

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | L-phenylalanine catabolic process (GO:0006559) | 7.51511987 |
| 2 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 7.51511987 |
| 3 | epoxygenase P450 pathway (GO:0019373) | 7.23313958 |
| 4 | L-phenylalanine metabolic process (GO:0006558) | 7.19234093 |
| 5 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 7.19234093 |
| 6 | phenylpropanoid metabolic process (GO:0009698) | 7.05417022 |
| 7 | aromatic amino acid family catabolic process (GO:0009074) | 6.95343376 |
| 8 | oxidative demethylation (GO:0070989) | 6.56698705 |
| 9 | tryptophan catabolic process (GO:0006569) | 6.52896719 |
| 10 | indole-containing compound catabolic process (GO:0042436) | 6.52896719 |
| 11 | indolalkylamine catabolic process (GO:0046218) | 6.52896719 |
| 12 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 6.36404159 |
| 13 | omega-hydroxylase P450 pathway (GO:0097267) | 6.34877666 |
| 14 | exogenous drug catabolic process (GO:0042738) | 6.34763405 |
| 15 | kynurenine metabolic process (GO:0070189) | 6.27495397 |
| 16 | tryptophan metabolic process (GO:0006568) | 6.09038071 |
| 17 | bile acid biosynthetic process (GO:0006699) | 5.92405469 |
| 18 | drug metabolic process (GO:0017144) | 5.69085780 |
| 19 | high-density lipoprotein particle remodeling (GO:0034375) | 5.67443133 |
| 20 | glyoxylate metabolic process (GO:0046487) | 5.63770849 |
| 21 | negative regulation of fibrinolysis (GO:0051918) | 5.60017141 |
| 22 | urea metabolic process (GO:0019627) | 5.51644481 |
| 23 | urea cycle (GO:0000050) | 5.51644481 |
| 24 | regulation of fibrinolysis (GO:0051917) | 5.47853666 |
| 25 | uronic acid metabolic process (GO:0006063) | 5.46314171 |
| 26 | regulation of protein activation cascade (GO:2000257) | 5.42701709 |
| 27 | serine family amino acid catabolic process (GO:0009071) | 5.33717480 |
| 28 | peptidyl-glutamic acid carboxylation (GO:0017187) | 5.32912043 |
| 29 | protein carboxylation (GO:0018214) | 5.32912043 |
| 30 | alpha-linolenic acid metabolic process (GO:0036109) | 5.30124221 |
| 31 | complement activation, alternative pathway (GO:0006957) | 5.27872761 |
| 32 | alkaloid metabolic process (GO:0009820) | 5.25976061 |
| 33 | cysteine metabolic process (GO:0006534) | 5.14447229 |
| 34 | aromatic amino acid family metabolic process (GO:0009072) | 5.12319247 |
| 35 | sulfur amino acid catabolic process (GO:0000098) | 5.10596493 |
| 36 | nitrogen cycle metabolic process (GO:0071941) | 5.09168775 |
| 37 | bile acid metabolic process (GO:0008206) | 5.07452527 |
| 38 | regulation of complement activation (GO:0030449) | 5.06287912 |
| 39 | hormone catabolic process (GO:0042447) | 5.04728452 |
| 40 | regulation of plasminogen activation (GO:0010755) | 4.98643092 |
| 41 | regulation of triglyceride catabolic process (GO:0010896) | 4.97756845 |
| 42 | homocysteine metabolic process (GO:0050667) | 4.95385034 |
| 43 | reverse cholesterol transport (GO:0043691) | 4.94263225 |
| 44 | regulation of cholesterol esterification (GO:0010872) | 4.91101763 |
| 45 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.83774589 |
| 46 | macromolecular complex remodeling (GO:0034367) | 4.81763933 |
| 47 | plasma lipoprotein particle remodeling (GO:0034369) | 4.81763933 |
| 48 | protein-lipid complex remodeling (GO:0034368) | 4.81763933 |
| 49 | triglyceride homeostasis (GO:0070328) | 4.79591559 |
| 50 | acylglycerol homeostasis (GO:0055090) | 4.79591559 |
| 51 | negative regulation of blood coagulation (GO:0030195) | 4.76422960 |
| 52 | negative regulation of hemostasis (GO:1900047) | 4.76422960 |
| 53 | phospholipid efflux (GO:0033700) | 4.74809505 |
| 54 | tyrosine metabolic process (GO:0006570) | 4.72716918 |
| 55 | amine catabolic process (GO:0009310) | 4.72004608 |
| 56 | cellular biogenic amine catabolic process (GO:0042402) | 4.72004608 |
| 57 | alpha-amino acid catabolic process (GO:1901606) | 4.67154678 |
| 58 | indolalkylamine metabolic process (GO:0006586) | 4.64723399 |
| 59 | amino-acid betaine metabolic process (GO:0006577) | 4.61881127 |
| 60 | steroid catabolic process (GO:0006706) | 4.54303484 |
| 61 | glycine metabolic process (GO:0006544) | 4.54167625 |
| 62 | coenzyme catabolic process (GO:0009109) | 4.52707854 |
| 63 | negative regulation of sterol transport (GO:0032372) | 4.49836821 |
| 64 | negative regulation of cholesterol transport (GO:0032375) | 4.49836821 |
| 65 | imidazole-containing compound metabolic process (GO:0052803) | 4.49205721 |
| 66 | regulation of lipoprotein particle clearance (GO:0010984) | 4.44145717 |
| 67 | ethanol metabolic process (GO:0006067) | 4.44071787 |
| 68 | bile acid and bile salt transport (GO:0015721) | 4.43382547 |
| 69 | plasma lipoprotein particle clearance (GO:0034381) | 4.34867612 |
| 70 | negative regulation of wound healing (GO:0061045) | 4.34638541 |
| 71 | lysine catabolic process (GO:0006554) | 4.33443735 |
| 72 | lysine metabolic process (GO:0006553) | 4.33443735 |
| 73 | negative regulation of coagulation (GO:0050819) | 4.33137429 |
| 74 | cellular ketone body metabolic process (GO:0046950) | 4.31687545 |
| 75 | cellular amino acid catabolic process (GO:0009063) | 4.27000344 |
| 76 | cholesterol efflux (GO:0033344) | 4.26131208 |
| 77 | serine family amino acid metabolic process (GO:0009069) | 4.22139368 |
| 78 | negative regulation of protein activation cascade (GO:2000258) | 4.14408976 |
| 79 | benzene-containing compound metabolic process (GO:0042537) | 4.11068207 |
| 80 | proline metabolic process (GO:0006560) | 4.10464690 |
| 81 | glutamate metabolic process (GO:0006536) | 4.10453988 |
| 82 | positive regulation of triglyceride lipase activity (GO:0061365) | 4.08114885 |
| 83 | positive regulation of lipoprotein lipase activity (GO:0051006) | 4.08114885 |
| 84 | arginine metabolic process (GO:0006525) | 4.05126787 |
