human1.64380759
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63317640
42GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59273784
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.56159827
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.56094322
45GATA3_26560356_Chip-Seq_TH2_Human1.45195662
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42849326
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.42341386
48TCF7_22412390_ChIP-Seq_EML_Mouse1.42299817
49GATA2_19941826_ChIP-Seq_K562_Human1.36764229
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36547026
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35263710
52UTX_26944678_Chip-Seq_JUKART_Human1.32289480
53GATA1_19941826_ChIP-Seq_K562_Human1.30703494
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30406588
55TP53_16413492_ChIP-PET_HCT116_Human1.23872444
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22560326
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.20211005
58MYC_22102868_ChIP-Seq_BL_Human1.19889180
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16144907
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15184820
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10278388
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09900597
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08935553
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07967985
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07026314
66GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05735702
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05696725
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00812508
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00570688
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.00086360
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99181751
72MAF_26560356_Chip-Seq_TH2_Human0.98845048
73KDM2B_26808549_Chip-Seq_DND41_Human0.94686641
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94366218
75SMRT_27268052_Chip-Seq_Bcells_Human0.94327051
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92096277
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91058699
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90544538
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89256267
80KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88330792
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88119395
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86721925
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86198529
84FOXO3_23340844_ChIP-Seq_DLD1_Human0.84762311
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84454695
86FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81400758
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.80568250
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79161854
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78381098
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78286534
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76607178
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.73876686
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.73497015
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73439328
95KDM2B_26808549_Chip-Seq_JURKAT_Human0.73136643
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72795039
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.72795039
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72657175
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72186221
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.70585414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.98025148
2MP0000569_abnormal_digit_pigmentation4.69465390
3MP0008260_abnormal_autophagy3.97662882
4MP0003303_peritoneal_inflammation3.60449368
5MP0001835_abnormal_antigen_presentation3.14477706
6MP0005451_abnormal_body_composition2.83739605
7MP0003436_decreased_susceptibility_to2.80265759
8MP0000685_abnormal_immune_system2.57845960
9MP0008057_abnormal_DNA_replication2.54939036
10MP0002419_abnormal_innate_immunity2.53343459
11MP0004381_abnormal_hair_follicle2.52879740
