RTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.09123506
2synaptic vesicle maturation (GO:0016188)5.64156600
3synaptic vesicle exocytosis (GO:0016079)5.63988778
4vocalization behavior (GO:0071625)5.56716480
5neuron cell-cell adhesion (GO:0007158)5.41542369
6locomotory exploration behavior (GO:0035641)5.34265121
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.33046301
8glutamate secretion (GO:0014047)5.30670170
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.27066292
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.17270613
11regulation of synaptic vesicle exocytosis (GO:2000300)5.01505188
12protein localization to synapse (GO:0035418)4.92637456
13regulation of glutamate receptor signaling pathway (GO:1900449)4.87061879
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.61095144
15exploration behavior (GO:0035640)4.60362482
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.58843026
17nucleobase catabolic process (GO:0046113)4.54813378
18neurotransmitter secretion (GO:0007269)4.53643665
19regulation of synaptic vesicle transport (GO:1902803)4.49864124
20establishment of mitochondrion localization (GO:0051654)4.40511735
21layer formation in cerebral cortex (GO:0021819)4.38481877
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.21404813
23regulation of synapse structural plasticity (GO:0051823)4.20948807
24regulation of neuronal synaptic plasticity (GO:0048168)4.20693318
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.20380336
26neuron recognition (GO:0008038)4.15492028
27glutamate receptor signaling pathway (GO:0007215)4.14312389
28synaptic transmission, glutamatergic (GO:0035249)4.10183210
29neuronal action potential propagation (GO:0019227)4.09887885
30neurotransmitter-gated ion channel clustering (GO:0072578)3.98021687
31neuron-neuron synaptic transmission (GO:0007270)3.96768999
32positive regulation of synapse maturation (GO:0090129)3.90687316
33positive regulation of dendritic spine morphogenesis (GO:0061003)3.84204536
34dendritic spine morphogenesis (GO:0060997)3.81783777
35axonal fasciculation (GO:0007413)3.81761489
36proline transport (GO:0015824)3.77997211
37postsynaptic membrane organization (GO:0001941)3.72013723
38gamma-aminobutyric acid transport (GO:0015812)3.71529919
39neuronal ion channel clustering (GO:0045161)3.67871705
40neurotransmitter transport (GO:0006836)3.66554649
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.65277499
42long-term memory (GO:0007616)3.56772720
43synaptic vesicle endocytosis (GO:0048488)3.56073910
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55994201
45positive regulation of membrane potential (GO:0045838)3.54757945
46regulation of postsynaptic membrane potential (GO:0060078)3.53708643
47positive regulation of synapse assembly (GO:0051965)3.50788972
48sodium ion export (GO:0071436)3.50593762
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.49713316
50positive regulation of dendritic spine development (GO:0060999)3.49080737
51regulation of neurotransmitter levels (GO:0001505)3.46149458
52activation of protein kinase A activity (GO:0034199)3.44986299
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42447579
54regulation of neurotransmitter secretion (GO:0046928)3.41830027
55dendrite morphogenesis (GO:0048813)3.41158586
56regulation of synaptic plasticity (GO:0048167)3.41083129
57regulation of vesicle fusion (GO:0031338)3.40325170
58neurofilament cytoskeleton organization (GO:0060052)3.38949510
59presynaptic membrane assembly (GO:0097105)3.37840674
60transmission of nerve impulse (GO:0019226)3.37742554
61cell migration in hindbrain (GO:0021535)3.36857248
62auditory behavior (GO:0031223)3.36666716
63long-term synaptic potentiation (GO:0060291)3.35378251
64cellular potassium ion homeostasis (GO:0030007)3.34660803
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.34197862
66mitochondrion transport along microtubule (GO:0047497)3.34047235
67establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.34047235
68glycosphingolipid biosynthetic process (GO:0006688)3.32746356
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31687696
70synapse assembly (GO:0007416)3.28180174
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.27562288
72negative regulation of microtubule polymerization (GO:0031115)3.26546923
