RTN3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)8.39332866
2regulation of male gonad development (GO:2000018)6.63591209
3protein neddylation (GO:0045116)5.55122297
4indolalkylamine metabolic process (GO:0006586)5.09196270
5dopaminergic neuron differentiation (GO:0071542)4.53574549
6cellular biogenic amine biosynthetic process (GO:0042401)4.01389594
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.88029685
8sequestering of actin monomers (GO:0042989)3.85228110
9amine biosynthetic process (GO:0009309)3.71777483
10indole-containing compound metabolic process (GO:0042430)3.71083398
11phosphatidylglycerol biosynthetic process (GO:0006655)3.67117527
12establishment of mitochondrion localization (GO:0051654)3.65129294
13pyrimidine nucleobase catabolic process (GO:0006208)3.62585169
14otic vesicle formation (GO:0030916)3.56585841
15protein-cofactor linkage (GO:0018065)3.51029555
16viral transcription (GO:0019083)3.46366083
17parturition (GO:0007567)3.43765474
18translational termination (GO:0006415)3.36374196
19acrosome reaction (GO:0007340)3.34016662
20limb bud formation (GO:0060174)3.25544412
21central nervous system neuron development (GO:0021954)3.20368150
22midbrain development (GO:0030901)3.17185958
23transmission of nerve impulse (GO:0019226)3.15135189
24regulation of synapse structural plasticity (GO:0051823)3.13994935
25glycerophospholipid catabolic process (GO:0046475)3.13903319
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.12387187
27maturation of SSU-rRNA (GO:0030490)3.11033744
28primitive streak formation (GO:0090009)3.11002063
29cell proliferation in forebrain (GO:0021846)3.09785702
30cysteine metabolic process (GO:0006534)3.08305738
31inner ear receptor cell development (GO:0060119)3.07648899
32neuron fate determination (GO:0048664)3.06053119
33regulation of action potential (GO:0098900)3.03577756
34protein complex biogenesis (GO:0070271)3.02563149
35negative regulation of catecholamine secretion (GO:0033604)3.02457087
36positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.00664470
37axonal fasciculation (GO:0007413)3.00145408
38regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96400660
39negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95655730
40mitochondrial respiratory chain complex I assembly (GO:0032981)2.91413123
41NADH dehydrogenase complex assembly (GO:0010257)2.91413123
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91413123
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90716580
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90716580
45positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.89751702
46nucleobase catabolic process (GO:0046113)2.87316571
47positive regulation of gastrulation (GO:2000543)2.85863449
48negative regulation of potassium ion transmembrane transport (GO:1901380)2.85200708
49mitochondrion transport along microtubule (GO:0047497)2.83432994
50establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.83432994
51negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.83258833
52brown fat cell differentiation (GO:0050873)2.81789490
53mechanosensory behavior (GO:0007638)2.80459668
54axonemal dynein complex assembly (GO:0070286)2.80404325
55cotranslational protein targeting to membrane (GO:0006613)2.80183040
56DNA damage response, detection of DNA damage (GO:0042769)2.79057984
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.78077496
58protein targeting to ER (GO:0045047)2.75288930
59DNA methylation involved in gamete generation (GO:0043046)2.74798780
60auditory behavior (GO:0031223)2.74639213
61lateral sprouting from an epithelium (GO:0060601)2.74613932
62protein localization to cilium (GO:0061512)2.74025158
63regulation of respiratory system process (GO:0044065)2.73237143
64substrate-independent telencephalic tangential migration (GO:0021826)2.72976908
65substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.72976908
66establishment of protein localization to mitochondrial membrane (GO:0090151)2.72308975
67primary amino compound metabolic process (GO:1901160)2.72032350
68forebrain morphogenesis (GO:0048853)2.71535365
69gamma-aminobutyric acid transport (GO:0015812)2.70512948
