RUNDC3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.68236582
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.60373849
3synaptic vesicle maturation (GO:0016188)5.34165961
4layer formation in cerebral cortex (GO:0021819)5.20806027
5neuron cell-cell adhesion (GO:0007158)5.15050420
6synaptic vesicle exocytosis (GO:0016079)5.13456341
7vocalization behavior (GO:0071625)5.10167478
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.05467934
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.04026149
10locomotory exploration behavior (GO:0035641)4.81537754
11regulation of synaptic vesicle exocytosis (GO:2000300)4.81411804
12protein localization to synapse (GO:0035418)4.78057518
13regulation of glutamate receptor signaling pathway (GO:1900449)4.74654987
14glutamate secretion (GO:0014047)4.70019024
15negative regulation of synaptic transmission, GABAergic (GO:0032229)4.62916493
16exploration behavior (GO:0035640)4.36690260
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.31719156
18regulation of synaptic vesicle transport (GO:1902803)4.24023748
19neuron recognition (GO:0008038)4.17814528
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.17602603
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.14796310
22dendritic spine morphogenesis (GO:0060997)4.13817783
23glutamate receptor signaling pathway (GO:0007215)4.01863564
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.98133949
25regulation of neuronal synaptic plasticity (GO:0048168)3.97091571
26neurotransmitter secretion (GO:0007269)3.96248581
27synaptic transmission, glutamatergic (GO:0035249)3.90280964
28regulation of synapse structural plasticity (GO:0051823)3.86506215
29neuron-neuron synaptic transmission (GO:0007270)3.81111625
30axonal fasciculation (GO:0007413)3.80313212
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71465609
32proline transport (GO:0015824)3.71278366
33neuronal action potential propagation (GO:0019227)3.59616243
34neurotransmitter-gated ion channel clustering (GO:0072578)3.58762575
35establishment of mitochondrion localization (GO:0051654)3.58242726
36positive regulation of synapse maturation (GO:0090129)3.57571001
37dendrite morphogenesis (GO:0048813)3.56194036
38neurofilament cytoskeleton organization (GO:0060052)3.50163073
39regulation of dendritic spine morphogenesis (GO:0061001)3.46465505
40behavioral response to nicotine (GO:0035095)3.46389120
41postsynaptic membrane organization (GO:0001941)3.44455973
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43902062
43activation of protein kinase A activity (GO:0034199)3.43109539
44positive regulation of membrane potential (GO:0045838)3.42999267
45long-term memory (GO:0007616)3.41308222
46positive regulation of synaptic transmission, GABAergic (GO:0032230)3.39499998
47regulation of postsynaptic membrane potential (GO:0060078)3.37320831
48membrane depolarization during action potential (GO:0086010)3.35652996
49response to histamine (GO:0034776)3.34985192
50transmission of nerve impulse (GO:0019226)3.34006147
51gamma-aminobutyric acid transport (GO:0015812)3.32925662
52cell migration in hindbrain (GO:0021535)3.32574642
53synaptic vesicle endocytosis (GO:0048488)3.31954125
54G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.31288079
55detection of calcium ion (GO:0005513)3.30588520
56regulation of vesicle fusion (GO:0031338)3.30082566
57vesicle transport along microtubule (GO:0047496)3.26770494
58central nervous system projection neuron axonogenesis (GO:0021952)3.26253196
59pyrimidine nucleobase catabolic process (GO:0006208)3.26087455
60presynaptic membrane assembly (GO:0097105)3.25708830
61cerebellar Purkinje cell differentiation (GO:0021702)3.23830870
62regulation of synaptic plasticity (GO:0048167)3.23548678
63organelle transport along microtubule (GO:0072384)3.23109733
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.22018255
65neurotransmitter transport (GO:0006836)3.21483626
66regulation of cAMP-dependent protein kinase activity (GO:2000479)3.21338611
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.20533841
68adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.19306558
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18337117
70mechanosensory behavior (GO:0007638)3.18026985
71innervation (GO:0060384)3.16703411
72positive regulation of neurotransmitter secretion (GO:0001956)3.16383626
73synapse assembly (GO:0007416)3.16292018
74negative regulation of microtubule polymerization (GO:0031115)3.13402166
75regulation of neurotransmitter secretion (GO:0046928)3.12303307
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.11259059
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09849408
78auditory behavior (GO:0031223)3.09841975
