RTKN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.99390556
2axon ensheathment in central nervous system (GO:0032291)6.99390556
3daunorubicin metabolic process (GO:0044597)6.30141243
4polyketide metabolic process (GO:0030638)6.30141243
5doxorubicin metabolic process (GO:0044598)6.30141243
6surfactant homeostasis (GO:0043129)5.26619981
7sister chromatid segregation (GO:0000819)5.14525167
8protein localization to kinetochore (GO:0034501)5.06995281
9mitotic sister chromatid segregation (GO:0000070)5.05517594
10sulfate transmembrane transport (GO:1902358)5.02020342
11DNA double-strand break processing (GO:0000729)4.99623190
12metaphase plate congression (GO:0051310)4.73193528
13mitotic metaphase plate congression (GO:0007080)4.72718113
14sulfate transport (GO:0008272)4.61428317
15auditory receptor cell stereocilium organization (GO:0060088)4.48707094
16sphingosine metabolic process (GO:0006670)4.40885050
17chemical homeostasis within a tissue (GO:0048875)4.40787462
18histone exchange (GO:0043486)4.38325160
19eye photoreceptor cell differentiation (GO:0001754)4.26709313
20photoreceptor cell differentiation (GO:0046530)4.26709313
21protein localization to chromosome, centromeric region (GO:0071459)4.21954524
22cellular anion homeostasis (GO:0030002)4.19598602
23response to redox state (GO:0051775)4.15168363
24kinetochore assembly (GO:0051382)4.13081672
25kinetochore organization (GO:0051383)4.10974667
26regulation of hippo signaling (GO:0035330)4.08645617
27DNA topological change (GO:0006265)4.00057731
28negative regulation of translation, ncRNA-mediated (GO:0040033)3.97154173
29regulation of translation, ncRNA-mediated (GO:0045974)3.97154173
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.97154173
31phosphate ion homeostasis (GO:0055062)3.96888293
32trivalent inorganic anion homeostasis (GO:0072506)3.96888293
33DNA replication-independent nucleosome assembly (GO:0006336)3.96080353
34DNA replication-independent nucleosome organization (GO:0034724)3.96080353
35replication fork processing (GO:0031297)3.95243121
36centriole assembly (GO:0098534)3.92400121
37microtubule polymerization or depolymerization (GO:0031109)3.92391387
38diol metabolic process (GO:0034311)3.91023358
39fatty acid elongation (GO:0030497)3.87953652
40myelin maintenance (GO:0043217)3.87913018
41sphingoid metabolic process (GO:0046519)3.87222958
42spindle checkpoint (GO:0031577)3.86480493
43centriole replication (GO:0007099)3.86295298
44mitotic chromosome condensation (GO:0007076)3.83732570
45negative regulation of chromosome segregation (GO:0051985)3.79240324
46negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.76141334
47negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.76141334
48negative regulation of mitotic sister chromatid segregation (GO:0033048)3.76141334
49negative regulation of mitotic sister chromatid separation (GO:2000816)3.76141334
50negative regulation of sister chromatid segregation (GO:0033046)3.76141334
51cellular response to gamma radiation (GO:0071480)3.75489519
52regulation of gene silencing by RNA (GO:0060966)3.75254709
53regulation of posttranscriptional gene silencing (GO:0060147)3.75254709
54regulation of gene silencing by miRNA (GO:0060964)3.75254709
55negative regulation of DNA-dependent DNA replication (GO:2000104)3.74380672
56aminoglycoside antibiotic metabolic process (GO:0030647)3.72729965
57establishment of chromosome localization (GO:0051303)3.71150567
58lymphangiogenesis (GO:0001946)3.70667174
59negative regulation of DNA recombination (GO:0045910)3.69459614
60regulation of mitotic metaphase/anaphase transition (GO:0030071)3.65964493
61regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.65964493
62regulation of mitotic sister chromatid separation (GO:0010965)3.64162058
63regulation of mitotic sister chromatid segregation (GO:0033047)3.64162058
64regulation of sister chromatid segregation (GO:0033045)3.64162058
65myelination (GO:0042552)3.63315224
66regulation of chromosome segregation (GO:0051983)3.63233495
67regulation of centriole replication (GO:0046599)3.62330252
68DNA ligation (GO:0006266)3.61412842
69mitotic spindle checkpoint (GO:0071174)3.61324666
70mitotic sister chromatid cohesion (GO:0007064)3.60304871
71ensheathment of neurons (GO:0007272)3.58245086
72axon ensheathment (GO:0008366)3.58245086
73positive regulation of oligodendrocyte differentiation (GO:0048714)3.51366193
74mitotic spindle assembly checkpoint (GO:0007094)3.48472443
75spindle assembly checkpoint (GO:0071173)3.45277680
76regulation of spindle organization (GO:0090224)3.42265253
77regulation of DNA endoreduplication (GO:0032875)3.38953983
78mitotic G2/M transition checkpoint (GO:0044818)3.36926367
79protein K6-linked ubiquitination (GO:0085020)3.36896522
80negative regulation of execution phase of apoptosis (GO:1900118)3.34639448
81microtubule depolymerization (GO:0007019)3.29713840
82chromosome segregation (GO:0007059)3.28860766
83energy homeostasis (GO:0097009)3.26282587
84cellular response to nitric oxide (GO:0071732)3.25951798
85regulation of centrosome cycle (GO:0046605)3.23982521
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.20065363
87DNA replication checkpoint (GO:0000076)3.19697676
88recombinational repair (GO:0000725)3.19683221
89histone-serine phosphorylation (GO:0035404)3.19665523
90regulation of mitotic spindle organization (GO:0060236)3.18247830
91mitotic recombination (GO:0006312)3.17791598
92inner ear receptor stereocilium organization (GO:0060122)3.16829670
93double-strand break repair via homologous recombination (GO:0000724)3.15632939
94meiotic chromosome segregation (GO:0045132)3.13825009
95positive regulation of neurological system process (GO:0031646)3.13632454
