RUNDC3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.31874013
2synaptic vesicle maturation (GO:0016188)6.28610974
3locomotory exploration behavior (GO:0035641)5.92371314
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.89536162
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.49495547
6synaptic vesicle exocytosis (GO:0016079)5.30716815
7glutamate secretion (GO:0014047)5.20840947
8vocalization behavior (GO:0071625)5.17389646
9regulation of synaptic vesicle exocytosis (GO:2000300)5.12245466
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.06770027
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.87782133
12regulation of glutamate receptor signaling pathway (GO:1900449)4.69425649
13neuronal action potential propagation (GO:0019227)4.55951507
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.55746056
15regulation of synaptic vesicle transport (GO:1902803)4.55160484
16protein localization to synapse (GO:0035418)4.54230421
17neurotransmitter secretion (GO:0007269)4.54069285
18L-amino acid import (GO:0043092)4.51240411
19regulation of neuronal synaptic plasticity (GO:0048168)4.50298717
20cerebellar granule cell differentiation (GO:0021707)4.50167525
21exploration behavior (GO:0035640)4.43041256
22layer formation in cerebral cortex (GO:0021819)4.37117908
23neuron cell-cell adhesion (GO:0007158)4.34021996
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.29686092
25regulation of synapse structural plasticity (GO:0051823)4.22003495
26negative regulation of synaptic transmission, GABAergic (GO:0032229)4.21745020
27synaptic transmission, glutamatergic (GO:0035249)4.18441018
28axon ensheathment in central nervous system (GO:0032291)4.07504223
29central nervous system myelination (GO:0022010)4.07504223
30dendritic spine morphogenesis (GO:0060997)4.02465247
31gamma-aminobutyric acid transport (GO:0015812)3.98123936
32potassium ion homeostasis (GO:0055075)3.97748088
33glutamate receptor signaling pathway (GO:0007215)3.92953641
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.89024169
35amino acid import (GO:0043090)3.88990474
36cellular potassium ion homeostasis (GO:0030007)3.86309807
37potassium ion import (GO:0010107)3.82532941
38neuron-neuron synaptic transmission (GO:0007270)3.81180908
39neurotransmitter-gated ion channel clustering (GO:0072578)3.80386006
40regulation of voltage-gated calcium channel activity (GO:1901385)3.78094948
41regulation of synapse maturation (GO:0090128)3.76343219
42positive regulation of membrane potential (GO:0045838)3.75428568
43long-term memory (GO:0007616)3.74734749
44activation of protein kinase A activity (GO:0034199)3.73431892
45proline transport (GO:0015824)3.71344495
46sodium ion export (GO:0071436)3.70514190
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.68972501
48neurotransmitter transport (GO:0006836)3.64630768
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.64114459
50negative regulation of dendrite morphogenesis (GO:0050774)3.61982790
51neuromuscular process controlling balance (GO:0050885)3.56647626
52cerebellar Purkinje cell differentiation (GO:0021702)3.56028858
53positive regulation of dendritic spine morphogenesis (GO:0061003)3.55252162
54synaptic vesicle endocytosis (GO:0048488)3.50532888
55regulation of synaptic plasticity (GO:0048167)3.50014064
56regulation of postsynaptic membrane potential (GO:0060078)3.49320819
57regulation of neurotransmitter secretion (GO:0046928)3.47900640
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.45963815
59neuromuscular synaptic transmission (GO:0007274)3.44901909
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44685378
61transmission of nerve impulse (GO:0019226)3.44402350
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.44363330
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.41553936
64neuromuscular process controlling posture (GO:0050884)3.41413525
65regulation of neurotransmitter levels (GO:0001505)3.38802526
66regulation of dendritic spine morphogenesis (GO:0061001)3.38737306
67neuron recognition (GO:0008038)3.36801664
68glycine transport (GO:0015816)3.36393229
69dendrite morphogenesis (GO:0048813)3.32238514
70cell communication by electrical coupling (GO:0010644)3.31515116
71positive regulation of synapse maturation (GO:0090129)3.28460528
