RTP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* protein insertion into membrane (GO:0051205)7.87620275
2regulation of female gonad development (GO:2000194)7.65702646
3regulation of chromatin binding (GO:0035561)6.70481616
4adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.12063467
5axonemal dynein complex assembly (GO:0070286)6.04252615
6intraciliary transport (GO:0042073)5.97587243
7protein polyglutamylation (GO:0018095)5.88662160
8regulation of cilium movement (GO:0003352)5.79446080
9axoneme assembly (GO:0035082)5.65482602
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.34034093
11antibacterial humoral response (GO:0019731)5.18409595
12cilium morphogenesis (GO:0060271)5.10827264
13innate immune response in mucosa (GO:0002227)5.03002532
14cilium movement (GO:0003341)4.83850078
15auditory receptor cell differentiation (GO:0042491)4.80702518
16antimicrobial humoral response (GO:0019730)4.77704459
17olfactory bulb development (GO:0021772)4.68084096
18adipose tissue development (GO:0060612)4.65310093
19phosphorelay signal transduction system (GO:0000160)4.59584004
20microtubule severing (GO:0051013)4.39606221
21photoreceptor cell maintenance (GO:0045494)4.29190076
22detection of calcium ion (GO:0005513)4.23699442
23negative regulation of cytosolic calcium ion concentration (GO:0051481)4.20512984
24activation of protein kinase A activity (GO:0034199)4.09286027
25mucosal immune response (GO:0002385)4.07218245
26natural killer cell mediated immunity (GO:0002228)4.02626116
27natural killer cell mediated cytotoxicity (GO:0042267)4.02626116
28epithelial cilium movement (GO:0003351)3.92753172
29dopamine receptor signaling pathway (GO:0007212)3.90813458
30regulation of cell communication by electrical coupling (GO:0010649)3.90008516
31neuron cell-cell adhesion (GO:0007158)3.88855130
32organ or tissue specific immune response (GO:0002251)3.85481390
33regulation of sodium ion transmembrane transporter activity (GO:2000649)3.84796951
34negative regulation of complement activation (GO:0045916)3.76740069
35regulation of heart rate by cardiac conduction (GO:0086091)3.76494917
36behavioral response to cocaine (GO:0048148)3.75281518
37cellular copper ion homeostasis (GO:0006878)3.69248091
38negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.68255428
39axonal fasciculation (GO:0007413)3.63425657
40left/right axis specification (GO:0070986)3.60224279
41cellular response to glucagon stimulus (GO:0071377)3.58662912
42microtubule bundle formation (GO:0001578)3.55684518
43negative regulation of transcription regulatory region DNA binding (GO:2000678)3.53080722
44cAMP biosynthetic process (GO:0006171)3.51934180
45positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.45629886
46response to caffeine (GO:0031000)3.43136847
47atrial cardiac muscle cell action potential (GO:0086014)3.43054456
48mating behavior (GO:0007617)3.39269742
49protein heterotetramerization (GO:0051290)3.39243588
50regulation of sodium ion transmembrane transport (GO:1902305)3.38364980
51glycogen catabolic process (GO:0005980)3.35100657
52membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.32037681
53regulation of microtubule-based movement (GO:0060632)3.31143461
54facial nerve structural organization (GO:0021612)3.25124459
55ventricular system development (GO:0021591)3.22094142
56cellular response to electrical stimulus (GO:0071257)3.20761579
57negative regulation of protein activation cascade (GO:2000258)3.17327900
58centriole replication (GO:0007099)3.14401824
59glucan catabolic process (GO:0009251)3.12510598
60magnesium ion transport (GO:0015693)3.12370893
61negative regulation of astrocyte differentiation (GO:0048712)3.08945789
62cardiac conduction (GO:0061337)3.08672605
63potassium ion transmembrane transport (GO:0071805)3.06469051
64cellular potassium ion transport (GO:0071804)3.06469051
65negative regulation of sodium ion transport (GO:0010766)3.05380303
66response to amphetamine (GO:0001975)3.01913544
67negative regulation of microtubule polymerization (GO:0031115)3.00846738
68sensory perception of smell (GO:0007608)23.7218252
