RTTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.69362278
2nuclear pore organization (GO:0006999)5.14797412
3protein localization to kinetochore (GO:0034501)4.95763601
4mitotic chromosome condensation (GO:0007076)4.92813394
5mitotic sister chromatid cohesion (GO:0007064)4.92250697
6kinetochore organization (GO:0051383)4.75128855
7sister chromatid segregation (GO:0000819)4.48135570
8pore complex assembly (GO:0046931)4.48093631
9protein localization to chromosome, centromeric region (GO:0071459)4.44552259
10mitotic metaphase plate congression (GO:0007080)4.40624838
11synapsis (GO:0007129)4.37272583
12mitotic sister chromatid segregation (GO:0000070)4.36324536
13metaphase plate congression (GO:0051310)4.13540045
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.11176827
15regulation of histone H3-K9 methylation (GO:0051570)4.03450543
16kinetochore assembly (GO:0051382)3.96833910
17negative regulation of histone methylation (GO:0031061)3.95356366
18CENP-A containing nucleosome assembly (GO:0034080)3.91798111
19chromatin remodeling at centromere (GO:0031055)3.90872851
20DNA unwinding involved in DNA replication (GO:0006268)3.88360570
21mitotic nuclear envelope disassembly (GO:0007077)3.87571445
22positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.87421845
23positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.87421845
24positive regulation of mitotic sister chromatid separation (GO:1901970)3.87421845
25establishment of chromosome localization (GO:0051303)3.86688697
26regulation of sister chromatid cohesion (GO:0007063)3.85737270
27negative regulation of DNA repair (GO:0045738)3.85151119
28double-strand break repair via nonhomologous end joining (GO:0006303)3.82435343
29non-recombinational repair (GO:0000726)3.82435343
30meiotic chromosome segregation (GO:0045132)3.78418034
31DNA replication-independent nucleosome organization (GO:0034724)3.78206495
32DNA replication-independent nucleosome assembly (GO:0006336)3.78206495
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.76301297
34attachment of spindle microtubules to kinetochore (GO:0008608)3.73398764
35DNA synthesis involved in DNA repair (GO:0000731)3.65634232
36histone-serine phosphorylation (GO:0035404)3.60515954
37membrane disassembly (GO:0030397)3.60179456
38nuclear envelope disassembly (GO:0051081)3.60179456
39positive regulation of chromosome segregation (GO:0051984)3.53842196
40regulation of mitotic spindle organization (GO:0060236)3.53645237
41regulation of centriole replication (GO:0046599)3.50455288
42histone exchange (GO:0043486)3.47142492
43regulation of spindle organization (GO:0090224)3.45251142
44chromatin assembly or disassembly (GO:0006333)3.43056506
45pre-miRNA processing (GO:0031054)3.40714276
46DNA replication-dependent nucleosome assembly (GO:0006335)3.40179581
47DNA replication-dependent nucleosome organization (GO:0034723)3.40179581
48regulation of DNA endoreduplication (GO:0032875)3.37216439
49protein localization to chromosome (GO:0034502)3.35910200
50DNA geometric change (GO:0032392)3.35640575
51replication fork processing (GO:0031297)3.35095576
52chromosome condensation (GO:0030261)3.34183593
53spindle checkpoint (GO:0031577)3.34023257
54DNA duplex unwinding (GO:0032508)3.33984923
55mitotic recombination (GO:0006312)3.33227722
56chromosome segregation (GO:0007059)3.32644602
57mitotic G2/M transition checkpoint (GO:0044818)3.27551342
58DNA replication initiation (GO:0006270)3.25648599
59regulation of chromosome segregation (GO:0051983)3.24061586
60regulation of meiosis I (GO:0060631)3.23330086
61telomere maintenance via recombination (GO:0000722)3.22142969
62DNA strand elongation involved in DNA replication (GO:0006271)3.18423739
63microtubule depolymerization (GO:0007019)3.15685066
64chromosome organization involved in meiosis (GO:0070192)3.14273655
65positive regulation of histone H3-K4 methylation (GO:0051571)3.13712383
66microtubule anchoring (GO:0034453)3.13675598
67regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13194206
68sister chromatid cohesion (GO:0007062)3.12560248
69regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11287510
70postreplication repair (GO:0006301)3.10613789
71DNA packaging (GO:0006323)3.10237455
72response to X-ray (GO:0010165)3.09670271
73protein K6-linked ubiquitination (GO:0085020)3.07768941
74DNA conformation change (GO:0071103)3.07190846
75DNA strand elongation (GO:0022616)3.06952420
76negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.06119171
77peptidyl-lysine dimethylation (GO:0018027)3.05302193
78regulation of mitotic sister chromatid separation (GO:0010965)3.02804692
79regulation of mitotic sister chromatid segregation (GO:0033047)3.02804692
80regulation of sister chromatid segregation (GO:0033045)3.02804692
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.01785350
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01785350
