RUFY4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1valine metabolic process (GO:0006573)5.19032557
2immunoglobulin mediated immune response (GO:0016064)5.06553818
3detection of other organism (GO:0098543)4.58804987
4macrophage activation involved in immune response (GO:0002281)4.53516433
5detection of bacterium (GO:0016045)4.50352065
6negative regulation of cell killing (GO:0031342)4.33973172
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.33973172
8pentose-phosphate shunt (GO:0006098)4.32826710
9type I interferon signaling pathway (GO:0060337)4.21009717
10cellular response to type I interferon (GO:0071357)4.21009717
11interferon-gamma-mediated signaling pathway (GO:0060333)4.20544672
12response to type I interferon (GO:0034340)4.17831770
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.16481404
14production of molecular mediator involved in inflammatory response (GO:0002532)4.10911332
15regulation of sequestering of triglyceride (GO:0010889)4.03861932
16NADPH regeneration (GO:0006740)4.03851624
17negative regulation of phagocytosis (GO:0050765)3.96792697
18B cell mediated immunity (GO:0019724)3.94057924
19regulation of dendritic cell antigen processing and presentation (GO:0002604)3.91688466
20positive regulation of antigen processing and presentation (GO:0002579)3.85676713
21regulation of gamma-delta T cell activation (GO:0046643)3.82774169
22fatty acid beta-oxidation (GO:0006635)3.81458711
23detection of external biotic stimulus (GO:0098581)3.78236249
24macrophage differentiation (GO:0030225)3.73124764
25regulation of cholesterol storage (GO:0010885)3.72650989
26regulation of antigen processing and presentation (GO:0002577)3.67966412
27positive regulation of type 2 immune response (GO:0002830)3.65194277
28T-helper 1 type immune response (GO:0042088)3.63014595
29thrombin receptor signaling pathway (GO:0070493)3.60700849
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.59536036
31positive regulation of mast cell activation (GO:0033005)3.59381228
32fatty acid oxidation (GO:0019395)3.58210275
33neutrophil activation involved in immune response (GO:0002283)3.57699929
34pentose metabolic process (GO:0019321)3.52154492
35lipid oxidation (GO:0034440)3.52134755
36regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.51276601
37negative regulation of T cell mediated immunity (GO:0002710)3.50287993
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.50116160
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.50116160
40apoptotic cell clearance (GO:0043277)3.46968044
41low-density lipoprotein particle clearance (GO:0034383)3.44922179
42germinal center formation (GO:0002467)3.44752923
43positive regulation by symbiont of host defense response (GO:0052509)3.44400654
44modulation by symbiont of host defense response (GO:0052031)3.44400654
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.44400654
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.44400654
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.44400654
48modulation by symbiont of host immune response (GO:0052553)3.44400654
49myeloid dendritic cell differentiation (GO:0043011)3.43161829
50detection of molecule of bacterial origin (GO:0032490)3.43060361
51toxin transport (GO:1901998)3.42600710
52branched-chain amino acid metabolic process (GO:0009081)3.41819915
53regulation of mast cell degranulation (GO:0043304)3.41221911
54tricarboxylic acid metabolic process (GO:0072350)3.39730381
55fatty acid catabolic process (GO:0009062)3.38388971
56myeloid cell activation involved in immune response (GO:0002275)3.37733783
57detection of biotic stimulus (GO:0009595)3.37648552
58leukocyte aggregation (GO:0070486)3.35730499
59defense response to fungus (GO:0050832)3.32231945
60lipopolysaccharide-mediated signaling pathway (GO:0031663)3.31666281
61negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.31533740
62positive regulation of cellular amide metabolic process (GO:0034250)3.30198974
63myeloid dendritic cell activation (GO:0001773)3.29474611
64disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.27959578
65killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.27959578
66response to protozoan (GO:0001562)3.27427453
67negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.24796892
68regulation of mast cell activation (GO:0033003)3.24491539
69cellular response to interferon-gamma (GO:0071346)3.24321223
70regulation of T-helper 2 cell differentiation (GO:0045628)3.23893144
71positive regulation of interferon-alpha production (GO:0032727)3.23826645
72brown fat cell differentiation (GO:0050873)3.23729890
73positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23672891
74regulation of type 2 immune response (GO:0002828)3.23202351
75alpha-linolenic acid metabolic process (GO:0036109)3.22132244
76regulation of interferon-alpha production (GO:0032647)3.21844361
77NIK/NF-kappaB signaling (GO:0038061)3.21665120
78regulation of T cell tolerance induction (GO:0002664)3.20308353
79defense response to protozoan (GO:0042832)3.19529008
80negative regulation of lymphocyte mediated immunity (GO:0002707)3.19235885
81leukocyte migration involved in inflammatory response (GO:0002523)3.18896680
82regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16597421
83T cell migration (GO:0072678)3.15624390
84regulation of mast cell activation involved in immune response (GO:0033006)3.14157954
85positive regulation of fatty acid beta-oxidation (GO:0032000)3.13724203
