RTN4R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.99794763
2synaptic vesicle maturation (GO:0016188)6.96090507
3glycine transport (GO:0015816)6.90428512
4locomotory exploration behavior (GO:0035641)6.58959701
5cell migration in hindbrain (GO:0021535)6.42527594
6synaptic vesicle docking involved in exocytosis (GO:0016081)6.39464986
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.26986354
8glutamate secretion (GO:0014047)6.26403340
9establishment of mitochondrion localization (GO:0051654)6.12094846
10nonmotile primary cilium assembly (GO:0035058)6.04714842
11respiratory system process (GO:0003016)5.95800964
12synaptic vesicle exocytosis (GO:0016079)5.88666434
13vocalization behavior (GO:0071625)5.82629570
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.79923337
15amine catabolic process (GO:0009310)5.69988410
16cellular biogenic amine catabolic process (GO:0042402)5.69988410
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.67736459
18establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.66772747
19mitochondrion transport along microtubule (GO:0047497)5.66772747
20regulation of synaptic vesicle exocytosis (GO:2000300)5.50664913
21regulation of glutamate receptor signaling pathway (GO:1900449)5.36131044
22telomere maintenance via semi-conservative replication (GO:0032201)5.22336274
23protein localization to synapse (GO:0035418)5.17314181
24exploration behavior (GO:0035640)5.11602123
25otic vesicle formation (GO:0030916)5.06608764
26regulation of synaptic vesicle transport (GO:1902803)5.02622432
27calcium-mediated signaling using intracellular calcium source (GO:0035584)5.02461945
28ionotropic glutamate receptor signaling pathway (GO:0035235)4.93829656
29regulation of neuronal synaptic plasticity (GO:0048168)4.93783533
30axon extension (GO:0048675)4.91645722
31cell differentiation in hindbrain (GO:0021533)4.91064405
32neuronal action potential propagation (GO:0019227)4.87993408
33DNA replication initiation (GO:0006270)4.79943908
34regulation of long-term neuronal synaptic plasticity (GO:0048169)4.70488067
35synaptic transmission, glutamatergic (GO:0035249)4.61544734
36neurotransmitter secretion (GO:0007269)4.52496219
37neuron projection extension (GO:1990138)4.45040585
38dendritic spine morphogenesis (GO:0060997)4.37740145
39glutamate receptor signaling pathway (GO:0007215)4.37251088
40positive regulation of synapse maturation (GO:0090129)4.37198546
41glycosphingolipid biosynthetic process (GO:0006688)4.36933039
42neurotransmitter-gated ion channel clustering (GO:0072578)4.36689171
43layer formation in cerebral cortex (GO:0021819)4.33744878
44sodium ion export (GO:0071436)4.32671168
45cellular potassium ion homeostasis (GO:0030007)4.31876014
46regulation of synapse structural plasticity (GO:0051823)4.28686723
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.24975038
48long-term memory (GO:0007616)4.24784104
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.22103238
50telomere maintenance via recombination (GO:0000722)4.21380310
51positive regulation of membrane potential (GO:0045838)4.18552983
52cytokinetic process (GO:0032506)4.14741497
53neuron cell-cell adhesion (GO:0007158)4.14522169
54proline transport (GO:0015824)4.09781096
55cell communication by electrical coupling (GO:0010644)4.06358196
56regulation of excitatory postsynaptic membrane potential (GO:0060079)4.05110420
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.01780334
58ganglioside metabolic process (GO:0001573)4.01286612
59oligosaccharide biosynthetic process (GO:0009312)4.00558430
60neuron-neuron synaptic transmission (GO:0007270)3.96269350
61regulation of synaptic plasticity (GO:0048167)3.92817256
62urinary tract smooth muscle contraction (GO:0014848)3.85852191
63hematopoietic stem cell differentiation (GO:0060218)3.82240544
64regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.81507042
65regulation of postsynaptic membrane potential (GO:0060078)3.81174660
66glial cell migration (GO:0008347)3.78704023
67activation of protein kinase A activity (GO:0034199)3.72484650
68regulation of dendritic spine morphogenesis (GO:0061001)3.72071362
69regulation of neurotransmitter secretion (GO:0046928)3.68726862
70polyamine metabolic process (GO:0006595)3.58881828
71neuron remodeling (GO:0016322)3.55321775
72gamma-aminobutyric acid transport (GO:0015812)3.54905429
73neuromuscular process controlling balance (GO:0050885)3.53776221
74negative regulation of transcription by competitive promoter binding (GO:0010944)3.51728622
75synaptic vesicle endocytosis (GO:0048488)3.50492007
76neurotransmitter transport (GO:0006836)3.50220890
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.49917688
78long-term synaptic potentiation (GO:0060291)3.49634046
79dendritic spine organization (GO:0097061)3.49437990
80mitotic recombination (GO:0006312)3.48581038
81cerebellar granule cell differentiation (GO:0021707)3.48459997
82positive regulation of neurotransmitter secretion (GO:0001956)3.47978144
83cerebellar Purkinje cell differentiation (GO:0021702)3.47638800
84skeletal muscle organ development (GO:0060538)3.47478623
85maintenance of protein location in nucleus (GO:0051457)3.44313793
86pyrimidine nucleobase catabolic process (GO:0006208)3.42117481
87cytoskeleton-dependent cytokinesis (GO:0061640)3.40095705
88regulation of vesicle fusion (GO:0031338)3.38451125
89positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.37290160
90regulation of ARF protein signal transduction (GO:0032012)3.36505505
91postsynaptic membrane organization (GO:0001941)3.34011473
