RTN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.95659570
2muscle filament sliding (GO:0030049)6.95659570
3sarcoplasmic reticulum calcium ion transport (GO:0070296)6.68117827
4regulation of skeletal muscle contraction (GO:0014819)6.54782670
5skeletal muscle contraction (GO:0003009)6.39779414
6actin-mediated cell contraction (GO:0070252)5.88140280
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.17598569
8skeletal muscle adaptation (GO:0043501)5.00397375
9response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.91591447
10regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.85293832
11regulation of cell communication by electrical coupling (GO:0010649)4.81174399
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.72793341
13neuronal action potential propagation (GO:0019227)4.71649514
14plasma membrane repair (GO:0001778)4.61240410
15striated muscle contraction (GO:0006941)4.42443396
16actin filament-based movement (GO:0030048)4.41000786
17skeletal muscle fiber development (GO:0048741)4.31857244
18sarcomere organization (GO:0045214)4.28517280
19myofibril assembly (GO:0030239)4.20022633
20response to inactivity (GO:0014854)4.05190155
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.01310356
22neuromuscular synaptic transmission (GO:0007274)3.95124391
23myotube cell development (GO:0014904)3.91062815
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.83781919
25positive regulation of myotube differentiation (GO:0010831)3.82980655
26skeletal muscle tissue development (GO:0007519)3.70941236
27regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.68024350
28regulation of short-term neuronal synaptic plasticity (GO:0048172)3.67478235
29negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.66140469
30negative regulation of calcium ion transmembrane transport (GO:1903170)3.66140469
31vocalization behavior (GO:0071625)3.61617860
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.52929788
33regulation of membrane repolarization (GO:0060306)3.50999922
34positive regulation of synapse maturation (GO:0090129)3.45125347
35regulation of calcium ion transmembrane transport (GO:1903169)3.44095966
36regulation of calcium ion transmembrane transporter activity (GO:1901019)3.44095966
37muscle contraction (GO:0006936)3.41594233
38membrane depolarization during action potential (GO:0086010)3.40393427
39regulation of relaxation of muscle (GO:1901077)3.40133441
40negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.39590852
41neuron cell-cell adhesion (GO:0007158)3.39410410
42negative regulation of muscle hypertrophy (GO:0014741)3.35320132
43muscle cell fate commitment (GO:0042693)3.29552278
44regulation of glutamate receptor signaling pathway (GO:1900449)3.28552810
45muscle cell cellular homeostasis (GO:0046716)3.25956594
46regulation of synapse structural plasticity (GO:0051823)3.24699962
47cardiac muscle contraction (GO:0060048)3.20555744
48striated muscle atrophy (GO:0014891)3.20293698
49polysaccharide catabolic process (GO:0000272)3.18463826
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.18323912
51glycogen biosynthetic process (GO:0005978)3.18063731
52glucan biosynthetic process (GO:0009250)3.18063731
53actomyosin structure organization (GO:0031032)3.17697923
54striated muscle adaptation (GO:0014888)3.15431909
55positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.14173656
56muscle atrophy (GO:0014889)3.13362717
57muscle fiber development (GO:0048747)3.13344052
58protein localization to synapse (GO:0035418)3.12867390
59glycogen catabolic process (GO:0005980)3.12658167
60negative regulation of protein localization to cell surface (GO:2000009)3.12101014
61ionotropic glutamate receptor signaling pathway (GO:0035235)3.11327458
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.11101378
63muscle system process (GO:0003012)3.10876095
64detection of calcium ion (GO:0005513)3.08758919
65locomotory exploration behavior (GO:0035641)3.08480167
66response to activity (GO:0014823)3.07423836
67regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.07200292
68synaptic vesicle maturation (GO:0016188)3.04964275
69cardiac muscle hypertrophy (GO:0003300)3.04107515
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03253090
71positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.02826561
72negative regulation of potassium ion transmembrane transport (GO:1901380)3.01421446
73postsynaptic membrane organization (GO:0001941)2.99838155
74cardiac myofibril assembly (GO:0055003)2.99734974
75regulation of striated muscle contraction (GO:0006942)2.98779182
76regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.98250155
77pyrimidine ribonucleoside catabolic process (GO:0046133)2.96298271
78regulation of actin filament-based movement (GO:1903115)2.94698854
79NADH metabolic process (GO:0006734)2.93107189
80response to parathyroid hormone (GO:0071107)2.90434825
