RUNDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.89356379
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.07474086
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.91778448
4synaptic vesicle maturation (GO:0016188)4.91443983
5regulation of synapse structural plasticity (GO:0051823)4.61535739
6L-fucose catabolic process (GO:0042355)4.56503319
7fucose catabolic process (GO:0019317)4.56503319
8L-fucose metabolic process (GO:0042354)4.56503319
9locomotory exploration behavior (GO:0035641)4.55944715
10synaptic vesicle exocytosis (GO:0016079)4.24329353
11COPI coating of Golgi vesicle (GO:0048205)4.23414597
12Golgi transport vesicle coating (GO:0048200)4.23414597
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.11267468
14positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.07203499
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.06977392
16activation of protein kinase A activity (GO:0034199)4.05972165
17sodium ion export (GO:0071436)3.89997156
18glutamate secretion (GO:0014047)3.88970424
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.88205179
20vocalization behavior (GO:0071625)3.86819353
21epithelial cilium movement (GO:0003351)3.85586383
22regulation of synaptic vesicle exocytosis (GO:2000300)3.85140207
23pyrimidine nucleobase catabolic process (GO:0006208)3.61028187
24regulation of neuronal synaptic plasticity (GO:0048168)3.60643997
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59660075
26axoneme assembly (GO:0035082)3.54520622
27regulation of glutamate receptor signaling pathway (GO:1900449)3.53477244
28regulation of hexokinase activity (GO:1903299)3.52503562
29regulation of glucokinase activity (GO:0033131)3.52503562
30positive regulation of synapse maturation (GO:0090129)3.52045383
31layer formation in cerebral cortex (GO:0021819)3.51809683
32regulation of synaptic vesicle transport (GO:1902803)3.51181650
33negative regulation of telomere maintenance (GO:0032205)3.47053279
34neurotransmitter secretion (GO:0007269)3.44052131
35cellular potassium ion homeostasis (GO:0030007)3.40493083
36cornea development in camera-type eye (GO:0061303)3.37783510
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.37468109
38regulation of ARF protein signal transduction (GO:0032012)3.35623633
39protein K11-linked deubiquitination (GO:0035871)3.33194815
40exploration behavior (GO:0035640)3.31326130
41cilium movement (GO:0003341)3.28822026
42cilium or flagellum-dependent cell motility (GO:0001539)3.28613095
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.27361244
44glycine transport (GO:0015816)3.25592319
45axonemal dynein complex assembly (GO:0070286)3.24333469
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.24178919
47indolalkylamine metabolic process (GO:0006586)3.23926327
48indole-containing compound catabolic process (GO:0042436)3.23099035
49indolalkylamine catabolic process (GO:0046218)3.23099035
50tryptophan catabolic process (GO:0006569)3.23099035
51protein polyglutamylation (GO:0018095)3.19194555
52kynurenine metabolic process (GO:0070189)3.19031718
53limb bud formation (GO:0060174)3.17779076
54G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.17657682
55glycerophospholipid catabolic process (GO:0046475)3.17345468
56nucleobase catabolic process (GO:0046113)3.16043483
57neuromuscular process controlling balance (GO:0050885)3.15889282
58adenosine receptor signaling pathway (GO:0001973)3.15470096
59cell communication by electrical coupling (GO:0010644)3.14950063
60membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.14420614
61dendritic spine morphogenesis (GO:0060997)3.12995810
62prepulse inhibition (GO:0060134)3.11836149
63membrane repolarization (GO:0086009)3.10046442
64ionotropic glutamate receptor signaling pathway (GO:0035235)3.09825747
65kidney morphogenesis (GO:0060993)3.09291407
66retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.08718890
67negative regulation of mast cell activation (GO:0033004)3.05060624
68chemosensory behavior (GO:0007635)3.04730816
69positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.04313154
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02000645
71cellular sodium ion homeostasis (GO:0006883)3.01954302
72proline transport (GO:0015824)3.01704580
73detection of light stimulus involved in visual perception (GO:0050908)2.99877955
74detection of light stimulus involved in sensory perception (GO:0050962)2.99877955
75regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.99457427
76regulation of action potential (GO:0098900)2.99111836
77cerebellar Purkinje cell layer development (GO:0021680)2.97493681
78regulation of synaptic plasticity (GO:0048167)2.97349327
79regulation of telomere maintenance (GO:0032204)2.96469483
80cellular response to ATP (GO:0071318)2.95975521
81protein localization to synapse (GO:0035418)2.95490411
82positive regulation of membrane potential (GO:0045838)2.94223281
83neuromuscular process controlling posture (GO:0050884)2.92465023
84nonmotile primary cilium assembly (GO:0035058)2.92122071
85cellular response to glucagon stimulus (GO:0071377)2.91460541
86regulation of ARF GTPase activity (GO:0032312)2.88167785
87gamma-aminobutyric acid transport (GO:0015812)2.88073323
88long-term memory (GO:0007616)2.87219011
89nephron tubule morphogenesis (GO:0072078)2.85234854
90nephron epithelium morphogenesis (GO:0072088)2.85234854
91cellular ketone body metabolic process (GO:0046950)2.84444366
92preassembly of GPI anchor in ER membrane (GO:0016254)2.83920886
93regulation of cilium movement (GO:0003352)2.83569234
94auditory behavior (GO:0031223)2.83260046
95synaptic transmission, glutamatergic (GO:0035249)2.83011813
96cytoskeletal anchoring at plasma membrane (GO:0007016)2.83010841
97DNA deamination (GO:0045006)2.82963678
98potassium ion import (GO:0010107)2.82609985
99startle response (GO:0001964)2.78946842
100protein localization to cilium (GO:0061512)2.78914518
101regulation of hippo signaling (GO:0035330)2.78168888
102piRNA metabolic process (GO:0034587)2.76956577
103regulation of calcium ion-dependent exocytosis (GO:0017158)2.76716129
104membrane repolarization during action potential (GO:0086011)2.76122513