79intraspecies interaction between organisms (GO:0051703)3.08230038
80social behavior (GO:0035176)3.08230038
81long-term synaptic potentiation (GO:0060291)3.08225671
82neuronal action potential (GO:0019228)3.07298251
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06657232
84glycosphingolipid biosynthetic process (GO:0006688)3.05745987
85short-term memory (GO:0007614)3.05538607
86behavioral fear response (GO:0001662)3.04120878
87behavioral defense response (GO:0002209)3.04120878
88positive regulation of synapse assembly (GO:0051965)3.03577089
89dopamine receptor signaling pathway (GO:0007212)3.03536594
90neuromuscular synaptic transmission (GO:0007274)3.02391993
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02340656
92prepulse inhibition (GO:0060134)3.00354827
93membrane hyperpolarization (GO:0060081)2.99908614
94presynaptic membrane organization (GO:0097090)2.99656358
95membrane depolarization (GO:0051899)2.99487020
96cellular potassium ion homeostasis (GO:0030007)2.98601922
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97938827
98nucleobase catabolic process (GO:0046113)2.97855070
99positive regulation of neurotransmitter transport (GO:0051590)2.96724404
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96380111
101neuromuscular process controlling balance (GO:0050885)2.96002935
102dendritic spine organization (GO:0097061)2.95987287
103behavioral response to ethanol (GO:0048149)2.95873225
104regulation of calcium ion-dependent exocytosis (GO:0017158)2.94952497
105response to auditory stimulus (GO:0010996)2.94579319
106startle response (GO:0001964)2.94401412
107regulation of dendritic spine development (GO:0060998)2.92640538
108regulation of neurotransmitter levels (GO:0001505)2.92341300
109positive regulation of dendritic spine development (GO:0060999)2.91471335
110cerebellum development (GO:0021549)2.89990013
111fear response (GO:0042596)2.89665479
112C4-dicarboxylate transport (GO:0015740)2.89588196
113learning (GO:0007612)2.88822946
114adult walking behavior (GO:0007628)2.88526579
115positive regulation of mitochondrial fission (GO:0090141)2.88128279
116regulation of neurotransmitter transport (GO:0051588)2.87460284
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87348954
118synapse organization (GO:0050808)2.86031667
119negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85401849
120regulation of feeding behavior (GO:0060259)2.77038098
121mitochondrion transport along microtubule (GO:0047497)2.76399870
122establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.76399870
123synaptic transmission (GO:0007268)2.71436214
124adult behavior (GO:0030534)2.67497918
125retinal cone cell development (GO:0046549)2.66529427
126serotonin metabolic process (GO:0042428)2.65447898
127regulation of synaptic transmission, GABAergic (GO:0032228)2.61464991
128regulation of synapse maturation (GO:0090128)2.59834303
129neuronal ion channel clustering (GO:0045161)2.57956035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.42457862
2GBX2_23144817_ChIP-Seq_PC3_Human3.56230606
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88165344
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83636438
5REST_21632747_ChIP-Seq_MESCs_Mouse2.80024081
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71576825
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.49337187
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44668480
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44668480
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.39154840
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36147479
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34443957
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33529908
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31648879
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26735982
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.17870832
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16378313
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14779932
19DROSHA_22980978_ChIP-Seq_HELA_Human2.14655637
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13664245
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09926836
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.07730973
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.06544775
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05645065
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05519125
26TAF15_26573619_Chip-Seq_HEK293_Human2.02570153
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97966872
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92156081
29AR_21572438_ChIP-Seq_LNCaP_Human1.88926798