81presynaptic membrane organization (GO:0097090)2.90235533
82synaptic transmission, glutamatergic (GO:0035249)2.90203542
83neuron recognition (GO:0008038)2.89571757
84fructose metabolic process (GO:0006000)2.89396606
85negative regulation of muscle contraction (GO:0045932)2.89261876
86regulation of synapse maturation (GO:0090128)2.89235243
87glucan catabolic process (GO:0009251)2.87394724
88gluconeogenesis (GO:0006094)2.87094497
89striated muscle hypertrophy (GO:0014897)2.86758062
90syncytium formation by plasma membrane fusion (GO:0000768)2.85361563
91glycogen metabolic process (GO:0005977)2.85136688
92calcium ion import (GO:0070509)2.84607176
93cerebellar granule cell differentiation (GO:0021707)2.84399049
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.83752438
95striated muscle cell development (GO:0055002)2.81890669
96presynaptic membrane assembly (GO:0097105)2.81393349
97regulation of cation channel activity (GO:2001257)2.80207206
98regulation of synaptic vesicle transport (GO:1902803)2.79513046
992-oxoglutarate metabolic process (GO:0006103)2.79159131
100glucan metabolic process (GO:0044042)2.78193800
101cellular glucan metabolic process (GO:0006073)2.78193800
102regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.77978772
103skeletal muscle tissue regeneration (GO:0043403)2.77796612
104positive regulation of cation channel activity (GO:2001259)2.76989119
105carnitine shuttle (GO:0006853)2.76833289
106dendritic spine morphogenesis (GO:0060997)2.76653785
107regulation of synaptic vesicle exocytosis (GO:2000300)2.76581703
108synaptic vesicle exocytosis (GO:0016079)2.74990415
109response to muscle activity (GO:0014850)2.73685302
110neuronal action potential (GO:0019228)2.73505982
111synaptic transmission, cholinergic (GO:0007271)2.72471647
112negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.71995608
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.71728721
114positive regulation of myoblast differentiation (GO:0045663)2.70215854
115axonal fasciculation (GO:0007413)2.69546209
116creatine metabolic process (GO:0006600)2.68344803
117respiratory system process (GO:0003016)2.68192818
118muscle organ development (GO:0007517)2.67943503
119heart process (GO:0003015)2.66973575
120neuron-neuron synaptic transmission (GO:0007270)2.66033116
121muscle structure development (GO:0061061)2.65282404
122positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64291112
123muscle adaptation (GO:0043500)2.61911972
124glutamate receptor signaling pathway (GO:0007215)2.60464204
125cellular polysaccharide catabolic process (GO:0044247)2.60400727
126glutamate secretion (GO:0014047)2.59139262
127myoblast fusion (GO:0007520)2.56563870
128negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.55069186
129myotube differentiation (GO:0014902)2.55062776
130membrane depolarization (GO:0051899)2.54416432
131regulation of long-term neuronal synaptic plasticity (GO:0048169)2.53144800
132regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.52401155
133cerebral cortex radially oriented cell migration (GO:0021799)2.52302633
134regulation of neuronal synaptic plasticity (GO:0048168)2.51960458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.01680037
2GBX2_23144817_ChIP-Seq_PC3_Human3.24720482
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.05840849
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83480170
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79208799
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.67498477
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61068218
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53521625
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53521625
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51389201
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45302913
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.41110763
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34816429
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25255790
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23540342
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.22293460
17LXR_22292898_ChIP-Seq_THP-1_Human2.21370013
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20364081
19DROSHA_22980978_ChIP-Seq_HELA_Human2.19672665
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18904561
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16611873
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13943094
23AR_21572438_ChIP-Seq_LNCaP_Human2.08392271
24* REST_21632747_ChIP-Seq_MESCs_Mouse2.02634906
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.00565363
26* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.90856838
27PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.89828260
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88703221
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.87546550
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.86828808
31SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.82841941
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.78983935
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78816750
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78031732
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76495617
36KDM2B_26808549_Chip-Seq_K562_Human1.76090840
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73067005
38* RARB_27405468_Chip-Seq_BRAIN_Mouse1.71002737
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.69619287
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.63339569
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63331432
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60724470
43* REST_18959480_ChIP-ChIP_MESCs_Mouse1.57902627
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57728280
45KDM2B_26808549_Chip-Seq_DND41_Human1.56484110
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54385192
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53485896
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53295097
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51540325
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.51435122
51SMAD4_21799915_ChIP-Seq_A2780_Human1.45935210
52SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43839599
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43553181
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43471485
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41847296
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41284873
57P68_20966046_ChIP-Seq_HELA_Human1.39351104
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38761896
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.37527500
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36685890
61ZNF274_21170338_ChIP-Seq_K562_Hela1.34827901
62SA1_27219007_Chip-Seq_Bcells_Human1.34418808
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33104074
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31966651
65VDR_22108803_ChIP-Seq_LS180_Human1.31100426
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29947979
67TAF15_26573619_Chip-Seq_HEK293_Human1.27055087
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.26958611
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25377453
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25166272
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.24715866
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.24715866
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24192865
74P300_19829295_ChIP-Seq_ESCs_Human1.23325842
75MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21758761
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.21720368
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.21593250
78RNF2_27304074_Chip-Seq_NSC_Mouse1.21189430
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20962255
80SMC4_20622854_ChIP-Seq_HELA_Human1.20411936
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20322886
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20273645
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19508797
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.19170559
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18379261
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17973498
87* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.17488397
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.17282443
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16615602
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.16424498
91TET1_21490601_ChIP-Seq_MESCs_Mouse1.16257575
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15935465
93TCF7_22412390_ChIP-Seq_EML_Mouse1.15597667
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14412002
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.14384429
96AR_25329375_ChIP-Seq_VCAP_Human1.14153482
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13616654
98* OCT4_19829295_ChIP-Seq_ESCs_Human1.13230568
99IGF1R_20145208_ChIP-Seq_DFB_Human1.12276628
100IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09972471
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.09893947
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09743236
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.09465410
104ER_23166858_ChIP-Seq_MCF-7_Human1.08747915
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07590658
106STAT3_23295773_ChIP-Seq_U87_Human1.07576260
107CREB1_26743006_Chip-Seq_LNCaP_Human1.07379541
108RACK7_27058665_Chip-Seq_MCF-7_Human1.06754441
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06728720
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06508027
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06165580
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05938946
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05266123
