RTN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.22042338
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.01296331
3locomotory exploration behavior (GO:0035641)5.58076467
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52330857
5synaptic vesicle exocytosis (GO:0016079)5.44963517
6glutamate secretion (GO:0014047)5.31582110
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11190621
8vocalization behavior (GO:0071625)5.00192262
9regulation of synaptic vesicle exocytosis (GO:2000300)4.99332624
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.81110080
11layer formation in cerebral cortex (GO:0021819)4.65083464
12regulation of glutamate receptor signaling pathway (GO:1900449)4.55552394
13protein localization to synapse (GO:0035418)4.55112261
14exploration behavior (GO:0035640)4.54081779
15neuron cell-cell adhesion (GO:0007158)4.48756529
16regulation of synaptic vesicle transport (GO:1902803)4.47704075
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.37305022
18cerebellar granule cell differentiation (GO:0021707)4.37182935
19neurotransmitter secretion (GO:0007269)4.35666693
20establishment of mitochondrion localization (GO:0051654)4.33838444
21amino acid import (GO:0043090)4.30238001
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.27965656
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.26225571
24regulation of neuronal synaptic plasticity (GO:0048168)4.24059183
25cellular potassium ion homeostasis (GO:0030007)4.21584021
26neuronal action potential propagation (GO:0019227)4.20079389
27proline transport (GO:0015824)4.16331307
28regulation of synapse structural plasticity (GO:0051823)4.13244744
29presynaptic membrane assembly (GO:0097105)4.09983888
30pyrimidine nucleobase catabolic process (GO:0006208)4.09065103
31sodium ion export (GO:0071436)4.08211192
32dendritic spine morphogenesis (GO:0060997)4.00317853
33presynaptic membrane organization (GO:0097090)3.93173957
34neuronal ion channel clustering (GO:0045161)3.90102908
35gamma-aminobutyric acid transport (GO:0015812)3.86033952
36glutamate receptor signaling pathway (GO:0007215)3.80852718
37synaptic transmission, glutamatergic (GO:0035249)3.77244625
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.75509741
39neuron recognition (GO:0008038)3.65047334
40activation of protein kinase A activity (GO:0034199)3.63589291
41neurotransmitter transport (GO:0006836)3.59554230
42neuron-neuron synaptic transmission (GO:0007270)3.57626511
43long-term memory (GO:0007616)3.54210650
44dendrite morphogenesis (GO:0048813)3.49529400
45neurotransmitter-gated ion channel clustering (GO:0072578)3.49250026
46establishment of synaptic vesicle localization (GO:0097480)3.47992068
47synaptic vesicle transport (GO:0048489)3.47992068
48positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.47426411
49nucleobase catabolic process (GO:0046113)3.46945859
50regulation of voltage-gated calcium channel activity (GO:1901385)3.44823034
51positive regulation of membrane potential (GO:0045838)3.44415697
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.44414658
53axonal fasciculation (GO:0007413)3.42134332
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.40950246
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.38305908
56regulation of synaptic plasticity (GO:0048167)3.38264229
57regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.36706483
58acidic amino acid transport (GO:0015800)3.36394073
59neuromuscular process controlling balance (GO:0050885)3.36373304
60potassium ion homeostasis (GO:0055075)3.35708012
61cell communication by electrical coupling (GO:0010644)3.35426014
62synaptic vesicle endocytosis (GO:0048488)3.31866210
63negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30999228
64potassium ion import (GO:0010107)3.30437132
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30196335
66positive regulation of synapse maturation (GO:0090129)3.30106452
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.29931638
68regulation of neurotransmitter levels (GO:0001505)3.29731218
69neuromuscular process controlling posture (GO:0050884)3.28623980
70regulation of postsynaptic membrane potential (GO:0060078)3.27579926
71regulation of vesicle fusion (GO:0031338)3.27159977
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24846047
73glycine transport (GO:0015816)3.24062152
74regulation of dendritic spine morphogenesis (GO:0061001)3.22370777