105striatum development (GO:0021756)2.75347468
106dendritic spine organization (GO:0097061)2.71413719
107detection of calcium ion (GO:0005513)2.71073830
108signal complex assembly (GO:0007172)2.70738348
109response to auditory stimulus (GO:0010996)2.70605307
110thyroid hormone metabolic process (GO:0042403)2.69708918
111synaptic transmission, cholinergic (GO:0007271)2.69140263
112neural tube formation (GO:0001841)2.68846164
113cilium organization (GO:0044782)2.68389827
114dendrite morphogenesis (GO:0048813)2.68343409
115regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.68007463
116positive regulation of CREB transcription factor activity (GO:0032793)2.67993942
117regulation of excitatory postsynaptic membrane potential (GO:0060079)2.66246008
118water-soluble vitamin biosynthetic process (GO:0042364)2.66008250
119adaptation of signaling pathway (GO:0023058)2.64497253
120positive regulation of sodium ion transmembrane transport (GO:1902307)2.63449517
121behavioral defense response (GO:0002209)2.63411060
122behavioral fear response (GO:0001662)2.63411060
123detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62896515
124adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.61171323
125endocrine pancreas development (GO:0031018)2.60562005
126protein maturation by protein folding (GO:0022417)2.60017073
127cilium assembly (GO:0042384)2.59861984
128membrane depolarization during action potential (GO:0086010)2.59277855
129neuronal action potential propagation (GO:0019227)2.58296399
130positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.57968236
131glutamate receptor signaling pathway (GO:0007215)2.57341984
132nerve growth factor signaling pathway (GO:0038180)2.57333347
133cilium morphogenesis (GO:0060271)2.57324546
134cAMP catabolic process (GO:0006198)2.57251129
135positive regulation of synaptic transmission, GABAergic (GO:0032230)2.56067720
136DNA methylation involved in gamete generation (GO:0043046)2.55016049
137fucosylation (GO:0036065)2.54244155
138platelet dense granule organization (GO:0060155)2.53837432
139vesicle transport along microtubule (GO:0047496)2.52779746
140potassium ion homeostasis (GO:0055075)2.52271303
141neuron-neuron synaptic transmission (GO:0007270)2.51477553
142dopamine receptor signaling pathway (GO:0007212)2.50916025
143regulation of vesicle fusion (GO:0031338)2.50910067
144limb development (GO:0060173)2.50542090
145appendage development (GO:0048736)2.50542090
146neurofilament cytoskeleton organization (GO:0060052)2.50304602
147cAMP biosynthetic process (GO:0006171)2.50273716
148long-term synaptic potentiation (GO:0060291)2.49341751
149indole-containing compound metabolic process (GO:0042430)2.48931242
150neurotransmitter transport (GO:0006836)2.48861137
151primary amino compound metabolic process (GO:1901160)2.48541181
152retinal ganglion cell axon guidance (GO:0031290)2.48216271
153snRNA transcription (GO:0009301)2.47867876
154alanine transport (GO:0032328)2.47837639
155neuronal ion channel clustering (GO:0045161)2.47182518
156amine catabolic process (GO:0009310)2.47056893
157cellular biogenic amine catabolic process (GO:0042402)2.47056893
158positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46523107
159positive regulation of vesicle fusion (GO:0031340)2.46229971
160neurotransmitter-gated ion channel clustering (GO:0072578)2.45961994
161regulation of dendritic spine morphogenesis (GO:0061001)2.45623653
162catecholamine transport (GO:0051937)2.45375757
163regulation of postsynaptic membrane potential (GO:0060078)2.45368386
164cerebellar Purkinje cell differentiation (GO:0021702)2.44869619
165regulation of microtubule-based movement (GO:0060632)2.44618663
166regulation of neurotransmitter levels (GO:0001505)2.44524048
167postsynaptic membrane organization (GO:0001941)2.43704613
168behavioral response to ethanol (GO:0048149)2.43702524
169positive regulation of potassium ion transmembrane transport (GO:1901381)2.42079455
170vesicle coating (GO:0006901)2.41500165
171spinal cord development (GO:0021510)2.41228338
172protein complex biogenesis (GO:0070271)2.41016395
173neuromuscular process (GO:0050905)2.40359624
174regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40295835
175fear response (GO:0042596)2.40242318
176mechanosensory behavior (GO:0007638)2.39756800
177regulation of type B pancreatic cell apoptotic process (GO:2000674)2.38558502
178neurotransmitter metabolic process (GO:0042133)2.38156093
179ketone body metabolic process (GO:1902224)2.37801193
180protein-cofactor linkage (GO:0018065)2.37724496
181tryptophan metabolic process (GO:0006568)2.36562002
182retina layer formation (GO:0010842)2.34330903
183neuronal action potential (GO:0019228)2.31858352
184rRNA catabolic process (GO:0016075)2.31715292
185alkaloid metabolic process (GO:0009820)2.31442525
186positive regulation of fatty acid transport (GO:2000193)2.30739310
187microtubule bundle formation (GO:0001578)2.28177425
188somite development (GO:0061053)2.28136593
189response to pheromone (GO:0019236)2.26949569
190left/right pattern formation (GO:0060972)2.26133819

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.28257001
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.21006933
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.97828636
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.73529691
5GBX2_23144817_ChIP-Seq_PC3_Human2.60906107
6VDR_22108803_ChIP-Seq_LS180_Human2.55288685
7DROSHA_22980978_ChIP-Seq_HELA_Human2.51375603
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42461130
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42183105
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.42064624
11REST_21632747_ChIP-Seq_MESCs_Mouse2.35865726
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29995085
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25392497
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25015338
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.21442982
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19753999
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11026928
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10877097
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10877097
