RTF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.39703905
2establishment of mitochondrion localization (GO:0051654)4.59602941
3exploration behavior (GO:0035640)4.48410798
4pre-miRNA processing (GO:0031054)4.40491688
5behavioral response to nicotine (GO:0035095)4.37143526
6polyketide metabolic process (GO:0030638)4.28583358
7doxorubicin metabolic process (GO:0044598)4.28583358
8daunorubicin metabolic process (GO:0044597)4.28583358
9negative regulation of necroptotic process (GO:0060546)4.27214147
10viral transcription (GO:0019083)4.21268582
11establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.19647962
12mitochondrion transport along microtubule (GO:0047497)4.19647962
13heterochromatin organization (GO:0070828)4.14203609
14translational termination (GO:0006415)4.08577432
15regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07375132
16substrate-independent telencephalic tangential migration (GO:0021826)4.07000404
17substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.07000404
18nucleobase catabolic process (GO:0046113)4.00755802
19negative regulation of epidermis development (GO:0045683)3.91378707
20short-term memory (GO:0007614)3.88297302
21neuron recognition (GO:0008038)3.75382599
22histone H4-K12 acetylation (GO:0043983)3.73256521
23postsynaptic membrane organization (GO:0001941)3.65961698
24protein localization to kinetochore (GO:0034501)3.64032967
25cell proliferation in forebrain (GO:0021846)3.64008150
26negative regulation of necrotic cell death (GO:0060547)3.59572625
27positive regulation of T cell cytokine production (GO:0002726)3.52526361
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.43226773
29maturation of SSU-rRNA (GO:0030490)3.42236723
30neurofilament cytoskeleton organization (GO:0060052)3.40078587
31maintenance of protein location in nucleus (GO:0051457)3.37933950
32negative regulation of epidermal cell differentiation (GO:0045605)3.37921537
33translational elongation (GO:0006414)3.31158986
34cerebral cortex radially oriented cell migration (GO:0021799)3.26754984
35axonal fasciculation (GO:0007413)3.25486870
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19925781
37specification of organ identity (GO:0010092)3.19534575
38cellular protein complex disassembly (GO:0043624)3.18622971
39histone H4-K5 acetylation (GO:0043981)3.14762901
40histone H4-K8 acetylation (GO:0043982)3.14762901
41RNA stabilization (GO:0043489)3.13993732
42mRNA stabilization (GO:0048255)3.13993732
43somite rostral/caudal axis specification (GO:0032525)3.13970223
44axon extension (GO:0048675)3.12720731
45neural tube formation (GO:0001841)3.11826703
46protein complex disassembly (GO:0043241)3.08805110
47nuclear pore complex assembly (GO:0051292)3.08129653
48somite development (GO:0061053)3.07377930
49chromatin assembly (GO:0031497)3.05730048
50dendritic spine morphogenesis (GO:0060997)3.03848872
51macromolecular complex disassembly (GO:0032984)3.03313346
52ventricular system development (GO:0021591)3.02793256
53behavioral response to cocaine (GO:0048148)3.01877846
54viral life cycle (GO:0019058)3.00882994
55neuron cell-cell adhesion (GO:0007158)3.00661704
56cotranslational protein targeting to membrane (GO:0006613)3.00647521
57regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.99718675
58mitotic sister chromatid segregation (GO:0000070)2.99606906
59protein targeting to ER (GO:0045047)2.99508140
60regulation of nuclear cell cycle DNA replication (GO:0033262)2.99482233
61synaptic vesicle maturation (GO:0016188)2.98327400
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97784788
63spinal cord development (GO:0021510)2.97657083
64chaperone-mediated protein transport (GO:0072321)2.96812740
65positive regulation of gastrulation (GO:2000543)2.96275036
66histone arginine methylation (GO:0034969)2.96237627
67mitotic sister chromatid cohesion (GO:0007064)2.96237536
68hindbrain development (GO:0030902)2.95759746
69histone H4-K16 acetylation (GO:0043984)2.95683544
70sister chromatid segregation (GO:0000819)2.95233845
71regulation of helicase activity (GO:0051095)2.93555771
72ribosomal small subunit assembly (GO:0000028)2.92926644
73proline transport (GO:0015824)2.92741535
74negative regulation of glial cell proliferation (GO:0060253)2.87799005
75regulation of necroptotic process (GO:0060544)2.86670708
76presynaptic membrane organization (GO:0097090)2.86093873
77establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86008516
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.85644053
79negative regulation of cell killing (GO:0031342)2.85644053
80behavioral response to ethanol (GO:0048149)2.85209310
81negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.85145651
82transmission of nerve impulse (GO:0019226)2.83654345
83mechanosensory behavior (GO:0007638)2.83065905
84negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.82653358
85establishment of endothelial barrier (GO:0061028)2.82622046
86negative regulation of potassium ion transmembrane transport (GO:1901380)2.80952976
87protein localization to chromosome, centromeric region (GO:0071459)2.79609870
88DNA unwinding involved in DNA replication (GO:0006268)2.79101012
89NLS-bearing protein import into nucleus (GO:0006607)2.78578455
90regulation of response to osmotic stress (GO:0047484)2.78530951
91regulation of MHC class I biosynthetic process (GO:0045343)2.76225180
92regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.75799406
93regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.75799406
94retinal ganglion cell axon guidance (GO:0031290)2.75405423
95positive regulation of synapse assembly (GO:0051965)2.73184389
96auditory behavior (GO:0031223)2.73053869
97neuron projection extension (GO:1990138)2.72969379
98protein localization to endoplasmic reticulum (GO:0070972)2.72639565
99protein-DNA complex disassembly (GO:0032986)2.70470752
100nucleosome disassembly (GO:0006337)2.70470752
101membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69772733
102thalamus development (GO:0021794)2.69753328
