RUFY3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.27972674
2neuron cell-cell adhesion (GO:0007158)4.97138427
3synaptic vesicle exocytosis (GO:0016079)4.89847561
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.77531584
5synaptic vesicle maturation (GO:0016188)4.73744228
6vocalization behavior (GO:0071625)4.71866713
7regulation of synaptic vesicle exocytosis (GO:2000300)4.61888295
8protein localization to synapse (GO:0035418)4.60427658
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.55924439
10glutamate secretion (GO:0014047)4.52500104
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.47002566
12locomotory exploration behavior (GO:0035641)4.29971576
13regulation of glutamate receptor signaling pathway (GO:1900449)4.18756417
14neurotransmitter secretion (GO:0007269)4.05671506
15cell migration in hindbrain (GO:0021535)4.04527083
16regulation of synaptic vesicle transport (GO:1902803)4.02092910
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.02070703
18neuronal action potential propagation (GO:0019227)4.01695383
19neuron recognition (GO:0008038)4.00555467
20pyrimidine nucleobase catabolic process (GO:0006208)3.97759437
21layer formation in cerebral cortex (GO:0021819)3.97691683
22synaptic vesicle docking involved in exocytosis (GO:0016081)3.83331527
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.82148614
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.73882045
25exploration behavior (GO:0035640)3.73652790
26glutamate receptor signaling pathway (GO:0007215)3.69593817
27synaptic transmission, glutamatergic (GO:0035249)3.65456835
28axonal fasciculation (GO:0007413)3.63222997
29neuron-neuron synaptic transmission (GO:0007270)3.62343666
30dendrite morphogenesis (GO:0048813)3.60242409
31presynaptic membrane assembly (GO:0097105)3.59197180
32gamma-aminobutyric acid transport (GO:0015812)3.59149936
33neurotransmitter-gated ion channel clustering (GO:0072578)3.57066219
34dendritic spine morphogenesis (GO:0060997)3.56055777
35proline transport (GO:0015824)3.53872734
36mechanosensory behavior (GO:0007638)3.53586424
37regulation of neuronal synaptic plasticity (GO:0048168)3.51504140
38regulation of synapse structural plasticity (GO:0051823)3.50757471
39neurotransmitter transport (GO:0006836)3.44401670
40cerebellar Purkinje cell differentiation (GO:0021702)3.40945906
41presynaptic membrane organization (GO:0097090)3.40778368
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36738487
43postsynaptic membrane organization (GO:0001941)3.36604569
44transmission of nerve impulse (GO:0019226)3.33426792
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33163746
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.31916633
47nucleobase catabolic process (GO:0046113)3.29533220
48negative regulation of microtubule polymerization (GO:0031115)3.23952355
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23135817
50synaptic vesicle endocytosis (GO:0048488)3.23036587
51central nervous system neuron axonogenesis (GO:0021955)3.20849089
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19527788
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17663864
54regulation of neurotransmitter secretion (GO:0046928)3.17107474
55positive regulation of membrane potential (GO:0045838)3.16573731
56regulation of postsynaptic membrane potential (GO:0060078)3.15625595
57synapse assembly (GO:0007416)3.14498419
58establishment of mitochondrion localization (GO:0051654)3.13582277
59retinal ganglion cell axon guidance (GO:0031290)3.13563141
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12879492
61neurofilament cytoskeleton organization (GO:0060052)3.12671901
62membrane depolarization during action potential (GO:0086010)3.11785652
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10831225
64cerebral cortex radially oriented cell migration (GO:0021799)3.10159030
65regulation of neurotransmitter levels (GO:0001505)3.09905129
66gamma-aminobutyric acid signaling pathway (GO:0007214)3.08712943
67activation of protein kinase A activity (GO:0034199)3.07934202
68long-term memory (GO:0007616)3.03049217
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.02471793
70positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.01547915
71membrane hyperpolarization (GO:0060081)3.01101292
72innervation (GO:0060384)3.00656643
73calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.00648556
