RTP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)8.95742506
2sperm motility (GO:0030317)8.21637451
3response to pheromone (GO:0019236)8.05685513
4fusion of sperm to egg plasma membrane (GO:0007342)7.87047435
5sperm capacitation (GO:0048240)7.64935478
6chromosome condensation (GO:0030261)6.45646296
7negative regulation of inclusion body assembly (GO:0090084)6.31084690
8DNA packaging (GO:0006323)6.12056373
9plasma membrane fusion (GO:0045026)6.08547653
10calcium ion-dependent exocytosis (GO:0017156)6.04874942
11spermatid nucleus differentiation (GO:0007289)5.85941680
12single strand break repair (GO:0000012)5.65333032
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.50012256
14microtubule depolymerization (GO:0007019)5.42355240
15spermatid development (GO:0007286)5.31102416
16sexual reproduction (GO:0019953)5.29405820
17microtubule polymerization or depolymerization (GO:0031109)4.95893796
18sperm-egg recognition (GO:0035036)4.95309076
19multicellular organism reproduction (GO:0032504)4.88732327
20reproduction (GO:0000003)4.81594172
21regulation of synaptic vesicle exocytosis (GO:2000300)4.68605615
22regulation of inclusion body assembly (GO:0090083)4.66699891
23synaptic vesicle maturation (GO:0016188)4.66435338
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.59588495
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.46805721
26binding of sperm to zona pellucida (GO:0007339)4.38176364
27locomotory exploration behavior (GO:0035641)4.36827650
28phosphatidylethanolamine biosynthetic process (GO:0006646)4.30959535
29glutamate secretion (GO:0014047)4.19456159
30synaptic vesicle exocytosis (GO:0016079)4.16767281
31postsynaptic membrane organization (GO:0001941)4.15857244
32cell-cell recognition (GO:0009988)4.13083385
33positive regulation of Rab GTPase activity (GO:0032851)4.11041173
34regulation of Rab GTPase activity (GO:0032313)4.11041173
35sodium ion export (GO:0071436)4.06863530
36spermatogenesis (GO:0007283)3.99278903
37regulation of short-term neuronal synaptic plasticity (GO:0048172)3.99018911
38phosphatidylethanolamine metabolic process (GO:0046337)3.98666168
39male gamete generation (GO:0048232)3.97360508
40protein polyglutamylation (GO:0018095)3.96313993
41cellular ketone body metabolic process (GO:0046950)3.94529470
42protein targeting to Golgi (GO:0000042)3.91300058
43regulation of synaptic vesicle transport (GO:1902803)3.87070518
44chromatin silencing (GO:0006342)3.85187015
45establishment of protein localization to Golgi (GO:0072600)3.71328609
46cerebral cortex neuron differentiation (GO:0021895)3.69205895
47microtubule severing (GO:0051013)3.68945625
48axonemal dynein complex assembly (GO:0070286)3.68021488
49retrograde transport, vesicle recycling within Golgi (GO:0000301)3.66891469
50gamete generation (GO:0007276)3.60584182
51rRNA methylation (GO:0031167)3.59763143
52neuronal ion channel clustering (GO:0045161)3.59599522
53response to acidic pH (GO:0010447)3.56563424
54exploration behavior (GO:0035640)3.55923267
55regulation of transcription involved in cell fate commitment (GO:0060850)3.53937757
56ionotropic glutamate receptor signaling pathway (GO:0035235)3.51567767
57positive regulation of membrane potential (GO:0045838)3.45680958
58ketone body metabolic process (GO:1902224)3.43351869
59negative regulation of Rho protein signal transduction (GO:0035024)3.42007328
60L-amino acid import (GO:0043092)3.30802786
61regulation of ARF GTPase activity (GO:0032312)3.30132236
62regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.29475529
63regulation of ARF protein signal transduction (GO:0032012)3.22820793
64regulation of neuronal synaptic plasticity (GO:0048168)3.22673710
65neuron cell-cell adhesion (GO:0007158)3.22045446
66protein localization to synapse (GO:0035418)3.19408026
67coenzyme catabolic process (GO:0009109)3.18994171
68regulation of T-helper 2 cell differentiation (GO:0045628)3.16856552
69regulation of microtubule-based movement (GO:0060632)3.15956551
70membrane depolarization during action potential (GO:0086010)3.08746999
71neurotransmitter secretion (GO:0007269)3.08483464