12MP0001800_abnormal_humoral_immune2.46142100
13MP0003172_abnormal_lysosome_physiology2.44141146
14MP0003656_abnormal_erythrocyte_physiolo2.28403694
15MP0002723_abnormal_immune_serum2.08746964
16MP0003828_pulmonary_edema2.06484865
17MP0005025_abnormal_response_to2.04745942
18MP0005000_abnormal_immune_tolerance2.03986617
19MP0002452_abnormal_antigen_presenting2.02254884
20MP0003183_abnormal_peptide_metabolism2.01667975
21MP0002420_abnormal_adaptive_immunity1.97360251
22MP0003763_abnormal_thymus_physiology1.95820162
23MP0001819_abnormal_immune_cell1.95148955
24MP0004883_abnormal_blood_vessel1.93570446
25MP0009785_altered_susceptibility_to1.92809625
26MP0005387_immune_system_phenotype1.89927824
27MP0001790_abnormal_immune_system1.89927824
28MP0009278_abnormal_bone_marrow1.85794358
29MP0003300_gastrointestinal_ulcer1.85294531
30MP0002396_abnormal_hematopoietic_system1.85109003
31MP0005464_abnormal_platelet_physiology1.84671612
32MP0000015_abnormal_ear_pigmentation1.81493539
33MP0002166_altered_tumor_susceptibility1.81149043
34MP0002332_abnormal_exercise_endurance1.79771654
35MP0005671_abnormal_response_to1.79209349
36MP0003787_abnormal_imprinting1.74582814
37MP0003221_abnormal_cardiomyocyte_apopto1.68601212
38MP0003191_abnormal_cellular_cholesterol1.67138987
39MP0002398_abnormal_bone_marrow1.65921800
40MP0000716_abnormal_immune_system1.58916134
41MP0002405_respiratory_system_inflammati1.58217263
42MP0005397_hematopoietic_system_phenotyp1.54048277
43MP0001545_abnormal_hematopoietic_system1.54048277
44MP0006082_CNS_inflammation1.52252269
45MP0001533_abnormal_skeleton_physiology1.51943341
46MP0009764_decreased_sensitivity_to1.49627525
47MP0005164_abnormal_response_to1.48305620
48MP0002722_abnormal_immune_system1.43837677
49MP0000689_abnormal_spleen_morphology1.41196992
50MP0005174_abnormal_tail_pigmentation1.39907452
51MP0002132_abnormal_respiratory_system1.39385269
52MP0004947_skin_inflammation1.34154424
53MP0001845_abnormal_inflammatory_respons1.31838946
54MP0005075_abnormal_melanosome_morpholog1.29718919
55MP0002148_abnormal_hypersensitivity_rea1.28251583
56MP0005310_abnormal_salivary_gland1.26649256
57MP0002277_abnormal_respiratory_mucosa1.25218573
58MP0002429_abnormal_blood_cell1.25208723
59MP0003866_abnormal_defecation1.24415866
60MP0000703_abnormal_thymus_morphology1.24179824
61MP0005076_abnormal_cell_differentiation1.21437391
62MP0000465_gastrointestinal_hemorrhage1.21264754
63MP0002006_tumorigenesis1.18160483
64MP0004484_altered_response_of1.17501306
65MP0003690_abnormal_glial_cell1.10319093
66MP0004808_abnormal_hematopoietic_stem1.09844052
67MP0000858_altered_metastatic_potential1.09820381
68MP0000604_amyloidosis1.00696178
69MP0003091_abnormal_cell_migration1.00341108
70MP0010155_abnormal_intestine_physiology0.99773447
71MP0002998_abnormal_bone_remodeling0.98604386
72MP0003045_fibrosis0.97382277
73MP0003075_altered_response_to0.94067838
74MP0008469_abnormal_protein_level0.93290477
75MP0001851_eye_inflammation0.93178634
76MP0004130_abnormal_muscle_cell0.92046892
77MP0002009_preneoplasia0.89387402
78MP0008877_abnormal_DNA_methylation0.89281878
79MP0000371_diluted_coat_color0.87387409
80MP0003646_muscle_fatigue0.83500394
81MP0001853_heart_inflammation0.83231438
82MP0005376_homeostasis/metabolism_phenot0.83132083
83MP0008004_abnormal_stomach_pH0.79006092
84MP0005266_abnormal_metabolism0.78495027
85MP0009763_increased_sensitivity_to0.74942303
86MP0009765_abnormal_xenobiotic_induced0.72518632
87MP0000249_abnormal_blood_vessel0.70530177
88MP0003329_amyloid_beta_deposits0.70019520
89MP0005166_decreased_susceptibility_to0.67534792
90MP0009115_abnormal_fat_cell0.66238583
91MP0009333_abnormal_splenocyte_physiolog0.65800782
92MP0003448_altered_tumor_morphology0.65462121
93MP0005621_abnormal_cell_physiology0.65290370
94MP0002163_abnormal_gland_morphology0.63537982
95MP0008874_decreased_physiological_sensi0.62020864
96MP0001958_emphysema0.61878433
97MP0010352_gastrointestinal_tract_polyps0.59239373
98MP0004510_myositis0.59039088
99MP0003632_abnormal_nervous_system0.57390525
100MP0000427_abnormal_hair_cycle0.57082398

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.66564620