74regulation of vesicle fusion (GO:0031338)3.00171465
75positive regulation of dendritic spine morphogenesis (GO:0061003)2.98824805
76cerebellar granule cell differentiation (GO:0021707)2.96354693
77mating behavior (GO:0007617)2.95441381
78organelle transport along microtubule (GO:0072384)2.94966676
79behavioral response to nicotine (GO:0035095)2.94601172
80auditory behavior (GO:0031223)2.93648405
81membrane depolarization (GO:0051899)2.92724021
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92559586
83regulation of neurotransmitter transport (GO:0051588)2.91711847
84response to auditory stimulus (GO:0010996)2.91196397
85axon extension (GO:0048675)2.89850268
86adult walking behavior (GO:0007628)2.89749311
87prepulse inhibition (GO:0060134)2.88363139
88positive regulation of synapse assembly (GO:0051965)2.87997894
89cellular potassium ion homeostasis (GO:0030007)2.87493601
90negative regulation of dendrite development (GO:2000171)2.87447241
91establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85899761
92mitochondrion transport along microtubule (GO:0047497)2.85899761
93long-term synaptic potentiation (GO:0060291)2.85332039
94central nervous system projection neuron axonogenesis (GO:0021952)2.85298584
95regulation of synapse assembly (GO:0051963)2.85240075
96regulation of synaptic plasticity (GO:0048167)2.84987500
97response to pheromone (GO:0019236)2.84950882
98negative regulation of dendrite morphogenesis (GO:0050774)2.84687715
99neuromuscular synaptic transmission (GO:0007274)2.84330869
100glycosphingolipid biosynthetic process (GO:0006688)2.84269514
101negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83704612
102regulation of dendritic spine morphogenesis (GO:0061001)2.82638810
103neuronal ion channel clustering (GO:0045161)2.82194552
104positive regulation of synapse maturation (GO:0090129)2.81099169
105axon ensheathment in central nervous system (GO:0032291)2.80946150
106central nervous system myelination (GO:0022010)2.80946150
107axon cargo transport (GO:0008088)2.80337857
108vesicle transport along microtubule (GO:0047496)2.80323297
109positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78674862
110synapse organization (GO:0050808)2.78584253
111dendrite development (GO:0016358)2.77976014
112axonogenesis (GO:0007409)2.77657511
113regulation of respiratory system process (GO:0044065)2.77474464
114limb bud formation (GO:0060174)2.77253418
115synaptic transmission (GO:0007268)2.76977778
116startle response (GO:0001964)2.76831200
117behavioral response to cocaine (GO:0048148)2.76709623
118neuromuscular process controlling posture (GO:0050884)2.76490807
119negative regulation of axon extension (GO:0030517)2.75084464
120protein localization to cilium (GO:0061512)2.71650261
121spinal cord development (GO:0021510)2.69388879
122adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.67361323
123regulation of axon guidance (GO:1902667)2.66906381
124establishment of nucleus localization (GO:0040023)2.64808042
125positive regulation of dendritic spine development (GO:0060999)2.64595532
126dendritic spine organization (GO:0097061)2.64361281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.54150465
2GBX2_23144817_ChIP-Seq_PC3_Human3.84055986
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93343140
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83274624
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77343886
6REST_21632747_ChIP-Seq_MESCs_Mouse2.62941217
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.48839825
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47608811
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45841065
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45841065
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44008097
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37878844
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36102241
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34777593
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31260372
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30648313
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28138952
18TAF15_26573619_Chip-Seq_HEK293_Human2.24316732
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20261388
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.16536857
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13901323