103forebrain neuron differentiation (GO:0021879)2.69153253
104regulation of mammary gland epithelial cell proliferation (GO:0033599)2.68876446
105presynaptic membrane assembly (GO:0097105)2.68154501
106positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67840625
107body morphogenesis (GO:0010171)2.67522790
108negative regulation of cell cycle G2/M phase transition (GO:1902750)2.67359606
109trophectodermal cell differentiation (GO:0001829)2.66789409
110inner ear receptor cell development (GO:0060119)2.66787009
111negative regulation of histone methylation (GO:0031061)2.65785480
112negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64750079
113behavioral fear response (GO:0001662)2.64587509
114behavioral defense response (GO:0002209)2.64587509
115central nervous system projection neuron axonogenesis (GO:0021952)2.62869316
116regulation of gene silencing by RNA (GO:0060966)2.62155253
117regulation of posttranscriptional gene silencing (GO:0060147)2.62155253
118regulation of gene silencing by miRNA (GO:0060964)2.62155253
119alternative mRNA splicing, via spliceosome (GO:0000380)2.61250349
120dendrite morphogenesis (GO:0048813)2.61064620
121negative regulation of organelle assembly (GO:1902116)2.60690994
122positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.60134328
123genetic imprinting (GO:0071514)2.60041749
124regulation of membrane repolarization (GO:0060306)2.59982929
125* histone H3-K4 methylation (GO:0051568)2.59946533
126translational initiation (GO:0006413)2.57600918
127organelle disassembly (GO:1903008)2.57599222
128adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.57250814
129regulation of telomere maintenance via telomerase (GO:0032210)2.57223079
130dendrite development (GO:0016358)2.57097870
131otic vesicle formation (GO:0030916)2.56724432
132positive regulation of sodium ion transmembrane transport (GO:1902307)2.56645597
133interferon-gamma production (GO:0032609)2.56437401
134positive regulation of dendritic spine morphogenesis (GO:0061003)2.56061687
135histone H3 acetylation (GO:0043966)2.55694092
136mRNA splice site selection (GO:0006376)2.55524346
137head development (GO:0060322)2.55023488
138retina layer formation (GO:0010842)2.54910435
139notochord development (GO:0030903)2.54703235
140intracellular estrogen receptor signaling pathway (GO:0030520)2.54625862
141positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.54392999
142nuclear pore organization (GO:0006999)2.53698016
143vocalization behavior (GO:0071625)2.53471793
144dopamine receptor signaling pathway (GO:0007212)2.53435597
145camera-type eye morphogenesis (GO:0048593)2.52226213
146collecting duct development (GO:0072044)2.51980041
147response to histamine (GO:0034776)2.51646059
148positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.51037841
149negative regulation of telomerase activity (GO:0051974)2.48463862
150regulation of feeding behavior (GO:0060259)2.48367691
151hippocampus development (GO:0021766)2.47952922
152lens fiber cell development (GO:0070307)2.47829469
153regulation of synapse structural plasticity (GO:0051823)2.47502849
154nonmotile primary cilium assembly (GO:0035058)2.47274730
155gap junction assembly (GO:0016264)2.47088047
156protein localization to synapse (GO:0035418)2.46129344
157axon extension involved in axon guidance (GO:0048846)2.46092546
158neuron projection extension involved in neuron projection guidance (GO:1902284)2.46092546
159intestinal epithelial cell development (GO:0060576)2.44410969
160phenol-containing compound catabolic process (GO:0019336)2.43473689
161layer formation in cerebral cortex (GO:0021819)2.43331183
162regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.43125688
163mucosal-associated lymphoid tissue development (GO:0048537)2.41692180
164Peyers patch development (GO:0048541)2.41692180
165ribosomal small subunit biogenesis (GO:0042274)2.40930038
166histone H3-K9 methylation (GO:0051567)2.38840230
167regulation of telomere maintenance (GO:0032204)2.38756144
168aminoglycoside antibiotic metabolic process (GO:0030647)2.38510362
169cardiovascular system development (GO:0072358)2.37047256
170regulation of T cell cytokine production (GO:0002724)2.36360417
171protein localization to chromosome (GO:0034502)2.35154034
172G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.32523540
173pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.32080962
174regulation of gamma-delta T cell differentiation (GO:0045586)2.31759955
175primitive streak formation (GO:0090009)2.31010848
176ionotropic glutamate receptor signaling pathway (GO:0035235)2.30987111
177regulation of mRNA stability (GO:0043488)2.30840492
178membrane hyperpolarization (GO:0060081)2.30392834
179positive regulation of histone deacetylation (GO:0031065)2.30213478
180negative regulation of thymocyte apoptotic process (GO:0070244)2.28602689
181positive regulation of smoothened signaling pathway (GO:0045880)2.28118343
182positive regulation of DNA-dependent DNA replication (GO:2000105)2.28014658
183detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.27738403
184cell migration in hindbrain (GO:0021535)2.27494870
185long-term memory (GO:0007616)2.27013074
186epithelial cell-cell adhesion (GO:0090136)2.26340783
187locomotory exploration behavior (GO:0035641)2.26307244
188apoptotic DNA fragmentation (GO:0006309)2.25458551
189peptidyl-threonine phosphorylation (GO:0018107)2.22448579
190muscle organ morphogenesis (GO:0048644)2.21984269

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.05916105
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.05916105
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.05916105
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.67414144
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.62740003
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.56968717
7E2F7_22180533_ChIP-Seq_HELA_Human4.49787848
8EZH2_22144423_ChIP-Seq_EOC_Human4.04157513
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.65047721
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.03961202