86positive regulation of mast cell activation involved in immune response (GO:0033008)3.13352812
87positive regulation of mast cell degranulation (GO:0043306)3.13352812
88negative thymic T cell selection (GO:0045060)3.11126367
89positive regulation of fatty acid oxidation (GO:0046321)3.10845940
90NADP metabolic process (GO:0006739)3.10378809
91cellular extravasation (GO:0045123)3.10243147
92regulation of tolerance induction (GO:0002643)3.10038364
93regulation of hypersensitivity (GO:0002883)3.09038311
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.07591697
95lysine metabolic process (GO:0006553)3.06976332
96lysine catabolic process (GO:0006554)3.06976332
97response to interferon-gamma (GO:0034341)3.05745264
98phospholipid homeostasis (GO:0055091)3.05573800
99response to peptidoglycan (GO:0032494)3.05408236
100neutrophil activation (GO:0042119)3.05086646
101macrophage activation (GO:0042116)3.04313893
102microglial cell activation (GO:0001774)3.02727812
103regulation of leukocyte degranulation (GO:0043300)3.02680219
104branched-chain amino acid catabolic process (GO:0009083)3.01636397
105regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.00768060
1062-oxoglutarate metabolic process (GO:0006103)3.00012367
107aminoglycoside antibiotic metabolic process (GO:0030647)2.99875769
108negative regulation of leukocyte mediated immunity (GO:0002704)2.97568464
109positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.95509092
110regulation of gamma-delta T cell differentiation (GO:0045586)2.93907623
111regulation of interleukin-2 biosynthetic process (GO:0045076)2.92854748
112negative regulation of cytokine production involved in immune response (GO:0002719)2.91877362
113neutrophil mediated immunity (GO:0002446)2.91791112
114mannose metabolic process (GO:0006013)2.91437464
115respiratory burst (GO:0045730)2.90109435
116sodium-independent organic anion transport (GO:0043252)2.89757138
117glucose catabolic process (GO:0006007)2.89087102
118positive regulation of natural killer cell differentiation (GO:0032825)2.89085282
119positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.88698232
120definitive hemopoiesis (GO:0060216)2.88588987
121lipid storage (GO:0019915)2.88054345
122negative regulation of lipid storage (GO:0010888)2.87511125
123negative T cell selection (GO:0043383)2.86348690
124monocarboxylic acid catabolic process (GO:0072329)2.85383585
125granulocyte activation (GO:0036230)2.85165000
126negative regulation of interleukin-12 production (GO:0032695)2.83471186
127negative regulation of granulocyte differentiation (GO:0030853)2.83117608
128protein carboxylation (GO:0018214)2.82981215
129peptidyl-glutamic acid carboxylation (GO:0017187)2.82981215
130positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.82919382
131antigen processing and presentation of endogenous antigen (GO:0019883)2.82610149
132positive thymic T cell selection (GO:0045059)2.82371485
133negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.81589966
134positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.80302784
135white fat cell differentiation (GO:0050872)2.80106861
136regulation of type I interferon-mediated signaling pathway (GO:0060338)2.79881462
137regulation of T-helper 1 cell differentiation (GO:0045625)2.79865223
138regulation of B cell receptor signaling pathway (GO:0050855)2.79842096
139positive regulation of B cell differentiation (GO:0045579)2.79281533
140regulation of fatty acid oxidation (GO:0046320)2.78860826
141cellular response to zinc ion (GO:0071294)2.77727186
142regulation of B cell differentiation (GO:0045577)2.76587327
143response to fungus (GO:0009620)2.76322461
144regulation of fatty acid beta-oxidation (GO:0031998)2.75701029
145positive regulation of fatty acid metabolic process (GO:0045923)2.75446161
146drug transmembrane transport (GO:0006855)2.74603725
147oxaloacetate metabolic process (GO:0006107)2.74534944
148primary alcohol catabolic process (GO:0034310)2.72796783
149response to muramyl dipeptide (GO:0032495)2.72368670
150regulation of natural killer cell differentiation (GO:0032823)2.70887871
151carnitine metabolic process (GO:0009437)2.69268717
152drug transport (GO:0015893)2.68269589
153positive regulation of lipid catabolic process (GO:0050996)2.62587042
154positive regulation of gamma-delta T cell activation (GO:0046645)2.62393439
155negative regulation of erythrocyte differentiation (GO:0045647)2.62151277
156Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60859436
157glyoxylate metabolic process (GO:0046487)2.60652491
158response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.57681099
159response to host immune response (GO:0052572)2.57681099
160response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.56971701
161response to host (GO:0075136)2.56971701
162response to host defenses (GO:0052200)2.56971701
163fatty acid transmembrane transport (GO:1902001)2.55823340
164quaternary ammonium group transport (GO:0015697)2.55206755
165positive regulation of sterol transport (GO:0032373)2.54777670
166positive regulation of cholesterol transport (GO:0032376)2.54777670
167regulation of triglyceride catabolic process (GO:0010896)2.54211787
168regulation of interferon-beta biosynthetic process (GO:0045357)2.53652008
169positive regulation of fatty acid biosynthetic process (GO:0045723)2.50621072
170sulfur amino acid catabolic process (GO:0000098)2.50584505
171biotin metabolic process (GO:0006768)2.49509805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.28128757