72cell differentiation in hindbrain (GO:0021533)3.26530448
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.26405322
74auditory behavior (GO:0031223)3.26127976
75cellular sodium ion homeostasis (GO:0006883)3.24387201
76neuronal ion channel clustering (GO:0045161)3.24006428
77acidic amino acid transport (GO:0015800)3.23029387
78membrane depolarization during action potential (GO:0086010)3.22686789
79regulation of neurotransmitter transport (GO:0051588)3.22233659
80prepulse inhibition (GO:0060134)3.22057641
81regulation of vesicle fusion (GO:0031338)3.20771713
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.20365111
83presynaptic membrane organization (GO:0097090)3.20111529
84neurotransmitter uptake (GO:0001504)3.19972263
85axonal fasciculation (GO:0007413)3.16706871
86chemosensory behavior (GO:0007635)3.15921624
87long-term synaptic potentiation (GO:0060291)3.15205839
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14783223
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.12172841
90positive regulation of neurotransmitter transport (GO:0051590)3.11179607
91membrane depolarization (GO:0051899)3.11118132
92regulation of ARF protein signal transduction (GO:0032012)3.11087891
93establishment of synaptic vesicle localization (GO:0097480)3.10138031
94synaptic vesicle transport (GO:0048489)3.10138031
95response to auditory stimulus (GO:0010996)3.08815255
96cerebellar Purkinje cell layer development (GO:0021680)3.08723870
97positive regulation of dendritic spine development (GO:0060999)3.07769598
98innervation (GO:0060384)3.07742569
99mating behavior (GO:0007617)3.07596457
100membrane hyperpolarization (GO:0060081)3.06551675
101regulation of exocytosis (GO:0017157)3.06016714
102gamma-aminobutyric acid signaling pathway (GO:0007214)3.05295718
103positive regulation of neurotransmitter secretion (GO:0001956)3.05283275
104vesicle transport along microtubule (GO:0047496)3.05137271
105presynaptic membrane assembly (GO:0097105)3.04705479
106cell migration in hindbrain (GO:0021535)3.03594768
107postsynaptic membrane organization (GO:0001941)3.02990436
108dendritic spine organization (GO:0097061)3.01937956
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00302141
110positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99721709
111signal release (GO:0023061)2.98459303
112G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98324649
113regulation of calcium ion-dependent exocytosis (GO:0017158)2.95630067
114regulation of synaptic transmission (GO:0050804)2.94389909
115social behavior (GO:0035176)2.93037011
116intraspecies interaction between organisms (GO:0051703)2.93037011
117neuromuscular process (GO:0050905)2.91827859
118learning (GO:0007612)2.89435953
119response to pheromone (GO:0019236)2.89307504
120positive regulation of synaptic transmission (GO:0050806)2.88842724
121synaptic transmission (GO:0007268)2.88724623
122synapse assembly (GO:0007416)2.88460894
123regulation of dendritic spine development (GO:0060998)2.87741331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.04090744
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08103087
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01400893
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00305863
5* REST_21632747_ChIP-Seq_MESCs_Mouse2.96173081
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.90260347
7GBX2_23144817_ChIP-Seq_PC3_Human2.88706160
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77309703
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77309703
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73056684
11DROSHA_22980978_ChIP-Seq_HELA_Human2.71821578
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64335597
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60180561
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50430263
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48832212
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.47426649
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.46679731
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46115206
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.42073586
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40739054
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.34199525