96limb bud formation (GO:0060174)3.13494941
97negative regulation of mitosis (GO:0045839)3.10931750
98centrosome organization (GO:0051297)3.10255732
99long-chain fatty acid biosynthetic process (GO:0042759)3.10234012
100positive regulation of endothelial cell differentiation (GO:0045603)3.09375822
101cerebral cortex radially oriented cell migration (GO:0021799)3.05454517
102prostate gland growth (GO:0060736)3.05306697
103non-recombinational repair (GO:0000726)3.05279736
104double-strand break repair via nonhomologous end joining (GO:0006303)3.05279736
105monoubiquitinated protein deubiquitination (GO:0035520)3.04785423
106telomere maintenance via semi-conservative replication (GO:0032201)3.04228170
107regulation of vasculogenesis (GO:2001212)3.04212216
108negative regulation of cell division (GO:0051782)3.04194953
109regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.03661233
110protein localization to chromosome (GO:0034502)3.01952327
111resolution of meiotic recombination intermediates (GO:0000712)3.00955671
112response to X-ray (GO:0010165)2.98698366
113ATP-dependent chromatin remodeling (GO:0043044)2.98694282
114positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98137249
115positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98137249
116positive regulation of mitotic sister chromatid separation (GO:1901970)2.98137249
117cornea development in camera-type eye (GO:0061303)2.96405058
118regulation of centrosome duplication (GO:0010824)2.95083289
119positive regulation of vasculogenesis (GO:2001214)2.95003620
120lateral ventricle development (GO:0021670)2.94905084
121DNA strand elongation involved in DNA replication (GO:0006271)2.94014048
122estrogen biosynthetic process (GO:0006703)2.92046663
123DNA integration (GO:0015074)2.91847382
124microtubule organizing center organization (GO:0031023)2.90915021
125chromosome condensation (GO:0030261)2.90729675
126negative regulation of macroautophagy (GO:0016242)2.89956847
127regulation of exit from mitosis (GO:0007096)2.89924436
128negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.89466892
129spindle assembly involved in mitosis (GO:0090307)2.88220602
130telomere maintenance via recombination (GO:0000722)2.86384267
131regulation of sister chromatid cohesion (GO:0007063)2.86333834
132cellular response to ionizing radiation (GO:0071479)2.86176777
133peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.84335601
134ER overload response (GO:0006983)2.84220831
135negative regulation of nuclear division (GO:0051784)2.83812684
136positive regulation of chromosome segregation (GO:0051984)2.83696398
137somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83500847
138somatic hypermutation of immunoglobulin genes (GO:0016446)2.83500847
139DNA strand elongation (GO:0022616)2.79522289
140induction of positive chemotaxis (GO:0050930)2.77549768
141establishment of integrated proviral latency (GO:0075713)2.77235977
142preassembly of GPI anchor in ER membrane (GO:0016254)2.76350027
143negative regulation of protein localization to cell surface (GO:2000009)2.76313626
144tight junction assembly (GO:0070830)2.74331032
145ganglion development (GO:0061548)2.69576167
146regulation of somitogenesis (GO:0014807)2.68016492
147DNA methylation involved in gamete generation (GO:0043046)2.67666628
148attachment of spindle microtubules to kinetochore (GO:0008608)2.65685751
149CENP-A containing nucleosome assembly (GO:0034080)2.63922065
150mesenchymal cell differentiation involved in kidney development (GO:0072161)2.61582659
151mesenchymal cell differentiation involved in renal system development (GO:2001012)2.61582659
152negative regulation of meiosis (GO:0045835)2.60867820
153detection of molecule of bacterial origin (GO:0032490)2.60473414
154negative regulation of mast cell activation (GO:0033004)2.59828770
155isoprenoid biosynthetic process (GO:0008299)2.59182642
156negative regulation of neurotransmitter transport (GO:0051589)2.59165778
157myelin assembly (GO:0032288)2.56784195
158regulation of mitotic spindle checkpoint (GO:1903504)2.56179182
159regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.56179182
160regulation of glomerular filtration (GO:0003093)2.56046928
161cholesterol biosynthetic process (GO:0006695)2.52189271
162regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.51030119
163GPI anchor biosynthetic process (GO:0006506)2.50956248
164negative regulation of glycogen biosynthetic process (GO:0045719)2.50911595
165negative regulation of skeletal muscle tissue development (GO:0048642)2.47550670
166regulation of integrin-mediated signaling pathway (GO:2001044)2.45385908
167regulation of pigment cell differentiation (GO:0050932)2.43198442
168mesodermal cell differentiation (GO:0048333)2.43108919
169glomerulus development (GO:0032835)2.42525746
170replicative senescence (GO:0090399)2.41304334
171positive regulation of cell cycle checkpoint (GO:1901978)2.40928881
172modulation by virus of host process (GO:0019054)2.40359183
173negative regulation of stem cell proliferation (GO:2000647)2.40348497
174negative regulation of axon extension involved in axon guidance (GO:0048843)2.39307525
175negative regulation of axon guidance (GO:1902668)2.39185831
176paraxial mesoderm development (GO:0048339)2.38867013
177chromatin remodeling at centromere (GO:0031055)2.38832376
178negative regulation of autophagy (GO:0010507)2.37923272
179negative regulation of myoblast differentiation (GO:0045662)2.36755939
180GPI anchor metabolic process (GO:0006505)2.36681299
181regulation of interleukin-13 production (GO:0032656)2.35970312
182histone H3-K9 modification (GO:0061647)2.32150342
183negative regulation of glycogen metabolic process (GO:0070874)2.29652024