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09206302
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06978361
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.05191822
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04800179
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03252029
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.03217856
26DNAJC2_21179169_ChIP-ChIP_NT2_Human2.02197287
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.01659746
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00768347
29LXR_22292898_ChIP-Seq_THP-1_Human1.97599499
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96490932
31KDM2B_26808549_Chip-Seq_K562_Human1.94219312
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.93246471
33EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.91202615
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.91092389
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89544620
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89127881
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87373233
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84042881
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79532702
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79294692
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.78903534
42ER_23166858_ChIP-Seq_MCF-7_Human1.73309492
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.72936817
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.72847192
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.72787017
46KDM2B_26808549_Chip-Seq_DND41_Human1.71022570
47GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67083205
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.66013580
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63993905
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62136186
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62136186
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59958356
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.51996195
54P300_19829295_ChIP-Seq_ESCs_Human1.50788322
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50435771
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50157693
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47978322
58ZNF263_19887448_ChIP-Seq_K562_Human1.47377327
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45463423
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44958635
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44326772
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44160298
63CREB1_26743006_Chip-Seq_LNCaP_Human1.44034370
64TP53_22573176_ChIP-Seq_HFKS_Human1.43593467
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.43213805
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.41265719
67FUS_26573619_Chip-Seq_HEK293_Human1.40876281
68IRF1_19129219_ChIP-ChIP_H3396_Human1.38671343
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38421096
70MYC_22102868_ChIP-Seq_BL_Human1.38407686
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38381992
72STAT3_23295773_ChIP-Seq_U87_Human1.37986129
73AR_25329375_ChIP-Seq_VCAP_Human1.37077230
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36557248
75IGF1R_20145208_ChIP-Seq_DFB_Human1.36375945
76BCAT_22108803_ChIP-Seq_LS180_Human1.36251727
77TCF4_23295773_ChIP-Seq_U87_Human1.32148281
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31634862
79SMAD4_21799915_ChIP-Seq_A2780_Human1.31623217
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.30530501
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29978289
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29550445
83SMC4_20622854_ChIP-Seq_HELA_Human1.29241476
84CTCF_27219007_Chip-Seq_Bcells_Human1.29214701
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29135544
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27997199
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27312980
88TAF15_26573619_Chip-Seq_HEK293_Human1.27272535
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26778167
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26489298
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25250022
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22932159
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22201586
94TET1_21490601_ChIP-Seq_MESCs_Mouse1.22108872
95RNF2_27304074_Chip-Seq_NSC_Mouse1.21214244
96TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.21038353
97* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20361860
98EWS_26573619_Chip-Seq_HEK293_Human1.19685115
99AHR_22903824_ChIP-Seq_MCF-7_Human1.19496862
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.18594238
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18276351
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17333031
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17129233
104RACK7_27058665_Chip-Seq_MCF-7_Human1.15707265
105TCF7_22412390_ChIP-Seq_EML_Mouse1.14979910
106P68_20966046_ChIP-Seq_HELA_Human1.14744032
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.14261170
108TCF4_22108803_ChIP-Seq_LS180_Human1.13737352
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.12951165
110RUNX2_22187159_ChIP-Seq_PCA_Human1.12883519
111EED_16625203_ChIP-ChIP_MESCs_Mouse1.12416502
112CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12214348
113CBP_20019798_ChIP-Seq_JUKART_Human1.11565092
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11565092
115ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10148899
116NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10107777
117AR_19668381_ChIP-Seq_PC3_Human1.08166489
118ERA_21632823_ChIP-Seq_H3396_Human1.08143939
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08136948
120HOXB7_26014856_ChIP-Seq_BT474_Human1.08076589
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06814947
122FLI1_27457419_Chip-Seq_LIVER_Mouse1.05959923
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.05087195
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04653291
125RUNX1_27514584_Chip-Seq_MCF-7_Human1.04102840
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03992597
127GATA3_21878914_ChIP-Seq_MCF-7_Human1.03773187