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.27106769
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.25088862
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24401200
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20135987
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.19779915
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15924610
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.82650567
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72905409
30* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51751251
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51120205
32AR_21572438_ChIP-Seq_LNCaP_Human1.46871481
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40955818
34RING1B_27294783_Chip-Seq_ESCs_Mouse1.40914063
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40603554
36* KDM2B_26808549_Chip-Seq_K562_Human1.39793407
37ZNF274_21170338_ChIP-Seq_K562_Hela1.39367474
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38197032
39SMAD4_21799915_ChIP-Seq_A2780_Human1.37399484
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30841894
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29008760
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27710082
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27206170
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22624116
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22233544
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21018489
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.20736324
48AR_19668381_ChIP-Seq_PC3_Human1.19540981
49* RING1B_27294783_Chip-Seq_NPCs_Mouse1.18849213
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16958333
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16476572
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15307974
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14216213
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13683920
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11629700
56TAF15_26573619_Chip-Seq_HEK293_Human1.10786583
57OCT4_19829295_ChIP-Seq_ESCs_Human1.10392434
58STAT3_23295773_ChIP-Seq_U87_Human1.08523759
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08415575
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06283600
61* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06249399
62CTCF_27219007_Chip-Seq_Bcells_Human1.04302113
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.04039301
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.03566061
65TET1_21490601_ChIP-Seq_MESCs_Mouse1.02551925
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02495544
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01758394
68AR_25329375_ChIP-Seq_VCAP_Human1.00079095
69CBX2_27304074_Chip-Seq_ESCs_Mouse0.99831726
70P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99326360
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98601913
72BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98497238
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98210435
74LXR_22292898_ChIP-Seq_THP-1_Human0.97838337
75* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97068235
76SMAD3_21741376_ChIP-Seq_ESCs_Human0.96584876
77YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96484673
78* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96057447
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95937753
80DPY_21335234_ChIP-Seq_ESCs_Mouse0.94897949
81TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94558248
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93809627
83P300_19829295_ChIP-Seq_ESCs_Human0.93766228
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93196626
85ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92807288
86TCF4_23295773_ChIP-Seq_U87_Human0.91570274
87SMC4_20622854_ChIP-Seq_HELA_Human0.91530322
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91259709
89SMAD4_21741376_ChIP-Seq_HESCs_Human0.90767082
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89063393
91ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88901258
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.87710531
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87457154
94RNF2_27304074_Chip-Seq_NSC_Mouse0.87360581