72motile cilium assembly (GO:0044458)3.08358887
73membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.07838987
74cellular potassium ion homeostasis (GO:0030007)3.07586861
75RNA destabilization (GO:0050779)3.07127079
76positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.05821562
77regulation of cilium movement (GO:0003352)3.05801460
78regulation of interleukin-13 production (GO:0032656)3.04005352
79regulation of somitogenesis (GO:0014807)3.03989887
80single fertilization (GO:0007338)3.02304811
81synaptic transmission, glutamatergic (GO:0035249)3.00636846
82regulation of glutamate receptor signaling pathway (GO:1900449)2.98783306
83cellular response to pH (GO:0071467)2.93802363
84germ cell development (GO:0007281)2.92641424
85cellular process involved in reproduction in multicellular organism (GO:0022412)2.92563903
86actin filament capping (GO:0051693)2.92526218
87neuromuscular synaptic transmission (GO:0007274)2.92329282
88regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.89080932
89multicellular organismal reproductive process (GO:0048609)2.88845288
90dendritic spine organization (GO:0097061)2.87946724
91long-term memory (GO:0007616)2.87018240
92vocalization behavior (GO:0071625)2.86832620
93urinary tract smooth muscle contraction (GO:0014848)2.85847625
94regulation of long-term neuronal synaptic plasticity (GO:0048169)2.85222073
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84722279
96amino acid import (GO:0043090)2.79615363
97rRNA modification (GO:0000154)2.76774537
98vesicle transport along microtubule (GO:0047496)2.75449007
99cell wall macromolecule catabolic process (GO:0016998)2.74744034
100cranial nerve morphogenesis (GO:0021602)2.73118118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.93524875
2EZH2_22144423_ChIP-Seq_EOC_Human3.75934479
3DROSHA_22980978_ChIP-Seq_HELA_Human2.97433394
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95128879
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.53199303
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.52006758
7SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29771936
8REST_21632747_ChIP-Seq_MESCs_Mouse2.17903573
9EZH2_27294783_Chip-Seq_ESCs_Mouse2.09216726
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.06567838
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01981788
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00965624
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94504656
14CTCF_27219007_Chip-Seq_Bcells_Human1.94148869
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91167273
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87018371
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85540886
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84638971
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83984703
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83211594
21LXR_22292898_ChIP-Seq_THP-1_Human1.82233345
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.81671551
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79553105
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79553105
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.79300490
26ELF1_20517297_ChIP-Seq_JURKAT_Human1.76629600
27SMC4_20622854_ChIP-Seq_HELA_Human1.67062908
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.61491462
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59386638
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59386638
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55548838
32P68_20966046_ChIP-Seq_HELA_Human1.55189908
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53036710
34SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46150168
35RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40422806
36BCL6_27268052_Chip-Seq_Bcells_Human1.38200900
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.37184236
38EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37056229
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36327892
40ERA_21632823_ChIP-Seq_H3396_Human1.35106369
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34851750