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.13644367
23DROSHA_22980978_ChIP-Seq_HELA_Human2.11810156
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.10057306
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03852384
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.02361202
27RARB_27405468_Chip-Seq_BRAIN_Mouse2.00453715
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97068311
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81727216
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79060131
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77516868
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73595576
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71051332
34AR_21572438_ChIP-Seq_LNCaP_Human1.71016580
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.69179432
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68576263
37IGF1R_20145208_ChIP-Seq_DFB_Human1.66326184
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62239831
39P300_19829295_ChIP-Seq_ESCs_Human1.60138737
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.54738676
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52288475
42ZNF274_21170338_ChIP-Seq_K562_Hela1.46707342
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43338257
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42565281
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42226426
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41380462
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40828576
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40718752
49RNF2_27304074_Chip-Seq_NSC_Mouse1.40033473
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39681228
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.39579728
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38023647
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34591383
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34031234
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.33992438
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.33885612
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31716763
58EWS_26573619_Chip-Seq_HEK293_Human1.30244383
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.29465591
60AR_25329375_ChIP-Seq_VCAP_Human1.29160517
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28574765
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28343921
63STAT3_23295773_ChIP-Seq_U87_Human1.28249288
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22187470
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21692457
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21597691
67VDR_22108803_ChIP-Seq_LS180_Human1.21481294
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.20475503
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18945412
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.15273721
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15076498
72AHR_22903824_ChIP-Seq_MCF-7_Human1.13958898
73AR_19668381_ChIP-Seq_PC3_Human1.13262063
74CBP_20019798_ChIP-Seq_JUKART_Human1.12818469
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12818469
76TCF4_23295773_ChIP-Seq_U87_Human1.12797886
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12578238
78ER_23166858_ChIP-Seq_MCF-7_Human1.11796072
79* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10796156
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10213019
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.10054668
82RUNX2_22187159_ChIP-Seq_PCA_Human1.09932616
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07564684
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07564684
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07127752
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.07076175
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06778998
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06496434
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05599631
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05328984
91FUS_26573619_Chip-Seq_HEK293_Human1.04843495
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04542823
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04409089
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03571290
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02303596
96* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01434406