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25517959
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.24467495
75cerebellar Purkinje cell differentiation (GO:0021702)3.24346672
76regulation of dendritic spine morphogenesis (GO:0061001)3.23417758
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21967681
78response to auditory stimulus (GO:0010996)3.20616098
79pyrimidine nucleobase catabolic process (GO:0006208)3.20139407
80regulation of voltage-gated calcium channel activity (GO:1901385)3.19178244
81neuromuscular synaptic transmission (GO:0007274)3.18494332
82positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18274854
83positive regulation of neurotransmitter secretion (GO:0001956)3.17769949
84regulation of neurotransmitter transport (GO:0051588)3.17742171
85innervation (GO:0060384)3.16896137
86presynaptic membrane organization (GO:0097090)3.16316189
87synaptic vesicle transport (GO:0048489)3.15611170
88positive regulation of neurotransmitter transport (GO:0051590)3.15161739
89prepulse inhibition (GO:0060134)3.13986150
90response to histamine (GO:0034776)3.12333734
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12154436
92dendritic spine organization (GO:0097061)3.11566899
93regulation of dendritic spine development (GO:0060998)3.11285787
94regulation of synapse maturation (GO:0090128)3.10545642
95regulation of glutamate secretion (GO:0014048)3.09518086
96central nervous system projection neuron axonogenesis (GO:0021952)3.09254020
97behavioral defense response (GO:0002209)3.09089521
98behavioral fear response (GO:0001662)3.09089521
99mating behavior (GO:0007617)3.08936573
100membrane depolarization (GO:0051899)3.08817634
101learning (GO:0007612)3.06852232
102cerebellar granule cell differentiation (GO:0021707)3.06690062
103neuromuscular process controlling balance (GO:0050885)3.05524103
104neuromuscular process controlling posture (GO:0050884)3.04223815
105G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03958775
106adult walking behavior (GO:0007628)3.03783190
107cell communication by electrical coupling (GO:0010644)3.03243204
108cerebellar Purkinje cell layer development (GO:0021680)3.02537641
109social behavior (GO:0035176)3.01073743
110intraspecies interaction between organisms (GO:0051703)3.01073743
111membrane hyperpolarization (GO:0060081)3.00757630
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00571525
113acidic amino acid transport (GO:0015800)3.00156393
114mechanosensory behavior (GO:0007638)3.00144161
115cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99932401
116membrane depolarization during action potential (GO:0086010)2.99127135
117synaptic transmission (GO:0007268)2.99056250
118G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98928691
119fear response (GO:0042596)2.98279343
120response to pheromone (GO:0019236)2.98128688
121establishment of synaptic vesicle localization (GO:0097480)2.98085189
122synapse organization (GO:0050808)2.96657511
123regulation of synapse assembly (GO:0051963)2.94886781
124L-amino acid import (GO:0043092)2.93593000
125organelle transport along microtubule (GO:0072384)2.92624025
126establishment of vesicle localization (GO:0051650)2.91240532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.75188730
2* GBX2_23144817_ChIP-Seq_PC3_Human3.50078289
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18070843
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11159518
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04449656
6REST_21632747_ChIP-Seq_MESCs_Mouse2.84615763
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69896172
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69896172
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68122722
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65308587
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.61973760
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57985003
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57591305
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52227346
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51635502
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48019567
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.42340449
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31747476
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.31408776