83spindle assembly checkpoint (GO:0071173)3.01781171
84regulation of centrosome cycle (GO:0046605)3.00287038
85gene silencing by RNA (GO:0031047)3.00230620
86regulation of RNA export from nucleus (GO:0046831)3.00019887
87DNA replication checkpoint (GO:0000076)2.97655757
88mitotic spindle checkpoint (GO:0071174)2.95816999
89ATP-dependent chromatin remodeling (GO:0043044)2.93744384
90DNA topological change (GO:0006265)2.93186848
91negative regulation of chromosome segregation (GO:0051985)2.92631543
92telomere maintenance via semi-conservative replication (GO:0032201)2.91949157
93positive regulation of DNA-dependent DNA replication (GO:2000105)2.91853510
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91331779
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91044077
96monoubiquitinated protein deubiquitination (GO:0035520)2.90856583
97regulation of histone H3-K27 methylation (GO:0061085)2.88427658
98regulation of nuclear cell cycle DNA replication (GO:0033262)2.88418814
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88184799
100negative regulation of sister chromatid segregation (GO:0033046)2.88184799
101negative regulation of mitotic sister chromatid separation (GO:2000816)2.88184799
102negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88184799
103mitotic spindle assembly checkpoint (GO:0007094)2.86642404
104negative regulation of DNA-dependent DNA replication (GO:2000104)2.85541622
105telomere maintenance (GO:0000723)2.78149376
106regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76566269
107chromatin assembly (GO:0031497)2.76281374
108mismatch repair (GO:0006298)2.75370619
109telomere organization (GO:0032200)2.74016450
110nuclear envelope organization (GO:0006998)2.73939444
111histone mRNA catabolic process (GO:0071044)2.73788354
112establishment of mitotic spindle localization (GO:0040001)2.72312147
113DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.70986189
114regulation of centrosome duplication (GO:0010824)2.68256266
115translesion synthesis (GO:0019985)2.68244331
116chromosome organization (GO:0051276)2.68042779
117centriole replication (GO:0007099)2.67136132
118nucleotide-excision repair, DNA gap filling (GO:0006297)2.66933336
119regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66098359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.52541717
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.89735677
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.80433856
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.18985399
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.98953929
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.88762393
7E2F1_21310950_ChIP-Seq_MCF-7_Human2.56706694
8AR_21909140_ChIP-Seq_LNCAP_Human2.48757723
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43722235
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.34356396
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26566383
12FUS_26573619_Chip-Seq_HEK293_Human2.19892958
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19397884
14GATA1_22025678_ChIP-Seq_K562_Human2.13478115
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.00745291
16E2F7_22180533_ChIP-Seq_HELA_Human12.0276145
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97232044
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87021084
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86798670
20MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75168369
21* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72192533
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71859801
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67413376
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67202608
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64272762
26MYC_22102868_ChIP-Seq_BL_Human1.61339814
27TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.59067728
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57361905
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56707049
30GBX2_23144817_ChIP-Seq_PC3_Human1.55393399
31ELK1_19687146_ChIP-ChIP_HELA_Human1.54081129
32TAF15_26573619_Chip-Seq_HEK293_Human1.51368075
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50577054
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49392351
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43842722
36* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34565414
37CIITA_25753668_ChIP-Seq_RAJI_Human1.33817050
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32033691
39IGF1R_20145208_ChIP-Seq_DFB_Human1.31460467
40* STAT3_23295773_ChIP-Seq_U87_Human1.29780584
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29329476
42* VDR_23849224_ChIP-Seq_CD4+_Human1.28349213
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26182156
44TP53_16413492_ChIP-PET_HCT116_Human1.25862406
45* EST1_17652178_ChIP-ChIP_JURKAT_Human1.22993886