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.87974330
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78674800
32SMAD4_21799915_ChIP-Seq_A2780_Human1.72525097
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68700150
34IGF1R_20145208_ChIP-Seq_DFB_Human1.64847564
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60781206
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60512112
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59343314
38ZNF274_21170338_ChIP-Seq_K562_Hela1.55603796
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54699145
40* P300_19829295_ChIP-Seq_ESCs_Human1.50599205
41RNF2_27304074_Chip-Seq_NSC_Mouse1.42893133
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42886384
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42186458
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.40893022
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39732253
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39148872
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38892450
48* STAT3_23295773_ChIP-Seq_U87_Human1.38886914
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37937619
50* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37012864
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.36550711
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.35501132
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34944971
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34385292
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.33034853
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31442743
57AR_25329375_ChIP-Seq_VCAP_Human1.30090892
58FUS_26573619_Chip-Seq_HEK293_Human1.28716699
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.26906614
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26772987
61EWS_26573619_Chip-Seq_HEK293_Human1.26706236
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24188330
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23986654
64* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23793822
65* CBP_20019798_ChIP-Seq_JUKART_Human1.23793822
66AR_19668381_ChIP-Seq_PC3_Human1.23292701
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.22677414
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.21811229
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20363608
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20123827
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17791432
72TCF4_23295773_ChIP-Seq_U87_Human1.17621352
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16461069
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16373623
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.15903202
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.15884189
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14952290
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14952290
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14154669
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13651410
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13005981
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.12646070
83AHR_22903824_ChIP-Seq_MCF-7_Human1.12178616
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.10749817
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10160414
86RUNX2_22187159_ChIP-Seq_PCA_Human1.09751098
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09435778
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08383588
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07710660
90SMAD3_21741376_ChIP-Seq_ESCs_Human1.07236387
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07029955
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.04675760
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04522326
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.04425604
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03942937
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03598118
97* TAL1_26923725_Chip-Seq_HPCs_Mouse1.03024093
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02968157
99RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02868779
100VDR_22108803_ChIP-Seq_LS180_Human1.00984807
101KDM2B_26808549_Chip-Seq_K562_Human1.00835831
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00807921
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00759707
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00106356
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99951855
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99926077
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99649980
108* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98431481
109SMAD4_21741376_ChIP-Seq_EPCs_Human0.98058503