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.01087705
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.66144742
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.41538585
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39553330
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.31740360
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22545404
17RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.21947105
18ZFP281_27345836_Chip-Seq_ESCs_Mouse2.20046637
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.19137459
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.14596053
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.13164329
22ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10219476
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.07317956
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.06093757
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05553910
26MYC_22102868_ChIP-Seq_BL_Human2.03710633
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.01574943
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.94697162
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.94214984
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90722557
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.90064578
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88607936
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82105652
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80247671
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79051791
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78789266
37NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.76582186
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75870658
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73609536
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69239468
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68452798
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.67333005
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.66363639
44ZNF274_21170338_ChIP-Seq_K562_Hela1.66143871
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64366899
46OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.61493099
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.60474685
48NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.60060335
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58426698
50TCF7_22412390_ChIP-Seq_EML_Mouse1.54011430
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48149519
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48149519
53CDX2_20551321_ChIP-Seq_CACO-2_Human1.47781765
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47439503
55SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.45207063
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44751255
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43142345
58VDR_22108803_ChIP-Seq_LS180_Human1.41162007
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.40226790
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.39031861
61KDM2B_26808549_Chip-Seq_DND41_Human1.38077616
62TCF3_18692474_ChIP-Seq_MESCs_Mouse1.36704086
63KDM2B_26808549_Chip-Seq_K562_Human1.34143528
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33891408
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.32438423
66POU5F1_16518401_ChIP-PET_MESCs_Mouse1.30243453
67GBX2_23144817_ChIP-Seq_PC3_Human1.30024291
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27907606
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26844608
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26826515
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26735771
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.26380889
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25815008
74CTCF_27219007_Chip-Seq_Bcells_Human1.24398370
75RNF2_27304074_Chip-Seq_NSC_Mouse1.22714857
76FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21858524
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19799395
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19517367
79TP53_16413492_ChIP-PET_HCT116_Human1.18932842
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18925287
81DROSHA_22980978_ChIP-Seq_HELA_Human1.18251555
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.13798232
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13307588
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12630798
85TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.11943083
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11422744
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10770389
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.09697858
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.08393129
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08348870
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07273731
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06665842
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05937946
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05480397
95REST_21632747_ChIP-Seq_MESCs_Mouse1.04748301
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02638459
97POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02090634
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01810019
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01810019
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00540677
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00478000
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99730419
103JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99726021
104P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99418862
105PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99410995
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98785167
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98048620
108IRF1_19129219_ChIP-ChIP_H3396_Human0.97411171
109TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96555406
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96279617