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21711639
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.21214692
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20271866
49* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20260869
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19782166
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19674784
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19030353
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18668976
54* FOXP3_21729870_ChIP-Seq_TREG_Human1.18551580
55EWS_26573619_Chip-Seq_HEK293_Human1.17942136
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16748122
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.16206609
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.15802674
59* TCF4_23295773_ChIP-Seq_U87_Human1.14446675
60MYB_26560356_Chip-Seq_TH1_Human1.13536136
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12424502
62KDM5A_27292631_Chip-Seq_BREAST_Human1.12256460
63* TTF2_22483619_ChIP-Seq_HELA_Human1.11401710
64SMAD4_21799915_ChIP-Seq_A2780_Human1.11089834
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10404932
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09984912
67XRN2_22483619_ChIP-Seq_HELA_Human1.09931626
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09518394
69VDR_21846776_ChIP-Seq_THP-1_Human1.08860751
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08670604
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08458994
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07970237
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07962809
74MYB_26560356_Chip-Seq_TH2_Human1.07694569
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06303345
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05926986
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05618145
78P300_19829295_ChIP-Seq_ESCs_Human1.04749954
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.04013807
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03951213
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02880009
82SOX9_26525672_Chip-Seq_HEART_Mouse1.02579253
83SCL_19346495_ChIP-Seq_HPC-7_Human1.01374232
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01071269
85* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99714392
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99182895
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98818593
88TFEB_21752829_ChIP-Seq_HELA_Human0.98688593
89* SPI1_23547873_ChIP-Seq_NB4_Human0.98219485
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98037968
91FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97066500
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97015586
93MYC_18940864_ChIP-ChIP_HL60_Human0.96942163
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96916147
95CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95225795
96* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94703921
97PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92737791
98SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92426851
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92205945
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92040061
101NOTCH1_21737748_ChIP-Seq_TLL_Human0.91761106
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91274769
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90979626
104PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89162829
105SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88643325
106CREB1_15753290_ChIP-ChIP_HEK293T_Human0.88190015
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88029191
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87688182
109BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87037350
110GABP_17652178_ChIP-ChIP_JURKAT_Human0.86985420
111RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86930922
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86876355
113EZH2_27294783_Chip-Seq_NPCs_Mouse0.86502833
114WT1_19549856_ChIP-ChIP_CCG9911_Human0.86250710
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86240273
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86240273
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85837712
118* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85825913
119* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84831140
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.84327158
121E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84256539
122TCF7_22412390_ChIP-Seq_EML_Mouse0.84137383
123* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83945921
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.82943661
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81910041
126* DCP1A_22483619_ChIP-Seq_HELA_Human0.81827591
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81786317
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.80966166