70cochlea development (GO:0090102)2.69282295
71inner mitochondrial membrane organization (GO:0007007)2.69149185
72negative regulation of DNA biosynthetic process (GO:2000279)2.67991486
73establishment of protein localization to endoplasmic reticulum (GO:0072599)2.67443152
74response to parathyroid hormone (GO:0071107)2.67316098
75proton transport (GO:0015992)2.65162826
76cerebral cortex radially oriented cell migration (GO:0021799)2.63748071
77negative regulation of dendrite development (GO:2000171)2.63385233
78negative regulation of axon guidance (GO:1902668)2.62045802
79forebrain neuron development (GO:0021884)2.61860467
80cellular protein complex disassembly (GO:0043624)2.61153436
81positive regulation of RNA splicing (GO:0033120)2.60613120
82retinal ganglion cell axon guidance (GO:0031290)2.60579186
83hydrogen transport (GO:0006818)2.59143456
84behavioral response to ethanol (GO:0048149)2.58457943
85presynaptic membrane organization (GO:0097090)2.58440622
86negative regulation of transcription regulatory region DNA binding (GO:2000678)2.58408499
87viral protein processing (GO:0019082)2.58182499
88phosphorelay signal transduction system (GO:0000160)2.56968154
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56172452
90regulation of gonadotropin secretion (GO:0032276)2.55932463
91viral life cycle (GO:0019058)2.55635566
92nonmotile primary cilium assembly (GO:0035058)2.55379468
93mitochondrial respiratory chain complex assembly (GO:0033108)2.55319940
94protein localization to endoplasmic reticulum (GO:0070972)2.54648289
95ATP synthesis coupled proton transport (GO:0015986)2.53931868
96energy coupled proton transport, down electrochemical gradient (GO:0015985)2.53931868
97response to nicotine (GO:0035094)2.53753907
98dendritic spine morphogenesis (GO:0060997)2.52947526
99positive regulation of DNA-templated transcription, initiation (GO:2000144)2.51349723
100translational elongation (GO:0006414)2.51126738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.19095787
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.92213778
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.15662292
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.03588652
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96080951
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.91410231
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.82383788
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53370761
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.42684848
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.37109669
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.27259622
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20202211
13ZNF274_21170338_ChIP-Seq_K562_Hela2.17145832
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11736782
15VDR_22108803_ChIP-Seq_LS180_Human2.08458315
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03271022
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.94340161
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93864859
19GBX2_23144817_ChIP-Seq_PC3_Human1.90141342
20FUS_26573619_Chip-Seq_HEK293_Human1.89373209
21RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.87658168
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85311531
23REST_21632747_ChIP-Seq_MESCs_Mouse1.79880966
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73433648
25IRF1_19129219_ChIP-ChIP_H3396_Human1.72785781
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68440439
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65068891
28RNF2_27304074_Chip-Seq_NSC_Mouse1.63721655
29P300_19829295_ChIP-Seq_ESCs_Human1.62731338
30AR_21572438_ChIP-Seq_LNCaP_Human1.60644527
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60098210
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59853748
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59853748
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59122908
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57228696
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54926123
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53754537
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52619648