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04494863
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04163149
116ELK3_25401928_ChIP-Seq_HUVEC_Human1.03731071
117TCF4_23295773_ChIP-Seq_U87_Human1.02938300
118RING1B_27294783_Chip-Seq_NPCs_Mouse1.02922126
119* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01962896
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01693510
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01332990
122MYC_27129775_Chip-Seq_CORNEA_Mouse1.01010673
123* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00497153
124* AR_19668381_ChIP-Seq_PC3_Human1.00361249
125DPY_21335234_ChIP-Seq_ESCs_Mouse0.99898182
126TP53_20018659_ChIP-ChIP_R1E_Mouse0.99609888
127* CTCF_27219007_Chip-Seq_Bcells_Human0.98934168
128SPI1_20517297_ChIP-Seq_HL60_Human0.98904680
129E2F1_18555785_Chip-Seq_ESCs_Mouse0.98893468
130SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98785450
131KDM2B_26808549_Chip-Seq_JURKAT_Human0.98323708
132TP53_23651856_ChIP-Seq_MEFs_Mouse0.97927635
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97078934
134NANOG_18555785_Chip-Seq_ESCs_Mouse0.96995549
135FUS_26573619_Chip-Seq_HEK293_Human0.96875378
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96632561
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95054159
138GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94891752
139CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94827501
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.94656199
141AHR_22903824_ChIP-Seq_MCF-7_Human0.94559652
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.94506438
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94332833
144NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93994483
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93807748
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93495622
147SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93195463
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93021231
149TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93021231
150* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92934251
151PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92650613
152RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91993511
153ELF1_20517297_ChIP-Seq_JURKAT_Human0.91839469
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.91365200
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90469733
156P53_22387025_ChIP-Seq_ESCs_Mouse0.89942481
157CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89778280
158TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88660326
159PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88244963
160SMAD3_21741376_ChIP-Seq_HESCs_Human0.87913592
161WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87803685
162BCOR_27268052_Chip-Seq_Bcells_Human0.87360423
163TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86795372
164NFE2_27457419_Chip-Seq_LIVER_Mouse0.85143163
165SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84656841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio5.48692817
2MP0000751_myopathy4.64433754
3MP0003646_muscle_fatigue4.61388804
4MP0000749_muscle_degeneration4.33566898
5MP0004859_abnormal_synaptic_plasticity3.50962755
6MP0002837_dystrophic_cardiac_calcinosis3.20436928
7MP0004270_analgesia3.07820392
8MP0005451_abnormal_body_composition3.05809437
9MP0002106_abnormal_muscle_physiology2.90394193
10MP0000747_muscle_weakness2.81191570
11MP0004036_abnormal_muscle_relaxation2.63246239
12MP0000759_abnormal_skeletal_muscle2.61247295
13MP0005369_muscle_phenotype2.47516445
14MP0005620_abnormal_muscle_contractility2.36468358
15MP0003880_abnormal_central_pattern2.36105908
16MP0003635_abnormal_synaptic_transmissio2.29802733
17MP0004087_abnormal_muscle_fiber2.22818953
18MP0002269_muscular_atrophy2.08036083
19MP0000750_abnormal_muscle_regeneration1.96983127
20MP0002734_abnormal_mechanical_nocicepti1.95386690
21MP0004510_myositis1.93919981
22MP0005423_abnormal_somatic_nervous1.93724582
23MP0009745_abnormal_behavioral_response1.88913608
24MP0002063_abnormal_learning/memory/cond1.79562585
25MP0004215_abnormal_myocardial_fiber1.70567134
26MP0004233_abnormal_muscle_weight1.68184650
27MP0001486_abnormal_startle_reflex1.66289857
28MP0009046_muscle_twitch1.58796616
29MP0002735_abnormal_chemical_nociception1.57572264
30MP0002822_catalepsy1.57183704
31MP0002064_seizures1.55912975
32* MP0004130_abnormal_muscle_cell1.53922078
33MP0001968_abnormal_touch/_nociception1.51295935
34MP0002272_abnormal_nervous_system1.47013423
35MP0006276_abnormal_autonomic_nervous1.46930515
36MP0003137_abnormal_impulse_conducting1.46829176
37MP0002572_abnormal_emotion/affect_behav1.46155916
38MP0001440_abnormal_grooming_behavior1.45282770
39MP0002108_abnormal_muscle_morphology1.42085677
40MP0002184_abnormal_innervation1.40321410
41MP0004484_altered_response_of1.40262244
42MP0005330_cardiomyopathy1.38401830