129E2F1_18555785_Chip-Seq_ESCs_Mouse0.80922545
130* CBP_20019798_ChIP-Seq_JUKART_Human0.80907633
131* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80907633
132ZFX_18555785_ChIP-Seq_MESCs_Mouse0.80251341
133IRF1_19129219_ChIP-ChIP_H3396_Human0.77746712
134ER_23166858_ChIP-Seq_MCF-7_Human0.77326127
135NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77210181
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77067134
137IRF8_27001747_Chip-Seq_BMDM_Mouse0.76141523
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.75672627
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.74946266
140UTX_26944678_Chip-Seq_JUKART_Human0.74899898
141CTBP2_25329375_ChIP-Seq_LNCAP_Human0.73589940
142TOP2B_26459242_ChIP-Seq_MCF-7_Human0.72263084
143IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.71891687
144RUNX1_22412390_ChIP-Seq_EML_Mouse0.71259823
145KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71095402
146POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.70850126
147FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70834783
148POU5F1_16153702_ChIP-ChIP_HESCs_Human0.70815150
149ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.70634369
150* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.70514913
151BRD4_25478319_ChIP-Seq_HGPS_Human0.69682761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.26809491
2MP0000569_abnormal_digit_pigmentation4.12972317
3MP0008057_abnormal_DNA_replication3.91253519
4MP0003111_abnormal_nucleus_morphology3.75326269
5MP0003693_abnormal_embryo_hatching3.53500003
6MP0003077_abnormal_cell_cycle3.32401808
7MP0004957_abnormal_blastocyst_morpholog2.85479089
8MP0008877_abnormal_DNA_methylation2.48738908
9MP0008058_abnormal_DNA_repair2.44683631
10MP0002396_abnormal_hematopoietic_system2.44062436
11MP0010352_gastrointestinal_tract_polyps2.38167698
12MP0003121_genomic_imprinting2.30994731
13MP0010307_abnormal_tumor_latency2.29291513
14MP0003123_paternal_imprinting2.15171253
15MP0008007_abnormal_cellular_replicative2.08867000
16MP0003787_abnormal_imprinting1.99999285
17MP0001661_extended_life_span1.91672301
18MP0000350_abnormal_cell_proliferation1.89679292
19MP0005076_abnormal_cell_differentiation1.85519040
20MP0008932_abnormal_embryonic_tissue1.84933293
21MP0004808_abnormal_hematopoietic_stem1.76613340
22MP0001730_embryonic_growth_arrest1.64628102
23MP0001672_abnormal_embryogenesis/_devel1.59542031
24MP0005380_embryogenesis_phenotype1.59542031
25MP0000372_irregular_coat_pigmentation1.57039042
26MP0003763_abnormal_thymus_physiology1.56660413
27MP0005174_abnormal_tail_pigmentation1.55507493
28MP0002006_tumorigenesis1.54678981
29MP0000427_abnormal_hair_cycle1.54590431
30MP0003941_abnormal_skin_development1.53380402
31MP0005171_absent_coat_pigmentation1.49864865
32MP0009278_abnormal_bone_marrow1.48762991
33MP0002166_altered_tumor_susceptibility1.48451714
34MP0003890_abnormal_embryonic-extraembry1.41027909
35MP0003984_embryonic_growth_retardation1.37311892
36MP0002088_abnormal_embryonic_growth/wei1.36063814
37MP0000490_abnormal_crypts_of1.35758063
38MP0003718_maternal_effect1.34715662
39MP0002009_preneoplasia1.34295187
40* MP0001697_abnormal_embryo_size1.32741850
41MP0002086_abnormal_extraembryonic_tissu1.32295967
42MP0000703_abnormal_thymus_morphology1.32203883
43* MP0002085_abnormal_embryonic_tissue1.32090460
44MP0005397_hematopoietic_system_phenotyp1.26785066
45MP0001545_abnormal_hematopoietic_system1.26785066
46MP0001915_intracranial_hemorrhage1.26283647
47MP0002398_abnormal_bone_marrow1.26192942
48MP0004197_abnormal_fetal_growth/weight/1.25815660
49* MP0002084_abnormal_developmental_patter1.25067663
50MP0002019_abnormal_tumor_incidence1.23861302
51MP0003950_abnormal_plasma_membrane1.20857252
52MP0010234_abnormal_vibrissa_follicle1.18393345
53MP0000015_abnormal_ear_pigmentation1.15580084
54MP0001800_abnormal_humoral_immune1.15030492
55* MP0002080_prenatal_lethality1.13988800
56MP0000383_abnormal_hair_follicle1.13873521
57MP0000579_abnormal_nail_morphology1.13265429
58MP0002210_abnormal_sex_determination1.11994240
59MP0000689_abnormal_spleen_morphology1.10876267
60MP0000313_abnormal_cell_death1.10477613
61MP0002722_abnormal_immune_system1.07337632
62MP0001293_anophthalmia1.07190405
63MP0003786_premature_aging1.06809678
64MP0001929_abnormal_gametogenesis1.06452049
65MP0005395_other_phenotype1.05136801
66MP0001835_abnormal_antigen_presentation1.04241449
67MP0003937_abnormal_limbs/digits/tail_de1.04035071
68MP0001119_abnormal_female_reproductive1.03846948
69MP0000428_abnormal_craniofacial_morphol1.03239321
70MP0004381_abnormal_hair_follicle1.03074405
71MP0000733_abnormal_muscle_development1.02564630
72MP0002452_abnormal_antigen_presenting1.00869335
73MP0003646_muscle_fatigue1.00679093
74MP0002269_muscular_atrophy1.00251727
75MP0002234_abnormal_pharynx_morphology0.99967272
76MP0002233_abnormal_nose_morphology0.99755018