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.31183413
21DROSHA_22980978_ChIP-Seq_HELA_Human2.30507482
22* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29395434
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.28568347
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.18753861
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11717517
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10820386
27TAF15_26573619_Chip-Seq_HEK293_Human2.04405629
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93108111
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90399076
30AR_21572438_ChIP-Seq_LNCaP_Human1.89902259
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84626935
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77958914
33* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66944682
34ZNF274_21170338_ChIP-Seq_K562_Hela1.62704371
35SMAD4_21799915_ChIP-Seq_A2780_Human1.61460517
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60226795
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54954777
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54570737
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.51421402
40IGF1R_20145208_ChIP-Seq_DFB_Human1.46790515
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45011818
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43605362
43* P300_19829295_ChIP-Seq_ESCs_Human1.41691024
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.39734367
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37801917
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.35751180
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34269110
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33184374
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32790012
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.30376965
51AR_25329375_ChIP-Seq_VCAP_Human1.28847933
52RNF2_27304074_Chip-Seq_NSC_Mouse1.28828677
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27888335
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.27446375
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27101400
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17454711
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16583931
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.16576296
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16380871
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15751594
61STAT3_23295773_ChIP-Seq_U87_Human1.15741488
62AR_19668381_ChIP-Seq_PC3_Human1.15646781
63* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14328657
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12908640
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.12323482
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.11343336
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07299863
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06730588
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05256408
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05027309
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.03918938
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03308515
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.03104058
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02476354
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01637673
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00997733
77* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00478467
78* TCF4_23295773_ChIP-Seq_U87_Human1.00460453
79AHR_22903824_ChIP-Seq_MCF-7_Human0.99736024
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99500729
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99500729
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98993192
83JUN_21703547_ChIP-Seq_K562_Human0.98954475
84* RUNX2_22187159_ChIP-Seq_PCA_Human0.98675742
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.98307668
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95325926
87NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95143537
88CBP_20019798_ChIP-Seq_JUKART_Human0.95070056
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95070056
90FUS_26573619_Chip-Seq_HEK293_Human0.94878162
91* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94840318
92* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94569928