111CREB1_26743006_Chip-Seq_LNCaP_Human0.95928340
112CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95896048
113MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95583830
114PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95314257
115* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95113861
116XRN2_22483619_ChIP-Seq_HELA_Human0.94202894
117TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94037196
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.93942845
119VDR_21846776_ChIP-Seq_THP-1_Human0.93670844
120EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93115466
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92525991
122KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90550767
123MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90119272
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90079229
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.89875434
126SOX3_22085726_ChIP-Seq_NPCs_Mouse0.89711267
127ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89155654
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.89052178
129AHR_22903824_ChIP-Seq_MCF-7_Human0.88555581
130BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88540749
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.87263505
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87001884
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85874179
134WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85103897
135THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84269224
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84099845
137STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84049665
138TAF15_26573619_Chip-Seq_HEK293_Human0.83725322
139MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83648191
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82905486
141HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.82711517
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81844774
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.81262267
144TTF2_22483619_ChIP-Seq_HELA_Human0.81013388
145SUZ12_27294783_Chip-Seq_ESCs_Mouse0.80686178
146DPY_21335234_ChIP-Seq_ESCs_Mouse0.80488127
147SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79965252
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79899992
149RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79454773
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78974168
151CIITA_25753668_ChIP-Seq_RAJI_Human0.78738574
152ERG_21242973_ChIP-ChIP_JURKAT_Human0.78356250
153AR_19668381_ChIP-Seq_PC3_Human0.78168121
154NANOG_18692474_ChIP-Seq_MESCs_Mouse0.78156259
155POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.77655593
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76910608
157MYC_18555785_ChIP-Seq_MESCs_Mouse0.76788569
158CTBP2_25329375_ChIP-Seq_LNCAP_Human0.76032842
159WDR5_24793694_ChIP-Seq_LNCAP_Human0.74302454

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.20727996
2MP0003122_maternal_imprinting3.11086319
3MP0004859_abnormal_synaptic_plasticity2.88879558
4MP0006292_abnormal_olfactory_placode2.88303125
5MP0003787_abnormal_imprinting2.88253090
6MP0008057_abnormal_DNA_replication2.72253884
7MP0002009_preneoplasia2.66477621
8MP0003121_genomic_imprinting2.55433859
9MP0004264_abnormal_extraembryonic_tissu2.38804222
10MP0001188_hyperpigmentation2.22155822
11MP0005499_abnormal_olfactory_system2.21521666
12MP0005394_taste/olfaction_phenotype2.21521666
13MP0005423_abnormal_somatic_nervous2.20972341
14MP0003938_abnormal_ear_development2.19305363
15MP0003890_abnormal_embryonic-extraembry2.03118094
16MP0004957_abnormal_blastocyst_morpholog2.00360582
17MP0000955_abnormal_spinal_cord1.91171328
18MP0003123_paternal_imprinting1.84105722
19MP0003880_abnormal_central_pattern1.83972503
20MP0004145_abnormal_muscle_electrophysio1.81931759
21MP0003300_gastrointestinal_ulcer1.81658824
22MP0001529_abnormal_vocalization1.77047639
23MP0003635_abnormal_synaptic_transmissio1.69668922
24MP0001440_abnormal_grooming_behavior1.66565721
25MP0002254_reproductive_system_inflammat1.62875856
26MP0004858_abnormal_nervous_system1.54031751
27MP0003136_yellow_coat_color1.52855916
28MP0004742_abnormal_vestibular_system1.52760570
29MP0004142_abnormal_muscle_tone1.51463569
30MP0000778_abnormal_nervous_system1.46749941
31MP0008961_abnormal_basal_metabolism1.45556618
32MP0002063_abnormal_learning/memory/cond1.44463862
33MP0002734_abnormal_mechanical_nocicepti1.44428746
34MP0004233_abnormal_muscle_weight1.42878272
35MP0010352_gastrointestinal_tract_polyps1.42327578
36MP0003937_abnormal_limbs/digits/tail_de1.39774366
37MP0001485_abnormal_pinna_reflex1.37605877
38MP0002882_abnormal_neuron_morphology1.37484582
39MP0002572_abnormal_emotion/affect_behav1.35954667
40MP0002102_abnormal_ear_morphology1.34963438
41MP0004811_abnormal_neuron_physiology1.34610157
42MP0003119_abnormal_digestive_system1.33418013
43MP0004133_heterotaxia1.32912493
44MP0000049_abnormal_middle_ear1.32624826
45MP0002752_abnormal_somatic_nervous1.31477924
46MP0003935_abnormal_craniofacial_develop1.30506132
47MP0002067_abnormal_sensory_capabilities1.29575712
48MP0001486_abnormal_startle_reflex1.29454326
49MP0001672_abnormal_embryogenesis/_devel1.26551145
50MP0005380_embryogenesis_phenotype1.26551145
51MP0009745_abnormal_behavioral_response1.26022023
52MP0002822_catalepsy1.25933767
53MP0003861_abnormal_nervous_system1.24316573
54MP0002085_abnormal_embryonic_tissue1.23049823
55MP0003942_abnormal_urinary_system1.23012709
56MP0000566_synostosis1.22515889
57MP0002088_abnormal_embryonic_growth/wei1.21648233
58MP0001968_abnormal_touch/_nociception1.20866782
59MP0003984_embryonic_growth_retardation1.20257127
60MP0002736_abnormal_nociception_after1.16503111
61MP0000350_abnormal_cell_proliferation1.14071938
62MP0002160_abnormal_reproductive_system1.13935228
63MP0003315_abnormal_perineum_morphology1.11768176
64MP0000428_abnormal_craniofacial_morphol1.11530597
65MP0004185_abnormal_adipocyte_glucose1.10990835
66MP0008789_abnormal_olfactory_epithelium1.10769243
