RUNX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte aggregation (GO:0070486)4.79571764
2germinal center formation (GO:0002467)4.56069332
3definitive hemopoiesis (GO:0060216)4.53303754
4regulation of B cell receptor signaling pathway (GO:0050855)4.34032297
5cellular response to ethanol (GO:0071361)4.25862741
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.24900870
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13196991
8antigen processing and presentation of endogenous antigen (GO:0019883)4.08973548
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90021910
10positive regulation of gamma-delta T cell activation (GO:0046645)3.84835649
11immunoglobulin mediated immune response (GO:0016064)3.83598384
12negative T cell selection (GO:0043383)3.72206500
13negative thymic T cell selection (GO:0045060)3.71035795
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.67816182
15mast cell activation (GO:0045576)3.65900266
16positive regulation by symbiont of host defense response (GO:0052509)3.55851997
17modulation by symbiont of host defense response (GO:0052031)3.55851997
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.55851997
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.55851997
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.55851997
21modulation by symbiont of host immune response (GO:0052553)3.55851997
22skin morphogenesis (GO:0043589)3.49741955
23regulation of gamma-delta T cell activation (GO:0046643)3.47787959
24regulation of B cell differentiation (GO:0045577)3.44982630
25negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.41759852
26macrophage differentiation (GO:0030225)3.41061508
27negative regulation of T-helper cell differentiation (GO:0045623)3.41044710
28negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.41044710
29positive thymic T cell selection (GO:0045059)3.40453642
30regulation of gamma-delta T cell differentiation (GO:0045586)3.36710277
31positive regulation of alpha-beta T cell proliferation (GO:0046641)3.34274441
32regulation of alpha-beta T cell proliferation (GO:0046640)3.33780325
33cellular response to interleukin-15 (GO:0071350)3.33102338
34mature B cell differentiation (GO:0002335)3.31731233
35mature B cell differentiation involved in immune response (GO:0002313)3.29267555
36response to muramyl dipeptide (GO:0032495)3.26614004
37response to peptidoglycan (GO:0032494)3.26549133
38negative regulation of interleukin-12 production (GO:0032695)3.22580464
39cellular extravasation (GO:0045123)3.21130592
40myeloid cell activation involved in immune response (GO:0002275)3.19073271
41positive T cell selection (GO:0043368)3.18971982
42B cell mediated immunity (GO:0019724)3.17177850
43defense response to protozoan (GO:0042832)3.15057044
44negative regulation of phagocytosis (GO:0050765)3.13424414
45lymphoid progenitor cell differentiation (GO:0002320)3.11408457
46histone H3-K4 trimethylation (GO:0080182)3.10704700
47response to protozoan (GO:0001562)3.09953021
48B cell receptor signaling pathway (GO:0050853)3.09453491
49interferon-gamma production (GO:0032609)3.08375401
50regulation of T-helper 1 cell differentiation (GO:0045625)3.06599544
51detection of molecule of bacterial origin (GO:0032490)3.06236295
52response to interleukin-15 (GO:0070672)3.06145514
53neutrophil activation involved in immune response (GO:0002283)3.03722570
54macrophage activation involved in immune response (GO:0002281)3.03469046
55megakaryocyte development (GO:0035855)3.03415900
56T cell migration (GO:0072678)3.03411043
57detection of other organism (GO:0098543)3.00528561
58positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.99954705
59T cell selection (GO:0045058)2.98689180
60negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.98214728
61positive regulation of granulocyte differentiation (GO:0030854)2.97547265
62dendritic cell migration (GO:0036336)2.97257267
63positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.96035674
64positive regulation of interleukin-17 production (GO:0032740)2.95752090
65regulation of dendritic cell antigen processing and presentation (GO:0002604)2.95731069
66negative regulation of cell killing (GO:0031342)2.94520347
67negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.94520347
68regulation of interleukin-17 production (GO:0032660)2.94297649
69regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.90958219
70angiogenesis involved in wound healing (GO:0060055)2.90630896
71dendritic cell chemotaxis (GO:0002407)2.90543141
72detection of bacterium (GO:0016045)2.89758520
73mast cell activation involved in immune response (GO:0002279)2.88789820
74mast cell degranulation (GO:0043303)2.88789820
75response to type I interferon (GO:0034340)2.88379818
76type I interferon signaling pathway (GO:0060337)2.86754593
77cellular response to type I interferon (GO:0071357)2.86754593
78thymic T cell selection (GO:0045061)2.84414589
79negative regulation of type 2 immune response (GO:0002829)2.82926131
80Arp2/3 complex-mediated actin nucleation (GO:0034314)2.82135339
81detection of external biotic stimulus (GO:0098581)2.81980802
82regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.81913694
83response to host (GO:0075136)2.81842610
84response to host defenses (GO:0052200)2.81842610
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.81842610
86regulation of tolerance induction (GO:0002643)2.80400417
87regulation of mast cell activation involved in immune response (GO:0033006)2.79365399
88regulation of mast cell activation (GO:0033003)2.78468289