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.33545959
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.32092578
94neuron recognition (GO:0008038)3.31861442
95positive regulation of dendritic spine development (GO:0060999)3.29842987
96regulation of neurotransmitter levels (GO:0001505)3.27196978
97regulation of synapse maturation (GO:0090128)3.26112426
98genetic imprinting (GO:0071514)3.25737896
99regulation of neurotransmitter transport (GO:0051588)3.25061527
100positive regulation of filopodium assembly (GO:0051491)3.24923700
101axonal fasciculation (GO:0007413)3.24235943
102chemosensory behavior (GO:0007635)3.23717033
103innervation (GO:0060384)3.23671387
104membrane depolarization (GO:0051899)3.23271817
105cellular sodium ion homeostasis (GO:0006883)3.22842989
106regulation of ruffle assembly (GO:1900027)3.22811708
107regulation of dendritic spine development (GO:0060998)3.21262610
108potassium ion homeostasis (GO:0055075)3.21014599
109neuromuscular process controlling posture (GO:0050884)3.20099869
110cornea development in camera-type eye (GO:0061303)3.19934896
111cell morphogenesis involved in neuron differentiation (GO:0048667)3.19622559
112gamma-aminobutyric acid signaling pathway (GO:0007214)3.19291269
113dendrite morphogenesis (GO:0048813)3.18611722
114regulation of synaptic transmission, glutamatergic (GO:0051966)3.17736106
115membrane depolarization during action potential (GO:0086010)3.17728217
116developmental cell growth (GO:0048588)3.17718680
117regulation of cilium movement (GO:0003352)3.16422622
118positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.15838831
119cardiovascular system development (GO:0072358)3.14877422
120L-amino acid import (GO:0043092)3.14764368
121suckling behavior (GO:0001967)3.14353039
122regulation of synaptic transmission (GO:0050804)3.12455187
123auditory behavior (GO:0031223)3.11740311
124DNA strand elongation involved in DNA replication (GO:0006271)3.09849551
125positive regulation of fibroblast migration (GO:0010763)3.09714666
126positive regulation of dendritic spine morphogenesis (GO:0061003)3.07182540
127nucleobase catabolic process (GO:0046113)3.06800594
128regulation of voltage-gated calcium channel activity (GO:1901385)3.06306106
129regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.04247246
130protein-cofactor linkage (GO:0018065)3.04129421
131negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04017062
132regulation of microtubule-based movement (GO:0060632)3.03241818
133positive regulation of protein kinase C signaling (GO:0090037)3.02467398
134positive regulation of neurotransmitter transport (GO:0051590)3.01904397
135mechanosensory behavior (GO:0007638)3.00963853
136positive regulation of synaptic transmission (GO:0050806)3.00691620
137cerebellar Purkinje cell layer development (GO:0021680)3.00330596
138regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.99472772
139negative regulation of response to food (GO:0032096)2.99169783
140negative regulation of appetite (GO:0032099)2.99169783
141telomere maintenance via telomere lengthening (GO:0010833)2.98774317
142body morphogenesis (GO:0010171)2.97973333
143potassium ion import (GO:0010107)2.96096002
144learning (GO:0007612)2.95831157
145cell communication involved in cardiac conduction (GO:0086065)2.95809802
146synaptic transmission (GO:0007268)2.95395461
147substrate-independent telencephalic tangential migration (GO:0021826)2.94275210
148substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.94275210
149forebrain neuron differentiation (GO:0021879)2.94064727
150neuromuscular process (GO:0050905)2.93845873
151neuronal ion channel clustering (GO:0045161)2.93213150
152vesicle docking (GO:0048278)2.93034296
153intraspecies interaction between organisms (GO:0051703)2.92825480
154social behavior (GO:0035176)2.92825480
155protein localization to microtubule cytoskeleton (GO:0072698)2.91983356
156ephrin receptor signaling pathway (GO:0048013)2.91503367
157regulation of ion transmembrane transporter activity (GO:0032412)2.90879706
158axon cargo transport (GO:0008088)2.89498579
159long term synaptic depression (GO:0060292)2.88846799
160response to auditory stimulus (GO:0010996)2.88748924
161DNA strand elongation (GO:0022616)2.88065432
162membrane hyperpolarization (GO:0060081)2.87831654
163vesicle docking involved in exocytosis (GO:0006904)2.81932069
164axon ensheathment in central nervous system (GO:0032291)2.78837804
165central nervous system myelination (GO:0022010)2.78837804
166negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.78665000
167protein localization to cytoskeleton (GO:0044380)2.74633274
168embryonic body morphogenesis (GO:0010172)2.74602198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.89018120
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.36530867
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23081933
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19471286
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12362692
6GBX2_23144817_ChIP-Seq_PC3_Human2.94863572
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.93152562
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.92305632
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.90689710
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.90689710
11DROSHA_22980978_ChIP-Seq_HELA_Human2.86874103
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.82932057
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.69650953
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.66144436
