RTKN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.02085102
2central nervous system myelination (GO:0022010)9.02085102
3fatty acid elongation (GO:0030497)6.01049178
4ensheathment of neurons (GO:0007272)5.97239489
5axon ensheathment (GO:0008366)5.97239489
6myelination (GO:0042552)5.85073743
7desmosome organization (GO:0002934)4.90169388
8myelin maintenance (GO:0043217)4.69549593
9long-chain fatty acid biosynthetic process (GO:0042759)4.55136134
10regulation of cholesterol biosynthetic process (GO:0045540)4.38157531
11apical protein localization (GO:0045176)4.33171752
12negative regulation of fibrinolysis (GO:0051918)4.27172956
13protein carboxylation (GO:0018214)4.14233868
14peptidyl-glutamic acid carboxylation (GO:0017187)4.14233868
15oligodendrocyte differentiation (GO:0048709)4.08909162
16proline metabolic process (GO:0006560)4.06254525
17regulation of fibrinolysis (GO:0051917)4.05835017
18peptidyl-tyrosine autophosphorylation (GO:0038083)4.05796504
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.95834454
20L-phenylalanine metabolic process (GO:0006558)3.95834454
21regulation of cholesterol esterification (GO:0010872)3.75212582
22asymmetric protein localization (GO:0008105)3.74967891
23very-low-density lipoprotein particle assembly (GO:0034379)3.71598110
24bundle of His cell to Purkinje myocyte communication (GO:0086069)3.70190239
25protein retention in ER lumen (GO:0006621)3.68872479
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.65891692
27L-phenylalanine catabolic process (GO:0006559)3.65891692
28negative regulation of neurotransmitter secretion (GO:0046929)3.65507039
29regulation of protein activation cascade (GO:2000257)3.62440032
30astrocyte development (GO:0014002)3.59656486
31proline biosynthetic process (GO:0006561)3.57241950
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.55641432
33creatine metabolic process (GO:0006600)3.55340703
34negative regulation of neurotransmitter transport (GO:0051589)3.54453167
35regulation of complement activation (GO:0030449)3.51639973
36negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.50701710
37regulation of plasminogen activation (GO:0010755)3.50394262
38regulation of cholesterol homeostasis (GO:2000188)3.49712079
39myelination in peripheral nervous system (GO:0022011)3.48919559
40peripheral nervous system axon ensheathment (GO:0032292)3.48919559
41plasma lipoprotein particle assembly (GO:0034377)3.47917552
42cholesterol biosynthetic process (GO:0006695)3.47338477
43intestinal cholesterol absorption (GO:0030299)3.46911274
44photoreceptor cell differentiation (GO:0046530)3.46309854
45eye photoreceptor cell differentiation (GO:0001754)3.46309854
46adhesion of symbiont to host cell (GO:0044650)3.45915162
47virion attachment to host cell (GO:0019062)3.45915162
48establishment of mitochondrion localization (GO:0051654)3.45617632
49regulation of collateral sprouting (GO:0048670)3.38615288
50protein-lipid complex assembly (GO:0065005)3.34939589
51negative regulation of protein localization to cell surface (GO:2000009)3.34446608
52presynaptic membrane organization (GO:0097090)3.33943063
53long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.29494731
54neuronal action potential propagation (GO:0019227)3.29218707
55COPI coating of Golgi vesicle (GO:0048205)3.26589127
56Golgi transport vesicle coating (GO:0048200)3.26589127
57regulation of cholesterol metabolic process (GO:0090181)3.25099983
58regulation of apoptotic cell clearance (GO:2000425)3.22458244
59long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.14245744
60lung epithelium development (GO:0060428)3.11782915
61negative regulation of sterol transport (GO:0032372)3.10052437
62negative regulation of cholesterol transport (GO:0032375)3.10052437
63regulation of bile acid biosynthetic process (GO:0070857)3.09087916
64gap junction assembly (GO:0016264)3.08797228
65substantia nigra development (GO:0021762)3.07951936
66negative regulation of axonogenesis (GO:0050771)3.03512827
67protein-lipid complex remodeling (GO:0034368)3.03207140
68macromolecular complex remodeling (GO:0034367)3.03207140
69plasma lipoprotein particle remodeling (GO:0034369)3.03207140
70membrane tubulation (GO:0097320)3.03038416
71sterol biosynthetic process (GO:0016126)3.02349886
72presynaptic membrane assembly (GO:0097105)3.01706774
73glutamate metabolic process (GO:0006536)3.00634473
74iron coordination entity transport (GO:1901678)2.98364487
75glutamine family amino acid biosynthetic process (GO:0009084)2.97527401
76triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.96533361
77high-density lipoprotein particle remodeling (GO:0034375)2.96471554
78cholesterol efflux (GO:0033344)2.96247047
794-hydroxyproline metabolic process (GO:0019471)2.96022713
80sodium ion export (GO:0071436)2.94313559
81fatty-acyl-CoA biosynthetic process (GO:0046949)2.91531038
82L-amino acid import (GO:0043092)2.91475391
83cytoskeletal anchoring at plasma membrane (GO:0007016)2.89741484
84cell-substrate junction assembly (GO:0007044)2.88271903
85reverse cholesterol transport (GO:0043691)2.88112305
86synaptic vesicle maturation (GO:0016188)2.87511625
87dicarboxylic acid biosynthetic process (GO:0043650)2.86432239
88lateral sprouting from an epithelium (GO:0060601)2.86418814
89blood coagulation, intrinsic pathway (GO:0007597)2.85394140
90peripheral nervous system development (GO:0007422)2.84602809
91detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.84141757
92detection of temperature stimulus involved in sensory perception (GO:0050961)2.84141757
93phospholipid efflux (GO:0033700)2.82836425
94neuronal ion channel clustering (GO:0045161)2.82410337
95basement membrane organization (GO:0071711)2.82008482
96protein palmitoylation (GO:0018345)2.80511263
97low-density lipoprotein particle remodeling (GO:0034374)2.78666598
98fatty-acyl-CoA metabolic process (GO:0035337)2.77816995
99embryonic retina morphogenesis in camera-type eye (GO:0060059)2.74294310
100regulation of somitogenesis (GO:0014807)2.72947689
101fibrinolysis (GO:0042730)2.72754767
102neuron cell-cell adhesion (GO:0007158)2.72480884
103enteric nervous system development (GO:0048484)2.71279252
104cerebellar granule cell differentiation (GO:0021707)2.70553489
105transmission of nerve impulse (GO:0019226)2.70219363