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.12645343
3MYB_21317192_ChIP-Seq_ERMYB_Mouse3.33309364
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.15542143
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.14505946
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.00096059
7SCL_19346495_ChIP-Seq_HPC-7_Human2.91192773
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.85205787
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.82299996
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.78201935
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.65762264
12VDR_21846776_ChIP-Seq_THP-1_Human2.47089537
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.45264500
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.44564057
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.32859299
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31368564
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27500352
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24993343
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19486317
20MYC_22102868_ChIP-Seq_BL_Human2.15399536
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15289080
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.14088629
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12555116
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.11420354
25CLOCK_20551151_ChIP-Seq_293T_Human2.07877058
26VDR_24763502_ChIP-Seq_THP-1_Human1.99344589
27GATA1_22025678_ChIP-Seq_K562_Human1.89280556
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.87516931
29TCF7_22412390_ChIP-Seq_EML_Mouse1.86239408
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83536817
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73147682
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.73137668
33MAF_26560356_Chip-Seq_TH1_Human1.72655321
34* SPI1_23547873_ChIP-Seq_NB4_Human1.67997955
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64135523
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.61595911
37UTX_26944678_Chip-Seq_JUKART_Human1.61144036
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57864025
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56077212
40LXR_22292898_ChIP-Seq_THP-1_Human1.55429896
41* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54797246
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49170861
43KDM2B_26808549_Chip-Seq_DND41_Human1.46319866
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44535363
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44243835
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43429929
47GATA3_27048872_Chip-Seq_THYMUS_Human1.42755292
48GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42460937
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41278418
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40924901
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40500842
52SPI1_23127762_ChIP-Seq_K562_Human1.40010184
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37946802
54MYB_26560356_Chip-Seq_TH2_Human1.37866238
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37436744
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37030694
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35089415
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33329175
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33327970
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32649448
61* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32585024
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31483501
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31360061
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.30977390
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.30412051
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30114503
67RACK7_27058665_Chip-Seq_MCF-7_Human1.26041776
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25069740
69MYB_26560356_Chip-Seq_TH1_Human1.24957471
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24656200
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23320737
72* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21317817
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19269129
74* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18382858
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18217181
76* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17865584
77FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17736088
78RUNX_20019798_ChIP-Seq_JUKART_Human1.17592209
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16241153
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.15982938
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15361204
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15181204
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14993257
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13951041
85* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13597221
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13572240
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13451740
88GATA1_19941826_ChIP-Seq_K562_Human1.11668335
89GATA2_19941826_ChIP-Seq_K562_Human1.11142774
90* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10591967
91BCL6_27268052_Chip-Seq_Bcells_Human1.10120062
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09272516
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08575355
94FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06959992