69connective tissue development (GO:0061448)2.99036301
70glutamate secretion (GO:0014047)2.98509117
71sensory perception of taste (GO:0050909)2.98377753
72cilium assembly (GO:0042384)2.94257244
73membrane repolarization during action potential (GO:0086011)2.93090799
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92620770
75neurogenesis (GO:0022008)2.90455538
76nucleoside diphosphate phosphorylation (GO:0006165)2.87703629
77melanosome transport (GO:0032402)2.87354752
78relaxation of cardiac muscle (GO:0055119)2.86946304
79hair cell differentiation (GO:0035315)2.84665467
80negative regulation of humoral immune response (GO:0002921)2.83128764
81response to glucagon (GO:0033762)2.82198415
82ovulation cycle (GO:0042698)2.80069380
83ganglion development (GO:0061548)2.79082798
84cilium organization (GO:0044782)2.77434642
85establishment of melanosome localization (GO:0032401)2.75827576
86potassium ion transport (GO:0006813)2.75294727
87cellular polysaccharide catabolic process (GO:0044247)2.74797181
88histone H2B ubiquitination (GO:0033523)2.73594253
89potassium ion homeostasis (GO:0055075)2.71096190
90pigment granule transport (GO:0051904)2.70233261
91melanosome localization (GO:0032400)2.70225469
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69480819
93regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.68465282
94brain morphogenesis (GO:0048854)2.68127589
95regulation of sodium ion transport (GO:0002028)2.67881230
96copper ion homeostasis (GO:0055070)2.65508367
97regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.65485917
98response to gravity (GO:0009629)2.62139014
99sensory perception of chemical stimulus (GO:0007606)13.8685375
100protein localization to cilium (GO:0061512)10.5687489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.72105814
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.42785267
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.41196471
4ZNF263_19887448_ChIP-Seq_K562_Human3.25638108
5GBX2_23144817_ChIP-Seq_PC3_Human3.07134873
6DROSHA_22980978_ChIP-Seq_HELA_Human2.85635372
7BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.75862000
8GATA1_26923725_Chip-Seq_HPCs_Mouse2.14724003
9ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.05200471
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03336111
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03336111
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02217763
13TAF15_26573619_Chip-Seq_HEK293_Human1.97239602
14BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90552005
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88131048
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.86969822
17LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76720543
18AHR_22903824_ChIP-Seq_MCF-7_Human1.72651182
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71981156
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71962565
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68295120
22GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.67733886
23RNF2_27304074_Chip-Seq_NSC_Mouse1.64297048
24REST_21632747_ChIP-Seq_MESCs_Mouse1.60045380
25NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53250992
26CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52307312
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51330952
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51330952
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50132040
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46191436
31KDM2B_26808549_Chip-Seq_K562_Human1.45160883
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44984648
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44735810
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44650782
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.43987421
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40240832
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39324557
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34392285
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32630668
40OCT4_20526341_ChIP-Seq_ESCs_Human1.32515756
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29343576