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52619648
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52513274
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49472981
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.47728842
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.47549345
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.47212720
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43258553
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.42682082
47TP53_22573176_ChIP-Seq_HFKS_Human1.40327549
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.38977158
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37454784
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37356545
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32020315
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.31825153
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29610562
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27823078
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26594441
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.24862736
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.24531857
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23842454
59EWS_26573619_Chip-Seq_HEK293_Human1.22228654
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19388970
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16881581
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15985482
63SMAD4_21799915_ChIP-Seq_A2780_Human1.13891278
64TAF15_26573619_Chip-Seq_HEK293_Human1.12721770
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10720530
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09728057
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08648613
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08601303
69TCF4_22108803_ChIP-Seq_LS180_Human1.06965553
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06510452
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.05727222
72BCAT_22108803_ChIP-Seq_LS180_Human1.05366880
73AR_25329375_ChIP-Seq_VCAP_Human1.03861345
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03858483
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01042452
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00715321
77ER_23166858_ChIP-Seq_MCF-7_Human1.00262936
78PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99407437
79NANOG_18555785_Chip-Seq_ESCs_Mouse0.98384984
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96294567
81P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94997157
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94613543
83EST1_17652178_ChIP-ChIP_JURKAT_Human0.93850293
84STAT3_23295773_ChIP-Seq_U87_Human0.93620074
85NANOG_19829295_ChIP-Seq_ESCs_Human0.93222718
86SOX2_19829295_ChIP-Seq_ESCs_Human0.93222718
87RING1B_27294783_Chip-Seq_ESCs_Mouse0.92354759
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91790539
89RUNX2_22187159_ChIP-Seq_PCA_Human0.91300111
90SOX2_21211035_ChIP-Seq_LN229_Gbm0.90638107
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.90315499
92E2F1_18555785_Chip-Seq_ESCs_Mouse0.88426311
93P53_22387025_ChIP-Seq_ESCs_Mouse0.88039815
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87273891
95IGF1R_20145208_ChIP-Seq_DFB_Human0.87192417
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.86717251
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86208708
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85575874
99NCOR_22424771_ChIP-Seq_293T_Human0.84802629
100POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84540941

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.63471329
2MP0004145_abnormal_muscle_electrophysio4.10891645
3MP0003880_abnormal_central_pattern3.15070066
4MP0009379_abnormal_foot_pigmentation2.99701623
5MP0002102_abnormal_ear_morphology2.99076218
6MP0002736_abnormal_nociception_after2.75607567
7MP0005423_abnormal_somatic_nervous2.33643936
8MP0006276_abnormal_autonomic_nervous2.32387448
9MP0003183_abnormal_peptide_metabolism2.32012232
10MP0003122_maternal_imprinting2.19818700
11MP0004142_abnormal_muscle_tone2.18335061
12MP0001188_hyperpigmentation2.10452035
13MP0000778_abnormal_nervous_system2.08413015
14MP0000631_abnormal_neuroendocrine_gland2.05701852