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06502646
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04542235
97* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04063718
98MAF_26560356_Chip-Seq_TH2_Human1.03857344
99GATA3_26560356_Chip-Seq_TH2_Human1.03682018
100FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03619531
101* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02822469
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01847407
103VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01507809
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00861853
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.00805999
106* PU_27001747_Chip-Seq_BMDM_Mouse0.99495202
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98104156
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98014762
109SPI1_20517297_ChIP-Seq_HL60_Human0.97752180
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.97412236
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96936830
112NCOR1_26117541_ChIP-Seq_K562_Human0.95670497
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95547656
114BCOR_27268052_Chip-Seq_Bcells_Human0.94981674
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94916294
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94671259
117VDR_24787735_ChIP-Seq_THP-1_Human0.94339110
118* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94129222
119ESR2_21235772_ChIP-Seq_MCF-7_Human0.93914840
120KDM2B_26808549_Chip-Seq_JURKAT_Human0.89714057
121EGR1_19032775_ChIP-ChIP_M12_Human0.79412080
122TFEB_21752829_ChIP-Seq_HELA_Human0.78289120
123* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.77529201
124STAT1_20625510_ChIP-Seq_HELA_Human0.76340415
125GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75393756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol3.32063718
2MP0006082_CNS_inflammation3.13475414
3MP0004510_myositis2.88818210
4MP0005670_abnormal_white_adipose2.85954846
5MP0009840_abnormal_foam_cell2.85408091
6MP0003724_increased_susceptibility_to2.72812727
7MP0009278_abnormal_bone_marrow2.70474910
8MP0003436_decreased_susceptibility_to2.64822527
9MP0005464_abnormal_platelet_physiology2.21987243
10MP0000465_gastrointestinal_hemorrhage2.21667695
11MP0002396_abnormal_hematopoietic_system2.20033732
12MP0005360_urolithiasis2.19231487
13MP0002419_abnormal_innate_immunity2.18699517
14MP0005058_abnormal_lysosome_morphology2.15790717
15MP0002837_dystrophic_cardiac_calcinosis2.11667347
16MP0003303_peritoneal_inflammation2.09395864
17MP0001545_abnormal_hematopoietic_system2.08693762
18MP0005397_hematopoietic_system_phenotyp2.08693762
19MP0002139_abnormal_hepatobiliary_system2.07250036
20MP0005365_abnormal_bile_salt2.04840753
21MP0000343_altered_response_to2.01819319
22MP0001853_heart_inflammation2.01164235
23MP0004130_abnormal_muscle_cell1.96478706
24MP0009764_decreased_sensitivity_to1.87925851
25MP0004185_abnormal_adipocyte_glucose1.79673618
26MP0005666_abnormal_adipose_tissue1.78973509
27MP0010329_abnormal_lipoprotein_level1.76718279
28MP0003300_gastrointestinal_ulcer1.69277104
29MP0001533_abnormal_skeleton_physiology1.67671192
30MP0001835_abnormal_antigen_presentation1.67627125
31MP0008004_abnormal_stomach_pH1.66155124
32MP0009785_altered_susceptibility_to1.62900783
33MP0005310_abnormal_salivary_gland1.60012669
34MP0003566_abnormal_cell_adhesion1.59133896
35MP0003075_altered_response_to1.58704211
36MP0005085_abnormal_gallbladder_physiolo1.57751574
37MP0005025_abnormal_response_to1.54382511
38MP0003279_aneurysm1.52693756
39MP0000604_amyloidosis1.51132424
40MP0005451_abnormal_body_composition1.50877141
41MP0003828_pulmonary_edema1.42146271
42MP0009333_abnormal_splenocyte_physiolog1.41907210
43MP0004808_abnormal_hematopoietic_stem1.41358565
44MP0003763_abnormal_thymus_physiology1.41041032
45MP0003705_abnormal_hypodermis_morpholog1.40892899
46MP0003172_abnormal_lysosome_physiology1.40842714
47MP0000858_altered_metastatic_potential1.38348180
48MP0002971_abnormal_brown_adipose1.37589284
49MP0000609_abnormal_liver_physiology1.36242146
50MP0002452_abnormal_antigen_presenting1.35369060
51MP0008469_abnormal_protein_level1.35192401
52MP0008260_abnormal_autophagy1.33527931
53MP0005319_abnormal_enzyme/_coenzyme1.32751254
54MP0005000_abnormal_immune_tolerance1.32513319
55MP0002166_altered_tumor_susceptibility1.29216216
56MP0002405_respiratory_system_inflammati1.28398581
57MP0000569_abnormal_digit_pigmentation1.25824286
58MP0005167_abnormal_blood-brain_barrier1.25699748
59MP0005332_abnormal_amino_acid1.25161741
60MP0001845_abnormal_inflammatory_respons1.24222720
61MP0001819_abnormal_immune_cell1.23198501
62MP0002420_abnormal_adaptive_immunity1.22928112
63MP0008875_abnormal_xenobiotic_pharmacok1.21662624
64MP0003011_delayed_dark_adaptation1.21532608
65MP0002118_abnormal_lipid_homeostasis1.20568676
66MP0008438_abnormal_cutaneous_collagen1.20474960
67MP0003448_altered_tumor_morphology1.18934751
68MP0001764_abnormal_homeostasis1.17256380
69MP0002138_abnormal_hepatobiliary_system1.17125938
70MP0002148_abnormal_hypersensitivity_rea1.16458228
71MP0005375_adipose_tissue_phenotype1.16143418
72MP0003252_abnormal_bile_duct1.16029661
73MP0001800_abnormal_humoral_immune1.13393239
74MP0003183_abnormal_peptide_metabolism1.13168970
75MP0003186_abnormal_redox_activity1.12911209
76MP0001958_emphysema1.10862397
77MP0002723_abnormal_immune_serum1.10605628
78MP0001851_eye_inflammation1.09047481
79MP0001790_abnormal_immune_system1.08355263
80MP0005387_immune_system_phenotype1.08355263