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.28243654
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28199455
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28009251
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27956607
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27650785
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25360597
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.25014223
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.21876338
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.20318686
51SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18913729
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16953837
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16433255
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15423759
55SMAD4_21799915_ChIP-Seq_A2780_Human1.14998294
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14663703
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.13016138
58* RING1B_27294783_Chip-Seq_ESCs_Mouse1.12763674
59P300_19829295_ChIP-Seq_ESCs_Human1.12443787
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08130320
61* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07956866
62* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07619986
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.07450735
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06034945
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.04468908
66MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01239990
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01078644
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00106399
69CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99659245
70GATA3_27048872_Chip-Seq_THYMUS_Human0.98692068
71WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98231765
72PRDM14_20953172_ChIP-Seq_ESCs_Human0.97634685
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94088088
74PIAS1_25552417_ChIP-Seq_VCAP_Human0.92260084
75SMAD4_21741376_ChIP-Seq_HESCs_Human0.92095128
76SMAD3_21741376_ChIP-Seq_EPCs_Human0.92069134
77STAT1_20625510_ChIP-Seq_HELA_Human0.91778644
78NCOR_22424771_ChIP-Seq_293T_Human0.91373503
79RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90646302
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90098025
81TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88566607
82TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88157916
83REST_18959480_ChIP-ChIP_MESCs_Mouse0.87013731
84SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85910840
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85288116
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85263673
87CTCF_20526341_ChIP-Seq_ESCs_Human0.84857422
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84474938
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.84221083
90KLF5_25053715_ChIP-Seq_YYC3_Human0.84192027
91CBX2_27304074_Chip-Seq_ESCs_Mouse0.84135717
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84082721
93NANOG_20526341_ChIP-Seq_ESCs_Human0.83739101
94ERA_21632823_ChIP-Seq_H3396_Human0.83313484
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83126941
96PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82744282
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82680702
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82596105
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82053018
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.80302050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium4.86440212
2MP0005394_taste/olfaction_phenotype4.51208567
3MP0005499_abnormal_olfactory_system4.51208567
4MP0005645_abnormal_hypothalamus_physiol3.09753458
5MP0003806_abnormal_nucleotide_metabolis3.04287496
6MP0001485_abnormal_pinna_reflex2.78067600
7MP0002184_abnormal_innervation2.44715233
8MP0003878_abnormal_ear_physiology2.21403907
9MP0005377_hearing/vestibular/ear_phenot2.21403907
10MP0001984_abnormal_olfaction15.0803497
11MP0002160_abnormal_reproductive_system1.98445134
12MP0001542_abnormal_bone_strength1.78500002
13MP0005367_renal/urinary_system_phenotyp1.55678149