89positive regulation of mast cell activation (GO:0033005)2.77606691
90B cell homeostasis (GO:0001782)2.76146335
91B cell differentiation (GO:0030183)2.75865024
92response to host immune response (GO:0052572)2.75682436
93response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75682436
94respiratory burst (GO:0045730)2.75633877
95positive regulation of macrophage differentiation (GO:0045651)2.74640491
96interferon-gamma-mediated signaling pathway (GO:0060333)2.74582377
97T cell homeostasis (GO:0043029)2.72812448
98negative regulation of interleukin-17 production (GO:0032700)2.70847027
99positive regulation of tolerance induction (GO:0002645)2.70822863
100positive regulation of isotype switching (GO:0045830)2.70635407
101negative regulation of lymphocyte mediated immunity (GO:0002707)2.70448767
102positive regulation of T cell mediated cytotoxicity (GO:0001916)2.70356856
103microglial cell activation (GO:0001774)2.69502173
104negative regulation of interleukin-8 production (GO:0032717)2.69486448
105positive regulation of mast cell activation involved in immune response (GO:0033008)2.69393745
106positive regulation of mast cell degranulation (GO:0043306)2.69393745
107lipopolysaccharide-mediated signaling pathway (GO:0031663)2.69081503
108positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68404178
109cellular defense response (GO:0006968)2.68044645
110positive regulation of interferon-alpha production (GO:0032727)2.66831023
111response to interferon-alpha (GO:0035455)2.66167574
112regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.66087985
113neutrophil activation (GO:0042119)2.65952785
114lymph node development (GO:0048535)2.64498313
115mesenchymal-epithelial cell signaling (GO:0060638)2.63119705
116leukocyte cell-cell adhesion (GO:0007159)2.60451449
117RNA destabilization (GO:0050779)2.59923712
118negative regulation of T cell mediated immunity (GO:0002710)2.58951361
119positive regulation of B cell differentiation (GO:0045579)2.58384006
120superoxide anion generation (GO:0042554)2.54869207
121regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.54445367
122amyloid precursor protein catabolic process (GO:0042987)2.53886909
123negative regulation of nitric oxide biosynthetic process (GO:0045019)2.49216823
124myeloid dendritic cell activation (GO:0001773)2.49107249
125positive regulation of T cell chemotaxis (GO:0010820)2.48831643
126regulation of T cell chemotaxis (GO:0010819)2.48831643
127leukocyte homeostasis (GO:0001776)2.48296174
128positive regulation of DNA recombination (GO:0045911)2.47518702
129negative regulation of viral genome replication (GO:0045071)2.46520076
130energy homeostasis (GO:0097009)2.45018707
131regulation of necroptotic process (GO:0060544)2.44613118
132lymphocyte homeostasis (GO:0002260)2.43080730
133positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.40476902
134T cell activation involved in immune response (GO:0002286)2.40024401
135CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.39648527
136tolerance induction (GO:0002507)2.39110502
137regulation of T cell mediated cytotoxicity (GO:0001914)2.38445673
138myoblast migration (GO:0051451)2.38379811
139B cell activation (GO:0042113)2.37286911
140negative regulation of B cell activation (GO:0050869)2.37124951
141regulation of cellular extravasation (GO:0002691)2.36717641
142granulocyte activation (GO:0036230)2.35097838
143positive regulation of interleukin-1 beta secretion (GO:0050718)2.34304647
144CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.34040939
145T-helper cell differentiation (GO:0042093)2.34040939
146polyketide metabolic process (GO:0030638)2.33098551
147doxorubicin metabolic process (GO:0044598)2.33098551
148daunorubicin metabolic process (GO:0044597)2.33098551
149embryonic hemopoiesis (GO:0035162)2.32784714
150positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.32313609
151regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.31786928
152leukocyte degranulation (GO:0043299)2.30958144
153regulation of interleukin-12 biosynthetic process (GO:0045075)2.30955972
154negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.30366789
155positive regulation of odontogenesis (GO:0042482)2.30239084
156neutrophil mediated immunity (GO:0002446)2.30003913
157hepatocyte apoptotic process (GO:0097284)2.29716545
158negative regulation of B cell proliferation (GO:0030889)2.29505304
159CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.29335750
160regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.28925891
161negative regulation of leukocyte mediated immunity (GO:0002704)2.28025613
162regulation of mast cell degranulation (GO:0043304)2.27479907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.28228850
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.41629782
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.35481463
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.14699487
5* SCL_19346495_ChIP-Seq_HPC-7_Human3.33515182
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.06692848
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03534566
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.97807664
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.70765136
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.47822810
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45624498
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.45017784
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43945746
14GATA1_22025678_ChIP-Seq_K562_Human2.40777481
15* RUNX_20019798_ChIP-Seq_JUKART_Human2.36177052