75regulation of neurotransmitter secretion (GO:0046928)3.21925218
76vesicle transport along microtubule (GO:0047496)3.21551630
77transmission of nerve impulse (GO:0019226)3.21176596
78neurotransmitter uptake (GO:0001504)3.20098914
79axon ensheathment in central nervous system (GO:0032291)3.17488317
80central nervous system myelination (GO:0022010)3.17488317
81gamma-aminobutyric acid signaling pathway (GO:0007214)3.17313502
82response to auditory stimulus (GO:0010996)3.17256500
83innervation (GO:0060384)3.14375338
84establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.14162467
85mitochondrion transport along microtubule (GO:0047497)3.14162467
86cerebellar Purkinje cell differentiation (GO:0021702)3.14045378
87long-term synaptic potentiation (GO:0060291)3.13281950
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11485588
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.09029325
90regulation of synapse maturation (GO:0090128)3.08711761
91organelle transport along microtubule (GO:0072384)3.07380849
92mating behavior (GO:0007617)3.05230352
93positive regulation of synapse assembly (GO:0051965)3.04399871
94establishment of vesicle localization (GO:0051650)3.03547057
95positive regulation of neurotransmitter secretion (GO:0001956)3.03136408
96regulation of dendritic spine development (GO:0060998)3.03033771
97neuromuscular synaptic transmission (GO:0007274)3.02023724
98negative regulation of synaptic transmission, GABAergic (GO:0032229)3.00771025
99positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00513235
100negative regulation of microtubule polymerization (GO:0031115)2.99955038
101auditory behavior (GO:0031223)2.99310236
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99152519
103cell migration in hindbrain (GO:0021535)2.98847515
104postsynaptic membrane organization (GO:0001941)2.98747143
105regulation of neurotransmitter transport (GO:0051588)2.97876195
106negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96908518
107synapse assembly (GO:0007416)2.96402780
108membrane depolarization during action potential (GO:0086010)2.95981984
109axon cargo transport (GO:0008088)2.91935243
110membrane hyperpolarization (GO:0060081)2.90969602
111G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.89601738
112membrane depolarization (GO:0051899)2.88765829
113cellular sodium ion homeostasis (GO:0006883)2.87310054
114L-amino acid import (GO:0043092)2.86839542
115positive regulation of potassium ion transmembrane transport (GO:1901381)2.86546292
116learning (GO:0007612)2.86372412
117neuromuscular process (GO:0050905)2.86229770
118social behavior (GO:0035176)2.86012408
119intraspecies interaction between organisms (GO:0051703)2.86012408
120prepulse inhibition (GO:0060134)2.85989601
121regulation of ARF protein signal transduction (GO:0032012)2.85349585
122response to histamine (GO:0034776)2.84764581
123behavioral defense response (GO:0002209)2.84482748
124behavioral fear response (GO:0001662)2.84482748
125positive regulation of dendritic spine development (GO:0060999)2.84298906
126regulation of synaptic transmission (GO:0050804)2.84213506
127cerebellar Purkinje cell layer development (GO:0021680)2.84019555
128dendritic spine organization (GO:0097061)2.83887709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.80897485
2GBX2_23144817_ChIP-Seq_PC3_Human3.20908435
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14613140
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04812488
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03741834
6REST_21632747_ChIP-Seq_MESCs_Mouse2.75501931
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74806585
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74806585
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63450053
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.60984644
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58762490
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57999487
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57331204
14DROSHA_22980978_ChIP-Seq_HELA_Human2.54192727
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54033163
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47003774
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.41313628
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.30469013
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28645906
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.25440254