43MP0002067_abnormal_sensory_capabilities1.38382225
44MP0006292_abnormal_olfactory_placode1.33124565
45MP0000778_abnormal_nervous_system1.31629790
46MP0008569_lethality_at_weaning1.30961620
47MP0002332_abnormal_exercise_endurance1.29273930
48MP0002972_abnormal_cardiac_muscle1.29075242
49MP0005645_abnormal_hypothalamus_physiol1.28499915
50MP0004084_abnormal_cardiac_muscle1.27048992
51MP0001188_hyperpigmentation1.25826900
52MP0005167_abnormal_blood-brain_barrier1.24255914
53MP0005646_abnormal_pituitary_gland1.21909108
54MP0001984_abnormal_olfaction1.15637224
55MP0002557_abnormal_social/conspecific_i1.14739088
56MP0002733_abnormal_thermal_nociception1.14100004
57MP0001970_abnormal_pain_threshold1.14032243
58MP0000733_abnormal_muscle_development1.13407322
59MP0002736_abnormal_nociception_after1.12151404
60MP0000955_abnormal_spinal_cord1.09150136
61MP0004142_abnormal_muscle_tone1.06515486
62MP0004858_abnormal_nervous_system1.04376607
63MP0002638_abnormal_pupillary_reflex1.03956093
64MP0006138_congestive_heart_failure1.01980700
65MP0002066_abnormal_motor_capabilities/c1.01331029
66MP0003123_paternal_imprinting1.01199202
67MP0004085_abnormal_heartbeat1.00899266
68MP0002234_abnormal_pharynx_morphology0.99263005
69MP0002882_abnormal_neuron_morphology0.98476986
70MP0003329_amyloid_beta_deposits0.98335746
71MP0004811_abnormal_neuron_physiology0.98255537
72MP0005386_behavior/neurological_phenoty0.95318195
73MP0004924_abnormal_behavior0.95318195
74MP0004185_abnormal_adipocyte_glucose0.92351728
75MP0001502_abnormal_circadian_rhythm0.91026800
76MP0001529_abnormal_vocalization0.90122615
77MP0005266_abnormal_metabolism0.88779707
78MP0002971_abnormal_brown_adipose0.88024258
79MP0001501_abnormal_sleep_pattern0.86149848
80MP0001299_abnormal_eye_distance/0.85899984
81MP0005464_abnormal_platelet_physiology0.81761880
82MP0009780_abnormal_chondrocyte_physiolo0.80853778
83MP0003879_abnormal_hair_cell0.80238169
84MP0004742_abnormal_vestibular_system0.79682032
85MP0005666_abnormal_adipose_tissue0.79545302
86MP0005375_adipose_tissue_phenotype0.79183546
87MP0002102_abnormal_ear_morphology0.75618872
88MP0002752_abnormal_somatic_nervous0.75358176
89MP0008874_decreased_physiological_sensi0.74473477
90MP0002909_abnormal_adrenal_gland0.74319493
91MP0006036_abnormal_mitochondrial_physio0.73891480
92MP0000631_abnormal_neuroendocrine_gland0.73632128
93MP0005171_absent_coat_pigmentation0.73552183
94MP0009250_abnormal_appendicular_skeleto0.73188642
95MP0005058_abnormal_lysosome_morphology0.72573469
96MP0005535_abnormal_body_temperature0.69921421
97MP0005409_darkened_coat_color0.68105839
98MP0002127_abnormal_cardiovascular_syste0.67480657
99MP0001905_abnormal_dopamine_level0.67165919
100MP0004043_abnormal_pH_regulation0.66862142
101MP0001544_abnormal_cardiovascular_syste0.64948479
102MP0005385_cardiovascular_system_phenoty0.64948479
103MP0008775_abnormal_heart_ventricle0.64304137
104MP0010630_abnormal_cardiac_muscle0.63579921
105MP0003045_fibrosis0.63108924
106MP0003075_altered_response_to0.62949855
107MP0002152_abnormal_brain_morphology0.62373713
108MP0000013_abnormal_adipose_tissue0.62047100
109MP0000003_abnormal_adipose_tissue0.61820513
110MP0004885_abnormal_endolymph0.61190698
111MP0006072_abnormal_retinal_apoptosis0.61181472
112MP0004134_abnormal_chest_morphology0.61101512
113MP0003828_pulmonary_edema0.60904154
114MP0003787_abnormal_imprinting0.60824952
115MP0001963_abnormal_hearing_physiology0.59512649
116MP0003705_abnormal_hypodermis_morpholog0.58203035
117MP0000372_irregular_coat_pigmentation0.57872277
118MP0003221_abnormal_cardiomyocyte_apopto0.57740228
119MP0009840_abnormal_foam_cell0.55549441
120MP0003633_abnormal_nervous_system0.55465825
121MP0000026_abnormal_inner_ear0.55323398
122MP0000343_altered_response_to0.55062808
123MP0002229_neurodegeneration0.54748327
124MP0005083_abnormal_biliary_tract0.53539939
125MP0000230_abnormal_systemic_arterial0.51945934
126MP0005166_decreased_susceptibility_to0.49617250
127MP0004147_increased_porphyrin_level0.47706742
128MP0000920_abnormal_myelination0.47706241

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.05333472
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.79258992
3Exercise-induced myalgia (HP:0003738)7.51475064
4Nemaline bodies (HP:0003798)7.37611683
5Muscle hypertrophy of the lower extremities (HP:0008968)6.55074279
6Exercise-induced muscle cramps (HP:0003710)6.23812131
7Calf muscle hypertrophy (HP:0008981)6.03598784
8Type 1 muscle fiber predominance (HP:0003803)5.77230153
9Distal arthrogryposis (HP:0005684)5.53629506
10Myopathic facies (HP:0002058)5.27748980
11Difficulty running (HP:0009046)4.53690928
12Muscle fiber splitting (HP:0003555)4.53372810
13Round ear (HP:0100830)4.50782503
14EMG: myopathic abnormalities (HP:0003458)4.28766259
15Abnormality of the calf musculature (HP:0001430)4.28437702
16Hyporeflexia of lower limbs (HP:0002600)4.05908873
17Myotonia (HP:0002486)4.04999093