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34791893
43BCOR_27268052_Chip-Seq_Bcells_Human1.33201459
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31276814
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.30911698
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.30797558
47E2F1_20622854_ChIP-Seq_HELA_Human1.29968618
48RUNX_20019798_ChIP-Seq_JUKART_Human1.29714249
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29281624
50CTCF_20526341_ChIP-Seq_ESCs_Human1.29106450
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28729673
52KDM2B_26808549_Chip-Seq_K562_Human1.27656760
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27191203
54TP63_22573176_ChIP-Seq_HFKS_Human1.23946890
55SA1_27219007_Chip-Seq_Bcells_Human1.21838553
56RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21668795
57EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20804719
58AR_21572438_ChIP-Seq_LNCaP_Human1.20789934
59RAC3_21632823_ChIP-Seq_H3396_Human1.19416194
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.18812598
61OCT4_19829295_ChIP-Seq_ESCs_Human1.16690235
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16294964
63TAF2_19829295_ChIP-Seq_ESCs_Human1.16046484
64PHF8_20622854_ChIP-Seq_HELA_Human1.15653349
65KLF4_19829295_ChIP-Seq_ESCs_Human1.14676907
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14201479
67CBP_20019798_ChIP-Seq_JUKART_Human1.14201479
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14071325
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10655454
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.10619261
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09712277
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09398353
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08903168
74RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07798597
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07349092
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.05293258
77MYC_19829295_ChIP-Seq_ESCs_Human1.04402696
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.04325851
79KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04250853
80OCT4_20526341_ChIP-Seq_ESCs_Human1.03030828
81NANOG_20526341_ChIP-Seq_ESCs_Human1.02677515
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00307345
83SMAD3_21741376_ChIP-Seq_ESCs_Human0.99833632
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98639774
85P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96885329
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96220471
87SMAD4_21741376_ChIP-Seq_HESCs_Human0.96066432
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95217195
89KDM2B_26808549_Chip-Seq_DND41_Human0.94235755
90MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92887483
91FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92392778
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.91885292
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91433710
94P300_27268052_Chip-Seq_Bcells_Human0.90678371
95ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90501546
96SMAD4_21741376_ChIP-Seq_ESCs_Human0.90468061
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.88484566
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.88349636
99RING1B_27294783_Chip-Seq_ESCs_Mouse0.88238030
100AR_25329375_ChIP-Seq_VCAP_Human0.87910410

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.50717691
2MP0004859_abnormal_synaptic_plasticity5.44227578
3MP0005423_abnormal_somatic_nervous3.78286563
4MP0003880_abnormal_central_pattern3.45946834
5MP0003635_abnormal_synaptic_transmissio3.11264518
6MP0004270_analgesia2.85972548
7MP0001486_abnormal_startle_reflex2.77629310
8MP0005670_abnormal_white_adipose2.76791147
9MP0003698_abnormal_male_reproductive2.72671708
10MP0003878_abnormal_ear_physiology2.70225941
11MP0005377_hearing/vestibular/ear_phenot2.70225941
12MP0001968_abnormal_touch/_nociception2.67920043
13MP0001348_abnormal_lacrimal_gland2.61537066
14MP0002064_seizures2.57046418
15MP0009745_abnormal_behavioral_response2.50143583
16MP0002063_abnormal_learning/memory/cond2.34223479
17MP0002735_abnormal_chemical_nociception2.23037300