184presynaptic membrane organization (GO:0097090)2.26917220

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.00356664
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.57900397
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.89841855
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.88242243
5GBX2_23144817_ChIP-Seq_PC3_Human2.78577701
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60782887
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59174406
8POU5F1_16153702_ChIP-ChIP_HESCs_Human2.39221798
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.30351831
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25637252
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21686429
12EWS_26573619_Chip-Seq_HEK293_Human2.14629839
13* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03664153
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02178040
15ZNF274_21170338_ChIP-Seq_K562_Hela1.96750224
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95254410
17IRF1_19129219_ChIP-ChIP_H3396_Human1.92156169
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91484241
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.89458251
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.89458251
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.89458251
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.89142887
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87132707
24IGF1R_20145208_ChIP-Seq_DFB_Human1.85900676
25EZH2_22144423_ChIP-Seq_EOC_Human1.80557474
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80506137
27VDR_22108803_ChIP-Seq_LS180_Human1.79868454
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.79300745
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.76801985
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.76607866
31FUS_26573619_Chip-Seq_HEK293_Human1.75826438
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74860973
33* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74505638
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.74223537
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73735455
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73458130
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71783994
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.70228702
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.68865612
40* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68523272
41* EZH2_27294783_Chip-Seq_NPCs_Mouse1.65161108
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64372423
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.64146032
44ELK1_19687146_ChIP-ChIP_HELA_Human1.61110582
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60718155
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59640254
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.57940983
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.57397850
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.56970924
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.56494458
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.54407851
52SUZ12_18555785_Chip-Seq_ESCs_Mouse1.52986553
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50881258
54STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.50860128
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48494427
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.45662757
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.45208691
58STAT3_18555785_Chip-Seq_ESCs_Mouse1.44616292
59P300_18555785_Chip-Seq_ESCs_Mouse1.44161034
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43944779
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.43529693
62P53_22387025_ChIP-Seq_ESCs_Mouse1.42589684
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42248810
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41721950
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40303741
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.39770902
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.39202306
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.37338717
69P300_19829295_ChIP-Seq_ESCs_Human1.37161716
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37084717
71LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36572471
72KLF4_18555785_Chip-Seq_ESCs_Mouse1.34410609
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.34331134
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.33372448
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.32729627
76RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29991790
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28988309
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28608075
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27947531
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27520766
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25832624
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25403338
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.24734291
84SMAD4_21799915_ChIP-Seq_A2780_Human1.24595825
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24525541
86RNF2_27304074_Chip-Seq_NSC_Mouse1.24351366
87OCT4_18555785_Chip-Seq_ESCs_Mouse1.23361801
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.23069763
89MYC_18940864_ChIP-ChIP_HL60_Human1.23059400
90* STAT3_23295773_ChIP-Seq_U87_Human1.22999264
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21741575
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21522271
93ER_23166858_ChIP-Seq_MCF-7_Human1.21246936
94ZFX_18555785_Chip-Seq_ESCs_Mouse1.20966853
95TAF15_26573619_Chip-Seq_HEK293_Human1.19618651
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19593670
