ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	8.39332866
2	regulation of male gonad development (GO:2000018)	6.63591209
3	protein neddylation (GO:0045116)	5.55122297
4	indolalkylamine metabolic process (GO:0006586)	5.09196270
5	dopaminergic neuron differentiation (GO:0071542)	4.53574549
6	cellular biogenic amine biosynthetic process (GO:0042401)	4.01389594
7	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.88029685
8	sequestering of actin monomers (GO:0042989)	3.85228110
9	amine biosynthetic process (GO:0009309)	3.71777483
10	indole-containing compound metabolic process (GO:0042430)	3.71083398
11	phosphatidylglycerol biosynthetic process (GO:0006655)	3.67117527
12	establishment of mitochondrion localization (GO:0051654)	3.65129294
13	pyrimidine nucleobase catabolic process (GO:0006208)	3.62585169
14	otic vesicle formation (GO:0030916)	3.56585841
15	protein-cofactor linkage (GO:0018065)	3.51029555
16	viral transcription (GO:0019083)	3.46366083
17	parturition (GO:0007567)	3.43765474
18	translational termination (GO:0006415)	3.36374196
19	acrosome reaction (GO:0007340)	3.34016662
20	limb bud formation (GO:0060174)	3.25544412
21	central nervous system neuron development (GO:0021954)	3.20368150
22	midbrain development (GO:0030901)	3.17185958
23	transmission of nerve impulse (GO:0019226)	3.15135189
24	regulation of synapse structural plasticity (GO:0051823)	3.13994935
25	glycerophospholipid catabolic process (GO:0046475)	3.13903319
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.12387187
27	maturation of SSU-rRNA (GO:0030490)	3.11033744
28	primitive streak formation (GO:0090009)	3.11002063
29	cell proliferation in forebrain (GO:0021846)	3.09785702
30	cysteine metabolic process (GO:0006534)	3.08305738
31	inner ear receptor cell development (GO:0060119)	3.07648899
32	neuron fate determination (GO:0048664)	3.06053119
33	regulation of action potential (GO:0098900)	3.03577756
34	protein complex biogenesis (GO:0070271)	3.02563149
35	negative regulation of catecholamine secretion (GO:0033604)	3.02457087
36	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	3.00664470
37	axonal fasciculation (GO:0007413)	3.00145408
38	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.96400660
39	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.95655730
40	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.91413123
41	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.91413123
42	NADH dehydrogenase complex assembly (GO:0010257)	2.91413123
43	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.90716580
44	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.90716580
45	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	2.89751702
46	nucleobase catabolic process (GO:0046113)	2.87316571
47	positive regulation of gastrulation (GO:2000543)	2.85863449
48	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.85200708
49	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.83432994
50	mitochondrion transport along microtubule (GO:0047497)	2.83432994
51	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.83258833
52	brown fat cell differentiation (GO:0050873)	2.81789490
53	mechanosensory behavior (GO:0007638)	2.80459668
54	axonemal dynein complex assembly (GO:0070286)	2.80404325
55	cotranslational protein targeting to membrane (GO:0006613)	2.80183040
56	DNA damage response, detection of DNA damage (GO:0042769)	2.79057984
57	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.78077496
58	protein targeting to ER (GO:0045047)	2.75288930
59	DNA methylation involved in gamete generation (GO:0043046)	2.74798780
60	auditory behavior (GO:0031223)	2.74639213
61	lateral sprouting from an epithelium (GO:0060601)	2.74613932
62	protein localization to cilium (GO:0061512)	2.74025158
63	regulation of respiratory system process (GO:0044065)	2.73237143
64	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.72976908
65	substrate-independent telencephalic tangential migration (GO:0021826)	2.72976908
66	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.72308975
67	primary amino compound metabolic process (GO:1901160)	2.72032350
68	forebrain morphogenesis (GO:0048853)	2.71535365
69	gamma-aminobutyric acid transport (GO:0015812)	2.70512948
70	cochlea development (GO:0090102)	2.69282295
71	inner mitochondrial membrane organization (GO:0007007)	2.69149185