110TCF4_22108803_ChIP-Seq_LS180_Human0.97833723
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97714215
112TP53_22573176_ChIP-Seq_HFKS_Human0.97141444
113KDM2B_26808549_Chip-Seq_REH_Human0.96647533
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96061923
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.94873935
116ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93810422
117BCAT_22108803_ChIP-Seq_LS180_Human0.91369271
118* JUN_21703547_ChIP-Seq_K562_Human0.91019940
119* ER_23166858_ChIP-Seq_MCF-7_Human0.90472664
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90319404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.90225214
2MP0003880_abnormal_central_pattern4.64243889
3MP0004270_analgesia4.11941083
4MP0003635_abnormal_synaptic_transmissio4.03366504
5MP0002063_abnormal_learning/memory/cond3.30373428
6MP0009745_abnormal_behavioral_response3.12762318
7MP0002734_abnormal_mechanical_nocicepti2.79542169
8MP0005423_abnormal_somatic_nervous2.78229648
9MP0002064_seizures2.77722752
10MP0001968_abnormal_touch/_nociception2.77219405
11MP0002572_abnormal_emotion/affect_behav2.76579459
12MP0009046_muscle_twitch2.48258051
13MP0001486_abnormal_startle_reflex2.43707295
14MP0000778_abnormal_nervous_system2.32281781
15MP0002272_abnormal_nervous_system2.30998521
16MP0002822_catalepsy2.25970859
17MP0002733_abnormal_thermal_nociception2.21833799
18MP0001440_abnormal_grooming_behavior2.20977463
19MP0002735_abnormal_chemical_nociception2.20102473
20MP0009780_abnormal_chondrocyte_physiolo2.18768247
21MP0002184_abnormal_innervation2.10678093
22MP0006276_abnormal_autonomic_nervous2.07106259
23MP0001501_abnormal_sleep_pattern2.05622616
24MP0001970_abnormal_pain_threshold2.00976716
25MP0003787_abnormal_imprinting2.00622290
26MP0002557_abnormal_social/conspecific_i1.93859067
27MP0004924_abnormal_behavior1.93501491
28MP0005386_behavior/neurological_phenoty1.93501491
29MP0002909_abnormal_adrenal_gland1.92916369
30MP0002736_abnormal_nociception_after1.91803029
31MP0002067_abnormal_sensory_capabilities1.91643693
32MP0001984_abnormal_olfaction1.85070586
33MP0004811_abnormal_neuron_physiology1.82727459
34MP0001529_abnormal_vocalization1.77314813
35MP0005645_abnormal_hypothalamus_physiol1.72656827
36MP0000955_abnormal_spinal_cord1.68792401
37MP0003329_amyloid_beta_deposits1.64668798
38MP0000569_abnormal_digit_pigmentation1.58198860
39MP0008569_lethality_at_weaning1.55130372
40MP0003879_abnormal_hair_cell1.54936129
41MP0001188_hyperpigmentation1.53282253
42MP0003195_calcinosis1.50415066
43MP0002882_abnormal_neuron_morphology1.49753500
44MP0004858_abnormal_nervous_system1.49324097
45MP0005646_abnormal_pituitary_gland1.45391972
46MP0004885_abnormal_endolymph1.39721434
47MP0002066_abnormal_motor_capabilities/c1.38868330
48MP0003122_maternal_imprinting1.33726098
49MP0001905_abnormal_dopamine_level1.32964737
50MP0001502_abnormal_circadian_rhythm1.31688717
51MP0002152_abnormal_brain_morphology1.29362677
52MP0005499_abnormal_olfactory_system1.27855396
53MP0005394_taste/olfaction_phenotype1.27855396
54MP0010386_abnormal_urinary_bladder1.16928061
55MP0000631_abnormal_neuroendocrine_gland1.11792367
56MP0005187_abnormal_penis_morphology1.03973466
57MP0008877_abnormal_DNA_methylation1.03706900
58MP0003633_abnormal_nervous_system1.01265592
59MP0004742_abnormal_vestibular_system0.97961246
60MP0001986_abnormal_taste_sensitivity0.97260298
61MP0010234_abnormal_vibrissa_follicle0.97214547
62MP0002229_neurodegeneration0.96803595
63MP0003121_genomic_imprinting0.95132828
64MP0005253_abnormal_eye_physiology0.94856815
65MP0002069_abnormal_eating/drinking_beha0.94151664
66MP0003631_nervous_system_phenotype0.94009637
67MP0008961_abnormal_basal_metabolism0.93625762
68MP0000013_abnormal_adipose_tissue0.92068208
69MP0004142_abnormal_muscle_tone0.91775322
70MP0003861_abnormal_nervous_system0.89703231
71MP0002928_abnormal_bile_duct0.86259720
72MP0002160_abnormal_reproductive_system0.85624874
73MP0004043_abnormal_pH_regulation0.85557649
74MP0002752_abnormal_somatic_nervous0.84728166
75MP0008789_abnormal_olfactory_epithelium0.82798804
76MP0006072_abnormal_retinal_apoptosis0.80896868
77MP0004147_increased_porphyrin_level0.78449163
78MP0001963_abnormal_hearing_physiology0.77958302
79MP0004133_heterotaxia0.77744595
80MP0002837_dystrophic_cardiac_calcinosis0.76528029
81MP0003634_abnormal_glial_cell0.76042938
82MP0002638_abnormal_pupillary_reflex0.75276367
83MP0004085_abnormal_heartbeat0.74950860
84MP0001485_abnormal_pinna_reflex0.74739381
85MP0008872_abnormal_physiological_respon0.74525919
86MP0005551_abnormal_eye_electrophysiolog0.74274872
87MP0008875_abnormal_xenobiotic_pharmacok0.73747460
88MP0004145_abnormal_muscle_electrophysio0.73584525
