RUNX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67011152
2positive regulation of gamma-delta T cell activation (GO:0046645)4.55117411
3positive regulation of B cell differentiation (GO:0045579)3.90559390
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.67273019
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.67273019
6positive regulation by organism of defense response of other organism involved in symbiotic interact3.67273019
7modulation by symbiont of host immune response (GO:0052553)3.67273019
8positive regulation by symbiont of host defense response (GO:0052509)3.67273019
9modulation by symbiont of host defense response (GO:0052031)3.67273019
10negative regulation of phagocytosis (GO:0050765)3.61331937
11neutrophil activation involved in immune response (GO:0002283)3.49962742
12regulation of B cell differentiation (GO:0045577)3.47470408
13* definitive hemopoiesis (GO:0060216)3.45631070
14regulation of B cell receptor signaling pathway (GO:0050855)3.38311613
15regulation of interferon-beta biosynthetic process (GO:0045357)3.29665221
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27391351
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.27391351
18response to muramyl dipeptide (GO:0032495)3.26749604
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22872420
20regulation of interleukin-12 biosynthetic process (GO:0045075)3.19189605
21immunoglobulin mediated immune response (GO:0016064)3.19039143
22regulation of gamma-delta T cell differentiation (GO:0045586)3.17845137
23hypotonic response (GO:0006971)3.17231664
24regulation of gamma-delta T cell activation (GO:0046643)3.16937674
25regulation of vitamin D biosynthetic process (GO:0060556)3.14574730
26response to protozoan (GO:0001562)3.12089634
27antigen processing and presentation of endogenous antigen (GO:0019883)3.08150786
28pinocytosis (GO:0006907)3.03466606
29leukocyte aggregation (GO:0070486)3.01298581
30positive regulation of macrophage differentiation (GO:0045651)2.99488037
31megakaryocyte development (GO:0035855)2.95479626
32cellular response to exogenous dsRNA (GO:0071360)2.95221059
33B cell receptor signaling pathway (GO:0050853)2.94957873
34response to peptidoglycan (GO:0032494)2.94863208
35embryonic process involved in female pregnancy (GO:0060136)2.93580900
36hepatocyte apoptotic process (GO:0097284)2.92547362
37negative regulation of interleukin-8 production (GO:0032717)2.90759303
38ribosomal small subunit assembly (GO:0000028)2.90139983
39germinal center formation (GO:0002467)2.90059102
40neutrophil activation (GO:0042119)2.86894902
41mannose metabolic process (GO:0006013)2.85839931
42positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.83404897
43myeloid dendritic cell activation (GO:0001773)2.82694013
44regulation of T-helper 1 cell differentiation (GO:0045625)2.82472680
45tolerance induction (GO:0002507)2.81482424
46mast cell activation (GO:0045576)2.79928086
47lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79200962
48macrophage activation involved in immune response (GO:0002281)2.78637149
49defense response to protozoan (GO:0042832)2.76561966
50T cell homeostasis (GO:0043029)2.76380457
51Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75044633
52antigen processing and presentation via MHC class Ib (GO:0002475)2.72998005
53angiogenesis involved in wound healing (GO:0060055)2.72683735
54B cell homeostasis (GO:0001782)2.72149515
55myeloid cell activation involved in immune response (GO:0002275)2.68568130
56negative regulation of erythrocyte differentiation (GO:0045647)2.66413702
57negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.65206489
58tyrosine phosphorylation of STAT protein (GO:0007260)2.63822710
59negative regulation of T-helper cell differentiation (GO:0045623)2.62894987
60negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.62894987
61neutrophil mediated immunity (GO:0002446)2.62510397
62positive regulation of vasculogenesis (GO:2001214)2.61883774
63granulocyte activation (GO:0036230)2.61808497
64regulation of platelet aggregation (GO:0090330)2.60195695
65lymphocyte homeostasis (GO:0002260)2.60106716
66regulation of mast cell degranulation (GO:0043304)2.60071343
67production of molecular mediator involved in inflammatory response (GO:0002532)2.59485837
68regulation of macrophage cytokine production (GO:0010935)2.59046731
69positive regulation of interferon-alpha production (GO:0032727)2.58943873
70negative thymic T cell selection (GO:0045060)2.58116009
71negative regulation of interleukin-12 production (GO:0032695)2.58060037
72regulation of integrin activation (GO:0033623)2.57531024
73positive thymic T cell selection (GO:0045059)2.56468097
74regulation of leukocyte degranulation (GO:0043300)2.56015029
75positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.55798288
76negative regulation of interleukin-6 production (GO:0032715)2.53485593