72	negative regulation of DNA biosynthetic process (GO:2000279)	2.67991486
73	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.67443152
74	response to parathyroid hormone (GO:0071107)	2.67316098
75	proton transport (GO:0015992)	2.65162826
76	cerebral cortex radially oriented cell migration (GO:0021799)	2.63748071
77	negative regulation of dendrite development (GO:2000171)	2.63385233
78	negative regulation of axon guidance (GO:1902668)	2.62045802
79	forebrain neuron development (GO:0021884)	2.61860467
80	cellular protein complex disassembly (GO:0043624)	2.61153436
81	positive regulation of RNA splicing (GO:0033120)	2.60613120
82	retinal ganglion cell axon guidance (GO:0031290)	2.60579186
83	hydrogen transport (GO:0006818)	2.59143456
84	behavioral response to ethanol (GO:0048149)	2.58457943
85	presynaptic membrane organization (GO:0097090)	2.58440622
86	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.58408499
87	viral protein processing (GO:0019082)	2.58182499
88	phosphorelay signal transduction system (GO:0000160)	2.56968154
89	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.56172452
90	regulation of gonadotropin secretion (GO:0032276)	2.55932463
91	viral life cycle (GO:0019058)	2.55635566
92	nonmotile primary cilium assembly (GO:0035058)	2.55379468
93	mitochondrial respiratory chain complex assembly (GO:0033108)	2.55319940
94	protein localization to endoplasmic reticulum (GO:0070972)	2.54648289
95	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.53931868
96	ATP synthesis coupled proton transport (GO:0015986)	2.53931868
97	response to nicotine (GO:0035094)	2.53753907
98	dendritic spine morphogenesis (GO:0060997)	2.52947526
99	positive regulation of DNA-templated transcription, initiation (GO:2000144)	2.51349723
100	translational elongation (GO:0006414)	2.51126738

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.19095787
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.92213778
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.15662292
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.03588652
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.96080951
6	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.91410231
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.82383788
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.53370761
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.42684848
10	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.37109669
11	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.27259622
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.20202211
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.17145832
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11736782
15	VDR_22108803_ChIP-Seq_LS180_Human	2.08458315
16	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.03271022
17	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.94340161
18	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.93864859
19	GBX2_23144817_ChIP-Seq_PC3_Human	1.90141342
20	FUS_26573619_Chip-Seq_HEK293_Human	1.89373209
21	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.87658168
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.85311531
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.79880966
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73433648
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.72785781
26	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.68440439
27	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.65068891
28	RNF2_27304074_Chip-Seq_NSC_Mouse	1.63721655
29	P300_19829295_ChIP-Seq_ESCs_Human	1.62731338
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.60644527
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.60098210
32	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.59853748
33	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.59853748
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.59122908
35	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.57228696
36	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.54926123
37	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.53754537
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52619648
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.52619648
40	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.52513274
41	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.49472981