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.18230392
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.17217568
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04275912
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01734848
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98060162
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97021201
27AR_21572438_ChIP-Seq_LNCaP_Human1.96717696
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95069287
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94005081
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93561890
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.81929817
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72992830
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71146370
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66987907
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54370155
36SMAD4_21799915_ChIP-Seq_A2780_Human1.52157576
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.51206858
38ZNF274_21170338_ChIP-Seq_K562_Hela1.50926539
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50234955
40TAF15_26573619_Chip-Seq_HEK293_Human1.48167185
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43797094
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.36922317
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35720140
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.34855320
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.31561004
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.31024775
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31008648
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30835052
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29469891
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26102071
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25444765
52FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25408741
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23598428
54KDM2B_26808549_Chip-Seq_K562_Human1.22474615
55AR_19668381_ChIP-Seq_PC3_Human1.22445273
56* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22008686
57P300_19829295_ChIP-Seq_ESCs_Human1.21928194
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21478649
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21140721
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20449205
61STAT3_23295773_ChIP-Seq_U87_Human1.18990339
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.18852781
63AR_25329375_ChIP-Seq_VCAP_Human1.16871608
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15855336
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15601525
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15478905
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14792974
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14530960
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.11670117
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10293445
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10053184
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08940278
73* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07466462
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07264930
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05614844
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05302810
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.04873969
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.04297785
79IGF1R_20145208_ChIP-Seq_DFB_Human1.04146439
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.02945098
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00879531
82AHR_22903824_ChIP-Seq_MCF-7_Human0.99996321
83TCF4_23295773_ChIP-Seq_U87_Human0.98300789
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96957906
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.96713395
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94927411
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94726758
88TET1_21490601_ChIP-Seq_MESCs_Mouse0.94481402
89* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94326439
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94059281
91RXR_22108803_ChIP-Seq_LS180_Human0.94004019
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.92538210
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92417011
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91634326