106negative regulation of lipase activity (GO:0060192)2.69441948
107planar cell polarity pathway involved in neural tube closure (GO:0090179)2.68998763
108positive regulation of oligodendrocyte differentiation (GO:0048714)2.67775602
109retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.66712911
110protein localization to endosome (GO:0036010)2.66412957
111adult walking behavior (GO:0007628)2.65708858
112response to methylmercury (GO:0051597)2.62510284
113plasma lipoprotein particle organization (GO:0071827)2.62227082
114semaphorin-plexin signaling pathway (GO:0071526)2.61553035
115detection of temperature stimulus (GO:0016048)2.61040175
116renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.60343560
117protein-lipid complex subunit organization (GO:0071825)2.60341556
118cell-cell junction maintenance (GO:0045217)2.59360855
119heme transport (GO:0015886)2.59139305
120very long-chain fatty acid metabolic process (GO:0000038)2.58921748
121glycerophospholipid catabolic process (GO:0046475)2.58183466
122Leydig cell differentiation (GO:0033327)2.57829116
123negative regulation of axon extension (GO:0030517)2.55693771
124regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54866413
125urea metabolic process (GO:0019627)2.54636934
126regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.53166555
127limb bud formation (GO:0060174)2.53150429
128glutathione biosynthetic process (GO:0006750)2.52204240
129isoprenoid biosynthetic process (GO:0008299)2.50465822
130adhesion of symbiont to host (GO:0044406)2.50022515
131complement activation, alternative pathway (GO:0006957)2.49760041
132urea cycle (GO:0000050)2.49708060
133L-serine metabolic process (GO:0006563)2.49295895
134glutamate secretion (GO:0014047)2.47921071
135positive regulation of steroid metabolic process (GO:0045940)2.47152719
136positive regulation of cellular amine metabolic process (GO:0033240)2.46338971
137phosphate ion transmembrane transport (GO:0035435)2.45655061
138glycine transport (GO:0015816)2.45082676
139plasma lipoprotein particle clearance (GO:0034381)2.45077011
140negative regulation of catenin import into nucleus (GO:0035414)2.42645402
141amyloid precursor protein metabolic process (GO:0042982)2.42076024
142thioester biosynthetic process (GO:0035384)2.41102249
143acyl-CoA biosynthetic process (GO:0071616)2.41102249
144synaptic vesicle docking involved in exocytosis (GO:0016081)2.40545097
145adherens junction assembly (GO:0034333)2.40024663
146regulation of extracellular matrix disassembly (GO:0010715)2.39237208
147positive regulation of synapse maturation (GO:0090129)2.38972054
148regulation of extracellular matrix organization (GO:1903053)2.37558548
149cellular sodium ion homeostasis (GO:0006883)2.36993412
150purine nucleotide transport (GO:0015865)2.36885109
151axon development (GO:0061564)2.35373552
152cellular potassium ion homeostasis (GO:0030007)2.34904035
153substrate-independent telencephalic tangential migration (GO:0021826)2.34779875
154substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.34779875
155peptidyl-cysteine modification (GO:0018198)2.33531473
156response to redox state (GO:0051775)2.33207096
157hemidesmosome assembly (GO:0031581)2.33144109
158G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.32329952
159response to dietary excess (GO:0002021)2.31169266
160L-serine transport (GO:0015825)2.30469258
161cell-substrate adherens junction assembly (GO:0007045)2.29630724
162focal adhesion assembly (GO:0048041)2.29630724
163interleukin-6-mediated signaling pathway (GO:0070102)2.29139688
164positive regulation of neurological system process (GO:0031646)2.28660096
165neuron recognition (GO:0008038)2.28286869
166amino acid import (GO:0043090)2.27846622
167regulation of voltage-gated calcium channel activity (GO:1901385)2.27570801
168layer formation in cerebral cortex (GO:0021819)2.26703334
169regulation of myelination (GO:0031641)2.26595394
170neuron remodeling (GO:0016322)2.26477672
171negative regulation of blood coagulation (GO:0030195)2.25397719
172negative regulation of hemostasis (GO:1900047)2.25397719
173cell volume homeostasis (GO:0006884)2.25015823
174positive regulation of fatty acid biosynthetic process (GO:0045723)2.24935774
175synaptic vesicle exocytosis (GO:0016079)2.24704473
176positive regulation of action potential (GO:0045760)2.24333227
177nonribosomal peptide biosynthetic process (GO:0019184)2.23962525
178intestinal absorption (GO:0050892)2.23533524
179cellular modified amino acid catabolic process (GO:0042219)2.23458949
180membrane assembly (GO:0071709)2.23251012
181response to lead ion (GO:0010288)2.22466288
182negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.22394601
183negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.22135238
184cell migration in hindbrain (GO:0021535)2.21925097
185dendritic spine morphogenesis (GO:0060997)2.21337217
186negative regulation of lipid transport (GO:0032369)2.20332016
187neurotransmitter uptake (GO:0001504)2.19608405
188regulation of mammary gland epithelial cell proliferation (GO:0033599)2.19580048
189cerebral cortex radially oriented cell migration (GO:0021799)2.18980623
190positive regulation of pseudopodium assembly (GO:0031274)2.18952170
191nitrogen cycle metabolic process (GO:0071941)2.18594419
192positive regulation of triglyceride lipase activity (GO:0061365)2.17725890
193positive regulation of lipoprotein lipase activity (GO:0051006)2.17725890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.10767661
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85831667
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.74476280
4ZNF263_19887448_ChIP-Seq_K562_Human2.67157238
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.64463136
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61918974
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.59811914
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50364504
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44929952
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44929952
11LXR_22292898_ChIP-Seq_THP-1_Human2.39275910
12* RXR_22158963_ChIP-Seq_LIVER_Mouse2.34349228
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28364507
14GBX2_23144817_ChIP-Seq_PC3_Human2.27712188
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27030532