2Retrobulbar optic neuritis (HP:0100654)5.53698118
3Optic neuritis (HP:0100653)5.53698118
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.49644943
5Orchitis (HP:0100796)5.41752186
6Myositis (HP:0100614)5.08834244
7Recurrent abscess formation (HP:0002722)5.06848371
8Eczematoid dermatitis (HP:0000976)4.99318142
9Recurrent fungal infections (HP:0002841)4.23030543
10T lymphocytopenia (HP:0005403)4.14522086
11Keratoconjunctivitis sicca (HP:0001097)4.13606701
12Abnormality of T cell number (HP:0011839)3.94905379
13Recurrent skin infections (HP:0001581)3.86879730
14Recurrent gram-negative bacterial infections (HP:0005420)3.84435622
15Recurrent cutaneous fungal infections (HP:0011370)3.82103187
16Chronic mucocutaneous candidiasis (HP:0002728)3.82103187
17Gastrointestinal infarctions (HP:0005244)3.77336522
18Keratoconjunctivitis (HP:0001096)3.77320116
19Gingivitis (HP:0000230)3.60363811
20Arterial thrombosis (HP:0004420)3.53239838
21Peritonitis (HP:0002586)3.49241390
22Mediastinal lymphadenopathy (HP:0100721)3.44731248
23Spontaneous hematomas (HP:0007420)3.39430539
24Gingival bleeding (HP:0000225)3.37655837
25Abnormality of macrophages (HP:0004311)3.32700225
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.26559309
27Slow saccadic eye movements (HP:0000514)3.14473579
28Encephalitis (HP:0002383)3.14455841
29Elevated erythrocyte sedimentation rate (HP:0003565)3.12702914
30Meningitis (HP:0001287)3.11202262
31Stomatitis (HP:0010280)2.96378428
32Subacute progressive viral hepatitis (HP:0006572)2.90396843
33Hemoptysis (HP:0002105)2.89778343
34Vasculitis (HP:0002633)2.88036081
35Periodontitis (HP:0000704)2.85691609
36Recurrent viral infections (HP:0004429)2.83025970
37Difficulty running (HP:0009046)2.82934773
38Chest pain (HP:0100749)2.82515175
39Abnormality of T cells (HP:0002843)2.76211446
40Recurrent bronchitis (HP:0002837)2.73144596
41Abnormality of the peritoneum (HP:0002585)2.69929497
42Thoracolumbar scoliosis (HP:0002944)2.65980478
43Postural instability (HP:0002172)2.63820072
44Leukocytosis (HP:0001974)2.63198444
45Urticaria (HP:0001025)2.61749475
46Chronic obstructive pulmonary disease (HP:0006510)2.60885619
47Obstructive lung disease (HP:0006536)2.60885619
48Anorexia (HP:0002039)2.55584497
49Cellulitis (HP:0100658)2.54269114
50Resting tremor (HP:0002322)2.49786295
51Epistaxis (HP:0000421)2.46434625
52Colitis (HP:0002583)2.45289691
53Viral hepatitis (HP:0006562)2.43631664
54Inflammation of the large intestine (HP:0002037)2.41415123
55Pulmonary embolism (HP:0002204)2.34958992
56Abnormality of the endocardium (HP:0004306)2.34417024
57Abnormality of the fingertips (HP:0001211)2.34230856
58Gangrene (HP:0100758)2.30297841
59Eosinophilia (HP:0001880)2.28028928
60Pulmonary infiltrates (HP:0002113)2.25993924
61Increased connective tissue (HP:0009025)2.19933851
62Gastrointestinal inflammation (HP:0004386)2.19094153
63Granulocytopenia (HP:0001913)2.14549284
64Prolonged bleeding time (HP:0003010)2.13759237
65Acute hepatic failure (HP:0006554)2.13713478
66Keratitis (HP:0000491)2.11657527
67Visual hallucinations (HP:0002367)2.10866179
68Abnormality of the vasculature of the conjunctiva (HP:0008054)2.07726893
69Autoimmune hemolytic anemia (HP:0001890)2.05814721
70Glomerulopathy (HP:0100820)2.02042004
71Vertigo (HP:0002321)2.02021181
72Abnormality of the pleura (HP:0002103)1.96323633
73Increased IgE level (HP:0003212)1.92878958
74Pelvic girdle muscle weakness (HP:0003749)1.91877946
75Osteomyelitis (HP:0002754)1.91180809
76Papillary thyroid carcinoma (HP:0002895)1.89747398
77Cheilitis (HP:0100825)1.89654691
78Abnormality of eosinophils (HP:0001879)1.88923686
79Episodic fever (HP:0001954)1.87353830
80Segmental peripheral demyelination/remyelination (HP:0003481)1.84354236
81Autoimmune thrombocytopenia (HP:0001973)1.83453285
82Acne (HP:0001061)1.82646904
83Amyloidosis (HP:0011034)1.81446226
84Abnormality of T cell physiology (HP:0011840)1.80569827
85Amaurosis fugax (HP:0100576)1.79354294
86Sepsis (HP:0100806)1.78902327
87Fatigue (HP:0012378)1.78261940
88Thrombophlebitis (HP:0004418)1.73428568
89Conjunctival telangiectasia (HP:0000524)1.73340324