| 85 | regulation of humoral immune response (GO:0002920) | 4.03244622 |
| 86 | fibrinolysis (GO:0042730) | 4.01845332 |
| 87 | blood coagulation, intrinsic pathway (GO:0007597) | 4.00926351 |
| 88 | plasma lipoprotein particle assembly (GO:0034377) | 4.00313877 |
| 89 | cellular glucuronidation (GO:0052695) | 4.00188226 |
| 90 | serine family amino acid biosynthetic process (GO:0009070) | 3.98792676 |
| 91 | positive regulation of hemostasis (GO:1900048) | 3.97065199 |
| 92 | positive regulation of blood coagulation (GO:0030194) | 3.97065199 |
| 93 | regulation of bile acid biosynthetic process (GO:0070857) | 3.96615919 |
| 94 | acute-phase response (GO:0006953) | 3.95908404 |
| 95 | cellular modified amino acid catabolic process (GO:0042219) | 3.94328182 |
| 96 | drug catabolic process (GO:0042737) | 3.92342187 |
| 97 | negative regulation of complement activation (GO:0045916) | 3.92178711 |
| 98 | ethanol oxidation (GO:0006069) | 3.92159139 |
| 99 | drug transmembrane transport (GO:0006855) | 3.91747919 |
| 100 | negative regulation of lipase activity (GO:0060192) | 3.90347747 |
| 101 | NAD biosynthetic process (GO:0009435) | 3.89945056 |
| 102 | low-density lipoprotein particle remodeling (GO:0034374) | 3.86169942 |
| 103 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.85218152 |
| 104 | complement activation, classical pathway (GO:0006958) | 3.85138954 |
| 105 | L-serine metabolic process (GO:0006563) | 3.82980485 |
| 106 | cofactor catabolic process (GO:0051187) | 3.79457816 |
| 107 | protein activation cascade (GO:0072376) | 3.78940974 |
| 108 | aldehyde catabolic process (GO:0046185) | 3.76053675 |
| 109 | complement activation (GO:0006956) | 3.75935463 |
| 110 | nicotinamide nucleotide biosynthetic process (GO:0019359) | 3.75221812 |
| 111 | pyridine nucleotide biosynthetic process (GO:0019363) | 3.75221812 |
| 112 | cholesterol homeostasis (GO:0042632) | 3.75204356 |
| 113 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.74174465 |
| 114 | S-adenosylmethionine metabolic process (GO:0046500) | 3.74016551 |
| 115 | cytolysis (GO:0019835) | 3.73598982 |
| 116 | carboxylic acid catabolic process (GO:0046395) | 3.73554658 |
| 117 | organic acid catabolic process (GO:0016054) | 3.73554658 |
| 118 | ketone body metabolic process (GO:1902224) | 3.72112537 |
| 119 | sterol homeostasis (GO:0055092) | 3.68807154 |
| 120 | plasma lipoprotein particle organization (GO:0071827) | 3.66901773 |
| 121 | opsonization (GO:0008228) | 3.64286609 |
| 122 | positive regulation of coagulation (GO:0050820) | 3.64212452 |
| 123 | acetyl-CoA metabolic process (GO:0006084) | 3.63909522 |
| 124 | phospholipid homeostasis (GO:0055091) | 3.63743898 |
| 125 | heme transport (GO:0015886) | 3.62340423 |
| 126 | positive regulation of lipid catabolic process (GO:0050996) | 3.61442463 |
| 127 | short-chain fatty acid metabolic process (GO:0046459) | 3.61025540 |
| 128 | glucuronate metabolic process (GO:0019585) | 3.54309493 |
| 129 | arginine catabolic process (GO:0006527) | 3.49492608 |
| 130 | glutamine family amino acid catabolic process (GO:0009065) | 3.44912468 |
| 131 | acute inflammatory response (GO:0002526) | 3.42998629 |
| 132 | xenobiotic metabolic process (GO:0006805) | 3.40605497 |
| 133 | flavonoid metabolic process (GO:0009812) | 3.33726972 |
| 134 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 3.33289541 |
| 135 | polyketide metabolic process (GO:0030638) | 3.31921678 |
| 136 | doxorubicin metabolic process (GO:0044598) | 3.31921678 |
| 137 | daunorubicin metabolic process (GO:0044597) | 3.31921678 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 8.12327303 |
| 2 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 7.32306212 |
| 3 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 6.94298736 |
| 4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 6.34231818 |
| 5 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 5.24306107 |
| 6 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 5.06915540 |
| 7 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.39076380 |
| 8 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 4.02475722 |
| 9 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 3.92569012 |
| 10 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 11.6003453 |
| 11 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.89152800 |
| 12 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.83927103 |
| 13 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.83042742 |
| 14 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.76891812 |
| 15 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.70864587 |
| 16 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.46849608 |
| 17 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.42713518 |
| 18 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.37459293 |
| 19 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.33852082 |
| 20 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.29715417 |
| 21 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.28037736 |
| 22 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.26879850 |
| 23 | * RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.26312961 |
| 24 | GATA1_22025678_ChIP-Seq_K562_Human | 1.23962494 |
| 25 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.21926563 |
| 26 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.21204141 |
| 27 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.10734824 |
| 28 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.10628639 |
| 29 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.08789163 |
| 30 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.07361951 |
| 31 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.02019376 |
| 32 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.95573572 |