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21896080
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.19916589
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18595565
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.17046259
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.08470523
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.07946874
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05998156
23RACK7_27058665_Chip-Seq_MCF-7_Human2.03387982
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02956549
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01692826
26ESR1_15608294_ChIP-ChIP_MCF-7_Human2.01430626
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.98379529
28* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.98178074
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97443058
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.96794588
31CLOCK_20551151_ChIP-Seq_293T_Human1.95444512
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.88854939
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.87334478
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.83958363
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79379248
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.79317259
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.77415495
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76784518
39DROSHA_22980978_ChIP-Seq_HELA_Human1.71878134
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70545193
41EZH2_22144423_ChIP-Seq_EOC_Human1.66876615
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.66201871
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55935280
44* FOXA2_19822575_ChIP-Seq_HepG2_Human1.55094436
45AR_21572438_ChIP-Seq_LNCaP_Human1.54233932
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53829131
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53829131
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53829131
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.53555151
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50961780
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50160207
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.47143443
53STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.44925989
54* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44656817
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44065297
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.43974511
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43557444
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40498849
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36819783
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35692674
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35609217
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34646203
63SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34481933
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34473374
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34103610
66SMC4_20622854_ChIP-Seq_HELA_Human1.33544046
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32331017
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32219730
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30474423
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29850722
71* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29673493
72* TET1_21451524_ChIP-Seq_MESCs_Mouse1.28918131
73P68_20966046_ChIP-Seq_HELA_Human1.28837800
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28744087
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28435635
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27418719
77* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27206914
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26246012
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25992144
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.25669656
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24766035
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24736198
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.24556660
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24509032
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23570274
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23228811
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.23203116
88AHR_22903824_ChIP-Seq_MCF-7_Human1.22132023
89* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20736916
90ATF3_27146783_Chip-Seq_COLON_Human1.20253035
91AR_21909140_ChIP-Seq_LNCAP_Human1.19625464
92CREB1_26743006_Chip-Seq_LNCaP_Human1.18394573
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17350130
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16854421
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16161182
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15404194
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.15250502
98RUNX1_27514584_Chip-Seq_MCF-7_Human1.14949225
99REST_18959480_ChIP-ChIP_MESCs_Mouse1.14062014
100REST_21632747_ChIP-Seq_MESCs_Mouse1.13958640
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13795794
102POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12896023
103* TP53_22127205_ChIP-Seq_IMR90_Human1.11531591
104* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10911372
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10115299
106CBX2_27304074_Chip-Seq_ESCs_Mouse1.09319014
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09305811
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08622804
109EOMES_21245162_ChIP-Seq_HESCs_Human1.08338394
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.08294630
111TAF15_26573619_Chip-Seq_HEK293_Human1.08112436
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06384739
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05199342
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04957564
115EP300_21415370_ChIP-Seq_HL-1_Mouse1.04174599
116* CTCF_27219007_Chip-Seq_Bcells_Human1.04154608
117TP63_22573176_ChIP-Seq_HFKS_Human1.04057020
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04038583
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.03557910
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03237173
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02945347