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33586128
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13018845
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12900284
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03121713
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01552283
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98415949
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95304529
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.91960154
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84383650
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.83785077
26MYB_26560356_Chip-Seq_TH2_Human1.81989398
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80212338
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.76381600
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76372504
30IGF1R_20145208_ChIP-Seq_DFB_Human1.72141074
31SPI1_23547873_ChIP-Seq_NB4_Human1.72000992
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71564805
33VDR_24763502_ChIP-Seq_THP-1_Human1.69729331
34GATA3_26560356_Chip-Seq_TH2_Human1.68495820
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65757220
36MYC_22102868_ChIP-Seq_BL_Human1.65094889
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.64484221
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63241478
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62405918
40TP53_16413492_ChIP-PET_HCT116_Human1.59281015
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57487397
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57203128
43VDR_24787735_ChIP-Seq_THP-1_Human1.55488616
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54946127
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.54710892
46* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52788288
47* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52663655
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52083987
49MYB_26560356_Chip-Seq_TH1_Human1.51691556
50* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50649095
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48856575
52MAF_26560356_Chip-Seq_TH2_Human1.44298435
53VDR_21846776_ChIP-Seq_THP-1_Human1.44170779
54TCF7_22412390_ChIP-Seq_EML_Mouse1.43281842
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42991746
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41356582
57PU_27001747_Chip-Seq_BMDM_Mouse1.34548027
58TAF15_26573619_Chip-Seq_HEK293_Human1.34392375
59SPI1_23127762_ChIP-Seq_K562_Human1.33880979
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33312109
61TP53_18474530_ChIP-ChIP_U2OS_Human1.32172801
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.31882229
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31521006
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.31316622
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.28788081
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28395112
67* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28056156
68* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28004391
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.25886960
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23788095
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23205580
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.18333043
73P53_22387025_ChIP-Seq_ESCs_Mouse1.18294202
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18088958
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17348403
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16421691
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14934517
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14452577
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14263704
80MAF_26560356_Chip-Seq_TH1_Human1.13946816
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13341523
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12016146
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.11109216
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10311274
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09939931
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09540875
87* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09029213
88FUS_26573619_Chip-Seq_HEK293_Human1.08365495
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08003996
90P300_19829295_ChIP-Seq_ESCs_Human1.05979550
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04844199
92GBX2_23144817_ChIP-Seq_PC3_Human1.04833289
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04039408
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03829247
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03793695
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03640057
97ER_23166858_ChIP-Seq_MCF-7_Human1.03582416
98EWS_26573619_Chip-Seq_HEK293_Human1.03160760
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02128265
100E2F7_22180533_ChIP-Seq_HELA_Human1.01407514
101KDM2B_26808549_Chip-Seq_DND41_Human1.01017126
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.00392809
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00344286
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99039869
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98954205
106TRIM28_21343339_ChIP-Seq_HEK293_Human0.98915548
107* BRD4_25478319_ChIP-Seq_HGPS_Human0.98804950
108VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98241819
109* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97798402
110ESR1_20079471_ChIP-ChIP_T-47D_Human0.97764714
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97251229