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65865317
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.61189736
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.56969219
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54740664
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.53088195
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49262066
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.47058825
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.45990182
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.43105877
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42121610
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.41985299
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.34981847
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.24079004
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03417238
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.80993297
30RNF2_27304074_Chip-Seq_NSC_Mouse1.80867649
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80814500
32AR_21572438_ChIP-Seq_LNCaP_Human1.67331158
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63377783
34VDR_22108803_ChIP-Seq_LS180_Human1.63052750
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62212090
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57889796
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48812161
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48410158
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.47346607
40* KDM2B_26808549_Chip-Seq_K562_Human1.45173592
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44448790
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44252505
43ZNF274_21170338_ChIP-Seq_K562_Hela1.43463699
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41048113
45* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40288865
46POU5F1_16518401_ChIP-PET_MESCs_Mouse1.39229173
47SMAD4_21799915_ChIP-Seq_A2780_Human1.37380444
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37199323
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36739856
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36739856
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34098866
52SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32807228
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32511621
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30058020
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24424366
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.24312523
57MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23726607
58* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23479235
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23456740
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23405816
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22841121
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22800778
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22191055
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20381995
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20001279
66AR_19668381_ChIP-Seq_PC3_Human1.19768055
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17239030
68CREB1_26743006_Chip-Seq_LNCaP_Human1.17014106
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14172935
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.13907612
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.13550157
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.12187746
73AR_25329375_ChIP-Seq_VCAP_Human1.11286283
74RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10666822
75P68_20966046_ChIP-Seq_HELA_Human1.08887349
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08709057
77CTCF_27219007_Chip-Seq_Bcells_Human1.07636065
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06980519
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06396204
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.05796641
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05787779
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05646681
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02907769
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02809111
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02036243
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01569903
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01044885
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00290603
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99203491
90DPY_21335234_ChIP-Seq_ESCs_Mouse0.98271886
91SMAD_19615063_ChIP-ChIP_OVARY_Human0.97831492
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.97192373
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97034075
94* LXR_22292898_ChIP-Seq_THP-1_Human0.96684859
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.94627863
96YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93429536
97SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92591924
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92475462
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.92229411
100* FOXP1_21924763_ChIP-Seq_HESCs_Human0.92022050
101STAT3_23295773_ChIP-Seq_U87_Human0.91931236
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91900725
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91753624
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.91742557
105HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89841347
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89657312