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94238152
94* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94230049
95ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93917036
96* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93305394
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93267565
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92609566
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.92362959
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91990867
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91721450
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91110155
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.90296021
104KDM2B_26808549_Chip-Seq_K562_Human0.90071920
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89696463
106TAL1_26923725_Chip-Seq_HPCs_Mouse0.89625263
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88129848
108KDM2B_26808549_Chip-Seq_REH_Human0.85670580
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85604573
110SOX9_26525672_Chip-Seq_HEART_Mouse0.84975663
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84907691
112* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83214115
113BCAT_22108803_ChIP-Seq_LS180_Human0.82768470
114ER_23166858_ChIP-Seq_MCF-7_Human0.82742079
115VDR_22108803_ChIP-Seq_LS180_Human0.82577540
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81939547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.09144258
2MP0003880_abnormal_central_pattern5.02662090
3MP0003635_abnormal_synaptic_transmissio4.08864612
4MP0004270_analgesia3.62390853
5MP0009745_abnormal_behavioral_response3.35221329
6MP0002063_abnormal_learning/memory/cond3.33590241
7MP0005423_abnormal_somatic_nervous3.18202564
8MP0001968_abnormal_touch/_nociception3.07729329
9MP0002064_seizures3.05647712
10MP0009046_muscle_twitch2.92920964
11MP0002572_abnormal_emotion/affect_behav2.84570021
12MP0002734_abnormal_mechanical_nocicepti2.66268552
13MP0002822_catalepsy2.65815452
14MP0006276_abnormal_autonomic_nervous2.55379757
15MP0002272_abnormal_nervous_system2.46124465
16MP0002735_abnormal_chemical_nociception2.43082439
17MP0001486_abnormal_startle_reflex2.41601092
18MP0002736_abnormal_nociception_after2.38578645
19MP0001440_abnormal_grooming_behavior2.35462981
20MP0002733_abnormal_thermal_nociception2.26656254
21MP0001501_abnormal_sleep_pattern2.21905058
22MP0000778_abnormal_nervous_system2.13161039
23MP0002184_abnormal_innervation2.09512993
24MP0001970_abnormal_pain_threshold2.05830416
25MP0002067_abnormal_sensory_capabilities2.01191593
26MP0001984_abnormal_olfaction1.95456539
27MP0002557_abnormal_social/conspecific_i1.90606144
28MP0004924_abnormal_behavior1.86620569
29MP0005386_behavior/neurological_phenoty1.86620569
30MP0003122_maternal_imprinting1.83766868
31MP0004811_abnormal_neuron_physiology1.81955757
32MP0004858_abnormal_nervous_system1.80721465
33MP0003329_amyloid_beta_deposits1.78746018
34MP0001529_abnormal_vocalization1.75300090
35MP0001905_abnormal_dopamine_level1.70082268
36MP0005645_abnormal_hypothalamus_physiol1.66396137
37MP0008569_lethality_at_weaning1.64290860
38MP0002909_abnormal_adrenal_gland1.63524516
39MP0000955_abnormal_spinal_cord1.60156629
40MP0009780_abnormal_chondrocyte_physiolo1.55085780
41MP0005646_abnormal_pituitary_gland1.52877300
42MP0003787_abnormal_imprinting1.52572950
43MP0002882_abnormal_neuron_morphology1.47322017
44MP0003879_abnormal_hair_cell1.45394365
45MP0002066_abnormal_motor_capabilities/c1.42937561
46MP0004142_abnormal_muscle_tone1.38915935
47MP0001188_hyperpigmentation1.35466146
48MP0001502_abnormal_circadian_rhythm1.32344655
49MP0001986_abnormal_taste_sensitivity1.30666471
50MP0002102_abnormal_ear_morphology1.27275321
51MP0004885_abnormal_endolymph1.22885017
52MP0000569_abnormal_digit_pigmentation1.18226572
53MP0002152_abnormal_brain_morphology1.17655246
54MP0008877_abnormal_DNA_methylation1.16096202
55MP0003633_abnormal_nervous_system1.12749139
56MP0010386_abnormal_urinary_bladder1.07026147
57MP0000751_myopathy1.05293537
58MP0003631_nervous_system_phenotype1.02331573
59MP0003690_abnormal_glial_cell1.01370086
60MP0008872_abnormal_physiological_respon1.01309614
61MP0004742_abnormal_vestibular_system0.99670212
62MP0002069_abnormal_eating/drinking_beha0.97708231
63MP0005394_taste/olfaction_phenotype0.96647731
64MP0005499_abnormal_olfactory_system0.96647731