81MP0002933_joint_inflammation1.08129856
82MP0003806_abnormal_nucleotide_metabolis1.07510612
83MP0005023_abnormal_wound_healing1.07439986
84MP0005584_abnormal_enzyme/coenzyme_acti1.07144802
85MP0003221_abnormal_cardiomyocyte_apopto1.06551735
86MP0005334_abnormal_fat_pad1.01863436
87MP0010155_abnormal_intestine_physiology1.00912590
88MP0003690_abnormal_glial_cell1.00572851
89MP0009643_abnormal_urine_homeostasis0.99143363
90MP0009115_abnormal_fat_cell0.99069837
91MP0003638_abnormal_response/metabolism_0.98832573
92MP0002998_abnormal_bone_remodeling0.98652496
93MP0002254_reproductive_system_inflammat0.97691367
94MP0009763_increased_sensitivity_to0.97238135
95MP0003866_abnormal_defecation0.96385912
96MP0000689_abnormal_spleen_morphology0.94654745
97MP0000685_abnormal_immune_system0.93062871
98MP0000716_abnormal_immune_system0.92887548
99MP0005164_abnormal_response_to0.92114994
100MP0002970_abnormal_white_adipose0.92050857
101MP0002398_abnormal_bone_marrow0.90547595
102MP0000598_abnormal_liver_morphology0.90510394
103MP0010352_gastrointestinal_tract_polyps0.90297129
104MP0005390_skeleton_phenotype0.89100695
105MP0005671_abnormal_response_to0.88863640
106MP0003091_abnormal_cell_migration0.88827905
107MP0000920_abnormal_myelination0.88725745
108MP0001873_stomach_inflammation0.87856146
109MP0005166_decreased_susceptibility_to0.86812380
110MP0008961_abnormal_basal_metabolism0.86810573
111MP0003453_abnormal_keratinocyte_physiol0.85985923
112MP0002429_abnormal_blood_cell0.85899758
113MP0004883_abnormal_blood_vessel0.85886768
114MP0005174_abnormal_tail_pigmentation0.85654667
115MP0004947_skin_inflammation0.84777429
116MP0002722_abnormal_immune_system0.84692177
117MP0002277_abnormal_respiratory_mucosa0.84551640
118MP0004019_abnormal_vitamin_homeostasis0.83620437
119MP0004264_abnormal_extraembryonic_tissu0.83591369
120MP0006036_abnormal_mitochondrial_physio0.83249801
121MP0000703_abnormal_thymus_morphology0.80884153
122MP0008874_decreased_physiological_sensi0.79472145
123MP0005647_abnormal_sex_gland0.79050100
124MP0000015_abnormal_ear_pigmentation0.76606738
125MP0003795_abnormal_bone_structure0.75159396
126MP0002132_abnormal_respiratory_system0.72667392
127MP0000249_abnormal_blood_vessel0.70714783
128MP0003656_abnormal_erythrocyte_physiolo0.70457667
129MP0009765_abnormal_xenobiotic_induced0.69846341
130MP0001663_abnormal_digestive_system0.69246055
131MP0000371_diluted_coat_color0.68607654
132MP0002006_tumorigenesis0.67248246
133MP0005076_abnormal_cell_differentiation0.63446350
134MP0003045_fibrosis0.57784406
135MP0001542_abnormal_bone_strength0.52624916
136MP0001849_ear_inflammation0.51231151

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)4.66698868
2Recurrent cutaneous fungal infections (HP:0011370)4.42672478
3Chronic mucocutaneous candidiasis (HP:0002728)4.42672478
4Recurrent abscess formation (HP:0002722)4.24100020
5Recurrent bacterial skin infections (HP:0005406)4.23048101
6Petechiae (HP:0000967)4.15753677
7Abnormality of liposaccharide metabolism (HP:0010968)4.09422239
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.09422239
9Abnormality of glycolipid metabolism (HP:0010969)4.09422239
10Eczematoid dermatitis (HP:0000976)4.07828719
11Recurrent gram-negative bacterial infections (HP:0005420)3.96838202
12Abnormality of fatty-acid metabolism (HP:0004359)3.80731241
13Vacuolated lymphocytes (HP:0001922)3.70282268
14Optic neuritis (HP:0100653)3.61191251
15Retrobulbar optic neuritis (HP:0100654)3.61191251
16Prolonged bleeding time (HP:0003010)3.49486210
17Meningitis (HP:0001287)3.48867985
18Abnormal platelet volume (HP:0011876)3.41313504
19Hypoglycemic coma (HP:0001325)3.33521511
20Purpura (HP:0000979)3.32913072
21Menorrhagia (HP:0000132)3.28877883
22Gastrointestinal infarctions (HP:0005244)3.26071429
23Increased mean platelet volume (HP:0011877)3.24049951
24Loss of speech (HP:0002371)3.21868188
25Recurrent viral infections (HP:0004429)3.21433668
26Stomatitis (HP:0010280)3.17923292
27IgM deficiency (HP:0002850)3.16327619
28Hemoptysis (HP:0002105)3.16123791
29Gingival bleeding (HP:0000225)3.14521525
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.09405430
31Vasculitis (HP:0002633)3.08454840
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.08445431
33Abnormality of macrophages (HP:0004311)3.04787729
34Generalized aminoaciduria (HP:0002909)3.02060405
35Epistaxis (HP:0000421)2.98106979
36Pulmonary infiltrates (HP:0002113)2.93758412
37Interstitial pulmonary disease (HP:0006530)2.93294900
38Autoimmune thrombocytopenia (HP:0001973)2.88709644
39Colitis (HP:0002583)2.88180194
40Premature loss of primary teeth (HP:0006323)2.81772614
41Hyperglycinuria (HP:0003108)2.79639467
42Increased cerebral lipofuscin (HP:0011813)2.79506130
43Impaired platelet aggregation (HP:0003540)2.76388309
44Abnormal platelet function (HP:0011869)2.76388309
45Increased IgE level (HP:0003212)2.73443261
46Myositis (HP:0100614)2.72268793
47Encephalitis (HP:0002383)2.70888103
48Pustule (HP:0200039)2.67438769
49Disinhibition (HP:0000734)2.66394561
50Inflammation of the large intestine (HP:0002037)2.65336892
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.58837642
52Dysostosis multiplex (HP:0000943)2.57371005
53Elevated erythrocyte sedimentation rate (HP:0003565)2.56322059
54Gastrointestinal inflammation (HP:0004386)2.53748418
55Joint hemorrhage (HP:0005261)2.53309941
56Mutism (HP:0002300)2.52301578
57Hyperammonemia (HP:0001987)2.51902830
58Spontaneous hematomas (HP:0007420)2.48933358