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.89050206
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88529733
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88488643
110* PHF8_20622854_ChIP-Seq_HELA_Human0.88414569
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.87982133
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87759557
113RXR_22108803_ChIP-Seq_LS180_Human0.87635835
114AHR_22903824_ChIP-Seq_MCF-7_Human0.87200592
115SMC4_20622854_ChIP-Seq_HELA_Human0.86922470
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.85603603
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84530916
118NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84423374
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83686853
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83248457
121TCF4_23295773_ChIP-Seq_U87_Human0.83071902
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82759089
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.82475833
124P300_19829295_ChIP-Seq_ESCs_Human0.82352983
125GATA1_26923725_Chip-Seq_HPCs_Mouse0.82172810
126CBX2_27304074_Chip-Seq_ESCs_Mouse0.82159261
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81903802
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81857087
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81311539
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80677000
131TP53_16413492_ChIP-PET_HCT116_Human0.80460118
132KLF4_19829295_ChIP-Seq_ESCs_Human0.80068668
133OCT4_19829295_ChIP-Seq_ESCs_Human0.79832195
134OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.78771390
135CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78728265
136KDM2B_26808549_Chip-Seq_DND41_Human0.77508256
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.77072116
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.76966804
139SMAD4_21741376_ChIP-Seq_ESCs_Human0.76697656
140SOX3_22085726_ChIP-Seq_NPCs_Mouse0.76560785
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75938002
142* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75852369
143OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75359334
144TAF2_19829295_ChIP-Seq_ESCs_Human0.75144690
145REST_19997604_ChIP-ChIP_NEURONS_Mouse0.74575383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity8.08288519
2MP0003880_abnormal_central_pattern4.59433592
3MP0003635_abnormal_synaptic_transmissio4.48854968
4MP0004270_analgesia4.01720234
5* MP0002063_abnormal_learning/memory/cond3.46793933
6MP0009745_abnormal_behavioral_response3.43561432
7MP0002064_seizures3.20862438
8MP0001968_abnormal_touch/_nociception3.04095763
9MP0009046_muscle_twitch2.96045147
10MP0003121_genomic_imprinting2.88966074
11* MP0002572_abnormal_emotion/affect_behav2.73141270
12MP0002734_abnormal_mechanical_nocicepti2.66554592
13MP0000013_abnormal_adipose_tissue2.63029376
14MP0002272_abnormal_nervous_system2.54973391
15MP0005423_abnormal_somatic_nervous2.53778882
16MP0002735_abnormal_chemical_nociception2.46253957
17MP0002736_abnormal_nociception_after2.44506501
18MP0003123_paternal_imprinting2.35847061
19MP0001486_abnormal_startle_reflex2.33307897
20MP0001501_abnormal_sleep_pattern2.26277844
21MP0008569_lethality_at_weaning2.21032279
22MP0003329_amyloid_beta_deposits2.14160546
23MP0001440_abnormal_grooming_behavior2.13014396
24MP0009780_abnormal_chondrocyte_physiolo2.11182825
25MP0002822_catalepsy2.05513618
26MP0003879_abnormal_hair_cell1.95422659
27MP0002733_abnormal_thermal_nociception1.92922977
28MP0008260_abnormal_autophagy1.92920009
29MP0001970_abnormal_pain_threshold1.90551531
30MP0004811_abnormal_neuron_physiology1.89980950
31MP0001986_abnormal_taste_sensitivity1.88458491
32MP0002067_abnormal_sensory_capabilities1.83109072
33MP0001529_abnormal_vocalization1.81332101
34MP0002653_abnormal_ependyma_morphology1.77076727
35MP0000751_myopathy1.74535891
36MP0002184_abnormal_innervation1.70755498
37MP0000778_abnormal_nervous_system1.67511734
38MP0002909_abnormal_adrenal_gland1.61759938
39MP0002557_abnormal_social/conspecific_i1.60596778
40MP0005394_taste/olfaction_phenotype1.60560534
41MP0005499_abnormal_olfactory_system1.60560534
42MP0006292_abnormal_olfactory_placode1.59421706
43MP0004924_abnormal_behavior1.57455833
44MP0005386_behavior/neurological_phenoty1.57455833
45MP0008789_abnormal_olfactory_epithelium1.50886412
46MP0000372_irregular_coat_pigmentation1.50556127
47MP0005075_abnormal_melanosome_morpholog1.49966010
48MP0003136_yellow_coat_color1.46973997
49MP0000955_abnormal_spinal_cord1.46889571
50MP0003633_abnormal_nervous_system1.43104515
51MP0005409_darkened_coat_color1.42654747
52MP0002138_abnormal_hepatobiliary_system1.41078650
53* MP0004858_abnormal_nervous_system1.39999334
54* MP0002066_abnormal_motor_capabilities/c1.38927977
55MP0004885_abnormal_endolymph1.37788698
56MP0004215_abnormal_myocardial_fiber1.37368169
57* MP0002882_abnormal_neuron_morphology1.34871431
58MP0002837_dystrophic_cardiac_calcinosis1.33169018
59MP0001502_abnormal_circadian_rhythm1.29515581
60MP0004510_myositis1.28172324
61MP0003646_muscle_fatigue1.27272643
62MP0003631_nervous_system_phenotype1.21708474
63MP0000003_abnormal_adipose_tissue1.20816943
64MP0003385_abnormal_body_wall1.18190910
65MP0000015_abnormal_ear_pigmentation1.16993768
66MP0005551_abnormal_eye_electrophysiolog1.16147856
67MP0003787_abnormal_imprinting1.15005912
68MP0005174_abnormal_tail_pigmentation1.11918903
69MP0002928_abnormal_bile_duct1.11808150
70MP0004484_altered_response_of1.11123571
71MP0004145_abnormal_muscle_electrophysio1.08062784
72MP0002152_abnormal_brain_morphology1.07283130