14MP0000516_abnormal_urinary_system1.55678149
15MP0002752_abnormal_somatic_nervous1.49633976
16MP0002928_abnormal_bile_duct1.47857643
17MP0001486_abnormal_startle_reflex1.45361629
18MP0002822_catalepsy1.44206621
19MP0002557_abnormal_social/conspecific_i1.31425040
20MP0002653_abnormal_ependyma_morphology1.28442512
21MP0002734_abnormal_mechanical_nocicepti1.25232124
22MP0005084_abnormal_gallbladder_morpholo1.23394592
23MP0002233_abnormal_nose_morphology1.23284150
24MP0002272_abnormal_nervous_system1.22433780
25MP0001293_anophthalmia1.21957765
26MP0000778_abnormal_nervous_system1.16142714
27MP0004133_heterotaxia1.12631888
28MP0002882_abnormal_neuron_morphology1.12455353
29MP0005410_abnormal_fertilization1.12190615
30MP0010234_abnormal_vibrissa_follicle1.08776944
31MP0000372_irregular_coat_pigmentation1.06133666
32MP0003252_abnormal_bile_duct1.05137346
33MP0005389_reproductive_system_phenotype1.03011819
34MP0003635_abnormal_synaptic_transmissio1.01665309
35MP0004270_analgesia0.99717955
36MP0005646_abnormal_pituitary_gland0.97621162
37MP0005551_abnormal_eye_electrophysiolog0.97399300
38MP0008875_abnormal_xenobiotic_pharmacok0.97295178
39MP0004742_abnormal_vestibular_system0.93726435
40MP0006276_abnormal_autonomic_nervous0.84990537
41MP0002152_abnormal_brain_morphology0.82459391
42MP0004811_abnormal_neuron_physiology0.81930937
43MP0009333_abnormal_splenocyte_physiolog0.79059553
44MP0002063_abnormal_learning/memory/cond0.78538013
45MP0003880_abnormal_central_pattern0.77484395
46MP0002102_abnormal_ear_morphology0.75773015
47MP0002229_neurodegeneration0.74008763
48MP0005187_abnormal_penis_morphology0.73913109
49MP0002877_abnormal_melanocyte_morpholog0.72441576
50MP0000003_abnormal_adipose_tissue0.68166866
51MP0001963_abnormal_hearing_physiology0.68065805
52MP0002572_abnormal_emotion/affect_behav0.67563194
53MP0000026_abnormal_inner_ear0.65684866
54MP0005423_abnormal_somatic_nervous0.62909854
55MP0002751_abnormal_autonomic_nervous0.60900273
56MP0000631_abnormal_neuroendocrine_gland0.60716705
57MP0002909_abnormal_adrenal_gland0.60268363
58MP0003879_abnormal_hair_cell0.59705223
59MP0004859_abnormal_synaptic_plasticity0.59396550
60MP0003634_abnormal_glial_cell0.58828921
61MP0005195_abnormal_posterior_eye0.56642261
62MP0003861_abnormal_nervous_system0.56443065
63MP0002092_abnormal_eye_morphology0.55944618
64MP0001188_hyperpigmentation0.54918795
65MP0002896_abnormal_bone_mineralization0.54824272
66MP0002067_abnormal_sensory_capabilities0.54384430
67MP0005584_abnormal_enzyme/coenzyme_acti0.54319895
68MP0001970_abnormal_pain_threshold0.50586410
69MP0000538_abnormal_urinary_bladder0.47608830
70MP0009765_abnormal_xenobiotic_induced0.47385226
71MP0002064_seizures0.46659493
72MP0003693_abnormal_embryo_hatching0.44835828
73MP0000049_abnormal_middle_ear0.44603260
74MP0002132_abnormal_respiratory_system0.43656881
75MP0009745_abnormal_behavioral_response0.43318728
76MP0004858_abnormal_nervous_system0.40227189
77MP0003942_abnormal_urinary_system0.40118022
78MP0008874_decreased_physiological_sensi0.39840033
79MP0006036_abnormal_mitochondrial_physio0.36930199
80MP0006082_CNS_inflammation0.35582127
81MP0005365_abnormal_bile_salt0.33868355
82MP0010770_preweaning_lethality0.33699225
83MP0002082_postnatal_lethality0.33699225
84MP0004145_abnormal_muscle_electrophysio0.33360147
85MP0002066_abnormal_motor_capabilities/c0.32159171
86MP0000955_abnormal_spinal_cord0.31866307
87MP0005165_increased_susceptibility_to0.30711864
88MP0003633_abnormal_nervous_system0.30596794
89MP0004484_altered_response_of0.29665266
90MP0010769_abnormal_survival0.28796690
91MP0002081_perinatal_lethality0.28079165
92MP0005220_abnormal_exocrine_pancreas0.26490733
93MP0010768_mortality/aging0.26337485
94MP0003195_calcinosis0.25878587
95MP0003938_abnormal_ear_development0.25695065
96MP0005174_abnormal_tail_pigmentation0.25352323
97MP0002210_abnormal_sex_determination0.25339882
98MP0001119_abnormal_female_reproductive0.25239238
99MP0003075_altered_response_to0.24940470
100MP0003936_abnormal_reproductive_system0.24848918

Predicted human phenotypes

RankGene SetZ-score
1Retinal dysplasia (HP:0007973)7.15789579