15MP0006292_abnormal_olfactory_placode2.05294099
16MP0002184_abnormal_innervation2.02449948
17MP0002735_abnormal_chemical_nociception2.02312943
18MP0008872_abnormal_physiological_respon2.01457975
19MP0001529_abnormal_vocalization1.98320693
20MP0009046_muscle_twitch1.95348363
21MP0001968_abnormal_touch/_nociception1.92709495
22MP0004147_increased_porphyrin_level1.89541148
23MP0009745_abnormal_behavioral_response1.83955400
24MP0002938_white_spotting1.75491242
25MP0001440_abnormal_grooming_behavior1.72847052
26MP0002063_abnormal_learning/memory/cond1.71905930
27MP0005645_abnormal_hypothalamus_physiol1.71716867
28MP0002822_catalepsy1.69518035
29MP0002272_abnormal_nervous_system1.67892583
30MP0002064_seizures1.67216675
31MP0005646_abnormal_pituitary_gland1.65122310
32MP0004885_abnormal_endolymph1.60708622
33MP0002653_abnormal_ependyma_morphology1.58822503
34MP0002572_abnormal_emotion/affect_behav1.56536947
35MP0000955_abnormal_spinal_cord1.55872836
36MP0003890_abnormal_embryonic-extraembry1.51796732
37MP0001905_abnormal_dopamine_level1.50352293
38MP0005551_abnormal_eye_electrophysiolog1.48037223
39MP0003635_abnormal_synaptic_transmissio1.45393198
40MP0001486_abnormal_startle_reflex1.42161426
41MP0003121_genomic_imprinting1.39970970
42MP0002909_abnormal_adrenal_gland1.32703986
43MP0002557_abnormal_social/conspecific_i1.32406298
44MP0002234_abnormal_pharynx_morphology1.31433402
45MP0002733_abnormal_thermal_nociception1.30594765
46MP0008995_early_reproductive_senescence1.29160558
47MP0002249_abnormal_larynx_morphology1.26670774
48MP0000026_abnormal_inner_ear1.26218074
49MP0003938_abnormal_ear_development1.26022592
50MP0002752_abnormal_somatic_nervous1.25912691
51MP0004270_analgesia1.25693850
52MP0005257_abnormal_intraocular_pressure1.24270327
53MP0002067_abnormal_sensory_capabilities1.19441417
54MP0002734_abnormal_mechanical_nocicepti1.18805089
55MP0002095_abnormal_skin_pigmentation1.18757400
56MP0004133_heterotaxia1.17255656
57MP0002882_abnormal_neuron_morphology1.14318334
58MP0000569_abnormal_digit_pigmentation1.13477317
59MP0000049_abnormal_middle_ear1.13389302
60MP0002751_abnormal_autonomic_nervous1.13279176
61MP0001970_abnormal_pain_threshold1.12263503
62MP0005386_behavior/neurological_phenoty1.09655559
63MP0004924_abnormal_behavior1.09655559
64MP0005084_abnormal_gallbladder_morpholo1.07235727
65MP0002638_abnormal_pupillary_reflex1.04706086
66MP0008875_abnormal_xenobiotic_pharmacok1.03524086
67MP0004811_abnormal_neuron_physiology1.03056209
68MP0002282_abnormal_trachea_morphology1.02597565
69MP0005360_urolithiasis1.01287531
70MP0005670_abnormal_white_adipose0.99357863
71MP0001986_abnormal_taste_sensitivity0.98778231
72MP0003119_abnormal_digestive_system0.96429661
73MP0002837_dystrophic_cardiac_calcinosis0.95525756
74MP0001984_abnormal_olfaction0.92732654
75MP0003186_abnormal_redox_activity0.91688070
76MP0001963_abnormal_hearing_physiology0.89860690
77MP0005448_abnormal_energy_balance0.89841305
78MP0001324_abnormal_eye_pigmentation0.89417014
79MP0005253_abnormal_eye_physiology0.88466778
80MP0002152_abnormal_brain_morphology0.85752329
81MP0002069_abnormal_eating/drinking_beha0.84712387
82MP0008877_abnormal_DNA_methylation0.83779582
83MP0005195_abnormal_posterior_eye0.83704780
84MP0003755_abnormal_palate_morphology0.82416261
85MP0003011_delayed_dark_adaptation0.81716048
86MP0001502_abnormal_circadian_rhythm0.80493330
87MP0002876_abnormal_thyroid_physiology0.79403635
88MP0003937_abnormal_limbs/digits/tail_de0.78842568
89MP0004859_abnormal_synaptic_plasticity0.78295631
90MP0003787_abnormal_imprinting0.76714467
91MP0008789_abnormal_olfactory_epithelium0.76343259
92MP0002160_abnormal_reproductive_system0.75658784
93MP0004134_abnormal_chest_morphology0.75327622
94MP0002066_abnormal_motor_capabilities/c0.75281081
95MP0001485_abnormal_pinna_reflex0.73103321
96MP0001944_abnormal_pancreas_morphology0.72847559
97MP0000537_abnormal_urethra_morphology0.72324312
98MP0003861_abnormal_nervous_system0.71004413
99MP0005499_abnormal_olfactory_system0.70724546
100MP0005394_taste/olfaction_phenotype0.70724546

Predicted human phenotypes

RankGene SetZ-score
1Oligodactyly (hands) (HP:0001180)4.68341066