| 33 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.95255827 |
| 34 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.94571092 |
| 35 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.92208106 |
| 36 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.91016386 |
| 37 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.90343422 |
| 38 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.89005690 |
| 39 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.88944067 |
| 40 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.85978045 |
| 41 | NFYA_21822215_ChIP-Seq_K562_Human | 0.85624043 |
| 42 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.83316895 |
| 43 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.83099832 |
| 44 | ERA_21632823_ChIP-Seq_H3396_Human | 0.83066135 |
| 45 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.82481609 |
| 46 | SA1_27219007_Chip-Seq_Bcells_Human | 0.82445613 |
| 47 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.82214932 |
| 48 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.81302331 |
| 49 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.80936799 |
| 50 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.79990150 |
| 51 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.79743943 |
| 52 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.78553257 |
| 53 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.78280671 |
| 54 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.77894887 |
| 55 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.77414012 |
| 56 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.76625867 |
| 57 | STAT1_17558387_ChIP-Seq_HELA_Human | 0.75232308 |
| 58 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.75048537 |
| 59 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.74498932 |
| 60 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.74143175 |
| 61 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.74067525 |
| 62 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.73922400 |
| 63 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.73711857 |
| 64 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.73152669 |
| 65 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.72980874 |
| 66 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.72442868 |
| 67 | * EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.72364135 |
| 68 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.72044086 |
| 69 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.72012791 |
| 70 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.71985482 |
| 71 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.71767084 |
| 72 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.71523628 |
| 73 | * GATA3_21867929_ChIP-Seq_CD8_Mouse | 0.70396617 |
| 74 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.69691146 |
| 75 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 0.68795839 |
| 76 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.68765756 |
| 77 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.67638464 |
| 78 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.67144236 |
| 79 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.67066878 |
| 80 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.66851408 |
| 81 | * JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.65581956 |
| 82 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 0.65537109 |
| 83 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.64864012 |
| 84 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.64701132 |
| 85 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.64144645 |
| 86 | P300_27268052_Chip-Seq_Bcells_Human | 0.63858248 |
| 87 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.63512454 |
| 88 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.63233486 |
| 89 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 0.62805713 |
| 90 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.62348448 |
| 91 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.61982567 |
| 92 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.61940295 |
| 93 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.61679351 |
| 94 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.61602647 |
| 95 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.61070290 |
| 96 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.60885650 |
| 97 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.60639180 |
| 98 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.60519120 |
| 99 | CTCF_21964334_Chip-Seq_Bcells_Human | 0.60266308 |
| 100 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.60166265 |
| 101 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.59793511 |
| 102 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.59139813 |
| 103 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.58936973 |
| 104 | CBP_21632823_ChIP-Seq_H3396_Human | 0.58678829 |
| 105 | NFYB_21822215_ChIP-Seq_K562_Human | 0.58175140 |
| 106 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.58131784 |
| 107 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.58100685 |
| 108 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.57738672 |
| 109 | * AR_20517297_ChIP-Seq_VCAP_Human | 0.57616328 |
| 110 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.57476208 |
| 111 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.57476208 |
| 112 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 0.56379776 |
| 113 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.56242801 |
| 114 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.56067240 |
| 115 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.55732841 |
| 116 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.55594462 |
| 117 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.55036591 |