89MP0003632_abnormal_nervous_system0.72485459
90MP0002234_abnormal_pharynx_morphology0.72451588
91MP0000427_abnormal_hair_cycle0.72133711
92MP0000026_abnormal_inner_ear0.71752536
93MP0003698_abnormal_male_reproductive0.70705622
94MP0001664_abnormal_digestion0.70215043
95MP0002102_abnormal_ear_morphology0.69784077
96MP0003123_paternal_imprinting0.69567078
97MP0000566_synostosis0.68641677
98MP0002876_abnormal_thyroid_physiology0.67447035
99MP0005195_abnormal_posterior_eye0.66037389
100MP0005535_abnormal_body_temperature0.65014609
101MP0001177_atelectasis0.64423536
102MP0005084_abnormal_gallbladder_morpholo0.63927660
103MP0004215_abnormal_myocardial_fiber0.63346650
104MP0003137_abnormal_impulse_conducting0.63227383
105MP0008874_decreased_physiological_sensi0.62918984
106MP0003938_abnormal_ear_development0.60878775
107MP0001299_abnormal_eye_distance/0.60273871
108MP0004233_abnormal_muscle_weight0.59240714
109MP0000604_amyloidosis0.58664862
110MP0001943_abnormal_respiration0.58366575
111MP0004510_myositis0.55203845
112MP0001348_abnormal_lacrimal_gland0.54620614
113MP0010769_abnormal_survival0.54421143
114MP0010770_preweaning_lethality0.54420757
115MP0002082_postnatal_lethality0.54420757
116MP0003956_abnormal_body_size0.53072221
117MP0002751_abnormal_autonomic_nervous0.52437449
118MP0003890_abnormal_embryonic-extraembry0.51742838
119MP0010768_mortality/aging0.51637969

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.36220973
2Myokymia (HP:0002411)5.59780743
3Focal seizures (HP:0007359)5.24360841
4Visual hallucinations (HP:0002367)5.01017254
5Atonic seizures (HP:0010819)4.32788197
6Epileptic encephalopathy (HP:0200134)4.20208499
7Absence seizures (HP:0002121)3.85576511
8Progressive cerebellar ataxia (HP:0002073)3.73903235
9Febrile seizures (HP:0002373)3.67641818
10Broad-based gait (HP:0002136)3.56468300
11Generalized tonic-clonic seizures (HP:0002069)3.46417374
12Mutism (HP:0002300)3.45052146
13Dialeptic seizures (HP:0011146)3.43862140
14Supranuclear gaze palsy (HP:0000605)3.39331272
15Ankle clonus (HP:0011448)3.39051899
16Amyotrophic lateral sclerosis (HP:0007354)3.36038249
17Papilledema (HP:0001085)3.35876205
18Drooling (HP:0002307)3.28845890
19Excessive salivation (HP:0003781)3.28845890
20Poor eye contact (HP:0000817)3.11538791
21Urinary bladder sphincter dysfunction (HP:0002839)3.04838757
22Impaired vibration sensation in the lower limbs (HP:0002166)3.04775198
23Abnormality of the corticospinal tract (HP:0002492)3.04681676
24Termporal pattern (HP:0011008)3.04446181
25Insidious onset (HP:0003587)3.04446181
26Amblyopia (HP:0000646)3.04180746
27Truncal ataxia (HP:0002078)3.03859544
28Hyperventilation (HP:0002883)3.03153557
29Urinary urgency (HP:0000012)3.02335097
30Limb dystonia (HP:0002451)2.98528289
31Action tremor (HP:0002345)2.93242284
32Genetic anticipation (HP:0003743)2.88416038
33Cerebral inclusion bodies (HP:0100314)2.87995711
34Epileptiform EEG discharges (HP:0011182)2.80129370
35Abnormality of the labia minora (HP:0012880)2.79979176
36Agitation (HP:0000713)2.75047554
37EEG with generalized epileptiform discharges (HP:0011198)2.74220565
38Type II lissencephaly (HP:0007260)2.72758605
39Depression (HP:0000716)2.70492777
40Abnormal social behavior (HP:0012433)2.69458673
41Impaired social interactions (HP:0000735)2.69458673
42Progressive inability to walk (HP:0002505)2.69333198
43Gaze-evoked nystagmus (HP:0000640)2.68176724
44Inappropriate behavior (HP:0000719)2.67624417
45Impaired smooth pursuit (HP:0007772)2.63713887
46Hypsarrhythmia (HP:0002521)2.63223443
47Anxiety (HP:0000739)2.60186810
48Dysmetria (HP:0001310)2.57888698
49Spastic gait (HP:0002064)2.55052308
50Medial flaring of the eyebrow (HP:0010747)2.52069529
51Abnormal eating behavior (HP:0100738)2.51017682
52Megalencephaly (HP:0001355)2.50537937
53Absent speech (HP:0001344)2.50421843
54Neurofibrillary tangles (HP:0002185)2.49491276
55Status epilepticus (HP:0002133)2.47164808
56Retinal dysplasia (HP:0007973)2.45514017
57Stereotypic behavior (HP:0000733)2.41947288
58Inability to walk (HP:0002540)2.41907482
59Pachygyria (HP:0001302)2.41715317
60Congenital primary aphakia (HP:0007707)2.41508786
61Dysdiadochokinesis (HP:0002075)2.40471661
62Abnormality of the lower motor neuron (HP:0002366)2.33537512
63Abnormality of binocular vision (HP:0011514)2.31600960
64Diplopia (HP:0000651)2.31600960
65Nephrogenic diabetes insipidus (HP:0009806)2.30617648
66Hemiparesis (HP:0001269)2.30197706
67Fetal akinesia sequence (HP:0001989)2.29124381
68Polyphagia (HP:0002591)2.28840572
69Spastic tetraplegia (HP:0002510)2.28219550
70Torticollis (HP:0000473)2.27730867
71Akinesia (HP:0002304)2.26933731
72Protruding tongue (HP:0010808)2.24029180
73Hypothermia (HP:0002045)2.22014447