95AHR_22903824_ChIP-Seq_MCF-7_Human0.86972646
96IGF1R_20145208_ChIP-Seq_DFB_Human0.85624161
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.85501629
98P68_20966046_ChIP-Seq_HELA_Human0.85493656
99* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84978057
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84295054
101KLF4_19829295_ChIP-Seq_ESCs_Human0.83969577
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82701990
103SMAD3_21741376_ChIP-Seq_HESCs_Human0.82210415
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81128249
105SMAD4_21741376_ChIP-Seq_ESCs_Human0.80907262
106CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79792051
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79119994
108* RUNX2_22187159_ChIP-Seq_PCA_Human0.78968344
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78605471
110* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77926789
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77867124
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77397434
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77325473
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76619315
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76403107
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76403107
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.76374991
118CREB1_26743006_Chip-Seq_LNCaP_Human0.76147862
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.74418988
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74401720
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.73817758
122RUNX1_26923725_Chip-Seq_HPCs_Mouse0.69427906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.58528073
2MP0003880_abnormal_central_pattern4.22502842
3MP0003635_abnormal_synaptic_transmissio4.11020166
4MP0004270_analgesia3.90975874
5MP0009745_abnormal_behavioral_response3.27671533
6MP0002063_abnormal_learning/memory/cond3.23600890
7MP0002064_seizures3.08139643
8MP0005423_abnormal_somatic_nervous3.01024236
9MP0009046_muscle_twitch2.94526990
10MP0001968_abnormal_touch/_nociception2.86138472
11MP0002822_catalepsy2.84820145
12MP0002734_abnormal_mechanical_nocicepti2.70737072
13MP0002572_abnormal_emotion/affect_behav2.67771078
14MP0002272_abnormal_nervous_system2.63133213
15MP0001486_abnormal_startle_reflex2.46485319
16MP0002909_abnormal_adrenal_gland2.32948385
17MP0002736_abnormal_nociception_after2.17940471
18MP0002735_abnormal_chemical_nociception2.17381116
19MP0001501_abnormal_sleep_pattern2.16550482
20MP0002733_abnormal_thermal_nociception2.12833080
21MP0009780_abnormal_chondrocyte_physiolo2.08014263
22MP0004858_abnormal_nervous_system2.04889505
23MP0001440_abnormal_grooming_behavior2.02744779
24MP0001970_abnormal_pain_threshold1.99805595
25MP0003329_amyloid_beta_deposits1.99470385
26MP0008569_lethality_at_weaning1.98896036
27MP0002067_abnormal_sensory_capabilities1.90859076
28MP0001984_abnormal_olfaction1.90413923
29MP0002184_abnormal_innervation1.87522581
30MP0004811_abnormal_neuron_physiology1.84971349
31MP0004885_abnormal_endolymph1.82601308
32MP0002557_abnormal_social/conspecific_i1.78079771
33MP0001986_abnormal_taste_sensitivity1.76835791
34MP0000955_abnormal_spinal_cord1.74312081
35MP0000778_abnormal_nervous_system1.70065666
36MP0005386_behavior/neurological_phenoty1.60429852
37MP0004924_abnormal_behavior1.60429852
38MP0005646_abnormal_pituitary_gland1.57687659
39MP0006276_abnormal_autonomic_nervous1.56110189
40MP0003123_paternal_imprinting1.56095156
41MP0005645_abnormal_hypothalamus_physiol1.52534199
42MP0002882_abnormal_neuron_morphology1.49894276
43MP0003879_abnormal_hair_cell1.49342563
44MP0003283_abnormal_digestive_organ1.47343696
45MP0002066_abnormal_motor_capabilities/c1.44428318
46MP0003633_abnormal_nervous_system1.36519680
47MP0003787_abnormal_imprinting1.35176672
48MP0001502_abnormal_circadian_rhythm1.32821740
49MP0004147_increased_porphyrin_level1.31019759
50MP0004142_abnormal_muscle_tone1.20894644
51MP0003631_nervous_system_phenotype1.15111041
52MP0000013_abnormal_adipose_tissue1.13941404
53MP0002152_abnormal_brain_morphology1.13425224
54MP0003122_maternal_imprinting1.12354623
55MP0002229_neurodegeneration1.11318534
56MP0008961_abnormal_basal_metabolism1.10440087
57MP0004145_abnormal_muscle_electrophysio1.07150426