42	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.47728842
43	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.47549345
44	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.47212720
45	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.43258553
46	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.42682082
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.40327549
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38977158
49	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.37454784
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37356545
51	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32020315
52	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.31825153
53	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.29610562
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27823078
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26594441
56	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.24862736
57	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.24531857
58	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.23842454
59	EWS_26573619_Chip-Seq_HEK293_Human	1.22228654
60	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.19388970
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.16881581
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15985482
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.13891278
64	TAF15_26573619_Chip-Seq_HEK293_Human	1.12721770
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10720530
66	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.09728057
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08648613
68	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08601303
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.06965553
70	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.06510452
71	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.05727222
72	BCAT_22108803_ChIP-Seq_LS180_Human	1.05366880
73	AR_25329375_ChIP-Seq_VCAP_Human	1.03861345
74	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.03858483
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01042452
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00715321
77	ER_23166858_ChIP-Seq_MCF-7_Human	1.00262936
78	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.99407437
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98384984
80	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96294567
81	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.94997157
82	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.94613543
83	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.93850293
84	STAT3_23295773_ChIP-Seq_U87_Human	0.93620074
85	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93222718
86	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93222718
87	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.92354759
88	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91790539
89	RUNX2_22187159_ChIP-Seq_PCA_Human	0.91300111
90	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.90638107
91	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.90315499
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.88426311
93	P53_22387025_ChIP-Seq_ESCs_Mouse	0.88039815
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.87273891
95	IGF1R_20145208_ChIP-Seq_DFB_Human	0.87192417
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.86717251
97	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.86208708
98	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85575874
99	NCOR_22424771_ChIP-Seq_293T_Human	0.84802629
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.84540941

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	4.63471329
2	MP0004145_abnormal_muscle_electrophysio	4.10891645
3	MP0003880_abnormal_central_pattern	3.15070066
4	MP0009379_abnormal_foot_pigmentation	2.99701623
5	MP0002102_abnormal_ear_morphology	2.99076218
6	MP0002736_abnormal_nociception_after	2.75607567
7	MP0005423_abnormal_somatic_nervous	2.33643936
8	MP0006276_abnormal_autonomic_nervous	2.32387448
9	MP0003183_abnormal_peptide_metabolism	2.32012232
10	MP0003122_maternal_imprinting	2.19818700
11	MP0004142_abnormal_muscle_tone	2.18335061
12	MP0001188_hyperpigmentation	2.10452035
13	MP0000778_abnormal_nervous_system	2.08413015
14	MP0000631_abnormal_neuroendocrine_gland	2.05701852
15	MP0006292_abnormal_olfactory_placode	2.05294099
