

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.31874013 |
| 2 | synaptic vesicle maturation (GO:0016188) | 6.28610974 |
| 3 | locomotory exploration behavior (GO:0035641) | 5.92371314 |
| 4 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.89536162 |
| 5 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.49495547 |
| 6 | synaptic vesicle exocytosis (GO:0016079) | 5.30716815 |
| 7 | glutamate secretion (GO:0014047) | 5.20840947 |
| 8 | vocalization behavior (GO:0071625) | 5.17389646 |
| 9 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.12245466 |
| 10 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.06770027 |
| 11 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.87782133 |
| 12 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.69425649 |
| 13 | neuronal action potential propagation (GO:0019227) | 4.55951507 |
| 14 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.55746056 |
| 15 | regulation of synaptic vesicle transport (GO:1902803) | 4.55160484 |
| 16 | protein localization to synapse (GO:0035418) | 4.54230421 |
| 17 | neurotransmitter secretion (GO:0007269) | 4.54069285 |
| 18 | L-amino acid import (GO:0043092) | 4.51240411 |
| 19 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.50298717 |
| 20 | cerebellar granule cell differentiation (GO:0021707) | 4.50167525 |
| 21 | exploration behavior (GO:0035640) | 4.43041256 |
| 22 | layer formation in cerebral cortex (GO:0021819) | 4.37117908 |
| 23 | neuron cell-cell adhesion (GO:0007158) | 4.34021996 |
| 24 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.29686092 |
| 25 | regulation of synapse structural plasticity (GO:0051823) | 4.22003495 |
| 26 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.21745020 |
| 27 | synaptic transmission, glutamatergic (GO:0035249) | 4.18441018 |
| 28 | central nervous system myelination (GO:0022010) | 4.07504223 |
| 29 | axon ensheathment in central nervous system (GO:0032291) | 4.07504223 |
| 30 | dendritic spine morphogenesis (GO:0060997) | 4.02465247 |
| 31 | gamma-aminobutyric acid transport (GO:0015812) | 3.98123936 |
| 32 | potassium ion homeostasis (GO:0055075) | 3.97748088 |
| 33 | glutamate receptor signaling pathway (GO:0007215) | 3.92953641 |
| 34 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.89024169 |
| 35 | amino acid import (GO:0043090) | 3.88990474 |
| 36 | cellular potassium ion homeostasis (GO:0030007) | 3.86309807 |
| 37 | potassium ion import (GO:0010107) | 3.82532941 |
| 38 | neuron-neuron synaptic transmission (GO:0007270) | 3.81180908 |
| 39 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.80386006 |
| 40 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.78094948 |
| 41 | regulation of synapse maturation (GO:0090128) | 3.76343219 |
| 42 | positive regulation of membrane potential (GO:0045838) | 3.75428568 |
| 43 | long-term memory (GO:0007616) | 3.74734749 |
| 44 | activation of protein kinase A activity (GO:0034199) | 3.73431892 |
| 45 | proline transport (GO:0015824) | 3.71344495 |
| 46 | sodium ion export (GO:0071436) | 3.70514190 |
| 47 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.68972501 |
| 48 | neurotransmitter transport (GO:0006836) | 3.64630768 |
| 49 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.64114459 |
| 50 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.61982790 |
| 51 | neuromuscular process controlling balance (GO:0050885) | 3.56647626 |
| 52 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.56028858 |
| 53 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.55252162 |
| 54 | synaptic vesicle endocytosis (GO:0048488) | 3.50532888 |
| 55 | regulation of synaptic plasticity (GO:0048167) | 3.50014064 |
| 56 | regulation of postsynaptic membrane potential (GO:0060078) | 3.49320819 |
| 57 | regulation of neurotransmitter secretion (GO:0046928) | 3.47900640 |
| 58 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.45963815 |
| 59 | neuromuscular synaptic transmission (GO:0007274) | 3.44901909 |
| 60 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.44685378 |
| 61 | transmission of nerve impulse (GO:0019226) | 3.44402350 |
| 62 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.44363330 |
| 63 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.41553936 |
| 64 | neuromuscular process controlling posture (GO:0050884) | 3.41413525 |
| 65 | regulation of neurotransmitter levels (GO:0001505) | 3.38802526 |
| 66 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.38737306 |
| 67 | neuron recognition (GO:0008038) | 3.36801664 |
| 68 | glycine transport (GO:0015816) | 3.36393229 |
| 69 | dendrite morphogenesis (GO:0048813) | 3.32238514 |
| 70 | cell communication by electrical coupling (GO:0010644) | 3.31515116 |
| 71 | positive regulation of synapse maturation (GO:0090129) | 3.28460528 |
| 72 | cell differentiation in hindbrain (GO:0021533) | 3.26530448 |
| 73 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.26405322 |
| 74 | auditory behavior (GO:0031223) | 3.26127976 |
| 75 | cellular sodium ion homeostasis (GO:0006883) | 3.24387201 |
| 76 | neuronal ion channel clustering (GO:0045161) | 3.24006428 |