74Nephronophthisis (HP:0000090)2.21652213
75Postural instability (HP:0002172)2.21248937
76Abnormality of salivation (HP:0100755)2.19988021
77Abnormality of ocular smooth pursuit (HP:0000617)2.17310162
78Apathy (HP:0000741)2.17267052
79Gait imbalance (HP:0002141)2.17025112
80Pheochromocytoma (HP:0002666)2.17024296
81Poor suck (HP:0002033)2.16662324
82Sleep apnea (HP:0010535)2.15423603
83Genital tract atresia (HP:0001827)2.14841621
84Molar tooth sign on MRI (HP:0002419)2.13794875
85Abnormality of midbrain morphology (HP:0002418)2.13794875
86Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13670578
87Degeneration of the lateral corticospinal tracts (HP:0002314)2.13670578
88Papillary thyroid carcinoma (HP:0002895)2.12094828
89Vaginal atresia (HP:0000148)2.10200921
90Bradykinesia (HP:0002067)2.07701591
91Pancreatic cysts (HP:0001737)2.06124634
92Ulnar claw (HP:0001178)2.05563312
93Hypoplasia of the brainstem (HP:0002365)2.04716546
94Aplasia/Hypoplasia of the brainstem (HP:0007362)2.04716546
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02863164
96Focal dystonia (HP:0004373)2.02479363
97Neuroendocrine neoplasm (HP:0100634)2.01515724
98Lower limb muscle weakness (HP:0007340)2.01332316
99Blue irides (HP:0000635)2.01116604
100Generalized myoclonic seizures (HP:0002123)1.98199781
101Scanning speech (HP:0002168)1.98159350
102Sporadic (HP:0003745)1.90857123
103Morphological abnormality of the pyramidal tract (HP:0002062)1.89219872
104Exotropia (HP:0000577)1.88697686
105Diminished motivation (HP:0000745)1.88455682
106Specific learning disability (HP:0001328)1.87360083
107Muscular hypotonia of the trunk (HP:0008936)1.86471275
108Obstructive sleep apnea (HP:0002870)1.85873260
109Craniofacial dystonia (HP:0012179)1.85284285
110Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84793700
111Insomnia (HP:0100785)1.84584380
112Failure to thrive in infancy (HP:0001531)1.82515748
113Impaired vibratory sensation (HP:0002495)1.82253718
114Intention tremor (HP:0002080)1.81553139
115Esotropia (HP:0000565)1.81046569
116True hermaphroditism (HP:0010459)1.80874072
117Aqueductal stenosis (HP:0002410)1.80436505
118Dyskinesia (HP:0100660)1.80150152
119Lissencephaly (HP:0001339)1.80013212
120Pendular nystagmus (HP:0012043)1.78971651
121Pointed chin (HP:0000307)1.78914268
122Oligodactyly (hands) (HP:0001180)1.78897756
123Dysmetric saccades (HP:0000641)1.78741595
124Clonus (HP:0002169)1.78219762
125Abolished electroretinogram (ERG) (HP:0000550)1.77407266
126Poor coordination (HP:0002370)1.76540248
127Hyperthyroidism (HP:0000836)1.76537346
128Gait ataxia (HP:0002066)1.76492015
129CNS hypomyelination (HP:0003429)1.75233859
130Hypoplasia of the corpus callosum (HP:0002079)1.74163239
131Decreased central vision (HP:0007663)1.73618135
132Pancreatic fibrosis (HP:0100732)1.73463797
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.72623482
134Intellectual disability, severe (HP:0010864)1.72564274
135Bony spicule pigmentary retinopathy (HP:0007737)1.72490642
136Prolonged QT interval (HP:0001657)1.72266129
137Paraplegia (HP:0010550)1.72122415
138Abnormality of the renal medulla (HP:0100957)1.68571190
139Atrophy/Degeneration involving motor neurons (HP:0007373)1.65734855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.96195233
2MAP3K94.05067062
3NTRK33.87953722
4EPHA43.45886295
5MAP3K43.25811390
6MAP2K72.60924673
7MINK12.60727453
8NTRK22.27695756
9KSR22.26531925
10KSR12.01414925
11PAK62.01344952
12MAPK131.98381707
13PINK11.97876102
14TRIM281.93492360
15SIK21.90955090
16DAPK21.88363105
17RIPK41.78128937
18MAP2K41.74416288
19MAP3K121.72253412
20LATS21.70617038
21PNCK1.64853335
22PRKD31.64698422
23PLK21.64377192
24CASK1.61093980
25MAP3K21.57006937
26NTRK11.49834811
27ARAF1.49067964
28TNIK1.45068409
29CDK51.44913276
30BMPR21.39619511
31CAMKK11.35983546
32ADRBK21.29045798
33GRK51.26869387
34ERBB31.24896788
35TYRO31.24739985
36UHMK11.19802076
37DAPK11.17350974
38CSNK1G21.17033729
39EPHA31.13466032
40PRPF4B1.12485797
41PHKG11.12322976
42PHKG21.12322976
43MAP4K21.11976043
44RAF11.11763151
45DYRK21.10957298
46TAOK11.08850665
47RET1.07033093
48MAP3K61.02832764
49MAP3K130.95093285
50PRKCG0.94366965
51DYRK1A0.94021709
52CAMK2A0.91165822
53STK380.90910800
54MARK20.86857340
55FES0.86849021
56CDK190.85077276
57CDK140.82969741
58CAMKK20.82792375
59PAK30.82108140
60CDK180.81123390
61STK110.78932863
62CDK150.77804001
63GRK10.76397350
64FGR0.75871217
65CAMK2B0.69280300
66SCYL20.69265381
67SIK30.67459820
68CDK11A0.66507294
69WNK30.65157936
70SGK4940.65121539
71SGK2230.65121539
72EPHB20.65118421
73CSNK1G30.64013252
74PRKCH0.63231332
75STK390.60217148
76CAMK40.59166697
77ADRBK10.57069995
78SGK10.56830043
79LMTK20.55872721
80WNK40.55751721
81PRKCZ0.53591319