| 118 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.54814855 |
| 119 | * NCOR_22424771_ChIP-Seq_293T_Human | 0.54316559 |
| 120 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.54197075 |
| 121 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.53934964 |
| 122 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.53257754 |
| 123 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.52715550 |
| 124 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.51359438 |
| 125 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.50661346 |
| 126 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.50284588 |
| 127 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.50216396 |
| 128 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.50174709 |
| 129 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.49940074 |
| 130 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.49664312 |
| 131 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.49402565 |
| 132 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 0.49150759 |
| 133 | ESRRB_18555785_Chip-Seq_ESCs_Mouse | 0.48244929 |
| 134 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.48207056 |
| 135 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.47159498 |
| 136 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.47055768 |
| 137 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.46905753 |
| 138 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.46152824 |
| 139 | PU1_27457419_Chip-Seq_LIVER_Mouse | 0.45948610 |
| 140 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.45293815 |
| 141 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.45116517 |
| 142 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.45050256 |
| 143 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.44935785 |
| 144 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.44846374 |
| 145 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.44097089 |
| 146 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.44067366 |
| 147 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.43794132 |
| 148 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.43760497 |
| 149 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.43688739 |
| 150 | * SPI1_26923725_Chip-Seq_HPCs_Mouse | 0.43368106 |
| 151 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.43136113 |
| 152 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.42637982 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002139_abnormal_hepatobiliary_system | 8.20663362 |
| 2 | MP0005360_urolithiasis | 7.48411855 |
| 3 | MP0005085_abnormal_gallbladder_physiolo | 6.51177668 |
| 4 | MP0005365_abnormal_bile_salt | 6.26748470 |
| 5 | MP0008875_abnormal_xenobiotic_pharmacok | 4.88986538 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 4.09465037 |
| 7 | MP0003252_abnormal_bile_duct | 3.82686648 |
| 8 | MP0010329_abnormal_lipoprotein_level | 3.57238440 |
| 9 | MP0009840_abnormal_foam_cell | 3.23431099 |
| 10 | MP0005083_abnormal_biliary_tract | 3.21190367 |
| 11 | MP0003195_calcinosis | 2.84007723 |
| 12 | MP0005332_abnormal_amino_acid | 2.72740733 |
| 13 | MP0001666_abnormal_nutrient_absorption | 2.53000868 |
| 14 | MP0003191_abnormal_cellular_cholesterol | 2.46435576 |
| 15 | MP0004019_abnormal_vitamin_homeostasis | 2.39564783 |
| 16 | MP0005451_abnormal_body_composition | 2.19709646 |
| 17 | MP0000609_abnormal_liver_physiology | 2.11902822 |
| 18 | MP0002118_abnormal_lipid_homeostasis | 2.09703410 |
| 19 | MP0002138_abnormal_hepatobiliary_system | 2.01286391 |
| 20 | MP0003868_abnormal_feces_composition | 1.87613966 |
| 21 | MP0001764_abnormal_homeostasis | 1.77936571 |
| 22 | MP0009697_abnormal_copulation | 1.77754304 |
| 23 | MP0005319_abnormal_enzyme/_coenzyme | 1.75749309 |
| 24 | MP0003011_delayed_dark_adaptation | 1.54650172 |
| 25 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.40834453 |
| 26 | MP0005647_abnormal_sex_gland | 1.30661385 |
| 27 | MP0005187_abnormal_penis_morphology | 1.25074925 |
| 28 | MP0003186_abnormal_redox_activity | 1.21470350 |
| 29 | MP0009764_decreased_sensitivity_to | 1.19251371 |
| 30 | MP0009643_abnormal_urine_homeostasis | 1.18965394 |
| 31 | MP0003656_abnormal_erythrocyte_physiolo | 1.18766166 |
| 32 | MP0010368_abnormal_lymphatic_system | 1.17168309 |
| 33 | MP0000598_abnormal_liver_morphology | 1.08309373 |
| 34 | MP0005670_abnormal_white_adipose | 1.06806404 |
| 35 | MP0005084_abnormal_gallbladder_morpholo | 0.99736345 |
| 36 | MP0001986_abnormal_taste_sensitivity | 0.99349850 |
| 37 | MP0009763_increased_sensitivity_to | 0.98767769 |
| 38 | MP0001915_intracranial_hemorrhage | 0.96923326 |
| 39 | MP0005636_abnormal_mineral_homeostasis | 0.94297960 |
| 40 | MP0002254_reproductive_system_inflammat | 0.93010159 |
| 41 | MP0002876_abnormal_thyroid_physiology | 0.90487152 |
| 42 | MP0008469_abnormal_protein_level | 0.89440006 |
| 43 | MP0003718_maternal_effect | 0.84558315 |
| 44 | MP0001661_extended_life_span | 0.84409291 |
| 45 | MP0009642_abnormal_blood_homeostasis | 0.84381479 |
| 46 | MP0005058_abnormal_lysosome_morphology | 0.84040409 |
| 47 | MP0000604_amyloidosis | 0.82853195 |
| 48 | MP0003705_abnormal_hypodermis_morpholog | 0.80582217 |
| 49 | MP0010386_abnormal_urinary_bladder | 0.80564068 |
| 50 | MP0006036_abnormal_mitochondrial_physio | 0.79997547 |
| 51 | MP0005376_homeostasis/metabolism_phenot | 0.78062301 |
| 52 | MP0004381_abnormal_hair_follicle | 0.77657714 |
| 53 | MP0005408_hypopigmentation | 0.76565305 |
| 54 | MP0009765_abnormal_xenobiotic_induced | 0.73586165 |
| 55 | MP0002971_abnormal_brown_adipose | 0.73398899 |
| 56 | MP0005334_abnormal_fat_pad | 0.72401704 |
| 57 | MP0002090_abnormal_vision | 0.72039542 |
| 58 | MP0003724_increased_susceptibility_to | 0.70741901 |
| 59 | MP0002078_abnormal_glucose_homeostasis | 0.69923648 |