| 77 | acidic amino acid transport (GO:0015800) | 3.23029387 |
| 78 | membrane depolarization during action potential (GO:0086010) | 3.22686789 |
| 79 | regulation of neurotransmitter transport (GO:0051588) | 3.22233659 |
| 80 | prepulse inhibition (GO:0060134) | 3.22057641 |
| 81 | regulation of vesicle fusion (GO:0031338) | 3.20771713 |
| 82 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.20365111 |
| 83 | presynaptic membrane organization (GO:0097090) | 3.20111529 |
| 84 | neurotransmitter uptake (GO:0001504) | 3.19972263 |
| 85 | axonal fasciculation (GO:0007413) | 3.16706871 |
| 86 | chemosensory behavior (GO:0007635) | 3.15921624 |
| 87 | long-term synaptic potentiation (GO:0060291) | 3.15205839 |
| 88 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.14783223 |
| 89 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.12172841 |
| 90 | positive regulation of neurotransmitter transport (GO:0051590) | 3.11179607 |
| 91 | membrane depolarization (GO:0051899) | 3.11118132 |
| 92 | regulation of ARF protein signal transduction (GO:0032012) | 3.11087891 |
| 93 | synaptic vesicle transport (GO:0048489) | 3.10138031 |
| 94 | establishment of synaptic vesicle localization (GO:0097480) | 3.10138031 |
| 95 | response to auditory stimulus (GO:0010996) | 3.08815255 |
| 96 | cerebellar Purkinje cell layer development (GO:0021680) | 3.08723870 |
| 97 | positive regulation of dendritic spine development (GO:0060999) | 3.07769598 |
| 98 | innervation (GO:0060384) | 3.07742569 |
| 99 | mating behavior (GO:0007617) | 3.07596457 |
| 100 | membrane hyperpolarization (GO:0060081) | 3.06551675 |
| 101 | regulation of exocytosis (GO:0017157) | 3.06016714 |
| 102 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.05295718 |
| 103 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.05283275 |
| 104 | vesicle transport along microtubule (GO:0047496) | 3.05137271 |
| 105 | presynaptic membrane assembly (GO:0097105) | 3.04705479 |
| 106 | cell migration in hindbrain (GO:0021535) | 3.03594768 |
| 107 | postsynaptic membrane organization (GO:0001941) | 3.02990436 |
| 108 | dendritic spine organization (GO:0097061) | 3.01937956 |
| 109 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.00302141 |
| 110 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.99721709 |
| 111 | signal release (GO:0023061) | 2.98459303 |
| 112 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.98324649 |
| 113 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.95630067 |
| 114 | regulation of synaptic transmission (GO:0050804) | 2.94389909 |
| 115 | intraspecies interaction between organisms (GO:0051703) | 2.93037011 |
| 116 | social behavior (GO:0035176) | 2.93037011 |
| 117 | neuromuscular process (GO:0050905) | 2.91827859 |
| 118 | learning (GO:0007612) | 2.89435953 |
| 119 | response to pheromone (GO:0019236) | 2.89307504 |
| 120 | positive regulation of synaptic transmission (GO:0050806) | 2.88842724 |
| 121 | synaptic transmission (GO:0007268) | 2.88724623 |
| 122 | synapse assembly (GO:0007416) | 2.88460894 |
| 123 | regulation of dendritic spine development (GO:0060998) | 2.87741331 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.04090744 |
| 2 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.08103087 |
| 3 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.01400893 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.00305863 |
| 5 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.96173081 |
| 6 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.90260347 |
| 7 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.88706160 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.77309703 |
| 9 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.77309703 |
| 10 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.73056684 |
| 11 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.71821578 |
| 12 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.64335597 |
| 13 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.60180561 |
| 14 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.50430263 |
| 15 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.48832212 |
| 16 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.47426649 |
| 17 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.46679731 |
| 18 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.46115206 |
| 19 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.42073586 |
| 20 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.40739054 |
| 21 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.34199525 |
| 22 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.27106769 |
| 23 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.25088862 |
| 24 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.24401200 |
| 25 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.20135987 |
| 26 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.19779915 |
| 27 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.15924610 |
| 28 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.82650567 |