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.02617454
123KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02455638
124* HNF4A_19822575_ChIP-Seq_HepG2_Human1.02110652
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01058464
126RARA_24833708_ChIP-Seq_LIVER_Mouse1.00928513
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00504161
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00368493
129FOXO3_23340844_ChIP-Seq_DLD1_Human1.00138914
130UBF1/2_26484160_Chip-Seq_HMECs_Human0.99915690
131ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99391653
132* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99196794
133WT1_19549856_ChIP-ChIP_CCG9911_Human0.99146062
134KDM2B_26808549_Chip-Seq_K562_Human0.98732776
135SMAD3_21741376_ChIP-Seq_EPCs_Human0.98126420
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96496068
137* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95818673
138CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95706870
139* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95159979
140TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95011831
141NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94877658
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94708867
143TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94604614
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93538245
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93538245
146NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92415457
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92219676
148P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92026085
149TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91915210
150SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90317291
151CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88727818
152* TET1_21490601_ChIP-Seq_MESCs_Mouse0.87761718
153SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.87307158
154ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87252972
155VDR_22108803_ChIP-Seq_LS180_Human0.86573488
156PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85901902
157KLF5_25053715_ChIP-Seq_YYC3_Human0.85491824
158CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84493266
159P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83781580
160ESR1_21235772_ChIP-Seq_MCF-7_Human0.82955486
161CDX2_20551321_ChIP-Seq_CACO-2_Human0.82521173
162STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81741381
163PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80045769
164SOX2_21211035_ChIP-Seq_LN229_Gbm0.79468436
165SMAD3_21741376_ChIP-Seq_HESCs_Human0.78911535
166SOX2_20726797_ChIP-Seq_SW620_Human0.78786861
167* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77796752
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.77068582
169GATA1_26923725_Chip-Seq_HPCs_Mouse0.76953747
170CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76626991
171SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74740434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.00737595
2MP0005171_absent_coat_pigmentation3.52172043
3MP0004270_analgesia3.42175184
4MP0003880_abnormal_central_pattern3.35623101
5MP0005360_urolithiasis3.26424160
6MP0004885_abnormal_endolymph3.17551043
7MP0002139_abnormal_hepatobiliary_system2.80343711
8MP0004859_abnormal_synaptic_plasticity2.64388680
9MP0003329_amyloid_beta_deposits2.40600759
10MP0003705_abnormal_hypodermis_morpholog2.39864607
11MP0003123_paternal_imprinting2.25835578
12MP0003122_maternal_imprinting2.23437143
13MP0004742_abnormal_vestibular_system2.19939986
14MP0002272_abnormal_nervous_system2.19497710
15MP0005365_abnormal_bile_salt2.18232286
16MP0003136_yellow_coat_color2.13404677
17MP0010678_abnormal_skin_adnexa2.07601016
18MP0002089_abnormal_postnatal_growth/wei2.06617349
19MP0002064_seizures2.04300839
20MP0001485_abnormal_pinna_reflex2.02082451
21MP0003690_abnormal_glial_cell1.99727510
22MP0003634_abnormal_glial_cell1.94898324
23MP0001666_abnormal_nutrient_absorption1.90401445
24MP0003635_abnormal_synaptic_transmissio1.88533309
25MP0005257_abnormal_intraocular_pressure1.87613206
26MP0003950_abnormal_plasma_membrane1.86648700
27MP0001486_abnormal_startle_reflex1.86321833
28MP0003566_abnormal_cell_adhesion1.80820995
29MP0004264_abnormal_extraembryonic_tissu1.79843334
30MP0003941_abnormal_skin_development1.77578158
31MP0004142_abnormal_muscle_tone1.75362687
32MP0002734_abnormal_mechanical_nocicepti1.74254589
33MP0009745_abnormal_behavioral_response1.73112539
34MP0000778_abnormal_nervous_system1.72632492
35MP0000762_abnormal_tongue_morphology1.71994701
36MP0000383_abnormal_hair_follicle1.71235784
37MP0000678_abnormal_parathyroid_gland1.65080499
38MP0004858_abnormal_nervous_system1.64853763
39MP0002822_catalepsy1.64251597
40MP0009046_muscle_twitch1.62629609
41MP0000462_abnormal_digestive_system1.62206791
42MP0000372_irregular_coat_pigmentation1.61326296
43MP0001529_abnormal_vocalization1.54288977
44MP0005623_abnormal_meninges_morphology1.52887020
45MP0000955_abnormal_spinal_cord1.52280076
46MP0010329_abnormal_lipoprotein_level1.48906389
47MP0004381_abnormal_hair_follicle1.48351326
48MP0002249_abnormal_larynx_morphology1.46911574
49MP0003632_abnormal_nervous_system1.45967212
50MP0009840_abnormal_foam_cell1.45188233
51MP0001968_abnormal_touch/_nociception1.44724929
52MP0005085_abnormal_gallbladder_physiolo1.43276651
53MP0000579_abnormal_nail_morphology1.43071880
54MP0002063_abnormal_learning/memory/cond1.41924652
55MP0001905_abnormal_dopamine_level1.36247230
56MP0004043_abnormal_pH_regulation1.35708631
57MP0000003_abnormal_adipose_tissue1.35067846
58MP0000747_muscle_weakness1.34705452
59MP0004272_abnormal_basement_membrane1.34224828
60MP0009053_abnormal_anal_canal1.31770296
61MP0002733_abnormal_thermal_nociception1.31429456
62MP0002572_abnormal_emotion/affect_behav1.31386233
63MP0003453_abnormal_keratinocyte_physiol1.29780336
64MP0000566_synostosis1.29746693
65MP0001970_abnormal_pain_threshold1.27885862
66MP0002796_impaired_skin_barrier1.27399189
67MP0000467_abnormal_esophagus_morphology1.26247508
68MP0002229_neurodegeneration1.25940421
69MP0008438_abnormal_cutaneous_collagen1.25037315
70MP0003879_abnormal_hair_cell1.24568971
71MP0002736_abnormal_nociception_after1.21690768
72MP0005058_abnormal_lysosome_morphology1.21361366