73MP0003828_pulmonary_edema1.06274016
74MP0004142_abnormal_muscle_tone1.04445442
75MP0005646_abnormal_pituitary_gland1.04151942
76MP0006276_abnormal_autonomic_nervous1.03608767
77MP0008961_abnormal_basal_metabolism1.03594294
78MP0001324_abnormal_eye_pigmentation1.00772621
79MP0004085_abnormal_heartbeat0.99591446
80MP0001905_abnormal_dopamine_level0.98842499
81* MP0003075_altered_response_to0.98008613
82MP0003137_abnormal_impulse_conducting0.96435796
83MP0008872_abnormal_physiological_respon0.95051047
84MP0000604_amyloidosis0.91747175
85MP0001984_abnormal_olfaction0.90824458
86MP0008874_decreased_physiological_sensi0.90799041
87MP0002069_abnormal_eating/drinking_beha0.90773758
88MP0001853_heart_inflammation0.89037130
89MP0002163_abnormal_gland_morphology0.85825602
90MP0004233_abnormal_muscle_weight0.85586842
91MP0001943_abnormal_respiration0.85055563
92MP0005248_abnormal_Harderian_gland0.83831204
93MP0000569_abnormal_digit_pigmentation0.83273798
94MP0003632_abnormal_nervous_system0.83220902
95MP0002229_neurodegeneration0.81603914
96MP0002233_abnormal_nose_morphology0.79991544
97MP0005377_hearing/vestibular/ear_phenot0.77976649
98MP0003878_abnormal_ear_physiology0.77976649
99MP0002295_abnormal_pulmonary_circulatio0.77847497
100MP0005645_abnormal_hypothalamus_physiol0.77615425
101MP0005535_abnormal_body_temperature0.77098151
102MP0003283_abnormal_digestive_organ0.77004432
103MP0001177_atelectasis0.76619471
104MP0004130_abnormal_muscle_cell0.76494333
105* MP0003861_abnormal_nervous_system0.75469971
106MP0000026_abnormal_inner_ear0.73727731
107MP0000537_abnormal_urethra_morphology0.73301809
108MP0002877_abnormal_melanocyte_morpholog0.71943672
109MP0002081_perinatal_lethality0.70188635
110MP0001963_abnormal_hearing_physiology0.69973090
111MP0010234_abnormal_vibrissa_follicle0.69857109
112MP0005623_abnormal_meninges_morphology0.68926507
113MP0003634_abnormal_glial_cell0.67789431
114MP0000579_abnormal_nail_morphology0.67040444
115MP0000920_abnormal_myelination0.66910674
116MP0000747_muscle_weakness0.66723972
117MP0003172_abnormal_lysosome_physiology0.66425319
118MP0000647_abnormal_sebaceous_gland0.64806950
119MP0004084_abnormal_cardiac_muscle0.63972611
120MP0005620_abnormal_muscle_contractility0.63872723
121MP0001485_abnormal_pinna_reflex0.63500061
122MP0003690_abnormal_glial_cell0.62727183
123MP0003942_abnormal_urinary_system0.62697694
124MP0000462_abnormal_digestive_system0.62387895
125MP0010386_abnormal_urinary_bladder0.61538688
126MP0005167_abnormal_blood-brain_barrier0.60999842
127MP0002972_abnormal_cardiac_muscle0.60719722
128MP0001348_abnormal_lacrimal_gland0.59822201
129MP0002876_abnormal_thyroid_physiology0.58896044
130MP0001188_hyperpigmentation0.58298448
131MP0004036_abnormal_muscle_relaxation0.58185321
132MP0008770_decreased_survivor_rate0.57518084
133MP0002089_abnormal_postnatal_growth/wei0.57441124
134MP0004742_abnormal_vestibular_system0.57309131
135MP0002090_abnormal_vision0.56231512
136MP0009384_cardiac_valve_regurgitation0.56204015
137MP0003122_maternal_imprinting0.55472612
138MP0010769_abnormal_survival0.55406993
139MP0002234_abnormal_pharynx_morphology0.54692965
140MP0000749_muscle_degeneration0.54627974
141MP0001664_abnormal_digestion0.54308260
142MP0002752_abnormal_somatic_nervous0.53151275
143MP0005166_decreased_susceptibility_to0.52384363
144MP0010768_mortality/aging0.51955491
145MP0004043_abnormal_pH_regulation0.50556285

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)8.88081512
2Myokymia (HP:0002411)7.65873964
3Focal motor seizures (HP:0011153)7.57636882
4Polyphagia (HP:0002591)6.22262341
5Abnormality of the labia minora (HP:0012880)6.21672939
6Visual hallucinations (HP:0002367)5.87377031
7Abnormal hair whorl (HP:0010721)5.76166647
8Focal seizures (HP:0007359)5.74165552
9Gait imbalance (HP:0002141)5.54158137
10Oligomenorrhea (HP:0000876)5.25360568
11Epileptic encephalopathy (HP:0200134)4.99850242
12Congenital primary aphakia (HP:0007707)4.85861577
13Poor suck (HP:0002033)4.77030222
14Atonic seizures (HP:0010819)4.56100898
15Progressive cerebellar ataxia (HP:0002073)4.52373045
16Poor coordination (HP:0002370)4.48941865
17Action tremor (HP:0002345)4.34034717
18Nephrogenic diabetes insipidus (HP:0009806)4.27975095
19Medial flaring of the eyebrow (HP:0010747)4.21642317
20True hermaphroditism (HP:0010459)4.21106145
21Febrile seizures (HP:0002373)4.21084991
22Absence seizures (HP:0002121)4.01003179
23Pancreatic fibrosis (HP:0100732)3.91013695
24Hip dysplasia (HP:0001385)3.88295298
25Global brain atrophy (HP:0002283)3.86025094
26Generalized tonic-clonic seizures (HP:0002069)3.81569176
27Specific learning disability (HP:0001328)3.81276899
28Ventricular fibrillation (HP:0001663)3.71113927
29Dialeptic seizures (HP:0011146)3.66648143
30Poor eye contact (HP:0000817)3.63597964
31Broad-based gait (HP:0002136)3.62823153
32Bundle branch block (HP:0011710)3.61956737
33Gaze-evoked nystagmus (HP:0000640)3.60070937
34Impaired vibration sensation in the lower limbs (HP:0002166)3.55121043
35Sleep apnea (HP:0010535)3.54230359
36Abnormality of the lower motor neuron (HP:0002366)3.53877176
37Supranuclear gaze palsy (HP:0000605)3.53389497
38Ankle clonus (HP:0011448)3.40330070
39Depression (HP:0000716)3.39056790
40Vaginal atresia (HP:0000148)3.38578664
41Dysmetria (HP:0001310)3.32760139
42Cystic liver disease (HP:0006706)3.29483421
43Genetic anticipation (HP:0003743)3.28751686
44Pancreatic cysts (HP:0001737)3.28314391
45Dysdiadochokinesis (HP:0002075)3.25718892
46Postural instability (HP:0002172)3.25098422
47Mutism (HP:0002300)3.24706630