67MP0002084_abnormal_developmental_patter1.10659748
68MP0000762_abnormal_tongue_morphology1.10624889
69MP0002086_abnormal_extraembryonic_tissu1.10565304
70MP0004270_analgesia1.10188123
71MP0001286_abnormal_eye_development1.09851046
72MP0009046_muscle_twitch1.09405951
73MP0000432_abnormal_head_morphology1.09366049
74MP0002064_seizures1.07132185
75MP0002653_abnormal_ependyma_morphology1.07125656
76MP0002735_abnormal_chemical_nociception1.06870435
77MP0003011_delayed_dark_adaptation1.06243945
78MP0005645_abnormal_hypothalamus_physiol1.06056842
79MP0001984_abnormal_olfaction1.05347878
80MP0003077_abnormal_cell_cycle1.04875044
81MP0003705_abnormal_hypodermis_morpholog1.03760809
82MP0000026_abnormal_inner_ear1.03270408
83MP0003755_abnormal_palate_morphology1.02183240
84MP0001502_abnormal_circadian_rhythm1.01040757
85MP0001299_abnormal_eye_distance/0.98731974
86MP0005075_abnormal_melanosome_morpholog0.98077826
87MP0003646_muscle_fatigue0.97818895
88MP0002081_perinatal_lethality0.96144507
89MP0002396_abnormal_hematopoietic_system0.96050836
90MP0008770_decreased_survivor_rate0.94572103
91MP0003303_peritoneal_inflammation0.94358140
92MP0005623_abnormal_meninges_morphology0.94296584
93MP0002234_abnormal_pharynx_morphology0.94191768
94MP0003283_abnormal_digestive_organ0.93498413
95MP0002066_abnormal_motor_capabilities/c0.92648112
96MP0001905_abnormal_dopamine_level0.92477343
97MP0002233_abnormal_nose_morphology0.92141856
98MP0001970_abnormal_pain_threshold0.91668872
99MP0005551_abnormal_eye_electrophysiolog0.91101984
100MP0002249_abnormal_larynx_morphology0.89969621
101MP0000579_abnormal_nail_morphology0.89704997
102MP0002697_abnormal_eye_size0.89654051
103MP0002272_abnormal_nervous_system0.89325825
104MP0001849_ear_inflammation0.89290076
105MP0002006_tumorigenesis0.88648387
106MP0000631_abnormal_neuroendocrine_gland0.88404141
107MP0005076_abnormal_cell_differentiation0.87731774
108MP0005257_abnormal_intraocular_pressure0.87639883
109MP0002116_abnormal_craniofacial_bone0.87426215
110MP0004924_abnormal_behavior0.87366244
111MP0005386_behavior/neurological_phenoty0.87366244
112MP0010030_abnormal_orbit_morphology0.87150508
113MP0002932_abnormal_joint_morphology0.87131923
114MP0000534_abnormal_ureter_morphology0.86918189
115MP0002163_abnormal_gland_morphology0.86716423
116MP0005195_abnormal_posterior_eye0.86486073
117MP0002114_abnormal_axial_skeleton0.86144790
118MP0009250_abnormal_appendicular_skeleto0.86077367
119MP0004197_abnormal_fetal_growth/weight/0.85648266
120MP0001697_abnormal_embryo_size0.85405307
121MP0002733_abnormal_thermal_nociception0.85212013
122MP0002925_abnormal_cardiovascular_devel0.84089282
123MP0000537_abnormal_urethra_morphology0.83868595
124MP0008569_lethality_at_weaning0.83634175
125MP0002938_white_spotting0.83266808
126MP0008877_abnormal_DNA_methylation0.83211185
127MP0003111_abnormal_nucleus_morphology0.83146402
128MP0002184_abnormal_innervation0.82010351
129MP0003879_abnormal_hair_cell0.81988042
130MP0003137_abnormal_impulse_conducting0.81570138
131MP0004885_abnormal_endolymph0.80989321
132MP0005501_abnormal_skin_physiology0.80575136
133MP0002092_abnormal_eye_morphology0.80550738
134MP0002152_abnormal_brain_morphology0.80259888
135MP0002928_abnormal_bile_duct0.80080624
136MP0000703_abnormal_thymus_morphology0.79996483
137MP0002557_abnormal_social/conspecific_i0.79479738
138MP0002277_abnormal_respiratory_mucosa0.79433215
139MP0003567_abnormal_fetal_cardiomyocyte0.78784644
140MP0003763_abnormal_thymus_physiology0.77708334
141MP0001963_abnormal_hearing_physiology0.77611892
142MP0001293_anophthalmia0.77274614
143MP0003828_pulmonary_edema0.76417623
144MP0003385_abnormal_body_wall0.76314615
145MP0002127_abnormal_cardiovascular_syste0.75086289
146MP0002751_abnormal_autonomic_nervous0.74457479
147MP0005084_abnormal_gallbladder_morpholo0.73493859
148MP0002069_abnormal_eating/drinking_beha0.72945016
149MP0004883_abnormal_blood_vessel0.72742588
150MP0006276_abnormal_autonomic_nervous0.72480100
151MP0005646_abnormal_pituitary_gland0.70883629
152MP0008058_abnormal_DNA_repair0.68548049
153MP0002638_abnormal_pupillary_reflex0.68272664

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)6.16820792
2Myokymia (HP:0002411)4.50154180
3Bilateral microphthalmos (HP:0007633)4.45593705
4Focal seizures (HP:0007359)3.99079496
5Hypochromic microcytic anemia (HP:0004840)3.53254876
6Hyperventilation (HP:0002883)3.31172833
7Reticulocytopenia (HP:0001896)3.31025381
8Hepatoblastoma (HP:0002884)3.27267149
9Oligodactyly (hands) (HP:0001180)3.15201292
10Increased nuchal translucency (HP:0010880)3.13208540
11Ependymoma (HP:0002888)3.07932053
12Rib fusion (HP:0000902)2.98501345
13Abnormality of cells of the erythroid lineage (HP:0012130)2.97653795
14Neoplasm of striated muscle (HP:0009728)2.94509258
15Nephroblastoma (Wilms tumor) (HP:0002667)2.89909863
16Limb dystonia (HP:0002451)2.86511440
17Large earlobe (HP:0009748)2.82191613
18Cortical dysplasia (HP:0002539)2.73925119
19Septo-optic dysplasia (HP:0100842)2.69136951
20Abnormality of the lower motor neuron (HP:0002366)2.68888119
21Rhabdomyosarcoma (HP:0002859)2.67365336
22Embryonal renal neoplasm (HP:0011794)2.66364417
23Amyotrophic lateral sclerosis (HP:0007354)2.66291281
24Abnormality of the astrocytes (HP:0100707)2.66007582
25Astrocytoma (HP:0009592)2.66007582
26Amblyopia (HP:0000646)2.64508204
27Oligodactyly (HP:0012165)2.63088989
28Multiple enchondromatosis (HP:0005701)2.62057896
29Atresia of the external auditory canal (HP:0000413)2.60533327
30Abnormality of the aortic arch (HP:0012303)2.58717692
31Concave nail (HP:0001598)2.57093085
32Abnormal number of erythroid precursors (HP:0012131)2.54643729
33Supernumerary ribs (HP:0005815)2.54037290
34Diastasis recti (HP:0001540)2.52993370
35Abnormal hair whorl (HP:0010721)2.52261780
36Proximal placement of thumb (HP:0009623)2.51350287
37Agitation (HP:0000713)2.49204068
38Obsessive-compulsive behavior (HP:0000722)2.48877081
39Renal duplication (HP:0000075)2.45346174
40Myotonia (HP:0002486)2.43120290
41Anophthalmia (HP:0000528)2.43041934