2Abnormal respiratory motile cilium physiology (HP:0012261)7.05832284
3Rhinitis (HP:0012384)6.52275857
4Chronic bronchitis (HP:0004469)6.22650094
5Abnormality of macular pigmentation (HP:0008002)5.74590779
6Abnormal ciliary motility (HP:0012262)5.09349208
7Limb dystonia (HP:0002451)5.08326792
8Molar tooth sign on MRI (HP:0002419)5.06172425
9Abnormality of midbrain morphology (HP:0002418)5.06172425
10Abnormal respiratory motile cilium morphology (HP:0005938)4.95078606
11Abnormal respiratory epithelium morphology (HP:0012253)4.95078606
12Bifid tongue (HP:0010297)4.58067426
13Palpitations (HP:0001962)4.42880767
14Bony spicule pigmentary retinopathy (HP:0007737)4.29659476
15Dysphonia (HP:0001618)4.04320490
16Chronic hepatic failure (HP:0100626)3.93955586
17Short nail (HP:0001799)3.88427752
18Hypochromic microcytic anemia (HP:0004840)3.87392024
19Atonic seizures (HP:0010819)3.59579934
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.56251211
21Absent/shortened dynein arms (HP:0200106)3.56251211
22Abnormality of dentin (HP:0010299)3.51772911
23Anosmia (HP:0000458)3.49867707
24Pancreatic fibrosis (HP:0100732)3.49327833
25Gait imbalance (HP:0002141)3.41972299
26Hypothermia (HP:0002045)3.39502806
27Bronchiectasis (HP:0002110)3.33211991
28Congenital primary aphakia (HP:0007707)3.32346983
29Nephronophthisis (HP:0000090)3.30917220
30Postaxial hand polydactyly (HP:0001162)3.17651541
31Nephrogenic diabetes insipidus (HP:0009806)3.16641458
32Occipital encephalocele (HP:0002085)3.15584194
33Medial flaring of the eyebrow (HP:0010747)3.04069049
34Syncope (HP:0001279)3.02926472
35Abolished electroretinogram (ERG) (HP:0000550)3.00580844
36True hermaphroditism (HP:0010459)2.88758089
37Poikilocytosis (HP:0004447)2.83824724
38Febrile seizures (HP:0002373)2.83393323
39Tubulointerstitial nephritis (HP:0001970)2.82900717
40Abnormality of the renal medulla (HP:0100957)2.69815441
41Pancreatic cysts (HP:0001737)2.68833040
42Torticollis (HP:0000473)2.67100040
43Abnormality of sodium homeostasis (HP:0010931)2.62598962
44Central scotoma (HP:0000603)2.60167639
45Cystic liver disease (HP:0006706)2.59622366
46Median cleft lip (HP:0000161)2.57750081
47Insidious onset (HP:0003587)2.53960168
48Termporal pattern (HP:0011008)2.53960168
49Oculomotor apraxia (HP:0000657)2.53352081
50Vaginal atresia (HP:0000148)2.52481352
51Prolonged QT interval (HP:0001657)2.49575637
52Poor coordination (HP:0002370)2.44936066
53Abnormality of permanent molar morphology (HP:0011071)2.43969312
54Abnormality of the dental root (HP:0006486)2.43969312
55Taurodontia (HP:0000679)2.43969312
56Genital tract atresia (HP:0001827)2.41577834
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35782375
58Craniofacial dystonia (HP:0012179)2.31229094
59Abnormality of molar (HP:0011077)2.31221858
60Abnormality of molar morphology (HP:0011070)2.31221858
61Aplasia/Hypoplasia of the lens (HP:0008063)2.28251851
62Constricted visual fields (HP:0001133)2.27634337
63Absence seizures (HP:0002121)2.27063372
64Bronchitis (HP:0012387)2.25757311
65Chronic sinusitis (HP:0011109)2.23216885
66Bile duct proliferation (HP:0001408)2.21942940
67Abnormal biliary tract physiology (HP:0012439)2.21942940
68Sudden death (HP:0001699)2.15092578
69Abnormality of the dental pulp (HP:0006479)2.11134970
70Congenital hepatic fibrosis (HP:0002612)2.10039316
71Restlessness (HP:0000711)2.09776271
72Retinitis pigmentosa (HP:0000510)2.09511641
73Focal dystonia (HP:0004373)2.09466638
74Postaxial foot polydactyly (HP:0001830)2.08535207
75Recurrent otitis media (HP:0000403)2.07361044
76Complete atrioventricular canal defect (HP:0001674)2.03872222
77Myokymia (HP:0002411)2.03639786
78Agitation (HP:0000713)2.02986285
79Xerostomia (HP:0000217)2.02892654
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.3720760
81Nasal polyposis (HP:0100582)1.97134333
82Furrowed tongue (HP:0000221)1.94441543
83Erectile abnormalities (HP:0100639)1.93598755
84Abnormality of the diencephalon (HP:0010662)1.87812218
85Sclerocornea (HP:0000647)1.87437408
86Hyperglycinemia (HP:0002154)1.85040564
87Diminished motivation (HP:0000745)1.84101992