18MP0002734_abnormal_mechanical_nocicepti2.22393090
19MP0002272_abnormal_nervous_system2.21514559
20MP0002572_abnormal_emotion/affect_behav2.17092190
21MP0001929_abnormal_gametogenesis2.08124803
22MP0003879_abnormal_hair_cell1.98559282
23MP0008569_lethality_at_weaning1.91984226
24MP0002733_abnormal_thermal_nociception1.89783258
25MP0004510_myositis1.88167797
26MP0001501_abnormal_sleep_pattern1.87255289
27MP0001970_abnormal_pain_threshold1.79216977
28MP0003329_amyloid_beta_deposits1.79007687
29MP0002822_catalepsy1.69206224
30MP0000678_abnormal_parathyroid_gland1.64331305
31MP0004742_abnormal_vestibular_system1.61053676
32MP0009046_muscle_twitch1.56947822
33MP0004885_abnormal_endolymph1.55818395
34MP0002161_abnormal_fertility/fecundity1.53554830
35MP0002067_abnormal_sensory_capabilities1.51402145
36MP0002736_abnormal_nociception_after1.48923678
37MP0001485_abnormal_pinna_reflex1.44791099
38MP0002557_abnormal_social/conspecific_i1.43649278
39MP0001502_abnormal_circadian_rhythm1.43434191
40MP0003690_abnormal_glial_cell1.42184685
41MP0000955_abnormal_spinal_cord1.41749941
42MP0003011_delayed_dark_adaptation1.36794987
43MP0002249_abnormal_larynx_morphology1.30924387
44MP0001440_abnormal_grooming_behavior1.28558609
45MP0001905_abnormal_dopamine_level1.26833449
46MP0004811_abnormal_neuron_physiology1.26643261
47MP0001984_abnormal_olfaction1.25634191
48MP0001963_abnormal_hearing_physiology1.24831756
49MP0003633_abnormal_nervous_system1.24109477
50MP0000920_abnormal_myelination1.19698937
51MP0002132_abnormal_respiratory_system1.15752811
52MP0002229_neurodegeneration1.14965637
53MP0002882_abnormal_neuron_morphology1.13595581
54MP0003787_abnormal_imprinting1.11651997
55MP0005167_abnormal_blood-brain_barrier1.10014870
56MP0003631_nervous_system_phenotype1.09484282
57MP0002638_abnormal_pupillary_reflex1.08656554
58MP0005646_abnormal_pituitary_gland1.07325561
59MP0003172_abnormal_lysosome_physiology1.06419855
60MP0006276_abnormal_autonomic_nervous1.04716243
61MP0001765_abnormal_ion_homeostasis1.00349166
62MP0008877_abnormal_DNA_methylation0.95951966
63MP0000778_abnormal_nervous_system0.95643817
64MP0000026_abnormal_inner_ear0.95384174
65MP0002066_abnormal_motor_capabilities/c0.94194206
66MP0005535_abnormal_body_temperature0.93401502
67MP0005379_endocrine/exocrine_gland_phen0.93217745
68MP0009780_abnormal_chondrocyte_physiolo0.92304479
69MP0002234_abnormal_pharynx_morphology0.92209938
70MP0002653_abnormal_ependyma_morphology0.91460332
71MP0008874_decreased_physiological_sensi0.91120815
72MP0005310_abnormal_salivary_gland0.89282689
73MP0003646_muscle_fatigue0.86853454
74MP0000604_amyloidosis0.85095340
75MP0000681_abnormal_thyroid_gland0.84382547
76MP0005166_decreased_susceptibility_to0.84211042
77MP0005551_abnormal_eye_electrophysiolog0.83230110
78MP0003632_abnormal_nervous_system0.75331080
79MP0003634_abnormal_glial_cell0.74429815
80MP0002152_abnormal_brain_morphology0.73957132
81MP0002210_abnormal_sex_determination0.69407514
82MP0004142_abnormal_muscle_tone0.68787519
83MP0005386_behavior/neurological_phenoty0.67607115
84MP0004924_abnormal_behavior0.67607115
85MP0000534_abnormal_ureter_morphology0.66001837
86MP0005645_abnormal_hypothalamus_physiol0.61452684
87MP0003075_altered_response_to0.60778421
88MP0002184_abnormal_innervation0.60662044
89MP0003183_abnormal_peptide_metabolism0.60075465
90MP0004085_abnormal_heartbeat0.59131869
91MP0002069_abnormal_eating/drinking_beha0.57520222
92MP0004130_abnormal_muscle_cell0.55931617
93MP0002282_abnormal_trachea_morphology0.55524806
94MP0001986_abnormal_taste_sensitivity0.53918701
95MP0004484_altered_response_of0.53383227
96MP0001145_abnormal_male_reproductive0.53057154
97MP0000653_abnormal_sex_gland0.49943483
98MP0003137_abnormal_impulse_conducting0.49419734
99MP0002752_abnormal_somatic_nervous0.48722134
100MP0001177_atelectasis0.47926757

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.24417686
2Severe visual impairment (HP:0001141)6.17284213
3Resting tremor (HP:0002322)4.22799345
4Postural instability (HP:0002172)4.21717454
5Focal motor seizures (HP:0011153)4.14528064