77MP0003567_abnormal_fetal_cardiomyocyte0.98735990
78MP0000371_diluted_coat_color0.97414932
79MP0003943_abnormal_hepatobiliary_system0.96622076
80MP0001299_abnormal_eye_distance/0.95696827
81MP0003136_yellow_coat_color0.93354548
82MP0002095_abnormal_skin_pigmentation0.92537963
83MP0003566_abnormal_cell_adhesion0.91954089
84MP0003300_gastrointestinal_ulcer0.91514402
85MP0003705_abnormal_hypodermis_morpholog0.91186922
86MP0005621_abnormal_cell_physiology0.90347043
87MP0002420_abnormal_adaptive_immunity0.89130393
88MP0002697_abnormal_eye_size0.88554974
89MP0000653_abnormal_sex_gland0.88432325
90MP0002075_abnormal_coat/hair_pigmentati0.88267623
91MP0000716_abnormal_immune_system0.88125844
92MP0002938_white_spotting0.87918242
93MP0001819_abnormal_immune_cell0.87716177
94MP0006054_spinal_hemorrhage0.85803851
95MP0000465_gastrointestinal_hemorrhage0.85789879
96MP0002429_abnormal_blood_cell0.84768488
97MP0003935_abnormal_craniofacial_develop0.84578948
98MP0001145_abnormal_male_reproductive0.84159648
99MP0005408_hypopigmentation0.84036442
100MP0005075_abnormal_melanosome_morpholog0.83730422
101MP0002160_abnormal_reproductive_system0.83282978
102MP0000358_abnormal_cell_content/0.82816376
103MP0000432_abnormal_head_morphology0.82087048
104MP0009703_decreased_birth_body0.82053847
105MP0010678_abnormal_skin_adnexa0.80980356
106MP0005409_darkened_coat_color0.80183640
107MP0002723_abnormal_immune_serum0.79175853
108MP0005384_cellular_phenotype0.77582522
109MP0003755_abnormal_palate_morphology0.77356594
110MP0002405_respiratory_system_inflammati0.76451132
111MP0005023_abnormal_wound_healing0.75839930
112MP0005671_abnormal_response_to0.75776980
113MP0001873_stomach_inflammation0.75508635
114MP0003699_abnormal_female_reproductive0.75123215
115MP0010030_abnormal_orbit_morphology0.74347962
116MP0009697_abnormal_copulation0.74130475
117* MP0002925_abnormal_cardiovascular_devel0.74061936
118MP0000685_abnormal_immune_system0.73199309
119MP0003448_altered_tumor_morphology0.73179936
120MP0003698_abnormal_male_reproductive0.72833350
121MP0000377_abnormal_hair_follicle0.71787294
122MP0009672_abnormal_birth_weight0.70492215
123MP0003385_abnormal_body_wall0.70371742
124MP0001286_abnormal_eye_development0.70051990
125MP0004264_abnormal_extraembryonic_tissu0.69654322
126MP0003091_abnormal_cell_migration0.69324283
127MP0002092_abnormal_eye_morphology0.68181000
128MP0001186_pigmentation_phenotype0.67021847
129MP0000762_abnormal_tongue_morphology0.65675137
130MP0005187_abnormal_penis_morphology0.65318879
131MP0009053_abnormal_anal_canal0.65057888
132MP0000647_abnormal_sebaceous_gland0.64419152

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.86608034
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.66949394
3Abnormality of the fingertips (HP:0001211)3.94732495
4Ectopic kidney (HP:0000086)3.51067555
5Volvulus (HP:0002580)3.39968495
6Abnormality of chromosome stability (HP:0003220)3.34467644
7Impulsivity (HP:0100710)3.21362140
8Short 4th metacarpal (HP:0010044)2.91772468
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.91772468
10Meckel diverticulum (HP:0002245)2.80794978
11Aplasia/Hypoplasia of the uvula (HP:0010293)2.73587352
12Myelodysplasia (HP:0002863)2.69601155
13Birth length less than 3rd percentile (HP:0003561)2.63595045
14Abnormality of the ileum (HP:0001549)2.60718594
15Increased nuchal translucency (HP:0010880)2.58536639
16Abnormality of the preputium (HP:0100587)2.56618303
17Duodenal stenosis (HP:0100867)2.55913806
18Small intestinal stenosis (HP:0012848)2.55913806
19Medulloblastoma (HP:0002885)2.53266147
20Acute myeloid leukemia (HP:0004808)2.51832158
21Nephroblastoma (Wilms tumor) (HP:0002667)2.50675264
22Duplicated collecting system (HP:0000081)2.49193124
23Reticulocytopenia (HP:0001896)2.48648498
24Hypoplastic labia majora (HP:0000059)2.42271312
25Prominent nose (HP:0000448)2.42211454
26Chronic hepatic failure (HP:0100626)2.40032040
27Papillary thyroid carcinoma (HP:0002895)2.37753506
28Abnormal auditory evoked potentials (HP:0006958)2.32917615
29Embryonal renal neoplasm (HP:0011794)2.32102297
30Abnormality of the renal collecting system (HP:0004742)2.31280182
31Long eyelashes (HP:0000527)2.30352310
32Vertebral arch anomaly (HP:0008438)2.30126575
33Selective tooth agenesis (HP:0001592)2.29790534
34Rhabdomyosarcoma (HP:0002859)2.29210824
35Colon cancer (HP:0003003)2.28401774
36Abnormality of the labia majora (HP:0012881)2.26663477
37Deviation of the thumb (HP:0009603)2.26138130
38Abnormality of the carotid arteries (HP:0005344)2.24634978
39Sloping forehead (HP:0000340)2.23029207
40Abnormality of the labia minora (HP:0012880)2.21418780
41Cafe-au-lait spot (HP:0000957)2.20273745
42Patellar aplasia (HP:0006443)2.19048271
43Abnormal lung lobation (HP:0002101)2.18608100
44Absent frontal sinuses (HP:0002688)2.16577292
45Tubulointerstitial nephritis (HP:0001970)2.16094038