88Bradycardia (HP:0001662)1.83740571
89Pulmonary artery stenosis (HP:0004415)1.79869274
90Abnormal rod and cone electroretinograms (HP:0008323)1.76927377
91Abnormal EKG (HP:0003115)1.76494651
92Renal hypoplasia (HP:0000089)1.76470493
93Aplasia/Hypoplasia of the tongue (HP:0010295)1.72516537
94Dialeptic seizures (HP:0011146)1.72504783
95Narrow forehead (HP:0000341)1.71558839
96Aganglionic megacolon (HP:0002251)1.71087116
97Facial cleft (HP:0002006)1.70084657
98Decreased testicular size (HP:0008734)1.67581175
99Apathy (HP:0000741)1.67321332
100Recurrent sinusitis (HP:0011108)1.67090080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG15.57385160
2PHKG25.57385160
3MAPK155.42334364
4ERBB33.79197302
5PAK33.54478254
6ARAF3.44169032
7MAPKAPK32.76886792
8CAMK2D2.48484040
9EEF2K2.38556065
10CAMK2B2.20657519
11STK38L1.96885239
12STK241.94302466
13CAMK2G1.83976626
14DAPK21.81785573
15NUAK11.81247447
16STK161.75263860
17SRPK11.70491008
18ICK1.70105950
19PIM21.68738570
20SIK21.56745659
21CSNK1A1L1.52500008
22RIPK11.28395246
23ILK1.22358953
24CSNK1G31.20162449
25HIPK21.18913480
26CSNK1G21.13911166
27DAPK11.13837597
28PRKCG1.10182855
29STK391.07754755
30CSNK1G11.05544202
31FRK1.04817729
32RPS6KA21.03486412
33BRAF1.02922130
34STK380.97597111
35DYRK30.93369375
36DYRK1A0.90116508
37MAPK130.89767791
38MAP3K20.85133659
39CAMK1G0.82538079
40TNK20.73741346
41DYRK1B0.72826641
42MAP3K100.72407321
43CAMKK20.70120365
44MAP2K70.69605553
45TRPM70.67826205
46MARK10.67391597
47GRK50.66939826
48GRK60.66729930
49MAP3K40.66554763
50TTK0.65527097
51CAMK2A0.62749278
52MINK10.60214698
53STK110.58593907
54AKT30.56239889
55PLK20.51281434
56CAMK1D0.48364299
57AKT20.48201831
58TYRO30.47089831
59PINK10.45710886
60MAPKAPK20.45377817
61MAPKAPK50.45298276
62TGFBR20.44714559
63AURKA0.40249298
64MARK20.38091263
65CASK0.37723611
66WNK40.37384858
67CDK50.36950094
68CDK90.36282102
69NTRK20.35831760
70SGK2230.35499018
71SGK4940.35499018
72PRKCQ0.35218612
73TRIB30.34668561
74NLK0.32994177
75RAF10.30787348
76MAP3K30.30600341
77MAP2K40.30445583
78PRKCI0.30338163
79PRKAA20.28491519
80FYN0.28204643
81PNCK0.27901086
82ROCK20.25812045
83PRKCZ0.25186939
84PRKD20.25098529
85PKN10.24674154
86DAPK30.24586455
87PRKD10.23837602
88PRKAA10.23477729
89EGFR0.22446573
90TNIK0.21953081
91SGK20.20490870
92BMPR20.20285689
93PTK2B0.20265281
94INSR0.19866426
95CAMK40.19432642
96TXK0.18214590
97PRKACG0.18104271
98PRKACA0.17828488
99PRKCA0.17209270
100MAPK100.17206703

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.09924337
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.86707456
3Taste transduction_Homo sapiens_hsa047422.05645191
4Olfactory transduction_Homo sapiens_hsa0474012.3139669
5Circadian entrainment_Homo sapiens_hsa047131.84035001
6Morphine addiction_Homo sapiens_hsa050321.71002752
7Dopaminergic synapse_Homo sapiens_hsa047281.51856422
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49322352
9cAMP signaling pathway_Homo sapiens_hsa040241.46428939
10Insulin secretion_Homo sapiens_hsa049111.44272244
11Histidine metabolism_Homo sapiens_hsa003401.40950459
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40865308
13Gastric acid secretion_Homo sapiens_hsa049711.40655703
14Vibrio cholerae infection_Homo sapiens_hsa051101.35613589
15GABAergic synapse_Homo sapiens_hsa047271.32715938
16Glutamatergic synapse_Homo sapiens_hsa047241.29180930
17Ovarian steroidogenesis_Homo sapiens_hsa049131.26052885
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25694172
19Salivary secretion_Homo sapiens_hsa049701.24405285
20Cholinergic synapse_Homo sapiens_hsa047251.24376668
21beta-Alanine metabolism_Homo sapiens_hsa004101.24082309
22Alcoholism_Homo sapiens_hsa050341.16904215
23Amphetamine addiction_Homo sapiens_hsa050311.10057045
24Synaptic vesicle cycle_Homo sapiens_hsa047211.08748551
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06826929
26Bile secretion_Homo sapiens_hsa049761.06305099
27Fatty acid biosynthesis_Homo sapiens_hsa000611.03236257
28cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00879783
29Parkinsons disease_Homo sapiens_hsa050120.99867604
30Thyroid hormone synthesis_Homo sapiens_hsa049180.96904187