| 29 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.72905409 |
| 30 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.51751251 |
| 31 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.51120205 |
| 32 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.46871481 |
| 33 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.40955818 |
| 34 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.40914063 |
| 35 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.40603554 |
| 36 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.39793407 |
| 37 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.39367474 |
| 38 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.38197032 |
| 39 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.37399484 |
| 40 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.30841894 |
| 41 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.29008760 |
| 42 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.27710082 |
| 43 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.27206170 |
| 44 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.22624116 |
| 45 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.22233544 |
| 46 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.21018489 |
| 47 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.20736324 |
| 48 | AR_19668381_ChIP-Seq_PC3_Human | 1.19540981 |
| 49 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.18849213 |
| 50 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.16958333 |
| 51 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.16476572 |
| 52 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.15307974 |
| 53 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.14216213 |
| 54 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.13683920 |
| 55 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.11629700 |
| 56 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.10786583 |
| 57 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.10392434 |
| 58 | STAT3_23295773_ChIP-Seq_U87_Human | 1.08523759 |
| 59 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.08415575 |
| 60 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06283600 |
| 61 | * GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.06249399 |
| 62 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.04302113 |
| 63 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.04039301 |
| 64 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.03566061 |
| 65 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.02551925 |
| 66 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.02495544 |
| 67 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.01758394 |
| 68 | AR_25329375_ChIP-Seq_VCAP_Human | 1.00079095 |
| 69 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.99831726 |
| 70 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.99326360 |
| 71 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.98601913 |
| 72 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.98497238 |
| 73 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.98210435 |
| 74 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.97838337 |
| 75 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.97068235 |
| 76 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.96584876 |
| 77 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.96484673 |
| 78 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.96057447 |
| 79 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.95937753 |
| 80 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.94897949 |
| 81 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.94558248 |
| 82 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.93809627 |
| 83 | P300_19829295_ChIP-Seq_ESCs_Human | 0.93766228 |
| 84 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.93196626 |
| 85 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.92807288 |
| 86 | TCF4_23295773_ChIP-Seq_U87_Human | 0.91570274 |
| 87 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.91530322 |
| 88 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.91259709 |
| 89 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.90767082 |
| 90 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.89063393 |
| 91 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.88901258 |
| 92 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.87710531 |
| 93 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.87457154 |
| 94 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.87360581 |
| 95 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.86972646 |
| 96 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.85624161 |
| 97 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.85501629 |
| 98 | P68_20966046_ChIP-Seq_HELA_Human | 0.85493656 |
| 99 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.84978057 |
| 100 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.84295054 |
| 101 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.83969577 |
| 102 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.82701990 |