77positive regulation of tolerance induction (GO:0002645)2.53082792
78regulation of necroptotic process (GO:0060544)2.53080877
79regulation of interferon-alpha production (GO:0032647)2.52999196
80response to laminar fluid shear stress (GO:0034616)2.52485071
81detection of molecule of bacterial origin (GO:0032490)2.51958321
82respiratory burst (GO:0045730)2.51951021
83regulation of tolerance induction (GO:0002643)2.51305548
84JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.50920443
85mature B cell differentiation involved in immune response (GO:0002313)2.50681466
86regulation of erythrocyte differentiation (GO:0045646)2.50577629
87response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.50398677
88response to host (GO:0075136)2.50398677
89response to host defenses (GO:0052200)2.50398677
90regulation of mast cell activation (GO:0033003)2.50236092
91negative regulation of cell killing (GO:0031342)2.48348812
92negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.48348812
93response to host immune response (GO:0052572)2.47306667
94response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.47306667
95regulation of mast cell activation involved in immune response (GO:0033006)2.47041051
96B cell mediated immunity (GO:0019724)2.46907547
97mature B cell differentiation (GO:0002335)2.46827575
98positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.46767108
99regulation of myeloid leukocyte mediated immunity (GO:0002886)2.46425447
100interferon-gamma production (GO:0032609)2.46266971
101mucosal-associated lymphoid tissue development (GO:0048537)2.45202691
102Peyers patch development (GO:0048541)2.45202691
103positive regulation of natural killer cell differentiation (GO:0032825)2.44975874
104negative T cell selection (GO:0043383)2.44595172
105regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.44183574
106positive regulation of B cell activation (GO:0050871)2.44158774
107negative regulation of T cell mediated immunity (GO:0002710)2.44027871
108thrombin receptor signaling pathway (GO:0070493)2.43423429
109regulation of vitamin metabolic process (GO:0030656)2.42314230
110response to type I interferon (GO:0034340)2.42298865
111CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.41194622
112interferon-gamma-mediated signaling pathway (GO:0060333)2.40936112
113negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.40331711
114membrane raft organization (GO:0031579)2.40264229
115response to interferon-alpha (GO:0035455)2.40110073
116establishment of endothelial barrier (GO:0061028)2.39733620
117cellular response to thyroid hormone stimulus (GO:0097067)2.39589799
118negative regulation of cytokine production involved in immune response (GO:0002719)2.39225191
119negative regulation of B cell proliferation (GO:0030889)2.39200792
120cellular extravasation (GO:0045123)2.39064994
121positive regulation of mast cell degranulation (GO:0043306)2.38809818
122positive regulation of mast cell activation involved in immune response (GO:0033008)2.38809818
123lymph node development (GO:0048535)2.38411790
124myeloid dendritic cell differentiation (GO:0043011)2.38375347
125regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.37543302
126positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.37455341
127cellular response to ethanol (GO:0071361)2.37144951
128negative regulation of nitric oxide biosynthetic process (GO:0045019)2.36844334
129type I interferon signaling pathway (GO:0060337)2.36597284
130cellular response to type I interferon (GO:0071357)2.36597284
131NIK/NF-kappaB signaling (GO:0038061)2.36520727
132myeloid leukocyte activation (GO:0002274)2.35825426
133regulation of T-helper 2 cell differentiation (GO:0045628)2.35721008
134positive regulation of T-helper cell differentiation (GO:0045624)2.35088293
135positive regulation of natural killer cell activation (GO:0032816)2.34518375
136leukocyte homeostasis (GO:0001776)2.34398572
137positive regulation of isotype switching (GO:0045830)2.33790327
138skin morphogenesis (GO:0043589)2.33362249
139regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.32860989
140positive regulation of protein import into nucleus, translocation (GO:0033160)2.32621670
141positive regulation of mast cell activation (GO:0033005)2.32118418
142germ cell migration (GO:0008354)2.31786954
143positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.31707568
144positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.31216032
145positive regulation of alpha-beta T cell differentiation (GO:0046638)2.31200994
146regulation of dendritic cell antigen processing and presentation (GO:0002604)2.30238776
147positive regulation of tumor necrosis factor production (GO:0032760)2.29744359
148regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.27287417