59Ketosis (HP:0001946)2.48889483
60Osteolytic defects of the hand bones (HP:0009699)2.48042726
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.48042726
62Increased IgM level (HP:0003496)2.46573234
63Keratoconjunctivitis sicca (HP:0001097)2.45914951
64Nausea (HP:0002018)2.45655144
65Multiple enchondromatosis (HP:0005701)2.45130022
66Recurrent skin infections (HP:0001581)2.44358343
67Abnormality of aromatic amino acid family metabolism (HP:0004338)2.43672367
68Mucopolysacchariduria (HP:0008155)2.43362357
69Urinary glycosaminoglycan excretion (HP:0003541)2.43362357
70Hypertriglyceridemia (HP:0002155)2.42419522
71Chest pain (HP:0100749)2.41656800
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39889108
73Dicarboxylic aciduria (HP:0003215)2.39889108
74Deep venous thrombosis (HP:0002625)2.39080997
75Urticaria (HP:0001025)2.38505923
76Myocardial infarction (HP:0001658)2.38476663
77Ketoacidosis (HP:0001993)2.38344043
78Spondylolisthesis (HP:0003302)2.37029509
79Cheilitis (HP:0100825)2.34128874
80Hand muscle atrophy (HP:0009130)2.30683006
81Panhypogammaglobulinemia (HP:0003139)2.30040069
82Keratoconjunctivitis (HP:0001096)2.29915612
83Abnormality of glycine metabolism (HP:0010895)2.29455893
84Abnormality of serine family amino acid metabolism (HP:0010894)2.29455893
85Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.29055725
86Cellulitis (HP:0100658)2.26809200
87Xanthomatosis (HP:0000991)2.26648862
88Polygenic inheritance (HP:0010982)2.24871793
89Abnormality of polysaccharide metabolism (HP:0011012)2.24712943
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24712943
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24712943
92Upper motor neuron abnormality (HP:0002127)2.23337192
93Agammaglobulinemia (HP:0004432)2.23266955
94Gingivitis (HP:0000230)2.21926437
95Gastrointestinal stroma tumor (HP:0100723)2.19602701
96Arterial thrombosis (HP:0004420)2.18628249
97Leukocytosis (HP:0001974)2.18615335
98Recurrent fungal infections (HP:0002841)2.18210173
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17932608
100Axonal loss (HP:0003447)2.17403690
101Hematochezia (HP:0002573)2.16136462
102Glomerulonephritis (HP:0000099)2.15299997
103Esophageal varix (HP:0002040)2.13719968
104T lymphocytopenia (HP:0005403)2.13650592
105Abnormality of T cell number (HP:0011839)2.12735341
106Malnutrition (HP:0004395)2.12717528
107Reduced subcutaneous adipose tissue (HP:0003758)2.12566256
108Hypergammaglobulinemia (HP:0010702)2.11762018
109Absent frontal sinuses (HP:0002688)2.11611653
110Distal upper limb amyotrophy (HP:0007149)2.11006817
111Upper limb amyotrophy (HP:0009129)2.11006817
112Hypoalphalipoproteinemia (HP:0003233)2.10852152
113Orchitis (HP:0100796)2.09498579
114Cerebral aneurysm (HP:0004944)2.09072048
115Rhabdomyolysis (HP:0003201)2.08497230
116Neuronal loss in central nervous system (HP:0002529)2.08139909
117Periodontitis (HP:0000704)2.07918378
118Myoglobinuria (HP:0002913)2.07453017
119Abnormality of the peritoneum (HP:0002585)2.04993701
120Abnormality of the pleura (HP:0002103)2.04454400
121Chronic otitis media (HP:0000389)2.02778939
122Restrictive lung disease (HP:0002091)2.02703265
123Protuberant abdomen (HP:0001538)2.00087277
124Abnormality of purine metabolism (HP:0004352)1.98643057
125Polyneuropathy (HP:0001271)1.96699172
126Basal ganglia calcification (HP:0002135)1.95699913
127Thoracic kyphosis (HP:0002942)1.93482942
128Abnormality of the endocardium (HP:0004306)1.92434422
129Hypertensive crisis (HP:0100735)1.91265143
130Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91241241
131Chronic obstructive pulmonary disease (HP:0006510)1.90569464
132Obstructive lung disease (HP:0006536)1.90569464
133Amaurosis fugax (HP:0100576)1.90335283
134Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.89537892
135Gangrene (HP:0100758)1.88719223
136Abnormality of T cells (HP:0002843)1.88542127
137Hyperlipoproteinemia (HP:0010980)1.88521741
138Abnormality of the vasculature of the conjunctiva (HP:0008054)1.88319220
139Increased serum ferritin (HP:0003281)1.87664379
140Abnormal cartilage morphology (HP:0002763)1.87098120
141Spastic diplegia (HP:0001264)1.86875257
142Mediastinal lymphadenopathy (HP:0100721)1.81668875
143Generalized amyotrophy (HP:0003700)1.79951689
144Toxemia of pregnancy (HP:0100603)1.79370484
145Proximal tubulopathy (HP:0000114)1.78461884
146Amyloidosis (HP:0011034)1.77202839
147Abnormality of the common coagulation pathway (HP:0010990)1.77196317
148Abnormality of the nasal mucosa (HP:0000433)1.75733214
149Ventricular tachycardia (HP:0004756)1.74991800
150Neonatal death (HP:0003811)1.74827721
151Osteomyelitis (HP:0002754)1.74760949
152Peritonitis (HP:0002586)1.73852570
153Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.73539743
154Pulmonary embolism (HP:0002204)1.73117284
155Thrombocytosis (HP:0001894)1.72659062
156Oligomenorrhea (HP:0000876)1.71387720
157Delayed CNS myelination (HP:0002188)1.70778780
158Gout (HP:0001997)1.70567211
159Hepatosplenomegaly (HP:0001433)1.69780964

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.23980215
2PKN23.67509699
3ERN13.51087797
4TRIB33.28447827
5MAP3K142.92465163
6PRPF4B2.83104930
7BCKDK2.71647474
8EPHB12.67959246
9MAP2K32.62479999
10TGFBR22.60800977
11MAP3K132.31477267
12BTK2.29152105
13LRRK22.25703024
14CAMK1D2.09612460
15STK102.02717804
16RIPK11.95509329
17TEC1.78016439
18FLT31.77283742
19TTN1.76021505
20TRPM71.72095325
21EEF2K1.69796399
22CDC42BPA1.68607910
23CSK1.68574361
24GRK71.66401061
25CSF1R1.65662784
26KIT1.51986966