48Abnormal social behavior (HP:0012433)3.21125772
49Impaired social interactions (HP:0000735)3.21125772
50Papilledema (HP:0001085)3.20766058
51Genital tract atresia (HP:0001827)3.19741257
52Sclerocornea (HP:0000647)3.08593160
53Urinary bladder sphincter dysfunction (HP:0002839)3.08179686
54Abnormality of midbrain morphology (HP:0002418)3.08134577
55Molar tooth sign on MRI (HP:0002419)3.08134577
56Impaired smooth pursuit (HP:0007772)3.06866807
57Amblyopia (HP:0000646)3.04251123
58Dysmetric saccades (HP:0000641)2.99220825
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.97020889
60Generalized hypotonia (HP:0001290)2.96570513
61Abnormal eating behavior (HP:0100738)2.94831502
62Iris hypopigmentation (HP:0007730)2.90991112
63Hemiplegia (HP:0002301)2.88849426
64Urinary urgency (HP:0000012)2.87580767
65Anxiety (HP:0000739)2.86099196
66Annular pancreas (HP:0001734)2.85791474
67Nasal speech (HP:0001611)2.81517590
68Hyperventilation (HP:0002883)2.80501649
69Truncal ataxia (HP:0002078)2.77101030
70Obstructive sleep apnea (HP:0002870)2.76774019
71Vertebral clefting (HP:0008428)2.75785497
72Stereotypic behavior (HP:0000733)2.73386039
73Sudden death (HP:0001699)2.67709979
74Intention tremor (HP:0002080)2.64416292
75Abnormality of ocular smooth pursuit (HP:0000617)2.64184015
76Bradykinesia (HP:0002067)2.60255551
77Narrow nasal bridge (HP:0000446)2.56145353
78Focal dystonia (HP:0004373)2.55953561
79Hypogonadotrophic hypogonadism (HP:0000044)2.55079464
80Diplopia (HP:0000651)2.54017977
81Abnormality of binocular vision (HP:0011514)2.54017977
82Torticollis (HP:0000473)2.53808716
83Aplasia/Hypoplasia of the lens (HP:0008063)2.51924717
84Generalized hypopigmentation (HP:0007513)2.50723635
85Hemiparesis (HP:0001269)2.50583125
86Spastic gait (HP:0002064)2.50140552
87Labial hypoplasia (HP:0000066)2.44971535
88Nephronophthisis (HP:0000090)2.44414573
89Excessive salivation (HP:0003781)2.44185772
90Drooling (HP:0002307)2.44185772
91Impaired vibratory sensation (HP:0002495)2.39982984
92Epileptiform EEG discharges (HP:0011182)2.39045253
93Pointed chin (HP:0000307)2.37893996
94Megalencephaly (HP:0001355)2.36707689
95Cutaneous photosensitivity (HP:0000992)2.33030977
96Hypoventilation (HP:0002791)2.32759570
97Hypoplastic female external genitalia (HP:0012815)2.31456767
98Fetal akinesia sequence (HP:0001989)2.29709267
99Lower limb asymmetry (HP:0100559)2.26836001
100Cerebral inclusion bodies (HP:0100314)2.25553435
101Anencephaly (HP:0002323)2.24981368
102Scanning speech (HP:0002168)2.22479434
103EEG with generalized epileptiform discharges (HP:0011198)2.22230072
104Congenital stationary night blindness (HP:0007642)2.21651007
105Morphological abnormality of the middle ear (HP:0008609)2.20637635
106Syncope (HP:0001279)2.19850563
107Dyskinesia (HP:0100660)2.18887719
108Decreased muscle mass (HP:0003199)2.17102316
109Abnormal EKG (HP:0003115)2.16853416
110Insomnia (HP:0100785)2.16069785
111Neurofibrillary tangles (HP:0002185)2.15291287
112Frequent falls (HP:0002359)2.14601520
113Hypsarrhythmia (HP:0002521)2.13206068
114Decreased testicular size (HP:0008734)2.12450377
115Status epilepticus (HP:0002133)2.11891419
116Craniofacial dystonia (HP:0012179)2.11765353
117Broad foot (HP:0001769)2.11745634
118Delusions (HP:0000746)2.11089268
119Precocious puberty (HP:0000826)2.10576768
120Cerebral hypomyelination (HP:0006808)2.10438782
121Lower limb hyperreflexia (HP:0002395)2.09942457
122Postaxial foot polydactyly (HP:0001830)2.09053300
123Scrotal hypoplasia (HP:0000046)2.07793815
124Rapidly progressive (HP:0003678)2.07654558
125Deep palmar crease (HP:0006191)2.05937310
126Incomplete penetrance (HP:0003829)2.03306429
127Apathy (HP:0000741)2.02766534
128Lower limb muscle weakness (HP:0007340)2.02653465
129Spinal canal stenosis (HP:0003416)2.02166925
130Progressive inability to walk (HP:0002505)2.00880732
131Generalized myoclonic seizures (HP:0002123)2.00510809
132Cortical dysplasia (HP:0002539)1.99742075
133Abnormal rod and cone electroretinograms (HP:0008323)1.98780536
134Abnormality of saccadic eye movements (HP:0000570)1.98707933
135Left ventricular hypertrophy (HP:0001712)1.97459185
136Absent speech (HP:0001344)1.96673728
137Esophageal atresia (HP:0002032)1.96063410
138Amyotrophic lateral sclerosis (HP:0007354)1.94037701
139Termporal pattern (HP:0011008)1.93426923
140Insidious onset (HP:0003587)1.93426923
141Abnormality of the corticospinal tract (HP:0002492)1.93420621
142Gait ataxia (HP:0002066)1.92076532
143Akinesia (HP:0002304)1.90962432
144Spastic tetraplegia (HP:0002510)1.90763795
145Heart block (HP:0012722)1.89690388
146Ventricular arrhythmia (HP:0004308)1.89429742
147Myotonia (HP:0002486)1.88875460
148Lip pit (HP:0100267)1.87798150
149Intellectual disability, profound (HP:0002187)1.86164125
150Rigidity (HP:0002063)1.85356778
151Short foot (HP:0001773)1.84996604
152Lower limb amyotrophy (HP:0007210)1.84184453
153Inability to walk (HP:0002540)1.83916633
154Inappropriate behavior (HP:0000719)1.82986227
155Pheochromocytoma (HP:0002666)1.82444638
156Exercise-induced myalgia (HP:0003738)1.80373201
157Astigmatism (HP:0000483)1.80225257
158Preaxial hand polydactyly (HP:0001177)1.80106230
159Abnormality of the periventricular white matter (HP:0002518)1.79455580
160Primary atrial arrhythmia (HP:0001692)1.79208960
161Growth hormone deficiency (HP:0000824)1.79078175
162Furrowed tongue (HP:0000221)1.78960766
163Agitation (HP:0000713)1.77498812
164Abnormality of the aortic arch (HP:0012303)1.77393634
165Achilles tendon contracture (HP:0001771)1.76818425