42Hypochromic anemia (HP:0001931)2.38666337
43Abnormality of chromosome segregation (HP:0002916)2.38156768
44Partial duplication of thumb phalanx (HP:0009944)2.36126181
45Pachygyria (HP:0001302)2.33617036
46Symphalangism affecting the phalanges of the hand (HP:0009773)2.32541052
47Impulsivity (HP:0100710)2.32367900
48Hemivertebrae (HP:0002937)2.31820672
49Stenosis of the external auditory canal (HP:0000402)2.31094002
50Lissencephaly (HP:0001339)2.28245913
51Preauricular skin tag (HP:0000384)2.27581360
52Skin tags (HP:0010609)2.27218169
53Macrocytic anemia (HP:0001972)2.25834293
54Macroorchidism (HP:0000053)2.25790288
55High anterior hairline (HP:0009890)2.25721242
56Deviation of the thumb (HP:0009603)2.21773851
57Absent septum pellucidum (HP:0001331)2.21503676
58Supernumerary bones of the axial skeleton (HP:0009144)2.21238116
59Sleep apnea (HP:0010535)2.16749138
60Turricephaly (HP:0000262)2.14917800
61Epileptic encephalopathy (HP:0200134)2.12895411
62Patellar aplasia (HP:0006443)2.12592692
63Febrile seizures (HP:0002373)2.11297561
64Gait imbalance (HP:0002141)2.10460355
65Split foot (HP:0001839)2.09929418
66Focal motor seizures (HP:0011153)2.09165317
67Polyphagia (HP:0002591)2.08683450
68Excessive salivation (HP:0003781)2.08567685
69Drooling (HP:0002307)2.08567685
70Ankyloglossia (HP:0010296)2.08214754
71Truncal obesity (HP:0001956)2.07042525
72Congenital diaphragmatic hernia (HP:0000776)2.05380775
73Molar tooth sign on MRI (HP:0002419)2.04431683
74Abnormality of midbrain morphology (HP:0002418)2.04431683
75Medulloblastoma (HP:0002885)2.02747381
76Glioma (HP:0009733)2.02147209
77Aplasia/Hypoplasia of the patella (HP:0006498)2.00762721
78Generalized hypotonia (HP:0001290)1.98871196
79Esophageal atresia (HP:0002032)1.96337409
80Acute necrotizing encephalopathy (HP:0006965)1.93722584
81Abnormality of the phalanges of the hallux (HP:0010057)1.93442769
82Abnormality of the septum pellucidum (HP:0007375)1.91923452
83Inappropriate behavior (HP:0000719)1.91595214
84Abnormal number of incisors (HP:0011064)1.90613561
85Poor suck (HP:0002033)1.89613465
86Calf muscle hypertrophy (HP:0008981)1.87155571
87Embryonal neoplasm (HP:0002898)1.86953292
88Abnormality of the labia minora (HP:0012880)1.86895015
89Attention deficit hyperactivity disorder (HP:0007018)1.86541507
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.85989499
91Cutis marmorata (HP:0000965)1.85568009
92Malignant neoplasm of the central nervous system (HP:0100836)1.83974743
93Esotropia (HP:0000565)1.82833599
94Pancreatic fibrosis (HP:0100732)1.82826969
95Skin pits (HP:0100276)1.82775976
96Neoplasm of the heart (HP:0100544)1.82494800
97Horseshoe kidney (HP:0000085)1.81529747
98Periauricular skin pits (HP:0100277)1.81436762
99Preauricular pit (HP:0004467)1.81436762
100Pallor (HP:0000980)1.81116720
101Vertebral clefting (HP:0008428)1.81045461
102Hypoplasia of the radius (HP:0002984)1.80546113
103Pancreatic cysts (HP:0001737)1.79498356
104Testicular atrophy (HP:0000029)1.79328189
105Abnormality of the pubic bones (HP:0003172)1.79131531
106Horizontal nystagmus (HP:0000666)1.78614694
107Labial hypoplasia (HP:0000066)1.78335027
108Type II lissencephaly (HP:0007260)1.77432361
109Deep palmar crease (HP:0006191)1.77421802
110Hypogonadotrophic hypogonadism (HP:0000044)1.76922068
111Lipid accumulation in hepatocytes (HP:0006561)1.76888934
112Retinal dysplasia (HP:0007973)1.76867026
113Fetal akinesia sequence (HP:0001989)1.76580479
114Medial flaring of the eyebrow (HP:0010747)1.76539606
115Abnormality of the distal phalanx of the thumb (HP:0009617)1.76346682
116Short 4th metacarpal (HP:0010044)1.75039303
117Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75039303
118Depressed nasal ridge (HP:0000457)1.74799529
119Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74677657
120Muscle hypertrophy of the lower extremities (HP:0008968)1.74518433
121Megalencephaly (HP:0001355)1.74169298
122Synostosis involving the elbow (HP:0003938)1.74069143
123Humeroradial synostosis (HP:0003041)1.74069143
124Spastic tetraplegia (HP:0002510)1.73349716
125Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72619354
126Hypoplasia of the brainstem (HP:0002365)1.72619354
127Atonic seizures (HP:0010819)1.72184821
128Abnormality of the fingertips (HP:0001211)1.71042324
129Shawl scrotum (HP:0000049)1.70997879
130Blepharitis (HP:0000498)1.70751250
131Abnormality of the diencephalon (HP:0010662)1.69889203
132Smooth philtrum (HP:0000319)1.68298130
133Generalized tonic-clonic seizures (HP:0002069)1.68239983
134Anencephaly (HP:0002323)1.68137242
135Absent frontal sinuses (HP:0002688)1.67773459
136Dialeptic seizures (HP:0011146)1.67734912
137Increased hepatocellular lipid droplets (HP:0006565)1.67729361
138Achilles tendon contracture (HP:0001771)1.67424968
139Abnormality of the intervertebral disk (HP:0005108)1.66965441
140Duplication of thumb phalanx (HP:0009942)1.66453641
141Absence seizures (HP:0002121)1.66021992
142Neoplasm of the oral cavity (HP:0100649)1.65704692
143Abnormality of the parietal bone (HP:0002696)1.65175831
144Nephrogenic diabetes insipidus (HP:0009806)1.65061526
145Vaginal atresia (HP:0000148)1.64998093
146Partial duplication of the phalanx of hand (HP:0009999)1.64996644
147Heterotopia (HP:0002282)1.64987673
148Optic nerve hypoplasia (HP:0000609)1.64879239
149Failure to thrive in infancy (HP:0001531)1.64856074
150Mitochondrial inheritance (HP:0001427)1.64790301
151Low anterior hairline (HP:0000294)1.64301669
152Visual hallucinations (HP:0002367)1.64069141
153Abnormal pancreas size (HP:0012094)1.63816157
154Aplasia/hypoplasia of the humerus (HP:0006507)1.63502780
155Hip dysplasia (HP:0001385)1.63393736
156Hypoplastic female external genitalia (HP:0012815)1.63321181
157Autism (HP:0000717)1.63293633
158Prolonged QT interval (HP:0001657)1.63266823
159Prominent nose (HP:0000448)1.62121895
160Difficulty running (HP:0009046)1.62054092
161Short humerus (HP:0005792)1.61699647
162Gastroesophageal reflux (HP:0002020)1.61493486
163Genital tract atresia (HP:0001827)1.61463367