16	MP0002184_abnormal_innervation	2.02449948
17	MP0002735_abnormal_chemical_nociception	2.02312943
18	MP0008872_abnormal_physiological_respon	2.01457975
19	MP0001529_abnormal_vocalization	1.98320693
20	MP0009046_muscle_twitch	1.95348363
21	MP0001968_abnormal_touch/_nociception	1.92709495
22	MP0004147_increased_porphyrin_level	1.89541148
23	MP0009745_abnormal_behavioral_response	1.83955400
24	MP0002938_white_spotting	1.75491242
25	MP0001440_abnormal_grooming_behavior	1.72847052
26	MP0002063_abnormal_learning/memory/cond	1.71905930
27	MP0005645_abnormal_hypothalamus_physiol	1.71716867
28	MP0002822_catalepsy	1.69518035
29	MP0002272_abnormal_nervous_system	1.67892583
30	MP0002064_seizures	1.67216675
31	MP0005646_abnormal_pituitary_gland	1.65122310
32	MP0004885_abnormal_endolymph	1.60708622
33	MP0002653_abnormal_ependyma_morphology	1.58822503
34	MP0002572_abnormal_emotion/affect_behav	1.56536947
35	MP0000955_abnormal_spinal_cord	1.55872836
36	MP0003890_abnormal_embryonic-extraembry	1.51796732
37	MP0001905_abnormal_dopamine_level	1.50352293
38	MP0005551_abnormal_eye_electrophysiolog	1.48037223
39	MP0003635_abnormal_synaptic_transmissio	1.45393198
40	MP0001486_abnormal_startle_reflex	1.42161426
41	MP0003121_genomic_imprinting	1.39970970
42	MP0002909_abnormal_adrenal_gland	1.32703986
43	MP0002557_abnormal_social/conspecific_i	1.32406298
44	MP0002234_abnormal_pharynx_morphology	1.31433402
45	MP0002733_abnormal_thermal_nociception	1.30594765
46	MP0008995_early_reproductive_senescence	1.29160558
47	MP0002249_abnormal_larynx_morphology	1.26670774
48	MP0000026_abnormal_inner_ear	1.26218074
49	MP0003938_abnormal_ear_development	1.26022592
50	MP0002752_abnormal_somatic_nervous	1.25912691
51	MP0004270_analgesia	1.25693850
52	MP0005257_abnormal_intraocular_pressure	1.24270327
53	MP0002067_abnormal_sensory_capabilities	1.19441417
54	MP0002734_abnormal_mechanical_nocicepti	1.18805089
55	MP0002095_abnormal_skin_pigmentation	1.18757400
56	MP0004133_heterotaxia	1.17255656
57	MP0002882_abnormal_neuron_morphology	1.14318334
58	MP0000569_abnormal_digit_pigmentation	1.13477317
59	MP0000049_abnormal_middle_ear	1.13389302
60	MP0002751_abnormal_autonomic_nervous	1.13279176
61	MP0001970_abnormal_pain_threshold	1.12263503
62	MP0004924_abnormal_behavior	1.09655559
63	MP0005386_behavior/neurological_phenoty	1.09655559
64	MP0005084_abnormal_gallbladder_morpholo	1.07235727
65	MP0002638_abnormal_pupillary_reflex	1.04706086
66	MP0008875_abnormal_xenobiotic_pharmacok	1.03524086
67	MP0004811_abnormal_neuron_physiology	1.03056209
68	MP0002282_abnormal_trachea_morphology	1.02597565
69	MP0005360_urolithiasis	1.01287531
70	MP0005670_abnormal_white_adipose	0.99357863
71	MP0001986_abnormal_taste_sensitivity	0.98778231
72	MP0003119_abnormal_digestive_system	0.96429661
73	MP0002837_dystrophic_cardiac_calcinosis	0.95525756
74	MP0001984_abnormal_olfaction	0.92732654
75	MP0003186_abnormal_redox_activity	0.91688070
76	MP0001963_abnormal_hearing_physiology	0.89860690
77	MP0005448_abnormal_energy_balance	0.89841305
78	MP0001324_abnormal_eye_pigmentation	0.89417014
79	MP0005253_abnormal_eye_physiology	0.88466778
80	MP0002152_abnormal_brain_morphology	0.85752329
81	MP0002069_abnormal_eating/drinking_beha	0.84712387
82	MP0008877_abnormal_DNA_methylation	0.83779582
83	MP0005195_abnormal_posterior_eye	0.83704780
84	MP0003755_abnormal_palate_morphology	0.82416261
85	MP0003011_delayed_dark_adaptation	0.81716048
86	MP0001502_abnormal_circadian_rhythm	0.80493330
87	MP0002876_abnormal_thyroid_physiology	0.79403635
88	MP0003937_abnormal_limbs/digits/tail_de	0.78842568
89	MP0004859_abnormal_synaptic_plasticity	0.78295631
90	MP0003787_abnormal_imprinting	0.76714467
91	MP0008789_abnormal_olfactory_epithelium	0.76343259
92	MP0002160_abnormal_reproductive_system	0.75658784
93	MP0004134_abnormal_chest_morphology	0.75327622
94	MP0002066_abnormal_motor_capabilities/c	0.75281081
95	MP0001485_abnormal_pinna_reflex	0.73103321
96	MP0001944_abnormal_pancreas_morphology	0.72847559
97	MP0000537_abnormal_urethra_morphology	0.72324312
98	MP0003861_abnormal_nervous_system	0.71004413
99	MP0005499_abnormal_olfactory_system	0.70724546
100	MP0005394_taste/olfaction_phenotype	0.70724546

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Oligodactyly (hands) (HP:0001180)	4.68341066
2	Type II lissencephaly (HP:0007260)	4.36656698