| 103 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.82210415 |
| 104 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.81128249 |
| 105 | SMAD4_21741376_ChIP-Seq_ESCs_Human | 0.80907262 |
| 106 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.79792051 |
| 107 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.79119994 |
| 108 | * RUNX2_22187159_ChIP-Seq_PCA_Human | 0.78968344 |
| 109 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.78605471 |
| 110 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.77926789 |
| 111 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.77867124 |
| 112 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.77397434 |
| 113 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.77325473 |
| 114 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.76619315 |
| 115 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.76403107 |
| 116 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.76403107 |
| 117 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.76374991 |
| 118 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.76147862 |
| 119 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.74418988 |
| 120 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.74401720 |
| 121 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.73817758 |
| 122 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 0.69427906 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.58528073 |
| 2 | MP0003880_abnormal_central_pattern | 4.22502842 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.11020166 |
| 4 | MP0004270_analgesia | 3.90975874 |
| 5 | MP0009745_abnormal_behavioral_response | 3.27671533 |
| 6 | MP0002063_abnormal_learning/memory/cond | 3.23600890 |
| 7 | MP0002064_seizures | 3.08139643 |
| 8 | MP0005423_abnormal_somatic_nervous | 3.01024236 |
| 9 | MP0009046_muscle_twitch | 2.94526990 |
| 10 | MP0001968_abnormal_touch/_nociception | 2.86138472 |
| 11 | MP0002822_catalepsy | 2.84820145 |
| 12 | MP0002734_abnormal_mechanical_nocicepti | 2.70737072 |
| 13 | MP0002572_abnormal_emotion/affect_behav | 2.67771078 |
| 14 | MP0002272_abnormal_nervous_system | 2.63133213 |
| 15 | MP0001486_abnormal_startle_reflex | 2.46485319 |
| 16 | MP0002909_abnormal_adrenal_gland | 2.32948385 |
| 17 | MP0002736_abnormal_nociception_after | 2.17940471 |
| 18 | MP0002735_abnormal_chemical_nociception | 2.17381116 |
| 19 | MP0001501_abnormal_sleep_pattern | 2.16550482 |
| 20 | MP0002733_abnormal_thermal_nociception | 2.12833080 |
| 21 | MP0009780_abnormal_chondrocyte_physiolo | 2.08014263 |
| 22 | MP0004858_abnormal_nervous_system | 2.04889505 |
| 23 | MP0001440_abnormal_grooming_behavior | 2.02744779 |
| 24 | MP0001970_abnormal_pain_threshold | 1.99805595 |
| 25 | MP0003329_amyloid_beta_deposits | 1.99470385 |
| 26 | MP0008569_lethality_at_weaning | 1.98896036 |
| 27 | MP0002067_abnormal_sensory_capabilities | 1.90859076 |
| 28 | MP0001984_abnormal_olfaction | 1.90413923 |
| 29 | MP0002184_abnormal_innervation | 1.87522581 |
| 30 | MP0004811_abnormal_neuron_physiology | 1.84971349 |
| 31 | MP0004885_abnormal_endolymph | 1.82601308 |
| 32 | MP0002557_abnormal_social/conspecific_i | 1.78079771 |
| 33 | MP0001986_abnormal_taste_sensitivity | 1.76835791 |
| 34 | MP0000955_abnormal_spinal_cord | 1.74312081 |
| 35 | MP0000778_abnormal_nervous_system | 1.70065666 |
| 36 | MP0005386_behavior/neurological_phenoty | 1.60429852 |
| 37 | MP0004924_abnormal_behavior | 1.60429852 |
| 38 | MP0005646_abnormal_pituitary_gland | 1.57687659 |
| 39 | MP0006276_abnormal_autonomic_nervous | 1.56110189 |
| 40 | MP0003123_paternal_imprinting | 1.56095156 |
| 41 | MP0005645_abnormal_hypothalamus_physiol | 1.52534199 |
| 42 | MP0002882_abnormal_neuron_morphology | 1.49894276 |
| 43 | MP0003879_abnormal_hair_cell | 1.49342563 |
| 44 | MP0003283_abnormal_digestive_organ | 1.47343696 |
| 45 | MP0002066_abnormal_motor_capabilities/c | 1.44428318 |
| 46 | MP0003633_abnormal_nervous_system | 1.36519680 |
| 47 | MP0003787_abnormal_imprinting | 1.35176672 |
| 48 | MP0001502_abnormal_circadian_rhythm | 1.32821740 |
| 49 | MP0004147_increased_porphyrin_level | 1.31019759 |
| 50 | MP0004142_abnormal_muscle_tone | 1.20894644 |
| 51 | MP0003631_nervous_system_phenotype | 1.15111041 |
| 52 | MP0000013_abnormal_adipose_tissue | 1.13941404 |
| 53 | MP0002152_abnormal_brain_morphology | 1.13425224 |
| 54 | MP0003122_maternal_imprinting | 1.12354623 |
| 55 | MP0002229_neurodegeneration | 1.11318534 |
| 56 | MP0008961_abnormal_basal_metabolism | 1.10440087 |
| 57 | MP0004145_abnormal_muscle_electrophysio | 1.07150426 |
| 58 | MP0001905_abnormal_dopamine_level | 1.04863449 |
| 59 | MP0001529_abnormal_vocalization | 1.03805003 |
| 60 | MP0008877_abnormal_DNA_methylation | 1.02353062 |
| 61 | MP0002069_abnormal_eating/drinking_beha | 1.01317386 |
| 62 | MP0003634_abnormal_glial_cell | 0.97471936 |
| 63 | MP0004742_abnormal_vestibular_system | 0.96612236 |
| 64 | MP0004043_abnormal_pH_regulation | 0.96068147 |
| 65 | MP0005551_abnormal_eye_electrophysiolog | 0.93969812 |
| 66 | MP0008872_abnormal_physiological_respon | 0.92465435 |