2Type II lissencephaly (HP:0007260)4.36656698
3Abnormality of the labia minora (HP:0012880)4.11668444
4Retinal dysplasia (HP:0007973)3.93604476
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.28081233
6Abnormality of alanine metabolism (HP:0010916)3.28081233
7Hyperalaninemia (HP:0003348)3.28081233
8Constricted visual fields (HP:0001133)3.18164263
9Decreased electroretinogram (ERG) amplitude (HP:0000654)3.11962783
10Focal motor seizures (HP:0011153)3.10268825
11True hermaphroditism (HP:0010459)3.06286396
12Oligodactyly (HP:0012165)2.95029011
13Limb dystonia (HP:0002451)2.94889248
14Stenosis of the external auditory canal (HP:0000402)2.93201561
15Medial flaring of the eyebrow (HP:0010747)2.92695211
16Polyphagia (HP:0002591)2.92403968
17Septo-optic dysplasia (HP:0100842)2.91869596
18Hip dysplasia (HP:0001385)2.91275338
19Labial hypoplasia (HP:0000066)2.84461765
20Gait imbalance (HP:0002141)2.81557591
21Pancreatic cysts (HP:0001737)2.78728986
22Lissencephaly (HP:0001339)2.78108074
23Intestinal atresia (HP:0011100)2.72782751
24Genital tract atresia (HP:0001827)2.70133235
25Pancreatic fibrosis (HP:0100732)2.69975237
26Abnormality of the phalanges of the 2nd finger (HP:0009541)2.64692812
27Nephrogenic diabetes insipidus (HP:0009806)2.63439852
28Split foot (HP:0001839)2.62556247
29Increased hepatocellular lipid droplets (HP:0006565)2.53993401
30Congenital primary aphakia (HP:0007707)2.51630925
31Hypoplastic female external genitalia (HP:0012815)2.50198244
32Abnormal respiratory motile cilium morphology (HP:0005938)2.50063186
33Abnormal respiratory epithelium morphology (HP:0012253)2.50063186
34Abnormal hair whorl (HP:0010721)2.48764343
35Thyroid-stimulating hormone excess (HP:0002925)2.48167480
36Short tibia (HP:0005736)2.46626507
37Vaginal atresia (HP:0000148)2.45954034
38Pendular nystagmus (HP:0012043)2.45371921
39Oligomenorrhea (HP:0000876)2.43123555
403-Methylglutaconic aciduria (HP:0003535)2.42562473
41Delayed CNS myelination (HP:0002188)2.41990709
42Anencephaly (HP:0002323)2.39226803
43Congenital stationary night blindness (HP:0007642)2.39211228
44Broad-based gait (HP:0002136)2.38853407
45Maternal diabetes (HP:0009800)2.37048991
46Increased corneal curvature (HP:0100692)2.36210121
47Keratoconus (HP:0000563)2.36210121
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.35973013
49Conjugated hyperbilirubinemia (HP:0002908)2.34410769
50Gastrointestinal atresia (HP:0002589)2.28488315
51Lipid accumulation in hepatocytes (HP:0006561)2.25993743
52Abnormal ciliary motility (HP:0012262)2.25071901
53Myokymia (HP:0002411)2.23853500
54Inability to walk (HP:0002540)2.23256275
55Hypoplastic labia majora (HP:0000059)2.13960654
56Mitochondrial inheritance (HP:0001427)2.10403519
57Congenital, generalized hypertrichosis (HP:0004540)2.08773135
58Clumsiness (HP:0002312)2.08608285
59Attenuation of retinal blood vessels (HP:0007843)2.07680795
60Morphological abnormality of the pyramidal tract (HP:0002062)2.06260707
61Congenital sensorineural hearing impairment (HP:0008527)2.05953768
62Growth hormone deficiency (HP:0000824)2.05900839
63Cystic liver disease (HP:0006706)2.05583347
64Poor speech (HP:0002465)2.02027346
65Atonic seizures (HP:0010819)2.01738050
66Pachygyria (HP:0001302)2.01239510
67Epidermoid cyst (HP:0200040)2.01130355
68Macrocytic anemia (HP:0001972)2.00542122
69Male pseudohermaphroditism (HP:0000037)1.96429315
70Focal seizures (HP:0007359)1.95141957
71Optic nerve hypoplasia (HP:0000609)1.94465441
72Abnormal respiratory motile cilium physiology (HP:0012261)1.94444640
73Sleep apnea (HP:0010535)1.94075113
74Abnormality of the labia (HP:0000058)1.93889336
75Athetosis (HP:0002305)1.93222780
76Long nose (HP:0003189)1.93062112
77Reticulocytopenia (HP:0001896)1.92421443
78Abnormality of the labia majora (HP:0012881)1.91709392
79Abnormality of cells of the erythroid lineage (HP:0012130)1.90834748
80Agitation (HP:0000713)1.90592820
81Absent septum pellucidum (HP:0001331)1.90562593
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89086366
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.88568467
84Absent/shortened dynein arms (HP:0200106)1.88568467
85Abnormal number of incisors (HP:0011064)1.86330736