46Proximal placement of thumb (HP:0009623)2.15470336
47Clubbing of toes (HP:0100760)2.13778092
48Abnormality of the duodenum (HP:0002246)2.13002130
49Aplasia/Hypoplasia of the sternum (HP:0006714)2.09717983
50Agnosia (HP:0010524)2.09517681
51Absent radius (HP:0003974)2.08530520
52Ependymoma (HP:0002888)2.04305471
53Milia (HP:0001056)2.04249982
54Poikiloderma (HP:0001029)2.03736596
55Microglossia (HP:0000171)2.01628225
56Prostate neoplasm (HP:0100787)2.01439167
57Deep philtrum (HP:0002002)2.01390060
58Aplasia/Hypoplasia of the patella (HP:0006498)2.00775631
59Fair hair (HP:0002286)2.00636714
60Biliary tract neoplasm (HP:0100574)2.00342244
61High pitched voice (HP:0001620)2.00288844
62Embryonal neoplasm (HP:0002898)1.99563270
63IgA deficiency (HP:0002720)1.99013886
64Sandal gap (HP:0001852)1.97512473
65Gastrointestinal atresia (HP:0002589)1.97001678
66Short thumb (HP:0009778)1.96895053
67Skull defect (HP:0001362)1.94202898
68Absent forearm bone (HP:0003953)1.94071793
69Aplasia involving forearm bones (HP:0009822)1.94071793
70Anal stenosis (HP:0002025)1.91883319
71Arteriovenous malformation (HP:0100026)1.90618403
72Neoplasm of the small intestine (HP:0100833)1.90356438
73Urethral obstruction (HP:0000796)1.90295965
74Thyroiditis (HP:0100646)1.89253026
75Neoplasm of striated muscle (HP:0009728)1.89056478
76Choanal atresia (HP:0000453)1.89002420
77Bifid tongue (HP:0010297)1.88475726
78Thyroid carcinoma (HP:0002890)1.88462469
79Abnormality of DNA repair (HP:0003254)1.88108952
80Aplasia/Hypoplasia of the earlobes (HP:0009906)1.87053623
81Abnormality of the 4th metacarpal (HP:0010012)1.86667129
82Neoplasm of the oral cavity (HP:0100649)1.85224718
83High anterior hairline (HP:0009890)1.85212515
84Absent thumb (HP:0009777)1.84998476
85Large earlobe (HP:0009748)1.84980568
86Bone marrow hypocellularity (HP:0005528)1.84462901
87Facial hemangioma (HP:0000329)1.84264194
88Neoplasm of the colon (HP:0100273)1.83875056
89Truncal obesity (HP:0001956)1.81499451
90Short chin (HP:0000331)1.81160525
91Recurrent viral infections (HP:0004429)1.80999478
92Leiomyosarcoma (HP:0100243)1.80074587
93Uterine leiomyosarcoma (HP:0002891)1.80074587
94Transitional cell carcinoma of the bladder (HP:0006740)1.79882614
95Capillary hemangiomas (HP:0005306)1.79314041
96Hypopigmentation of the fundus (HP:0007894)1.77471194
97Amaurosis fugax (HP:0100576)1.77067684
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.76838072
99Cutis marmorata (HP:0000965)1.76671112
100Triphalangeal thumb (HP:0001199)1.75902715
101Leukopenia (HP:0001882)1.75884436
102Lip pit (HP:0100267)1.75348507
103Combined immunodeficiency (HP:0005387)1.74950110
104Astrocytoma (HP:0009592)1.74706082
105Abnormality of the astrocytes (HP:0100707)1.74706082
106T lymphocytopenia (HP:0005403)1.74435203
107Neoplasm of the adrenal cortex (HP:0100641)1.74380078
108Low anterior hairline (HP:0000294)1.73651636
109Bladder carcinoma (HP:0002862)1.73584117
110Bladder neoplasm (HP:0009725)1.73584117
111Syringomyelia (HP:0003396)1.72080532
112Spinal cord lesions (HP:0100561)1.72080532
113Heterotopia (HP:0002282)1.72074831
114Oligodactyly (hands) (HP:0001180)1.69603601
115Obsessive-compulsive behavior (HP:0000722)1.66440224
116Small hand (HP:0200055)1.65867948
117Abnormality of T cell number (HP:0011839)1.65645223
118Oligodactyly (HP:0012165)1.65454629
119Premature graying of hair (HP:0002216)1.64316943
120Esophageal atresia (HP:0002032)1.64263090
121Freckling (HP:0001480)1.63633811
122Abnormal biliary tract morphology (HP:0012440)1.63249712
123Abnormal foot bone ossification (HP:0010675)1.63111261
124Abnormality of chromosome segregation (HP:0002916)1.62617274
125Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61768237
126Overlapping toe (HP:0001845)1.61757481
127Long clavicles (HP:0000890)1.61544258
128Basal cell carcinoma (HP:0002671)1.61483789
129Ovarian neoplasm (HP:0100615)1.60837176
130Aqueductal stenosis (HP:0002410)1.60727259
131Optic neuritis (HP:0100653)1.60002382
132Retrobulbar optic neuritis (HP:0100654)1.60002382
133Malignant gastrointestinal tract tumors (HP:0006749)1.59910705
134Gastrointestinal carcinoma (HP:0002672)1.59910705
135Abnormality of the columella (HP:0009929)1.59580386
136Lymphoma (HP:0002665)1.59529474
137Glioma (HP:0009733)1.58524928
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.57456573
139Microtia (HP:0008551)1.57335971
140Tracheoesophageal fistula (HP:0002575)1.57257092
141Narrow palate (HP:0000189)1.56692495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.27989393
2CDK123.63439786
3PNCK2.91880892
4TTK2.91201112
5NEK22.65077140
6TAF12.30638176
7SRPK12.23952288
8PLK42.22504582
9BMPR1B2.21996004
10STK102.20719093
11LATS12.19638857
12ATR2.14797309
13EEF2K2.00953915
14CHEK22.00013390
15STK31.87745725
16PBK1.83710981
17AURKB1.81622091
18BUB11.79829906
19MET1.77710789
20MELK1.75939844
21PASK1.75427703