149nerve growth factor signaling pathway (GO:0038180)2.27269434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.88479664
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.61595947
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.52534665
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.43456768
5* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.98969978
6* IRF8_22096565_ChIP-ChIP_GC-B_Human3.87692849
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44186679
8* SCL_19346495_ChIP-Seq_HPC-7_Human3.42772348
9* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.09495455
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.07382357
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.99340207
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76369496
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75033792
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.74893816
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.72653673
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71089964
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44754853
18MYC_22102868_ChIP-Seq_BL_Human2.41853831
19* VDR_21846776_ChIP-Seq_THP-1_Human2.34606595
20* MYB_26560356_Chip-Seq_TH2_Human2.30276070
21* RUNX_20019798_ChIP-Seq_JUKART_Human2.23615312
22* VDR_24763502_ChIP-Seq_THP-1_Human2.19673181
23* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.16710670
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14861961
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.14854210
26* SPI1_23547873_ChIP-Seq_NB4_Human2.14723201
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10773437
28TP63_17297297_ChIP-ChIP_HaCaT_Human2.10190632
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.09054372
30* RUNX1_22412390_ChIP-Seq_EML_Mouse2.05499625
31* MAF_26560356_Chip-Seq_TH1_Human2.05109827
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05068037
33* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.00221430
34MYB_26560356_Chip-Seq_TH1_Human1.99080593
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98499396
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.94984616
37* TCF7_22412390_ChIP-Seq_EML_Mouse1.92731600
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89451407
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.89162847
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88884499
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84084545
42UTX_26944678_Chip-Seq_JUKART_Human1.69179770
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66162502
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64137871
45GATA1_22025678_ChIP-Seq_K562_Human1.60535608
46* SPI1_23127762_ChIP-Seq_K562_Human1.59035704
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57262095
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56602893
49PU_27001747_Chip-Seq_BMDM_Mouse1.55905445
50* GATA1_19941826_ChIP-Seq_K562_Human1.50527627
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49679188
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49129473
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41047042
54* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37005455
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36568583
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.34152852
57* GATA2_21666600_ChIP-Seq_HMVEC_Human1.33489949
58* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31062490
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30703112
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30452993
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30087006
62* BRD4_25478319_ChIP-Seq_HGPS_Human1.29830051
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.27320456
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26911174
65* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25628043
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24883863
67* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24716577
68* GATA2_19941826_ChIP-Seq_K562_Human1.21986856
69* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21789912
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20705298
71* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19515806
72* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19515806
73* GATA3_27048872_Chip-Seq_THYMUS_Human1.19376305
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18847543
75* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17987025
76VDR_24787735_ChIP-Seq_THP-1_Human1.17792653
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17588158
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16236045
79* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12925025
80* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10886968
81MAF_26560356_Chip-Seq_TH2_Human1.10485232
82* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10420738
83* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09222399
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09040298
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08990158
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08456921
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07852324
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.07764936
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04740120
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03242315
91* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01764067
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01528931
93* KDM2B_26808549_Chip-Seq_JURKAT_Human1.01453802
94UBF1/2_26484160_Chip-Seq_HMECs_Human1.01147460
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00180526
96KDM2B_26808549_Chip-Seq_DND41_Human1.00106240
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00010859
98* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00009989
99ELK1_19687146_ChIP-ChIP_HELA_Human0.99625220
100* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98927780
101ESR1_21235772_ChIP-Seq_MCF-7_Human0.98280549
102* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97591044
103* CJUN_26792858_Chip-Seq_BT549_Human0.96785126
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96238874
105P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95270563
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94679284
107GATA3_26560356_Chip-Seq_TH2_Human0.93433522
108* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92970275
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92435625
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92157583
111* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92123359
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91717970
113E2F1_21310950_ChIP-Seq_MCF-7_Human0.91086754
114RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90548160
115* GATA1_19941827_ChIP-Seq_MEL_Mouse0.89707328
116SMAD_19615063_ChIP-ChIP_OVARY_Human0.89438721
117* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88186969
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85055149
119* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84086042
120* NCOR1_26117541_ChIP-Seq_K562_Human0.83564554
121CIITA_25753668_ChIP-Seq_RAJI_Human0.81673355
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79516643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.15959229
2* MP0002396_abnormal_hematopoietic_system2.67733300
3MP0003436_decreased_susceptibility_to2.61952166
4MP0009278_abnormal_bone_marrow2.41411973
5MP0001545_abnormal_hematopoietic_system2.40497206
6MP0005397_hematopoietic_system_phenotyp2.40497206
7MP0003300_gastrointestinal_ulcer2.31482130
8* MP0004808_abnormal_hematopoietic_stem2.30741387
9MP0001800_abnormal_humoral_immune2.29280628
10MP0002419_abnormal_innate_immunity2.28962303
11MP0002452_abnormal_antigen_presenting2.25759477
12MP0002148_abnormal_hypersensitivity_rea2.24347720
13MP0005000_abnormal_immune_tolerance2.24260312
14MP0000685_abnormal_immune_system2.24213190
15MP0005671_abnormal_response_to2.22078688
16MP0005387_immune_system_phenotype2.21929758
17MP0001790_abnormal_immune_system2.21929758
18MP0005464_abnormal_platelet_physiology2.20700144
19MP0009785_altered_susceptibility_to2.14397907
20MP0002723_abnormal_immune_serum2.05474531
21MP0000569_abnormal_digit_pigmentation2.05328640
22MP0003303_peritoneal_inflammation2.05007663
23MP0002166_altered_tumor_susceptibility2.04542473
24MP0005025_abnormal_response_to2.04291640
25* MP0002420_abnormal_adaptive_immunity2.03631043
26* MP0001819_abnormal_immune_cell2.01402633
27MP0003724_increased_susceptibility_to1.99375898
28MP0000465_gastrointestinal_hemorrhage1.99114515
29MP0005174_abnormal_tail_pigmentation1.94179318
30* MP0002398_abnormal_bone_marrow1.92383152
31* MP0002405_respiratory_system_inflammati1.89686000
32* MP0003763_abnormal_thymus_physiology1.89405444
33MP0001853_heart_inflammation1.88965103
34MP0010155_abnormal_intestine_physiology1.78252169
35MP0002877_abnormal_melanocyte_morpholog1.71900814
36MP0010352_gastrointestinal_tract_polyps1.70421842
37MP0002006_tumorigenesis1.69834518
38* MP0000716_abnormal_immune_system1.69028836
39* MP0000689_abnormal_spleen_morphology1.62854663
40MP0004947_skin_inflammation1.62767927
41MP0003705_abnormal_hypodermis_morpholog1.62366918
42* MP0002722_abnormal_immune_system1.60371916
43MP0000490_abnormal_crypts_of1.57521986
44MP0001533_abnormal_skeleton_physiology1.53473006
45MP0006082_CNS_inflammation1.53127151
46MP0001873_stomach_inflammation1.51812698
47MP0004510_myositis1.49388267
48* MP0002429_abnormal_blood_cell1.46338327
49MP0003566_abnormal_cell_adhesion1.46292105
50MP0005503_abnormal_tendon_morphology1.45411388
51* MP0000703_abnormal_thymus_morphology1.42740246
52MP0002933_joint_inflammation1.40913571
53MP0006054_spinal_hemorrhage1.39460076