82CSNK1D0.52920449
83GRK70.52362568
84SGK20.51678181
85STK38L0.51386574
86TAOK30.51328618
87CSNK1A1L0.51130578
88ALK0.50444204
89PRKACA0.50008146
90PTK2B0.49476059
91CAMK2D0.48639559
92LIMK10.48320131
93CAMK2G0.46180175
94CAMK10.45416580
95BCR0.44940997
96MAP3K10.44792384
97CSNK1E0.44261615
98MAPK120.44156454
99RPS6KA20.44027288
100PRKG10.43678680
101MAPK100.42999691
102DMPK0.42045876
103PRKCI0.41923976
104DYRK30.40122590
105PRKAA10.40103937
106PRKCE0.39945897
107RPS6KA30.39903951
108MAP2K10.39618217
109PRKACB0.39169751
110BCKDK0.38584394
111CSNK1A10.37821602
112CSNK1G10.37502725
113BRAF0.36859841
114CAMK1G0.36852246
115PDK10.36599944
116FYN0.36221014
117RIPK10.35482125
118SGK30.35133048
119CDK30.34450650
120DYRK1B0.34449545
121PRKCA0.33941137
122CDC42BPA0.33211215
123TSSK60.32747608
124CCNB10.32600325
125NME10.32390160
126FRK0.32241839
127INSRR0.31896259
128PDPK10.31297567
129BMPR1B0.31075002
130MAP2K60.29567117
131FGFR20.28622742
132PRKCB0.28577844
133MAPK90.27316749
134OXSR10.26481354
135PKN10.26138578

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.38306912
2Synaptic vesicle cycle_Homo sapiens_hsa047212.90814025
3Long-term potentiation_Homo sapiens_hsa047202.73618577
4Olfactory transduction_Homo sapiens_hsa047402.65673110
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56508132
6Circadian entrainment_Homo sapiens_hsa047132.53796712
7Glutamatergic synapse_Homo sapiens_hsa047242.47490649
8GABAergic synapse_Homo sapiens_hsa047272.45749652
9Amphetamine addiction_Homo sapiens_hsa050312.44577070
10Dopaminergic synapse_Homo sapiens_hsa047282.35669615
11Morphine addiction_Homo sapiens_hsa050322.34497971
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10327830
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07001854
14Insulin secretion_Homo sapiens_hsa049112.05360489
15Cholinergic synapse_Homo sapiens_hsa047252.01456770
16Salivary secretion_Homo sapiens_hsa049701.91340468
17Serotonergic synapse_Homo sapiens_hsa047261.83041720
18Taste transduction_Homo sapiens_hsa047421.81483488
19Long-term depression_Homo sapiens_hsa047301.79381499
20Cocaine addiction_Homo sapiens_hsa050301.72953579
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71081902
22Renin secretion_Homo sapiens_hsa049241.71044566
23Gastric acid secretion_Homo sapiens_hsa049711.67642776
24Butanoate metabolism_Homo sapiens_hsa006501.67031244
25Oxytocin signaling pathway_Homo sapiens_hsa049211.59989532
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54480601
27GnRH signaling pathway_Homo sapiens_hsa049121.54220559
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53289678
29Gap junction_Homo sapiens_hsa045401.42704744
30Axon guidance_Homo sapiens_hsa043601.39438174
31Type II diabetes mellitus_Homo sapiens_hsa049301.33548037
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30143873
33Collecting duct acid secretion_Homo sapiens_hsa049661.29553607
34Calcium signaling pathway_Homo sapiens_hsa040201.29027364
35Estrogen signaling pathway_Homo sapiens_hsa049151.28399760
36Oxidative phosphorylation_Homo sapiens_hsa001901.27745834
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22230389
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19049041
39cAMP signaling pathway_Homo sapiens_hsa040241.18733746
40Glioma_Homo sapiens_hsa052141.16396663
41Parkinsons disease_Homo sapiens_hsa050121.16369134
42Oocyte meiosis_Homo sapiens_hsa041141.16259462
43ErbB signaling pathway_Homo sapiens_hsa040121.14586110
44Dorso-ventral axis formation_Homo sapiens_hsa043201.12147316
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08200279
46Melanogenesis_Homo sapiens_hsa049161.08095999
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01127602
48Caffeine metabolism_Homo sapiens_hsa002321.00343768
49Linoleic acid metabolism_Homo sapiens_hsa005910.97761191
50Vibrio cholerae infection_Homo sapiens_hsa051100.97509327
51Phototransduction_Homo sapiens_hsa047440.96123514
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96029901
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94525516
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92779499
55VEGF signaling pathway_Homo sapiens_hsa043700.92527892
56Endometrial cancer_Homo sapiens_hsa052130.90523839
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.89106230
58Choline metabolism in cancer_Homo sapiens_hsa052310.89105912
59Regulation of autophagy_Homo sapiens_hsa041400.88784785
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87652536
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.85059878
62Bile secretion_Homo sapiens_hsa049760.84369539
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84194482
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.84029197