27SIK11.50091402
28ZAP701.37663536
29TGFBR11.37485959
30TBK11.36875204
31IRAK31.34617173
32PAK41.34607436
33MAP2K41.33067760
34CAMKK21.31636751
35TIE11.31636443
36HCK1.30315571
37BLK1.30138619
38FGFR41.26962386
39TXK1.25409522
40FES1.20446267
41RPS6KA41.19656780
42MAP3K111.19007019
43PTK61.17146213
44TAOK21.14587918
45GRK61.11981693
46MATK1.10391580
47CAMK1G1.09793136
48DDR21.08387807
49FGR1.08315203
50RPS6KB21.08220127
51TYK21.07823921
52PIM21.05898319
53MAP3K101.05711004
54ITK1.01973420
55IRAK41.00877800
56KDR0.99534896
57JAK20.98122829
58MAP3K10.94323422
59RIPK40.91044772
60MAPK40.90314659
61TNK20.89815088
62JAK30.89379172
63PRKG20.88167359
64TAOK30.87606840
65SIK30.85998823
66ABL20.84750256
67MAPK70.81957805
68MOS0.81214248
69PIM10.79103378
70RET0.76916568
71CDK90.76492867
72MAP3K60.75005814
73SYK0.74832090
74SIK20.74598505
75KSR20.74140366
76RPS6KA60.71702734
77ILK0.71242119
78BMPR20.70491098
79CDK60.69811717
80YES10.69200407
81RPS6KC10.66613648
82RPS6KL10.66613648
83CDK70.66569026
84SMG10.66512681
85MST40.65820942
86IRAK10.64392095
87SCYL20.63632161
88MARK20.63519001
89IRAK20.63421993
90PDK10.63391452
91FGFR30.63097682
92MAP2K60.62444983
93MARK30.61757030
94RPS6KA20.60498499
95MAP3K50.60203758
96DAPK20.59572892
97TESK20.58942462
98MYLK0.58555048
99PDPK10.56765785
100MAPK120.56207772
101CHUK0.55888843
102PRKD20.55271562
103PRKCQ0.55071732
104ADRBK20.53292602
105ALK0.52879458
106ACVR1B0.51976104
107HIPK20.49376060
108FYN0.48715183
109PIK3CG0.48001266
110LYN0.47939381
111ARAF0.47456743
112CAMKK10.46873556
113PAK20.46193899
114EPHA30.45627844
115JAK10.45375408
116ABL10.45370491
117PRKAA20.44421046
118MAP3K30.44067506
119MAPKAPK20.40606691
120MAPKAPK30.40149999
121GSK3A0.39831918
122TAOK10.39404192
123BRSK20.38006098
124SGK30.37478915
125LCK0.35841496
126CDK120.34915275
127NME20.33668573
128MAP3K80.33115582
129EGFR0.32931387
130IKBKB0.32879106
131MAP3K70.32837106
132CDK40.31802499
133NEK90.30435005
134PTK2B0.30043350
135IKBKE0.29691237
136PTK20.29103624

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.20770082
2Autoimmune thyroid disease_Homo sapiens_hsa053202.91481961
3Graft-versus-host disease_Homo sapiens_hsa053322.90540889
4Fatty acid degradation_Homo sapiens_hsa000712.89291631
5Asthma_Homo sapiens_hsa053102.80474884
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.69339813
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57655549
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.54800205
9Fatty acid metabolism_Homo sapiens_hsa012122.53187621
10Propanoate metabolism_Homo sapiens_hsa006402.44447356
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.38198342
12Type I diabetes mellitus_Homo sapiens_hsa049402.35579877
13PPAR signaling pathway_Homo sapiens_hsa033202.29895255
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24858851
15Staphylococcus aureus infection_Homo sapiens_hsa051502.10904589
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09277317
17Antigen processing and presentation_Homo sapiens_hsa046122.00686917
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98029214
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96603993
20Fatty acid elongation_Homo sapiens_hsa000621.93138744
21Caffeine metabolism_Homo sapiens_hsa002321.92228190
22Leishmaniasis_Homo sapiens_hsa051401.88964810
23Influenza A_Homo sapiens_hsa051641.86357889
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.76042416
25Peroxisome_Homo sapiens_hsa041461.71138601
26Carbon metabolism_Homo sapiens_hsa012001.65910575
27beta-Alanine metabolism_Homo sapiens_hsa004101.65290050
28Nitrogen metabolism_Homo sapiens_hsa009101.60047873
29Measles_Homo sapiens_hsa051621.58724156
30Primary immunodeficiency_Homo sapiens_hsa053401.55492469
31Complement and coagulation cascades_Homo sapiens_hsa046101.54189686
32Osteoclast differentiation_Homo sapiens_hsa043801.53399330
33Chemokine signaling pathway_Homo sapiens_hsa040621.48339429
34Herpes simplex infection_Homo sapiens_hsa051681.47350825
35Legionellosis_Homo sapiens_hsa051341.47304516
36Other glycan degradation_Homo sapiens_hsa005111.44221427
37Starch and sucrose metabolism_Homo sapiens_hsa005001.41804833
38Pentose phosphate pathway_Homo sapiens_hsa000301.36104769
39Histidine metabolism_Homo sapiens_hsa003401.35642607
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.35128280
41Lysosome_Homo sapiens_hsa041421.35027636
42Arginine biosynthesis_Homo sapiens_hsa002201.34860020
43Pyruvate metabolism_Homo sapiens_hsa006201.31634536
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.29471935
45Tryptophan metabolism_Homo sapiens_hsa003801.25494672
46Platelet activation_Homo sapiens_hsa046111.25339576
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24351516
48Shigellosis_Homo sapiens_hsa051311.24287308
49Acute myeloid leukemia_Homo sapiens_hsa052211.14493463
50Tuberculosis_Homo sapiens_hsa051521.12794274
51Butanoate metabolism_Homo sapiens_hsa006501.11816186
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11028764
53Pertussis_Homo sapiens_hsa051331.09114909
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09026983
55Biosynthesis of amino acids_Homo sapiens_hsa012301.07109234
56Hepatitis C_Homo sapiens_hsa051601.06533834
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05529501
58B cell receptor signaling pathway_Homo sapiens_hsa046621.04329335
59T cell receptor signaling pathway_Homo sapiens_hsa046601.02493378
60African trypanosomiasis_Homo sapiens_hsa051431.02093451
61Insulin resistance_Homo sapiens_hsa049311.01562582