58MP0001905_abnormal_dopamine_level1.04863449
59MP0001529_abnormal_vocalization1.03805003
60MP0008877_abnormal_DNA_methylation1.02353062
61MP0002069_abnormal_eating/drinking_beha1.01317386
62MP0003634_abnormal_glial_cell0.97471936
63MP0004742_abnormal_vestibular_system0.96612236
64MP0004043_abnormal_pH_regulation0.96068147
65MP0005551_abnormal_eye_electrophysiolog0.93969812
66MP0008872_abnormal_physiological_respon0.92465435
67MP0005394_taste/olfaction_phenotype0.91355351
68MP0005499_abnormal_olfactory_system0.91355351
69MP0003075_altered_response_to0.91127513
70MP0003690_abnormal_glial_cell0.90666845
71MP0000920_abnormal_myelination0.90197137
72MP0010386_abnormal_urinary_bladder0.89849779
73MP0003632_abnormal_nervous_system0.89279733
74MP0005535_abnormal_body_temperature0.85659847
75MP0000604_amyloidosis0.84516784
76MP0003121_genomic_imprinting0.82987033
77MP0008874_decreased_physiological_sensi0.81355633
78MP0000631_abnormal_neuroendocrine_gland0.81321507
79MP0002752_abnormal_somatic_nervous0.80765118
80MP0001177_atelectasis0.80334350
81MP0004085_abnormal_heartbeat0.79297255
82MP0002638_abnormal_pupillary_reflex0.78923371
83MP0001485_abnormal_pinna_reflex0.77960211
84MP0001963_abnormal_hearing_physiology0.76308636
85MP0000569_abnormal_digit_pigmentation0.75991955
86MP0005167_abnormal_blood-brain_barrier0.75588100
87MP0000751_myopathy0.75332911
88MP0001299_abnormal_eye_distance/0.72789400
89MP0001348_abnormal_lacrimal_gland0.72647698
90MP0006072_abnormal_retinal_apoptosis0.72156923
91MP0002653_abnormal_ependyma_morphology0.71118823
92MP0003183_abnormal_peptide_metabolism0.68932973
93MP0004130_abnormal_muscle_cell0.68166739
94MP0002090_abnormal_vision0.68031254
95MP0003172_abnormal_lysosome_physiology0.67264177
96MP0001188_hyperpigmentation0.66490227
97MP0003137_abnormal_impulse_conducting0.63801672
98MP0002837_dystrophic_cardiac_calcinosis0.60067685
99MP0001664_abnormal_digestion0.58324337
100MP0003861_abnormal_nervous_system0.57598706
101MP0005187_abnormal_penis_morphology0.56348727
102MP0001346_abnormal_lacrimal_gland0.55330327
103MP0001943_abnormal_respiration0.55210788
104MP0010769_abnormal_survival0.54342301
105MP0000026_abnormal_inner_ear0.53700965
106MP0004233_abnormal_muscle_weight0.53382187
107MP0004510_myositis0.53160558
108MP0005623_abnormal_meninges_morphology0.52979559
109MP0002234_abnormal_pharynx_morphology0.52436569
110MP0002876_abnormal_thyroid_physiology0.51348974
111MP0010768_mortality/aging0.49963634
112MP0010770_preweaning_lethality0.48962531
113MP0002082_postnatal_lethality0.48962531
114MP0003956_abnormal_body_size0.48554973
115MP0001765_abnormal_ion_homeostasis0.46829567
116MP0000639_abnormal_adrenal_gland0.43303126
117MP0002873_normal_phenotype0.41955189
118MP0003878_abnormal_ear_physiology0.41766576
119MP0005377_hearing/vestibular/ear_phenot0.41766576

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.15550745
2Focal motor seizures (HP:0011153)6.66909115
3Visual hallucinations (HP:0002367)5.43955084
4Focal seizures (HP:0007359)5.31451047
5Action tremor (HP:0002345)4.37729274
6Atonic seizures (HP:0010819)4.35087877
7Progressive cerebellar ataxia (HP:0002073)4.21982061
8Epileptic encephalopathy (HP:0200134)4.16413153
9Supranuclear gaze palsy (HP:0000605)3.98716195
10Febrile seizures (HP:0002373)3.95215653
11Absence seizures (HP:0002121)3.80739529
12Ankle clonus (HP:0011448)3.60480470
13Generalized tonic-clonic seizures (HP:0002069)3.58880538
14Dialeptic seizures (HP:0011146)3.44097347
15Depression (HP:0000716)3.43246105
16Cerebral hypomyelination (HP:0006808)3.28852205
17Impaired vibration sensation in the lower limbs (HP:0002166)3.28094244
18Dysdiadochokinesis (HP:0002075)3.16915569
19Poor eye contact (HP:0000817)3.16545453
20Gaze-evoked nystagmus (HP:0000640)3.14677386
21Akinesia (HP:0002304)3.14282979
22Dysmetria (HP:0001310)3.12891148
23Papilledema (HP:0001085)3.08952621
24Anxiety (HP:0000739)3.08106900
25Broad-based gait (HP:0002136)3.04532606
26Urinary bladder sphincter dysfunction (HP:0002839)2.99825986
27Postural instability (HP:0002172)2.98791232
28Truncal ataxia (HP:0002078)2.93364917
29Amblyopia (HP:0000646)2.91581659
30Abnormality of the lower motor neuron (HP:0002366)2.91531020
31Impaired social interactions (HP:0000735)2.89749671