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03664173
129FOXA1_25329375_ChIP-Seq_VCAP_Human1.03664173
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03263100
131NCOR_22424771_ChIP-Seq_293T_Human1.02501359
132PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01803361
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00740379
134P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00384582
135MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99856368
136TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99008449
137KLF4_19829295_ChIP-Seq_ESCs_Human0.98971463
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.98525083
139AR_21572438_ChIP-Seq_LNCaP_Human0.97843438
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97840599
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97576656
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95827254
143STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95294333
144PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94996842
145ZNF274_21170338_ChIP-Seq_K562_Hela0.94658781
146FLI1_21867929_ChIP-Seq_TH2_Mouse0.93935063
147SOX2_21211035_ChIP-Seq_LN229_Gbm0.93315537
148FOXA2_19822575_ChIP-Seq_HepG2_Human0.93067310
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93001511
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92858943
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92033376
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91996509
153NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91896045
154GATA1_19941826_ChIP-Seq_K562_Human0.91706183
155BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91124842
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90956695
157KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90650125
158SMAD3_21741376_ChIP-Seq_ESCs_Human0.90198120
159STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.88924464
160* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.88054339
161TP63_22573176_ChIP-Seq_HFKS_Human0.87997297
162* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86426460
163OCT4_19829295_ChIP-Seq_ESCs_Human0.85962144
164SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85335761
165SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85211381
166ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84970964
167ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84673699
168ELF1_20517297_ChIP-Seq_JURKAT_Human0.84304631
169GATA1_19941827_ChIP-Seq_MEL_Mouse0.84102171
170RING1B_27294783_Chip-Seq_NPCs_Mouse0.83822466
171RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83672598
172SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82836073
173ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.82607144
174SA1_27219007_Chip-Seq_Bcells_Human0.80777793
175* TET1_21451524_ChIP-Seq_MESCs_Mouse0.80190418
176UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80042578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.00957493
2MP0008961_abnormal_basal_metabolism3.67736469
3MP0002822_catalepsy3.56034076
4MP0003635_abnormal_synaptic_transmissio3.45031185
5MP0002909_abnormal_adrenal_gland3.28914924
6MP0004270_analgesia3.12336489
7MP0008877_abnormal_DNA_methylation2.80582150
8MP0002063_abnormal_learning/memory/cond2.68119470
9MP0009745_abnormal_behavioral_response2.62479292
10MP0003283_abnormal_digestive_organ2.60534075
11MP0000013_abnormal_adipose_tissue2.47903977
12MP0002064_seizures2.43809151
13MP0009780_abnormal_chondrocyte_physiolo2.42053617
14MP0004043_abnormal_pH_regulation2.24231460
15MP0006292_abnormal_olfactory_placode2.18025898
16MP0004858_abnormal_nervous_system2.15921450
17MP0003329_amyloid_beta_deposits2.11657774
18MP0005551_abnormal_eye_electrophysiolog2.10816789
19MP0002876_abnormal_thyroid_physiology2.10617689
20MP0002572_abnormal_emotion/affect_behav2.09407887
21MP0004133_heterotaxia2.05694481
22MP0003879_abnormal_hair_cell1.98209962
23MP0008872_abnormal_physiological_respon1.88113656
24MP0003880_abnormal_central_pattern1.79720358
25MP0001486_abnormal_startle_reflex1.79242587
26MP0004742_abnormal_vestibular_system1.75898724
27MP0005423_abnormal_somatic_nervous1.73474319
28MP0010234_abnormal_vibrissa_follicle1.71649966
29MP0003121_genomic_imprinting1.71024627
30MP0002102_abnormal_ear_morphology1.70057337
31MP0002733_abnormal_thermal_nociception1.68491594
32MP0002734_abnormal_mechanical_nocicepti1.67900594
33MP0000631_abnormal_neuroendocrine_gland1.66552482
34MP0001968_abnormal_touch/_nociception1.65464629
35MP0008569_lethality_at_weaning1.61397086
36MP0002234_abnormal_pharynx_morphology1.59866873
37MP0003300_gastrointestinal_ulcer1.59860383
38MP0003011_delayed_dark_adaptation1.59314729
39MP0009046_muscle_twitch1.58727855
40MP0002272_abnormal_nervous_system1.56709318
41MP0004811_abnormal_neuron_physiology1.55694180
42MP0006072_abnormal_retinal_apoptosis1.55612203
43MP0003136_yellow_coat_color1.55159506
44MP0003183_abnormal_peptide_metabolism1.55054051
45MP0002653_abnormal_ependyma_morphology1.52166939
46MP0001501_abnormal_sleep_pattern1.51081032
47MP0001970_abnormal_pain_threshold1.49766182
48MP0000003_abnormal_adipose_tissue1.48731064
49MP0004885_abnormal_endolymph1.47895882
50MP0001986_abnormal_taste_sensitivity1.45697306
51MP0001944_abnormal_pancreas_morphology1.41252001
52MP0002928_abnormal_bile_duct1.40746612
53MP0003172_abnormal_lysosome_physiology1.39139087
54MP0002693_abnormal_pancreas_physiology1.39090696
55MP0001440_abnormal_grooming_behavior1.37180507
56MP0002557_abnormal_social/conspecific_i1.35876827
57MP0004233_abnormal_muscle_weight1.33294675
58MP0005365_abnormal_bile_salt1.31196291
59MP0005377_hearing/vestibular/ear_phenot1.29712141
60MP0003878_abnormal_ear_physiology1.29712141
61MP0004510_myositis1.29248644
62MP0004142_abnormal_muscle_tone1.28141841
63MP0000427_abnormal_hair_cycle1.28062716
64MP0001765_abnormal_ion_homeostasis1.26052894
65MP0000955_abnormal_spinal_cord1.25641006
66MP0005083_abnormal_biliary_tract1.25449108
67MP0008875_abnormal_xenobiotic_pharmacok1.24495104
68MP0001529_abnormal_vocalization1.24199882
69MP0004924_abnormal_behavior1.23607499
70MP0005386_behavior/neurological_phenoty1.23607499
71MP0003075_altered_response_to1.22333011