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.94609446
7Absent/shortened dynein arms (HP:0200106)3.94609446
8Attenuation of retinal blood vessels (HP:0007843)3.79588287
9Bony spicule pigmentary retinopathy (HP:0007737)3.74726122
10Peripheral hypomyelination (HP:0007182)3.69291161
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.67886869
12Action tremor (HP:0002345)3.67526289
13Progressive cerebellar ataxia (HP:0002073)3.64944734
14Asymmetric septal hypertrophy (HP:0001670)3.50104921
15Atonic seizures (HP:0010819)3.45792569
16Focal seizures (HP:0007359)3.41592844
17Diplopia (HP:0000651)3.38722437
18Abnormality of binocular vision (HP:0011514)3.38722437
19Abnormal rod and cone electroretinograms (HP:0008323)3.36848785
20Bell-shaped thorax (HP:0001591)3.35878077
21Epileptic encephalopathy (HP:0200134)3.23405277
22Hypoplastic ischia (HP:0003175)3.21356726
23Enlarged epiphyses (HP:0010580)3.10631269
24Facial shape deformation (HP:0011334)3.05509493
25Potter facies (HP:0002009)3.05509493
26Febrile seizures (HP:0002373)3.02908114
27Hyperkalemia (HP:0002153)3.02278913
28Abnormality of the ischium (HP:0003174)2.99512771
29Nasal polyposis (HP:0100582)2.97280657
30Abnormal ciliary motility (HP:0012262)2.95296883
31Unilateral renal agenesis (HP:0000122)2.86125166
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.86010981
33Infertility (HP:0000789)2.80935236
34Abnormal respiratory motile cilium morphology (HP:0005938)2.74733825
35Abnormal respiratory epithelium morphology (HP:0012253)2.74733825
36Bowel incontinence (HP:0002607)2.74275653
37Abnormal respiratory motile cilium physiology (HP:0012261)2.74082170
38Papilledema (HP:0001085)2.72576420
39Amblyopia (HP:0000646)2.69212064
40Congenital malformation of the right heart (HP:0011723)2.67784343
41Double outlet right ventricle (HP:0001719)2.67784343
42Supranuclear gaze palsy (HP:0000605)2.67740847
43Delusions (HP:0000746)2.63234757
44Abnormality of macular pigmentation (HP:0008002)2.62515372
45Cerebral inclusion bodies (HP:0100314)2.62127045
46Stereotypic behavior (HP:0000733)2.61973565
47Ankle clonus (HP:0011448)2.60366536
48Bradykinesia (HP:0002067)2.58592966
49Abnormality of the aortic arch (HP:0012303)2.57218265
50Male infertility (HP:0003251)2.56519920
51Hypoplasia of the thymus (HP:0000778)2.53615353
52Neurofibrillary tangles (HP:0002185)2.53597991
53Abnormal large intestine physiology (HP:0012700)2.50819134
54Dysmetria (HP:0001310)2.50793996
55Hyperthyroidism (HP:0000836)2.50171713
56Intention tremor (HP:0002080)2.45050199
57Visual hallucinations (HP:0002367)2.44979879
58Hemiplegia (HP:0002301)2.44902383
59Obstructive sleep apnea (HP:0002870)2.42569763
60Abnormal eating behavior (HP:0100738)2.40697568
61Aplasia/Hypoplasia of the earlobes (HP:0009906)2.33997621
62Abnormality of the nasal mucosa (HP:0000433)2.30734759
63Slow saccadic eye movements (HP:0000514)2.25554790
64Azoospermia (HP:0000027)2.24569347
65Truncus arteriosus (HP:0001660)2.20394443
66Mutism (HP:0002300)2.19965198
67Absence seizures (HP:0002121)2.18357317
68Abnormal urine output (HP:0012590)2.16604361
69Impulsivity (HP:0100710)2.13208005
70Neoplasm of the heart (HP:0100544)2.10387452
71Spastic gait (HP:0002064)2.07944670
72Rigidity (HP:0002063)2.07018482
73Increased circulating renin level (HP:0000848)2.06565338
74Depression (HP:0000716)2.03572116
75Dialeptic seizures (HP:0011146)2.02368604
76Abnormal drinking behavior (HP:0030082)2.01449595
77Polydipsia (HP:0001959)2.01449595
78Abnormality of potassium homeostasis (HP:0011042)1.99770072
79Progressive sensorineural hearing impairment (HP:0000408)1.99561412
80Akinesia (HP:0002304)1.94915341
81Cerebral hypomyelination (HP:0006808)1.92216909
82Renal dysplasia (HP:0000110)1.90760901
83Abnormal spermatogenesis (HP:0008669)1.90218518
84Chronic hepatic failure (HP:0100626)1.89284006
85Torticollis (HP:0000473)1.88976932
86Epiphyseal dysplasia (HP:0002656)1.83360664
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83169479
88Dysdiadochokinesis (HP:0002075)1.82992881
89Sensory axonal neuropathy (HP:0003390)1.82542435
90Tetraplegia (HP:0002445)1.81501244
91Truncal obesity (HP:0001956)1.80382327
92Abnormality of saccadic eye movements (HP:0000570)1.78254928
93Limb dystonia (HP:0002451)1.77072260
94Abnormality of renal excretion (HP:0011036)1.74156159
95Polyuria (HP:0000103)1.71689476
96Insulin-resistant diabetes mellitus (HP:0000831)1.71276842
97Tubulointerstitial nephritis (HP:0001970)1.69381517
98Rapidly progressive (HP:0003678)1.68326259
99Mixed hearing impairment (HP:0000410)1.67663502
100Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67429463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.83285305
2PLK44.03765729
3DDR23.63612328
4PRKD33.28393156
5NTRK33.07617692
6MARK12.94855469
7EPHA42.85847583
8INSRR2.62169382
9STK382.53611221
10PLK22.51114848
11UHMK12.32733814
12PAK62.22549231
13SIK22.07846811
14DAPK21.99810378
15TNK21.98165276
16MAP4K21.96908729
17NTRK21.87197629
18MAP3K91.86201142
19RIPK41.77369718
20KSR21.76514126
21TYRO31.74213597
22PDK11.53888003
23NEK61.47574577
24PDPK11.46540782
25MARK21.42283574
26CAMKK11.40181281
27WNK11.37263679
28MAPK151.37055396
29MINK11.36305871
30LATS21.33095985
31CAMK11.24163067
32BRD41.23144817
33CAMK1G1.16539540
34MAP3K111.15136504
35FES1.15126582
36PRPF4B1.12039195
37CASK1.07757908
38PNCK1.01737426
39SGK2231.01523271
40SGK4941.01523271
41ARAF0.99804600
42DYRK1B0.98668995
43CDK50.96864039
44PRKCG0.93691859
45PKN10.88660670
46PRKCH0.87978849
47STK38L0.86404577
48CAMK40.83984864
49MAPK130.83076404
50NTRK10.82709812
51PHKG20.82243522
52PHKG10.82243522
53PRKG20.71611800
54GRK50.70012766
55MAP3K130.69367109
56MAPK120.62879408
57SGK20.61040208
58MAP3K20.61006033
59MAPK100.60908828
60RIPK10.59336898
61SGK10.59189328
62PTK2B0.58146557
63PRKCZ0.57978364
64CAMK2A0.56559323
65CDK190.55778509
66STK110.54896715
67PINK10.54674183
68MAP3K10.53641543
69PRKG10.53107780
70CAMK1D0.52198633
71ROCK10.52039156
72SGK30.51697057
73CDK11A0.50748187
74BRAF0.49809153
75RPS6KA20.49122157
76DYRK1A0.48433286
77CDK120.45342208
78JAK20.45055878
79GSK3B0.43651522
80MAPK80.43257188
81CDK140.41658513
82MAP3K70.40919585
83FYN0.40863294
84BRSK10.37725725
85MAP2K20.37606084
86RPS6KA30.35221925
87RPS6KA10.34632132
88SYK0.32257640
89CAMK2B0.31695910
90CDK150.30718068
91CAMK2G0.29937976
92CDK40.27495781
93PIK3CG0.27383892
94CDK70.26446206
95PRKCB0.26071854
96ROCK20.25888942
97CDK180.25869029
98RET0.25079123
99ALK0.24159970
100MAPK10.22012166

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.39713073
2Nicotine addiction_Homo sapiens_hsa050332.87111730
3Synaptic vesicle cycle_Homo sapiens_hsa047212.84188965
4Olfactory transduction_Homo sapiens_hsa047402.66612191
5Fatty acid biosynthesis_Homo sapiens_hsa000612.46786845
6Morphine addiction_Homo sapiens_hsa050322.41785638
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.41727275
8Circadian entrainment_Homo sapiens_hsa047132.37600805
9GABAergic synapse_Homo sapiens_hsa047272.12461874
10Long-term potentiation_Homo sapiens_hsa047202.12076667
11Glutamatergic synapse_Homo sapiens_hsa047242.06596628
12Insulin secretion_Homo sapiens_hsa049112.06382585
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00948319
14Gastric acid secretion_Homo sapiens_hsa049711.88772469
15Amphetamine addiction_Homo sapiens_hsa050311.87200044
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80680254
17Salivary secretion_Homo sapiens_hsa049701.75232870
18Cholinergic synapse_Homo sapiens_hsa047251.66651460
19Taste transduction_Homo sapiens_hsa047421.65998687
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55664907
21cAMP signaling pathway_Homo sapiens_hsa040241.55315502
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52446581
23Calcium signaling pathway_Homo sapiens_hsa040201.47435700
24Type II diabetes mellitus_Homo sapiens_hsa049301.42676182
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36606583
26Oxytocin signaling pathway_Homo sapiens_hsa049211.36193223
27Dorso-ventral axis formation_Homo sapiens_hsa043201.33855669
28Dopaminergic synapse_Homo sapiens_hsa047281.33636561
29Estrogen signaling pathway_Homo sapiens_hsa049151.33374008
30Cocaine addiction_Homo sapiens_hsa050301.32859542
31Renin secretion_Homo sapiens_hsa049241.28094189