3	Abnormality of the labia minora (HP:0012880)	4.11668444
4	Retinal dysplasia (HP:0007973)	3.93604476
5	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.28081233
6	Abnormality of alanine metabolism (HP:0010916)	3.28081233
7	Hyperalaninemia (HP:0003348)	3.28081233
8	Constricted visual fields (HP:0001133)	3.18164263
9	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.11962783
10	Focal motor seizures (HP:0011153)	3.10268825
11	True hermaphroditism (HP:0010459)	3.06286396
12	Oligodactyly (HP:0012165)	2.95029011
13	Limb dystonia (HP:0002451)	2.94889248
14	Stenosis of the external auditory canal (HP:0000402)	2.93201561
15	Medial flaring of the eyebrow (HP:0010747)	2.92695211
16	Polyphagia (HP:0002591)	2.92403968
17	Septo-optic dysplasia (HP:0100842)	2.91869596
18	Hip dysplasia (HP:0001385)	2.91275338
19	Labial hypoplasia (HP:0000066)	2.84461765
20	Gait imbalance (HP:0002141)	2.81557591
21	Pancreatic cysts (HP:0001737)	2.78728986
22	Lissencephaly (HP:0001339)	2.78108074
23	Intestinal atresia (HP:0011100)	2.72782751
24	Genital tract atresia (HP:0001827)	2.70133235
25	Pancreatic fibrosis (HP:0100732)	2.69975237
26	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.64692812
27	Nephrogenic diabetes insipidus (HP:0009806)	2.63439852
28	Split foot (HP:0001839)	2.62556247
29	Increased hepatocellular lipid droplets (HP:0006565)	2.53993401
30	Congenital primary aphakia (HP:0007707)	2.51630925
31	Hypoplastic female external genitalia (HP:0012815)	2.50198244
32	Abnormal respiratory motile cilium morphology (HP:0005938)	2.50063186
33	Abnormal respiratory epithelium morphology (HP:0012253)	2.50063186
34	Abnormal hair whorl (HP:0010721)	2.48764343
35	Thyroid-stimulating hormone excess (HP:0002925)	2.48167480
36	Short tibia (HP:0005736)	2.46626507
37	Vaginal atresia (HP:0000148)	2.45954034
38	Pendular nystagmus (HP:0012043)	2.45371921
39	Oligomenorrhea (HP:0000876)	2.43123555
40	3-Methylglutaconic aciduria (HP:0003535)	2.42562473
41	Delayed CNS myelination (HP:0002188)	2.41990709
42	Anencephaly (HP:0002323)	2.39226803
43	Congenital stationary night blindness (HP:0007642)	2.39211228
44	Broad-based gait (HP:0002136)	2.38853407
45	Maternal diabetes (HP:0009800)	2.37048991
46	Increased corneal curvature (HP:0100692)	2.36210121
47	Keratoconus (HP:0000563)	2.36210121
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.35973013
49	Conjugated hyperbilirubinemia (HP:0002908)	2.34410769
50	Gastrointestinal atresia (HP:0002589)	2.28488315
51	Lipid accumulation in hepatocytes (HP:0006561)	2.25993743
52	Abnormal ciliary motility (HP:0012262)	2.25071901
53	Myokymia (HP:0002411)	2.23853500
54	Inability to walk (HP:0002540)	2.23256275
55	Hypoplastic labia majora (HP:0000059)	2.13960654
56	Mitochondrial inheritance (HP:0001427)	2.10403519
57	Congenital, generalized hypertrichosis (HP:0004540)	2.08773135
58	Clumsiness (HP:0002312)	2.08608285
59	Attenuation of retinal blood vessels (HP:0007843)	2.07680795
60	Morphological abnormality of the pyramidal tract (HP:0002062)	2.06260707
61	Congenital sensorineural hearing impairment (HP:0008527)	2.05953768
62	Growth hormone deficiency (HP:0000824)	2.05900839
63	Cystic liver disease (HP:0006706)	2.05583347
64	Poor speech (HP:0002465)	2.02027346
65	Atonic seizures (HP:0010819)	2.01738050
66	Pachygyria (HP:0001302)	2.01239510
67	Epidermoid cyst (HP:0200040)	2.01130355
68	Macrocytic anemia (HP:0001972)	2.00542122
69	Male pseudohermaphroditism (HP:0000037)	1.96429315
70	Focal seizures (HP:0007359)	1.95141957
71	Optic nerve hypoplasia (HP:0000609)	1.94465441
72	Abnormal respiratory motile cilium physiology (HP:0012261)	1.94444640
73	Sleep apnea (HP:0010535)	1.94075113
74	Abnormality of the labia (HP:0000058)	1.93889336
75	Athetosis (HP:0002305)	1.93222780
76	Long nose (HP:0003189)	1.93062112
77	Reticulocytopenia (HP:0001896)	1.92421443
78	Abnormality of the labia majora (HP:0012881)	1.91709392
79	Abnormality of cells of the erythroid lineage (HP:0012130)	1.90834748
80	Agitation (HP:0000713)	1.90592820
81	Absent septum pellucidum (HP:0001331)	1.90562593
82	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.89086366
83	Absent/shortened dynein arms (HP:0200106)	1.88568467
84	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.88568467
85	Abnormal number of incisors (HP:0011064)	1.86330736
86	Heterochromia iridis (HP:0001100)	1.84930663
87	Spastic tetraplegia (HP:0002510)	1.84704386