65Pancreatic secretion_Homo sapiens_hsa049720.83751146
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.83006954
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81935064
68MAPK signaling pathway_Homo sapiens_hsa040100.80674689
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80608625
70Retinol metabolism_Homo sapiens_hsa008300.80249563
71Colorectal cancer_Homo sapiens_hsa052100.79533408
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.79084782
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.79060304
74Renal cell carcinoma_Homo sapiens_hsa052110.78411398
75Tryptophan metabolism_Homo sapiens_hsa003800.77355236
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76264917
77Thyroid hormone synthesis_Homo sapiens_hsa049180.75691673
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75091904
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74541111
80Ras signaling pathway_Homo sapiens_hsa040140.73864972
81mTOR signaling pathway_Homo sapiens_hsa041500.73711886
82Ether lipid metabolism_Homo sapiens_hsa005650.72687391
83Alcoholism_Homo sapiens_hsa050340.72616311
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70824956
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70525794
86Cardiac muscle contraction_Homo sapiens_hsa042600.69992749
87Peroxisome_Homo sapiens_hsa041460.69234041
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67772966
89Glucagon signaling pathway_Homo sapiens_hsa049220.67389301
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65805414
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.65269929
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64894304
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64470216
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64456295
95Chemical carcinogenesis_Homo sapiens_hsa052040.64075130
96Propanoate metabolism_Homo sapiens_hsa006400.63841386
97Wnt signaling pathway_Homo sapiens_hsa043100.63787345
98Non-small cell lung cancer_Homo sapiens_hsa052230.61672127
99Circadian rhythm_Homo sapiens_hsa047100.59901805
100Steroid biosynthesis_Homo sapiens_hsa001000.59400194
101Protein export_Homo sapiens_hsa030600.58939847
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58763873
103Huntingtons disease_Homo sapiens_hsa050160.58638111
104Nitrogen metabolism_Homo sapiens_hsa009100.58017995
105Basal transcription factors_Homo sapiens_hsa030220.57662419
106Rap1 signaling pathway_Homo sapiens_hsa040150.56501707
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56071050
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55500420
109Histidine metabolism_Homo sapiens_hsa003400.55013785
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54806292
111Phenylalanine metabolism_Homo sapiens_hsa003600.54313220
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53652456
113Inositol phosphate metabolism_Homo sapiens_hsa005620.53440730
114Arginine biosynthesis_Homo sapiens_hsa002200.52874516
115Prolactin signaling pathway_Homo sapiens_hsa049170.52639105
116Insulin signaling pathway_Homo sapiens_hsa049100.51960699
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49122580
118Type I diabetes mellitus_Homo sapiens_hsa049400.48814961
119beta-Alanine metabolism_Homo sapiens_hsa004100.48498086
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47232160
121T cell receptor signaling pathway_Homo sapiens_hsa046600.46173847
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44731780
123Ovarian steroidogenesis_Homo sapiens_hsa049130.44705559
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43720558
125Vitamin B6 metabolism_Homo sapiens_hsa007500.43638907
126Endocytosis_Homo sapiens_hsa041440.43107921
127Dilated cardiomyopathy_Homo sapiens_hsa054140.43095896
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42690151
129Chemokine signaling pathway_Homo sapiens_hsa040620.42378347
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42218084
131Prion diseases_Homo sapiens_hsa050200.41609377
132Pancreatic cancer_Homo sapiens_hsa052120.40969101
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39409447
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37913762
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37728210
136Alzheimers disease_Homo sapiens_hsa050100.37477764
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37413309
138ABC transporters_Homo sapiens_hsa020100.36507957
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33961191
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33420755
141Tight junction_Homo sapiens_hsa045300.30507562
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29966048
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28866069

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