32Abnormal social behavior (HP:0012433)2.89749671
33Neurofibrillary tangles (HP:0002185)2.85835448
34Abnormal eating behavior (HP:0100738)2.82773016
35Impaired smooth pursuit (HP:0007772)2.77228408
36Intention tremor (HP:0002080)2.76764513
37Genetic anticipation (HP:0003743)2.76135515
38Spastic gait (HP:0002064)2.75697116
39Ventricular fibrillation (HP:0001663)2.73506025
40Mutism (HP:0002300)2.71714987
41Cerebral inclusion bodies (HP:0100314)2.71193954
42Hemiparesis (HP:0001269)2.70219475
43Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.64283843
44Urinary urgency (HP:0000012)2.63579355
45Polyphagia (HP:0002591)2.63541531
46Megalencephaly (HP:0001355)2.63307141
47Pheochromocytoma (HP:0002666)2.62928049
48Torticollis (HP:0000473)2.61923812
49Agitation (HP:0000713)2.59060323
50Sleep apnea (HP:0010535)2.58550695
51Insomnia (HP:0100785)2.55105179
52Hemiplegia (HP:0002301)2.53212426
53Peripheral hypomyelination (HP:0007182)2.52997881
54Scanning speech (HP:0002168)2.46489702
55Focal dystonia (HP:0004373)2.43402535
56Annular pancreas (HP:0001734)2.42708226
57Bradykinesia (HP:0002067)2.41005781
58Epileptiform EEG discharges (HP:0011182)2.40434401
59EEG with generalized epileptiform discharges (HP:0011198)2.39426715
60Abnormality of binocular vision (HP:0011514)2.38493453
61Diplopia (HP:0000651)2.38493453
62Abnormality of ocular smooth pursuit (HP:0000617)2.37647694
63Insidious onset (HP:0003587)2.35936637
64Termporal pattern (HP:0011008)2.35936637
65Increased circulating renin level (HP:0000848)2.35488733
66Abnormality of the corticospinal tract (HP:0002492)2.35264226
67Limb dystonia (HP:0002451)2.34913313
68Hypsarrhythmia (HP:0002521)2.34062484
69Hyperventilation (HP:0002883)2.33120045
70Morphological abnormality of the pyramidal tract (HP:0002062)2.31682334
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.31587353
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31587353
73Excessive salivation (HP:0003781)2.27389908
74Drooling (HP:0002307)2.27389908
75Progressive inability to walk (HP:0002505)2.25741289
76Stereotypic behavior (HP:0000733)2.25598382
77Spastic tetraparesis (HP:0001285)2.24296009
78Bundle branch block (HP:0011710)2.23479795
79Neuroendocrine neoplasm (HP:0100634)2.22389066
80Lower limb muscle weakness (HP:0007340)2.20834431
81Dysmetric saccades (HP:0000641)2.19324206
82Impaired vibratory sensation (HP:0002495)2.18650904
83Craniofacial dystonia (HP:0012179)2.14930224
84Choreoathetosis (HP:0001266)2.14734651
85Status epilepticus (HP:0002133)2.12716482
86Pointed chin (HP:0000307)2.10672912
87CNS hypomyelination (HP:0003429)2.09047252
88Clonus (HP:0002169)2.07821201
89Neuronal loss in central nervous system (HP:0002529)2.04534817
90Diminished motivation (HP:0000745)2.03092183
91Gait ataxia (HP:0002066)1.97092684
92Failure to thrive in infancy (HP:0001531)1.95356181
93Hypercortisolism (HP:0001578)1.95058067
94Obstructive sleep apnea (HP:0002870)1.94655767
95Fetal akinesia sequence (HP:0001989)1.93893580
96Hypoventilation (HP:0002791)1.92111679
97Absent speech (HP:0001344)1.91433887
98Postural tremor (HP:0002174)1.90060696
99Amyotrophic lateral sclerosis (HP:0007354)1.86562218
100Generalized myoclonic seizures (HP:0002123)1.85203070
101Abnormal EKG (HP:0003115)1.85148586
102Prolonged QT interval (HP:0001657)1.84501426
103Rigidity (HP:0002063)1.84401952
104Incomplete penetrance (HP:0003829)1.83630038
105Lower limb asymmetry (HP:0100559)1.83594837
106Resting tremor (HP:0002322)1.82364538
107Rapidly progressive (HP:0003678)1.81334930
108Abnormality of saccadic eye movements (HP:0000570)1.81072068
109Psychosis (HP:0000709)1.80817023
110Anosmia (HP:0000458)1.78656806
111Neoplasm of the peripheral nervous system (HP:0100007)1.78480748
112Delusions (HP:0000746)1.77089573
113Apathy (HP:0000741)1.76442257
114Spastic tetraplegia (HP:0002510)1.73481275
115Tetraplegia (HP:0002445)1.72321405
116Spinal canal stenosis (HP:0003416)1.71566879
117Memory impairment (HP:0002354)1.71000447
118Iris hypopigmentation (HP:0007730)1.68898621
119Unsteady gait (HP:0002317)1.68583718
120Split foot (HP:0001839)1.63132192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.32851854
2MAP3K93.97174455
3EPHA43.91026090
4MARK13.00244275
5MAP3K42.74470400
6PRKD32.72930121
7DAPK22.71696837