90Genetic anticipation (HP:0003743)1.71669228
91Abnormality of glycolipid metabolism (HP:0010969)1.71353763
92Abnormality of liposaccharide metabolism (HP:0010968)1.71353763
93Abnormality of glycosphingolipid metabolism (HP:0004343)1.71353763
94Microcytic anemia (HP:0001935)1.71158894
95Bilateral sensorineural hearing impairment (HP:0008619)1.70469900
96IgM deficiency (HP:0002850)1.69928906
97Paresthesia (HP:0003401)1.68159543
98Hypochromic anemia (HP:0001931)1.68017277
99Onion bulb formation (HP:0003383)1.67362831
100Myocardial infarction (HP:0001658)1.66688613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.36639769
2RIPK43.61803313
3IRAK43.48606285
4MAP2K33.24109807
5IRAK12.36226415
6IRAK22.25336036
7IKBKE2.22973993
8INSRR2.20809786
9CSK2.19946972
10GRK62.15648520
11MAP3K142.09453599
12MAP4K12.05671959
13TAOK31.99636604
14MAP3K21.96896779
15TYK21.92016808
16FGR1.90296566
17JAK31.81522218
18PIK3CG1.78067640
19EPHB11.76133799
20SYK1.72773135
21ZAP701.69215188
22FES1.67493982
23FRK1.66011795
24WNK11.65944049
25TXK1.59989462
26JAK11.48563748
27SGK21.47316344
28MAP3K31.43474562
29JAK21.41928865
30BTK1.39786969
31MAP3K61.37818603
32HCK1.37751288
33FGFR31.33280107
34KSR21.28365168
35SGK31.22845294
36MAP3K11.21073804
37YES11.19195333
38PTK2B1.15343148
39BMPR21.14728891
40STK41.12567224
41MATK1.11125402
42LYN1.10570945
43ERN11.05160446
44RAF11.00826817
45TEC1.00575960
46MAP2K40.97271614
47CDK120.97044967
48TGFBR20.95818933
49AKT30.94741377
50PRPF4B0.94377133
51MARK20.93201788
52PIM10.91495636
53TAOK10.90852082
54MAP3K130.89253251
55CSF1R0.88521959
56TBK10.88184365
57MAP3K50.81240262
58EPHA30.81128717
59LCK0.80566102
60ITK0.80241433
61TRPM70.78094973
62SGK4940.75396477
63SGK2230.75396477
64ACVR1B0.73694000
65NEK90.72921555
66KIT0.72462018
67KSR10.72129155
68IKBKB0.71459234
69MARK30.71288679
70NLK0.69960911
71PDK10.69864396
72ERBB20.69575986
73LRRK20.68646563
74CHUK0.66696735
75MAP3K110.66437064
76NEK60.66357851
77FGFR40.64116099
78STK110.60916836
79GRK50.60374706
80STK380.56732465
81SGK10.55925961
82MAP3K70.55287565
83TNK20.53727058
84PDPK10.53716094
85RET0.50723845
86CAMK40.48087705
87PRKAA20.47555514
88CDC42BPA0.47405822
89STK100.46992310
90HIPK20.46751239
91MAPK120.46646091
92MAP2K60.46108248
93CDK60.44830918
94CAMK1D0.41204656
95MELK0.41195144
96TTN0.40811996
97PAK30.39100563
98EGFR0.38532218
99MAPK70.38025248
100FYN0.33919086

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.99171005
2Osteoclast differentiation_Homo sapiens_hsa043802.70612995
3B cell receptor signaling pathway_Homo sapiens_hsa046622.54074936
4Staphylococcus aureus infection_Homo sapiens_hsa051502.32555721
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.30384273
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.29884627
7Tuberculosis_Homo sapiens_hsa051522.25534052
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.25373593
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.95289171
10Legionellosis_Homo sapiens_hsa051341.94483123
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.91729942
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83328399
13Non-small cell lung cancer_Homo sapiens_hsa052231.81958386
14Measles_Homo sapiens_hsa051621.80657883
15Malaria_Homo sapiens_hsa051441.75280653
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73316454
17Acute myeloid leukemia_Homo sapiens_hsa052211.72562290
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66597689
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.63445428
20T cell receptor signaling pathway_Homo sapiens_hsa046601.63305175
21Influenza A_Homo sapiens_hsa051641.56331366
22Toxoplasmosis_Homo sapiens_hsa051451.53505672
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52768822
24Hepatitis B_Homo sapiens_hsa051611.52753119
25TNF signaling pathway_Homo sapiens_hsa046681.52521426
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.50612481
27Chemokine signaling pathway_Homo sapiens_hsa040621.48282215
28Dorso-ventral axis formation_Homo sapiens_hsa043201.43297390
29Pancreatic cancer_Homo sapiens_hsa052121.39927639
30Platelet activation_Homo sapiens_hsa046111.33236222