65MP0002229_neurodegeneration0.90954401
66MP0000920_abnormal_myelination0.88563331
67MP0002638_abnormal_pupillary_reflex0.88522815
68MP0002653_abnormal_ependyma_morphology0.87575413
69MP0000631_abnormal_neuroendocrine_gland0.87505406
70MP0002752_abnormal_somatic_nervous0.85400185
71MP0005535_abnormal_body_temperature0.85093833
72MP0004145_abnormal_muscle_electrophysio0.83040395
73MP0005551_abnormal_eye_electrophysiolog0.82919824
74MP0001963_abnormal_hearing_physiology0.80596625
75MP0008874_decreased_physiological_sensi0.78834352
76MP0004085_abnormal_heartbeat0.78465537
77MP0001177_atelectasis0.77857730
78MP0003634_abnormal_glial_cell0.77177236
79MP0002837_dystrophic_cardiac_calcinosis0.77010088
80MP0003632_abnormal_nervous_system0.76144475
81MP0000604_amyloidosis0.74808488
82MP0003123_paternal_imprinting0.74647896
83MP0008961_abnormal_basal_metabolism0.73248877
84MP0004147_increased_porphyrin_level0.71385391
85MP0003938_abnormal_ear_development0.70923356
86MP0004133_heterotaxia0.69924111
87MP0003121_genomic_imprinting0.69497318
88MP0003861_abnormal_nervous_system0.69129056
89MP0001664_abnormal_digestion0.67844636
90MP0002876_abnormal_thyroid_physiology0.65080779
91MP0005253_abnormal_eye_physiology0.64211464
92MP0005409_darkened_coat_color0.63399248
93MP0003137_abnormal_impulse_conducting0.62201037
94MP0002751_abnormal_autonomic_nervous0.61712342
95MP0008789_abnormal_olfactory_epithelium0.59442868
96MP0000013_abnormal_adipose_tissue0.59264075
97MP0004215_abnormal_myocardial_fiber0.58740371
98MP0001943_abnormal_respiration0.58239067
99MP0010770_preweaning_lethality0.55606436
100MP0002082_postnatal_lethality0.55606436
101MP0010769_abnormal_survival0.55515976
102MP0001299_abnormal_eye_distance/0.54460961
103MP0001485_abnormal_pinna_reflex0.54188796
104MP0002090_abnormal_vision0.53941989
105MP0004233_abnormal_muscle_weight0.52323457
106MP0010768_mortality/aging0.52249347
107MP0004043_abnormal_pH_regulation0.52199765
108MP0005187_abnormal_penis_morphology0.51539834
109MP0003956_abnormal_body_size0.51536616
110MP0000026_abnormal_inner_ear0.51495444
111MP0002234_abnormal_pharynx_morphology0.50909168
112MP0003183_abnormal_peptide_metabolism0.50099346
113MP0004484_altered_response_of0.49887604
114MP0005623_abnormal_meninges_morphology0.48431668

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.41212276
2Myokymia (HP:0002411)6.74695347
3Focal seizures (HP:0007359)5.73232556
4Visual hallucinations (HP:0002367)5.33217744
5Epileptic encephalopathy (HP:0200134)4.74477043
6Atonic seizures (HP:0010819)4.50197192
7Progressive cerebellar ataxia (HP:0002073)4.39148940
8Febrile seizures (HP:0002373)4.36615173
9Absence seizures (HP:0002121)4.13981080
10Limb dystonia (HP:0002451)3.91313215
11Dialeptic seizures (HP:0011146)3.76346625
12Generalized tonic-clonic seizures (HP:0002069)3.73938931
13Supranuclear gaze palsy (HP:0000605)3.63281606
14Action tremor (HP:0002345)3.51520090
15Broad-based gait (HP:0002136)3.48604209
16Ankle clonus (HP:0011448)3.37250000
17Hyperventilation (HP:0002883)3.36782140
18Mutism (HP:0002300)3.35745381
19Poor eye contact (HP:0000817)3.23688650
20Abnormal eating behavior (HP:0100738)3.14197505
21Amblyopia (HP:0000646)3.12784799
22Polyphagia (HP:0002591)3.12027831
23Depression (HP:0000716)3.11656689
24Impaired vibration sensation in the lower limbs (HP:0002166)3.04663742
25Drooling (HP:0002307)2.93404999
26Excessive salivation (HP:0003781)2.93404999
27Anxiety (HP:0000739)2.91747784
28Abnormal social behavior (HP:0012433)2.91375574
29Impaired social interactions (HP:0000735)2.91375574
30Gaze-evoked nystagmus (HP:0000640)2.88587439
31Truncal ataxia (HP:0002078)2.86189800
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.85758618
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.85758618
34Progressive inability to walk (HP:0002505)2.82859958
35Urinary bladder sphincter dysfunction (HP:0002839)2.81880786
36Pheochromocytoma (HP:0002666)2.77568534
37Papilledema (HP:0001085)2.77513610
38Failure to thrive in infancy (HP:0001531)2.75035116
39Dysdiadochokinesis (HP:0002075)2.74829485
40Dysmetria (HP:0001310)2.72750180
41Abnormality of the lower motor neuron (HP:0002366)2.71184243
42Torticollis (HP:0000473)2.63801964
43Genetic anticipation (HP:0003743)2.63368464
44Spastic tetraplegia (HP:0002510)2.62297167