8MINK12.66789569
9PAK62.47349769
10KSR22.30630960
11NTRK12.22445838
12CAMKK12.19218245
13NTRK22.03671896
14MAP2K72.00885017
15MAP2K41.66674736
16CDK51.62524691
17MAP3K21.56353170
18CAMKK21.53898280
19UHMK11.52861084
20ARAF1.47987603
21RIPK41.46981299
22GRK51.45751794
23KSR11.44233392
24STK381.44101845
25PRPF4B1.38812308
26DAPK11.38278757
27SIK21.34379966
28TYRO31.32326307
29PNCK1.29735740
30TNIK1.24238914
31PRKCG1.24104203
32CDK191.23911605
33MAP3K121.18437095
34MAPK131.14128484
35PHKG11.12054631
36PHKG21.12054631
37MAP3K111.10770256
38TAOK11.08934533
39PLK21.06380919
40PRKCH1.04985260
41STK111.00332508
42RET0.99931446
43SGK2230.99472878
44SGK4940.99472878
45FES0.98811580
46ALK0.97614470
47CAMK10.97063965
48MAP3K130.94681095
49PINK10.93031687
50CASK0.92432186
51CDK150.91561513
52CDK180.91002041
53CDK140.88738635
54CAMK2A0.88434326
55PKN10.85180340
56MAPK120.84390980
57PAK30.82650357
58CAMK2B0.81659042
59CDK11A0.80397938
60RIPK10.78201603
61MAP3K10.77888403
62MARK20.77867171
63CSNK1G20.75663143
64CAMK1G0.74409742
65LMTK20.73609504
66ICK0.72387418
67OXSR10.71276229
68LATS20.70946241
69PDPK10.69414791
70WNK10.69040313
71PDK10.68643853
72CDC42BPA0.68061259
73DYRK1A0.66350520
74SGK30.64627569
75SGK20.63444094
76BRAF0.62822583
77RAF10.61838566
78SGK10.61023114
79SCYL20.59551802
80CAMK40.57890874
81CAMK2D0.57517739
82BRSK10.56008874
83PRKCZ0.54732345
84RPS6KA30.52364702
85CAMK2G0.52230366
86FGFR20.51200070
87PTK2B0.51102244
88TNK20.49050698
89DYRK20.48098201
90NEK60.48084293
91MAPK100.48081973
92BMPR20.46946099
93FYN0.44984311
94MAP2K60.42697882
95LIMK10.42251332
96HIPK20.41940839
97PRKCE0.41185704
98PDGFRA0.40991502
99DAPK30.39982065
100PRKD20.39427428
101MAP2K10.39164491
102WNK30.38205630
103RPS6KA20.37682551
104FER0.37582548
105WNK40.37043914
106CAMK1D0.35729645
107PRKCA0.35601868
108ERBB20.33926368
109MAP3K70.33714762
110NEK10.31966812
111PRKCB0.31805209
112PRKG20.31777888
113MAPK80.30509199
114PRKG10.29566220
115PRKACA0.28685984
116INSRR0.28614654
117ROCK20.27488278

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.33097241
2Nicotine addiction_Homo sapiens_hsa050333.29283938
3Olfactory transduction_Homo sapiens_hsa047402.99053716
4GABAergic synapse_Homo sapiens_hsa047272.66700924
5Circadian entrainment_Homo sapiens_hsa047132.63744224
6Long-term potentiation_Homo sapiens_hsa047202.61626466
7Glutamatergic synapse_Homo sapiens_hsa047242.57412790
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49366956
9Amphetamine addiction_Homo sapiens_hsa050312.44292557
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.40794579
11Morphine addiction_Homo sapiens_hsa050322.38804999
12Insulin secretion_Homo sapiens_hsa049112.28315186
13Dopaminergic synapse_Homo sapiens_hsa047282.16544045
14Salivary secretion_Homo sapiens_hsa049702.07409381
15Cholinergic synapse_Homo sapiens_hsa047251.94994504
16Gastric acid secretion_Homo sapiens_hsa049711.88519793
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88338471
18Taste transduction_Homo sapiens_hsa047421.80189937
19Cocaine addiction_Homo sapiens_hsa050301.77530680
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74119678
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68997323
22Long-term depression_Homo sapiens_hsa047301.64953053
23Oxytocin signaling pathway_Homo sapiens_hsa049211.54502467
24Renin secretion_Homo sapiens_hsa049241.52640373
25Vitamin B6 metabolism_Homo sapiens_hsa007501.52488074
26Serotonergic synapse_Homo sapiens_hsa047261.51730317
27GnRH signaling pathway_Homo sapiens_hsa049121.45294118
28Type II diabetes mellitus_Homo sapiens_hsa049301.44551737
29Nitrogen metabolism_Homo sapiens_hsa009101.43883887
30Calcium signaling pathway_Homo sapiens_hsa040201.42400333
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40477801
32Gap junction_Homo sapiens_hsa045401.33997975
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33993594
34Collecting duct acid secretion_Homo sapiens_hsa049661.30005916
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28686405
36cAMP signaling pathway_Homo sapiens_hsa040241.24919861
37Estrogen signaling pathway_Homo sapiens_hsa049151.21714144
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19929261
39Glioma_Homo sapiens_hsa052141.13690886
40Melanogenesis_Homo sapiens_hsa049161.02412296