164Broad-based gait (HP:0002136)1.61359348
165Fused cervical vertebrae (HP:0002949)1.60629818
166Abnormality of the phalanges of the 5th finger (HP:0004213)1.60627046
167Abnormal lung lobation (HP:0002101)1.60481542
168Restlessness (HP:0000711)1.60242301
169Tented upper lip vermilion (HP:0010804)1.59663068
170Abnormality of the corticospinal tract (HP:0002492)1.59611523
171Chromsome breakage (HP:0040012)1.59037946
172Aplasia/Hypoplasia of the nipples (HP:0006709)1.58076196
173Renal cell carcinoma (HP:0005584)1.56691861
174Pendular nystagmus (HP:0012043)1.55975282
175Anomalous pulmonary venous return (HP:0010772)1.55638775
176Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.55630931
177Vesicoureteral reflux (HP:0000076)1.55402890
178Short palm (HP:0004279)1.54805669
179Abnormality of oral frenula (HP:0000190)1.54324297
180Chromosomal breakage induced by crosslinking agents (HP:0003221)1.53656978
181Apathy (HP:0000741)1.52879300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.02852150
2DMPK4.20248290
3NUAK13.69022554
4CASK3.37304324
5MAP3K73.05157292
6GRK52.93780226
7DYRK22.91105275
8GRK62.80631772
9STK162.56988597
10TAOK22.32088510
11TYRO32.29035761
12WNK32.16339903
13CAMK1D2.10034184
14SIK22.09154606
15RAF11.99760781
16STK38L1.86884065
17PIK3CA1.84864378
18TNIK1.82637402
19MAP3K101.74363692
20NTRK31.74346939
21PNCK1.70394892
22EPHA41.70021251
23CDC71.69323991
24MST41.66010303
25MAPK131.65723744
26STK381.64594687
27MAP2K41.58810684
28MARK21.56759542
29MAP3K41.48244692
30SGK4941.37395847
31SGK2231.37395847
32PRKCG1.36956242
33TAOK11.36273675
34ILK1.35544245
35TTK1.33769215
36WNK11.32650703
37BMPR1B1.31088424
38EPHB21.30072099
39PRPF4B1.29071685
40ALK1.26424487
41MAPKAPK51.23439848
42MAP3K91.19412809
43MARK11.19027634
44WNK41.18748948
45MAP3K121.17444525
46CSF1R1.15105783
47PRKD31.14895462
48CDK81.14855127
49TEC1.13226295
50VRK21.08159701
51MAPK71.07259177
52RIPK41.06749571
53NTRK21.06073437
54SGK21.05350071
55GRK71.04503695
56PRKD21.02524686
57LATS21.01292170
58DYRK31.00551065
59ADRBK20.98421583
60PAK30.98351255
61STK100.97962675
62CDK40.96879396
63KSR10.93345192
64CAMK40.92903857
65TAF10.92847403
66PHKG10.90711724
67PHKG20.90711724
68DYRK1B0.89725213
69GRK10.82941269
70HIPK20.81757689
71CDK70.80606857
72CHEK20.80495512
73PKN10.80403826
74CCNB10.79281960
75MATK0.77971557
76FES0.77093883
77DYRK1A0.75770626
78PRKCH0.75374445
79MKNK10.75164414
80TAOK30.74664005
81CSNK1E0.72381540
82NTRK10.72351613
83PAK60.70004946
84FGR0.68580169
85ROCK20.67381585
86SGK30.67117866
87SGK10.66811465
88CHEK10.66260414
89MINK10.65350927
90PLK40.65303628
91MAPK150.63618701
92PRKCZ0.62857629
93MAPK100.62181955
94ICK0.61965375
95MOS0.60598161
96FGFR30.60568320
97OBSCN0.60094007
98UHMK10.58115137
99ERBB20.57874497
100ATR0.57630479
101EEF2K0.56745532
102AURKA0.55305156
103RPS6KA20.55277541
104CAMK1G0.54915967
105PDGFRB0.54632274
106CDK20.53646386
107PDK10.53625764
108CDK30.53381852
109MKNK20.53102507
110MUSK0.52380348
111NME10.52078149
112TNK20.51770198
113STK110.51211753
114CSK0.50728865
115MAP2K70.50094187
116ADRBK10.48749267
117AKT10.48679706
118TGFBR20.48620559
119CDK190.48571499
120CDK11A0.47960104
121MTOR0.47690040
122PRKCQ0.47603994
123PINK10.46407436
124TLK10.45440021
125CDK150.45385539
126* CSNK2A20.44971354
127NEK20.44129178
128CSNK1G20.43773048
129CDK180.43091694
130CDK60.42891845
131DAPK10.42469963
132CSNK1D0.41998340
133MAPK120.41888449
134BRD40.41784591
135PAK40.41771781
136VRK10.41328300
137CDK50.40986873
138PLK10.40771979
139PDGFRA0.40101191
140RPS6KA30.39598888
141CDK140.39025770
142GSK3B0.38174419
143CDK90.38004577
144MAPK140.37768042
145CAMK2A0.37257922
146AKT20.36484290
147CDK10.36204432
148PRKACA0.36122719
149PLK20.34921907
150SRPK10.34853481
151* CSNK1A10.34675023
152MAP2K20.34488283
153PRKG10.32879252
154ATM0.31556621
155PRKDC0.30603106
156CAMK10.30378700

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.03074360
2Nicotine addiction_Homo sapiens_hsa050332.90148288
3Parkinsons disease_Homo sapiens_hsa050122.83598756
4Long-term potentiation_Homo sapiens_hsa047202.07557266
5Huntingtons disease_Homo sapiens_hsa050161.98701623
6Phototransduction_Homo sapiens_hsa047441.96857264
7Alzheimers disease_Homo sapiens_hsa050101.95963905
8Synaptic vesicle cycle_Homo sapiens_hsa047211.81337262
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68439601
10Glutamatergic synapse_Homo sapiens_hsa047241.62932736
11Adherens junction_Homo sapiens_hsa045201.57414104
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57326522
13Basal transcription factors_Homo sapiens_hsa030221.55290808
14Long-term depression_Homo sapiens_hsa047301.44679723
15Wnt signaling pathway_Homo sapiens_hsa043101.43466197
16T cell receptor signaling pathway_Homo sapiens_hsa046601.40669657
17Amphetamine addiction_Homo sapiens_hsa050311.35780225
18GnRH signaling pathway_Homo sapiens_hsa049121.34976569
19RNA polymerase_Homo sapiens_hsa030201.34781004
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34733286
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34191775
22Axon guidance_Homo sapiens_hsa043601.34100540
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33619286
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32441073
25Dopaminergic synapse_Homo sapiens_hsa047281.31619779
26Cholinergic synapse_Homo sapiens_hsa047251.30879708
27mTOR signaling pathway_Homo sapiens_hsa041501.30672542
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30456194
29Circadian entrainment_Homo sapiens_hsa047131.30170069
30Oxytocin signaling pathway_Homo sapiens_hsa049211.29114129
31Endometrial cancer_Homo sapiens_hsa052131.25885854
32mRNA surveillance pathway_Homo sapiens_hsa030151.25786124
33GABAergic synapse_Homo sapiens_hsa047271.24520646
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24503143
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24002291
36Base excision repair_Homo sapiens_hsa034101.23735384
37Choline metabolism in cancer_Homo sapiens_hsa052311.23326832
38Renin secretion_Homo sapiens_hsa049241.21975965
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20774848