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.01363686
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.00743181
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.00117346
100WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99428514
101SOX9_26525672_Chip-Seq_HEART_Mouse0.99205615
102P53_22387025_ChIP-Seq_ESCs_Mouse0.99047314
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.97886582
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97278390
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97118408
106JUN_21703547_ChIP-Seq_K562_Human0.95720024
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.92253860
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.90827300
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89977639
110KDM2B_26808549_Chip-Seq_REH_Human0.88432722
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86389170
112E2F1_18555785_Chip-Seq_ESCs_Mouse0.85320505
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85205597
114CMYC_18555785_Chip-Seq_ESCs_Mouse0.84743081
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84578753
116BCAT_22108803_ChIP-Seq_LS180_Human0.84500200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.98297722
2MP0003880_abnormal_central_pattern4.74896060
3MP0004270_analgesia3.90533269
4MP0003635_abnormal_synaptic_transmissio3.58803061
5MP0001968_abnormal_touch/_nociception3.11065073
6MP0005423_abnormal_somatic_nervous3.01631784
7MP0002063_abnormal_learning/memory/cond2.97798503
8MP0009745_abnormal_behavioral_response2.96294247
9MP0002734_abnormal_mechanical_nocicepti2.94224497
10MP0009046_muscle_twitch2.92608844
11MP0002735_abnormal_chemical_nociception2.85107226
12MP0002064_seizures2.83262307
13MP0006276_abnormal_autonomic_nervous2.80104087
14MP0002572_abnormal_emotion/affect_behav2.60497142
15MP0002272_abnormal_nervous_system2.50885827
16MP0001486_abnormal_startle_reflex2.46322227
17MP0002736_abnormal_nociception_after2.43800762
18MP0000778_abnormal_nervous_system2.32628860
19MP0002733_abnormal_thermal_nociception2.32184986
20MP0002184_abnormal_innervation2.14563125
21MP0001440_abnormal_grooming_behavior2.14525861
22MP0001970_abnormal_pain_threshold2.13266051
23MP0002067_abnormal_sensory_capabilities2.10261071
24MP0001984_abnormal_olfaction2.06792969
25MP0002822_catalepsy1.91552462
26MP0005386_behavior/neurological_phenoty1.81238110
27MP0004924_abnormal_behavior1.81238110
28MP0004858_abnormal_nervous_system1.80418129
29MP0002557_abnormal_social/conspecific_i1.80392393
30MP0001501_abnormal_sleep_pattern1.80332256
31MP0003121_genomic_imprinting1.79941737
32MP0004811_abnormal_neuron_physiology1.74062920
33MP0001529_abnormal_vocalization1.71683882
34MP0000955_abnormal_spinal_cord1.71515273
35MP0003329_amyloid_beta_deposits1.66508817
36MP0005645_abnormal_hypothalamus_physiol1.65585030
37MP0009780_abnormal_chondrocyte_physiolo1.63772263
38MP0005646_abnormal_pituitary_gland1.63233351
39MP0002882_abnormal_neuron_morphology1.60999295
40MP0005551_abnormal_eye_electrophysiolog1.57692635
41MP0008569_lethality_at_weaning1.57063372
42MP0000569_abnormal_digit_pigmentation1.55641872
43MP0003787_abnormal_imprinting1.50583094
44MP0004142_abnormal_muscle_tone1.49655778
45MP0002909_abnormal_adrenal_gland1.49103869
46MP0003122_maternal_imprinting1.47839922
47MP0001905_abnormal_dopamine_level1.45367112
48MP0002066_abnormal_motor_capabilities/c1.41162423
49MP0004742_abnormal_vestibular_system1.37738007
50MP0002102_abnormal_ear_morphology1.35339729
51MP0001502_abnormal_circadian_rhythm1.31894873
52MP0005187_abnormal_penis_morphology1.31170702
53MP0001188_hyperpigmentation1.30906423
54MP0002229_neurodegeneration1.30092568
55MP0004885_abnormal_endolymph1.29369411
56MP0003879_abnormal_hair_cell1.19369241
57MP0002152_abnormal_brain_morphology1.15138978
58MP0003633_abnormal_nervous_system1.14199867
59MP0004133_heterotaxia1.13356929
60MP0002752_abnormal_somatic_nervous1.10849640
61MP0002638_abnormal_pupillary_reflex1.10048476
62MP0008877_abnormal_DNA_methylation1.10040353
63MP0010386_abnormal_urinary_bladder1.09038050
64MP0003634_abnormal_glial_cell1.06332292
65MP0003631_nervous_system_phenotype1.04194313
66MP0005394_taste/olfaction_phenotype1.02838773
67MP0005499_abnormal_olfactory_system1.02838773
68MP0006072_abnormal_retinal_apoptosis1.01136946
69MP0006292_abnormal_olfactory_placode0.97284281
70MP0000631_abnormal_neuroendocrine_gland0.95662301