72MP0005253_abnormal_eye_physiology1.21228494
73MP0002184_abnormal_innervation1.21224861
74MP0002078_abnormal_glucose_homeostasis1.20847213
75MP0006276_abnormal_autonomic_nervous1.20137546
76MP0003633_abnormal_nervous_system1.19723352
77MP0002067_abnormal_sensory_capabilities1.16614556
78MP0002837_dystrophic_cardiac_calcinosis1.16274476
79MP0004130_abnormal_muscle_cell1.12942736
80MP0004145_abnormal_muscle_electrophysio1.12925924
81MP0002277_abnormal_respiratory_mucosa1.12345850
82MP0002229_neurodegeneration1.11831216
83MP0000604_amyloidosis1.11402244
84MP0001984_abnormal_olfaction1.11121638
85MP0005174_abnormal_tail_pigmentation1.10472509
86MP0003122_maternal_imprinting1.09994090
87MP0001905_abnormal_dopamine_level1.08890496
88MP0004147_increased_porphyrin_level1.08557891
89MP0002163_abnormal_gland_morphology1.08071657
90MP0001502_abnormal_circadian_rhythm1.08017300
91MP0008789_abnormal_olfactory_epithelium1.07450385
92MP0005646_abnormal_pituitary_gland1.07346976
93MP0002069_abnormal_eating/drinking_beha1.06520182
94MP0000778_abnormal_nervous_system1.05501825
95MP0005535_abnormal_body_temperature1.05200839
96MP0002736_abnormal_nociception_after1.04398904
97MP0001666_abnormal_nutrient_absorption1.03531412
98MP0002066_abnormal_motor_capabilities/c1.02881495
99MP0002882_abnormal_neuron_morphology1.02683052
100MP0003303_peritoneal_inflammation1.02677053
101MP0002735_abnormal_chemical_nociception1.02335273
102MP0000751_myopathy1.01696011
103MP0005379_endocrine/exocrine_gland_phen0.99531590
104MP0005075_abnormal_melanosome_morpholog0.98894164
105MP0005084_abnormal_gallbladder_morpholo0.98121996
106MP0005187_abnormal_penis_morphology0.97992196
107MP0003938_abnormal_ear_development0.96278239
108MP0009840_abnormal_foam_cell0.94026589
109MP0004019_abnormal_vitamin_homeostasis0.92938246
110MP0005448_abnormal_energy_balance0.92930836
111MP0008874_decreased_physiological_sensi0.92542253
112MP0005499_abnormal_olfactory_system0.90370875
113MP0005394_taste/olfaction_phenotype0.90370875
114MP0002254_reproductive_system_inflammat0.90305588
115MP0001485_abnormal_pinna_reflex0.90236030
116MP0002752_abnormal_somatic_nervous0.90133913
117MP0002089_abnormal_postnatal_growth/wei0.90062071
118MP0000026_abnormal_inner_ear0.89866028
119MP0001963_abnormal_hearing_physiology0.89550612
120MP0002938_white_spotting0.89338662
121MP0005058_abnormal_lysosome_morphology0.88821260
122MP0001664_abnormal_digestion0.88720127
123MP0003953_abnormal_hormone_level0.87903610
124MP0002877_abnormal_melanocyte_morpholog0.87474755
125MP0002152_abnormal_brain_morphology0.87022291
126MP0005220_abnormal_exocrine_pancreas0.86828404
127MP0005375_adipose_tissue_phenotype0.86775233
128MP0000383_abnormal_hair_follicle0.86724472
129MP0003646_muscle_fatigue0.86571915
130MP0005645_abnormal_hypothalamus_physiol0.85791921
131MP0000747_muscle_weakness0.85706908
132MP0002751_abnormal_autonomic_nervous0.84266108
133MP0003890_abnormal_embryonic-extraembry0.83974150
134MP0003631_nervous_system_phenotype0.83478228
135MP0002090_abnormal_vision0.81753507
136MP0005195_abnormal_posterior_eye0.81569432
137MP0003195_calcinosis0.80657609
138MP0003634_abnormal_glial_cell0.80093148
139MP0003045_fibrosis0.77248776
140MP0002638_abnormal_pupillary_reflex0.76130426
141MP0003123_paternal_imprinting0.74705023
142MP0003866_abnormal_defecation0.74395341
143MP0000569_abnormal_digit_pigmentation0.74148577
144MP0003787_abnormal_imprinting0.72964225
145MP0010329_abnormal_lipoprotein_level0.70516271
146MP0004085_abnormal_heartbeat0.69530072
147MP0001756_abnormal_urination0.68708052

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)4.51979763
2Abnormality of midbrain morphology (HP:0002418)4.51979763
3Myokymia (HP:0002411)4.50584494
4Pancreatic cysts (HP:0001737)4.05066030
5Nephronophthisis (HP:0000090)3.95302699
6Visual hallucinations (HP:0002367)3.92768377
7Pancreatic fibrosis (HP:0100732)3.88453509
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.73909258
9Hyperventilation (HP:0002883)3.64151632
10True hermaphroditism (HP:0010459)3.60226936
11Focal motor seizures (HP:0011153)3.37950242
12Abnormality of the renal medulla (HP:0100957)3.29452580
13Congenital stationary night blindness (HP:0007642)3.23454025
14Abnormality of the lower motor neuron (HP:0002366)3.18055719
15Tubular atrophy (HP:0000092)3.15024725
16Type II lissencephaly (HP:0007260)3.11647126
17Focal seizures (HP:0007359)3.08859638
18Abnormal social behavior (HP:0012433)3.03933913
19Impaired social interactions (HP:0000735)3.03933913
20Chronic hepatic failure (HP:0100626)3.03867393
21Depression (HP:0000716)3.01432591
22Decreased circulating renin level (HP:0003351)2.97017896
23Upper limb amyotrophy (HP:0009129)2.95068854
24Distal upper limb amyotrophy (HP:0007149)2.95068854
25Abnormal drinking behavior (HP:0030082)2.91450727
26Polydipsia (HP:0001959)2.91450727
27Ankle clonus (HP:0011448)2.90096439
28Cystic liver disease (HP:0006706)2.90045208
29Gout (HP:0001997)2.89264526
30Increased circulating renin level (HP:0000848)2.87042635
31Abnormality of the renal cortex (HP:0011035)2.86941359
32Medial flaring of the eyebrow (HP:0010747)2.83572335
33Megalencephaly (HP:0001355)2.83373053
34Absent/shortened dynein arms (HP:0200106)2.79753284
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.79753284
36Lissencephaly (HP:0001339)2.75061162
37Poor eye contact (HP:0000817)2.74785255
38Febrile seizures (HP:0002373)2.74479498
39Supranuclear gaze palsy (HP:0000605)2.74018580
40Hand muscle atrophy (HP:0009130)2.68223564
41Papilledema (HP:0001085)2.67478720
42Truncal ataxia (HP:0002078)2.66716080
43Macroorchidism (HP:0000053)2.66602322
44Ketoacidosis (HP:0001993)2.64544946
45Hyperinsulinemic hypoglycemia (HP:0000825)2.62628992
46Ankyloglossia (HP:0010296)2.60154125
47Hypoglycemic seizures (HP:0002173)2.59304924
48Abnormal respiratory motile cilium morphology (HP:0005938)2.56840769
49Abnormal respiratory epithelium morphology (HP:0012253)2.56840769
50Inability to walk (HP:0002540)2.56598379
51Bundle branch block (HP:0011710)2.51759517
52Deep palmar crease (HP:0006191)2.51424711
53Anxiety (HP:0000739)2.51281995
54Bile duct proliferation (HP:0001408)2.50898392
55Abnormal biliary tract physiology (HP:0012439)2.50898392