| 60 | MP0005220_abnormal_exocrine_pancreas | 0.66044188 |
| 61 | MP0005535_abnormal_body_temperature | 0.65332518 |
| 62 | MP0002132_abnormal_respiratory_system | 0.65237612 |
| 63 | MP0005395_other_phenotype | 0.64660257 |
| 64 | MP0004782_abnormal_surfactant_physiolog | 0.64266212 |
| 65 | MP0000579_abnormal_nail_morphology | 0.61280892 |
| 66 | MP0003690_abnormal_glial_cell | 0.60099395 |
| 67 | MP0005266_abnormal_metabolism | 0.60081298 |
| 68 | MP0001756_abnormal_urination | 0.59311231 |
| 69 | MP0000639_abnormal_adrenal_gland | 0.58864876 |
| 70 | MP0004130_abnormal_muscle_cell | 0.56670105 |
| 71 | MP0006035_abnormal_mitochondrial_morpho | 0.54559784 |
| 72 | MP0009053_abnormal_anal_canal | 0.49506781 |
| 73 | MP0005448_abnormal_energy_balance | 0.48449245 |
| 74 | MP0003879_abnormal_hair_cell | 0.48147809 |
| 75 | MP0003959_abnormal_lean_body | 0.46071036 |
| 76 | MP0002136_abnormal_kidney_physiology | 0.45776903 |
| 77 | MP0005666_abnormal_adipose_tissue | 0.43535413 |
| 78 | MP0008874_decreased_physiological_sensi | 0.43393160 |
| 79 | MP0002928_abnormal_bile_duct | 0.41892915 |
| 80 | MP0000566_synostosis | 0.41406077 |
| 81 | MP0005464_abnormal_platelet_physiology | 0.40610802 |
| 82 | MP0003953_abnormal_hormone_level | 0.40408100 |
| 83 | MP0008260_abnormal_autophagy | 0.39823003 |
| 84 | MP0003638_abnormal_response/metabolism_ | 0.37361437 |
| 85 | MP0002822_catalepsy | 0.37281304 |
| 86 | MP0009115_abnormal_fat_cell | 0.36910776 |
| 87 | MP0006082_CNS_inflammation | 0.35856150 |
| 88 | MP0005166_decreased_susceptibility_to | 0.35648537 |
| 89 | MP0005645_abnormal_hypothalamus_physiol | 0.34666431 |
| 90 | MP0008872_abnormal_physiological_respon | 0.34575530 |
| 91 | MP0000230_abnormal_systemic_arterial | 0.34478637 |
| 92 | MP0002332_abnormal_exercise_endurance | 0.34012850 |
| 93 | MP0005248_abnormal_Harderian_gland | 0.33357254 |
| 94 | MP0009384_cardiac_valve_regurgitation | 0.33221971 |
| 95 | MP0005197_abnormal_uvea_morphology | 0.32586005 |
| 96 | MP0003329_amyloid_beta_deposits | 0.32547697 |
| 97 | MP0002168_other_aberrant_phenotype | 0.32365911 |
| 98 | MP0004147_increased_porphyrin_level | 0.31187570 |
| 99 | MP0002089_abnormal_postnatal_growth/wei | 0.30661344 |
| 100 | MP0008873_increased_physiological_sensi | 0.30308885 |
| 101 | MP0009672_abnormal_birth_weight | 0.30261020 |
| 102 | MP0001881_abnormal_mammary_gland | 0.29674509 |
| 103 | MP0002796_impaired_skin_barrier | 0.28858591 |
| 104 | MP0004883_abnormal_blood_vessel | 0.28678225 |
| 105 | MP0000249_abnormal_blood_vessel | 0.28337468 |
| 106 | MP0000427_abnormal_hair_cycle | 0.27591897 |
| 107 | MP0003075_altered_response_to | 0.27114486 |
| 108 | MP0002282_abnormal_trachea_morphology | 0.25032463 |
| 109 | MP0005595_abnormal_vascular_smooth | 0.24831418 |
| 110 | MP0003699_abnormal_female_reproductive | 0.24778704 |
| 111 | MP0001853_heart_inflammation | 0.24775013 |
| 112 | MP0002970_abnormal_white_adipose | 0.24575512 |
| 113 | MP0002837_dystrophic_cardiac_calcinosis | 0.24537222 |
| 114 | MP0009333_abnormal_splenocyte_physiolog | 0.24316066 |
| 115 | MP0005410_abnormal_fertilization | 0.23743542 |
| 116 | MP0000462_abnormal_digestive_system | 0.23353896 |
| 117 | MP0001440_abnormal_grooming_behavior | 0.20764841 |
| 118 | MP0001845_abnormal_inflammatory_respons | 0.18131676 |
| 119 | MP0003646_muscle_fatigue | 0.16424642 |
| 120 | MP0002249_abnormal_larynx_morphology | 0.15573870 |
| 121 | MP0005164_abnormal_response_to | 0.14275326 |
| 122 | MP0009785_altered_susceptibility_to | 0.11661681 |
| 123 | MP0005023_abnormal_wound_healing | 0.11082413 |
| 124 | MP0000467_abnormal_esophagus_morphology | 0.10556841 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Intrahepatic cholestasis (HP:0001406) | 7.25599564 |
| 2 | Deep venous thrombosis (HP:0002625) | 7.25360962 |
| 3 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 7.25176507 |
| 4 | Prolonged partial thromboplastin time (HP:0003645) | 6.73524336 |
| 5 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 6.45444082 |
| 6 | Hypobetalipoproteinemia (HP:0003563) | 6.16867032 |
| 7 | Xanthomatosis (HP:0000991) | 6.09962511 |
| 8 | Hyperlipoproteinemia (HP:0010980) | 5.62405862 |
| 9 | Complement deficiency (HP:0004431) | 5.44082578 |
| 10 | Hyperglycinemia (HP:0002154) | 5.06274337 |
| 11 | Joint hemorrhage (HP:0005261) | 5.03505046 |
| 12 | Reduced antithrombin III activity (HP:0001976) | 4.86691141 |
| 13 | Hypolipoproteinemia (HP:0010981) | 4.78071235 |
| 14 | Hyperammonemia (HP:0001987) | 4.49557970 |
| 15 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 4.37280466 |
| 16 | Hyperglycinuria (HP:0003108) | 4.36995068 |
| 17 | Hypoalphalipoproteinemia (HP:0003233) | 4.35636898 |
| 18 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.30882659 |
| 19 | Abnormality of glycine metabolism (HP:0010895) | 4.30882659 |
| 20 | Abnormality of the common coagulation pathway (HP:0010990) | 4.26261783 |
| 21 | Abnormality of methionine metabolism (HP:0010901) | 4.21273058 |
| 22 | Epidermoid cyst (HP:0200040) | 4.16399151 |
| 23 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.12307415 |
| 24 | Fat malabsorption (HP:0002630) | 4.10458848 |
| 25 | Ketosis (HP:0001946) | 4.06207211 |
| 26 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.02459523 |
| 27 | Conjugated hyperbilirubinemia (HP:0002908) | 3.99776515 |
| 28 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.97426226 |
| 29 | Hypoglycemic coma (HP:0001325) | 3.95320922 |
| 30 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.93502079 |
| 31 | Abnormality of complement system (HP:0005339) | 3.88909560 |
| 32 | Abnormality of the intrinsic pathway (HP:0010989) | 3.75808685 |
| 33 | Osteomalacia (HP:0002749) | 3.57372470 |
| 34 | Hypercholesterolemia (HP:0003124) | 3.44832731 |