18Ulnar deviation of the wrist (HP:0003049)4.01848250
19Calcaneovalgus deformity (HP:0001848)3.77581836
20Muscle stiffness (HP:0003552)3.70938837
21Myoglobinuria (HP:0002913)3.70886636
22Absent phalangeal crease (HP:0006109)3.62857617
23Focal motor seizures (HP:0011153)3.55095387
24Abnormality of the left ventricular outflow tract (HP:0011103)3.50269781
25Subaortic stenosis (HP:0001682)3.50269781
26Deformed tarsal bones (HP:0008119)3.47576296
27Sudden death (HP:0001699)3.41513581
28Fetal akinesia sequence (HP:0001989)3.30426378
29Abnormality of skeletal muscle fiber size (HP:0012084)3.23802630
30Abnormal finger flexion creases (HP:0006143)3.17330676
31Increased connective tissue (HP:0009025)3.13467366
32Neck muscle weakness (HP:0000467)3.03105938
33Rimmed vacuoles (HP:0003805)3.03044722
34Hyperkalemia (HP:0002153)3.01608577
35Increased variability in muscle fiber diameter (HP:0003557)2.99240996
36Shoulder girdle muscle weakness (HP:0003547)2.95907212
37Malignant hyperthermia (HP:0002047)2.91401825
38Difficulty climbing stairs (HP:0003551)2.85681709
39Rhabdomyolysis (HP:0003201)2.71710337
40Abnormality of the musculature of the pelvis (HP:0001469)2.62674989
41Abnormality of the hip-girdle musculature (HP:0001445)2.62674989
42Fatigable weakness (HP:0003473)2.61180504
43Abnormality of the neuromuscular junction (HP:0003398)2.61180504
44Pelvic girdle muscle weakness (HP:0003749)2.60942099
45Febrile seizures (HP:0002373)2.59797912
46Areflexia of lower limbs (HP:0002522)2.53263899
47Frequent falls (HP:0002359)2.50967167
48Distal lower limb muscle weakness (HP:0009053)2.45258594
49Broad-based gait (HP:0002136)2.38733159
50Lower limb amyotrophy (HP:0007210)2.33680599
51Bulbar palsy (HP:0001283)2.31830715
52Bundle branch block (HP:0011710)2.27416457
53Nonprogressive disorder (HP:0003680)2.26975922
54Distal lower limb amyotrophy (HP:0008944)2.26344613
55Myokymia (HP:0002411)2.24933140
56Abnormal atrioventricular conduction (HP:0005150)2.20685077
57Asymmetric septal hypertrophy (HP:0001670)2.19260841
58Prolonged QT interval (HP:0001657)2.18076873
59Focal seizures (HP:0007359)2.16419164
60Muscular dystrophy (HP:0003560)2.13945947
61EMG: neuropathic changes (HP:0003445)2.12632808
62Muscle fiber atrophy (HP:0100295)2.12584063
63Visual hallucinations (HP:0002367)2.11309667
64Gowers sign (HP:0003391)2.08767781
65Dilated cardiomyopathy (HP:0001644)2.05621076
66Mildly elevated creatine phosphokinase (HP:0008180)2.00296423
67Limb-girdle muscle weakness (HP:0003325)2.00142426
68Hip contracture (HP:0003273)1.99653482
69Ventricular tachycardia (HP:0004756)1.99530730
70Atrial fibrillation (HP:0005110)1.99303498
71Generalized tonic-clonic seizures (HP:0002069)1.98687487
72Proximal amyotrophy (HP:0007126)1.97548204
73Atonic seizures (HP:0010819)1.92270020
74Generalized muscle weakness (HP:0003324)1.91772206
75Primary atrial arrhythmia (HP:0001692)1.91126906
76Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90897417
77Abnormal EKG (HP:0003115)1.90366302
78Weak cry (HP:0001612)1.89983322
79Abnormality of the shoulder girdle musculature (HP:0001435)1.87729308
80Slender build (HP:0001533)1.87367298
81Popliteal pterygium (HP:0009756)1.86229671
82Respiratory insufficiency due to muscle weakness (HP:0002747)1.83644650
83Centrally nucleated skeletal muscle fibers (HP:0003687)1.81894996
84Lipoatrophy (HP:0100578)1.80192578
85Progressive muscle weakness (HP:0003323)1.80136928
86Supraventricular tachycardia (HP:0004755)1.78576207
87Abnormality of the calcaneus (HP:0008364)1.75467048
88Metatarsus adductus (HP:0001840)1.74961966
89Easy fatigability (HP:0003388)1.74450991
90Achilles tendon contracture (HP:0001771)1.74116479
91Left ventricular hypertrophy (HP:0001712)1.72382564
92Supraventricular arrhythmia (HP:0005115)1.70774930
93Akinesia (HP:0002304)1.70318692
94Limb-girdle muscle atrophy (HP:0003797)1.69996325
95Absence seizures (HP:0002121)1.68763594
96Ventricular arrhythmia (HP:0004308)1.67705469
97Epileptic encephalopathy (HP:0200134)1.66600495
98Heart block (HP:0012722)1.66478701
99Foot dorsiflexor weakness (HP:0009027)1.65809120
100Spinal rigidity (HP:0003306)1.65428260
101Scapular winging (HP:0003691)1.64994040
102Abnormality of the Achilles tendon (HP:0005109)1.63315037
103Type 2 muscle fiber atrophy (HP:0003554)1.62802250
104Ventricular fibrillation (HP:0001663)1.62634452
105Abnormality of potassium homeostasis (HP:0011042)1.62093316
106Hypoplastic ischia (HP:0003175)1.62091804
107Waddling gait (HP:0002515)1.61862567
108Ulnar deviation of finger (HP:0009465)1.61379819
109Abnormality of the foot musculature (HP:0001436)1.59041160
110Paralysis (HP:0003470)1.57675034
111Syncope (HP:0001279)1.56437568
112Adducted thumb (HP:0001181)1.55408097
113Ragged-red muscle fibers (HP:0003200)1.55243839
114Poor eye contact (HP:0000817)1.54328129
115Dialeptic seizures (HP:0011146)1.53726978
116Atrioventricular block (HP:0001678)1.41291033