56Ventricular fibrillation (HP:0001663)2.49637646
57Hemiplegia (HP:0002301)2.48731419
58Torticollis (HP:0000473)2.43390891
59Epileptic encephalopathy (HP:0200134)2.43048573
60Action tremor (HP:0002345)2.43016910
61Pendular nystagmus (HP:0012043)2.42102052
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.41732288
63Epileptiform EEG discharges (HP:0011182)2.35934076
64Sclerocornea (HP:0000647)2.35931442
65Hypothermia (HP:0002045)2.35714422
66Urinary urgency (HP:0000012)2.35465835
67Limb dystonia (HP:0002451)2.35395922
68Abnormal rod and cone electroretinograms (HP:0008323)2.34331142
69Gait imbalance (HP:0002141)2.34248099
70Absent speech (HP:0001344)2.34174253
71Cerebral inclusion bodies (HP:0100314)2.33280092
72Progressive inability to walk (HP:0002505)2.32954530
73Tachypnea (HP:0002789)2.32088939
74Pachygyria (HP:0001302)2.31862548
75Abnormal eating behavior (HP:0100738)2.30926322
76Postural instability (HP:0002172)2.29521804
77Hemiparesis (HP:0001269)2.28656335
78Impaired vibration sensation in the lower limbs (HP:0002166)2.26969130
79Focal dystonia (HP:0004373)2.26068366
80Resting tremor (HP:0002322)2.25859655
81Ketosis (HP:0001946)2.25544152
82Spastic gait (HP:0002064)2.25270857
83Abolished electroretinogram (ERG) (HP:0000550)2.24567929
84Anencephaly (HP:0002323)2.24345495
85Insomnia (HP:0100785)2.24292114
86Hypsarrhythmia (HP:0002521)2.23815501
87EEG with generalized epileptiform discharges (HP:0011198)2.23109804
88Abnormality of oral frenula (HP:0000190)2.22414509
89Global brain atrophy (HP:0002283)2.21770062
90Neoplasm of the heart (HP:0100544)2.19088612
91Generalized tonic-clonic seizures (HP:0002069)2.19066537
92Polygenic inheritance (HP:0010982)2.18117417
93Hyperactive renin-angiotensin system (HP:0000841)2.17851053
94Clumsiness (HP:0002312)2.16245638
95Dysmetric saccades (HP:0000641)2.14527495
96Large for gestational age (HP:0001520)2.14165191
97Short 1st metacarpal (HP:0010034)2.13638363
98Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.13638363
99Protruding tongue (HP:0010808)2.13185904
100Hyperkalemia (HP:0002153)2.11890261
101Enlarged penis (HP:0000040)2.11866982
102Impaired smooth pursuit (HP:0007772)2.11400762
103Long toe (HP:0010511)2.11038337
104Craniofacial dystonia (HP:0012179)2.10474396
105Symptomatic seizures (HP:0011145)2.10397578
106Abnormal respiratory motile cilium physiology (HP:0012261)2.10252815
107Abnormality of renin-angiotensin system (HP:0000847)2.10178529
108Hyperacusis (HP:0010780)2.09975336
109Congenital primary aphakia (HP:0007707)2.08868073
110Absence seizures (HP:0002121)2.08098930
111Abnormality of calcium-phosphate metabolism (HP:0100530)2.08084818
112Polyuria (HP:0000103)2.07380179
113Hypoventilation (HP:0002791)2.07216731
114Hypercortisolism (HP:0001578)2.06635796
115Pointed chin (HP:0000307)2.06010673
116Atonic seizures (HP:0010819)2.05586745
117Severe muscular hypotonia (HP:0006829)2.05498086
118Furrowed tongue (HP:0000221)2.05004864
119Neurofibrillary tangles (HP:0002185)2.04775262
120Abnormality of the labia minora (HP:0012880)2.03877577
121Progressive cerebellar ataxia (HP:0002073)2.02980158
122Agitation (HP:0000713)2.01116314
123Hypomagnesemia (HP:0002917)2.00392525
1243-Methylglutaconic aciduria (HP:0003535)1.99856036
125Annular pancreas (HP:0001734)1.99215591
126Pheochromocytoma (HP:0002666)1.98890111
127Nephrogenic diabetes insipidus (HP:0009806)1.97949289
128Turricephaly (HP:0000262)1.97635794
129Concave nail (HP:0001598)1.97267169
130Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97084455
131Abnormality of endocrine pancreas physiology (HP:0012093)1.96916350
132Abnormality of the pancreatic islet cells (HP:0006476)1.96916350
133Congenital hepatic fibrosis (HP:0002612)1.96331973
134Broad-based gait (HP:0002136)1.96099833
135Aplasia/Hypoplasia of the spleen (HP:0010451)1.96014000
136Neuronal loss in central nervous system (HP:0002529)1.95236879
137Dysmetria (HP:0001310)1.94890056
138Abnormal ciliary motility (HP:0012262)1.93842138
139Male pseudohermaphroditism (HP:0000037)1.93816815
140Atrioventricular block (HP:0001678)1.93469195
141Retinal dysplasia (HP:0007973)1.92809595
142Genetic anticipation (HP:0003743)1.91648562
143Dysostosis multiplex (HP:0000943)1.91588862
144Spinal canal stenosis (HP:0003416)1.90966548
145Limb hypertonia (HP:0002509)1.90178806
146Hypoglycemic coma (HP:0001325)1.89960441
147Late onset (HP:0003584)1.88818768
148Congenital sensorineural hearing impairment (HP:0008527)1.87871882
149Stereotypic behavior (HP:0000733)1.87525181
150Retinal atrophy (HP:0001105)1.86942942
151Abnormality of polysaccharide metabolism (HP:0011012)1.86563411
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86563411
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86563411
154Gaze-evoked nystagmus (HP:0000640)1.86409466
155Urinary bladder sphincter dysfunction (HP:0002839)1.86358928
156Amyotrophic lateral sclerosis (HP:0007354)1.86104970
157Abnormality of the 1st metacarpal (HP:0010009)1.84866938
158Tetraplegia (HP:0002445)1.84166768
159Clonus (HP:0002169)1.83234959
160Rhinitis (HP:0012384)1.81954231
161Neuroendocrine neoplasm (HP:0100634)1.81610651
162Chronic bronchitis (HP:0004469)1.81443996
163Bronchomalacia (HP:0002780)1.80594676
164Rib fusion (HP:0000902)1.79876337
165Dialeptic seizures (HP:0011146)1.79335921
166Status epilepticus (HP:0002133)1.79005774
167Aplasia/Hypoplasia of the patella (HP:0006498)1.78727046
168Cerebral aneurysm (HP:0004944)1.78601496
169Severe visual impairment (HP:0001141)1.78367037
170Oligodactyly (hands) (HP:0001180)1.77640417
171Mucopolysacchariduria (HP:0008155)1.77469786
172Asplenia (HP:0001746)1.77447185
173Patellar aplasia (HP:0006443)1.76858234
174Genital tract atresia (HP:0001827)1.74450220
175Drooling (HP:0002307)1.74286899
176Attenuation of retinal blood vessels (HP:0007843)1.73879818
177Polyphagia (HP:0002591)1.73095163
178Disproportionate short-trunk short stature (HP:0003521)1.72533349
179Tented upper lip vermilion (HP:0010804)1.71999790
180Cerebellar dysplasia (HP:0007033)1.71689435
181Narrow forehead (HP:0000341)1.70823807
182Vaginal atresia (HP:0000148)1.69310597
183Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68839727