| 67 | MP0005499_abnormal_olfactory_system | 0.91355351 |
| 68 | MP0005394_taste/olfaction_phenotype | 0.91355351 |
| 69 | MP0003075_altered_response_to | 0.91127513 |
| 70 | MP0003690_abnormal_glial_cell | 0.90666845 |
| 71 | MP0000920_abnormal_myelination | 0.90197137 |
| 72 | MP0010386_abnormal_urinary_bladder | 0.89849779 |
| 73 | MP0003632_abnormal_nervous_system | 0.89279733 |
| 74 | MP0005535_abnormal_body_temperature | 0.85659847 |
| 75 | MP0000604_amyloidosis | 0.84516784 |
| 76 | MP0003121_genomic_imprinting | 0.82987033 |
| 77 | MP0008874_decreased_physiological_sensi | 0.81355633 |
| 78 | MP0000631_abnormal_neuroendocrine_gland | 0.81321507 |
| 79 | MP0002752_abnormal_somatic_nervous | 0.80765118 |
| 80 | MP0001177_atelectasis | 0.80334350 |
| 81 | MP0004085_abnormal_heartbeat | 0.79297255 |
| 82 | MP0002638_abnormal_pupillary_reflex | 0.78923371 |
| 83 | MP0001485_abnormal_pinna_reflex | 0.77960211 |
| 84 | MP0001963_abnormal_hearing_physiology | 0.76308636 |
| 85 | MP0000569_abnormal_digit_pigmentation | 0.75991955 |
| 86 | MP0005167_abnormal_blood-brain_barrier | 0.75588100 |
| 87 | MP0000751_myopathy | 0.75332911 |
| 88 | MP0001299_abnormal_eye_distance/ | 0.72789400 |
| 89 | MP0001348_abnormal_lacrimal_gland | 0.72647698 |
| 90 | MP0006072_abnormal_retinal_apoptosis | 0.72156923 |
| 91 | MP0002653_abnormal_ependyma_morphology | 0.71118823 |
| 92 | MP0003183_abnormal_peptide_metabolism | 0.68932973 |
| 93 | MP0004130_abnormal_muscle_cell | 0.68166739 |
| 94 | MP0002090_abnormal_vision | 0.68031254 |
| 95 | MP0003172_abnormal_lysosome_physiology | 0.67264177 |
| 96 | MP0001188_hyperpigmentation | 0.66490227 |
| 97 | MP0003137_abnormal_impulse_conducting | 0.63801672 |
| 98 | MP0002837_dystrophic_cardiac_calcinosis | 0.60067685 |
| 99 | MP0001664_abnormal_digestion | 0.58324337 |
| 100 | MP0003861_abnormal_nervous_system | 0.57598706 |
| 101 | MP0005187_abnormal_penis_morphology | 0.56348727 |
| 102 | MP0001346_abnormal_lacrimal_gland | 0.55330327 |
| 103 | MP0001943_abnormal_respiration | 0.55210788 |
| 104 | MP0010769_abnormal_survival | 0.54342301 |
| 105 | MP0000026_abnormal_inner_ear | 0.53700965 |
| 106 | MP0004233_abnormal_muscle_weight | 0.53382187 |
| 107 | MP0004510_myositis | 0.53160558 |
| 108 | MP0005623_abnormal_meninges_morphology | 0.52979559 |
| 109 | MP0002234_abnormal_pharynx_morphology | 0.52436569 |
| 110 | MP0002876_abnormal_thyroid_physiology | 0.51348974 |
| 111 | MP0010768_mortality/aging | 0.49963634 |
| 112 | MP0002082_postnatal_lethality | 0.48962531 |
| 113 | MP0010770_preweaning_lethality | 0.48962531 |
| 114 | MP0003956_abnormal_body_size | 0.48554973 |
| 115 | MP0001765_abnormal_ion_homeostasis | 0.46829567 |
| 116 | MP0000639_abnormal_adrenal_gland | 0.43303126 |
| 117 | MP0002873_normal_phenotype | 0.41955189 |
| 118 | MP0005377_hearing/vestibular/ear_phenot | 0.41766576 |
| 119 | MP0003878_abnormal_ear_physiology | 0.41766576 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 7.15550745 |
| 2 | Focal motor seizures (HP:0011153) | 6.66909115 |
| 3 | Visual hallucinations (HP:0002367) | 5.43955084 |
| 4 | Focal seizures (HP:0007359) | 5.31451047 |
| 5 | Action tremor (HP:0002345) | 4.37729274 |
| 6 | Atonic seizures (HP:0010819) | 4.35087877 |
| 7 | Progressive cerebellar ataxia (HP:0002073) | 4.21982061 |
| 8 | Epileptic encephalopathy (HP:0200134) | 4.16413153 |
| 9 | Supranuclear gaze palsy (HP:0000605) | 3.98716195 |
| 10 | Febrile seizures (HP:0002373) | 3.95215653 |
| 11 | Absence seizures (HP:0002121) | 3.80739529 |
| 12 | Ankle clonus (HP:0011448) | 3.60480470 |
| 13 | Generalized tonic-clonic seizures (HP:0002069) | 3.58880538 |
| 14 | Dialeptic seizures (HP:0011146) | 3.44097347 |
| 15 | Depression (HP:0000716) | 3.43246105 |
| 16 | Cerebral hypomyelination (HP:0006808) | 3.28852205 |
| 17 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.28094244 |
| 18 | Dysdiadochokinesis (HP:0002075) | 3.16915569 |
| 19 | Poor eye contact (HP:0000817) | 3.16545453 |
| 20 | Gaze-evoked nystagmus (HP:0000640) | 3.14677386 |
| 21 | Akinesia (HP:0002304) | 3.14282979 |
| 22 | Dysmetria (HP:0001310) | 3.12891148 |
| 23 | Papilledema (HP:0001085) | 3.08952621 |
| 24 | Anxiety (HP:0000739) | 3.08106900 |
| 25 | Broad-based gait (HP:0002136) | 3.04532606 |
| 26 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.99825986 |
| 27 | Postural instability (HP:0002172) | 2.98791232 |
| 28 | Truncal ataxia (HP:0002078) | 2.93364917 |
| 29 | Amblyopia (HP:0000646) | 2.91581659 |
| 30 | Abnormality of the lower motor neuron (HP:0002366) | 2.91531020 |
| 31 | Abnormal social behavior (HP:0012433) | 2.89749671 |
| 32 | Impaired social interactions (HP:0000735) | 2.89749671 |
| 33 | Neurofibrillary tangles (HP:0002185) | 2.85835448 |
| 34 | Abnormal eating behavior (HP:0100738) | 2.82773016 |
| 35 | Impaired smooth pursuit (HP:0007772) | 2.77228408 |
| 36 | Intention tremor (HP:0002080) | 2.76764513 |
| 37 | Genetic anticipation (HP:0003743) | 2.76135515 |
| 38 | Spastic gait (HP:0002064) | 2.75697116 |
| 39 | Ventricular fibrillation (HP:0001663) | 2.73506025 |
| 40 | Mutism (HP:0002300) | 2.71714987 |