| 35 | Abnormality of serum amino acid levels (HP:0003112) | 3.40814302 |
| 36 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.30277539 |
| 37 | Hyperbilirubinemia (HP:0002904) | 3.22208608 |
| 38 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.21377935 |
| 39 | Steatorrhea (HP:0002570) | 3.19816862 |
| 40 | Spontaneous abortion (HP:0005268) | 3.14155165 |
| 41 | Delayed CNS myelination (HP:0002188) | 3.13512829 |
| 42 | Abnormality of nucleobase metabolism (HP:0010932) | 3.11730959 |
| 43 | Myocardial infarction (HP:0001658) | 3.11417461 |
| 44 | Hypochromic microcytic anemia (HP:0004840) | 2.96391581 |
| 45 | Hepatocellular carcinoma (HP:0001402) | 2.83512532 |
| 46 | Nephritis (HP:0000123) | 2.83506276 |
| 47 | Systemic lupus erythematosus (HP:0002725) | 2.77847609 |
| 48 | Vascular calcification (HP:0004934) | 2.77629460 |
| 49 | Metabolic acidosis (HP:0001942) | 2.76966052 |
| 50 | Ketoacidosis (HP:0001993) | 2.76387346 |
| 51 | Dicarboxylic aciduria (HP:0003215) | 2.76200911 |
| 52 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.76200911 |
| 53 | Lethargy (HP:0001254) | 2.74600329 |
| 54 | Abnormality of purine metabolism (HP:0004352) | 2.68883325 |
| 55 | Hyperphosphaturia (HP:0003109) | 2.59122063 |
| 56 | Hypoglycemic seizures (HP:0002173) | 2.58027313 |
| 57 | Abnormality of urine glucose concentration (HP:0011016) | 2.51493864 |
| 58 | Cerebral edema (HP:0002181) | 2.49248007 |
| 59 | Gout (HP:0001997) | 2.48351301 |
| 60 | Pulmonary embolism (HP:0002204) | 2.47924482 |
| 61 | Skin nodule (HP:0200036) | 2.45074529 |
| 62 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.44211878 |
| 63 | Cardiovascular calcification (HP:0011915) | 2.43614063 |
| 64 | Abnormal biliary tract physiology (HP:0012439) | 2.42174130 |
| 65 | Bile duct proliferation (HP:0001408) | 2.42174130 |
| 66 | Amyloidosis (HP:0011034) | 2.38707571 |
| 67 | Elevated alkaline phosphatase (HP:0003155) | 2.38483972 |
| 68 | Mitral stenosis (HP:0001718) | 2.37936560 |
| 69 | Abnormal pupillary function (HP:0007686) | 2.34946785 |
| 70 | Glomerulonephritis (HP:0000099) | 2.34291029 |
| 71 | Abnormal gallbladder morphology (HP:0012437) | 2.32813426 |
| 72 | Purpura (HP:0000979) | 2.31874745 |
| 73 | Acanthocytosis (HP:0001927) | 2.31179907 |
| 74 | Cholelithiasis (HP:0001081) | 2.28524278 |
| 75 | Irritability (HP:0000737) | 2.26849013 |
| 76 | Renal cortical cysts (HP:0000803) | 2.26464265 |
| 77 | Enlarged kidneys (HP:0000105) | 2.25435095 |
| 78 | Gingival bleeding (HP:0000225) | 2.24172163 |
| 79 | Abnormality of alkaline phosphatase activity (HP:0004379) | 2.24073025 |
| 80 | Abnormality of the Achilles tendon (HP:0005109) | 2.21414011 |
| 81 | Pancreatitis (HP:0001733) | 2.21145608 |
| 82 | Spastic diplegia (HP:0001264) | 2.18979110 |
| 83 | Menorrhagia (HP:0000132) | 2.17667767 |
| 84 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.17553159 |
| 85 | Increased serum ferritin (HP:0003281) | 2.17190253 |
| 86 | Esophageal varix (HP:0002040) | 2.17079396 |
| 87 | Neonatal onset (HP:0003623) | 2.15736832 |
| 88 | Hypophosphatemic rickets (HP:0004912) | 2.14765293 |
| 89 | Opisthotonus (HP:0002179) | 2.13916205 |
| 90 | Abnormal gallbladder physiology (HP:0012438) | 2.13652013 |
| 91 | Cholecystitis (HP:0001082) | 2.13652013 |
| 92 | Malnutrition (HP:0004395) | 2.13645157 |
| 93 | Brushfield spots (HP:0001088) | 2.13391486 |
| 94 | Abnormal urine phosphate concentration (HP:0012599) | 2.10873644 |
| 95 | Neonatal hypoglycemia (HP:0001998) | 2.08155159 |
| 96 | Hyperglycemia (HP:0003074) | 2.07173842 |
| 97 | Vomiting (HP:0002013) | 2.06862474 |
| 98 | Rickets (HP:0002748) | 2.04527937 |
| 99 | Thrombophlebitis (HP:0004418) | 2.03342938 |
| 100 | Atrioventricular block (HP:0001678) | 2.02258322 |
| 101 | Sensorimotor neuropathy (HP:0007141) | 1.99259035 |
| 102 | Generalized aminoaciduria (HP:0002909) | 1.97520054 |
| 103 | Poikilocytosis (HP:0004447) | 1.97233818 |
| 104 | Arthropathy (HP:0003040) | 1.96998553 |
| 105 | Hemorrhage of the eye (HP:0011885) | 1.95602958 |
| 106 | Late onset (HP:0003584) | 1.91477249 |
| 107 | Alkalosis (HP:0001948) | 1.91013779 |
| 108 | Gangrene (HP:0100758) | 1.88981637 |
| 109 | Abnormality of the gallbladder (HP:0005264) | 1.88834664 |
| 110 | Proximal tubulopathy (HP:0000114) | 1.87288118 |
| 111 | Abnormality of iron homeostasis (HP:0011031) | 1.86778717 |
| 112 | Status epilepticus (HP:0002133) | 1.86762237 |
| 113 | Elevated hepatic transaminases (HP:0002910) | 1.86423144 |
| 114 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.83568751 |
| 115 | Fair hair (HP:0002286) | 1.83320945 |
| 116 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.82745828 |
| 117 | Increased serum pyruvate (HP:0003542) | 1.79203631 |
| 118 | Hydroxyprolinuria (HP:0003080) | 1.78238350 |
| 119 | Abnormality of proline metabolism (HP:0010907) | 1.78238350 |
| 120 | Paraparesis (HP:0002385) | 1.75297675 |
| 121 | Retinal atrophy (HP:0001105) | 1.74986835 |
| 122 | Nausea (HP:0002018) | 1.74848393 |
| 123 | Glycosuria (HP:0003076) | 1.73562083 |
| 124 | Abnormality of vitamin metabolism (HP:0100508) | 1.70780262 |
| 125 | Generalized hypopigmentation of hair (HP:0011358) | 1.67319895 |
| 126 | Decreased subcutaneous fat (HP:0001002) | 1.56890720 |
| 127 | Hypophosphatemia (HP:0002148) | 1.55613511 |
| 128 | Abnormality of glycolysis (HP:0004366) | 1.54199660 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BCKDK | 6.60277290 |
| 2 | FGFR4 | 4.52218138 |
| 3 | SIK1 | 4.09695946 |
| 4 | INSRR | 3.86996839 |
| 5 | ERN1 | 3.38297003 |
| 6 | LMTK2 | 3.14902427 |
| 7 | TAOK3 | 3.13791334 |
| 8 | ERBB4 | 3.01981278 |
| 9 | PIK3CG | 2.59031049 |
| 10 | MUSK | 2.18092685 |
| 11 | MST1R | 2.13965689 |
| 12 | LATS1 | 2.09304839 |
| 13 | ARAF | 1.99394131 |
| 14 | TESK2 | 1.98078959 |
| 15 | MAPK11 | 1.90966891 |