54MP0009333_abnormal_splenocyte_physiolog1.38996579
55MP0001845_abnormal_inflammatory_respons1.37210940
56MP0005023_abnormal_wound_healing1.36487233
57MP0008007_abnormal_cellular_replicative1.33743110
58MP0003828_pulmonary_edema1.32079641
59MP0003448_altered_tumor_morphology1.31969195
60MP0008438_abnormal_cutaneous_collagen1.27449807
61MP0003656_abnormal_erythrocyte_physiolo1.27326274
62* MP0000858_altered_metastatic_potential1.26479842
63MP0001851_eye_inflammation1.22226665
64MP0002998_abnormal_bone_remodeling1.20655141
65MP0005409_darkened_coat_color1.20356464
66MP0001542_abnormal_bone_strength1.18567648
67MP0009840_abnormal_foam_cell1.17564183
68MP0005076_abnormal_cell_differentiation1.16455864
69MP0004883_abnormal_blood_vessel1.14251311
70MP0002060_abnormal_skin_morphology1.13564880
71MP0005058_abnormal_lysosome_morphology1.12435788
72MP0000015_abnormal_ear_pigmentation1.12032275
73MP0000343_altered_response_to1.11950559
74MP0003866_abnormal_defecation1.11670217
75MP0010307_abnormal_tumor_latency1.11306336
76MP0003950_abnormal_plasma_membrane1.10701943
77MP0002132_abnormal_respiratory_system1.09649648
78MP0003045_fibrosis1.08730876
79MP0002095_abnormal_skin_pigmentation1.05104194
80MP0001958_emphysema1.01106770
81MP0008004_abnormal_stomach_pH0.99919518
82MP0005075_abnormal_melanosome_morpholog0.99526689
83MP0003172_abnormal_lysosome_physiology0.98894143
84* MP0005390_skeleton_phenotype0.98704990
85MP0003693_abnormal_embryo_hatching0.95541949
86* MP0002019_abnormal_tumor_incidence0.94614308
87MP0000733_abnormal_muscle_development0.93883013
88MP0010094_abnormal_chromosome_stability0.93222556
89MP0002254_reproductive_system_inflammat0.92568784
90MP0008469_abnormal_protein_level0.91615508
91* MP0003279_aneurysm0.91274357
92MP0005166_decreased_susceptibility_to0.91221021
93MP0008057_abnormal_DNA_replication0.90660397
94MP0003075_altered_response_to0.89739547
95MP0003795_abnormal_bone_structure0.88290445
96MP0003191_abnormal_cellular_cholesterol0.86678150
97MP0009764_decreased_sensitivity_to0.86144543
98MP0000767_abnormal_smooth_muscle0.85613770
99MP0004381_abnormal_hair_follicle0.85444424
100MP0003943_abnormal_hepatobiliary_system0.85102860
101MP0003077_abnormal_cell_cycle0.84184930
102MP0001243_abnormal_dermal_layer0.81218614
103MP0001216_abnormal_epidermal_layer0.80293228
104MP0005165_increased_susceptibility_to0.79798481
105MP0009384_cardiac_valve_regurgitation0.78347388
106MP0009931_abnormal_skin_appearance0.77395387
107MP0001849_ear_inflammation0.77170850
108MP0003091_abnormal_cell_migration0.76529176
109MP0003453_abnormal_keratinocyte_physiol0.75153593
110MP0005275_abnormal_skin_tensile0.75054994
111MP0002009_preneoplasia0.74709872
112MP0000371_diluted_coat_color0.73788406
113MP0009763_increased_sensitivity_to0.73310869
114MP0004185_abnormal_adipocyte_glucose0.72907280
115MP0010368_abnormal_lymphatic_system0.69623724
116MP0005310_abnormal_salivary_gland0.68705404
117MP0003183_abnormal_peptide_metabolism0.68297768
118MP0005164_abnormal_response_to0.67991167
119MP0000249_abnormal_blood_vessel0.66576968
120MP0003111_abnormal_nucleus_morphology0.65870090

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.38302527
2Eczematoid dermatitis (HP:0000976)4.15170724
3Recurrent bacterial skin infections (HP:0005406)4.11770970
4Myositis (HP:0100614)3.77956820
5Elevated erythrocyte sedimentation rate (HP:0003565)3.52202735
6Recurrent fungal infections (HP:0002841)3.39118905
7Cellulitis (HP:0100658)3.34217320
8Recurrent viral infections (HP:0004429)3.10810505
9Petechiae (HP:0000967)3.08907259
10IgM deficiency (HP:0002850)3.02050500
11Osteolytic defects of the phalanges of the hand (HP:0009771)2.98829910
12Osteolytic defects of the hand bones (HP:0009699)2.98829910
13Orchitis (HP:0100796)2.98288433
14Syringomyelia (HP:0003396)2.92380273
15Spinal cord lesions (HP:0100561)2.92380273
16Acute lymphatic leukemia (HP:0006721)2.84399889
17Abnormality of the fingertips (HP:0001211)2.84281388
18Prostate neoplasm (HP:0100787)2.83546118
19Thrombocytosis (HP:0001894)2.76087197
20Aortic dissection (HP:0002647)2.73824427
21Periodontitis (HP:0000704)2.72641381
22Mediastinal lymphadenopathy (HP:0100721)2.72012533
23Panhypogammaglobulinemia (HP:0003139)2.71731253
24Optic neuritis (HP:0100653)2.68156959
25Retrobulbar optic neuritis (HP:0100654)2.68156959
26* Prolonged bleeding time (HP:0003010)2.68086214
27Recurrent skin infections (HP:0001581)2.67093362
28Chronic otitis media (HP:0000389)2.62382279
29Interstitial pulmonary disease (HP:0006530)2.59425593
30Meningitis (HP:0001287)2.58476582
31Dysostosis multiplex (HP:0000943)2.55819397
32Pustule (HP:0200039)2.54718891
33Autoimmune hemolytic anemia (HP:0001890)2.53577678
34Osteomyelitis (HP:0002754)2.51787336
35Abnormality of the prostate (HP:0008775)2.50794331
36Peritonitis (HP:0002586)2.45336385
37Abnormality of liposaccharide metabolism (HP:0010968)2.42329698