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.17344917
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17075025
99PU1_27457419_Chip-Seq_LIVER_Mouse1.16682991
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13755187
101AR_21909140_ChIP-Seq_LNCAP_Human1.13165573
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12762377
103TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12584099
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.12529651
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.12394965
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.11388802
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.11011275
108TCF4_22108803_ChIP-Seq_LS180_Human1.10349985
109MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10345670
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10307789
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10307789
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10181877
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10177980
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10116585
115* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09850722
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07702462
117CBP_20019798_ChIP-Seq_JUKART_Human1.07702462
118AR_21572438_ChIP-Seq_LNCaP_Human1.06033997
119* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05727639
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05325399
121BCAT_22108803_ChIP-Seq_LS180_Human1.04956011
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.04403995
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02276702
124* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01253428
125AR_25329375_ChIP-Seq_VCAP_Human1.00873433
126TCF4_23295773_ChIP-Seq_U87_Human1.00578065
127NANOG_16153702_ChIP-ChIP_HESCs_Human1.00489293
128GATA2_21666600_ChIP-Seq_HMVEC_Human1.00180833
129RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99625411
130EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99625411
131CRX_20693478_ChIP-Seq_RETINA_Mouse0.99516177
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98872926
133NOTCH1_21737748_ChIP-Seq_TLL_Human0.98871250
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98731440
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98650946
136SOX9_26525672_Chip-Seq_HEART_Mouse0.98408702
137VDR_23849224_ChIP-Seq_CD4+_Human0.98318634
138RUNX2_22187159_ChIP-Seq_PCA_Human0.97598957
139SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96872058
140CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96617530
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95873055
142YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95700512
143SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94513651
144TCF4_18268006_ChIP-ChIP_LS174T_Human0.94124305
145* FOXP3_21729870_ChIP-Seq_TREG_Human0.93243066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog3.40860039
2MP0000566_synostosis3.31617322
3MP0006292_abnormal_olfactory_placode2.95950744
4MP0003950_abnormal_plasma_membrane2.86651016
5MP0000569_abnormal_digit_pigmentation2.63354789
6MP0001879_abnormal_lymphatic_vessel2.58165409
7MP0008995_early_reproductive_senescence2.52526582
8MP0001958_emphysema2.51525910
9MP0002277_abnormal_respiratory_mucosa2.49184844
10MP0010368_abnormal_lymphatic_system2.35818817
11MP0003136_yellow_coat_color2.34939320
12MP0002132_abnormal_respiratory_system2.30287690
13MP0004957_abnormal_blastocyst_morpholog2.17693632
14MP0008004_abnormal_stomach_pH2.13198426
15MP0001188_hyperpigmentation2.09990104
16MP0005171_absent_coat_pigmentation2.03260489
17MP0003941_abnormal_skin_development2.01000401
18MP0001177_atelectasis1.98953840
19MP0000920_abnormal_myelination1.98385969
20MP0008058_abnormal_DNA_repair1.95287602
21MP0000015_abnormal_ear_pigmentation1.95053555
22MP0003937_abnormal_limbs/digits/tail_de1.90085388
23MP0005409_darkened_coat_color1.89679459
24MP0010030_abnormal_orbit_morphology1.78389788
25MP0000678_abnormal_parathyroid_gland1.78248870
26MP0002234_abnormal_pharynx_morphology1.73280362
27MP0008260_abnormal_autophagy1.70238749
28MP0010094_abnormal_chromosome_stability1.69968926
29MP0006054_spinal_hemorrhage1.68579440
30MP0002102_abnormal_ear_morphology1.65159718
31MP0005377_hearing/vestibular/ear_phenot1.63985290
32MP0003878_abnormal_ear_physiology1.63985290
33MP0004742_abnormal_vestibular_system1.57298346
34MP0005174_abnormal_tail_pigmentation1.54268971
35MP0001485_abnormal_pinna_reflex1.53089281
36MP0005388_respiratory_system_phenotype1.52493976
37MP0002133_abnormal_respiratory_system1.52493976
38MP0006072_abnormal_retinal_apoptosis1.50821783
39MP0005408_hypopigmentation1.50007504
40MP0002938_white_spotting1.49722487
41MP0001542_abnormal_bone_strength1.46044065
42MP0000383_abnormal_hair_follicle1.45177893
43MP0003879_abnormal_hair_cell1.38618060
44MP0003119_abnormal_digestive_system1.38306377
45MP0001293_anophthalmia1.36234802
46MP0001346_abnormal_lacrimal_gland1.35839286
47MP0004885_abnormal_endolymph1.35654300
48MP0004134_abnormal_chest_morphology1.30619819
49MP0003718_maternal_effect1.29139537
50MP0003786_premature_aging1.28064369
51MP0001986_abnormal_taste_sensitivity1.27816293
52MP0002697_abnormal_eye_size1.23297835
53MP0005248_abnormal_Harderian_gland1.22992598
54MP0002295_abnormal_pulmonary_circulatio1.22098796
55MP0005394_taste/olfaction_phenotype1.22066153
56MP0005499_abnormal_olfactory_system1.22066153
57MP0004133_heterotaxia1.19871039
58MP0002095_abnormal_skin_pigmentation1.19655779
59MP0010307_abnormal_tumor_latency1.17979227
60MP0003890_abnormal_embryonic-extraembry1.16930348
61MP0002085_abnormal_embryonic_tissue1.15492859
62MP0005423_abnormal_somatic_nervous1.14951836
63MP0002233_abnormal_nose_morphology1.14926475