| 16 | IRAK3 | 1.85180032 |
| 17 | STK16 | 1.83376667 |
| 18 | PRPF4B | 1.81628692 |
| 19 | MAP2K4 | 1.79272893 |
| 20 | PINK1 | 1.71244390 |
| 21 | STK38L | 1.71075410 |
| 22 | TIE1 | 1.58369002 |
| 23 | NEK9 | 1.54754274 |
| 24 | GRK1 | 1.54572519 |
| 25 | BMX | 1.53313764 |
| 26 | KDR | 1.47032552 |
| 27 | RIPK1 | 1.40399448 |
| 28 | TYK2 | 1.36476428 |
| 29 | PRKAA2 | 1.36126313 |
| 30 | DAPK2 | 1.33496469 |
| 31 | MAP3K12 | 1.32736820 |
| 32 | MAP3K14 | 1.31422674 |
| 33 | AKT3 | 1.28913340 |
| 34 | ABL2 | 1.19680137 |
| 35 | FLT3 | 1.18823811 |
| 36 | EIF2AK1 | 1.18457539 |
| 37 | ZAK | 1.17869421 |
| 38 | NEK1 | 1.16360790 |
| 39 | MAPK15 | 1.15792412 |
| 40 | EIF2AK2 | 1.13003175 |
| 41 | MYLK | 1.06510193 |
| 42 | FGFR2 | 1.06502049 |
| 43 | JAK1 | 1.06084180 |
| 44 | PHKG1 | 1.05764177 |
| 45 | PHKG2 | 1.05764177 |
| 46 | EPHA3 | 1.03805715 |
| 47 | PRKG1 | 1.03424147 |
| 48 | MAPK12 | 1.00859791 |
| 49 | BUB1 | 0.96163108 |
| 50 | JAK2 | 0.93856498 |
| 51 | TAOK2 | 0.93423723 |
| 52 | FRK | 0.93204140 |
| 53 | MAPK4 | 0.91858212 |
| 54 | PDK2 | 0.87247849 |
| 55 | MAPK7 | 0.86919461 |
| 56 | EIF2AK3 | 0.86236160 |
| 57 | PRKAA1 | 0.83471243 |
| 58 | EPHB1 | 0.83294497 |
| 59 | ERBB2 | 0.82642661 |
| 60 | TBK1 | 0.82456351 |
| 61 | SRPK1 | 0.82139322 |
| 62 | AURKA | 0.82025402 |
| 63 | PRKCZ | 0.79837570 |
| 64 | PKN1 | 0.79674865 |
| 65 | PBK | 0.79647633 |
| 66 | PTK6 | 0.78683058 |
| 67 | STK4 | 0.77780861 |
| 68 | SCYL2 | 0.76753105 |
| 69 | CSNK2A1 | 0.75685068 |
| 70 | MAP3K7 | 0.74656404 |
| 71 | CSNK2A2 | 0.74488794 |
| 72 | CSNK1D | 0.73410447 |
| 73 | NUAK1 | 0.73355532 |
| 74 | PDK3 | 0.72894834 |
| 75 | PDK4 | 0.72894834 |
| 76 | CAMK2G | 0.72855058 |
| 77 | TGFBR2 | 0.72575066 |
| 78 | PRKACG | 0.71721846 |
| 79 | SGK1 | 0.69184440 |
| 80 | TESK1 | 0.66831099 |
| 81 | MAP3K3 | 0.66576350 |
| 82 | CSK | 0.66227747 |
| 83 | MAP3K9 | 0.64959154 |
| 84 | DYRK2 | 0.64300538 |
| 85 | GSK3A | 0.63880413 |
| 86 | CSNK1G1 | 0.62779500 |
| 87 | MET | 0.62537280 |
| 88 | PRKCB | 0.60748226 |
| 89 | MAP2K6 | 0.60192100 |
| 90 | TTK | 0.59718829 |
| 91 | WNK3 | 0.59695417 |
| 92 | EPHA2 | 0.57557964 |
| 93 | PIM2 | 0.57390523 |
| 94 | OBSCN | 0.57021900 |
| 95 | IKBKE | 0.55978715 |
| 96 | IRAK1 | 0.55128539 |
| 97 | PKN2 | 0.53561488 |
| 98 | STK3 | 0.53232112 |
| 99 | RPS6KA3 | 0.53080601 |
| 100 | BRAF | 0.52750356 |
| 101 | MAP3K11 | 0.52749921 |
| 102 | NLK | 0.52739496 |
| 103 | CSNK1A1 | 0.52152907 |
| 104 | MAP3K1 | 0.51215756 |
| 105 | MAP2K3 | 0.50599305 |
| 106 | EPHB2 | 0.49769240 |
| 107 | MAP2K2 | 0.48682708 |
| 108 | GRK6 | 0.48618378 |
| 109 | TNK2 | 0.48431768 |
| 110 | SGK2 | 0.47729479 |
| 111 | MAP3K8 | 0.47237600 |
| 112 | CDK4 | 0.46863303 |
| 113 | CAMK1D | 0.46837700 |
| 114 | DYRK1B | 0.46756127 |
| 115 | CDK6 | 0.46572747 |
| 116 | PRKCG | 0.45503160 |
| 117 | PRKCI | 0.45455390 |
| 118 | BRSK1 | 0.45151396 |
| 119 | MAP3K5 | 0.45017212 |
| 120 | ILK | 0.44026333 |
| 121 | IGF1R | 0.43850125 |
| 122 | PAK1 | 0.43289876 |
| 123 | CASK | 0.43248792 |
| 124 | PDPK1 | 0.42764838 |
| 125 | PAK6 | 0.41922107 |
| 126 | PRKCQ | 0.41568603 |
| 127 | PLK1 | 0.41341869 |
| 128 | NME2 | 0.40149347 |
| 129 | MAP3K6 | 0.39779378 |
| 130 | LATS2 | 0.39435385 |
| 131 | NTRK3 | 0.39322070 |
| 132 | SGK3 | 0.38827645 |
| 133 | PDK1 | 0.36869714 |
| 134 | PIM1 | 0.36315062 |
| 135 | PIK3CA | 0.34835913 |
| 136 | CDC7 | 0.34215339 |
| 137 | PAK2 | 0.33117474 |
| 138 | PLK4 | 0.31189481 |
| 139 | CSNK1E | 0.31050760 |
| 140 | ADRBK2 | 0.30501843 |
| 141 | KSR2 | 0.30408252 |
| 142 | PRKCA | 0.30158119 |
| 143 | PRKCE | 0.30013708 |
| 144 | EPHA4 | 0.29792878 |
| 145 | IRAK2 | 0.29047656 |
| 146 | CSF1R | 0.29041134 |
| 147 | PRKACA | 0.28253841 |
| 148 | MAP2K1 | 0.28131311 |
| 149 | ABL1 | 0.27228791 |
| 150 | SGK494 | 0.25869120 |
| 151 | SGK223 | 0.25869120 |
| 152 | AKT2 | 0.25181006 |
| 153 | TRIB3 | 0.25039680 |
| 154 | TXK | 0.24641075 |
| 155 | PRKACB | 0.24405391 |
| 156 | BLK | 0.24141185 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.53648143 |
| 2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.19870874 |
| 3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.16980979 |
| 4 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.13174598 |
| 5 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.95238342 |
| 6 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.82946257 |
| 7 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.76245639 |
| 8 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.67508852 |
| 9 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.64514248 |
| 10 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.62201582 |
| 11 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.47026471 |
| 12 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.40121766 |
| 13 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.19736973 |
| 14 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.15022792 |
| 15 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.13583718 |
| 16 | Peroxisome_Homo sapiens_hsa04146 | 2.12368110 |
| 17 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.02528492 |
| 18 | Histidine metabolism_Homo sapiens_hsa00340 | 1.99173751 |
| 19 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.98426773 |
| 20 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.92600041 |
| 21 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.92536771 |
| 22 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.87683427 |
| 23 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.86824855 |
| 24 | Retinol metabolism_Homo sapiens_hsa00830 | 1.81703248 |
| 25 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.81441348 |
| 26 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.80951836 |
| 27 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.79034454 |