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90002671
96SOX9_26525672_Chip-Seq_HEART_Mouse0.89602756
97TP53_16413492_ChIP-PET_HCT116_Human0.88780741
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88693865
99EGR1_19032775_ChIP-ChIP_M12_Human0.88094223
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87636400
101RUNX2_22187159_ChIP-Seq_PCA_Human0.87631723
102RNF2_27304074_Chip-Seq_NSC_Mouse0.86803779
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85815109
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85467233
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84923272
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.84559652
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83009925
108* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82529536
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82295802
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81688279
111CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81176921
112CTCF_27219007_Chip-Seq_Bcells_Human0.81047414
113JUN_21703547_ChIP-Seq_K562_Human0.80828435
114ZFP281_27345836_Chip-Seq_ESCs_Mouse0.80702056
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80319918
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79540461
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79540461
118REST_19997604_ChIP-ChIP_NEURONS_Mouse0.74056741
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.73841624
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.71501550
121* POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.71397062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.47773423
2MP0003880_abnormal_central_pattern4.60014446
3MP0003635_abnormal_synaptic_transmissio4.15417878
4MP0004270_analgesia3.94150491
5MP0002063_abnormal_learning/memory/cond3.26606185
6MP0009745_abnormal_behavioral_response3.26303712
7MP0002064_seizures3.13755651
8MP0001968_abnormal_touch/_nociception3.13383193
9MP0005423_abnormal_somatic_nervous2.93120889
10MP0009046_muscle_twitch2.91901076
11MP0002734_abnormal_mechanical_nocicepti2.74670531
12MP0002572_abnormal_emotion/affect_behav2.70942457
13MP0001486_abnormal_startle_reflex2.52055334
14MP0002272_abnormal_nervous_system2.51253040
15MP0002735_abnormal_chemical_nociception2.39883604
16MP0003329_amyloid_beta_deposits2.38337175
17MP0002736_abnormal_nociception_after2.36084902
18MP0002733_abnormal_thermal_nociception2.30184047
19MP0004858_abnormal_nervous_system2.20276682
20MP0009780_abnormal_chondrocyte_physiolo2.14833082
21MP0001501_abnormal_sleep_pattern2.12930930
22MP0001970_abnormal_pain_threshold2.09830209
23MP0001440_abnormal_grooming_behavior2.09027482
24MP0002822_catalepsy2.07909090
25MP0002067_abnormal_sensory_capabilities1.94860897
26MP0000778_abnormal_nervous_system1.94306786
27MP0004811_abnormal_neuron_physiology1.93396659
28MP0002909_abnormal_adrenal_gland1.90430226
29MP0006276_abnormal_autonomic_nervous1.88692083
30MP0008569_lethality_at_weaning1.87621456
31MP0002184_abnormal_innervation1.84595784
32MP0005386_behavior/neurological_phenoty1.76040811
33MP0004924_abnormal_behavior1.76040811
34MP0002557_abnormal_social/conspecific_i1.75973989
35MP0000955_abnormal_spinal_cord1.68500422
36MP0004885_abnormal_endolymph1.60659508
37MP0002882_abnormal_neuron_morphology1.50018404
38MP0001984_abnormal_olfaction1.48932892
39MP0005646_abnormal_pituitary_gland1.45318612
40MP0002066_abnormal_motor_capabilities/c1.45018760
41MP0003633_abnormal_nervous_system1.42591794
42MP0005645_abnormal_hypothalamus_physiol1.39023525
43MP0003879_abnormal_hair_cell1.36983015
44MP0002653_abnormal_ependyma_morphology1.33557042
45MP0001529_abnormal_vocalization1.33003558
46MP0003122_maternal_imprinting1.32936111
47MP0001502_abnormal_circadian_rhythm1.26946227
48MP0001905_abnormal_dopamine_level1.24117132
49MP0008961_abnormal_basal_metabolism1.22274756
50MP0004142_abnormal_muscle_tone1.21216626
51MP0003631_nervous_system_phenotype1.20677270
52MP0000569_abnormal_digit_pigmentation1.18664827
53MP0000604_amyloidosis1.16540490
54MP0002152_abnormal_brain_morphology1.15912630
55MP0003690_abnormal_glial_cell1.13441061
56MP0003121_genomic_imprinting1.09914342
57MP0004147_increased_porphyrin_level1.09586837
58MP0000013_abnormal_adipose_tissue1.08432656
59MP0003634_abnormal_glial_cell1.08189815
60MP0000920_abnormal_myelination1.07332844
61MP0002229_neurodegeneration1.07192155
62MP0003787_abnormal_imprinting1.01268095
63MP0004233_abnormal_muscle_weight0.99471474
64MP0003283_abnormal_digestive_organ0.99288596
65MP0002069_abnormal_eating/drinking_beha0.96331104
66MP0005551_abnormal_eye_electrophysiolog0.92835388
67MP0003632_abnormal_nervous_system0.90987270
68MP0008877_abnormal_DNA_methylation0.89505404
69MP0000751_myopathy0.88004173
70MP0003172_abnormal_lysosome_physiology0.86923741
71MP0008872_abnormal_physiological_respon0.86065363
72MP0004742_abnormal_vestibular_system0.85895772
73MP0005535_abnormal_body_temperature0.85470531
74MP0003075_altered_response_to0.84893803
75MP0002090_abnormal_vision0.83147212
76MP0008874_decreased_physiological_sensi0.82417282
77MP0001177_atelectasis0.79883046
78MP0002752_abnormal_somatic_nervous0.79020532
79MP0001188_hyperpigmentation0.77812541
80MP0005167_abnormal_blood-brain_barrier0.74738406
81MP0004085_abnormal_heartbeat0.74575630
82MP0001963_abnormal_hearing_physiology0.74401370
83MP0000631_abnormal_neuroendocrine_gland0.74239596
84MP0001986_abnormal_taste_sensitivity0.73909967
85MP0004145_abnormal_muscle_electrophysio0.73825158
86MP0010386_abnormal_urinary_bladder0.73794930
87MP0001299_abnormal_eye_distance/0.72857415
88MP0005394_taste/olfaction_phenotype0.71194754
89MP0005499_abnormal_olfactory_system0.71194754
90MP0004130_abnormal_muscle_cell0.70069145
91MP0008260_abnormal_autophagy0.70068673
92MP0005623_abnormal_meninges_morphology0.69001083
93MP0010234_abnormal_vibrissa_follicle0.66827109
94MP0003938_abnormal_ear_development0.66356993
95MP0000026_abnormal_inner_ear0.66196629
96MP0001485_abnormal_pinna_reflex0.63534939
97MP0003123_paternal_imprinting0.62013216
98MP0002837_dystrophic_cardiac_calcinosis0.61859747
99MP0002638_abnormal_pupillary_reflex0.61739997
100MP0003861_abnormal_nervous_system0.61274217
101MP0002102_abnormal_ear_morphology0.60827723
102MP0001664_abnormal_digestion0.60751934
103MP0001348_abnormal_lacrimal_gland0.60619661
104MP0003137_abnormal_impulse_conducting0.58807701
105MP0004043_abnormal_pH_regulation0.58143086
106MP0001943_abnormal_respiration0.57462223
107MP0000747_muscle_weakness0.56626707
108MP0004215_abnormal_myocardial_fiber0.56226576
109MP0010768_mortality/aging0.55711449
110MP0002082_postnatal_lethality0.55651295
111MP0010769_abnormal_survival0.55008241
112MP0005187_abnormal_penis_morphology0.53626915
113MP0010770_preweaning_lethality0.53268649
114MP0008789_abnormal_olfactory_epithelium0.52293914
115MP0003956_abnormal_body_size0.51989187
116MP0005253_abnormal_eye_physiology0.51724017
117MP0002751_abnormal_autonomic_nervous0.51609693
118MP0001346_abnormal_lacrimal_gland0.46805850
119MP0002081_perinatal_lethality0.45780395

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.57702747
2Myokymia (HP:0002411)6.36662040
3Focal seizures (HP:0007359)5.35797024
4Visual hallucinations (HP:0002367)5.23547859
5Supranuclear gaze palsy (HP:0000605)4.38365954
6Epileptic encephalopathy (HP:0200134)4.25700831
7Mutism (HP:0002300)4.14761255
8Progressive cerebellar ataxia (HP:0002073)3.97088007
9Action tremor (HP:0002345)3.96424623
10Ankle clonus (HP:0011448)3.94092100
11Atonic seizures (HP:0010819)3.86611598
12Absence seizures (HP:0002121)3.83722141
13Papilledema (HP:0001085)3.71704115
14Generalized tonic-clonic seizures (HP:0002069)3.60611582
15Dialeptic seizures (HP:0011146)3.54421889
16Neurofibrillary tangles (HP:0002185)3.53506375
17Febrile seizures (HP:0002373)3.47827739
18Cerebral inclusion bodies (HP:0100314)3.32479285
19Depression (HP:0000716)3.29095778
20Abnormal eating behavior (HP:0100738)3.23928727
21Poor eye contact (HP:0000817)3.14829880
22Impaired vibration sensation in the lower limbs (HP:0002166)3.09506447
23Urinary bladder sphincter dysfunction (HP:0002839)3.06506194
24Truncal ataxia (HP:0002078)3.02170294
25Dysmetria (HP:0001310)3.01282458
26Broad-based gait (HP:0002136)3.00960578
27Urinary urgency (HP:0000012)2.96917535
28Split foot (HP:0001839)2.96729950
29Postural instability (HP:0002172)2.96054025
30Cerebral hypomyelination (HP:0006808)2.96042718
31Termporal pattern (HP:0011008)2.90729586
32Insidious onset (HP:0003587)2.90729586
33Impaired social interactions (HP:0000735)2.90191683
34Abnormal social behavior (HP:0012433)2.90191683
35Anxiety (HP:0000739)2.86093696
36Dysdiadochokinesis (HP:0002075)2.84186344
37Spastic gait (HP:0002064)2.81856444
38Megalencephaly (HP:0001355)2.81674603
39Pheochromocytoma (HP:0002666)2.79517790
40Delusions (HP:0000746)2.78386997
41Polyphagia (HP:0002591)2.77566045
42Agitation (HP:0000713)2.75088656
43Drooling (HP:0002307)2.74921823
44Excessive salivation (HP:0003781)2.74921823
45Abnormality of the corticospinal tract (HP:0002492)2.66984534
46Hyperventilation (HP:0002883)2.66589231
47Progressive inability to walk (HP:0002505)2.65929516
48Genetic anticipation (HP:0003743)2.65390904
49Torticollis (HP:0000473)2.65018954
50Gaze-evoked nystagmus (HP:0000640)2.63676064
51Abnormality of binocular vision (HP:0011514)2.62195958
52Diplopia (HP:0000651)2.62195958
53Intention tremor (HP:0002080)2.61109793
54Sleep apnea (HP:0010535)2.54813461
55Amblyopia (HP:0000646)2.51076090
56Tetraplegia (HP:0002445)2.50161378
57Limb dystonia (HP:0002451)2.48923276
58Gait imbalance (HP:0002141)2.48728034
59Hemiparesis (HP:0001269)2.46982698
60Stereotypic behavior (HP:0000733)2.45251624
61Focal dystonia (HP:0004373)2.42540469
62Scanning speech (HP:0002168)2.42044853
63Bradykinesia (HP:0002067)2.41035290
64Epileptiform EEG discharges (HP:0011182)2.40819481
65Spastic tetraplegia (HP:0002510)2.40135047
66Lower limb muscle weakness (HP:0007340)2.38146790
67Apathy (HP:0000741)2.38004910
68Abnormality of the lower motor neuron (HP:0002366)2.37403345
69EEG with generalized epileptiform discharges (HP:0011198)2.37369771
70Neuroendocrine neoplasm (HP:0100634)2.36843555
71Neuronal loss in central nervous system (HP:0002529)2.35284480
72Impaired smooth pursuit (HP:0007772)2.35064783
73Amyotrophic lateral sclerosis (HP:0007354)2.32383963
74Insomnia (HP:0100785)2.32214549
75Hemiplegia (HP:0002301)2.29307549
76Hypsarrhythmia (HP:0002521)2.28535016
77Inappropriate behavior (HP:0000719)2.27547432
78Generalized myoclonic seizures (HP:0002123)2.23635318
79Cortical dysplasia (HP:0002539)2.23321480
80Craniofacial dystonia (HP:0012179)2.20532805
81Rapidly progressive (HP:0003678)2.17859793
82CNS hypomyelination (HP:0003429)2.16981974
83Retinal dysplasia (HP:0007973)2.16734484
84Hammertoe (HP:0001765)2.15565310
85Specific learning disability (HP:0001328)2.15161416
86Absent speech (HP:0001344)2.13705232
87Diminished motivation (HP:0000745)2.12469961
88Ventricular fibrillation (HP:0001663)2.10368140
89Abnormality of ocular smooth pursuit (HP:0000617)2.09717466
90Hypoplasia of the corpus callosum (HP:0002079)2.09706368
91Annular pancreas (HP:0001734)2.09599296
92Clonus (HP:0002169)2.07519881
93Hand muscle atrophy (HP:0009130)2.06429522
94Akinesia (HP:0002304)2.06047762
95Inability to walk (HP:0002540)2.04851968
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.04701706
97Atrophy/Degeneration involving motor neurons (HP:0007373)2.03531302
98Pointed chin (HP:0000307)2.00421592
99Status epilepticus (HP:0002133)1.98221957
100Spastic tetraparesis (HP:0001285)1.97111474
101Neoplasm of the peripheral nervous system (HP:0100007)1.97034636
102Fetal akinesia sequence (HP:0001989)1.96275398
103Impaired vibratory sensation (HP:0002495)1.96160242
104Choreoathetosis (HP:0001266)1.94644678
105Heterochromia iridis (HP:0001100)1.94609800
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91761615
107Paraplegia (HP:0010550)1.90710561
108Lissencephaly (HP:0001339)1.89667000
109Rigidity (HP:0002063)1.86323476
110Psychosis (HP:0000709)1.86062826
111Obstructive sleep apnea (HP:0002870)1.85684665
112Gait ataxia (HP:0002066)1.84061735
113Spastic paraplegia (HP:0001258)1.83578873
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81067378
115Degeneration of the lateral corticospinal tracts (HP:0002314)1.80831248
116Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80831248
117Abnormality of salivation (HP:0100755)1.79661419
118Hypoplasia of the brainstem (HP:0002365)1.77443970
119Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77443970
120Hypoventilation (HP:0002791)1.75686090
121Peripheral hypomyelination (HP:0007182)1.75647458
122Failure to thrive in infancy (HP:0001531)1.74851377
123Ankyloglossia (HP:0010296)1.74658067
124Morphological abnormality of the pyramidal tract (HP:0002062)1.72135598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.37226899
2NTRK34.14859639
3MARK13.82168145
4EPHA43.42575162
5MINK12.94196090
6MAP3K42.85230831
7PAK62.41390676
8KSR22.38740557
9MAP2K72.24122280
10NTRK12.23500512
11NTRK22.18748262
12DAPK22.10854326
13MAP3K121.89253056
14MAP2K41.89141280
15PRKD31.84657079
16CAMKK11.81433288
17BCR1.76302804
18KSR11.75560561
19CDK51.59578619
20RIPK41.56046552
21LATS21.55151712
22PLK21.47415601
23CDK191.44345237
24PHKG21.41140509
25PHKG11.41140509
26MAP3K21.37168018
27UHMK11.34039435
28PNCK1.33674892
29MAPK131.32789600
30MAP4K21.30713149
31TESK11.29879553
32DAPK11.25178614
33BMPR21.23944690
34TYRO31.21483592
35TNIK1.20927298
36ARAF1.17204600
37RET1.16807387
38GRK51.16616889
39LMTK21.16610026
40DYRK21.14905875
41SIK21.13658258
42STK381.12019838
43CSNK1G31.08449807
44CDK141.08159150
45TAOK11.07758866
46PRKCG1.05693614
47CAMKK21.03977437
48FES1.03580899
49PAK31.02824157
50CSNK1A1L1.02679283
51CDK181.01357584
52CDK151.00041322
53TRIM280.99299122
54MAP3K130.97370321
55SCYL20.88440058
56OXSR10.88161618
57CSNK1G20.87700477
58CDK11A0.87191332
59CAMK2A0.86473077
60PRKCH0.84438884
61ALK0.84276694
62MARK20.82703744
63STK110.82648418
64CASK0.82588552
65DMPK0.81143650
66SGK2230.79553312
67SGK4940.79553312
68TESK20.79489037
69RAF10.76874139
70PRPF4B0.76555266
71CAMK10.74342999
72CAMK1G0.73863553
73CSNK1G10.72169687
74MAP3K110.70671207
75CAMK2B0.67523122
76PKN10.67467467
77CAMK40.66322468
78SIK30.65928040
79MAP3K10.63537059
80DYRK1A0.63033359
81WNK10.62009713
82PDK10.61151206
83PDPK10.56702308
84DYRK1B0.55586834
85CCNB10.54326686
86PTK2B0.53858995
87PRKCZ0.53630228
88SGK10.53127056
89SGK30.52821370
90LIMK10.52220038
91WNK30.51824366
92RIPK10.49435323
93MAPK100.49163297
94FER0.49055235
95FYN0.48915986
96MAP2K10.47665096
97BCKDK0.46817157
98TNK20.46728959
99STK390.46652705
100NEK10.46199821
101ERBB30.45895149
102FGFR20.45521974
103PINK10.43345500
104EPHA30.42882816
105RPS6KA30.42611257
106WNK40.42241181
107TSSK60.42117960
108ROCK20.41225227
109SGK20.40610938
110MAP3K50.39680532
111PRKCE0.39508003
112FGR0.38885555
113CAMK2D0.38426855
114MAP3K70.38352437
115RPS6KA20.38125986
116MAPK120.38080999
117BRSK10.37467258
118MAPKAPK50.37296595
119CAMK2G0.36497909
120NEK60.36279366
121JAK20.34829159
122MAP3K60.33370753
123CDC42BPA0.32249710
124EPHB10.31400830
125ERBB20.29307066

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.31244689
2Synaptic vesicle cycle_Homo sapiens_hsa047213.22575653
3GABAergic synapse_Homo sapiens_hsa047272.58827541
4Olfactory transduction_Homo sapiens_hsa047402.52991523
5Circadian entrainment_Homo sapiens_hsa047132.49906463
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.49010435
7Long-term potentiation_Homo sapiens_hsa047202.48925212
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44226079
9Glutamatergic synapse_Homo sapiens_hsa047242.39528159
10Morphine addiction_Homo sapiens_hsa050322.28387314
11Amphetamine addiction_Homo sapiens_hsa050312.23407887
12Dopaminergic synapse_Homo sapiens_hsa047282.14758528
13Salivary secretion_Homo sapiens_hsa049702.06264951
14Insulin secretion_Homo sapiens_hsa049111.97730975
15Gastric acid secretion_Homo sapiens_hsa049711.87968665
16Cholinergic synapse_Homo sapiens_hsa047251.86624643
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73773780
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69410533
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66592343
20Renin secretion_Homo sapiens_hsa049241.62777453
21Cocaine addiction_Homo sapiens_hsa050301.61926806
22Long-term depression_Homo sapiens_hsa047301.59900413
23Serotonergic synapse_Homo sapiens_hsa047261.57829882
24Taste transduction_Homo sapiens_hsa047421.57305207
25Oxytocin signaling pathway_Homo sapiens_hsa049211.53970431
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52226743
27GnRH signaling pathway_Homo sapiens_hsa049121.43607992
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38314213
29Gap junction_Homo sapiens_hsa045401.37246380
30Calcium signaling pathway_Homo sapiens_hsa040201.36166668
31Collecting duct acid secretion_Homo sapiens_hsa049661.29652903
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26848009
33Axon guidance_Homo sapiens_hsa043601.23317622
34Estrogen signaling pathway_Homo sapiens_hsa049151.21519478
35Glioma_Homo sapiens_hsa052141.20321556
36Nitrogen metabolism_Homo sapiens_hsa009101.19850796
37cAMP signaling pathway_Homo sapiens_hsa040241.18206654
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17308772
39Type II diabetes mellitus_Homo sapiens_hsa049301.15298769
40ErbB signaling pathway_Homo sapiens_hsa040121.10046213
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04624199
42Melanogenesis_Homo sapiens_hsa049161.03103951
43Dorso-ventral axis formation_Homo sapiens_hsa043201.00440166
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98976215
45Vitamin B6 metabolism_Homo sapiens_hsa007500.98273239
46Vibrio cholerae infection_Homo sapiens_hsa051100.97170970
47Oocyte meiosis_Homo sapiens_hsa041140.94833158
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94619551
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.87950145
50Pancreatic secretion_Homo sapiens_hsa049720.86156645
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.85224898
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84113736
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84025580
54Thyroid hormone synthesis_Homo sapiens_hsa049180.82486335
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82167571
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82069821
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.80478755
58VEGF signaling pathway_Homo sapiens_hsa043700.80331529
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79540199
60Cardiac muscle contraction_Homo sapiens_hsa042600.79209904
61Choline metabolism in cancer_Homo sapiens_hsa052310.77116125
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75571120
63Phototransduction_Homo sapiens_hsa047440.73570238
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73349498
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72910128
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71997521
67MAPK signaling pathway_Homo sapiens_hsa040100.70753818
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.70698382
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66400525
70Regulation of autophagy_Homo sapiens_hsa041400.66347201
71Endocytosis_Homo sapiens_hsa041440.62580302
72Endometrial cancer_Homo sapiens_hsa052130.62313821
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62003690
74Renal cell carcinoma_Homo sapiens_hsa052110.60497950
75AMPK signaling pathway_Homo sapiens_hsa041520.59492655
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58978848
77mTOR signaling pathway_Homo sapiens_hsa041500.58583062
78Dilated cardiomyopathy_Homo sapiens_hsa054140.58394233
79Ras signaling pathway_Homo sapiens_hsa040140.57451042
80Glucagon signaling pathway_Homo sapiens_hsa049220.57091826
81Bile secretion_Homo sapiens_hsa049760.55522413
82Rap1 signaling pathway_Homo sapiens_hsa040150.52794853
83beta-Alanine metabolism_Homo sapiens_hsa004100.52234914
84Non-small cell lung cancer_Homo sapiens_hsa052230.51679726
85Arginine and proline metabolism_Homo sapiens_hsa003300.50478830
86Prion diseases_Homo sapiens_hsa050200.50205053
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49913559
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49275390
89Insulin signaling pathway_Homo sapiens_hsa049100.48752719
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48691493
91Inositol phosphate metabolism_Homo sapiens_hsa005620.47069309
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46317509
93Alcoholism_Homo sapiens_hsa050340.45689667
94Fatty acid biosynthesis_Homo sapiens_hsa000610.45555064
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45502297
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45223210
97Colorectal cancer_Homo sapiens_hsa052100.45036981
98Wnt signaling pathway_Homo sapiens_hsa043100.43969162
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39676787
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38781543
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37053853
102Ovarian steroidogenesis_Homo sapiens_hsa049130.36351923
103Phagosome_Homo sapiens_hsa041450.36168479
104Steroid biosynthesis_Homo sapiens_hsa001000.35983213
105Chemokine signaling pathway_Homo sapiens_hsa040620.35598023
106Butanoate metabolism_Homo sapiens_hsa006500.35032371
107Salmonella infection_Homo sapiens_hsa051320.34769969
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34600433
109Circadian rhythm_Homo sapiens_hsa047100.34410470
110Type I diabetes mellitus_Homo sapiens_hsa049400.32573723
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31691031
112Fatty acid elongation_Homo sapiens_hsa000620.31259395
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31048379
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.29422403
115Biosynthesis of amino acids_Homo sapiens_hsa012300.28169602
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28063738
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27807549
118Alzheimers disease_Homo sapiens_hsa050100.27749149
119Hippo signaling pathway_Homo sapiens_hsa043900.25931456

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