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.42329698
39Abnormality of glycolipid metabolism (HP:0010969)2.42329698
40Leukocytosis (HP:0001974)2.41896169
41Eosinophilia (HP:0001880)2.40966632
42Dilatation of the ascending aorta (HP:0005111)2.39734968
43Spondylolisthesis (HP:0003302)2.39664696
44Thyroiditis (HP:0100646)2.38329807
45Recurrent cutaneous fungal infections (HP:0011370)2.36456973
46Chronic mucocutaneous candidiasis (HP:0002728)2.36456973
47Abnormality of macrophages (HP:0004311)2.36396481
48Cervical subluxation (HP:0003308)2.35719062
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.34401501
50Gingival bleeding (HP:0000225)2.30742886
51Chronic obstructive pulmonary disease (HP:0006510)2.30464489
52Obstructive lung disease (HP:0006536)2.30464489
53Vasculitis (HP:0002633)2.30306195
54Agammaglobulinemia (HP:0004432)2.30029424
55Inflammation of the large intestine (HP:0002037)2.29508942
56Abnormality of B cell number (HP:0010975)2.27076096
57B lymphocytopenia (HP:0010976)2.27076096
58Autoimmune thrombocytopenia (HP:0001973)2.26964450
59Absent frontal sinuses (HP:0002688)2.26329424
60Vascular tortuosity (HP:0004948)2.22934975
61Gastrointestinal inflammation (HP:0004386)2.20474753
62Gingivitis (HP:0000230)2.20327036
63Increased density of long bones (HP:0006392)2.20120477
64Arterial thrombosis (HP:0004420)2.17961385
65Abnormal platelet volume (HP:0011876)2.15176538
66Broad face (HP:0000283)2.14783916
67* Acute myeloid leukemia (HP:0004808)2.14611010
68* Epistaxis (HP:0000421)2.14120169
69Fragile skin (HP:0001030)2.13012590
70Urinary glycosaminoglycan excretion (HP:0003541)2.12996840
71Mucopolysacchariduria (HP:0008155)2.12996840
72T lymphocytopenia (HP:0005403)2.12938322
73Arterial tortuosity (HP:0005116)2.12818048
74Abnormality of polysaccharide metabolism (HP:0011012)2.12524181
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12524181
76Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12524181
77Spontaneous hematomas (HP:0007420)2.10895968
78Urethral obstruction (HP:0000796)2.09105997
79Delayed closure of the anterior fontanelle (HP:0001476)2.08694125
80Hematochezia (HP:0002573)2.08278089
81Granulocytopenia (HP:0001913)2.05650656
82Aneurysm (HP:0002617)2.05026723
83Abnormality of eosinophils (HP:0001879)2.03554979
84Abnormality of T cell number (HP:0011839)2.02978496
85Recurrent bronchitis (HP:0002837)2.02604788
86Aortic regurgitation (HP:0001659)2.02386682
87Lip pit (HP:0100267)2.02175388
88Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.02057708
89Abnormality of T cells (HP:0002843)2.02007788
90Increased IgE level (HP:0003212)2.01417712
91Follicular hyperkeratosis (HP:0007502)2.00793293
92Thick nail (HP:0001805)2.00581760
93* Impaired platelet aggregation (HP:0003540)1.96103935
94* Abnormal platelet function (HP:0011869)1.96103935
95Distal lower limb amyotrophy (HP:0008944)1.95526035
96Cerebral aneurysm (HP:0004944)1.95443518
97Submucous cleft hard palate (HP:0000176)1.95257889
98Distal lower limb muscle weakness (HP:0009053)1.93815755
99Aortic aneurysm (HP:0004942)1.93496618
100Colitis (HP:0002583)1.91706006
101Recurrent gram-negative bacterial infections (HP:0005420)1.91192851
102Vacuolated lymphocytes (HP:0001922)1.90842240
103Polygenic inheritance (HP:0010982)1.90760471
104Entropion (HP:0000621)1.89772339
105Thoracic kyphosis (HP:0002942)1.89109939
106Blue sclerae (HP:0000592)1.88978479
107Abnormality of T cell physiology (HP:0011840)1.88133484
108Increased neuronal autofluorescent lipopigment (HP:0002074)1.87487228
109Wormian bones (HP:0002645)1.86977749
110Genu recurvatum (HP:0002816)1.86299380
111Pulmonary infiltrates (HP:0002113)1.85807347
112Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84747186
113Reticulocytopenia (HP:0001896)1.84159120
114Skin ulcer (HP:0200042)1.82771723
115Abnormality of the thoracic spine (HP:0100711)1.81956021
116Keratoconjunctivitis sicca (HP:0001097)1.81613730
117Increased cerebral lipofuscin (HP:0011813)1.80223646
118Recurrent pneumonia (HP:0006532)1.79539551
119Stomatitis (HP:0010280)1.79396836
120Atrophic scars (HP:0001075)1.78256512
121* Bruising susceptibility (HP:0000978)1.77174748
122Joint stiffness (HP:0001387)1.76442761
123Increased mean platelet volume (HP:0011877)1.76385022
124Vertebral compression fractures (HP:0002953)1.75458104
125Mitral valve prolapse (HP:0001634)1.73576694
126Abnormality of the nasal mucosa (HP:0000433)1.73467326
127Abnormality of the columella (HP:0009929)1.72535957
128Sparse lateral eyebrow (HP:0005338)1.72394922
129Premature rupture of membranes (HP:0001788)1.72387365
130Recurrent lower respiratory tract infections (HP:0002783)1.72143409
131Hemoptysis (HP:0002105)1.70699242
132Sepsis (HP:0100806)1.70163144
133Obstructive sleep apnea (HP:0002870)1.69170916
134Chronic diarrhea (HP:0002028)1.68946820