| 41 | Cerebral inclusion bodies (HP:0100314) | 2.71193954 |
| 42 | Hemiparesis (HP:0001269) | 2.70219475 |
| 43 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.64283843 |
| 44 | Urinary urgency (HP:0000012) | 2.63579355 |
| 45 | Polyphagia (HP:0002591) | 2.63541531 |
| 46 | Megalencephaly (HP:0001355) | 2.63307141 |
| 47 | Pheochromocytoma (HP:0002666) | 2.62928049 |
| 48 | Torticollis (HP:0000473) | 2.61923812 |
| 49 | Agitation (HP:0000713) | 2.59060323 |
| 50 | Sleep apnea (HP:0010535) | 2.58550695 |
| 51 | Insomnia (HP:0100785) | 2.55105179 |
| 52 | Hemiplegia (HP:0002301) | 2.53212426 |
| 53 | Peripheral hypomyelination (HP:0007182) | 2.52997881 |
| 54 | Scanning speech (HP:0002168) | 2.46489702 |
| 55 | Focal dystonia (HP:0004373) | 2.43402535 |
| 56 | Annular pancreas (HP:0001734) | 2.42708226 |
| 57 | Bradykinesia (HP:0002067) | 2.41005781 |
| 58 | Epileptiform EEG discharges (HP:0011182) | 2.40434401 |
| 59 | EEG with generalized epileptiform discharges (HP:0011198) | 2.39426715 |
| 60 | Abnormality of binocular vision (HP:0011514) | 2.38493453 |
| 61 | Diplopia (HP:0000651) | 2.38493453 |
| 62 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.37647694 |
| 63 | Insidious onset (HP:0003587) | 2.35936637 |
| 64 | Termporal pattern (HP:0011008) | 2.35936637 |
| 65 | Increased circulating renin level (HP:0000848) | 2.35488733 |
| 66 | Abnormality of the corticospinal tract (HP:0002492) | 2.35264226 |
| 67 | Limb dystonia (HP:0002451) | 2.34913313 |
| 68 | Hypsarrhythmia (HP:0002521) | 2.34062484 |
| 69 | Hyperventilation (HP:0002883) | 2.33120045 |
| 70 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.31682334 |
| 71 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.31587353 |
| 72 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.31587353 |
| 73 | Drooling (HP:0002307) | 2.27389908 |
| 74 | Excessive salivation (HP:0003781) | 2.27389908 |
| 75 | Progressive inability to walk (HP:0002505) | 2.25741289 |
| 76 | Stereotypic behavior (HP:0000733) | 2.25598382 |
| 77 | Spastic tetraparesis (HP:0001285) | 2.24296009 |
| 78 | Bundle branch block (HP:0011710) | 2.23479795 |
| 79 | Neuroendocrine neoplasm (HP:0100634) | 2.22389066 |
| 80 | Lower limb muscle weakness (HP:0007340) | 2.20834431 |
| 81 | Dysmetric saccades (HP:0000641) | 2.19324206 |
| 82 | Impaired vibratory sensation (HP:0002495) | 2.18650904 |
| 83 | Craniofacial dystonia (HP:0012179) | 2.14930224 |
| 84 | Choreoathetosis (HP:0001266) | 2.14734651 |
| 85 | Status epilepticus (HP:0002133) | 2.12716482 |
| 86 | Pointed chin (HP:0000307) | 2.10672912 |
| 87 | CNS hypomyelination (HP:0003429) | 2.09047252 |
| 88 | Clonus (HP:0002169) | 2.07821201 |
| 89 | Neuronal loss in central nervous system (HP:0002529) | 2.04534817 |
| 90 | Diminished motivation (HP:0000745) | 2.03092183 |
| 91 | Gait ataxia (HP:0002066) | 1.97092684 |
| 92 | Failure to thrive in infancy (HP:0001531) | 1.95356181 |
| 93 | Hypercortisolism (HP:0001578) | 1.95058067 |
| 94 | Obstructive sleep apnea (HP:0002870) | 1.94655767 |
| 95 | Fetal akinesia sequence (HP:0001989) | 1.93893580 |
| 96 | Hypoventilation (HP:0002791) | 1.92111679 |
| 97 | Absent speech (HP:0001344) | 1.91433887 |
| 98 | Postural tremor (HP:0002174) | 1.90060696 |
| 99 | Amyotrophic lateral sclerosis (HP:0007354) | 1.86562218 |
| 100 | Generalized myoclonic seizures (HP:0002123) | 1.85203070 |
| 101 | Abnormal EKG (HP:0003115) | 1.85148586 |
| 102 | Prolonged QT interval (HP:0001657) | 1.84501426 |
| 103 | Rigidity (HP:0002063) | 1.84401952 |
| 104 | Incomplete penetrance (HP:0003829) | 1.83630038 |
| 105 | Lower limb asymmetry (HP:0100559) | 1.83594837 |
| 106 | Resting tremor (HP:0002322) | 1.82364538 |
| 107 | Rapidly progressive (HP:0003678) | 1.81334930 |
| 108 | Abnormality of saccadic eye movements (HP:0000570) | 1.81072068 |
| 109 | Psychosis (HP:0000709) | 1.80817023 |
| 110 | Anosmia (HP:0000458) | 1.78656806 |
| 111 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.78480748 |
| 112 | Delusions (HP:0000746) | 1.77089573 |
| 113 | Apathy (HP:0000741) | 1.76442257 |
| 114 | Spastic tetraplegia (HP:0002510) | 1.73481275 |
| 115 | Tetraplegia (HP:0002445) | 1.72321405 |
| 116 | Spinal canal stenosis (HP:0003416) | 1.71566879 |
| 117 | Memory impairment (HP:0002354) | 1.71000447 |
| 118 | Iris hypopigmentation (HP:0007730) | 1.68898621 |
| 119 | Unsteady gait (HP:0002317) | 1.68583718 |
| 120 | Split foot (HP:0001839) | 1.63132192 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.32851854 |
| 2 | MAP3K9 | 3.97174455 |
| 3 | EPHA4 | 3.91026090 |
| 4 | MARK1 | 3.00244275 |
| 5 | MAP3K4 | 2.74470400 |
| 6 | PRKD3 | 2.72930121 |
| 7 | DAPK2 | 2.71696837 |
| 8 | MINK1 | 2.66789569 |
| 9 | PAK6 | 2.47349769 |
| 10 | KSR2 | 2.30630960 |
| 11 | NTRK1 | 2.22445838 |
| 12 | CAMKK1 | 2.19218245 |
| 13 | NTRK2 | 2.03671896 |
| 14 | MAP2K7 | 2.00885017 |
| 15 | MAP2K4 | 1.66674736 |
| 16 | CDK5 | 1.62524691 |
| 17 | MAP3K2 | 1.56353170 |
| 18 | CAMKK2 | 1.53898280 |
| 19 | UHMK1 | 1.52861084 |
| 20 | ARAF | 1.47987603 |
| 21 | RIPK4 | 1.46981299 |
| 22 | GRK5 | 1.45751794 |