73MP0008260_abnormal_autophagy1.20643237
74MP0002882_abnormal_neuron_morphology1.19529127
75MP0002735_abnormal_chemical_nociception1.18526948
76MP0008569_lethality_at_weaning1.15291658
77MP0004019_abnormal_vitamin_homeostasis1.13866683
78MP0010030_abnormal_orbit_morphology1.12244691
79MP0002060_abnormal_skin_morphology1.12194527
80MP0002066_abnormal_motor_capabilities/c1.11620429
81MP0001849_ear_inflammation1.11550629
82MP0001346_abnormal_lacrimal_gland1.11450212
83MP0002067_abnormal_sensory_capabilities1.11072912
84MP0005408_hypopigmentation1.10782955
85MP0000537_abnormal_urethra_morphology1.10553598
86MP0001963_abnormal_hearing_physiology1.08188539
87MP0001915_intracranial_hemorrhage1.07510340
88MP0005023_abnormal_wound_healing1.06835864
89MP0005275_abnormal_skin_tensile1.06584478
90MP0001299_abnormal_eye_distance/1.06003489
91MP0004134_abnormal_chest_morphology1.05033103
92MP0003806_abnormal_nucleotide_metabolis1.05024108
93MP0001348_abnormal_lacrimal_gland1.04979767
94MP0005670_abnormal_white_adipose1.04857231
95MP0003631_nervous_system_phenotype1.04796098
96MP0000647_abnormal_sebaceous_gland1.04435612
97MP0001177_atelectasis1.03883029
98MP0002697_abnormal_eye_size1.03670022
99MP0010368_abnormal_lymphatic_system1.03571663
100MP0005501_abnormal_skin_physiology1.03126013
101MP0003938_abnormal_ear_development1.01837417
102MP0010234_abnormal_vibrissa_follicle1.01640549
103MP0001440_abnormal_grooming_behavior1.01345211
104MP0000534_abnormal_ureter_morphology1.00135520
105MP0003195_calcinosis0.99479852
106MP0005076_abnormal_cell_differentiation0.97356519
107MP0003115_abnormal_respiratory_system0.96955521
108MP0003868_abnormal_feces_composition0.94647236
109MP0002752_abnormal_somatic_nervous0.94309420
110MP0003183_abnormal_peptide_metabolism0.94201548
111MP0000377_abnormal_hair_follicle0.94197835
112MP0002909_abnormal_adrenal_gland0.93314145
113MP0000751_myopathy0.91827036
114MP0003385_abnormal_body_wall0.91583535
115MP0002184_abnormal_innervation0.91448464
116MP0002653_abnormal_ependyma_morphology0.90441443
117MP0003119_abnormal_digestive_system0.90392305
118MP0005423_abnormal_somatic_nervous0.89967562
119MP0001216_abnormal_epidermal_layer0.89440031
120MP0009384_cardiac_valve_regurgitation0.89405428
121MP0009250_abnormal_appendicular_skeleto0.88929223
122MP0003315_abnormal_perineum_morphology0.88737754
123MP0003633_abnormal_nervous_system0.88652115
124MP0002233_abnormal_nose_morphology0.86867075
125MP0002254_reproductive_system_inflammat0.85953244
126MP0008875_abnormal_xenobiotic_pharmacok0.85216817
127MP0003942_abnormal_urinary_system0.84880640
128MP0004145_abnormal_muscle_electrophysio0.83168607
129MP0005332_abnormal_amino_acid0.82715126
130MP0005410_abnormal_fertilization0.82479578
131MP0009780_abnormal_chondrocyte_physiolo0.82043318
132MP0005409_darkened_coat_color0.81653428
133MP0009672_abnormal_birth_weight0.80044809
134MP0002234_abnormal_pharynx_morphology0.79741648
135MP0010771_integument_phenotype0.79389365
136MP0002108_abnormal_muscle_morphology0.79250365
137MP0000026_abnormal_inner_ear0.78222697
138MP0004133_heterotaxia0.77393496
139MP0003283_abnormal_digestive_organ0.77354213
140MP0003937_abnormal_limbs/digits/tail_de0.77278469
141MP0002295_abnormal_pulmonary_circulatio0.76291938
142MP0000013_abnormal_adipose_tissue0.76035696
143MP0005451_abnormal_body_composition0.75944845
144MP0005377_hearing/vestibular/ear_phenot0.75735574
145MP0003878_abnormal_ear_physiology0.75735574
146MP0000604_amyloidosis0.74715176
147MP0002098_abnormal_vibrissa_morphology0.74270113
148MP0000749_muscle_degeneration0.74213755
149MP0001664_abnormal_digestion0.72740181
150MP0005375_adipose_tissue_phenotype0.72623777
151MP0001943_abnormal_respiration0.72603109
152MP0004924_abnormal_behavior0.72373373
153MP0001340_abnormal_eyelid_morphology0.70271114
154MP0002116_abnormal_craniofacial_bone0.69153147
155MP0002111_abnormal_tail_morphology0.69039531
156MP0002896_abnormal_bone_mineralization0.68745649
157MP0002118_abnormal_lipid_homeostasis0.67718331
158MP0001661_extended_life_span0.67007176
159MP0001270_distended_abdomen0.63073564
160MP0001730_embryonic_growth_arrest0.62872968
161MP0001502_abnormal_circadian_rhythm0.62106312
162MP0002938_white_spotting0.61442073

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.83069883
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.50809269
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.50809269
4Neurofibrillary tangles (HP:0002185)4.43485982
5Peripheral hypomyelination (HP:0007182)4.13501860
6Onion bulb formation (HP:0003383)3.92288279
7Sensory axonal neuropathy (HP:0003390)3.86859807
8Myokymia (HP:0002411)3.74091608
9Termporal pattern (HP:0011008)3.68066513
10Insidious onset (HP:0003587)3.68066513
11Abnormality of the corticospinal tract (HP:0002492)3.66272052
12Prolonged partial thromboplastin time (HP:0003645)3.56367982
13Parakeratosis (HP:0001036)3.47402307
14Cerebral inclusion bodies (HP:0100314)3.39213312
15Alacrima (HP:0000522)3.32700034
16Cerebral hypomyelination (HP:0006808)3.30870832
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.20166177
18Abnormal auditory evoked potentials (HP:0006958)3.19856677
19Right ventricular cardiomyopathy (HP:0011663)3.17455683
20Segmental peripheral demyelination/remyelination (HP:0003481)3.08570612
21Complement deficiency (HP:0004431)3.06010127
22Morphological abnormality of the inner ear (HP:0011390)2.98537833
23Fragile nails (HP:0001808)2.94829278
24Spastic gait (HP:0002064)2.94714106
25Hypobetalipoproteinemia (HP:0003563)2.93382138
26Ankle clonus (HP:0011448)2.93189741
27Abnormality of monocarboxylic acid metabolism (HP:0010996)2.88761039
28Supranuclear gaze palsy (HP:0000605)2.79490478
29Flat acetabular roof (HP:0003180)2.71826047
30Intention tremor (HP:0002080)2.70704335
31Hypercholesterolemia (HP:0003124)2.70049809
32Joint hemorrhage (HP:0005261)2.66906904
33Action tremor (HP:0002345)2.66652183
34Xanthomatosis (HP:0000991)2.65472061
35Ulnar claw (HP:0001178)2.63603450
36Foot dorsiflexor weakness (HP:0009027)2.59719541
37Esophageal atresia (HP:0002032)2.59316159
38Dysmetria (HP:0001310)2.57931750
39Coronal craniosynostosis (HP:0004440)2.57331125
40Aplasia involving bones of the upper limbs (HP:0009823)2.57180007
41Aplasia of the phalanges of the hand (HP:0009802)2.57180007