88	Specific learning disability (HP:0001328)	1.82318184
89	Poor suck (HP:0002033)	1.80735323
90	Choroideremia (HP:0001139)	1.77517932
91	Deep palmar crease (HP:0006191)	1.75306467
92	Ulnar claw (HP:0001178)	1.75242080
93	Acute encephalopathy (HP:0006846)	1.74693109
94	Increased CSF lactate (HP:0002490)	1.74338731
95	Abnormality of midbrain morphology (HP:0002418)	1.73789962
96	Molar tooth sign on MRI (HP:0002419)	1.73789962
97	Nephronophthisis (HP:0000090)	1.73483630
98	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.72744540
99	Generalized myoclonic seizures (HP:0002123)	1.72523847
100	Acute necrotizing encephalopathy (HP:0006965)	1.71985956

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.92977046
2	MAP4K2	2.84123132
3	NTRK2	2.78557645
4	DYRK2	2.73813799
5	MINK1	2.61495329
6	SGK494	2.46379808
7	SGK223	2.46379808
8	PINK1	2.16474518
9	UHMK1	2.06864009
10	CASK	1.95546900
11	ADRBK2	1.91006926
12	MAPKAPK5	1.87006064
13	MAPK13	1.86408729
14	AKT3	1.81732249
15	MAP3K4	1.81629022
16	PNCK	1.68550018
17	EPHB2	1.67843997
18	NME1	1.59646324
19	SGK2	1.56814566
20	MAP2K4	1.56478771
21	TNIK	1.55470851
22	WNK3	1.52619136
23	NTRK3	1.50414811
24	EIF2AK1	1.47551051
25	DAPK2	1.47122084
26	MAP3K12	1.45517262
27	MAP2K7	1.37601230
28	DAPK3	1.36189229
29	PHKG2	1.35305597
30	PHKG1	1.35305597
31	OXSR1	1.33504949
32	PRKCG	1.28344679
33	WNK1	1.26467693
34	ADRBK1	1.22527725
35	BCKDK	1.21030923
36	WNK4	1.20016520
37	GRK1	1.18185601
38	GRK7	1.16563103
39	PKN1	1.16065990
40	PAK3	1.15162465
41	FGFR2	1.12170411
42	CDK19	1.10610576
43	MET	1.09274099
44	DYRK1B	1.05218770
45	DYRK3	1.01484509
46	BCR	1.01031257
47	MAP3K11	1.00763928
48	TAOK1	0.96569351
49	CSNK1G2	0.91062401
50	TYRO3	0.87540305
51	CSNK1G1	0.86551390
52	SGK3	0.83655694
53	SGK1	0.81606509
54	CAMK2B	0.79848978
55	ZAK	0.79089449
56	CAMK2D	0.75608380
57	CAMK2A	0.74779456
58	CSNK1A1	0.73904802
59	INSRR	0.73091682
60	PRKG1	0.72047813
61	CSNK1G3	0.71767692
62	PRKACA	0.69387838
63	MAPK15	0.66122910
64	BRD4	0.62280930
65	STK39	0.62125350
66	CSF1R	0.60474424
67	MAP3K5	0.60276280
68	PRKCE	0.60217193
69	DYRK1A	0.60009500
70	FRK	0.59550427
71	CDK5	0.58480226
72	CSNK1A1L	0.57953075
73	MAP3K6	0.57848372
74	PRKCZ	0.57257059
75	ROCK1	0.56336006
76	PRKCD	0.55160830
77	PRKCQ	0.53946670
78	AURKA	0.52749792
79	NUAK1	0.52399243
80	CAMK2G	0.51933353
81	EGFR	0.49361516
82	TRIM28	0.49155993
83	PASK	0.48509647
84	RPS6KA6	0.46428898
85	PRKCH	0.46219268
86	RPS6KA1	0.46035966
87	PTK2B	0.43109307
88	RPS6KB1	0.41979155
89	FYN	0.41210477
90	RPS6KA5	0.40693758
91	MAP3K3	0.40642021
92	PRKACB	0.39251207
93	LIMK1	0.38693852
94	CSNK1E	0.38611823
95	CAMK1	0.37141878
96	OBSCN	0.35853421
97	EIF2AK3	0.35284596
98	RPS6KA3	0.34544354
99	PRKACG	0.32896259
100	RPS6KA2	0.32302883

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.54411083
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.41292626
3	Ribosome_Homo sapiens_hsa03010	3.24393675
4	Nicotine addiction_Homo sapiens_hsa05033	3.13838094
5	Parkinsons disease_Homo sapiens_hsa05012	2.91358769
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.85949459
7	Protein export_Homo sapiens_hsa03060	2.67897140
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.50475567
9	Basal transcription factors_Homo sapiens_hsa03022	2.31583599
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.27572769
11	Phototransduction_Homo sapiens_hsa04744	2.14651091
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.12614756
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.02883951
14	Alzheimers disease_Homo sapiens_hsa05010	2.00168441
15	Morphine addiction_Homo sapiens_hsa05032	1.96444128
16	Collecting duct acid secretion_Homo sapiens_hsa04966	1.95964100
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.94368606
18	Huntingtons disease_Homo sapiens_hsa05016	1.93718990
19	GABAergic synapse_Homo sapiens_hsa04727	1.87700571
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.85349907
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73165268
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.67795698
23	Circadian entrainment_Homo sapiens_hsa04713	1.60097707
24	Olfactory transduction_Homo sapiens_hsa04740	1.54353124
25	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.52881298
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.49797977
27	Sulfur metabolism_Homo sapiens_hsa00920	1.44949618
28	Dopaminergic synapse_Homo sapiens_hsa04728	1.37085623