71MP0001963_abnormal_hearing_physiology0.95049002
72MP0005253_abnormal_eye_physiology0.94326029
73MP0002069_abnormal_eating/drinking_beha0.93127752
74MP0001986_abnormal_taste_sensitivity0.91435858
75MP0000920_abnormal_myelination0.89531921
76MP0003890_abnormal_embryonic-extraembry0.89504513
77MP0003938_abnormal_ear_development0.86717035
78MP0003183_abnormal_peptide_metabolism0.85803667
79MP0002751_abnormal_autonomic_nervous0.85774917
80MP0003632_abnormal_nervous_system0.84477819
81MP0005409_darkened_coat_color0.84368172
82MP0005248_abnormal_Harderian_gland0.84128894
83MP0005535_abnormal_body_temperature0.82655636
84MP0002876_abnormal_thyroid_physiology0.82061093
85MP0003136_yellow_coat_color0.80720803
86MP0002837_dystrophic_cardiac_calcinosis0.79733140
87MP0000751_myopathy0.79631002
88MP0002234_abnormal_pharynx_morphology0.79518286
89MP0000604_amyloidosis0.78285227
90MP0003119_abnormal_digestive_system0.77844230
91MP0004085_abnormal_heartbeat0.77698487
92MP0002090_abnormal_vision0.76506138
93MP0001299_abnormal_eye_distance/0.73635452
94MP0004145_abnormal_muscle_electrophysio0.72809447
95MP0000049_abnormal_middle_ear0.72004003
96MP0001485_abnormal_pinna_reflex0.71523995
97MP0003123_paternal_imprinting0.70634745
98MP0003283_abnormal_digestive_organ0.70488417
99MP0008872_abnormal_physiological_respon0.70304741
100MP0003690_abnormal_glial_cell0.68958074
101MP0002081_perinatal_lethality0.67979889
102MP0003861_abnormal_nervous_system0.67365194
103MP0005195_abnormal_posterior_eye0.65857404
104MP0000026_abnormal_inner_ear0.65432962
105MP0003137_abnormal_impulse_conducting0.64346388
106MP0001177_atelectasis0.63590317
107MP0004043_abnormal_pH_regulation0.63243011
108MP0008874_decreased_physiological_sensi0.62782229
109MP0002928_abnormal_bile_duct0.62075067
110MP0008789_abnormal_olfactory_epithelium0.59722421
111MP0001943_abnormal_respiration0.56985068
112MP0000013_abnormal_adipose_tissue0.56882162
113MP0002082_postnatal_lethality0.54991093
114MP0010770_preweaning_lethality0.54991093
115MP0001664_abnormal_digestion0.54555041
116MP0002653_abnormal_ependyma_morphology0.53407684
117MP0010769_abnormal_survival0.52972455

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.02536704
2Myokymia (HP:0002411)5.72468707
3Focal seizures (HP:0007359)4.93119581
4Atonic seizures (HP:0010819)4.44241823
5Epileptic encephalopathy (HP:0200134)4.38789284
6Febrile seizures (HP:0002373)4.36482902
7Progressive cerebellar ataxia (HP:0002073)4.20012824
8Visual hallucinations (HP:0002367)4.18128158
9Supranuclear gaze palsy (HP:0000605)3.96299722
10Absence seizures (HP:0002121)3.74796922
11Action tremor (HP:0002345)3.56915086
12Ankle clonus (HP:0011448)3.50331134
13Limb dystonia (HP:0002451)3.47994947
14Generalized tonic-clonic seizures (HP:0002069)3.41226156
15Dialeptic seizures (HP:0011146)3.40928960
16Hyperventilation (HP:0002883)3.40792475
17Abnormality of the corticospinal tract (HP:0002492)3.31770162
18Pheochromocytoma (HP:0002666)3.22371573
19Broad-based gait (HP:0002136)3.18971668
20Insidious onset (HP:0003587)3.14794307
21Termporal pattern (HP:0011008)3.14794307
22Amblyopia (HP:0000646)2.93355763
23Truncal ataxia (HP:0002078)2.91981183
24Impaired vibration sensation in the lower limbs (HP:0002166)2.90580371
25Progressive inability to walk (HP:0002505)2.90524366
26Polyphagia (HP:0002591)2.90517348
27Drooling (HP:0002307)2.89854318
28Excessive salivation (HP:0003781)2.89854318
29Spastic gait (HP:0002064)2.88339757
30Mutism (HP:0002300)2.85967072
31Abnormal eating behavior (HP:0100738)2.85446464
32Urinary bladder sphincter dysfunction (HP:0002839)2.81796267
33Neuroendocrine neoplasm (HP:0100634)2.77651366
34Gaze-evoked nystagmus (HP:0000640)2.72939229
35Urinary urgency (HP:0000012)2.64060874
36Lissencephaly (HP:0001339)2.63199998
37Neurofibrillary tangles (HP:0002185)2.62785965
38Gait imbalance (HP:0002141)2.62243672
39Pachygyria (HP:0001302)2.59302414
40Hepatoblastoma (HP:0002884)2.58952430
41Epileptiform EEG discharges (HP:0011182)2.58695955
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.58189220
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.58189220
44Anxiety (HP:0000739)2.56945127
45Depression (HP:0000716)2.56761691
46Dysdiadochokinesis (HP:0002075)2.56703077
47Dysmetria (HP:0001310)2.55916053
48EEG with generalized epileptiform discharges (HP:0011198)2.54354992