166Micropenis (HP:0000054)1.76207332
167Narrow forehead (HP:0000341)1.75087314
168Progressive microcephaly (HP:0000253)1.74069788
169Septate vagina (HP:0001153)1.73273002
170Abnormality of the labia (HP:0000058)1.68662080
171Dental crowding (HP:0000678)1.66799836
172Male pseudohermaphroditism (HP:0000037)1.66599916
173Infertility (HP:0000789)1.65139597
174Congenital hepatic fibrosis (HP:0002612)1.64572183
175Aganglionic megacolon (HP:0002251)1.63434375
176Personality changes (HP:0000751)1.63059744
177Unsteady gait (HP:0002317)1.61240662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.23111864
2EPHA44.22467146
3NTRK34.12090829
4DAPK23.25118953
5MARK12.79781940
6PRKD32.77874121
7PAK62.62750594
8MINK12.62435332
9MAP3K42.51845556
10KSR22.39591172
11CAMKK12.27423896
12MAP2K72.17799404
13DAPK12.06196414
14CDK191.94547622
15CDC71.77080937
16NTRK21.76659793
17CAMK1D1.75960424
18MAP3K121.74086052
19KSR11.70231528
20DYRK21.68812013
21PRPF4B1.63999373
22ARAF1.63568350
23MAP2K41.58066019
24CDK51.54569589
25NTRK11.53123258
26PLK21.52894431
27EEF2K1.50307795
28STK381.50065236
29CAMKK21.47355607
30RIPK41.39112230
31GRK51.37061484
32EPHA31.36191592
33TAOK11.36170496
34BRD41.33739232
35CAMK1G1.31089859
36TYRO31.27805191
37CAMK11.26142913
38LATS21.24502600
39TNIK1.24460265
40CASK1.24183695
41PRKCG1.23301094
42MAP3K131.23233260
43WNK41.22390738
44PHKG21.21788779
45PHKG11.21788779
46SIK21.13825929
47MAPK131.13243388
48RAF11.07616424
49LMTK21.06566574
50PINK11.01631471
51MAP3K21.01337699
52STK111.00861015
53STK391.00631232
54DYRK31.00601296
55ALK0.99383656
56UHMK10.98052744
57PRKAA10.97405845
58PRKCI0.97253349
59CDK180.94363236
60CDK150.93790195
61CAMK2A0.92263899
62PTK2B0.89118369
63PDK10.88741132
64FES0.87383602
65PAK30.83361591
66CDK140.83289353
67CDK11A0.82836541
68EPHB20.82791432
69NEK10.81939541
70PRKCQ0.81779163
71PRKCH0.80638715
72LRRK20.79494773
73PDPK10.79190736
74RIPK10.79118851
75DAPK30.77659359
76SCYL20.76933498
77RET0.76752574
78MARK20.75309004
79DMPK0.75110029
80PRKG20.75108046
81ABL20.74539257
82CCNB10.71723776
83CAMK2B0.69391608
84OXSR10.68992535
85PRKD10.67956193
86MAP3K70.67913675
87CAMK40.67360656
88BRSK10.66931410
89MAP3K10.65274469
90SGK2230.63082480
91SGK4940.63082480
92TRIB30.60612360
93SIK10.58579777
94SGK10.58208650
95RPS6KL10.57014597
96RPS6KC10.57014597
97DYRK1A0.55952833
98BRAF0.55852911
99RPS6KA10.55236279
100CSNK1D0.54597650
101BMPR20.53671121
102SGK30.53368827
103RPS6KA60.52828480
104ILK0.52546708
105CSNK1G20.52064689
106CDC42BPA0.51786086
107TLK10.49212304
108PNCK0.48287768
109ERBB20.48244364
110SGK20.47519154
111PKN10.47021544
112MTOR0.45839576
113DYRK1B0.45357399
114RPS6KA30.44813948
115DDR20.42821060
116CAMK2D0.42233762
117MAPK120.40472250
118PRKCZ0.39736694
119ROCK20.38874921
120MOS0.38651216
121MAP2K10.38254990
122CAMK2G0.37948662
123MAP2K60.37083931
124AKT20.36328847
125CSNK1E0.36292261
126NME10.35829064
127PRKCD0.34859406
128FYN0.34792511
129PRKCE0.33812542
130MUSK0.33437885
131PRKACB0.33408759
132MAPK80.32785592
133RPS6KA20.30269508
134PRKD20.29902748
135MAPK100.29702366
136FER0.28137389
137PRKACA0.27156029
138IRAK10.26753416
139PKN20.26220640
140MAP3K60.25547443
141MAPKAPK50.25488570
142CSNK1A10.24581125

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.65451352
2Nicotine addiction_Homo sapiens_hsa050333.49274482
3DNA replication_Homo sapiens_hsa030303.33653809
4Synaptic vesicle cycle_Homo sapiens_hsa047213.32835246
5Steroid biosynthesis_Homo sapiens_hsa001003.16715016
6Long-term potentiation_Homo sapiens_hsa047202.90338830
7Circadian entrainment_Homo sapiens_hsa047132.81582862
8Glutamatergic synapse_Homo sapiens_hsa047242.66436068
9Olfactory transduction_Homo sapiens_hsa047402.58646354
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58269813
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.42477781
12Amphetamine addiction_Homo sapiens_hsa050312.41943118
13GABAergic synapse_Homo sapiens_hsa047272.37726946
14Salivary secretion_Homo sapiens_hsa049702.29223763
15Morphine addiction_Homo sapiens_hsa050322.25069590
16Insulin secretion_Homo sapiens_hsa049112.12192188
17Gastric acid secretion_Homo sapiens_hsa049712.05010917
18Dopaminergic synapse_Homo sapiens_hsa047281.99362257
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.99115646
20Cholinergic synapse_Homo sapiens_hsa047251.91942701
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.91892808
22Oxytocin signaling pathway_Homo sapiens_hsa049211.79857347
23Long-term depression_Homo sapiens_hsa047301.67256640
24Calcium signaling pathway_Homo sapiens_hsa040201.64236958
25Fatty acid biosynthesis_Homo sapiens_hsa000611.59756927
26GnRH signaling pathway_Homo sapiens_hsa049121.58394597
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55515775
28Arginine and proline metabolism_Homo sapiens_hsa003301.53061875
29Taste transduction_Homo sapiens_hsa047421.51317990
30Renin secretion_Homo sapiens_hsa049241.42675078
31Serotonergic synapse_Homo sapiens_hsa047261.35555212
32Pyrimidine metabolism_Homo sapiens_hsa002401.35049695
33Glioma_Homo sapiens_hsa052141.33524509
34Gap junction_Homo sapiens_hsa045401.31991770
35cAMP signaling pathway_Homo sapiens_hsa040241.31821959
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30378941
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29878989
38Cardiac muscle contraction_Homo sapiens_hsa042601.29796634
39Fanconi anemia pathway_Homo sapiens_hsa034601.27311661
40Type II diabetes mellitus_Homo sapiens_hsa049301.26655211
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26602954