184Renal cortical cysts (HP:0000803)1.68786115
185Intestinal atresia (HP:0011100)1.67422994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.75661960
2PINK13.79859613
3EPHA43.41153653
4MAP3K93.30688451
5NTRK33.30683531
6TRIB33.14424307
7CAMKK12.85224081
8PRKD32.75788914
9ADRBK22.50892068
10ACVR1B2.43812148
11KSR22.43439298
12PASK2.42263377
13GRK12.35761121
14ERN12.32034844
15DAPK22.23576817
16CASK2.16221143
17TAOK11.90898172
18OXSR11.87007149
19SCYL21.80651689
20STK391.80172468
21MINK11.76766486
22WNK31.76011941
23TLK11.74358768
24PNCK1.70542600
25TYRO31.69734492
26NTRK21.68914439
27PKN21.68591048
28KSR11.68555888
29NTRK11.68437158
30BMPR1B1.64247359
31RIPK11.61470936
32PAK61.59500863
33MAP4K21.56547433
34MAP3K21.55963833
35MAP3K41.48767455
36CAMKK21.40323126
37PRKCH1.38264121
38DYRK21.37683850
39MAP2K71.35763278
40CDK51.34686491
41MARK11.29752575
42STK161.27733759
43RET1.26645675
44SIK21.24946965
45UHMK11.22999864
46WNK41.20791446
47ZAK1.19538983
48AKT31.19301084
49DAPK11.17033179
50EPHA31.15191821
51PRKD21.14562728
52ICK1.13887085
53SIK11.12674033
54MAPKAPK31.11408708
55DMPK1.09262372
56NUAK11.08956031
57ALK1.08551498
58IRAK11.07123240
59FGFR41.06566449
60FES1.05333962
61LMTK21.04561421
62TNIK1.04357134
63MARK21.04278140
64PRKCI1.01190457
65RIPK41.00886888
66PAK30.98792958
67PDGFRA0.96968999
68MAP3K10.96856466
69ARAF0.96822841
70INSRR0.96816929
71MAP2K60.95154400
72STK380.94623297
73ADRBK10.93473485
74PTK20.92860250
75HIPK20.91585239
76PTK2B0.89963379
77PRKCE0.89556298
78RAF10.89549686
79MAP3K130.87482303
80CAMK1G0.86234281
81MAP3K100.84477580
82PDPK10.84015455
83PTK60.82945685
84STK38L0.81803096
85NME10.77079853
86PDK10.75923354
87MAP2K40.74249780
88PRKCG0.72715498
89SGK30.69218382
90CDC42BPA0.68888698
91SGK20.68837984
92CSNK1G20.68562425
93BMX0.67885341
94RPS6KA20.67200717
95MAP3K70.67171009
96PIK3CA0.66681344
97BRSK20.66073717
98STK110.65569376
99PHKG20.64925914
100PHKG10.64925914
101MAP2K20.64869934
102CHUK0.64762245
103EEF2K0.64226350
104PRKAA10.62574474
105CAMK1D0.62512399
106TNK20.62080503
107MAP2K10.58267436
108IKBKB0.57309955
109FYN0.56674478
110CAMK2B0.56367621
111MAPK150.56331410
112CDK150.56258085
113CDK180.55647600
114TRIM280.54246631
115SGK4940.54072936
116SGK2230.54072936
117MAPKAPK50.53772699
118PRKCZ0.53141932
119BCKDK0.53040462
120WNK10.52536070
121CDK140.51858878
122CAMK10.51581607
123TAOK30.51227413
124PRKAA20.49307771
125PDGFRB0.49211657
126JAK10.47609562
127PRKACA0.47221419
128CDK11A0.47147115
129SGK10.46588293
130JAK20.45912239
131CAMK40.45339700
132RPS6KA60.45281344
133EPHA20.44937132
134CSNK1A10.44923902
135MAPK130.44659543
136NLK0.43688461
137FGFR20.43669234
138BRSK10.42975960
139PKN10.42510703
140MAPK100.41393886
141PRKD10.40131804
142GRK60.39233346
143FER0.38496135
144CAMK2A0.38410358
145MAP3K120.38251565
146RPS6KA30.38248849
147SIK30.37439652
148NEK10.36988435
149LATS20.36211002
150FGFR30.35968642
151MARK30.35756052
152FGFR10.35578227
153MAPK80.34134498
154PRKG10.33980452
155FLT30.33634814
156DYRK1A0.33481494
157CAMK2D0.33075574
158PRKCQ0.32899278

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.86746757
2Phototransduction_Homo sapiens_hsa047442.64303252
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.55700189
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.49163416
5Insulin secretion_Homo sapiens_hsa049112.44803573
6Synaptic vesicle cycle_Homo sapiens_hsa047212.35609463
7Circadian entrainment_Homo sapiens_hsa047132.30607794
8Nitrogen metabolism_Homo sapiens_hsa009102.23963647
9GABAergic synapse_Homo sapiens_hsa047272.21166337
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.19124589
11Olfactory transduction_Homo sapiens_hsa047402.16342298
12Long-term potentiation_Homo sapiens_hsa047202.16207918
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.15198390
14Amphetamine addiction_Homo sapiens_hsa050312.00022842
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94669194
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.94550055
17Glutamatergic synapse_Homo sapiens_hsa047241.93457860
18Morphine addiction_Homo sapiens_hsa050321.88584083
19Dopaminergic synapse_Homo sapiens_hsa047281.86608920
20Nicotine addiction_Homo sapiens_hsa050331.85917032
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84276637
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83741346
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83604917
24Cocaine addiction_Homo sapiens_hsa050301.82848873
25Selenocompound metabolism_Homo sapiens_hsa004501.82671704
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82553370
27Linoleic acid metabolism_Homo sapiens_hsa005911.81689225
28Type II diabetes mellitus_Homo sapiens_hsa049301.78317630
29Tryptophan metabolism_Homo sapiens_hsa003801.75870556
30Gastric acid secretion_Homo sapiens_hsa049711.74440388
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74270669
32Cholinergic synapse_Homo sapiens_hsa047251.69003292
33Salivary secretion_Homo sapiens_hsa049701.65964407
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64069872
35Oxidative phosphorylation_Homo sapiens_hsa001901.54288808
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53890876
37Ether lipid metabolism_Homo sapiens_hsa005651.52808350
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50187817
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.49312921
40Protein export_Homo sapiens_hsa030601.48787729
41Pancreatic secretion_Homo sapiens_hsa049721.37839706
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37750964
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36054353
44Regulation of autophagy_Homo sapiens_hsa041401.34171938
45Renin secretion_Homo sapiens_hsa049241.31104943
46Oxytocin signaling pathway_Homo sapiens_hsa049211.28280726
47GnRH signaling pathway_Homo sapiens_hsa049121.20005787
48Vitamin B6 metabolism_Homo sapiens_hsa007501.18598644
49Cardiac muscle contraction_Homo sapiens_hsa042601.18351966
50Estrogen signaling pathway_Homo sapiens_hsa049151.14928509
51ABC transporters_Homo sapiens_hsa020101.14834586
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12887365
53Taste transduction_Homo sapiens_hsa047421.10617601
54cAMP signaling pathway_Homo sapiens_hsa040241.10301873