22PLK11.74283208
23STK41.67161916
24WEE11.66137051
25CHEK11.59751726
26BRD41.57186756
27TLK11.52433351
28MKNK11.51258195
29NUAK11.50869671
30ZAK1.42947451
31ATM1.42540167
32PLK31.40760011
33CDK41.34562254
34CDK61.32381366
35BRSK21.32364075
36TNIK1.32027005
37TAOK31.28596302
38MAP3K81.27862050
39MKNK21.23892165
40CDK91.22119413
41RPS6KB21.21814589
42NEK91.19986208
43TTN1.16937967
44CDK71.14613477
45MAP4K11.13251805
46JAK31.09243020
47RPS6KA41.08014735
48KIT1.07847180
49STK391.07312119
50PIM11.06839352
51VRK11.05794617
52BRSK11.05284732
53CLK11.05007517
54MAP3K61.04987057
55MAP3K101.04159932
56MST1R1.01141340
57CDK20.97554709
58STK38L0.95989888
59CAMK1D0.95433312
60TRPM70.95289195
61FGFR20.94268614
62MAP3K140.92159193
63TYK20.89332914
64MST40.89257185
65CDK10.86614853
66MTOR0.84811016
67CHUK0.84160199
68CCNB10.83438888
69TGFBR10.82562641
70TESK20.80586775
71ACVR1B0.80575823
72EIF2AK10.79338610
73PIK3CG0.76699619
74YES10.73043760
75DYRK30.71973991
76ERBB30.71414430
77FGFR10.70938518
78EIF2AK20.69590224
79NTRK20.69530603
80CSF1R0.68115695
81ITK0.66711496
82TEC0.66121376
83PLK20.65938430
84ALK0.65883941
85WNK10.63227344
86PRKDC0.59754924
87CSNK1D0.59075770
88AKT10.58322551
89NEK60.56690165
90CAMK1G0.56446696
91FGFR30.55423022
92TSSK60.54901998
93PTK60.53785681
94TXK0.53257822
95RPS6KA50.52681037
96NLK0.52426375
97WNK30.52160626
98MAPK140.51886164
99LRRK20.51623781
100MARK30.51120818
101AURKA0.50823375
102SCYL20.50294168
103IKBKB0.50171058
104AKT30.49912275
105MAPK10.49244733
106HCK0.48313514
107LCK0.47917938
108SIK20.47334108
109FLT30.46936459
110MAPK110.46900583
111CDK30.46806174
112MAP3K130.44533114
113TGFBR20.42204729
114BTK0.40431270
115FRK0.39818152
116MAP3K40.38971101
117KSR10.38815763
118BRAF0.37345203
119CDK80.37037930
120CSNK2A20.36294057
121PRKAA20.35625451
122IKBKE0.35239803
123NEK10.35204236
124GSK3B0.34458771
125STK240.34017812
126RPS6KB10.33912411
127MAP3K90.33180028
128SGK20.32444375
129PDGFRB0.32418076
130CSNK1G10.32408975
131CSNK1A1L0.32109881
132EIF2AK30.31943141
133MAP3K20.31563809
134OBSCN0.31536269
135PDGFRA0.29926619

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.60279476
2Mismatch repair_Homo sapiens_hsa034303.41956998
3Cell cycle_Homo sapiens_hsa041103.13458946
4Non-homologous end-joining_Homo sapiens_hsa034502.98108990
5Homologous recombination_Homo sapiens_hsa034402.95020830
6Fanconi anemia pathway_Homo sapiens_hsa034602.80800052
7One carbon pool by folate_Homo sapiens_hsa006702.54593655
8Base excision repair_Homo sapiens_hsa034102.54470089
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39862407
10RNA transport_Homo sapiens_hsa030132.38953035
11Spliceosome_Homo sapiens_hsa030402.22472922
12Nucleotide excision repair_Homo sapiens_hsa034201.98563803
13RNA degradation_Homo sapiens_hsa030181.96160334
14p53 signaling pathway_Homo sapiens_hsa041151.81342654
15Systemic lupus erythematosus_Homo sapiens_hsa053221.80380075
16Basal transcription factors_Homo sapiens_hsa030221.72986094
17mRNA surveillance pathway_Homo sapiens_hsa030151.72392078
18MicroRNAs in cancer_Homo sapiens_hsa052061.69782274
19Herpes simplex infection_Homo sapiens_hsa051681.47308957
20Small cell lung cancer_Homo sapiens_hsa052221.42934929
21Viral carcinogenesis_Homo sapiens_hsa052031.41595597
22RNA polymerase_Homo sapiens_hsa030201.38892815
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.37674799
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34923426
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.32656038
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29834335
27Lysine degradation_Homo sapiens_hsa003101.27676794
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27164000
29Primary immunodeficiency_Homo sapiens_hsa053401.26482170
30Selenocompound metabolism_Homo sapiens_hsa004501.21451567
31HTLV-I infection_Homo sapiens_hsa051661.20815288
32Chronic myeloid leukemia_Homo sapiens_hsa052201.19984033
33Measles_Homo sapiens_hsa051621.14477030
34Pyrimidine metabolism_Homo sapiens_hsa002401.13978197
35Epstein-Barr virus infection_Homo sapiens_hsa051691.13950763
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12083071
37Antigen processing and presentation_Homo sapiens_hsa046121.11692370
38Notch signaling pathway_Homo sapiens_hsa043301.09170694
39Pancreatic cancer_Homo sapiens_hsa052121.04693033
40Hepatitis B_Homo sapiens_hsa051611.02434624
41B cell receptor signaling pathway_Homo sapiens_hsa046620.97938538
42TGF-beta signaling pathway_Homo sapiens_hsa043500.96905708
43Adherens junction_Homo sapiens_hsa045200.95455689
44Oocyte meiosis_Homo sapiens_hsa041140.94754826
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89507655
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.89433263
47Colorectal cancer_Homo sapiens_hsa052100.88450362
48Apoptosis_Homo sapiens_hsa042100.88047319
49Influenza A_Homo sapiens_hsa051640.86957479