42Aplasia involving bones of the extremities (HP:0009825)2.57180007
43Hypokalemic alkalosis (HP:0001949)2.57082256
44Hyperacusis (HP:0010780)2.57007636
45Abnormality of complement system (HP:0005339)2.56062258
46Abnormality of glycolysis (HP:0004366)2.50346191
47Increased serum pyruvate (HP:0003542)2.50346191
48Decreased lacrimation (HP:0000633)2.46471983
49Scanning speech (HP:0002168)2.46332873
50Advanced eruption of teeth (HP:0006288)2.43799132
51Abnormality of carpal bone ossification (HP:0006257)2.43558550
52Hammertoe (HP:0001765)2.43365925
53Premature skin wrinkling (HP:0100678)2.42172030
54Stridor (HP:0010307)2.34629437
55Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.34172843
56Absent epiphyses (HP:0010577)2.34172843
57Plantar hyperkeratosis (HP:0007556)2.33202549
58Abnormality of the foot musculature (HP:0001436)2.31151292
59Hypoplastic pelvis (HP:0008839)2.29664616
60Small epiphyses (HP:0010585)2.28931372
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.27742202
62Hyporeflexia of lower limbs (HP:0002600)2.27089921
63Renal salt wasting (HP:0000127)2.26743104
64Abnormality of the Achilles tendon (HP:0005109)2.26227159
65Insomnia (HP:0100785)2.26027950
66Ulnar bowing (HP:0003031)2.25922752
67Hemorrhage of the eye (HP:0011885)2.25436579
68Hypoplasia of the iris (HP:0007676)2.25097467
69Abnormality of cochlea (HP:0000375)2.25017820
70Vascular calcification (HP:0004934)2.24261379
71Muscle fiber splitting (HP:0003555)2.23926498
72Focal motor seizures (HP:0011153)2.23915877
73Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.22109013
74Onycholysis (HP:0001806)2.21054252
75Abnormality of nail color (HP:0100643)2.19399983
76Megalencephaly (HP:0001355)2.16443300
77Split foot (HP:0001839)2.15688149
78Glomerulonephritis (HP:0000099)2.15393465
79Asymmetry of the thorax (HP:0001555)2.13752264
80Abnormality of the salivary glands (HP:0010286)2.13608821
81Pheochromocytoma (HP:0002666)2.13458599
82Congenital ichthyosiform erythroderma (HP:0007431)2.13396514
83Spastic paraparesis (HP:0002313)2.13360272
84Autoamputation (HP:0001218)2.12869822
85Distal sensory impairment (HP:0002936)2.12518485
86Akinesia (HP:0002304)2.12078282
87Metabolic alkalosis (HP:0200114)2.11825180
88Shallow orbits (HP:0000586)2.11406033
89Synostosis involving the elbow (HP:0003938)2.11316879
90Humeroradial synostosis (HP:0003041)2.11316879
91Distal upper limb amyotrophy (HP:0007149)2.10129474
92Upper limb amyotrophy (HP:0009129)2.10129474
93Atonic seizures (HP:0010819)2.09524029
94Steppage gait (HP:0003376)2.07375475
95Abnormality of the phalanges of the 2nd finger (HP:0009541)2.06685488
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.06509567
97Abnormality of the middle phalanges of the toes (HP:0010183)2.04619820
98Thickened helices (HP:0000391)2.04445475
99Decreased motor nerve conduction velocity (HP:0003431)2.04184458
100Hypolipoproteinemia (HP:0010981)2.02443155
101Partial duplication of thumb phalanx (HP:0009944)2.01678923
102Abnormal ossification of hand bones (HP:0005921)1.99528195
103Intrahepatic cholestasis (HP:0001406)1.99349509
104Difficulty running (HP:0009046)1.98671342
105Renal duplication (HP:0000075)1.98367167
106Turricephaly (HP:0000262)1.97158280
107Broad metatarsal (HP:0001783)1.95641465
108Bifid scrotum (HP:0000048)1.95465006
109Mitral stenosis (HP:0001718)1.94856343
110Pili torti (HP:0003777)1.94538333
111Lower limb muscle weakness (HP:0007340)1.93549359
112Slow saccadic eye movements (HP:0000514)1.93192795
113Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.93085365
114Natal tooth (HP:0000695)1.92089897
115Protrusio acetabuli (HP:0003179)1.91957533
116Back pain (HP:0003418)1.91119571
117Retinal dysplasia (HP:0007973)1.90961107
118Epiphyseal dysplasia (HP:0002656)1.90101679
119Cerebral aneurysm (HP:0004944)1.90096762
120Abnormal tarsal ossification (HP:0008369)1.89172175
121Cardiovascular calcification (HP:0011915)1.88415614
122Anteriorly placed anus (HP:0001545)1.88243109
123Abnormal hair laboratory examination (HP:0003328)1.86768299
124Infantile muscular hypotonia (HP:0008947)1.86435465
125Achilles tendon contracture (HP:0001771)1.85876734
126Increased circulating renin level (HP:0000848)1.85763113
127CNS hypomyelination (HP:0003429)1.85017628
128Systemic lupus erythematosus (HP:0002725)1.84654332
129Partial duplication of the phalanx of hand (HP:0009999)1.83788996
130Ileus (HP:0002595)1.83762921
131Axonal loss (HP:0003447)1.83477077
132Abnormal hand bone ossification (HP:0010660)1.82691767
133Hypomagnesemia (HP:0002917)1.81312516
134Neonatal death (HP:0003811)1.79785385
135Atrophic scars (HP:0001075)1.79496226
136Obstructive sleep apnea (HP:0002870)1.78728779
137Overriding aorta (HP:0002623)1.78726146
138Leukodystrophy (HP:0002415)1.78660298
139Alopecia of scalp (HP:0002293)1.78153233
140Pterygium (HP:0001059)1.77974217
141White forelock (HP:0002211)1.77837944
142Popliteal pterygium (HP:0009756)1.77297301
143Focal seizures (HP:0007359)1.76754672
144Bronchomalacia (HP:0002780)1.76682672
145Broad face (HP:0000283)1.75000596
146Abnormality of the lacrimal duct (HP:0011481)1.73563659
147Gowers sign (HP:0003391)1.72937250
148Absent septum pellucidum (HP:0001331)1.72902909
149Nasolacrimal duct obstruction (HP:0000579)1.72073648
150Hand muscle atrophy (HP:0009130)1.71703390
151Abnormality of the common coagulation pathway (HP:0010990)1.70794896
152Scapular winging (HP:0003691)1.70646587
153Premature rupture of membranes (HP:0001788)1.70533798
154Epileptic encephalopathy (HP:0200134)1.70066946
155Hyperaldosteronism (HP:0000859)1.69353592
156Spastic tetraparesis (HP:0001285)1.69144295
157Neuroendocrine neoplasm (HP:0100634)1.69002853
158Peripheral demyelination (HP:0011096)1.68854234
159Bell-shaped thorax (HP:0001591)1.68675578
160Choanal stenosis (HP:0000452)1.67796053
161Arnold-Chiari malformation (HP:0002308)1.67347593
162Renovascular hypertension (HP:0100817)1.66433001
163Fragile skin (HP:0001030)1.66408592
164Milia (HP:0001056)1.64035740
165Round ear (HP:0100830)1.63795431
166Hypoplasia of dental enamel (HP:0006297)1.62553566
167Ridged nail (HP:0001807)1.62248854
168Epidermoid cyst (HP:0200040)1.61572115
169Hypoalphalipoproteinemia (HP:0003233)1.61393230
170Cervical subluxation (HP:0003308)1.59732077
171Ankyloglossia (HP:0010296)1.59316998
172Neonatal short-limb short stature (HP:0008921)1.57533292