40Ribosome_Homo sapiens_hsa030101.20230583
41ErbB signaling pathway_Homo sapiens_hsa040121.18672517
42Sulfur relay system_Homo sapiens_hsa041221.17925473
43Basal cell carcinoma_Homo sapiens_hsa052171.15639601
44Salivary secretion_Homo sapiens_hsa049701.14318307
45Morphine addiction_Homo sapiens_hsa050321.14232319
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13615378
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12993099
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12483150
49Serotonergic synapse_Homo sapiens_hsa047261.12384050
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11835604
51Glioma_Homo sapiens_hsa052141.11714298
52Insulin secretion_Homo sapiens_hsa049111.09516329
53VEGF signaling pathway_Homo sapiens_hsa043701.08869420
54Hippo signaling pathway_Homo sapiens_hsa043901.06852948
55Non-small cell lung cancer_Homo sapiens_hsa052231.05377882
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05017646
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04963812
58Mismatch repair_Homo sapiens_hsa034301.04689186
59Oocyte meiosis_Homo sapiens_hsa041141.04684218
60Melanogenesis_Homo sapiens_hsa049161.04495548
61MicroRNAs in cancer_Homo sapiens_hsa052061.03559186
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02781364
63Dorso-ventral axis formation_Homo sapiens_hsa043201.01958740
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01690231
65cAMP signaling pathway_Homo sapiens_hsa040241.01254303
66Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00406141
67Colorectal cancer_Homo sapiens_hsa052101.00184371
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.99209636
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.98706489
70Estrogen signaling pathway_Homo sapiens_hsa049150.98585251
71MAPK signaling pathway_Homo sapiens_hsa040100.98367272
72Rap1 signaling pathway_Homo sapiens_hsa040150.96635700
73Calcium signaling pathway_Homo sapiens_hsa040200.95156549
74Hedgehog signaling pathway_Homo sapiens_hsa043400.95126588
75Taste transduction_Homo sapiens_hsa047420.94914056
76Gastric acid secretion_Homo sapiens_hsa049710.92838425
77Thyroid cancer_Homo sapiens_hsa052160.92492599
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92096339
79Spliceosome_Homo sapiens_hsa030400.91572004
80Gap junction_Homo sapiens_hsa045400.90416338
81Tight junction_Homo sapiens_hsa045300.90141648
82RNA transport_Homo sapiens_hsa030130.89539632
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88473355
84Olfactory transduction_Homo sapiens_hsa047400.87670231
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87647583
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85944997
87Pathways in cancer_Homo sapiens_hsa052000.82510375
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82227220
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81805875
90Proteoglycans in cancer_Homo sapiens_hsa052050.81350145
91Cocaine addiction_Homo sapiens_hsa050300.81247484
92Cell cycle_Homo sapiens_hsa041100.80928656
93B cell receptor signaling pathway_Homo sapiens_hsa046620.80891685
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80333660
95Acute myeloid leukemia_Homo sapiens_hsa052210.79302432
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79064165
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78279579
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.77954909
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77447811
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77324453
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.76656560
102Ras signaling pathway_Homo sapiens_hsa040140.76397399
103Renal cell carcinoma_Homo sapiens_hsa052110.75774710
104Linoleic acid metabolism_Homo sapiens_hsa005910.74863910
105DNA replication_Homo sapiens_hsa030300.74704668
106Protein export_Homo sapiens_hsa030600.74029197
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72194862
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72097736
109African trypanosomiasis_Homo sapiens_hsa051430.71864686
110Platelet activation_Homo sapiens_hsa046110.69251549
111Cardiac muscle contraction_Homo sapiens_hsa042600.69224607
112Leishmaniasis_Homo sapiens_hsa051400.68470877
113Primary immunodeficiency_Homo sapiens_hsa053400.67391688
114Chronic myeloid leukemia_Homo sapiens_hsa052200.66109927
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.66101380
116Ether lipid metabolism_Homo sapiens_hsa005650.66100576
117Dilated cardiomyopathy_Homo sapiens_hsa054140.64734774
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64535822
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64444387
120Fanconi anemia pathway_Homo sapiens_hsa034600.64295845
121RNA degradation_Homo sapiens_hsa030180.63567323
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61649887
123Pancreatic cancer_Homo sapiens_hsa052120.61163868
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60531648
125Lysine degradation_Homo sapiens_hsa003100.60142735
126HTLV-I infection_Homo sapiens_hsa051660.60107593
127Notch signaling pathway_Homo sapiens_hsa043300.59823665
128Collecting duct acid secretion_Homo sapiens_hsa049660.59723396
129Nucleotide excision repair_Homo sapiens_hsa034200.59197783
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.56292167
131Selenocompound metabolism_Homo sapiens_hsa004500.53603801
132One carbon pool by folate_Homo sapiens_hsa006700.52919789
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51725362
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49677630
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46065857
136Homologous recombination_Homo sapiens_hsa034400.45650589
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43585729
138Melanoma_Homo sapiens_hsa052180.43383932
139Steroid biosynthesis_Homo sapiens_hsa001000.41755664
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39880319
141Pyrimidine metabolism_Homo sapiens_hsa002400.37380684
142Ovarian steroidogenesis_Homo sapiens_hsa049130.35684643

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