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00896446
63Hematopoietic cell lineage_Homo sapiens_hsa046401.00853346
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.98194500
65Lysine degradation_Homo sapiens_hsa003100.95368338
66Malaria_Homo sapiens_hsa051440.93793744
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93172619
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92546623
69Glycerolipid metabolism_Homo sapiens_hsa005610.90429841
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89849782
71Salmonella infection_Homo sapiens_hsa051320.84936368
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84779945
73ABC transporters_Homo sapiens_hsa020100.83028930
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82222663
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81313142
76Retinol metabolism_Homo sapiens_hsa008300.80899780
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80575709
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.79956573
79Toxoplasmosis_Homo sapiens_hsa051450.79864689
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78781532
81Epstein-Barr virus infection_Homo sapiens_hsa051690.77651710
82Chronic myeloid leukemia_Homo sapiens_hsa052200.76892741
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.73493734
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73049810
85Prolactin signaling pathway_Homo sapiens_hsa049170.72580853
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71636555
87Folate biosynthesis_Homo sapiens_hsa007900.68671413
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68163345
89Viral myocarditis_Homo sapiens_hsa054160.68083709
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67013968
91Chemical carcinogenesis_Homo sapiens_hsa052040.64613698
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64086833
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64064651
94Fatty acid biosynthesis_Homo sapiens_hsa000610.63503297
95Glutathione metabolism_Homo sapiens_hsa004800.63098274
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63093989
97Galactose metabolism_Homo sapiens_hsa000520.61461374
98Apoptosis_Homo sapiens_hsa042100.59752514
99Pancreatic cancer_Homo sapiens_hsa052120.59461189
100VEGF signaling pathway_Homo sapiens_hsa043700.59395976
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58980445
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57215370
103Phagosome_Homo sapiens_hsa041450.56907979
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55430601
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.55413579
106Phenylalanine metabolism_Homo sapiens_hsa003600.55338350
107Hepatitis B_Homo sapiens_hsa051610.55095953
108AMPK signaling pathway_Homo sapiens_hsa041520.54688632
109HTLV-I infection_Homo sapiens_hsa051660.54330953
110Fat digestion and absorption_Homo sapiens_hsa049750.53494289
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52946353
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.52390655
113Non-small cell lung cancer_Homo sapiens_hsa052230.51487926
114TNF signaling pathway_Homo sapiens_hsa046680.49156628
115Thyroid cancer_Homo sapiens_hsa052160.48675205
116Vitamin digestion and absorption_Homo sapiens_hsa049770.48100788
117Amoebiasis_Homo sapiens_hsa051460.47142130
118ECM-receptor interaction_Homo sapiens_hsa045120.47101040
119Bile secretion_Homo sapiens_hsa049760.46240014
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.45847720
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45261105
122Endocytosis_Homo sapiens_hsa041440.45148463
123Bladder cancer_Homo sapiens_hsa052190.44900558
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44464110
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43289135
126Rheumatoid arthritis_Homo sapiens_hsa053230.43259521
127Renal cell carcinoma_Homo sapiens_hsa052110.43258148
128Type II diabetes mellitus_Homo sapiens_hsa049300.43193217
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.42521622
130Collecting duct acid secretion_Homo sapiens_hsa049660.41920500
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.40652875
132Arginine and proline metabolism_Homo sapiens_hsa003300.40477700
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40290406
134GnRH signaling pathway_Homo sapiens_hsa049120.40081515
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40008493
136Insulin signaling pathway_Homo sapiens_hsa049100.39988040
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39698709
138Notch signaling pathway_Homo sapiens_hsa043300.38369750
139Prion diseases_Homo sapiens_hsa050200.37224696
140Viral carcinogenesis_Homo sapiens_hsa052030.36853324
141Systemic lupus erythematosus_Homo sapiens_hsa053220.35356430
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33792539
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33673637
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33536998
145HIF-1 signaling pathway_Homo sapiens_hsa040660.31717871
146Dorso-ventral axis formation_Homo sapiens_hsa043200.25982832
147MAPK signaling pathway_Homo sapiens_hsa040100.24825455
148FoxO signaling pathway_Homo sapiens_hsa040680.22113435
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21530468
150Choline metabolism in cancer_Homo sapiens_hsa052310.20281869
151Estrogen signaling pathway_Homo sapiens_hsa049150.20154408
152mTOR signaling pathway_Homo sapiens_hsa041500.19328939
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18373989

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