173Palmoplantar hyperkeratosis (HP:0000972)1.55609360
174Abnormality of pain sensation (HP:0010832)1.55324183
175Impaired pain sensation (HP:0007328)1.55324183
176Vertebral compression fractures (HP:0002953)1.54630769
177Hydroxyprolinuria (HP:0003080)1.54009499
178Abnormality of proline metabolism (HP:0010907)1.54009499
179Focal segmental glomerulosclerosis (HP:0000097)1.53304873
180Nail dystrophy (HP:0008404)1.53044414
181Lymphangioma (HP:0100764)1.51677999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.25091964
2OXSR13.91626013
3TRIB33.68099058
4FGFR43.45270919
5RIPK13.10317975
6EPHB13.02527240
7MET2.77701084
8SIK12.71579109
9BCR2.69872570
10CDK192.51184155
11WNK42.50656862
12SMG12.35558546
13NTRK12.26692330
14EPHA42.25098437
15PDGFRA2.21563752
16PRPF4B1.98680919
17FGFR21.93104680
18EEF2K1.92920146
19PKN11.92316089
20LATS21.92187943
21ICK1.91653846
22CDK121.89322084
23LIMK11.88082871
24TYRO31.86571935
25UHMK11.84537159
26WNK11.82385368
27CASK1.77761653
28MAPKAPK51.75671800
29DDR21.71961759
30ERN11.63386766
31PAK61.57835965
32CAMK2B1.49363525
33ROCK21.49107465
34KSR21.45116521
35PKN21.44265121
36CSNK1G31.41794233
37CSNK1A1L1.33539697
38FGR1.32981930
39LMTK21.32757918
40SGK2231.28858740
41SGK4941.28858740
42PAK41.24645073
43NEK61.21700996
44ARAF1.21667528
45FER1.19820061
46NME21.19605089
47MAP3K21.18877952
48FGFR31.18871015
49BMX1.17175013
50CAMK2D1.17124063
51MAP3K91.11951017
52CAMK2G1.11843593
53MST1R1.10255235
54CSNK1G21.09619428
55CSNK1G11.07144271
56PAK31.06683994
57MAPK151.04277336
58TESK11.02518982
59MTOR1.00857919
60MARK20.99383283
61PTK60.98691105
62CDK50.98621172
63CDK140.94682717
64DAPK20.93929453
65PRKD30.93350497
66FGFR10.92714394
67PIK3CA0.92680253
68IRAK30.89001413
69PBK0.88442947
70EPHB20.87767137
71CDK150.84890072
72PHKG10.84757777
73PHKG20.84757777
74CAMK2A0.84044710
75CDK180.83589069
76EPHA20.79933781
77NTRK30.79808576
78LATS10.78193117
79GRK50.77607102
80CDK11A0.75895643
81PRKD10.75724341
82TESK20.71670618
83PIM20.71203153
84MUSK0.70789612
85MST40.70475754
86PRKCE0.68508120
87MAP2K20.68129708
88PTK20.65900430
89DAPK30.62719773
90PDPK10.62695116
91PRKG20.62672259
92CDC42BPA0.62491015
93TRPM70.62434255
94DYRK1B0.62117484
95MAPKAPK30.60271896
96CAMK1D0.59301947
97MARK10.58933637
98PRKD20.58488943
99TNIK0.58012793
100AKT20.56960041
101ERBB40.56664479
102DYRK20.56196440
103PTK2B0.55870484
104BRSK10.55304154
105MINK10.53753654
106BRAF0.53467856
107MOS0.52708590
108PRKCI0.52494773
109CDK70.51403573
110STK380.50424529
111MAPK110.50275302
112NTRK20.49858026
113GSK3A0.49683534
114PRKCH0.49382137
115PNCK0.48676935
116PAK10.48560346
117FYN0.48250638
118MAPK70.47684242
119MATK0.47586764
120PRKCQ0.46315814
121RPS6KB20.45968461
122PDGFRB0.45509223
123CSNK1A10.45407262
124RPS6KA20.45360733
125MAP2K10.45287127
126ERBB20.44852335
127MAPK100.41867336
128ROCK10.41719070
129MAP3K10.40497823
130MAP3K70.39989930
131CAMK1G0.39790327
132KSR10.38835200
133PRKACB0.38721328
134STK38L0.38522328
135SGK30.38150096
136DAPK10.37625460
137ILK0.37486402
138PRKAA10.37432575
139ADRBK20.37225958
140RET0.36280504
141ALK0.35872280
142NME10.33533943
143CSNK1E0.33204308
144ADRBK10.31847271
145SRC0.30889959

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.68365473
2Fatty acid elongation_Homo sapiens_hsa000623.32648507
3Steroid biosynthesis_Homo sapiens_hsa001003.15567026
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.08656074
5Arginine biosynthesis_Homo sapiens_hsa002202.57832389
6Complement and coagulation cascades_Homo sapiens_hsa046102.55964313
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23843753
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.21856095
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19815094
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17532916
11Ether lipid metabolism_Homo sapiens_hsa005652.13504634
12Nitrogen metabolism_Homo sapiens_hsa009102.04210524
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01454235
14Biosynthesis of amino acids_Homo sapiens_hsa012301.94287850
15Axon guidance_Homo sapiens_hsa043601.91338047
16Phenylalanine metabolism_Homo sapiens_hsa003601.76602256
17Collecting duct acid secretion_Homo sapiens_hsa049661.71476983
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67503589
19Synaptic vesicle cycle_Homo sapiens_hsa047211.65656875
20Vibrio cholerae infection_Homo sapiens_hsa051101.62624105
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62348776
22Vitamin B6 metabolism_Homo sapiens_hsa007501.60650953
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57839993
24Sulfur relay system_Homo sapiens_hsa041221.55429864
25Fat digestion and absorption_Homo sapiens_hsa049751.48371030
26GABAergic synapse_Homo sapiens_hsa047271.48290427
27Sulfur metabolism_Homo sapiens_hsa009201.47457314
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46171798
29Tight junction_Homo sapiens_hsa045301.43553576
30Glutamatergic synapse_Homo sapiens_hsa047241.40370445
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38881476
32Fatty acid degradation_Homo sapiens_hsa000711.35252147
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28723284
34Salivary secretion_Homo sapiens_hsa049701.26802871
35Prion diseases_Homo sapiens_hsa050201.24890555
36Fructose and mannose metabolism_Homo sapiens_hsa000511.23386455
37Oxidative phosphorylation_Homo sapiens_hsa001901.22867533
38PPAR signaling pathway_Homo sapiens_hsa033201.22659135
39Other glycan degradation_Homo sapiens_hsa005111.21344486
40Histidine metabolism_Homo sapiens_hsa003401.19378776
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17156697
42Gastric acid secretion_Homo sapiens_hsa049711.16962707
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16868308
44Carbon metabolism_Homo sapiens_hsa012001.15377289
45Long-term depression_Homo sapiens_hsa047301.15103133
46Hedgehog signaling pathway_Homo sapiens_hsa043401.14715227
47Sphingolipid metabolism_Homo sapiens_hsa006001.13725270
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12835771
49Circadian entrainment_Homo sapiens_hsa047131.12515007
50Butanoate metabolism_Homo sapiens_hsa006501.12455681
51Olfactory transduction_Homo sapiens_hsa047401.11237952
52Serotonergic synapse_Homo sapiens_hsa047261.10956379
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.10922610