64MP0003195_calcinosis1.14844648
65MP0003567_abnormal_fetal_cardiomyocyte1.12817235
66MP0002084_abnormal_developmental_patter1.12167007
67MP0002098_abnormal_vibrissa_morphology1.12096965
68MP0009053_abnormal_anal_canal1.11423987
69MP0000049_abnormal_middle_ear1.10486504
70MP0005551_abnormal_eye_electrophysiolog1.10180354
71MP0000778_abnormal_nervous_system1.07928099
72MP0000026_abnormal_inner_ear1.07728119
73MP0000428_abnormal_craniofacial_morphol1.06964232
74MP0005645_abnormal_hypothalamus_physiol1.06905959
75MP0008789_abnormal_olfactory_epithelium1.06549737
76MP0001145_abnormal_male_reproductive1.06206709
77MP0001963_abnormal_hearing_physiology1.05661789
78MP0000653_abnormal_sex_gland1.05650672
79MP0001929_abnormal_gametogenesis1.05468031
80MP0003787_abnormal_imprinting1.04847611
81MP0000427_abnormal_hair_cycle1.03465659
82MP0010352_gastrointestinal_tract_polyps1.02851456
83MP0008057_abnormal_DNA_replication1.02451917
84MP0000470_abnormal_stomach_morphology1.02216438
85MP0000537_abnormal_urethra_morphology1.01079408
86MP0005391_vision/eye_phenotype1.00830910
87MP0004883_abnormal_blood_vessel1.00756733
88MP0002009_preneoplasia1.00717872
89MP0002177_abnormal_outer_ear0.99154989
90MP0010678_abnormal_skin_adnexa0.98618009
91MP0001697_abnormal_embryo_size0.98354312
92MP0000372_irregular_coat_pigmentation0.96507547
93MP0002111_abnormal_tail_morphology0.94538978
94MP0003191_abnormal_cellular_cholesterol0.93816118
95MP0003077_abnormal_cell_cycle0.93503263
96MP0001486_abnormal_startle_reflex0.93338129
97MP0005380_embryogenesis_phenotype0.92913783
98MP0001672_abnormal_embryogenesis/_devel0.92913783
99MP0003121_genomic_imprinting0.92616899
100MP0002653_abnormal_ependyma_morphology0.92244663
101MP0010386_abnormal_urinary_bladder0.92081336
102MP0000350_abnormal_cell_proliferation0.91971737
103MP0003115_abnormal_respiratory_system0.90928618
104MP0004043_abnormal_pH_regulation0.90692939
105MP0001175_abnormal_lung_morphology0.90622940
106MP0008932_abnormal_embryonic_tissue0.90059754
107MP0000762_abnormal_tongue_morphology0.89666100
108MP0000647_abnormal_sebaceous_gland0.89396764
109MP0009379_abnormal_foot_pigmentation0.89129056
110MP0005195_abnormal_posterior_eye0.88994889
111MP0001348_abnormal_lacrimal_gland0.88890080
112MP0009703_decreased_birth_body0.88365147
113MP0005395_other_phenotype0.87484096
114MP0001501_abnormal_sleep_pattern0.86058395
115MP0004197_abnormal_fetal_growth/weight/0.86034761
116MP0008877_abnormal_DNA_methylation0.85894384
117MP0003698_abnormal_male_reproductive0.85450578
118MP0001730_embryonic_growth_arrest0.85377330
119MP0004272_abnormal_basement_membrane0.85190355
120MP0003861_abnormal_nervous_system0.84677938
121MP0003111_abnormal_nucleus_morphology0.84036038
122MP0001286_abnormal_eye_development0.82876722
123MP0000462_abnormal_digestive_system0.82872438
124MP0000681_abnormal_thyroid_gland0.82273029
125MP0001119_abnormal_female_reproductive0.82182018
126MP0000631_abnormal_neuroendocrine_gland0.80899025
127MP0000432_abnormal_head_morphology0.80194481
128MP0000579_abnormal_nail_morphology0.77622572
129MP0003938_abnormal_ear_development0.77453984
130MP0002249_abnormal_larynx_morphology0.77300965
131MP0001529_abnormal_vocalization0.76180193
132MP0002088_abnormal_embryonic_growth/wei0.75049455
133MP0001186_pigmentation_phenotype0.74865603
134MP0004381_abnormal_hair_follicle0.74743753
135MP0002736_abnormal_nociception_after0.74258181
136MP0003984_embryonic_growth_retardation0.73337236
137MP0002092_abnormal_eye_morphology0.71968012
138MP0009697_abnormal_copulation0.71082701
139MP0002751_abnormal_autonomic_nervous0.70707244
140MP0002210_abnormal_sex_determination0.70096937
141MP0008007_abnormal_cellular_replicative0.69814062
142MP0005075_abnormal_melanosome_morpholog0.69017037
143MP0001851_eye_inflammation0.68156875
144MP0003755_abnormal_palate_morphology0.67832906
145MP0005164_abnormal_response_to0.67110195
146MP0005253_abnormal_eye_physiology0.66797337
147MP0003693_abnormal_embryo_hatching0.65428150
148MP0002752_abnormal_somatic_nervous0.63797783

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.44134125
2Chromsome breakage (HP:0040012)4.86549748
3Hyperactive renin-angiotensin system (HP:0000841)4.85183029
4Duplicated collecting system (HP:0000081)4.82276918
5Parakeratosis (HP:0001036)4.53943812
6Abnormality of the renal collecting system (HP:0004742)4.53670790
7Abnormality of the labia minora (HP:0012880)3.49628137
8Intestinal atresia (HP:0011100)3.44826268
9Volvulus (HP:0002580)3.43960894
10Colon cancer (HP:0003003)3.28584552
11Duplication of thumb phalanx (HP:0009942)3.10389626
12Chronic bronchitis (HP:0004469)3.08692455
13Absent eyebrow (HP:0002223)3.07046635
14Hyperkalemia (HP:0002153)3.06445852
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.94243662
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.92061270
17Degeneration of the lateral corticospinal tracts (HP:0002314)2.92061270
18Hyperaldosteronism (HP:0000859)2.91011671
19Meckel diverticulum (HP:0002245)2.86951780
20Sloping forehead (HP:0000340)2.83357815
21Renal salt wasting (HP:0000127)2.80670527
22Abnormality of the ileum (HP:0001549)2.78499760
23Follicular hyperkeratosis (HP:0007502)2.75830917
24Cortical dysplasia (HP:0002539)2.75742668
25Septo-optic dysplasia (HP:0100842)2.74756748
26Absent septum pellucidum (HP:0001331)2.67579672
27Cheilitis (HP:0100825)2.65079805
28Absent eyelashes (HP:0000561)2.64250063
29Pancreatic fibrosis (HP:0100732)2.56474832
30Respiratory distress (HP:0002098)2.55919617
31Ectopic kidney (HP:0000086)2.53404007
32Aplasia involving forearm bones (HP:0009822)2.52861709
33Absent forearm bone (HP:0003953)2.52861709
34Abolished electroretinogram (ERG) (HP:0000550)2.52015931