50Non-small cell lung cancer_Homo sapiens_hsa052230.86732277
51Glioma_Homo sapiens_hsa052140.85882488
52Prostate cancer_Homo sapiens_hsa052150.83751360
53Viral myocarditis_Homo sapiens_hsa054160.83391068
54Hematopoietic cell lineage_Homo sapiens_hsa046400.82762236
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80901960
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79683191
57Circadian rhythm_Homo sapiens_hsa047100.77398705
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77382326
59T cell receptor signaling pathway_Homo sapiens_hsa046600.75132433
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75095761
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.73153505
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69984300
63mTOR signaling pathway_Homo sapiens_hsa041500.68446084
64Pathways in cancer_Homo sapiens_hsa052000.66761163
65FoxO signaling pathway_Homo sapiens_hsa040680.66193370
66Osteoclast differentiation_Homo sapiens_hsa043800.65775769
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65746033
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.65594808
69Purine metabolism_Homo sapiens_hsa002300.65301428
70Toxoplasmosis_Homo sapiens_hsa051450.65044120
71Ribosome_Homo sapiens_hsa030100.62993976
72Leishmaniasis_Homo sapiens_hsa051400.62861431
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62518472
74Hedgehog signaling pathway_Homo sapiens_hsa043400.61802756
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61074908
76ErbB signaling pathway_Homo sapiens_hsa040120.58656972
77Propanoate metabolism_Homo sapiens_hsa006400.58619773
78Basal cell carcinoma_Homo sapiens_hsa052170.58542508
79Alcoholism_Homo sapiens_hsa050340.58018259
80Allograft rejection_Homo sapiens_hsa053300.57886121
81Thyroid cancer_Homo sapiens_hsa052160.57405496
82ECM-receptor interaction_Homo sapiens_hsa045120.56472304
83Endometrial cancer_Homo sapiens_hsa052130.55945210
84Proteoglycans in cancer_Homo sapiens_hsa052050.55795253
85Acute myeloid leukemia_Homo sapiens_hsa052210.55704568
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55220491
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.54974526
88TNF signaling pathway_Homo sapiens_hsa046680.54869710
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54570775
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52874198
91N-Glycan biosynthesis_Homo sapiens_hsa005100.51585318
92HIF-1 signaling pathway_Homo sapiens_hsa040660.50908888
93Graft-versus-host disease_Homo sapiens_hsa053320.50540936
94Hippo signaling pathway_Homo sapiens_hsa043900.50109705
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49370316
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47639639
97Legionellosis_Homo sapiens_hsa051340.47486802
98Shigellosis_Homo sapiens_hsa051310.46502858
99Melanoma_Homo sapiens_hsa052180.46131846
100Wnt signaling pathway_Homo sapiens_hsa043100.46131151
101Fatty acid biosynthesis_Homo sapiens_hsa000610.45943571
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44526175
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.43184387
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42933993
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42750760
106Malaria_Homo sapiens_hsa051440.42269714
107Renal cell carcinoma_Homo sapiens_hsa052110.41878478
108Inositol phosphate metabolism_Homo sapiens_hsa005620.41597467
109Autoimmune thyroid disease_Homo sapiens_hsa053200.40379074
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39429427
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38766210
112Platelet activation_Homo sapiens_hsa046110.36496772
113Chemokine signaling pathway_Homo sapiens_hsa040620.36272155
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35334420
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34702481
116Focal adhesion_Homo sapiens_hsa045100.34258850
117Dorso-ventral axis formation_Homo sapiens_hsa043200.34237989
118Prolactin signaling pathway_Homo sapiens_hsa049170.34117621
119Pyruvate metabolism_Homo sapiens_hsa006200.33807946
120Steroid biosynthesis_Homo sapiens_hsa001000.30851906
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27832276
122ABC transporters_Homo sapiens_hsa020100.25849729
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25248303
124Gap junction_Homo sapiens_hsa045400.24868737
125Choline metabolism in cancer_Homo sapiens_hsa052310.24706181
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23621951
127Sphingolipid metabolism_Homo sapiens_hsa006000.21453022
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.20937699
129Tight junction_Homo sapiens_hsa045300.20217066
130Glucagon signaling pathway_Homo sapiens_hsa049220.18626820
131Estrogen signaling pathway_Homo sapiens_hsa049150.17408736
132Taste transduction_Homo sapiens_hsa047420.16574876
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.16285450

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