117Rapidly progressive (HP:0003678)1.40459478
118Congenital hip dislocation (HP:0001374)1.37972654
119Stridor (HP:0010307)1.37785739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.58589437
2PHKG24.92365541
3PHKG14.92365541
4MARK13.43560406
5TTN3.38401204
6NME12.64184322
7NTRK32.60144256
8INSRR2.54663022
9PINK12.43794559
10MUSK1.95864227
11EPHA41.89736857
12TNIK1.81960881
13PIK3CG1.77643056
14CASK1.71383756
15MAPK131.70580715
16MAP2K41.68179796
17MAP2K71.64814842
18MAP3K91.64658610
19MAP3K41.53421344
20MAP3K71.49526590
21PIK3CA1.40366298
22DMPK1.37300774
23MAP3K111.36802769
24PKN11.32452736
25MINK11.31678257
26MAPKAPK31.30068402
27PAK61.29555437
28ZAK1.29041428
29ARAF1.26886892
30NTRK21.25893607
31MAPK121.18406282
32MOS1.15918020
33ERBB31.14750245
34DYRK1B1.14536346
35RIPK11.08060634
36PRPF4B1.05765723
37NEK11.04829305
38DAPK21.02944474
39MAP2K61.01820633
40EEF2K1.01600830
41TRIB31.00188708
42LIMK10.97316191
43ICK0.89748597
44MAP3K120.84250063
45KSR10.81366921
46PRKD30.80208585
47STK240.78219848
48PDK30.78019136
49PDK40.78019136
50SIK10.77370831
51BCKDK0.76386944
52CDK50.75908836
53PRKAA10.75112083
54PNCK0.74418251
55UHMK10.74359182
56TAOK20.72877301
57IRAK20.72863578
58RIPK40.70837645
59SGK10.70321116
60SGK20.70197566
61DAPK30.69402190
62CAMK2A0.68383696
63PDPK10.67572195
64CCNB10.67256361
65CAMK2G0.66283259
66MARK20.66202121
67MAP2K30.66034723
68PRKCG0.64576806
69CDK190.63875857
70GRK50.63815705
71SIK20.63074009
72NEK60.62852139
73CAMK10.62719645
74TYRO30.62174570
75SGK4940.62122904
76SGK2230.62122904
77PLK20.61263493
78DYRK20.58732364
79STK110.58070628
80LMTK20.57551466
81PRKAA20.55768422
82GRK70.55412133
83BMX0.54612825
84STK380.53357153
85BRAF0.52831786
86RPS6KA20.52789979
87MAP2K10.52487242
88CAMK2D0.52085286
89CDC42BPA0.51569195
90MAPK40.51531163
91IRAK30.51179808
92SGK30.50915348
93SIK30.50730999
94PDK20.50536617
95PAK30.49883567
96LATS20.49489435
97PDK10.49064689
98PRKCE0.48182173
99ROCK10.47622154
100BMPR20.46357169
101PRKD20.46281577
102KSR20.46105892
103TNK20.45488455
104PRKG10.44358859
105TESK10.43975707
106MAPK70.43836070
107PRKACA0.40964026
108TAOK10.40449861
109MAP3K60.39592427
110RPS6KA30.39496402
111CDK150.39446219
112TRPM70.39221556
113PRKG20.39075206
114GRK10.38786107
115TBK10.38308336
116CAMKK10.38120607
117CDK11A0.37834227
118DDR20.37605156
119CAMK40.37414435
120MAP3K130.37024959
121DAPK10.36779903
122EPHB20.36630084
123DYRK1A0.35813558
124CAMK2B0.35221807
125CDK140.33908139
126PRKACB0.33681930
127MAPK100.33600000
128AKT20.32439797
129MAP3K10.32356523
130WNK10.32152176
131PRKCH0.31552240
132PRKD10.30006725
133IRAK10.29957683
134CDK30.28862450
135ROCK20.28777120
136CDK180.26699700
137NTRK10.26609392

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.12308380
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.80073995
3Dilated cardiomyopathy_Homo sapiens_hsa054142.69253187
4Nicotine addiction_Homo sapiens_hsa050332.67220214
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.56556151
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.52156654
7Olfactory transduction_Homo sapiens_hsa047402.38035094
8Oxytocin signaling pathway_Homo sapiens_hsa049212.26532307
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.20319254
10Circadian entrainment_Homo sapiens_hsa047132.16357347
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10939551
12Calcium signaling pathway_Homo sapiens_hsa040202.10023882
13GABAergic synapse_Homo sapiens_hsa047271.95851025
14Morphine addiction_Homo sapiens_hsa050321.95379514
15Synaptic vesicle cycle_Homo sapiens_hsa047211.94515999
16Glutamatergic synapse_Homo sapiens_hsa047241.89343211
17Insulin secretion_Homo sapiens_hsa049111.86058843
18Gastric acid secretion_Homo sapiens_hsa049711.72063591
19Cholinergic synapse_Homo sapiens_hsa047251.69356855
20Long-term potentiation_Homo sapiens_hsa047201.62568001
21Amphetamine addiction_Homo sapiens_hsa050311.59929315
22Taste transduction_Homo sapiens_hsa047421.57915427
23Circadian rhythm_Homo sapiens_hsa047101.56722740
24Dopaminergic synapse_Homo sapiens_hsa047281.52342252
25Arginine and proline metabolism_Homo sapiens_hsa003301.52255933
26Serotonergic synapse_Homo sapiens_hsa047261.51793865
27Parkinsons disease_Homo sapiens_hsa050121.46593807
28Renin secretion_Homo sapiens_hsa049241.46469900
29Oxidative phosphorylation_Homo sapiens_hsa001901.43654864
30Salivary secretion_Homo sapiens_hsa049701.43535606
31Alzheimers disease_Homo sapiens_hsa050101.42521896
32GnRH signaling pathway_Homo sapiens_hsa049121.40996272
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.39906272
34Long-term depression_Homo sapiens_hsa047301.37193324
35Phototransduction_Homo sapiens_hsa047441.32930948
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31050285
37Insulin signaling pathway_Homo sapiens_hsa049101.28621404
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.26957087
39Type II diabetes mellitus_Homo sapiens_hsa049301.26013318