49Agitation (HP:0000713)2.50599812
50Poor eye contact (HP:0000817)2.48588537
51Failure to thrive in infancy (HP:0001531)2.46903772
52Hypsarrhythmia (HP:0002521)2.43444357
53Cortical dysplasia (HP:0002539)2.37885131
54Cerebral inclusion bodies (HP:0100314)2.37318935
55Spastic tetraplegia (HP:0002510)2.37201711
56Genetic anticipation (HP:0003743)2.36004378
57Abnormal social behavior (HP:0012433)2.34867278
58Impaired social interactions (HP:0000735)2.34867278
59Lower limb muscle weakness (HP:0007340)2.34747474
60Absent speech (HP:0001344)2.33407818
61Akinesia (HP:0002304)2.31600595
62Central scotoma (HP:0000603)2.30987361
63Hemiparesis (HP:0001269)2.30682900
64Ulnar claw (HP:0001178)2.30089315
65Specific learning disability (HP:0001328)2.28520224
66Nephronophthisis (HP:0000090)2.26903344
67True hermaphroditism (HP:0010459)2.26534594
68Scanning speech (HP:0002168)2.25798848
69Inability to walk (HP:0002540)2.22466757
70Abnormality of the labia minora (HP:0012880)2.20747322
71Postural instability (HP:0002172)2.20299752
72Hypoplasia of the brainstem (HP:0002365)2.19820002
73Aplasia/Hypoplasia of the brainstem (HP:0007362)2.19820002
74Torticollis (HP:0000473)2.18856814
75Fetal akinesia sequence (HP:0001989)2.17166044
76Abnormal hair whorl (HP:0010721)2.15155400
77Pancreatic fibrosis (HP:0100732)2.14038600
78Morphological abnormality of the pyramidal tract (HP:0002062)2.12604789
79Hypothermia (HP:0002045)2.09646304
80Abnormality of midbrain morphology (HP:0002418)2.06364788
81Molar tooth sign on MRI (HP:0002419)2.06364788
82Sleep apnea (HP:0010535)2.06218308
83Blue irides (HP:0000635)2.05536577
84Papilledema (HP:0001085)2.04744030
85Hypoplasia of the corpus callosum (HP:0002079)2.04475115
86Diplopia (HP:0000651)2.04137224
87Abnormality of binocular vision (HP:0011514)2.04137224
88Congenital primary aphakia (HP:0007707)2.03765091
89Medial flaring of the eyebrow (HP:0010747)2.03731189
90Exotropia (HP:0000577)2.02830401
91Bradykinesia (HP:0002067)2.01409512
92Focal dystonia (HP:0004373)2.01348034
93Amyotrophic lateral sclerosis (HP:0007354)2.00743301
94Pancreatic cysts (HP:0001737)2.00223735
95Intention tremor (HP:0002080)1.99744522
96Abnormality of salivation (HP:0100755)1.97856573
97Protruding tongue (HP:0010808)1.97617476
98Esotropia (HP:0000565)1.96864990
99Optic nerve hypoplasia (HP:0000609)1.95598304
100Intestinal atresia (HP:0011100)1.95308207
101Abnormality of macular pigmentation (HP:0008002)1.94243276
102Nephrogenic diabetes insipidus (HP:0009806)1.94110124
103Megalencephaly (HP:0001355)1.92731657
104Status epilepticus (HP:0002133)1.91769512
105Impaired vibratory sensation (HP:0002495)1.91598297
106Hypoventilation (HP:0002791)1.91559823
107Genital tract atresia (HP:0001827)1.89688469
108Chronic hepatic failure (HP:0100626)1.89189224
109Clonus (HP:0002169)1.88308872
110Psychosis (HP:0000709)1.87820902
111Impaired smooth pursuit (HP:0007772)1.87719531
112Retinal dysplasia (HP:0007973)1.87586851
113Abnormality of the lower motor neuron (HP:0002366)1.86922544
114Craniofacial dystonia (HP:0012179)1.86456140
115Oligodactyly (hands) (HP:0001180)1.85700404
116Stereotypic behavior (HP:0000733)1.85632145
117Vaginal atresia (HP:0000148)1.85218897
118Abnormality of the renal medulla (HP:0100957)1.85203422
119Hemiplegia (HP:0002301)1.84110074
120Generalized myoclonic seizures (HP:0002123)1.84064076
121Congenital stationary night blindness (HP:0007642)1.83220746
122Postural tremor (HP:0002174)1.83208482
123Morphological abnormality of the middle ear (HP:0008609)1.80659649
124Split foot (HP:0001839)1.78934250
125Poor coordination (HP:0002370)1.78175264
126Muscular hypotonia of the trunk (HP:0008936)1.77789151
127Intellectual disability, severe (HP:0010864)1.77254019
128Poor suck (HP:0002033)1.74943352
129Postaxial hand polydactyly (HP:0001162)1.70710766
130Narrow forehead (HP:0000341)1.69031417
131Inappropriate behavior (HP:0000719)1.66405603
132Paraplegia (HP:0010550)1.65505272
133Cutaneous finger syndactyly (HP:0010554)1.64680570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.71863418
2NTRK33.82818833
3MAP3K43.22700553
4MAP3K93.12433653
5CASK3.07256035
6MAP2K72.84568825
7MINK12.74506200
8EPHA42.48984706
9NTRK22.20122596
10MAPK132.05498678
11MAP3K121.96375324
12DAPK21.94234571
13MAP2K41.93281331
14PAK61.83483073
15NTRK11.76950974
16EPHA31.75445863
17PNCK1.74412000
18FRK1.62457594
19PHKG11.53165955
20PHKG21.53165955