45Peripheral hypomyelination (HP:0007182)2.62138560
46Cerebral hypomyelination (HP:0006808)2.61394006
47Cerebral inclusion bodies (HP:0100314)2.60677711
48Urinary urgency (HP:0000012)2.59931165
49Postural instability (HP:0002172)2.56593062
50Epileptiform EEG discharges (HP:0011182)2.55514798
51Cortical dysplasia (HP:0002539)2.53540149
52Spastic gait (HP:0002064)2.50631120
53Abnormality of the corticospinal tract (HP:0002492)2.50331643
54Amyotrophic lateral sclerosis (HP:0007354)2.48626254
55Agitation (HP:0000713)2.47997439
56Focal dystonia (HP:0004373)2.47991699
57EEG with generalized epileptiform discharges (HP:0011198)2.45011587
58Neuroendocrine neoplasm (HP:0100634)2.43859307
59Fetal akinesia sequence (HP:0001989)2.42231288
60Neurofibrillary tangles (HP:0002185)2.41684199
61Hemiparesis (HP:0001269)2.41417610
62Inability to walk (HP:0002540)2.36484421
63Bradykinesia (HP:0002067)2.36337165
64Split foot (HP:0001839)2.36177643
65Insidious onset (HP:0003587)2.35705965
66Termporal pattern (HP:0011008)2.35705965
67Hypsarrhythmia (HP:0002521)2.32691857
68Abnormality of binocular vision (HP:0011514)2.31101913
69Diplopia (HP:0000651)2.31101913
70Stereotypic behavior (HP:0000733)2.30910706
71Absent speech (HP:0001344)2.27765126
72Impaired smooth pursuit (HP:0007772)2.26377676
73Clonus (HP:0002169)2.24468852
74Craniofacial dystonia (HP:0012179)2.22293704
75Scanning speech (HP:0002168)2.20405746
76Hypoventilation (HP:0002791)2.20170600
77Sleep apnea (HP:0010535)2.17299202
78Akinesia (HP:0002304)2.14811498
79Pachygyria (HP:0001302)2.14421061
80Neuronal loss in central nervous system (HP:0002529)2.14020929
81Lower limb muscle weakness (HP:0007340)2.13704621
82Hypoplasia of the corpus callosum (HP:0002079)2.13161229
83Aplasia/Hypoplasia of the brainstem (HP:0007362)2.10355105
84Hypoplasia of the brainstem (HP:0002365)2.10355105
85Gait imbalance (HP:0002141)2.10055538
86Specific learning disability (HP:0001328)2.07192253
87Abnormal hair whorl (HP:0010721)2.05058153
88Status epilepticus (HP:0002133)2.04913034
89Congenital primary aphakia (HP:0007707)2.04294075
90Muscular hypotonia of the trunk (HP:0008936)2.03872778
91Abnormality of ocular smooth pursuit (HP:0000617)2.03719830
92Abnormality of the labia minora (HP:0012880)2.02221677
93Poor suck (HP:0002033)1.98690888
94Nephrogenic diabetes insipidus (HP:0009806)1.98621123
95Ulnar claw (HP:0001178)1.98610955
96Apathy (HP:0000741)1.98509120
97Medial flaring of the eyebrow (HP:0010747)1.97834736
98Hemiplegia (HP:0002301)1.96192106
99Psychosis (HP:0000709)1.94913422
100Generalized myoclonic seizures (HP:0002123)1.94693075
101Intention tremor (HP:0002080)1.94139002
102CNS hypomyelination (HP:0003429)1.93662209
103Megalencephaly (HP:0001355)1.93042843
104Abnormality of salivation (HP:0100755)1.92763817
105Incomplete penetrance (HP:0003829)1.92223592
106Delusions (HP:0000746)1.91736470
107Impaired vibratory sensation (HP:0002495)1.90926559
108Protruding tongue (HP:0010808)1.90259447
109Diminished motivation (HP:0000745)1.89932664
110Paraplegia (HP:0010550)1.89807988
111Esotropia (HP:0000565)1.89215713
112Intellectual disability, severe (HP:0010864)1.89080222
113Lissencephaly (HP:0001339)1.89073827
114Ventricular fibrillation (HP:0001663)1.86624483
115Obstructive sleep apnea (HP:0002870)1.85482185
116Blue irides (HP:0000635)1.82400356
117Gait ataxia (HP:0002066)1.82309743
118Inappropriate behavior (HP:0000719)1.81002636
119Morphological abnormality of the pyramidal tract (HP:0002062)1.78750685
120Hyperthyroidism (HP:0000836)1.77767984
121Retinal dysplasia (HP:0007973)1.75826726
122Neoplasm of the peripheral nervous system (HP:0100007)1.75466414

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.28116101
2MARK14.10825686
3MAP3K93.75339512
4EPHA43.66639175
5MAP3K42.99902829
6MINK12.90614009
7MAP3K122.68307973
8MAP2K72.64231174
9CASK2.43443553
10DAPK22.34991128
11NTRK22.29746589
12PAK62.01371116
13MAP2K41.98749788
14KSR11.89478890
15KSR21.86763401
16MAPK131.76553548
17PNCK1.66185676
18PLK21.66171858
19NTRK11.62419041
20DAPK11.59702815
21ARAF1.55968663
22GRK51.52810226
23CDK51.52162725
24SIK21.48734729
25CAMKK11.46687480
26MAP4K21.45409325
27TRIM281.44052160
28RIPK41.42213464
29TNIK1.42065794
30CDK191.40373767
31UHMK11.28301501
32PRKCG1.27108321
33PHKG11.26340427
34PHKG21.26340427
35PRPF4B1.23205865
36SIK31.21013842