55Bile secretion_Homo sapiens_hsa049761.05227622
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04747154
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04468781
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04194476
59Calcium signaling pathway_Homo sapiens_hsa040201.03636385
60Gap junction_Homo sapiens_hsa045401.03357396
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01940257
62Thyroid hormone synthesis_Homo sapiens_hsa049181.01906158
63Glioma_Homo sapiens_hsa052141.00941831
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99884172
65Long-term depression_Homo sapiens_hsa047300.99554840
66Glucagon signaling pathway_Homo sapiens_hsa049220.99318239
67Dorso-ventral axis formation_Homo sapiens_hsa043200.99042916
68Vibrio cholerae infection_Homo sapiens_hsa051100.98630477
69Parkinsons disease_Homo sapiens_hsa050120.98429252
70Ovarian steroidogenesis_Homo sapiens_hsa049130.94465687
71Basal transcription factors_Homo sapiens_hsa030220.93980956
72Fatty acid biosynthesis_Homo sapiens_hsa000610.93921824
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.93921513
74VEGF signaling pathway_Homo sapiens_hsa043700.93485891
75Peroxisome_Homo sapiens_hsa041460.89822800
76Fanconi anemia pathway_Homo sapiens_hsa034600.88954550
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88900429
78Caffeine metabolism_Homo sapiens_hsa002320.86542927
79Melanogenesis_Homo sapiens_hsa049160.86111392
80Homologous recombination_Homo sapiens_hsa034400.85606702
81Serotonergic synapse_Homo sapiens_hsa047260.85524194
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.85239351
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82825754
84Mineral absorption_Homo sapiens_hsa049780.82688108
85Insulin signaling pathway_Homo sapiens_hsa049100.82280140
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81370270
87beta-Alanine metabolism_Homo sapiens_hsa004100.81009347
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80733440
89Huntingtons disease_Homo sapiens_hsa050160.80281672
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79518194
91Collecting duct acid secretion_Homo sapiens_hsa049660.79281256
92Glycerolipid metabolism_Homo sapiens_hsa005610.79107938
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.74731406
94ErbB signaling pathway_Homo sapiens_hsa040120.74620380
95Butanoate metabolism_Homo sapiens_hsa006500.73831155
96Histidine metabolism_Homo sapiens_hsa003400.73447040
97Non-small cell lung cancer_Homo sapiens_hsa052230.72769896
98mTOR signaling pathway_Homo sapiens_hsa041500.72715925
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.71648686
100Insulin resistance_Homo sapiens_hsa049310.70917836
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69337342
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69094358
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67638889
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65941318
105Endometrial cancer_Homo sapiens_hsa052130.65938339
106Chemical carcinogenesis_Homo sapiens_hsa052040.65699249
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65540261
108Circadian rhythm_Homo sapiens_hsa047100.64013171
109Arginine biosynthesis_Homo sapiens_hsa002200.63847286
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63674393
111Prion diseases_Homo sapiens_hsa050200.62877038
112Vitamin digestion and absorption_Homo sapiens_hsa049770.61975784
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61078156
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61049386
115Alzheimers disease_Homo sapiens_hsa050100.60655090
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58533753
117Renal cell carcinoma_Homo sapiens_hsa052110.57990030
118Propanoate metabolism_Homo sapiens_hsa006400.57777836
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.57734049
120Type I diabetes mellitus_Homo sapiens_hsa049400.57488307
121Dilated cardiomyopathy_Homo sapiens_hsa054140.55245748
122Endocytosis_Homo sapiens_hsa041440.55107238
123Inositol phosphate metabolism_Homo sapiens_hsa005620.54474899
124Sphingolipid metabolism_Homo sapiens_hsa006000.53477035
125Sulfur metabolism_Homo sapiens_hsa009200.52329296
126RNA degradation_Homo sapiens_hsa030180.52183314
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50961868
128Arachidonic acid metabolism_Homo sapiens_hsa005900.49112793
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.48432934
130Hedgehog signaling pathway_Homo sapiens_hsa043400.47904193
131Prolactin signaling pathway_Homo sapiens_hsa049170.47695776
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.47144708
133Oocyte meiosis_Homo sapiens_hsa041140.45687295
134Lysosome_Homo sapiens_hsa041420.45296098
135RNA polymerase_Homo sapiens_hsa030200.44787634
136Choline metabolism in cancer_Homo sapiens_hsa052310.44772794
137Rap1 signaling pathway_Homo sapiens_hsa040150.44188715
138Metabolic pathways_Homo sapiens_hsa011000.42075382
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41993447
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.40873702
141MAPK signaling pathway_Homo sapiens_hsa040100.40751888
142Steroid biosynthesis_Homo sapiens_hsa001000.40534660
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39913502
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39542844
145Axon guidance_Homo sapiens_hsa043600.39483606
146Fat digestion and absorption_Homo sapiens_hsa049750.39185974
147AMPK signaling pathway_Homo sapiens_hsa041520.38469513
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37275093
149T cell receptor signaling pathway_Homo sapiens_hsa046600.36837485
150Chemokine signaling pathway_Homo sapiens_hsa040620.36807332
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36682031
152Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36475219
153N-Glycan biosynthesis_Homo sapiens_hsa005100.36405875
154Folate biosynthesis_Homo sapiens_hsa007900.35847969
155Primary bile acid biosynthesis_Homo sapiens_hsa001200.34880606
156Steroid hormone biosynthesis_Homo sapiens_hsa001400.34816320
157Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33389696
158Retinol metabolism_Homo sapiens_hsa008300.32017662

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