| 28 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.76746768 |
| 29 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.62700700 |
| 30 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.62422216 |
| 31 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.59185131 |
| 32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.57165686 |
| 33 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.55324858 |
| 34 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.53877716 |
| 35 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.53146751 |
| 36 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.48100284 |
| 37 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.42782495 |
| 38 | Bile secretion_Homo sapiens_hsa04976 | 1.41864508 |
| 39 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.34722084 |
| 40 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.31965618 |
| 41 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.29734510 |
| 42 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.29649330 |
| 43 | ABC transporters_Homo sapiens_hsa02010 | 1.27808322 |
| 44 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.26829898 |
| 45 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.24987693 |
| 46 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.22236079 |
| 47 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.15749627 |
| 48 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.14541390 |
| 49 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.10600441 |
| 50 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.08464395 |
| 51 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.07937270 |
| 52 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.07625635 |
| 53 | Carbon metabolism_Homo sapiens_hsa01200 | 1.04490374 |
| 54 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.04211421 |
| 55 | Sulfur relay system_Homo sapiens_hsa04122 | 1.00797876 |
| 56 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.00168074 |
| 57 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.97154216 |
| 58 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.87083784 |
| 59 | Lysine degradation_Homo sapiens_hsa00310 | 0.78663507 |
| 60 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.70089846 |
| 61 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.69735701 |
| 62 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.67517246 |
| 63 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.59417818 |
| 64 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.56130930 |
| 65 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.55127523 |
| 66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.52852949 |
| 67 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.52087764 |
| 68 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.37804260 |
| 69 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.34147769 |
| 70 | Prion diseases_Homo sapiens_hsa05020 | 0.34010312 |
| 71 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.29834647 |
| 72 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.26825096 |
| 73 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.25894662 |
| 74 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.24327465 |
| 75 | Galactose metabolism_Homo sapiens_hsa00052 | 0.22119202 |
| 76 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.15504600 |
| 77 | Insulin resistance_Homo sapiens_hsa04931 | 0.14528890 |
| 78 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.14437180 |
| 79 | Pertussis_Homo sapiens_hsa05133 | 0.12584945 |
| 80 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.07190730 |
| 81 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.04952143 |
| 82 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.03038094 |
| 83 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.00776767 |
| 84 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.00571836 |
| 85 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | -0.2617003 |
| 86 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | -0.2561128 |
| 87 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | -0.2480938 |
| 88 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | -0.2364761 |
| 89 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | -0.2307943 |
| 90 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.2307642 |
| 91 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | -0.2207130 |
| 92 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | -0.1895735 |
| 93 | Hepatitis C_Homo sapiens_hsa05160 | -0.1821353 |
| 94 | Type II diabetes mellitus_Homo sapiens_hsa04930 | -0.1735619 |
| 95 | Sphingolipid metabolism_Homo sapiens_hsa00600 | -0.1723994 |
| 96 | Pyrimidine metabolism_Homo sapiens_hsa00240 | -0.1717435 |
| 97 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | -0.1682869 |
| 98 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | -0.1668479 |
| 99 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.1642348 |
| 100 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | -0.1584329 |
| 101 | Amoebiasis_Homo sapiens_hsa05146 | -0.1533178 |
| 102 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | -0.1498439 |
| 103 | Ether lipid metabolism_Homo sapiens_hsa00565 | -0.1372710 |
| 104 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.1139954 |
| 105 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | -0.1119713 |
| 106 | African trypanosomiasis_Homo sapiens_hsa05143 | -0.0982007 |
| 107 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | -0.0881573 |
| 108 | Other glycan degradation_Homo sapiens_hsa00511 | -0.0594958 |
| 109 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.0339961 |
| 110 | Mineral absorption_Homo sapiens_hsa04978 | -0.0149726 |
| 111 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | -0.0144065 |