41Axon guidance_Homo sapiens_hsa043601.00171482
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99906649
43Pancreatic secretion_Homo sapiens_hsa049720.98881018
44ErbB signaling pathway_Homo sapiens_hsa040120.98203281
45Vibrio cholerae infection_Homo sapiens_hsa051100.98070770
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97170497
47Cardiac muscle contraction_Homo sapiens_hsa042600.92187643
48Dorso-ventral axis formation_Homo sapiens_hsa043200.91620539
49Thyroid hormone synthesis_Homo sapiens_hsa049180.89686224
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89275152
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.89149205
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.87801823
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86957152
54Phototransduction_Homo sapiens_hsa047440.86791256
55Oocyte meiosis_Homo sapiens_hsa041140.84682366
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83336062
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74426000
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.70583306
59Type I diabetes mellitus_Homo sapiens_hsa049400.68200743
60Choline metabolism in cancer_Homo sapiens_hsa052310.67783848
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67095368
62MAPK signaling pathway_Homo sapiens_hsa040100.65360629
63Glucagon signaling pathway_Homo sapiens_hsa049220.65316083
64Bile secretion_Homo sapiens_hsa049760.65289429
65VEGF signaling pathway_Homo sapiens_hsa043700.63944627
66Alcoholism_Homo sapiens_hsa050340.62302544
67mTOR signaling pathway_Homo sapiens_hsa041500.61954562
68Dilated cardiomyopathy_Homo sapiens_hsa054140.61897539
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59616916
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56008413
71Endocytosis_Homo sapiens_hsa041440.55115555
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53628368
73Inositol phosphate metabolism_Homo sapiens_hsa005620.52899949
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52650081
75Prion diseases_Homo sapiens_hsa050200.52395642
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51855031
77Ras signaling pathway_Homo sapiens_hsa040140.51783402
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.49117933
79Rap1 signaling pathway_Homo sapiens_hsa040150.49016695
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47943288
81Endometrial cancer_Homo sapiens_hsa052130.47424467
82Insulin signaling pathway_Homo sapiens_hsa049100.47024880
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46527690
84Circadian rhythm_Homo sapiens_hsa047100.45786045
85Non-small cell lung cancer_Homo sapiens_hsa052230.44518624
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43012195
87Renal cell carcinoma_Homo sapiens_hsa052110.43003712
88Regulation of autophagy_Homo sapiens_hsa041400.41819099
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41615653
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41473458
91Alzheimers disease_Homo sapiens_hsa050100.40638334
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37460580
93Mineral absorption_Homo sapiens_hsa049780.37355272
94Ovarian steroidogenesis_Homo sapiens_hsa049130.36673478
95Fatty acid biosynthesis_Homo sapiens_hsa000610.36459811
96Wnt signaling pathway_Homo sapiens_hsa043100.35096866
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32493896
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32082703
99Arginine and proline metabolism_Homo sapiens_hsa003300.31935157
100Chemokine signaling pathway_Homo sapiens_hsa040620.30923817
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.29669449
102Prolactin signaling pathway_Homo sapiens_hsa049170.28682486
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.28560788
104Arginine biosynthesis_Homo sapiens_hsa002200.26607796
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26221700
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24806997
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24689383
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.24067901
109Histidine metabolism_Homo sapiens_hsa003400.21877518
110AMPK signaling pathway_Homo sapiens_hsa041520.20098159
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18146457

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