35Embryonal renal neoplasm (HP:0011794)2.49770677
36Absent radius (HP:0003974)2.48222360
37Interstitial pulmonary disease (HP:0006530)2.47973937
38True hermaphroditism (HP:0010459)2.43947846
39Tubulointerstitial fibrosis (HP:0005576)2.43389709
40Abnormality of renin-angiotensin system (HP:0000847)2.43101288
41Abnormality of the septum pellucidum (HP:0007375)2.40035266
42Abnormality of the preputium (HP:0100587)2.37617784
43Cupped ear (HP:0000378)2.36642144
44Duodenal stenosis (HP:0100867)2.34872858
45Small intestinal stenosis (HP:0012848)2.34872858
46Molar tooth sign on MRI (HP:0002419)2.34173999
47Abnormality of midbrain morphology (HP:0002418)2.34173999
48Supernumerary spleens (HP:0009799)2.31407013
49Patellar aplasia (HP:0006443)2.29617133
50Abnormality of chromosome stability (HP:0003220)2.28803482
51Aplasia/Hypoplasia of the sternum (HP:0006714)2.27018945
52Absent/shortened dynein arms (HP:0200106)2.26475913
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.26475913
54J-shaped sella turcica (HP:0002680)2.25963794
55Abnormality of the fingertips (HP:0001211)2.25337942
56Decreased circulating renin level (HP:0003351)2.24711154
57Birth length less than 3rd percentile (HP:0003561)2.23783690
58Nephronophthisis (HP:0000090)2.22796695
59Abnormality of the pulmonary veins (HP:0011718)2.22063909
60Short 4th metacarpal (HP:0010044)2.21537445
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21537445
62Abnormal lung lobation (HP:0002101)2.21405206
63Clubbing of toes (HP:0100760)2.20612955
64Osteomalacia (HP:0002749)2.19456224
65Gastrointestinal atresia (HP:0002589)2.17154180
66Prostate neoplasm (HP:0100787)2.17082823
67Patchy hypopigmentation of hair (HP:0011365)2.16769737
68Ependymoma (HP:0002888)2.14103370
69White forelock (HP:0002211)2.13985315
70Abnormality of the carotid arteries (HP:0005344)2.13048968
71Renal agenesis (HP:0000104)2.11567153
72Unilateral renal agenesis (HP:0000122)2.11442729
73Bifid tongue (HP:0010297)2.09462142
74Spontaneous hematomas (HP:0007420)2.08009980
75Blepharitis (HP:0000498)2.08000888
76Abnormality of the renal medulla (HP:0100957)2.07762102
77Glioma (HP:0009733)2.07175046
78Tubulointerstitial abnormality (HP:0001969)2.06491538
79Aplasia/Hypoplasia of the patella (HP:0006498)2.05901608
80Abnormality of the duodenum (HP:0002246)2.05321991
81Rhabdomyosarcoma (HP:0002859)2.02716106
82Pulmonary artery stenosis (HP:0004415)2.01603386
83Neoplasm of the tracheobronchial system (HP:0100552)1.99791177
84Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99610637
85Aplasia cutis congenita (HP:0001057)1.97102594
86Recurrent corneal erosions (HP:0000495)1.95961472
87Oligodactyly (hands) (HP:0001180)1.95435099
88Dandy-Walker malformation (HP:0001305)1.95202691
89Alveolar cell carcinoma (HP:0006519)1.94070744
90Arteriovenous malformation (HP:0100026)1.93985378
91Hyponatremia (HP:0002902)1.93379607
92Optic nerve hypoplasia (HP:0000609)1.92436344
93Renal hypoplasia (HP:0000089)1.92366941
94Preaxial foot polydactyly (HP:0001841)1.91963421
95Split foot (HP:0001839)1.91857314
96Aqueductal stenosis (HP:0002410)1.91605390
97Alacrima (HP:0000522)1.91455225
98Postaxial foot polydactyly (HP:0001830)1.91153063
99Bilateral microphthalmos (HP:0007633)1.90979451
100Myelodysplasia (HP:0002863)1.90852977
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89063866
102Exertional dyspnea (HP:0002875)1.88580592
103Mesomelia (HP:0003027)1.88420651
104Small hand (HP:0200055)1.88315606
105Neoplasm of the colon (HP:0100273)1.88134050
106Triphalangeal thumb (HP:0001199)1.88055057
107Abnormality of chloride homeostasis (HP:0011422)1.87878565
108Weak cry (HP:0001612)1.86057083
109Abnormality of the pons (HP:0007361)1.84649022
110Aplasia/Hypoplasia of the tibia (HP:0005772)1.83178876
111Cutaneous finger syndactyly (HP:0010554)1.82810721
112Genital tract atresia (HP:0001827)1.82457976
113Preaxial hand polydactyly (HP:0001177)1.81129124
114Hypokalemic alkalosis (HP:0001949)1.80543265
115Thickened helices (HP:0000391)1.79277983
116Astigmatism (HP:0000483)1.77692920
117Tubulointerstitial nephritis (HP:0001970)1.77431195
118Esophageal atresia (HP:0002032)1.77314429
119Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77248641
120Reticulocytopenia (HP:0001896)1.77090416
121Abnormality of the renal cortex (HP:0011035)1.77053578
122Increased nuchal translucency (HP:0010880)1.76593839
123Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76248191
124Vaginal atresia (HP:0000148)1.75433191
125Absent thumb (HP:0009777)1.75420917
126Medulloblastoma (HP:0002885)1.75403991
127Dyschromatopsia (HP:0007641)1.75065659
128Erythroderma (HP:0001019)1.74949726
129Short middle phalanx of the 5th finger (HP:0004220)1.74827858
130Oligodactyly (HP:0012165)1.74194012
131Chronic hepatic failure (HP:0100626)1.73766398
132Abnormality of chromosome segregation (HP:0002916)1.73085055
133Hypoplastic pelvis (HP:0008839)1.72989669
134Congenital sensorineural hearing impairment (HP:0008527)1.72590065
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.71622080
136Combined immunodeficiency (HP:0005387)1.71621536
137Astrocytoma (HP:0009592)1.71335502
138Abnormality of the astrocytes (HP:0100707)1.71335502
139Retinal dysplasia (HP:0007973)1.70663482
140Aplasia of the musculature (HP:0100854)1.70474815
141Segmental peripheral demyelination/remyelination (HP:0003481)1.69405319
142Adrenal hypoplasia (HP:0000835)1.69112473
143Neoplasm of the oral cavity (HP:0100649)1.69069165
144Abnormal ciliary motility (HP:0012262)1.69020315
145Abnormal auditory evoked potentials (HP:0006958)1.68431318
146Biliary tract neoplasm (HP:0100574)1.67620383
147Oligohydramnios (HP:0001562)1.67262996
148Ureteral duplication (HP:0000073)1.66727615