37CSNK1A1L1.13685153
38LATS21.12799629
39PRKD31.10872424
40CAMKK21.07556356
41CSNK1G21.06438412
42CDK181.05945879
43TYRO31.04672779
44CAMK2A1.04221316
45CDK141.00163168
46CDK150.99384285
47FES0.95052873
48CSNK1G10.90812012
49MAP3K20.90520337
50SGK4940.89869925
51SGK2230.89869925
52CDK11A0.87022442
53STK380.86601396
54PAK30.86077260
55TESK10.85203649
56CAMK2B0.85156591
57MAP3K130.81118983
58RET0.80702487
59PKN10.80630502
60EPHA30.80541636
61DYRK1A0.79407251
62BCR0.75573436
63CAMK10.74593719
64SGK20.74126541
65STK110.70616503
66RAF10.70225277
67PTK2B0.70109992
68OXSR10.68456997
69TAOK10.67864436
70MARK20.67718658
71ERBB30.64210358
72CSNK1G30.62450262
73DYRK20.61766716
74PRKCH0.60594392
75LMTK20.60291521
76BMPR20.60137650
77PRKCZ0.57458801
78SGK10.57378575
79CCNB10.56692519
80NME10.55224543
81DYRK1B0.51140584
82PRKCE0.51132211
83WNK30.51128582
84CAMK1G0.50798099
85SGK30.50657151
86RPS6KA20.50653746
87CAMK2G0.48039729
88BRAF0.46852843
89LIMK10.46639684
90CAMK2D0.46577433
91MAP3K10.45068545
92MAP3K110.43610982
93MAP3K60.43163383
94ALK0.42976114
95PRKACA0.42343998
96FER0.42002407
97PDK10.41462000
98FGR0.41278173
99GRK70.41069809
100AKT30.40352486
101CSNK1D0.40170953
102MAP2K10.39781439
103FYN0.39094663
104RPS6KA30.39039455
105PINK10.38905794
106PDPK10.38081141
107PRKG10.36845472
108CAMK40.36221086
109CSNK1A10.35452110
110ADRBK10.35269354
111DYRK30.34061436
112DAPK30.33794771
113MAPK100.33574480
114MAPK120.32029390
115CSNK1E0.31357737
116PRKAA10.30525817
117PRKCA0.30280549
118MAP3K50.29437829
119PRKACB0.27711411
120ADRBK20.27209522
121PRKCB0.26714827
122MAPK90.26413411
123MAPK80.25432960
124MAPK40.24145003

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.89271075
2Synaptic vesicle cycle_Homo sapiens_hsa047213.65768420
3Olfactory transduction_Homo sapiens_hsa047402.81015308
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70016786
5GABAergic synapse_Homo sapiens_hsa047272.69372412
6Circadian entrainment_Homo sapiens_hsa047132.66307107
7Long-term potentiation_Homo sapiens_hsa047202.60484773
8Amphetamine addiction_Homo sapiens_hsa050312.54712472
9Glutamatergic synapse_Homo sapiens_hsa047242.50870746
10Morphine addiction_Homo sapiens_hsa050322.46915666
11Dopaminergic synapse_Homo sapiens_hsa047282.36005924
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28708393
13Salivary secretion_Homo sapiens_hsa049702.00176300
14Cholinergic synapse_Homo sapiens_hsa047251.99545284
15Insulin secretion_Homo sapiens_hsa049111.93014589
16Cocaine addiction_Homo sapiens_hsa050301.91688341
17Serotonergic synapse_Homo sapiens_hsa047261.87513623
18Collecting duct acid secretion_Homo sapiens_hsa049661.86854829
19Taste transduction_Homo sapiens_hsa047421.86801230
20Gastric acid secretion_Homo sapiens_hsa049711.75141590
21Long-term depression_Homo sapiens_hsa047301.74288042
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73800593
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70847161
24Renin secretion_Homo sapiens_hsa049241.62558090
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57371564
26Oxytocin signaling pathway_Homo sapiens_hsa049211.55449607
27Calcium signaling pathway_Homo sapiens_hsa040201.48801025
28Gap junction_Homo sapiens_hsa045401.44694498
29GnRH signaling pathway_Homo sapiens_hsa049121.40775486
30Axon guidance_Homo sapiens_hsa043601.34593210
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30889313
32Vibrio cholerae infection_Homo sapiens_hsa051101.24465223
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19536877
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19205588
35cAMP signaling pathway_Homo sapiens_hsa040241.17883957
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15234937
37Estrogen signaling pathway_Homo sapiens_hsa049151.13323510
38Cardiac muscle contraction_Homo sapiens_hsa042601.07732561
39Glioma_Homo sapiens_hsa052141.06282063
40ErbB signaling pathway_Homo sapiens_hsa040121.04500837
41Melanogenesis_Homo sapiens_hsa049161.03087480
42Type II diabetes mellitus_Homo sapiens_hsa049301.02309872
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95021992
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93196331
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92860940
46Oocyte meiosis_Homo sapiens_hsa041140.91875084
47Phototransduction_Homo sapiens_hsa047440.89623759