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32525523
32Chronic myeloid leukemia_Homo sapiens_hsa052201.29548549
33Prolactin signaling pathway_Homo sapiens_hsa049171.28425554
34Hepatitis C_Homo sapiens_hsa051601.23681150
35FoxO signaling pathway_Homo sapiens_hsa040681.21301091
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18998894
37Inositol phosphate metabolism_Homo sapiens_hsa005621.18375566
38Hematopoietic cell lineage_Homo sapiens_hsa046401.15947511
39Apoptosis_Homo sapiens_hsa042101.14791487
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.11724036
41Renal cell carcinoma_Homo sapiens_hsa052111.06367650
42Primary immunodeficiency_Homo sapiens_hsa053401.05027539
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04280744
44VEGF signaling pathway_Homo sapiens_hsa043701.03893562
45Endometrial cancer_Homo sapiens_hsa052131.03175114
46Herpes simplex infection_Homo sapiens_hsa051681.00299471
47Phagosome_Homo sapiens_hsa041450.99341713
48GnRH signaling pathway_Homo sapiens_hsa049120.97865339
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.94587851
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92504522
51Prostate cancer_Homo sapiens_hsa052150.92243600
52Graft-versus-host disease_Homo sapiens_hsa053320.88768455
53Viral carcinogenesis_Homo sapiens_hsa052030.88378384
54mTOR signaling pathway_Homo sapiens_hsa041500.87881377
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.83956247
56Pertussis_Homo sapiens_hsa051330.82494222
57ErbB signaling pathway_Homo sapiens_hsa040120.81650992
58Glioma_Homo sapiens_hsa052140.81530025
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81136583
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80595275
61Insulin resistance_Homo sapiens_hsa049310.80150245
62HIF-1 signaling pathway_Homo sapiens_hsa040660.78907969
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.78766349
64Allograft rejection_Homo sapiens_hsa053300.77657876
65Notch signaling pathway_Homo sapiens_hsa043300.76788941
66Type II diabetes mellitus_Homo sapiens_hsa049300.76205720
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75766187
68Autoimmune thyroid disease_Homo sapiens_hsa053200.73460662
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.73226353
70African trypanosomiasis_Homo sapiens_hsa051430.71954160
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71442023
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70373470
73Choline metabolism in cancer_Homo sapiens_hsa052310.69856439
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69802041
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69601302
76Shigellosis_Homo sapiens_hsa051310.62567187
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62068744
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60759505
79Small cell lung cancer_Homo sapiens_hsa052220.59921915
80Salmonella infection_Homo sapiens_hsa051320.59328218
81Estrogen signaling pathway_Homo sapiens_hsa049150.59259659
82Colorectal cancer_Homo sapiens_hsa052100.59065276
83MAPK signaling pathway_Homo sapiens_hsa040100.58774035
84Amoebiasis_Homo sapiens_hsa051460.57162000
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56934746
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56583671
87Long-term potentiation_Homo sapiens_hsa047200.52229251
88Antigen processing and presentation_Homo sapiens_hsa046120.51861065
89Epstein-Barr virus infection_Homo sapiens_hsa051690.50450088
90Systemic lupus erythematosus_Homo sapiens_hsa053220.47929500
91Regulation of autophagy_Homo sapiens_hsa041400.47396213
92Viral myocarditis_Homo sapiens_hsa054160.47339303
93Insulin signaling pathway_Homo sapiens_hsa049100.45940118
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45629546
95Type I diabetes mellitus_Homo sapiens_hsa049400.45258902
96Endocytosis_Homo sapiens_hsa041440.44478232
97MicroRNAs in cancer_Homo sapiens_hsa052060.44413064
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.44210617
99Lysosome_Homo sapiens_hsa041420.44038651
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.43597262

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