54Galactose metabolism_Homo sapiens_hsa000521.08612305
55Linoleic acid metabolism_Homo sapiens_hsa005911.08081445
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07254125
57ECM-receptor interaction_Homo sapiens_hsa045121.06587608
58Gap junction_Homo sapiens_hsa045401.05446460
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04561020
60Vitamin digestion and absorption_Homo sapiens_hsa049771.03680093
61Lysine degradation_Homo sapiens_hsa003101.03660739
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03228140
63Morphine addiction_Homo sapiens_hsa050321.03101640
64Cocaine addiction_Homo sapiens_hsa050301.03092049
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02707011
66Starch and sucrose metabolism_Homo sapiens_hsa005001.00983431
67Arginine and proline metabolism_Homo sapiens_hsa003300.99715911
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.98394667
69beta-Alanine metabolism_Homo sapiens_hsa004100.97471354
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.94935800
71Notch signaling pathway_Homo sapiens_hsa043300.92891188
72Retinol metabolism_Homo sapiens_hsa008300.89128238
73Melanogenesis_Homo sapiens_hsa049160.89045703
74Fatty acid biosynthesis_Homo sapiens_hsa000610.88427713
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.86457656
76Dopaminergic synapse_Homo sapiens_hsa047280.86395457
77ErbB signaling pathway_Homo sapiens_hsa040120.86110614
78Mineral absorption_Homo sapiens_hsa049780.85835990
79Nicotine addiction_Homo sapiens_hsa050330.85589187
80Amphetamine addiction_Homo sapiens_hsa050310.85322010
81Taste transduction_Homo sapiens_hsa047420.84976829
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.84913538
83Renal cell carcinoma_Homo sapiens_hsa052110.84497566
84Adherens junction_Homo sapiens_hsa045200.82902241
85Glucagon signaling pathway_Homo sapiens_hsa049220.82344338
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81283701
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80345729
88Alzheimers disease_Homo sapiens_hsa050100.79914170
89Fatty acid metabolism_Homo sapiens_hsa012120.79169695
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79080606
91Cholinergic synapse_Homo sapiens_hsa047250.77997286
92Endocytosis_Homo sapiens_hsa041440.77441029
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76903947
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.76833241
95Long-term potentiation_Homo sapiens_hsa047200.76370003
96Parkinsons disease_Homo sapiens_hsa050120.76015896
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75810984
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75808163
99Renin secretion_Homo sapiens_hsa049240.75088674
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75048081
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74578038
102Cardiac muscle contraction_Homo sapiens_hsa042600.74285452
103Pentose phosphate pathway_Homo sapiens_hsa000300.74084722
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73905756
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.72629377
106Basal cell carcinoma_Homo sapiens_hsa052170.71828583
107Protein digestion and absorption_Homo sapiens_hsa049740.70837896
108Ras signaling pathway_Homo sapiens_hsa040140.70532339
109AMPK signaling pathway_Homo sapiens_hsa041520.70348605
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70150398
111ABC transporters_Homo sapiens_hsa020100.69534013
112Hippo signaling pathway_Homo sapiens_hsa043900.69424667
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.68275014
114Focal adhesion_Homo sapiens_hsa045100.67442737
115Folate biosynthesis_Homo sapiens_hsa007900.67153976
116Pancreatic secretion_Homo sapiens_hsa049720.67111765
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66177747
118GnRH signaling pathway_Homo sapiens_hsa049120.66174548
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.65500846
120Bile secretion_Homo sapiens_hsa049760.65257600
121Insulin signaling pathway_Homo sapiens_hsa049100.65073849
122N-Glycan biosynthesis_Homo sapiens_hsa005100.64202583
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.63681241
124Propanoate metabolism_Homo sapiens_hsa006400.62563267
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.62492478
126Arachidonic acid metabolism_Homo sapiens_hsa005900.61893049
127Insulin secretion_Homo sapiens_hsa049110.61450684
128Chemical carcinogenesis_Homo sapiens_hsa052040.60479939
129Tyrosine metabolism_Homo sapiens_hsa003500.59735957
130Thyroid cancer_Homo sapiens_hsa052160.59237278
131Glutathione metabolism_Homo sapiens_hsa004800.58911378
132Oxytocin signaling pathway_Homo sapiens_hsa049210.58334379
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58207440
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57665023
135Dorso-ventral axis formation_Homo sapiens_hsa043200.57444440
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57375383
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56824303
138Pyruvate metabolism_Homo sapiens_hsa006200.55900452
139Calcium signaling pathway_Homo sapiens_hsa040200.55737766
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55150112
141Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53588862
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52810865
143Dilated cardiomyopathy_Homo sapiens_hsa054140.51729639
144Proteoglycans in cancer_Homo sapiens_hsa052050.50914241
145Rap1 signaling pathway_Homo sapiens_hsa040150.49925632
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49480249
147Glioma_Homo sapiens_hsa052140.49475782
148cAMP signaling pathway_Homo sapiens_hsa040240.49100337
149Endometrial cancer_Homo sapiens_hsa052130.47175527
150Wnt signaling pathway_Homo sapiens_hsa043100.46722568
151Thyroid hormone synthesis_Homo sapiens_hsa049180.46108763
152Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44980148
153Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44735246
154SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43206607
155Inositol phosphate metabolism_Homo sapiens_hsa005620.43149276
156Glycerolipid metabolism_Homo sapiens_hsa005610.42881593
157Bladder cancer_Homo sapiens_hsa052190.41117500
158Small cell lung cancer_Homo sapiens_hsa052220.40892712
159Renin-angiotensin system_Homo sapiens_hsa046140.39364085
160Peroxisome_Homo sapiens_hsa041460.36489575

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