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89149779
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86643229
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79671428
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.78312260
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77635940
53Butanoate metabolism_Homo sapiens_hsa006500.75262072
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.70702961
55Dorso-ventral axis formation_Homo sapiens_hsa043200.70229823
56Pancreatic secretion_Homo sapiens_hsa049720.69523165
57Alzheimers disease_Homo sapiens_hsa050100.69070452
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.68921436
59Thyroid hormone synthesis_Homo sapiens_hsa049180.67824151
60Choline metabolism in cancer_Homo sapiens_hsa052310.66865497
61MAPK signaling pathway_Homo sapiens_hsa040100.66607024
62Alcoholism_Homo sapiens_hsa050340.66486019
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66006871
64Regulation of autophagy_Homo sapiens_hsa041400.65992014
65Oxidative phosphorylation_Homo sapiens_hsa001900.64178405
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60704920
67Dilated cardiomyopathy_Homo sapiens_hsa054140.59922489
68VEGF signaling pathway_Homo sapiens_hsa043700.59358472
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59297845
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57765986
71Parkinsons disease_Homo sapiens_hsa050120.57699158
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55951243
73Ras signaling pathway_Homo sapiens_hsa040140.55904321
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55834070
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53566515
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53545165
77Glucagon signaling pathway_Homo sapiens_hsa049220.52545325
78Endometrial cancer_Homo sapiens_hsa052130.52536077
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.51693341
80Prion diseases_Homo sapiens_hsa050200.51223735
81Vitamin B6 metabolism_Homo sapiens_hsa007500.51176847
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50633339
83Type I diabetes mellitus_Homo sapiens_hsa049400.47374296
84Rap1 signaling pathway_Homo sapiens_hsa040150.46990651
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46643601
86Ether lipid metabolism_Homo sapiens_hsa005650.44343154
87Wnt signaling pathway_Homo sapiens_hsa043100.43791018
88Insulin signaling pathway_Homo sapiens_hsa049100.42164004
89Endocytosis_Homo sapiens_hsa041440.41986020
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41632155
91Renal cell carcinoma_Homo sapiens_hsa052110.41428728
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40618356
93Colorectal cancer_Homo sapiens_hsa052100.40055793
94mTOR signaling pathway_Homo sapiens_hsa041500.38019651
95Phagosome_Homo sapiens_hsa041450.36891073
96Non-small cell lung cancer_Homo sapiens_hsa052230.35766043
97Bile secretion_Homo sapiens_hsa049760.34679822
98AMPK signaling pathway_Homo sapiens_hsa041520.34158866
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33807121
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33667424
101Inositol phosphate metabolism_Homo sapiens_hsa005620.33352335
102Huntingtons disease_Homo sapiens_hsa050160.33277250
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32613860
104Circadian rhythm_Homo sapiens_hsa047100.32453185
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32009299
106African trypanosomiasis_Homo sapiens_hsa051430.31476294
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30500491
108Ovarian steroidogenesis_Homo sapiens_hsa049130.28625391
109Rheumatoid arthritis_Homo sapiens_hsa053230.28139638
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27972680
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26801644
112beta-Alanine metabolism_Homo sapiens_hsa004100.25993504
113Fatty acid biosynthesis_Homo sapiens_hsa000610.25553173
114Steroid biosynthesis_Homo sapiens_hsa001000.24997202
115Salmonella infection_Homo sapiens_hsa051320.24395313
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23981049
117Hippo signaling pathway_Homo sapiens_hsa043900.23751670
118Arginine and proline metabolism_Homo sapiens_hsa003300.23231721
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22193623
120Tight junction_Homo sapiens_hsa045300.18630606

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