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.35729494
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.32310759
31	Regulation of autophagy_Homo sapiens_hsa04140	1.31385913
32	Serotonergic synapse_Homo sapiens_hsa04726	1.31371980
33	Butanoate metabolism_Homo sapiens_hsa00650	1.30432969
34	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.16382966
35	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.15345137
36	Taste transduction_Homo sapiens_hsa04742	1.14570094
37	Insulin secretion_Homo sapiens_hsa04911	1.13910232
38	Basal cell carcinoma_Homo sapiens_hsa05217	1.07850264
39	Proteasome_Homo sapiens_hsa03050	1.06957969
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.06536440
41	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.05978959
42	One carbon pool by folate_Homo sapiens_hsa00670	0.96778621
43	Nitrogen metabolism_Homo sapiens_hsa00910	0.94514559
44	Ether lipid metabolism_Homo sapiens_hsa00565	0.93546916
45	Cocaine addiction_Homo sapiens_hsa05030	0.93314235
46	Cholinergic synapse_Homo sapiens_hsa04725	0.91354103
47	Axon guidance_Homo sapiens_hsa04360	0.89498827
48	Long-term depression_Homo sapiens_hsa04730	0.89291925
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.89186446
50	Amphetamine addiction_Homo sapiens_hsa05031	0.85627752
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85025129
52	Spliceosome_Homo sapiens_hsa03040	0.84740276
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84563427
54	RNA degradation_Homo sapiens_hsa03018	0.83878453
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.78599023
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76651125
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75895774
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72610201
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72003809
60	Alcoholism_Homo sapiens_hsa05034	0.71148706
61	Salivary secretion_Homo sapiens_hsa04970	0.68589200
62	Retinol metabolism_Homo sapiens_hsa00830	0.66337703
63	Propanoate metabolism_Homo sapiens_hsa00640	0.65623569
64	Peroxisome_Homo sapiens_hsa04146	0.63165914
65	Vibrio cholerae infection_Homo sapiens_hsa05110	0.60855053
66	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60702254
67	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.58985684
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58056158
69	Caffeine metabolism_Homo sapiens_hsa00232	0.50948078
70	Circadian rhythm_Homo sapiens_hsa04710	0.48910536
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48468583
72	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.48248553
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46806973
74	Arginine biosynthesis_Homo sapiens_hsa00220	0.46800629
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.46632036
76	Ras signaling pathway_Homo sapiens_hsa04014	0.44784845
77	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.44272950
78	Melanogenesis_Homo sapiens_hsa04916	0.43160039
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.41684547
80	Renin secretion_Homo sapiens_hsa04924	0.41194323
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.40903838
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.39761556
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38547187
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37476352
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.37304607
86	Metabolic pathways_Homo sapiens_hsa01100	0.37114501
87	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.36120700
88	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.35851446
89	Type II diabetes mellitus_Homo sapiens_hsa04930	0.33677961
90	Gap junction_Homo sapiens_hsa04540	0.30709733
91	Fanconi anemia pathway_Homo sapiens_hsa03460	0.29494124
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27671870
93	Gastric acid secretion_Homo sapiens_hsa04971	0.27631861
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.26811868
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.26007988
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25063624
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.24675607
98	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.24079517
99	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.23954198
100	Steroid biosynthesis_Homo sapiens_hsa00100	0.23762409

RTN3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »