RTN4IP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, mental retardation, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine catabolic process (GO:0006554)6.44351733
2lysine metabolic process (GO:0006553)6.44351733
3fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.68973677
4tricarboxylic acid cycle (GO:0006099)5.66442229
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.64618427
6L-phenylalanine catabolic process (GO:0006559)5.64618427
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.58333518
8L-phenylalanine metabolic process (GO:0006558)5.58333518
9alpha-linolenic acid metabolic process (GO:0036109)5.49628362
102-oxoglutarate metabolic process (GO:0006103)5.33889698
11glyoxylate metabolic process (GO:0046487)5.18807447
12aspartate family amino acid catabolic process (GO:0009068)5.13965411
13proteasome assembly (GO:0043248)5.03520892
14aromatic amino acid family catabolic process (GO:0009074)4.98186514
15NADH metabolic process (GO:0006734)4.82401577
16fatty acid beta-oxidation (GO:0006635)4.81327084
17CENP-A containing nucleosome assembly (GO:0034080)4.78408511
18kynurenine metabolic process (GO:0070189)4.76492263
19chromatin remodeling at centromere (GO:0031055)4.72049008
20oxaloacetate metabolic process (GO:0006107)4.62761959
21mitotic metaphase plate congression (GO:0007080)4.60313846
22acetyl-CoA metabolic process (GO:0006084)4.55415820
23carnitine shuttle (GO:0006853)4.51090854
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.44277600
25indole-containing compound catabolic process (GO:0042436)4.42688264
26indolalkylamine catabolic process (GO:0046218)4.42688264
27tryptophan catabolic process (GO:0006569)4.42688264
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.40989203
29fatty acid transmembrane transport (GO:1902001)4.38497793
30fatty acid catabolic process (GO:0009062)4.38207955
31protein localization to kinetochore (GO:0034501)4.36999984
32cellular ketone body metabolic process (GO:0046950)4.35993111
33fatty acid oxidation (GO:0019395)4.35005517
34tryptophan metabolic process (GO:0006568)4.31778311
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.29382307
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.26373691
37lipid oxidation (GO:0034440)4.24884368
38amino-acid betaine metabolic process (GO:0006577)4.24646381
39regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.20312976
40establishment of integrated proviral latency (GO:0075713)4.16660798
41branched-chain amino acid catabolic process (GO:0009083)4.15423924
42ribosome assembly (GO:0042255)4.11372217
43triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.10467265
44bile acid biosynthetic process (GO:0006699)4.10150522
45DNA strand elongation involved in DNA replication (GO:0006271)4.08633565
46monocarboxylic acid catabolic process (GO:0072329)4.08114288
47short-chain fatty acid metabolic process (GO:0046459)4.06166428
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.05934570
49histone exchange (GO:0043486)4.04548218
50negative regulation of ligase activity (GO:0051352)4.03639020
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.03639020
52alpha-amino acid catabolic process (GO:1901606)3.98589740
53sulfur amino acid catabolic process (GO:0000098)3.98433615
54DNA strand elongation (GO:0022616)3.97105931
55telomere maintenance via semi-conservative replication (GO:0032201)3.93136662
56branched-chain amino acid metabolic process (GO:0009081)3.88363409
57protein localization to chromosome, centromeric region (GO:0071459)3.87633510
58regulation of acyl-CoA biosynthetic process (GO:0050812)3.87480286
59cysteine metabolic process (GO:0006534)3.87465341
60serine family amino acid catabolic process (GO:0009071)3.86536119
61acylglycerol homeostasis (GO:0055090)3.85142555
62triglyceride homeostasis (GO:0070328)3.85142555
63DNA replication checkpoint (GO:0000076)3.82501276
64negative regulation of fatty acid biosynthetic process (GO:0045717)3.82179162
65succinate metabolic process (GO:0006105)3.80665416
66DNA replication-independent nucleosome assembly (GO:0006336)3.80461524
67DNA replication-independent nucleosome organization (GO:0034724)3.80461524
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.78255311
69regulation of sequestering of triglyceride (GO:0010889)3.78203705
70regulation of triglyceride catabolic process (GO:0010896)3.77231217
71sarcomere organization (GO:0045214)3.76634966
72cellular amino acid catabolic process (GO:0009063)3.75143256
73chaperone-mediated protein transport (GO:0072321)3.74454398
74dicarboxylic acid biosynthetic process (GO:0043650)3.74449714
75oxidative phosphorylation (GO:0006119)3.73811836
76metaphase plate congression (GO:0051310)3.73407398
77ATP synthesis coupled proton transport (GO:0015986)3.72793823
78energy coupled proton transport, down electrochemical gradient (GO:0015985)3.72793823
79ketone body metabolic process (GO:1902224)3.72396514
80IMP biosynthetic process (GO:0006188)3.69200414
81peptidyl-glutamic acid carboxylation (GO:0017187)3.69160008
82protein carboxylation (GO:0018214)3.69160008
83aromatic amino acid family metabolic process (GO:0009072)3.68371828
84organic acid catabolic process (GO:0016054)3.67953037
85carboxylic acid catabolic process (GO:0046395)3.67953037
86valine metabolic process (GO:0006573)3.67583854
87coenzyme catabolic process (GO:0009109)3.67327430
88urea cycle (GO:0000050)3.67305537
89urea metabolic process (GO:0019627)3.67305537
90carnitine metabolic process (GO:0009437)3.65904379
91termination of RNA polymerase III transcription (GO:0006386)3.65159300
92transcription elongation from RNA polymerase III promoter (GO:0006385)3.65159300
93tricarboxylic acid metabolic process (GO:0072350)3.64642623
94regulation of mitotic spindle checkpoint (GO:1903504)3.63247182
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.63247182
96ethanol oxidation (GO:0006069)3.62963140
97mitotic sister chromatid segregation (GO:0000070)3.62766822
98regulation of mitochondrial translation (GO:0070129)3.61937739
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.55813641
100regulation of coenzyme metabolic process (GO:0051196)3.54931629
101regulation of cofactor metabolic process (GO:0051193)3.54931629
102formation of translation preinitiation complex (GO:0001731)3.52770843
103high-density lipoprotein particle remodeling (GO:0034375)3.50617645
104telomere maintenance via recombination (GO:0000722)3.50464970
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.48811354
106regulation of cellular amino acid metabolic process (GO:0006521)3.48249585
107purine nucleobase biosynthetic process (GO:0009113)3.48164555
108DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.47945082
109signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47142960
110signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47142960
111signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47142960
112amino-acid betaine transport (GO:0015838)3.46488361
113carnitine transport (GO:0015879)3.46488361
114negative regulation of fibrinolysis (GO:0051918)3.46312609
115homocysteine metabolic process (GO:0050667)3.46302189
116intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.46028753
117signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.46028753
118glycine metabolic process (GO:0006544)3.45818641
119bile acid metabolic process (GO:0008206)3.45611045
120serine family amino acid metabolic process (GO:0009069)3.44345642
121carnitine transmembrane transport (GO:1902603)3.44315236
122signal transduction involved in DNA integrity checkpoint (GO:0072401)3.41885958
123signal transduction involved in DNA damage checkpoint (GO:0072422)3.41885958
124mitotic recombination (GO:0006312)3.41783931
125DNA replication-dependent nucleosome assembly (GO:0006335)3.41157430
126DNA replication-dependent nucleosome organization (GO:0034723)3.41157430
127serine family amino acid biosynthetic process (GO:0009070)3.41155880
128regulation of helicase activity (GO:0051095)3.37815235
129spindle checkpoint (GO:0031577)3.37788343
130positive regulation of ligase activity (GO:0051351)3.37562700
131nitrogen cycle metabolic process (GO:0071941)3.36882799
132signal transduction involved in cell cycle checkpoint (GO:0072395)3.36060441
133tyrosine metabolic process (GO:0006570)3.34854281
134nucleotide-excision repair, DNA gap filling (GO:0006297)3.33326903
135regulation of ubiquitin-protein transferase activity (GO:0051438)3.33292643
136sister chromatid segregation (GO:0000819)3.33223316
137biotin metabolic process (GO:0006768)3.32549439
138mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32443257
139nucleobase biosynthetic process (GO:0046112)3.32283898
140linoleic acid metabolic process (GO:0043651)3.32181272
141NAD metabolic process (GO:0019674)3.32082956
142regulation of fatty acid oxidation (GO:0046320)3.31954010
143glutamate metabolic process (GO:0006536)3.30604730
144cardiac myofibril assembly (GO:0055003)3.28599523
145mitotic chromosome condensation (GO:0007076)3.28058678
146cellular modified amino acid catabolic process (GO:0042219)3.27937377
147positive regulation of fatty acid beta-oxidation (GO:0032000)3.27899748
148thioester metabolic process (GO:0035383)3.27790578
149acyl-CoA metabolic process (GO:0006637)3.27790578
150IMP metabolic process (GO:0046040)3.27465790
151ribosomal large subunit biogenesis (GO:0042273)3.27137687
152drug transmembrane transport (GO:0006855)3.26211993
153spliceosomal snRNP assembly (GO:0000387)3.25958130
154negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24700477
155negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24700477
156negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24700477
157negative regulation of mitotic sister chromatid separation (GO:2000816)3.24700477
158negative regulation of sister chromatid segregation (GO:0033046)3.24700477
159regulation of ligase activity (GO:0051340)3.24451204
160establishment of viral latency (GO:0019043)3.23842200
161mitotic spindle checkpoint (GO:0071174)3.23338123
162negative regulation of chromosome segregation (GO:0051985)3.22748168
163DNA double-strand break processing (GO:0000729)3.22711999
164regulation of fibrinolysis (GO:0051917)3.19305528
165dicarboxylic acid metabolic process (GO:0043648)3.19038594
166kinetochore organization (GO:0051383)3.18411948
167cullin deneddylation (GO:0010388)3.17969318
168indolalkylamine metabolic process (GO:0006586)3.17640660
169respiratory electron transport chain (GO:0022904)3.16375915
170quaternary ammonium group transport (GO:0015697)3.15227298
171regulation of protein activation cascade (GO:2000257)3.14718327
172establishment of chromosome localization (GO:0051303)3.14163109
173exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13405576
174acyl-CoA biosynthetic process (GO:0071616)3.12500118
175thioester biosynthetic process (GO:0035384)3.12500118
176regulation of spindle organization (GO:0090224)3.11966963
177negative regulation of fatty acid metabolic process (GO:0045922)3.11683230
178rRNA modification (GO:0000154)3.09631857
179regulation of relaxation of muscle (GO:1901077)3.09287329
180regulation of chromosome segregation (GO:0051983)3.09284703
181DNA catabolic process, exonucleolytic (GO:0000738)3.08967310
182protein deneddylation (GO:0000338)3.08632603
183positive regulation of fatty acid oxidation (GO:0046321)3.08405956
184cell cycle G1/S phase transition (GO:0044843)3.08340240
185G1/S transition of mitotic cell cycle (GO:0000082)3.08340240
186nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07102340
187positive regulation of chromosome segregation (GO:0051984)3.06593553
188complement activation, alternative pathway (GO:0006957)3.06401223
189electron transport chain (GO:0022900)3.06259454
190regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05662626
191regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05662626
192DNA ligation (GO:0006266)3.04866895
193replication fork processing (GO:0031297)3.03007608
194mitochondrial respiratory chain complex assembly (GO:0033108)3.02299473
195ribosome biogenesis (GO:0042254)3.02009815
196mitotic spindle assembly checkpoint (GO:0007094)3.01007814
197synapsis (GO:0007129)2.99978323
198spindle assembly checkpoint (GO:0071173)2.98831835
199pseudouridine synthesis (GO:0001522)2.98734450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.96658586
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.79210062
3E2F7_22180533_ChIP-Seq_HELA_Human6.52574902
4RXR_22158963_ChIP-Seq_LIVER_Mouse6.06215358
5PPARA_22158963_ChIP-Seq_LIVER_Mouse5.65934320
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.74193775
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.44133352
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.18850617
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.17746324
10MYC_18555785_ChIP-Seq_MESCs_Mouse4.07254842
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.98509798
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.69620377
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.60647967
14FOXM1_23109430_ChIP-Seq_U2OS_Human3.54997739
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.35581160
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.13200439
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.02504508
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.95792495
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87574944
20* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73563839
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.57217945
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55912041
23VDR_23849224_ChIP-Seq_CD4+_Human2.41222761
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35265130
25ELK1_19687146_ChIP-ChIP_HELA_Human2.34594102
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.25445251
27DCP1A_22483619_ChIP-Seq_HELA_Human2.22859647
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12334969
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08173755
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03359699
31AR_21909140_ChIP-Seq_LNCAP_Human1.99803177
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98609883
33XRN2_22483619_ChIP-Seq_HELA_Human1.97064487
34TTF2_22483619_ChIP-Seq_HELA_Human1.94155933
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87392186
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85628424
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84445896
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82116859
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.79948409
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79809374
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.79331965
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77630584
43* SRF_21415370_ChIP-Seq_HL-1_Mouse1.75853219
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73433618
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70537616
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61944638
47BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.61800525
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61039892
49* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54158644
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50485612
51CLOCK_20551151_ChIP-Seq_293T_Human1.48369985
52* MYC_18940864_ChIP-ChIP_HL60_Human1.47200228
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46749434
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45521467
55TBX20_22080862_ChIP-Seq_HEART_Mouse1.42236574
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.42236574
57GATA1_22025678_ChIP-Seq_K562_Human1.40379054
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39457277
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38397705
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.32594954
61ZNF263_19887448_ChIP-Seq_K562_Human1.28710284
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28104233
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27246097
64* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26952502
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23705792
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23638260
67GATA4_21415370_ChIP-Seq_HL-1_Mouse1.21542738
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21220627
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21122281
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19212331
71* HNF4A_19822575_ChIP-Seq_HepG2_Human1.17540239
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17347579
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16967632
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.16653977
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.14252018
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.13860258
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12357091
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12180457
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10405175
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06549085
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06058682
82* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04201816
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04029003
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.03544770
85* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03174558
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03013871
87TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02945513
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.99904589
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99713513
90OCT4_20526341_ChIP-Seq_ESCs_Human0.99415718
91* SOX17_20123909_ChIP-Seq_XEN_Mouse0.97383477
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.95544532
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.95437891
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93351049
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91396014
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91124874
97ETS1_20019798_ChIP-Seq_JURKAT_Human0.89878503
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88527459
99RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87400612
100RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85752040
101TFEB_21752829_ChIP-Seq_HELA_Human0.85699374
102FOXP3_21729870_ChIP-Seq_TREG_Human0.84736136
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83529063
104MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83508417
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83461739
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.83336366
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82774034
108POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80439887
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79012171
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78927715
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78810575
112EWS_26573619_Chip-Seq_HEK293_Human0.77463843
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77385067
114EST1_17652178_ChIP-ChIP_JURKAT_Human0.77114698
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.76251887
116* HTT_18923047_ChIP-ChIP_STHdh_Human0.75405552
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75316391
118* YY1_21170310_ChIP-Seq_MESCs_Mouse0.72224501
119* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72169725
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.71825561
121ELF5_23300383_ChIP-Seq_T47D_Human0.70791379
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70677769
123* BCL6_27268052_Chip-Seq_Bcells_Human0.70531853
124RARA_24833708_ChIP-Seq_LIVER_Mouse0.70390227
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.69713732
126GABP_17652178_ChIP-ChIP_JURKAT_Human0.69685137
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69238130
128CIITA_25753668_ChIP-Seq_RAJI_Human0.68806364
129SOX2_27498859_Chip-Seq_STOMACH_Mouse0.68512544
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.68505865
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.68476196
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68395037
133GABP_19822575_ChIP-Seq_HepG2_Human0.68055017
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.67925797
135* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.67041389
136FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.66994514
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.66976459
138MYCN_18555785_ChIP-Seq_MESCs_Mouse0.66930661
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.66292206
140KLF4_18555785_ChIP-Seq_MESCs_Mouse0.66236615
141* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.65057291
142CEBPB_22108803_ChIP-Seq_LS180_Human0.64727315
143* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.64622209
144HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.64427109
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64250643
146AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64100361
147CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.63869118
148* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.63593628
149KDM5A_27292631_Chip-Seq_BREAST_Human0.63225575
150THAP11_20581084_ChIP-Seq_MESCs_Mouse0.62942612
151ZFX_18555785_ChIP-Seq_MESCs_Mouse0.62804981
152TET1_21451524_ChIP-Seq_MESCs_Mouse0.62729284
153HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.62098928
154TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.62042709
155FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.62000084
156SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.61957313
157FOXH1_21741376_ChIP-Seq_ESCs_Human0.60243374
158* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.60227986
159FUS_26573619_Chip-Seq_HEK293_Human0.60133069
160SPI1_20517297_ChIP-Seq_HL60_Human0.58784504
161MYC_22102868_ChIP-Seq_BL_Human0.57549110
162PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.56654401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.63601964
2MP0005360_urolithiasis5.62122348
3MP0008058_abnormal_DNA_repair5.03601630
4MP0003693_abnormal_embryo_hatching5.03012487
5MP0005085_abnormal_gallbladder_physiolo4.90459679
6MP0002837_dystrophic_cardiac_calcinosis4.78699859
7MP0010094_abnormal_chromosome_stability4.62694842
8MP0005365_abnormal_bile_salt4.48294565
9MP0004957_abnormal_blastocyst_morpholog4.16575528
10MP0003806_abnormal_nucleotide_metabolis4.11073497
11MP0003111_abnormal_nucleus_morphology3.95962075
12MP0003718_maternal_effect3.84843585
13MP0008057_abnormal_DNA_replication3.75133736
14MP0003077_abnormal_cell_cycle3.69890662
15MP0003646_muscle_fatigue3.53509357
16MP0008875_abnormal_xenobiotic_pharmacok3.50461158
17MP0008877_abnormal_DNA_methylation3.38194545
18MP0004084_abnormal_cardiac_muscle3.11341339
19MP0008932_abnormal_embryonic_tissue3.10443990
20MP0003252_abnormal_bile_duct2.72136718
21MP0004215_abnormal_myocardial_fiber2.57119260
22MP0000751_myopathy2.54968399
23MP0005332_abnormal_amino_acid2.54807821
24MP0010329_abnormal_lipoprotein_level2.50114444
25MP0004036_abnormal_muscle_relaxation2.48875515
26MP0008007_abnormal_cellular_replicative2.48033832
27MP0003941_abnormal_skin_development2.41337452
28MP0005330_cardiomyopathy2.38469988
29MP0006036_abnormal_mitochondrial_physio2.36552060
30MP0009840_abnormal_foam_cell2.33862255
31MP0000749_muscle_degeneration2.31056139
32MP0002102_abnormal_ear_morphology2.26657434
33MP0003195_calcinosis2.25854730
34MP0006292_abnormal_olfactory_placode2.23178954
35MP0001730_embryonic_growth_arrest2.02546069
36MP0004130_abnormal_muscle_cell2.01418550
37MP0001666_abnormal_nutrient_absorption1.93422807
38MP0005083_abnormal_biliary_tract1.90410981
39MP0001293_anophthalmia1.89049004
40MP0002972_abnormal_cardiac_muscle1.84227719
41MP0003656_abnormal_erythrocyte_physiolo1.82842272
42MP0005451_abnormal_body_composition1.81592581
43MP0005319_abnormal_enzyme/_coenzyme1.79133577
44MP0000350_abnormal_cell_proliferation1.77959254
45MP0002269_muscular_atrophy1.77924886
46MP0003786_premature_aging1.71442890
47MP0002118_abnormal_lipid_homeostasis1.70283855
48MP0005670_abnormal_white_adipose1.66089335
49MP0003136_yellow_coat_color1.64504230
50MP0004087_abnormal_muscle_fiber1.62228825
51MP0000609_abnormal_liver_physiology1.61818665
52MP0003137_abnormal_impulse_conducting1.61394057
53MP0005584_abnormal_enzyme/coenzyme_acti1.59791246
54MP0010030_abnormal_orbit_morphology1.56923909
55MP0008789_abnormal_olfactory_epithelium1.55238409
56MP0003221_abnormal_cardiomyocyte_apopto1.54812233
57MP0000747_muscle_weakness1.54557965
58MP0006035_abnormal_mitochondrial_morpho1.53102167
59MP0009379_abnormal_foot_pigmentation1.51125097
60MP0005620_abnormal_muscle_contractility1.50667167
61MP0002210_abnormal_sex_determination1.48688449
62MP0005385_cardiovascular_system_phenoty1.47672418
63MP0001544_abnormal_cardiovascular_syste1.47672418
64MP0001697_abnormal_embryo_size1.46614833
65MP0008775_abnormal_heart_ventricle1.46538216
66MP0003567_abnormal_fetal_cardiomyocyte1.43834666
67MP0001929_abnormal_gametogenesis1.41948466
68MP0003890_abnormal_embryonic-extraembry1.40683947
69MP0010307_abnormal_tumor_latency1.39221935
70MP0005380_embryogenesis_phenotype1.37362557
71MP0001672_abnormal_embryogenesis/_devel1.37362557
72MP0006138_congestive_heart_failure1.36240471
73MP0010630_abnormal_cardiac_muscle1.35820542
74MP0009643_abnormal_urine_homeostasis1.34803445
75MP0001529_abnormal_vocalization1.33649090
76MP0002234_abnormal_pharynx_morphology1.33581372
77MP0001764_abnormal_homeostasis1.32919508
78MP0001986_abnormal_taste_sensitivity1.29265453
79MP0003186_abnormal_redox_activity1.26286686
80MP0005666_abnormal_adipose_tissue1.26110982
81MP0000313_abnormal_cell_death1.25916858
82MP0002080_prenatal_lethality1.23730264
83MP0004147_increased_porphyrin_level1.23538561
84MP0004085_abnormal_heartbeat1.21918621
85MP0005395_other_phenotype1.21438263
86MP0005266_abnormal_metabolism1.17798073
87MP0002084_abnormal_developmental_patter1.16080860
88MP0006072_abnormal_retinal_apoptosis1.15905024
89MP0000653_abnormal_sex_gland1.15188744
90MP0001145_abnormal_male_reproductive1.14176086
91MP0002085_abnormal_embryonic_tissue1.14158546
92MP0004043_abnormal_pH_regulation1.13959545
93MP0002877_abnormal_melanocyte_morpholog1.13932476
94MP0003984_embryonic_growth_retardation1.13162640
95MP0002106_abnormal_muscle_physiology1.12494172
96MP0003123_paternal_imprinting1.11124473
97MP0004484_altered_response_of1.11046833
98MP0004019_abnormal_vitamin_homeostasis1.10652291
99MP0002088_abnormal_embryonic_growth/wei1.09938052
100MP0003868_abnormal_feces_composition1.03807584
101MP0003191_abnormal_cellular_cholesterol1.03489727
102MP0002138_abnormal_hepatobiliary_system1.03173692
103MP0002078_abnormal_glucose_homeostasis1.01749403
104MP0009697_abnormal_copulation0.98304150
105MP0002127_abnormal_cardiovascular_syste0.97865392
106MP0002160_abnormal_reproductive_system0.97244006
107MP0003121_genomic_imprinting0.97017457
108MP0002938_white_spotting0.95249082
109MP0000750_abnormal_muscle_regeneration0.92373592
110MP0003950_abnormal_plasma_membrane0.92082572
111MP0005535_abnormal_body_temperature0.89992324
112MP0000598_abnormal_liver_morphology0.89663074
113MP0000759_abnormal_skeletal_muscle0.89575178
114MP0002971_abnormal_brown_adipose0.89536219
115MP0000372_irregular_coat_pigmentation0.89211845
116MP0005499_abnormal_olfactory_system0.88673420
117MP0005394_taste/olfaction_phenotype0.88673420
118MP0002019_abnormal_tumor_incidence0.87076903
119MP0003937_abnormal_limbs/digits/tail_de0.86519306
120MP0003699_abnormal_female_reproductive0.86507584
121MP0000490_abnormal_crypts_of0.86287746
122MP0000230_abnormal_systemic_arterial0.84898367
123MP0001119_abnormal_female_reproductive0.83927147
124MP0002090_abnormal_vision0.83516248
125MP0005369_muscle_phenotype0.82837825
126MP0003698_abnormal_male_reproductive0.82725640
127MP0005375_adipose_tissue_phenotype0.82326616
128MP0005636_abnormal_mineral_homeostasis0.82043089
129MP0005423_abnormal_somatic_nervous0.81975593
130MP0002332_abnormal_exercise_endurance0.81708993
131MP0004145_abnormal_muscle_electrophysio0.80377488
132MP0004233_abnormal_muscle_weight0.79986979
133MP0002161_abnormal_fertility/fecundity0.79191685
134MP0005376_homeostasis/metabolism_phenot0.77764340
135MP0001881_abnormal_mammary_gland0.77713664
136MP0002233_abnormal_nose_morphology0.76894567
137MP0001756_abnormal_urination0.76445143
138MP0001853_heart_inflammation0.76347103
139MP0002970_abnormal_white_adipose0.75811323
140MP0001286_abnormal_eye_development0.74276980
141MP0009642_abnormal_blood_homeostasis0.72951285
142MP0004197_abnormal_fetal_growth/weight/0.72638590
143MP0002697_abnormal_eye_size0.69840418
144MP0003315_abnormal_perineum_morphology0.69427825
145MP0002277_abnormal_respiratory_mucosa0.68130819
146MP0004185_abnormal_adipocyte_glucose0.67878376
147MP0000003_abnormal_adipose_tissue0.65976907
148MP0005334_abnormal_fat_pad0.65181417
149MP0003119_abnormal_digestive_system0.65165768
150MP0002086_abnormal_extraembryonic_tissu0.65019948
151MP0000049_abnormal_middle_ear0.64230509
152MP0002396_abnormal_hematopoietic_system0.62549264
153MP0002111_abnormal_tail_morphology0.59912155
154MP0005165_increased_susceptibility_to0.59376013
155MP0010352_gastrointestinal_tract_polyps0.59323700
156MP0008995_early_reproductive_senescence0.59239665
157MP0002177_abnormal_outer_ear0.57627927
158MP0009672_abnormal_birth_weight0.57488389
159MP0005501_abnormal_skin_physiology0.56344966
160MP0000343_altered_response_to0.56253729
161MP0000266_abnormal_heart_morphology0.56142286
162MP0008469_abnormal_protein_level0.55728177
163MP0005384_cellular_phenotype0.55523777
164MP0002876_abnormal_thyroid_physiology0.55475352
165MP0008874_decreased_physiological_sensi0.55409738
166MP0001188_hyperpigmentation0.54591046
167MP0001661_extended_life_span0.52562413
168MP0009763_increased_sensitivity_to0.51874463
169MP0002822_catalepsy0.50705986
170MP0004264_abnormal_extraembryonic_tissu0.48877884
171MP0003828_pulmonary_edema0.47014264
172MP0003953_abnormal_hormone_level0.46734938
173MP0000604_amyloidosis0.46196143
174MP0000013_abnormal_adipose_tissue0.45536101
175MP0005448_abnormal_energy_balance0.45424222
176MP0006276_abnormal_autonomic_nervous0.43267466
177MP0009115_abnormal_fat_cell0.43113743
178MP0005452_abnormal_adipose_tissue0.41571506
179MP0005408_hypopigmentation0.41135795
180MP0000358_abnormal_cell_content/0.39190240

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of fatty-acid metabolism (HP:0004359)4.83345735
2Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.45317836
3Hypoglycemic coma (HP:0001325)4.38678382
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.36027217
5Intrahepatic cholestasis (HP:0001406)4.26264598
6Ketosis (HP:0001946)4.20408352
7Hyperammonemia (HP:0001987)4.15659366
8Ketoacidosis (HP:0001993)4.06518678
9Myoglobinuria (HP:0002913)3.94407757
10Sudden death (HP:0001699)3.88509484
11Hepatic necrosis (HP:0002605)3.87732780
12Abnormality of dicarboxylic acid metabolism (HP:0010995)3.82561601
13Dicarboxylic aciduria (HP:0003215)3.82561601
14Hyperglycinuria (HP:0003108)3.69905935
15Deep venous thrombosis (HP:0002625)3.62292195
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.59695722
17Ventricular tachycardia (HP:0004756)3.57218288
18Hypobetalipoproteinemia (HP:0003563)3.54540783
19Cerebral edema (HP:0002181)3.51580795
20Xanthomatosis (HP:0000991)3.51157743
21Microvesicular hepatic steatosis (HP:0001414)3.43773343
22Rhabdomyolysis (HP:0003201)3.42333072
23Exercise-induced myalgia (HP:0003738)3.42110478
24Exercise-induced muscle cramps (HP:0003710)3.40983795
25Generalized aminoaciduria (HP:0002909)3.39971483
26Abnormality of serine family amino acid metabolism (HP:0010894)3.38366637
27Abnormality of glycine metabolism (HP:0010895)3.38366637
28Increased serum pyruvate (HP:0003542)3.35992701
29Abnormality of glycolysis (HP:0004366)3.35992701
30Increased hepatocellular lipid droplets (HP:0006565)3.34948067
31Palpitations (HP:0001962)3.34471594
32Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32578553
33Chromsome breakage (HP:0040012)3.24287070
34Colon cancer (HP:0003003)3.23418332
35Hepatocellular necrosis (HP:0001404)3.21317045
36Calf muscle hypertrophy (HP:0008981)3.19664514
37Hyperlipoproteinemia (HP:0010980)3.10790681
38Hyperglycinemia (HP:0002154)3.09642234
39Metabolic acidosis (HP:0001942)3.09605243
40Acute encephalopathy (HP:0006846)3.02928574
41Increased muscle lipid content (HP:0009058)2.97476995
42Abnormality of the labia minora (HP:0012880)2.96775086
43Lethargy (HP:0001254)2.91731907
44Prolonged partial thromboplastin time (HP:0003645)2.90129018
45Hypolipoproteinemia (HP:0010981)2.88229495
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87396996
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87396996
48Abnormal mitochondria in muscle tissue (HP:0008316)2.86490933
49Type I transferrin isoform profile (HP:0003642)2.85164184
50Aplastic anemia (HP:0001915)2.83178667
51Abnormal lung lobation (HP:0002101)2.82249315
52Muscle hypertrophy of the lower extremities (HP:0008968)2.77341511
53Lipoatrophy (HP:0100578)2.74384512
54Delayed CNS myelination (HP:0002188)2.73084796
55Neuroendocrine neoplasm (HP:0100634)2.72786342
56Lactic acidosis (HP:0003128)2.72674461
57Meckel diverticulum (HP:0002245)2.72231803
58Abnormality of chromosome stability (HP:0003220)2.71696827
59Proximal tubulopathy (HP:0000114)2.71495040
60Acute necrotizing encephalopathy (HP:0006965)2.68974461
61Abnormality of the preputium (HP:0100587)2.67178205
62Hypoalphalipoproteinemia (HP:0003233)2.66986451
63Reticulocytopenia (HP:0001896)2.65808924
64Increased CSF lactate (HP:0002490)2.65600284
65Mitochondrial inheritance (HP:0001427)2.62438783
66Lipid accumulation in hepatocytes (HP:0006561)2.62329815
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.61863091
68Atrial fibrillation (HP:0005110)2.61528271
69Renal cortical cysts (HP:0000803)2.61410219
70Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.60927447
71Vomiting (HP:0002013)2.59875547
72Gout (HP:0001997)2.59015990
73Hyperbilirubinemia (HP:0002904)2.58547813
74Prolonged QT interval (HP:0001657)2.58509179
75Dilated cardiomyopathy (HP:0001644)2.56905735
76Abnormality of the ileum (HP:0001549)2.56591653
77Birth length less than 3rd percentile (HP:0003561)2.56249987
78Megaloblastic anemia (HP:0001889)2.56016086
79Macrocytic anemia (HP:0001972)2.54651066
80Right ventricular cardiomyopathy (HP:0011663)2.53766155
81Pheochromocytoma (HP:0002666)2.51748429
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.51628536
83Abnormality of serum amino acid levels (HP:0003112)2.49504250
84Abnormality of glutamine family amino acid metabolism (HP:0010902)2.49057069
85Methylmalonic acidemia (HP:0002912)2.47836372
86Aplasia/Hypoplasia of the uvula (HP:0010293)2.47380643
87Aplasia/Hypoplasia of the sacrum (HP:0008517)2.46306146
88Abnormality of purine metabolism (HP:0004352)2.42323765
89Ragged-red muscle fibers (HP:0003200)2.41480033
90Nausea (HP:0002018)2.39384338
91Duodenal stenosis (HP:0100867)2.38345456
92Small intestinal stenosis (HP:0012848)2.38345456
93Primary atrial arrhythmia (HP:0001692)2.38039829
94Reduced antithrombin III activity (HP:0001976)2.37734507
95Increased intramyocellular lipid droplets (HP:0012240)2.37528068
96Conjunctival hamartoma (HP:0100780)2.37091344
97Conjugated hyperbilirubinemia (HP:0002908)2.36145152
98Premature ovarian failure (HP:0008209)2.35469163
99Complement deficiency (HP:0004431)2.33554309
100Supraventricular tachycardia (HP:0004755)2.31840334
101Multiple enchondromatosis (HP:0005701)2.31453227
102Abnormality of alanine metabolism (HP:0010916)2.31076646
103Hyperalaninemia (HP:0003348)2.31076646
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31076646
105Abnormality of nucleobase metabolism (HP:0010932)2.30945632
106Abnormality of methionine metabolism (HP:0010901)2.29974087
107Abnormal protein N-linked glycosylation (HP:0012347)2.29453913
108Abnormal protein glycosylation (HP:0012346)2.29453913
109Abnormal glycosylation (HP:0012345)2.29453913
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29453913
111Hyporeflexia of lower limbs (HP:0002600)2.28864655
112Abnormality of urine glucose concentration (HP:0011016)2.28647064
113Glycosuria (HP:0003076)2.28647064
114Septo-optic dysplasia (HP:0100842)2.28008965
115Abnormality of the intrinsic pathway (HP:0010989)2.27960536
116Renal Fanconi syndrome (HP:0001994)2.27746566
117Cholelithiasis (HP:0001081)2.27035878
118Abnormality of the common coagulation pathway (HP:0010990)2.26359806
119Abnormality of the calf musculature (HP:0001430)2.25800648
120Respiratory difficulties (HP:0002880)2.25248856
121Fat malabsorption (HP:0002630)2.25079961
122Hyperinsulinemic hypoglycemia (HP:0000825)2.24236771
123Supraventricular arrhythmia (HP:0005115)2.23819580
124Leukodystrophy (HP:0002415)2.23467349
125Syncope (HP:0001279)2.22524333
126Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21985638
127Epidermoid cyst (HP:0200040)2.21806879
128Respiratory failure (HP:0002878)2.20993839
129Progressive macrocephaly (HP:0004481)2.20328501
130Progressive muscle weakness (HP:0003323)2.19819309
131Abnormal gallbladder morphology (HP:0012437)2.17642529
132Opisthotonus (HP:0002179)2.15718671
133Nephroblastoma (Wilms tumor) (HP:0002667)2.15588924
134Neonatal death (HP:0003811)2.14768982
135Abnormality of the left ventricular outflow tract (HP:0011103)2.13866789
136Subaortic stenosis (HP:0001682)2.13866789
137Increased serum lactate (HP:0002151)2.12828109
138CNS demyelination (HP:0007305)2.12260269
139Pancytopenia (HP:0001876)2.11688505
140Exercise intolerance (HP:0003546)2.11553383
141Cerebral hypomyelination (HP:0006808)2.11012770
142Nemaline bodies (HP:0003798)2.10903272
143Pancreatic islet-cell hyperplasia (HP:0004510)2.10372467
144Neoplasm of the adrenal gland (HP:0100631)2.09604370
145Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08976528
146Oral leukoplakia (HP:0002745)2.08515312
147Abnormality of homocysteine metabolism (HP:0010919)2.07561647
148Homocystinuria (HP:0002156)2.07561647
149Absent thumb (HP:0009777)2.06072853
150Methylmalonic aciduria (HP:0012120)2.05955552
151Abnormality of the duodenum (HP:0002246)2.05494319
152Myelodysplasia (HP:0002863)2.04594654
153Embryonal renal neoplasm (HP:0011794)1.97571289
154Testicular atrophy (HP:0000029)1.93060891
155Muscle fiber inclusion bodies (HP:0100299)1.92159872
156Absent septum pellucidum (HP:0001331)1.92063976
157Abnormality of cells of the erythroid lineage (HP:0012130)1.91744924
158Abnormal umbilical cord blood vessels (HP:0011403)1.91619861
159Single umbilical artery (HP:0001195)1.91619861
160Abnormality of the fetal cardiovascular system (HP:0010948)1.91619861
161Neoplasm of the colon (HP:0100273)1.91146069
162Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.88730815
163Secondary amenorrhea (HP:0000869)1.88414005
164Supernumerary spleens (HP:0009799)1.85772595
165Abnormality of the anterior horn cell (HP:0006802)1.85494056
166Degeneration of anterior horn cells (HP:0002398)1.85494056
167Abnormal spermatogenesis (HP:0008669)1.84322236
168Abnormal number of erythroid precursors (HP:0012131)1.82464887
169Horseshoe kidney (HP:0000085)1.81968365
170Sloping forehead (HP:0000340)1.80793450
171Shoulder girdle muscle weakness (HP:0003547)1.79029146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K7.71457166
2MAPKAPK37.29066486
3BUB15.32384144
4BCKDK4.90716361
5VRK23.79370543
6CDC73.23799143
7PBK3.20710612
8TRPM73.12105893
9EIF2AK12.96178050
10STK162.88896986
11SRPK12.83910879
12PDK42.69869800
13PDK32.69869800
14PLK32.38543357
15MST42.35462256
16VRK12.32416299
17TTN2.32036154
18RPS6KB22.22456820
19OBSCN2.12038648
20NME12.10388477
21PKN22.09121968
22MYLK2.08947019
23NEK11.99949644
24MAPKAPK51.95621709
25WEE11.82108031
26MAPK111.75226799
27PLK41.72257925
28PLK11.69320164
29ERN11.62305610
30MAPK131.62238622
31PNCK1.60227376
32BRSK21.58610768
33NUAK11.54704797
34PHKG21.51614673
35PHKG11.51614673
36MAPK121.48490551
37LMTK21.46783323
38FLT31.45799177
39TAF11.43673265
40STK241.37726321
41MKNK11.37683985
42MKNK21.27723088
43STK38L1.26726486
44AURKB1.24082685
45ATR1.23329782
46SIK31.22933684
47NEK21.16359013
48TNIK1.13625693
49AURKA1.12413257
50RPS6KA21.12269674
51TXK1.12224601
52PINK11.11135228
53CHEK21.10186875
54MAP4K21.08411308
55EIF2AK21.08188927
56PRKAA11.07774054
57PDK21.07207594
58SIK11.06818502
59TRIB31.06161935
60CCNB11.00575888
61MAP2K40.98589993
62PRKAA20.97957708
63DMPK0.95452212
64TRIM280.95111830
65MAP2K30.93720837
66ZAK0.93582079
67DAPK10.93340829
68SGK20.93017903
69NEK90.92867618
70MAP3K100.92515352
71FGFR40.91640374
72CHEK10.87919411
73PASK0.84928666
74EIF2AK30.82866929
75TAOK30.80987536
76CDK190.80906471
77DAPK20.80470609
78CDK70.80097568
79STK390.78876486
80WNK30.78499276
81MAP3K80.78017347
82MAP3K50.76902623
83ATM0.73656066
84WNK40.72833316
85MAP3K90.72520135
86MAP3K30.72447687
87RPS6KB10.71590362
88RPS6KA40.71265000
89SGK4940.69510086
90SGK2230.69510086
91TIE10.67722413
92BRAF0.67394204
93CSNK2A20.66368879
94SGK30.66273262
95INSRR0.66204707
96STK40.62123888
97ALK0.61976629
98OXSR10.58932483
99BMPR1B0.58152662
100CSNK2A10.58029925
101SCYL20.56555930
102CSNK1G10.55666632
103MAP3K120.54636208
104ERBB30.52935332
105MAP3K70.52060044
106MAPKAPK20.51319964
107ARAF0.51286815
108PAK40.50919314
109TGFBR20.50479634
110AKT30.50016200
111CSNK1E0.49433338
112STK30.48434819
113CDK20.48125468
114MTOR0.47959388
115KDR0.47758518
116CDK10.46771966
117TESK20.46460861
118DYRK30.45360283
119PAK10.44733361
120MAP3K60.44472656
121MELK0.42739455
122TSSK60.42612282
123GRK70.41368947
124CLK10.41036260
125TBK10.40975959
126MAP4K10.39675529
127PIK3CA0.39480268
128CDK40.36820754
129DYRK20.36079982
130ERBB40.35696743
131MAPK40.33783559
132PRKD10.33621614
133BRSK10.32315454
134CAMK40.32024632
135MAP3K110.31664780
136RPS6KA10.31226124
137CAMK2D0.31101437
138CDK90.29912560
139PRKCI0.29869799
140TLK10.29587492
141PRKACG0.28841359
142CDK80.28649020
143MUSK0.28479270
144STK100.28383033
145PRKACB0.28010074
146RPS6KA50.26692931
147GRK60.24662926
148ACVR1B0.24089239
149CDC42BPA0.23682103
150MET0.22762406
151DAPK30.21973871
152RPS6KC10.21877696
153RPS6KL10.21877696
154PRKDC0.21751342
155PAK30.21520695
156RAF10.21454416
157ILK0.21064037
158PIK3CG0.20969823
159CSNK1A1L0.20281716
160TTK0.19702687
161CDK11A0.19005472
162CDK180.18713132
163PRKACA0.18590731
164RPS6KA60.17655929
165NME20.17141752
166PRKCQ0.16551682
167MAP2K10.15651487
168MAP2K70.15523032
169PRKCH0.14184394
170MARK20.13475972
171LRRK20.11312795
172ROCK10.10124075
173SYK0.08749372
174CSNK1G30.08476218

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.96412565
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.81686361
3DNA replication_Homo sapiens_hsa030303.77949950
4Mismatch repair_Homo sapiens_hsa034303.75629020
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.50443347
6Fatty acid degradation_Homo sapiens_hsa000713.16985433
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.15211879
8Propanoate metabolism_Homo sapiens_hsa006403.13893890
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.07628798
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06481486
11Ribosome_Homo sapiens_hsa030103.00859012
12RNA polymerase_Homo sapiens_hsa030202.98146227
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.93594361
14Homologous recombination_Homo sapiens_hsa034402.68857443
15Butanoate metabolism_Homo sapiens_hsa006502.63629753
16Base excision repair_Homo sapiens_hsa034102.55314559
17Fatty acid metabolism_Homo sapiens_hsa012122.49899549
18Pyruvate metabolism_Homo sapiens_hsa006202.49636593
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48248676
20Tryptophan metabolism_Homo sapiens_hsa003802.35624151
21Carbon metabolism_Homo sapiens_hsa012002.34600056
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.33660427
23Spliceosome_Homo sapiens_hsa030402.26557932
24RNA transport_Homo sapiens_hsa030132.26124956
25Arginine biosynthesis_Homo sapiens_hsa002202.24153102
26Nucleotide excision repair_Homo sapiens_hsa034202.20727528
27Peroxisome_Homo sapiens_hsa041462.09968942
28Fanconi anemia pathway_Homo sapiens_hsa034602.03210934
29Cell cycle_Homo sapiens_hsa041102.02669571
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02157435
31Basal transcription factors_Homo sapiens_hsa030221.96701643
32RNA degradation_Homo sapiens_hsa030181.94570679
33Fatty acid elongation_Homo sapiens_hsa000621.85368759
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84021298
35PPAR signaling pathway_Homo sapiens_hsa033201.80382276
36beta-Alanine metabolism_Homo sapiens_hsa004101.72513792
37Biosynthesis of amino acids_Homo sapiens_hsa012301.72106999
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71015122
39Sulfur metabolism_Homo sapiens_hsa009201.51766128
40Phenylalanine metabolism_Homo sapiens_hsa003601.50477828
41Nitrogen metabolism_Homo sapiens_hsa009101.49875332
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46746556
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46428090
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.38161594
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.36802976
46Oxidative phosphorylation_Homo sapiens_hsa001901.32294565
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30971418
48Complement and coagulation cascades_Homo sapiens_hsa046101.30203212
49Starch and sucrose metabolism_Homo sapiens_hsa005001.29103612
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27751676
51Parkinsons disease_Homo sapiens_hsa050121.26709710
52Selenocompound metabolism_Homo sapiens_hsa004501.18294251
53Tyrosine metabolism_Homo sapiens_hsa003501.16659015
54Histidine metabolism_Homo sapiens_hsa003401.14937240
55mRNA surveillance pathway_Homo sapiens_hsa030151.14683227
56Oocyte meiosis_Homo sapiens_hsa041141.09485830
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08636813
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07117572
59Fructose and mannose metabolism_Homo sapiens_hsa000511.05923779
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04381684
61Cardiac muscle contraction_Homo sapiens_hsa042601.02732100
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02637102
63Chemical carcinogenesis_Homo sapiens_hsa052041.02285685
64Arginine and proline metabolism_Homo sapiens_hsa003300.99766147
65Folate biosynthesis_Homo sapiens_hsa007900.99063962
66Fat digestion and absorption_Homo sapiens_hsa049750.98190839
67Lysine degradation_Homo sapiens_hsa003100.96833662
68Bile secretion_Homo sapiens_hsa049760.94949258
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.94735849
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.91171371
71Retinol metabolism_Homo sapiens_hsa008300.89546231
72ABC transporters_Homo sapiens_hsa020100.89208871
73Caffeine metabolism_Homo sapiens_hsa002320.84091419
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81063940
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80026826
76Alzheimers disease_Homo sapiens_hsa050100.80023119
77Pentose phosphate pathway_Homo sapiens_hsa000300.79287080
78One carbon pool by folate_Homo sapiens_hsa006700.74731006
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73316702
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70629630
81p53 signaling pathway_Homo sapiens_hsa041150.70002936
82Glycerolipid metabolism_Homo sapiens_hsa005610.68163325
83Metabolic pathways_Homo sapiens_hsa011000.66648839
84Huntingtons disease_Homo sapiens_hsa050160.63330012
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59159528
86Staphylococcus aureus infection_Homo sapiens_hsa051500.59016106
87Glutathione metabolism_Homo sapiens_hsa004800.55900213
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54698448
89Insulin resistance_Homo sapiens_hsa049310.52991954
90Sulfur relay system_Homo sapiens_hsa041220.50397043
91Epstein-Barr virus infection_Homo sapiens_hsa051690.49703866
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49700133
93Fatty acid biosynthesis_Homo sapiens_hsa000610.49341446
94Regulation of autophagy_Homo sapiens_hsa041400.48874201
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.47029371
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44874720
97Galactose metabolism_Homo sapiens_hsa000520.44097236
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42958724
99Dilated cardiomyopathy_Homo sapiens_hsa054140.41033995
100Glucagon signaling pathway_Homo sapiens_hsa049220.40926431
101Vitamin digestion and absorption_Homo sapiens_hsa049770.39752580
102N-Glycan biosynthesis_Homo sapiens_hsa005100.35039123
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31806305
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.29701675
105Vitamin B6 metabolism_Homo sapiens_hsa007500.29211964
106Steroid biosynthesis_Homo sapiens_hsa001000.25973995
107Insulin signaling pathway_Homo sapiens_hsa049100.25419225
108Systemic lupus erythematosus_Homo sapiens_hsa053220.23583281
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18712696
110AMPK signaling pathway_Homo sapiens_hsa041520.18204910
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16871574
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13193992
113Viral carcinogenesis_Homo sapiens_hsa052030.12610568
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10392583
115Linoleic acid metabolism_Homo sapiens_hsa005910.09351942
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.08387058
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07800179
118Non-homologous end-joining_Homo sapiens_hsa034500.07483423
119Protein export_Homo sapiens_hsa030600.07211251
120Collecting duct acid secretion_Homo sapiens_hsa049660.04506883
121Wnt signaling pathway_Homo sapiens_hsa043100.03964657
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.03513885
123Alcoholism_Homo sapiens_hsa050340.03404118
124Thyroid cancer_Homo sapiens_hsa052160.03295759
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02398179
126HTLV-I infection_Homo sapiens_hsa051660.01626839
127Herpes simplex infection_Homo sapiens_hsa051680.00580973
128Pyrimidine metabolism_Homo sapiens_hsa002400.00341143
129Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0998552
130Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0823605
131Purine metabolism_Homo sapiens_hsa00230-0.0667279
132Proteasome_Homo sapiens_hsa03050-0.0416932
133Viral myocarditis_Homo sapiens_hsa05416-0.0394433
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0063450

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