21KSR11.52925743
22TNIK1.52657010
23SIK21.47131661
24CDK51.45247108
25KSR21.40739869
26UHMK11.40444646
27TRIM281.38077900
28GRK51.34142178
29SGK4941.31713397
30SGK2231.31713397
31PLK21.31437225
32OXSR11.22007817
33CAMKK11.20153721
34CDK191.19878023
35DYRK21.16275360
36PRKCG1.15126396
37BCR1.13875876
38CSNK1G21.13601508
39PRPF4B1.13089847
40RIPK41.10503181
41SIK31.07305936
42ARAF1.07105775
43MAP4K21.02441746
44WNK31.01672084
45DAPK11.01523299
46SGK20.98767169
47MAP3K20.98723374
48ERBB30.98170070
49CAMK2A0.97488034
50CAMKK20.96546505
51EPHB20.95921373
52STK390.95535834
53PAK30.91744445
54LIMK10.89238787
55CAMK2B0.87202780
56RET0.84615488
57DYRK1A0.82861237
58PKN10.82558122
59CDK180.82098379
60CDK140.81585073
61FES0.78673079
62PRKD30.78275829
63DYRK1B0.78232304
64CAMK1G0.77923351
65LATS20.77034322
66CDK150.76412839
67CSNK1G30.76242754
68DYRK30.73380097
69WNK10.72512652
70TYRO30.72414652
71AKT30.71730636
72STK110.70571216
73PRKCE0.68808313
74MARK20.68202466
75WNK40.68155554
76PRKCZ0.66884686
77SGK30.66839035
78LMTK20.65632997
79CDK11A0.64822407
80STK380.63897367
81IRAK20.61721960
82RPS6KA20.60933007
83FGFR20.60831487
84CAMK2D0.58898234
85SGK10.58774402
86INSRR0.58300594
87CSNK1A1L0.58152714
88PRKCH0.56601093
89BMPR1B0.56182195
90ADRBK20.55753890
91CAMK2G0.53342769
92FER0.51321470
93CAMK40.50798058
94MAP3K60.50376090
95CAMK10.49361197
96GRK70.48574584
97BMPR20.48416774
98PINK10.47748209
99ADRBK10.47498479
100PRKG10.44745960
101ERBB20.44678349
102CSNK1D0.44359839
103FYN0.43583741
104MKNK20.42980225
105FGR0.42642821
106PRKACA0.41810240
107CSNK1G10.41776438
108NME10.41706915
109CSNK1E0.40555839
110RPS6KA30.40397386
111MAP2K10.40204342
112YES10.39154175
113MAPK100.38759350
114PRKACB0.38644995
115CDC42BPA0.37984638
116ROCK20.37716608
117PRKCB0.36209665
118PRKAA10.33024083
119CSNK1A10.32936782
120GRK10.32853406
121CCNB10.32767442
122MAPK150.30955166
123RPS6KA40.28985765
124CDK30.27796763
125MAPK90.27482733

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.62720565
2Synaptic vesicle cycle_Homo sapiens_hsa047213.56396333
3GABAergic synapse_Homo sapiens_hsa047272.67366085
4Olfactory transduction_Homo sapiens_hsa047402.63494549
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60792528
6Circadian entrainment_Homo sapiens_hsa047132.42195161
7Glutamatergic synapse_Homo sapiens_hsa047242.39578751
8Morphine addiction_Homo sapiens_hsa050322.35752079
9Long-term potentiation_Homo sapiens_hsa047202.20883706
10Dopaminergic synapse_Homo sapiens_hsa047282.20799421
11Phototransduction_Homo sapiens_hsa047442.17900729
12Amphetamine addiction_Homo sapiens_hsa050312.12972960
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07826265
14Collecting duct acid secretion_Homo sapiens_hsa049662.01434301
15Insulin secretion_Homo sapiens_hsa049111.94766614
16Taste transduction_Homo sapiens_hsa047421.93292162
17Cholinergic synapse_Homo sapiens_hsa047251.90151310
18Serotonergic synapse_Homo sapiens_hsa047261.84648791
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.83051278
20Salivary secretion_Homo sapiens_hsa049701.75418824
21Cocaine addiction_Homo sapiens_hsa050301.68779585
22Long-term depression_Homo sapiens_hsa047301.59386983
23Gastric acid secretion_Homo sapiens_hsa049711.52856461
24Renin secretion_Homo sapiens_hsa049241.49797808
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47976313
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44396507
27Axon guidance_Homo sapiens_hsa043601.44027570
28Oxytocin signaling pathway_Homo sapiens_hsa049211.34585655
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34256063
30Vibrio cholerae infection_Homo sapiens_hsa051101.31262090
31Calcium signaling pathway_Homo sapiens_hsa040201.26164561
32Gap junction_Homo sapiens_hsa045401.25195581
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25147357
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22282929
35GnRH signaling pathway_Homo sapiens_hsa049121.22081553
36Type II diabetes mellitus_Homo sapiens_hsa049301.21080422
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13677090
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07360175
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05905682
40Cardiac muscle contraction_Homo sapiens_hsa042601.05292330
41ErbB signaling pathway_Homo sapiens_hsa040121.04952548
42cAMP signaling pathway_Homo sapiens_hsa040241.03887232
43Steroid biosynthesis_Homo sapiens_hsa001001.03620449