149Hyperphosphatemia (HP:0002905)1.66458907
150Holoprosencephaly (HP:0001360)1.66338661
151Midline defect of the nose (HP:0004122)1.65356702
152Abnormality of the 4th metacarpal (HP:0010012)1.65215380
153Rib fusion (HP:0000902)1.64821370
154Hypergonadotropic hypogonadism (HP:0000815)1.64709662
155Decreased lacrimation (HP:0000633)1.61868555
156Partial duplication of thumb phalanx (HP:0009944)1.61807922
157Coronal craniosynostosis (HP:0004440)1.61169991
158Pancreatic cysts (HP:0001737)1.60752278
159Nasolacrimal duct obstruction (HP:0000579)1.60274788
160Onycholysis (HP:0001806)1.59395056
161Tachypnea (HP:0002789)1.58803361
162Abnormal respiratory motile cilium morphology (HP:0005938)1.57177734
163Abnormal respiratory epithelium morphology (HP:0012253)1.57177734
164Ectropion (HP:0000656)1.56765546
165Chronic otitis media (HP:0000389)1.56396933
166Nephroblastoma (Wilms tumor) (HP:0002667)1.55498244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.50290842
2FRK3.38262025
3BRSK23.35124477
4EPHB12.98936364
5WEE12.94837562
6BUB12.73814145
7ICK2.63206026
8PLK42.60455614
9STK392.51730229
10NEK12.46983920
11YES12.46020611
12MKNK12.33753943
13PRPF4B2.02441272
14SIK31.99013038
15SRPK11.88712250
16AKT31.88556522
17EIF2AK21.83529856
18ZAK1.82848086
19MKNK21.78721973
20WNK31.78586467
21UHMK11.78332112
22MAP2K71.58527202
23CLK11.58447291
24PBK1.58066531
25PKN11.57850482
26TRIM281.57355065
27EPHB21.52102270
28MAPKAPK51.49225857
29ACVR1B1.43510321
30DYRK21.38998911
31SGK2231.38126645
32SGK4941.38126645
33MAP4K21.37244373
34BRD41.32853237
35TAF11.32804004
36PLK31.31166415
37VRK11.30942615
38MARK31.27980552
39BRAF1.27223210
40VRK21.26089049
41LATS11.24332618
42EPHA21.23116641
43WNK11.21768391
44EPHA31.20783866
45OXSR11.19998502
46EIF2AK31.19119270
47CDC71.13847347
48GRK11.13082901
49LIMK11.11204654
50BMPR1B1.08953880
51BCR1.06999586
52TXK1.03961134
53MARK20.98816345
54RPS6KA50.98436596
55NEK60.97105174
56TNIK0.96640301
57MET0.94676302
58NLK0.90679564
59PASK0.90003306
60TTK0.89220039
61NUAK10.89082846
62BMPR20.88811482
63STK160.85196961
64PLK10.84611193
65STK38L0.83903899
66STK40.83193032
67ERBB30.81030886
68NEK20.80892405
69TESK20.79863330
70CHEK20.79268672
71TGFBR20.78961220
72HIPK20.78129936
73MST40.78032757
74ADRBK20.77358913
75FGFR30.76675935
76MAPK130.75863189
77ATM0.75825405
78AURKB0.73625074
79CHEK10.73414099
80FGFR20.72007239
81STK100.70699134
82TSSK60.69980355
83IRAK10.69691748
84PLK20.67675015
85CSNK1A1L0.66528383
86SGK20.65536547
87TAOK30.64597257
88CDK80.64276313
89WNK40.63990690
90DYRK30.62974403
91FGR0.61505547
92PRKCE0.59753245
93INSRR0.58544349
94CASK0.57838501
95MUSK0.57777052
96CCNB10.57085124
97STK30.56404911
98PNCK0.56089863
99MELK0.55467408
100AURKA0.53527729
101CDK10.52662385
102CDK70.52003233
103PRKCQ0.50309327
104NME10.49980752
105ATR0.49524507
106MAPK150.48509956
107RPS6KL10.48128304
108RPS6KC10.48128304
109BRSK10.48108000
110RPS6KA60.48026567
111CDK30.46906779
112TLK10.46906142
113MAP3K100.46856606
114FGFR10.46543646
115TGFBR10.45947767
116TAOK20.45801584
117GSK3A0.45501778
118MAP3K40.43635609
119MAPKAPK20.43564158
120IRAK40.43274452
121RPS6KA40.43239447
122SIK10.43122439
123CSNK1G10.42767319
124CSK0.42470533
125TESK10.42293911
126PINK10.42109391
127GRK70.41841836
128CDK60.38491000
129CDK20.34791285
130CDK40.34580234
131CSNK2A10.33528206
132ERBB20.31858658
133CDK190.31266097
134EPHA40.28365192
135PRKACB0.27247845
136PRKDC0.25920876
137TEC0.25062319
138PRKCG0.24105913
139CSNK1D0.21873521

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.31496232
2Steroid biosynthesis_Homo sapiens_hsa001003.16267852
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.75657499
4Non-homologous end-joining_Homo sapiens_hsa034502.64871997
5Fatty acid elongation_Homo sapiens_hsa000622.61906068
6Homologous recombination_Homo sapiens_hsa034402.44281554
7DNA replication_Homo sapiens_hsa030302.42564387
8Fanconi anemia pathway_Homo sapiens_hsa034602.33467337
9Ether lipid metabolism_Homo sapiens_hsa005652.00981199
10Protein export_Homo sapiens_hsa030601.84294950
11Sphingolipid metabolism_Homo sapiens_hsa006001.78824335
12Mismatch repair_Homo sapiens_hsa034301.76228985
13Proteasome_Homo sapiens_hsa030501.62714162
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56438061
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55415870
16Cell cycle_Homo sapiens_hsa041101.54820859
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50020115
18Propanoate metabolism_Homo sapiens_hsa006401.45062836
19Histidine metabolism_Homo sapiens_hsa003401.42840958
20Oocyte meiosis_Homo sapiens_hsa041141.40603301
21Base excision repair_Homo sapiens_hsa034101.40095314
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.35838124
23Tight junction_Homo sapiens_hsa045301.35644998
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34972276
25Tryptophan metabolism_Homo sapiens_hsa003801.29584603
26Lysine degradation_Homo sapiens_hsa003101.28439494
27Basal transcription factors_Homo sapiens_hsa030221.27292948
28Axon guidance_Homo sapiens_hsa043601.22231433
29Basal cell carcinoma_Homo sapiens_hsa052171.19996270
30Spliceosome_Homo sapiens_hsa030401.19360457
31RNA polymerase_Homo sapiens_hsa030201.19295474
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16577024
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15191073
34Arachidonic acid metabolism_Homo sapiens_hsa005901.15078307
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14628117
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12711957
37Autoimmune thyroid disease_Homo sapiens_hsa053201.12673899
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10476155
39Ovarian steroidogenesis_Homo sapiens_hsa049131.09875925