86Heterochromia iridis (HP:0001100)1.84930663
87Spastic tetraplegia (HP:0002510)1.84704386
88Specific learning disability (HP:0001328)1.82318184
89Poor suck (HP:0002033)1.80735323
90Choroideremia (HP:0001139)1.77517932
91Deep palmar crease (HP:0006191)1.75306467
92Ulnar claw (HP:0001178)1.75242080
93Acute encephalopathy (HP:0006846)1.74693109
94Increased CSF lactate (HP:0002490)1.74338731
95Abnormality of midbrain morphology (HP:0002418)1.73789962
96Molar tooth sign on MRI (HP:0002419)1.73789962
97Nephronophthisis (HP:0000090)1.73483630
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72744540
99Generalized myoclonic seizures (HP:0002123)1.72523847
100Acute necrotizing encephalopathy (HP:0006965)1.71985956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.92977046
2MAP4K22.84123132
3NTRK22.78557645
4DYRK22.73813799
5MINK12.61495329
6SGK2232.46379808
7SGK4942.46379808
8PINK12.16474518
9UHMK12.06864009
10CASK1.95546900
11ADRBK21.91006926
12MAPKAPK51.87006064
13MAPK131.86408729
14AKT31.81732249
15MAP3K41.81629022
16PNCK1.68550018
17EPHB21.67843997
18NME11.59646324
19SGK21.56814566
20MAP2K41.56478771
21TNIK1.55470851
22WNK31.52619136
23NTRK31.50414811
24EIF2AK11.47551051
25DAPK21.47122084
26MAP3K121.45517262
27MAP2K71.37601230
28DAPK31.36189229
29PHKG21.35305597
30PHKG11.35305597
31OXSR11.33504949
32PRKCG1.28344679
33WNK11.26467693
34ADRBK11.22527725
35BCKDK1.21030923
36WNK41.20016520
37GRK11.18185601
38GRK71.16563103
39PKN11.16065990
40PAK31.15162465
41FGFR21.12170411
42CDK191.10610576
43MET1.09274099
44DYRK1B1.05218770
45DYRK31.01484509
46BCR1.01031257
47MAP3K111.00763928
48TAOK10.96569351
49CSNK1G20.91062401
50TYRO30.87540305
51CSNK1G10.86551390
52SGK30.83655694
53SGK10.81606509
54CAMK2B0.79848978
55ZAK0.79089449
56CAMK2D0.75608380
57CAMK2A0.74779456
58CSNK1A10.73904802
59INSRR0.73091682
60PRKG10.72047813
61CSNK1G30.71767692
62PRKACA0.69387838
63MAPK150.66122910
64BRD40.62280930
65STK390.62125350
66CSF1R0.60474424
67MAP3K50.60276280
68PRKCE0.60217193
69DYRK1A0.60009500
70FRK0.59550427
71CDK50.58480226
72CSNK1A1L0.57953075
73MAP3K60.57848372
74PRKCZ0.57257059
75ROCK10.56336006
76PRKCD0.55160830
77PRKCQ0.53946670
78AURKA0.52749792
79NUAK10.52399243
80CAMK2G0.51933353
81EGFR0.49361516
82TRIM280.49155993
83PASK0.48509647
84RPS6KA60.46428898
85PRKCH0.46219268
86RPS6KA10.46035966
87PTK2B0.43109307
88RPS6KB10.41979155
89FYN0.41210477
90RPS6KA50.40693758
91MAP3K30.40642021
92PRKACB0.39251207
93LIMK10.38693852
94CSNK1E0.38611823
95CAMK10.37141878
96OBSCN0.35853421
97EIF2AK30.35284596
98RPS6KA30.34544354
99PRKACG0.32896259
100RPS6KA20.32302883

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.54411083
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.41292626
3Ribosome_Homo sapiens_hsa030103.24393675
4Nicotine addiction_Homo sapiens_hsa050333.13838094
5Parkinsons disease_Homo sapiens_hsa050122.91358769
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.85949459
7Protein export_Homo sapiens_hsa030602.67897140
8Cardiac muscle contraction_Homo sapiens_hsa042602.50475567
9Basal transcription factors_Homo sapiens_hsa030222.31583599
10Tryptophan metabolism_Homo sapiens_hsa003802.27572769
11Phototransduction_Homo sapiens_hsa047442.14651091
12Linoleic acid metabolism_Homo sapiens_hsa005912.12614756
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.02883951
14Alzheimers disease_Homo sapiens_hsa050102.00168441
15Morphine addiction_Homo sapiens_hsa050321.96444128
16Collecting duct acid secretion_Homo sapiens_hsa049661.95964100
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94368606
18Huntingtons disease_Homo sapiens_hsa050161.93718990
19GABAergic synapse_Homo sapiens_hsa047271.87700571
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85349907
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73165268
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67795698
23Circadian entrainment_Homo sapiens_hsa047131.60097707
24Olfactory transduction_Homo sapiens_hsa047401.54353124
25Synaptic vesicle cycle_Homo sapiens_hsa047211.52881298
26Selenocompound metabolism_Homo sapiens_hsa004501.49797977
27Sulfur metabolism_Homo sapiens_hsa009201.44949618
28Dopaminergic synapse_Homo sapiens_hsa047281.37085623
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35729494
30Glutamatergic synapse_Homo sapiens_hsa047241.32310759
31Regulation of autophagy_Homo sapiens_hsa041401.31385913
32Serotonergic synapse_Homo sapiens_hsa047261.31371980
33Butanoate metabolism_Homo sapiens_hsa006501.30432969
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.16382966
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15345137
36Taste transduction_Homo sapiens_hsa047421.14570094
37Insulin secretion_Homo sapiens_hsa049111.13910232
38Basal cell carcinoma_Homo sapiens_hsa052171.07850264
39Proteasome_Homo sapiens_hsa030501.06957969
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06536440
41Hedgehog signaling pathway_Homo sapiens_hsa043401.05978959
42One carbon pool by folate_Homo sapiens_hsa006700.96778621
43Nitrogen metabolism_Homo sapiens_hsa009100.94514559
44Ether lipid metabolism_Homo sapiens_hsa005650.93546916
45Cocaine addiction_Homo sapiens_hsa050300.93314235
46Cholinergic synapse_Homo sapiens_hsa047250.91354103
47Axon guidance_Homo sapiens_hsa043600.89498827
48Long-term depression_Homo sapiens_hsa047300.89291925
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89186446
50Amphetamine addiction_Homo sapiens_hsa050310.85627752
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.85025129
52Spliceosome_Homo sapiens_hsa030400.84740276
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84563427
54RNA degradation_Homo sapiens_hsa030180.83878453
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78599023
56Chemical carcinogenesis_Homo sapiens_hsa052040.76651125
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75895774
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72610201
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72003809
60Alcoholism_Homo sapiens_hsa050340.71148706
61Salivary secretion_Homo sapiens_hsa049700.68589200
62Retinol metabolism_Homo sapiens_hsa008300.66337703
63Propanoate metabolism_Homo sapiens_hsa006400.65623569
64Peroxisome_Homo sapiens_hsa041460.63165914
65Vibrio cholerae infection_Homo sapiens_hsa051100.60855053
66Ovarian steroidogenesis_Homo sapiens_hsa049130.60702254
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58985684
68Arachidonic acid metabolism_Homo sapiens_hsa005900.58056158
69Caffeine metabolism_Homo sapiens_hsa002320.50948078
70Circadian rhythm_Homo sapiens_hsa047100.48910536
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48468583
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48248553
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46806973
74Arginine biosynthesis_Homo sapiens_hsa002200.46800629
75Tyrosine metabolism_Homo sapiens_hsa003500.46632036
76Ras signaling pathway_Homo sapiens_hsa040140.44784845
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44272950
78Melanogenesis_Homo sapiens_hsa049160.43160039
79Calcium signaling pathway_Homo sapiens_hsa040200.41684547
80Renin secretion_Homo sapiens_hsa049240.41194323
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40903838
82cAMP signaling pathway_Homo sapiens_hsa040240.39761556
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38547187
84Glycerolipid metabolism_Homo sapiens_hsa005610.37476352
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37304607
86Metabolic pathways_Homo sapiens_hsa011000.37114501
87Starch and sucrose metabolism_Homo sapiens_hsa005000.36120700
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35851446
89Type II diabetes mellitus_Homo sapiens_hsa049300.33677961
90Gap junction_Homo sapiens_hsa045400.30709733
91Fanconi anemia pathway_Homo sapiens_hsa034600.29494124
92Vitamin digestion and absorption_Homo sapiens_hsa049770.27671870
93Gastric acid secretion_Homo sapiens_hsa049710.27631861
94Wnt signaling pathway_Homo sapiens_hsa043100.26811868
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.26007988
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25063624
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24675607
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24079517
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23954198
100Steroid biosynthesis_Homo sapiens_hsa001000.23762409

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