40Axon guidance_Homo sapiens_hsa043601.22240296
41Pentose phosphate pathway_Homo sapiens_hsa000301.19487873
42Glucagon signaling pathway_Homo sapiens_hsa049221.18491529
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16683613
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11919710
45cAMP signaling pathway_Homo sapiens_hsa040241.08738354
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05107553
47Cocaine addiction_Homo sapiens_hsa050301.04090189
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02732563
49Gap junction_Homo sapiens_hsa045401.02724184
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02681235
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01502481
52MAPK signaling pathway_Homo sapiens_hsa040101.01061582
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00557185
54Platelet activation_Homo sapiens_hsa046110.96580819
55Carbon metabolism_Homo sapiens_hsa012000.95675992
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95356306
57Fructose and mannose metabolism_Homo sapiens_hsa000510.94363207
58Arginine biosynthesis_Homo sapiens_hsa002200.91093975
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89717081
60Melanogenesis_Homo sapiens_hsa049160.88267343
61Huntingtons disease_Homo sapiens_hsa050160.85603939
62Tight junction_Homo sapiens_hsa045300.82999783
63ErbB signaling pathway_Homo sapiens_hsa040120.81143812
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73821972
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73197477
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72986413
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72088936
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70754667
69Collecting duct acid secretion_Homo sapiens_hsa049660.70494634
70AMPK signaling pathway_Homo sapiens_hsa041520.69363106
71Glioma_Homo sapiens_hsa052140.66599908
72Starch and sucrose metabolism_Homo sapiens_hsa005000.66483070
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65333635
74Viral myocarditis_Homo sapiens_hsa054160.65224219
75Dorso-ventral axis formation_Homo sapiens_hsa043200.64391240
76Insulin resistance_Homo sapiens_hsa049310.63974645
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61850635
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61085275
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58330178
80FoxO signaling pathway_Homo sapiens_hsa040680.57511433
81Wnt signaling pathway_Homo sapiens_hsa043100.56856397
82Estrogen signaling pathway_Homo sapiens_hsa049150.55455141
83Pancreatic secretion_Homo sapiens_hsa049720.54955727
84Galactose metabolism_Homo sapiens_hsa000520.54780013
85Ras signaling pathway_Homo sapiens_hsa040140.54329273
86Endocytosis_Homo sapiens_hsa041440.53860862
87Amoebiasis_Homo sapiens_hsa051460.52136079
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51953149
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.51519380
90Biosynthesis of amino acids_Homo sapiens_hsa012300.51384901
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.51084785
92Choline metabolism in cancer_Homo sapiens_hsa052310.51036866
93Regulation of autophagy_Homo sapiens_hsa041400.49794950
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49480958
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.48427182
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46376187
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45817770
98mTOR signaling pathway_Homo sapiens_hsa041500.45633288
99VEGF signaling pathway_Homo sapiens_hsa043700.44923725
100Prion diseases_Homo sapiens_hsa050200.44803906
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44104424
102Oocyte meiosis_Homo sapiens_hsa041140.43673285
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43409403
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43047183
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42516970
106Melanoma_Homo sapiens_hsa052180.40811106
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40250437
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39926329
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39669115
110Focal adhesion_Homo sapiens_hsa045100.37769230
111Ovarian steroidogenesis_Homo sapiens_hsa049130.36937160
112Endometrial cancer_Homo sapiens_hsa052130.36576555
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35349722
114Renal cell carcinoma_Homo sapiens_hsa052110.35157465
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34980187
116Rap1 signaling pathway_Homo sapiens_hsa040150.34448745
117Prolactin signaling pathway_Homo sapiens_hsa049170.33831963
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.30730228
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.30136064
120HIF-1 signaling pathway_Homo sapiens_hsa040660.29451014
121Non-small cell lung cancer_Homo sapiens_hsa052230.28547216
122Hedgehog signaling pathway_Homo sapiens_hsa043400.27487973

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