40Hippo signaling pathway_Homo sapiens_hsa043901.08442422
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03631987
42Linoleic acid metabolism_Homo sapiens_hsa005911.03168899
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03044950
44MicroRNAs in cancer_Homo sapiens_hsa052061.02171393
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99629994
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99000531
47ECM-receptor interaction_Homo sapiens_hsa045120.95993170
48Vitamin B6 metabolism_Homo sapiens_hsa007500.95778170
49mRNA surveillance pathway_Homo sapiens_hsa030150.94961397
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90795158
51Notch signaling pathway_Homo sapiens_hsa043300.88097160
52Wnt signaling pathway_Homo sapiens_hsa043100.86775348
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86445404
54Circadian rhythm_Homo sapiens_hsa047100.86332856
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.85920774
56Mineral absorption_Homo sapiens_hsa049780.85103686
57RNA degradation_Homo sapiens_hsa030180.83556958
58Adherens junction_Homo sapiens_hsa045200.83081486
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83016870
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82919456
61Melanoma_Homo sapiens_hsa052180.82687315
62Nucleotide excision repair_Homo sapiens_hsa034200.82678536
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80946833
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.79183801
65Hedgehog signaling pathway_Homo sapiens_hsa043400.79151201
66Pancreatic cancer_Homo sapiens_hsa052120.78925575
67Pathways in cancer_Homo sapiens_hsa052000.78156868
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77935849
69Small cell lung cancer_Homo sapiens_hsa052220.76830684
70Taste transduction_Homo sapiens_hsa047420.76363627
71Sulfur metabolism_Homo sapiens_hsa009200.75831640
72Olfactory transduction_Homo sapiens_hsa047400.75663264
73Butanoate metabolism_Homo sapiens_hsa006500.74396410
74ABC transporters_Homo sapiens_hsa020100.73997462
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73867597
76Serotonergic synapse_Homo sapiens_hsa047260.71986212
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69703666
78Phototransduction_Homo sapiens_hsa047440.69479555
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68869982
80Prostate cancer_Homo sapiens_hsa052150.68301855
81Nicotine addiction_Homo sapiens_hsa050330.66576072
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66275826
83Systemic lupus erythematosus_Homo sapiens_hsa053220.65994969
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.65170476
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63353374
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.63154932
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.63120339
88Purine metabolism_Homo sapiens_hsa002300.62539812
89Arginine and proline metabolism_Homo sapiens_hsa003300.62338478
90Rap1 signaling pathway_Homo sapiens_hsa040150.62069079
91Ras signaling pathway_Homo sapiens_hsa040140.61284755
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61201032
93Fatty acid degradation_Homo sapiens_hsa000710.60234635
94Regulation of autophagy_Homo sapiens_hsa041400.59480239
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.59310094
96p53 signaling pathway_Homo sapiens_hsa041150.58955343
97Renal cell carcinoma_Homo sapiens_hsa052110.57321032
98Nitrogen metabolism_Homo sapiens_hsa009100.57092171
99Phagosome_Homo sapiens_hsa041450.56394918
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55837893
101beta-Alanine metabolism_Homo sapiens_hsa004100.54945213
102Pyrimidine metabolism_Homo sapiens_hsa002400.54838244
103RNA transport_Homo sapiens_hsa030130.54056885
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53763344
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.52365809
106Hematopoietic cell lineage_Homo sapiens_hsa046400.52172755
107Alcoholism_Homo sapiens_hsa050340.51949211
108Malaria_Homo sapiens_hsa051440.51373696
109HTLV-I infection_Homo sapiens_hsa051660.51340492
110One carbon pool by folate_Homo sapiens_hsa006700.51084076
111Retinol metabolism_Homo sapiens_hsa008300.49353278
112Huntingtons disease_Homo sapiens_hsa050160.48725419
113Pertussis_Homo sapiens_hsa051330.46738854
114Pyruvate metabolism_Homo sapiens_hsa006200.46143703
115Primary immunodeficiency_Homo sapiens_hsa053400.45114534
116Colorectal cancer_Homo sapiens_hsa052100.44733319
117Viral myocarditis_Homo sapiens_hsa054160.44156269
118Bladder cancer_Homo sapiens_hsa052190.43956461
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43353647
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43203607
121Asthma_Homo sapiens_hsa053100.41996039
122TGF-beta signaling pathway_Homo sapiens_hsa043500.41831362
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40601479
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40408230
125Selenocompound metabolism_Homo sapiens_hsa004500.40364244
126Allograft rejection_Homo sapiens_hsa053300.39799758
127Ribosome_Homo sapiens_hsa030100.39461560
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39413545
129Vitamin digestion and absorption_Homo sapiens_hsa049770.37390869
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28980461
131Glycerolipid metabolism_Homo sapiens_hsa005610.26536969
132Metabolic pathways_Homo sapiens_hsa011000.25138611
133Viral carcinogenesis_Homo sapiens_hsa052030.20699430
134FoxO signaling pathway_Homo sapiens_hsa040680.19498876
135Fatty acid metabolism_Homo sapiens_hsa012120.18312284
136Glutathione metabolism_Homo sapiens_hsa004800.15739511
137Morphine addiction_Homo sapiens_hsa050320.14391733
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.13933891

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