135Abnormality of the peritoneum (HP:0002585)1.68343261
136Thin bony cortex (HP:0002753)1.67962633
137Chest pain (HP:0100749)1.67840493
138Glomerulopathy (HP:0100820)1.67649150
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67599838
140Increased variability in muscle fiber diameter (HP:0003557)1.67581446
141Protrusio acetabuli (HP:0003179)1.65427507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.67841105
2TXK2.73154827
3KIT2.69806257
4PRPF4B2.32428677
5STK102.09331514
6MAP3K142.08275920
7JAK32.06547058
8IRAK42.05162758
9TGFBR22.03741167
10TEC2.02119795
11PIM22.01490331
12ZAP701.98685118
13BTK1.95245654
14TYK21.90802590
15NME21.82785785
16RPS6KA41.82713142
17EEF2K1.82680312
18MAP2K31.79970718
19TBK11.75519418
20IKBKB1.68280877
21BLK1.64222114
22MAP3K131.60889725
23EPHB11.60852990
24IKBKE1.55876692
25IRAK31.50513108
26NEK91.49441063
27EPHA31.48393678
28CDC42BPA1.47545553
29ERN11.46571118
30MAP3K101.45643590
31MAP3K31.42095582
32CSF1R1.38104888
33TAOK31.37974674
34PDGFRA1.37347696
35PIM11.36210637
36MAP3K61.35544340
37CLK11.33877941
38AKT31.33018973
39SMG11.32909563
40SYK1.31787126
41CDK121.31191763
42HCK1.30716637
43TRPM71.29650198
44CHUK1.29366143
45SIK11.28393173
46JAK11.27951247
47RIPK41.26959464
48NLK1.22802765
49ITK1.21257699
50RPS6KB21.20782115
51FGFR31.20314786
52LRRK21.19722651
53LCK1.12938413
54RIPK11.04476185
55BMPR21.02900404
56MAP3K71.01826250
57SIK31.00671786
58DDR20.98711418
59MATK0.98289986
60PRKD20.96541047
61MAP3K10.96201153
62FLT30.96123070
63IRAK10.95291932
64MST40.94933233
65ZAK0.93637212
66FGFR40.92475485
67LYN0.92185006
68CDK80.91502516
69CSK0.91150292
70MAPK150.89932597
71MARK20.89701308
72STK40.88805480
73TGFBR10.87401224
74ICK0.87271613
75PAK40.87202190
76MELK0.87068374
77MKNK10.83761060
78MAP3K20.80371368
79PAK20.78981849
80GRK70.78975204
81MAPKAPK50.78899932
82MAPK110.78247645
83CDK90.78205973
84FES0.77985590
85MAPKAPK20.75608587
86TAOK20.75307856
87RPS6KA60.74854826
88* HIPK20.74824488
89MTOR0.74416674
90STK380.72103244
91STK30.67274419
92MYLK0.63991879
93CDC70.63826670
94PIK3CG0.63538714
95RPS6KL10.62672658
96RPS6KC10.62672658
97MARK30.62312143
98JAK20.60303996
99EPHA20.59842626
100CAMK1D0.59541101
101MKNK20.59376019
102MAPK40.58928996
103WNK10.58197663
104ATR0.57294878
105PKN20.56009043
106NUAK10.55916537
107SIK20.54775949
108RPS6KA50.54601149
109MAPKAPK30.54538329
110TTN0.54377317
111TRIB30.54367321
112MST1R0.53389108
113TAOK10.52898955
114MAP3K110.51244800
115BRD40.51100192
116PDGFRB0.51062142
117PTK60.50199555
118FRK0.49935441
119CDK40.49549483
120VRK10.48138186
121CDK70.47957622
122MAP3K80.47734846
123MOS0.47328705
124ADRBK20.46743232
125STK240.44183857
126ABL10.43030945
127TNK20.42773908
128GRK60.41231385
129ERBB30.40319861
130MAP2K20.40166402
131MAPK70.39551313
132RPS6KA20.38174199

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.54775438
2Primary immunodeficiency_Homo sapiens_hsa053402.17935680
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.15390737
4Osteoclast differentiation_Homo sapiens_hsa043802.12990714
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07573264
6Hematopoietic cell lineage_Homo sapiens_hsa046402.04831044
7B cell receptor signaling pathway_Homo sapiens_hsa046622.03680252
8Measles_Homo sapiens_hsa051621.95854130
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80447723
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.71237500
11Malaria_Homo sapiens_hsa051441.68006408
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64901012
13Toxoplasmosis_Homo sapiens_hsa051451.61958549
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.51841655
15Antigen processing and presentation_Homo sapiens_hsa046121.51439574
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49661098
17Pertussis_Homo sapiens_hsa051331.49418443
18Legionellosis_Homo sapiens_hsa051341.44662100
19Herpes simplex infection_Homo sapiens_hsa051681.44013580
20Hepatitis B_Homo sapiens_hsa051611.43952265
21TNF signaling pathway_Homo sapiens_hsa046681.43329736
22Non-homologous end-joining_Homo sapiens_hsa034501.42008193
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39635486
24DNA replication_Homo sapiens_hsa030301.39473775
25Apoptosis_Homo sapiens_hsa042101.38788955
26* Chronic myeloid leukemia_Homo sapiens_hsa052201.38407388
27Tuberculosis_Homo sapiens_hsa051521.37763571
28Influenza A_Homo sapiens_hsa051641.37195852
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36030399
30* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.33478004
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33131735
32T cell receptor signaling pathway_Homo sapiens_hsa046601.31153182
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31003496
34Dorso-ventral axis formation_Homo sapiens_hsa043201.30041843
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29192670
36* Acute myeloid leukemia_Homo sapiens_hsa052211.28219619