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.23593022
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21392213
34Endocytosis_Homo sapiens_hsa041441.19964687
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12933615
36Type I diabetes mellitus_Homo sapiens_hsa049401.12525374
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10754248
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03400230
39VEGF signaling pathway_Homo sapiens_hsa043701.01786894
40Butanoate metabolism_Homo sapiens_hsa006500.97456555
41Graft-versus-host disease_Homo sapiens_hsa053320.96537406
42Allograft rejection_Homo sapiens_hsa053300.95353393
43Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95249958
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.93428260
45Autoimmune thyroid disease_Homo sapiens_hsa053200.91146672
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90064083
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89871378
48Cardiac muscle contraction_Homo sapiens_hsa042600.88904677
49Glioma_Homo sapiens_hsa052140.88414164
50MAPK signaling pathway_Homo sapiens_hsa040100.87515212
51Inositol phosphate metabolism_Homo sapiens_hsa005620.86880850
52Serotonergic synapse_Homo sapiens_hsa047260.86811198
53Phototransduction_Homo sapiens_hsa047440.85927066
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85644757
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84069045
56Long-term depression_Homo sapiens_hsa047300.82666259
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.81244747
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81232563
59Vitamin B6 metabolism_Homo sapiens_hsa007500.80545904
60Pancreatic secretion_Homo sapiens_hsa049720.79102153
61GnRH signaling pathway_Homo sapiens_hsa049120.76385706
62Melanogenesis_Homo sapiens_hsa049160.75749859
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75416961
64Bile secretion_Homo sapiens_hsa049760.74920644
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73703719
66Oocyte meiosis_Homo sapiens_hsa041140.72384990
67ErbB signaling pathway_Homo sapiens_hsa040120.70265486
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64729821
69Viral myocarditis_Homo sapiens_hsa054160.63125782
70Arginine and proline metabolism_Homo sapiens_hsa003300.62821315
71Antigen processing and presentation_Homo sapiens_hsa046120.62696577
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60686126
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.59029853
74Gap junction_Homo sapiens_hsa045400.58385799
75Choline metabolism in cancer_Homo sapiens_hsa052310.58292483
76Prion diseases_Homo sapiens_hsa050200.56368668
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56256227
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.56222399
79Thyroid hormone synthesis_Homo sapiens_hsa049180.55692235
80B cell receptor signaling pathway_Homo sapiens_hsa046620.54280945
81T cell receptor signaling pathway_Homo sapiens_hsa046600.53366072
82Chemokine signaling pathway_Homo sapiens_hsa040620.53092809
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50228605
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.48333411
85Collecting duct acid secretion_Homo sapiens_hsa049660.44909656
86Rap1 signaling pathway_Homo sapiens_hsa040150.43229046
87Ras signaling pathway_Homo sapiens_hsa040140.42214066
88Acute myeloid leukemia_Homo sapiens_hsa052210.41810324
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41710174
90Arginine biosynthesis_Homo sapiens_hsa002200.41519856
91Prolactin signaling pathway_Homo sapiens_hsa049170.40281333
92Axon guidance_Homo sapiens_hsa043600.39648859
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38951514
94Alcoholism_Homo sapiens_hsa050340.35242675
95Protein digestion and absorption_Homo sapiens_hsa049740.34876249
96Notch signaling pathway_Homo sapiens_hsa043300.34640129
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33854553
98Phenylalanine metabolism_Homo sapiens_hsa003600.33364319
99Osteoclast differentiation_Homo sapiens_hsa043800.33294698
100Non-small cell lung cancer_Homo sapiens_hsa052230.31122659

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