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02087816
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00026875
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96119553
47Oxidative phosphorylation_Homo sapiens_hsa001900.95766109
48Estrogen signaling pathway_Homo sapiens_hsa049150.95462909
49Melanogenesis_Homo sapiens_hsa049160.86970907
50Glioma_Homo sapiens_hsa052140.86458050
51Alzheimers disease_Homo sapiens_hsa050100.85540978
52Hedgehog signaling pathway_Homo sapiens_hsa043400.81591299
53Protein export_Homo sapiens_hsa030600.80767040
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80108198
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79610134
56Butanoate metabolism_Homo sapiens_hsa006500.74929911
57Dorso-ventral axis formation_Homo sapiens_hsa043200.74625138
58Hippo signaling pathway_Homo sapiens_hsa043900.73935013
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.73496114
60Parkinsons disease_Homo sapiens_hsa050120.72266370
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.68898793
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68609760
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66373403
64Pancreatic secretion_Homo sapiens_hsa049720.63908197
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.62743604
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62003149
67MAPK signaling pathway_Homo sapiens_hsa040100.61372413
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60046091
69Oocyte meiosis_Homo sapiens_hsa041140.59672783
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59657091
71Thyroid hormone synthesis_Homo sapiens_hsa049180.59431952
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59122437
73Choline metabolism in cancer_Homo sapiens_hsa052310.58394153
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.58163654
75Ether lipid metabolism_Homo sapiens_hsa005650.57560472
76Basal cell carcinoma_Homo sapiens_hsa052170.57421228
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57190938
78Alcoholism_Homo sapiens_hsa050340.56826904
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56323920
80Ras signaling pathway_Homo sapiens_hsa040140.56238143
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54778908
82Endometrial cancer_Homo sapiens_hsa052130.52405001
83Bile secretion_Homo sapiens_hsa049760.48500467
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48187606
85Phagosome_Homo sapiens_hsa041450.48141746
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48052582
87Renal cell carcinoma_Homo sapiens_hsa052110.47642581
88Glucagon signaling pathway_Homo sapiens_hsa049220.47279336
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.47127056
90Dilated cardiomyopathy_Homo sapiens_hsa054140.44402645
91Tight junction_Homo sapiens_hsa045300.43327758
92Prion diseases_Homo sapiens_hsa050200.43295907
93Type I diabetes mellitus_Homo sapiens_hsa049400.43220536
94Insulin signaling pathway_Homo sapiens_hsa049100.42749306
95Inositol phosphate metabolism_Homo sapiens_hsa005620.42676237
96Endocytosis_Homo sapiens_hsa041440.41205564
97Circadian rhythm_Homo sapiens_hsa047100.40943028
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40919234
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40872670
100Huntingtons disease_Homo sapiens_hsa050160.40831584
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40314099
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38378613
103Rheumatoid arthritis_Homo sapiens_hsa053230.37617047
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37537480
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36477526
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36419836
107VEGF signaling pathway_Homo sapiens_hsa043700.36298932
108Ovarian steroidogenesis_Homo sapiens_hsa049130.35253120
109Prolactin signaling pathway_Homo sapiens_hsa049170.34604802
110Rap1 signaling pathway_Homo sapiens_hsa040150.33903907
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33493295
112mTOR signaling pathway_Homo sapiens_hsa041500.33195363
113Regulation of autophagy_Homo sapiens_hsa041400.33052754
114Wnt signaling pathway_Homo sapiens_hsa043100.32868786
115Colorectal cancer_Homo sapiens_hsa052100.30283263
116AMPK signaling pathway_Homo sapiens_hsa041520.29830225
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29556338

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