37Asthma_Homo sapiens_hsa053101.26612595
38Platelet activation_Homo sapiens_hsa046111.26220041
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25331971
40Shigellosis_Homo sapiens_hsa051311.24970540
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20783140
42Renal cell carcinoma_Homo sapiens_hsa052111.20148305
43Small cell lung cancer_Homo sapiens_hsa052221.19972915
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.18905844
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.17734308
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15046750
47Pancreatic cancer_Homo sapiens_hsa052121.14626594
48Salmonella infection_Homo sapiens_hsa051321.12027472
49Ribosome_Homo sapiens_hsa030101.10980984
50Allograft rejection_Homo sapiens_hsa053301.10835231
51Bladder cancer_Homo sapiens_hsa052191.08575015
52Base excision repair_Homo sapiens_hsa034101.04607267
53Graft-versus-host disease_Homo sapiens_hsa053321.03707751
54Viral myocarditis_Homo sapiens_hsa054161.02224148
55Chemokine signaling pathway_Homo sapiens_hsa040621.00648630
56HTLV-I infection_Homo sapiens_hsa051661.00226809
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98921392
58p53 signaling pathway_Homo sapiens_hsa041150.97818075
59Staphylococcus aureus infection_Homo sapiens_hsa051500.97228636
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96319041
61Viral carcinogenesis_Homo sapiens_hsa052030.91498804
62Other glycan degradation_Homo sapiens_hsa005110.90343660
63Homologous recombination_Homo sapiens_hsa034400.90251774
64MicroRNAs in cancer_Homo sapiens_hsa052060.88002591
65Epstein-Barr virus infection_Homo sapiens_hsa051690.86808154
66Rheumatoid arthritis_Homo sapiens_hsa053230.86359993
67Cell cycle_Homo sapiens_hsa041100.82691220
68mTOR signaling pathway_Homo sapiens_hsa041500.81881912
69ECM-receptor interaction_Homo sapiens_hsa045120.81156929
70Non-small cell lung cancer_Homo sapiens_hsa052230.79687451
71Hepatitis C_Homo sapiens_hsa051600.79404332
72Lysosome_Homo sapiens_hsa041420.76698165
73Prolactin signaling pathway_Homo sapiens_hsa049170.76559016
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.74980384
75Proteoglycans in cancer_Homo sapiens_hsa052050.74325390
76Amoebiasis_Homo sapiens_hsa051460.74225211
77Mismatch repair_Homo sapiens_hsa034300.73189407
78Colorectal cancer_Homo sapiens_hsa052100.73186021
79Insulin resistance_Homo sapiens_hsa049310.71585075
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70997423
81Phagosome_Homo sapiens_hsa041450.70745458
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.69884586
83Type I diabetes mellitus_Homo sapiens_hsa049400.69702905
84Glioma_Homo sapiens_hsa052140.69692722
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69029624
86Notch signaling pathway_Homo sapiens_hsa043300.68516187
87Prostate cancer_Homo sapiens_hsa052150.68367893
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67342038
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66885293
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66500314
91Fanconi anemia pathway_Homo sapiens_hsa034600.65579743
92Focal adhesion_Homo sapiens_hsa045100.65546699
93MAPK signaling pathway_Homo sapiens_hsa040100.65541837
94Choline metabolism in cancer_Homo sapiens_hsa052310.63509239
95GnRH signaling pathway_Homo sapiens_hsa049120.63276733
96Caffeine metabolism_Homo sapiens_hsa002320.62248835
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60056494
98FoxO signaling pathway_Homo sapiens_hsa040680.60055446
99Thyroid cancer_Homo sapiens_hsa052160.59509625
100Endometrial cancer_Homo sapiens_hsa052130.57573403
101African trypanosomiasis_Homo sapiens_hsa051430.56161851
102Adherens junction_Homo sapiens_hsa045200.55133834
103ErbB signaling pathway_Homo sapiens_hsa040120.55030122
104* Pathways in cancer_Homo sapiens_hsa052000.54739996
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.54131859
106Autoimmune thyroid disease_Homo sapiens_hsa053200.53779161
107TGF-beta signaling pathway_Homo sapiens_hsa043500.53483916
108HIF-1 signaling pathway_Homo sapiens_hsa040660.53468598
109Inositol phosphate metabolism_Homo sapiens_hsa005620.53048006
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52600826
111Renin-angiotensin system_Homo sapiens_hsa046140.50688436
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50116400
113Nucleotide excision repair_Homo sapiens_hsa034200.49952259
114Endocytosis_Homo sapiens_hsa041440.47645478
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47457902
116RNA degradation_Homo sapiens_hsa030180.45824495
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43736880
118Spliceosome_Homo sapiens_hsa030400.43665702
119VEGF signaling pathway_Homo sapiens_hsa043700.38511174
120Melanoma_Homo sapiens_hsa052180.38094010
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.36713393

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