31Collecting duct acid secretion_Homo sapiens_hsa049660.96597199
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95710818
33Sphingolipid metabolism_Homo sapiens_hsa006000.93798110
34Calcium signaling pathway_Homo sapiens_hsa040200.93266294
35GnRH signaling pathway_Homo sapiens_hsa049120.87104244
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82894209
37Renin secretion_Homo sapiens_hsa049240.76056297
38Estrogen signaling pathway_Homo sapiens_hsa049150.74814646
39Glucagon signaling pathway_Homo sapiens_hsa049220.74554752
40Melanogenesis_Homo sapiens_hsa049160.73378436
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71174699
42Alzheimers disease_Homo sapiens_hsa050100.69386067
43Long-term potentiation_Homo sapiens_hsa047200.68667983
44Oxidative phosphorylation_Homo sapiens_hsa001900.67345540
45ABC transporters_Homo sapiens_hsa020100.65399153
46Serotonergic synapse_Homo sapiens_hsa047260.64109852
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59566751
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58207255
49Systemic lupus erythematosus_Homo sapiens_hsa053220.57879469
50Oxytocin signaling pathway_Homo sapiens_hsa049210.56628306
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55600341
52N-Glycan biosynthesis_Homo sapiens_hsa005100.54607864
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54315789
54Purine metabolism_Homo sapiens_hsa002300.51858629
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51793086
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.49206717
57Cardiac muscle contraction_Homo sapiens_hsa042600.48841237
58Huntingtons disease_Homo sapiens_hsa050160.45543666
59Cocaine addiction_Homo sapiens_hsa050300.45304233
60Gap junction_Homo sapiens_hsa045400.44987066
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.44925186
62Sulfur metabolism_Homo sapiens_hsa009200.43287896
63Oocyte meiosis_Homo sapiens_hsa041140.43098870
64Axon guidance_Homo sapiens_hsa043600.41126999
65Other glycan degradation_Homo sapiens_hsa005110.40725026
66Sulfur relay system_Homo sapiens_hsa041220.40667880
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38221896
68Insulin signaling pathway_Homo sapiens_hsa049100.36451887
69Ras signaling pathway_Homo sapiens_hsa040140.36429767
70Pancreatic secretion_Homo sapiens_hsa049720.34975946
71Rap1 signaling pathway_Homo sapiens_hsa040150.34285816
72Dilated cardiomyopathy_Homo sapiens_hsa054140.33436864
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30222422
74Pyruvate metabolism_Homo sapiens_hsa006200.29091638
75Arachidonic acid metabolism_Homo sapiens_hsa005900.28927606
76Nicotine addiction_Homo sapiens_hsa050330.26046726
77Glioma_Homo sapiens_hsa052140.25728965
78Arginine and proline metabolism_Homo sapiens_hsa003300.24927141
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24194571
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.24033312
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23470047
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22701638
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22696902
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.20829956
85Chemokine signaling pathway_Homo sapiens_hsa040620.18838347
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17950413
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17719653
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17622240
89Fatty acid degradation_Homo sapiens_hsa000710.17374507
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16123496
91Peroxisome_Homo sapiens_hsa041460.15071677
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13357024
93Amoebiasis_Homo sapiens_hsa051460.13270377
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13125885
95Tuberculosis_Homo sapiens_hsa051520.12396896
96Propanoate metabolism_Homo sapiens_hsa006400.12368937
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.10630855
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.09514899
99Tight junction_Homo sapiens_hsa045300.08933521
100Notch signaling pathway_Homo sapiens_hsa043300.08764678

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