| 23 | KSR1 | 1.44233392 |
| 24 | STK38 | 1.44101845 |
| 25 | PRPF4B | 1.38812308 |
| 26 | DAPK1 | 1.38278757 |
| 27 | SIK2 | 1.34379966 |
| 28 | TYRO3 | 1.32326307 |
| 29 | PNCK | 1.29735740 |
| 30 | TNIK | 1.24238914 |
| 31 | PRKCG | 1.24104203 |
| 32 | CDK19 | 1.23911605 |
| 33 | MAP3K12 | 1.18437095 |
| 34 | MAPK13 | 1.14128484 |
| 35 | PHKG2 | 1.12054631 |
| 36 | PHKG1 | 1.12054631 |
| 37 | MAP3K11 | 1.10770256 |
| 38 | TAOK1 | 1.08934533 |
| 39 | PLK2 | 1.06380919 |
| 40 | PRKCH | 1.04985260 |
| 41 | STK11 | 1.00332508 |
| 42 | RET | 0.99931446 |
| 43 | SGK494 | 0.99472878 |
| 44 | SGK223 | 0.99472878 |
| 45 | FES | 0.98811580 |
| 46 | ALK | 0.97614470 |
| 47 | CAMK1 | 0.97063965 |
| 48 | MAP3K13 | 0.94681095 |
| 49 | PINK1 | 0.93031687 |
| 50 | CASK | 0.92432186 |
| 51 | CDK15 | 0.91561513 |
| 52 | CDK18 | 0.91002041 |
| 53 | CDK14 | 0.88738635 |
| 54 | CAMK2A | 0.88434326 |
| 55 | PKN1 | 0.85180340 |
| 56 | MAPK12 | 0.84390980 |
| 57 | PAK3 | 0.82650357 |
| 58 | CAMK2B | 0.81659042 |
| 59 | CDK11A | 0.80397938 |
| 60 | RIPK1 | 0.78201603 |
| 61 | MAP3K1 | 0.77888403 |
| 62 | MARK2 | 0.77867171 |
| 63 | CSNK1G2 | 0.75663143 |
| 64 | CAMK1G | 0.74409742 |
| 65 | LMTK2 | 0.73609504 |
| 66 | ICK | 0.72387418 |
| 67 | OXSR1 | 0.71276229 |
| 68 | LATS2 | 0.70946241 |
| 69 | PDPK1 | 0.69414791 |
| 70 | WNK1 | 0.69040313 |
| 71 | PDK1 | 0.68643853 |
| 72 | CDC42BPA | 0.68061259 |
| 73 | DYRK1A | 0.66350520 |
| 74 | SGK3 | 0.64627569 |
| 75 | SGK2 | 0.63444094 |
| 76 | BRAF | 0.62822583 |
| 77 | RAF1 | 0.61838566 |
| 78 | SGK1 | 0.61023114 |
| 79 | SCYL2 | 0.59551802 |
| 80 | CAMK4 | 0.57890874 |
| 81 | CAMK2D | 0.57517739 |
| 82 | BRSK1 | 0.56008874 |
| 83 | PRKCZ | 0.54732345 |
| 84 | RPS6KA3 | 0.52364702 |
| 85 | CAMK2G | 0.52230366 |
| 86 | FGFR2 | 0.51200070 |
| 87 | PTK2B | 0.51102244 |
| 88 | TNK2 | 0.49050698 |
| 89 | DYRK2 | 0.48098201 |
| 90 | NEK6 | 0.48084293 |
| 91 | MAPK10 | 0.48081973 |
| 92 | BMPR2 | 0.46946099 |
| 93 | FYN | 0.44984311 |
| 94 | MAP2K6 | 0.42697882 |
| 95 | LIMK1 | 0.42251332 |
| 96 | HIPK2 | 0.41940839 |
| 97 | PRKCE | 0.41185704 |
| 98 | PDGFRA | 0.40991502 |
| 99 | DAPK3 | 0.39982065 |
| 100 | PRKD2 | 0.39427428 |
| 101 | MAP2K1 | 0.39164491 |
| 102 | WNK3 | 0.38205630 |
| 103 | RPS6KA2 | 0.37682551 |
| 104 | FER | 0.37582548 |
| 105 | WNK4 | 0.37043914 |
| 106 | CAMK1D | 0.35729645 |
| 107 | PRKCA | 0.35601868 |
| 108 | ERBB2 | 0.33926368 |
| 109 | MAP3K7 | 0.33714762 |
| 110 | NEK1 | 0.31966812 |
| 111 | PRKCB | 0.31805209 |
| 112 | PRKG2 | 0.31777888 |
| 113 | MAPK8 | 0.30509199 |
| 114 | PRKG1 | 0.29566220 |
| 115 | PRKACA | 0.28685984 |
| 116 | INSRR | 0.28614654 |
| 117 | ROCK2 | 0.27488278 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.33097241 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 3.29283938 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 2.99053716 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 2.66700924 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.63744224 |
| 6 | Long-term potentiation_Homo sapiens_hsa04720 | 2.61626466 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.57412790 |
| 8 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.49366956 |
| 9 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.44292557 |
| 10 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.40794579 |
| 11 | Morphine addiction_Homo sapiens_hsa05032 | 2.38804999 |
| 12 | Insulin secretion_Homo sapiens_hsa04911 | 2.28315186 |
| 13 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.16544045 |
| 14 | Salivary secretion_Homo sapiens_hsa04970 | 2.07409381 |
| 15 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.94994504 |
| 16 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.88519793 |
| 17 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.88338471 |
| 18 | Taste transduction_Homo sapiens_hsa04742 | 1.80189937 |
| 19 | Cocaine addiction_Homo sapiens_hsa05030 | 1.77530680 |
| 20 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.74119678 |
| 21 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.68997323 |
| 22 | Long-term depression_Homo sapiens_hsa04730 | 1.64953053 |
| 23 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.54502467 |
| 24 | Renin secretion_Homo sapiens_hsa04924 | 1.52640373 |
| 25 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.52488074 |
| 26 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.51730317 |
| 27 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.45294118 |
| 28 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.44551737 |
| 29 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.43883887 |
| 30 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.42400333 |
| 31 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.40477801 |
| 32 | Gap junction_Homo sapiens_hsa04540 | 1.33997975 |
| 33 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.33993594 |
| 34 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.30005916 |
| 35 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.28686405 |
| 36 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.24919861 |