42Estrogen signaling pathway_Homo sapiens_hsa049151.26272105
43Homologous recombination_Homo sapiens_hsa034401.23461350
44AMPK signaling pathway_Homo sapiens_hsa041521.22721313
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20374068
46Cocaine addiction_Homo sapiens_hsa050301.19704437
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18897483
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14758519
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12339543
50Collecting duct acid secretion_Homo sapiens_hsa049661.10567966
51Nitrogen metabolism_Homo sapiens_hsa009101.09427528
52ErbB signaling pathway_Homo sapiens_hsa040121.08074150
53Dilated cardiomyopathy_Homo sapiens_hsa054141.06682035
54Melanogenesis_Homo sapiens_hsa049161.02957483
55Axon guidance_Homo sapiens_hsa043601.02435104
56Oocyte meiosis_Homo sapiens_hsa041140.99856002
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99775256
58One carbon pool by folate_Homo sapiens_hsa006700.96359906
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.95681529
60Pancreatic secretion_Homo sapiens_hsa049720.94556447
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91119040
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.90359455
63VEGF signaling pathway_Homo sapiens_hsa043700.89808232
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86923800
65Butanoate metabolism_Homo sapiens_hsa006500.84895150
66Phototransduction_Homo sapiens_hsa047440.83577591
67Dorso-ventral axis formation_Homo sapiens_hsa043200.82801585
68Hedgehog signaling pathway_Homo sapiens_hsa043400.79558962
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79283869
70Regulation of autophagy_Homo sapiens_hsa041400.77353486
71Choline metabolism in cancer_Homo sapiens_hsa052310.76276161
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76163907
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.75665536
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75634178
75Thyroid hormone synthesis_Homo sapiens_hsa049180.75528982
76Basal cell carcinoma_Homo sapiens_hsa052170.73591629
77ABC transporters_Homo sapiens_hsa020100.71108077
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70900824
79MAPK signaling pathway_Homo sapiens_hsa040100.70595361
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69354024
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68858865
82Vibrio cholerae infection_Homo sapiens_hsa051100.66238922
83mTOR signaling pathway_Homo sapiens_hsa041500.64897831
84Glucagon signaling pathway_Homo sapiens_hsa049220.64123834
85RNA polymerase_Homo sapiens_hsa030200.64027643
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63149685
87Purine metabolism_Homo sapiens_hsa002300.63127511
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58859169
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58589199
90Circadian rhythm_Homo sapiens_hsa047100.57185267
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.55908192
92Non-small cell lung cancer_Homo sapiens_hsa052230.54797450
93Endocytosis_Homo sapiens_hsa041440.54411997
94Rap1 signaling pathway_Homo sapiens_hsa040150.54309353
95Ras signaling pathway_Homo sapiens_hsa040140.53944591
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53686533
97Endometrial cancer_Homo sapiens_hsa052130.51966491
98Bile secretion_Homo sapiens_hsa049760.50632396
99Parkinsons disease_Homo sapiens_hsa050120.50152830
100Oxidative phosphorylation_Homo sapiens_hsa001900.49996808
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49639089
102Ribosome_Homo sapiens_hsa030100.49017658
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48733037
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48724505
105Insulin signaling pathway_Homo sapiens_hsa049100.48595217
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48306724
107Inositol phosphate metabolism_Homo sapiens_hsa005620.47942818
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46185242
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.44842654
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42360723
111Notch signaling pathway_Homo sapiens_hsa043300.40960853
112Renal cell carcinoma_Homo sapiens_hsa052110.40474304
113Hippo signaling pathway_Homo sapiens_hsa043900.39904267
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38486388
115Fatty acid metabolism_Homo sapiens_hsa012120.38445116
116Biosynthesis of amino acids_Homo sapiens_hsa012300.35570589
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.35496034
118Wnt signaling pathway_Homo sapiens_hsa043100.34100629
119Prion diseases_Homo sapiens_hsa050200.33969313
120Ovarian steroidogenesis_Homo sapiens_hsa049130.33015958
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32255358
122Huntingtons disease_Homo sapiens_hsa050160.31293083
123Chemokine signaling pathway_Homo sapiens_hsa040620.29979977
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29640675
125beta-Alanine metabolism_Homo sapiens_hsa004100.29268141
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29045183
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28947958
128Alcoholism_Homo sapiens_hsa050340.27346282
129HIF-1 signaling pathway_Homo sapiens_hsa040660.26485264
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25391698
131Platelet activation_Homo sapiens_hsa046110.25071182
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24902769
133Vitamin B6 metabolism_Homo sapiens_hsa007500.24665614
134Alzheimers disease_Homo sapiens_hsa050100.23930783
135African trypanosomiasis_Homo sapiens_hsa051430.22182846

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