| 37 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.21714144 |
| 38 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.19929261 |
| 39 | Glioma_Homo sapiens_hsa05214 | 1.13690886 |
| 40 | Melanogenesis_Homo sapiens_hsa04916 | 1.02412296 |
| 41 | Axon guidance_Homo sapiens_hsa04360 | 1.00171482 |
| 42 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.99906649 |
| 43 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.98881018 |
| 44 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.98203281 |
| 45 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.98070770 |
| 46 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.97170497 |
| 47 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.92187643 |
| 48 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.91620539 |
| 49 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.89686224 |
| 50 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.89275152 |
| 51 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.89149205 |
| 52 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.87801823 |
| 53 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.86957152 |
| 54 | Phototransduction_Homo sapiens_hsa04744 | 0.86791256 |
| 55 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.84682366 |
| 56 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.83336062 |
| 57 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.74426000 |
| 58 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.70583306 |
| 59 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.68200743 |
| 60 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.67783848 |
| 61 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.67095368 |
| 62 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.65360629 |
| 63 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.65316083 |
| 64 | Bile secretion_Homo sapiens_hsa04976 | 0.65289429 |
| 65 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.63944627 |
| 66 | Alcoholism_Homo sapiens_hsa05034 | 0.62302544 |
| 67 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.61954562 |
| 68 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.61897539 |
| 69 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.59616916 |
| 70 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.56008413 |
| 71 | Endocytosis_Homo sapiens_hsa04144 | 0.55115555 |
| 72 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.53628368 |
| 73 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.52899949 |
| 74 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.52650081 |
| 75 | Prion diseases_Homo sapiens_hsa05020 | 0.52395642 |
| 76 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.51855031 |
| 77 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.51783402 |
| 78 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.49117933 |
| 79 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.49016695 |
| 80 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.47943288 |
| 81 | Endometrial cancer_Homo sapiens_hsa05213 | 0.47424467 |
| 82 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.47024880 |
| 83 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.46527690 |
| 84 | Circadian rhythm_Homo sapiens_hsa04710 | 0.45786045 |
| 85 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.44518624 |
| 86 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.43012195 |
| 87 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.43003712 |
| 88 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.41819099 |
| 89 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.41615653 |
| 90 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.41473458 |
| 91 | Alzheimers disease_Homo sapiens_hsa05010 | 0.40638334 |
| 92 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.37460580 |
| 93 | Mineral absorption_Homo sapiens_hsa04978 | 0.37355272 |
| 94 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.36673478 |
| 95 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.36459811 |
| 96 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.35096866 |
| 97 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.32493896 |
| 98 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.32082703 |
| 99 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.31935157 |
| 100 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.30923817 |
| 101 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.29669449 |
| 102 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.28682486 |
| 103 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.28560788 |
| 104 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.26607796 |
| 105 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.26221700 |
| 106 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.24806997 |
| 107 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.24689383 |
| 108 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.24067901 |
| 109 | Histidine metabolism_Homo sapiens_hsa00340 | 0.21877518 |
| 110 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.20098159 |
| 111 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.18146457 |