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96659505
113PU1_27457419_Chip-Seq_LIVER_Mouse0.96630537
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95608980
115GATA3_27048872_Chip-Seq_THYMUS_Human0.95288769
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95066039
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94973086
118P300_18555785_Chip-Seq_ESCs_Mouse0.94721012
119* GATA1_19941827_ChIP-Seq_MEL_Mouse0.94646776
120* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93697677
121NMYC_18555785_Chip-Seq_ESCs_Mouse0.93038135
122STAT3_18555785_Chip-Seq_ESCs_Mouse0.92396099
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91468258
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90797802
125* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90777544
126STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90531224
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89779523
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89494761
129OCT4_18555785_Chip-Seq_ESCs_Mouse0.88321664
130UTX_26944678_Chip-Seq_JUKART_Human0.87919398
131BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87351122
132CJUN_26792858_Chip-Seq_BT549_Human0.86470103
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86367811
134GATA2_19941826_ChIP-Seq_K562_Human0.86250499
135CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85675266
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84929658
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84858599
138CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84654163
139GATA1_19941826_ChIP-Seq_K562_Human0.84173138
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.84061324
141SOX2_18555785_Chip-Seq_ESCs_Mouse0.82820136
142IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82520446
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82210560
144FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81972848
145CIITA_25753668_ChIP-Seq_RAJI_Human0.81392916
146ELK3_25401928_ChIP-Seq_HUVEC_Human0.79396053
147SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78821408
148SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78821408
149* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76085707
150SMRT_27268052_Chip-Seq_Bcells_Human0.74734496

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage3.75855119
2MP0002396_abnormal_hematopoietic_system3.35259162
3MP0001835_abnormal_antigen_presentation3.24377869
4MP0005174_abnormal_tail_pigmentation2.67836926
5MP0005671_abnormal_response_to2.58893095
6MP0000685_abnormal_immune_system2.49975852
7MP0000569_abnormal_digit_pigmentation2.45016092
8MP0005409_darkened_coat_color2.28689429
9MP0003436_decreased_susceptibility_to2.25917368
10MP0002148_abnormal_hypersensitivity_rea2.25857307
11MP0009785_altered_susceptibility_to2.21714712
12MP0002419_abnormal_innate_immunity2.21426525
13MP0002009_preneoplasia2.20240857
14MP0002452_abnormal_antigen_presenting2.17760188
15MP0005000_abnormal_immune_tolerance2.15962373
16MP0005025_abnormal_response_to2.15746797
17MP0001800_abnormal_humoral_immune2.15462697
18MP0002420_abnormal_adaptive_immunity2.09582931
19MP0002723_abnormal_immune_serum2.08455720
20MP0001819_abnormal_immune_cell2.08445995
21MP0004808_abnormal_hematopoietic_stem2.07015261
22MP0000015_abnormal_ear_pigmentation2.05333420
23MP0005503_abnormal_tendon_morphology2.03625548
24MP0001790_abnormal_immune_system2.02237562
25MP0005387_immune_system_phenotype2.02237562
26MP0006082_CNS_inflammation1.99324139
27MP0002166_altered_tumor_susceptibility1.97539240
28MP0002933_joint_inflammation1.82423087
29* MP0002398_abnormal_bone_marrow1.81396832
30MP0005464_abnormal_platelet_physiology1.75558421
31MP0002006_tumorigenesis1.75411265
32MP0003279_aneurysm1.71165936
33* MP0000716_abnormal_immune_system1.69094176
34MP0001851_eye_inflammation1.67261640
35MP0003191_abnormal_cellular_cholesterol1.65479744
36MP0003763_abnormal_thymus_physiology1.64807410
37MP0000465_gastrointestinal_hemorrhage1.63013501
38MP0008438_abnormal_cutaneous_collagen1.60433402
39* MP0002998_abnormal_bone_remodeling1.57746548
40MP0009764_decreased_sensitivity_to1.57560380
41MP0001873_stomach_inflammation1.50112080
42MP0002095_abnormal_skin_pigmentation1.49871819
43MP0002405_respiratory_system_inflammati1.47935891
44MP0003724_increased_susceptibility_to1.47848444
45* MP0002722_abnormal_immune_system1.42191177
46MP0000858_altered_metastatic_potential1.38932460
47MP0001188_hyperpigmentation1.37261597
48MP0003303_peritoneal_inflammation1.36870517
49MP0003787_abnormal_imprinting1.35397238
50* MP0000703_abnormal_thymus_morphology1.33783005
51MP0001533_abnormal_skeleton_physiology1.33466564
52* MP0000689_abnormal_spleen_morphology1.31430709
53* MP0002429_abnormal_blood_cell1.30853424
54MP0005397_hematopoietic_system_phenotyp1.29581154
55MP0001545_abnormal_hematopoietic_system1.29581154
56MP0001853_heart_inflammation1.28972738
57MP0009384_cardiac_valve_regurgitation1.26185997
58MP0003448_altered_tumor_morphology1.26069683
59MP0004510_myositis1.25779124
60MP0003866_abnormal_defecation1.25488504
61MP0002249_abnormal_larynx_morphology1.25220177
62MP0005075_abnormal_melanosome_morpholog1.23828239
63MP0010155_abnormal_intestine_physiology1.22519446
64* MP0009250_abnormal_appendicular_skeleto1.20764971
65MP0003172_abnormal_lysosome_physiology1.13907339
66MP0004947_skin_inflammation1.13088082
67MP0003183_abnormal_peptide_metabolism1.12880628
68MP0003075_altered_response_to1.10041743
69MP0009278_abnormal_bone_marrow1.09777175
70* MP0005390_skeleton_phenotype1.09208441
71MP0001845_abnormal_inflammatory_respons1.08560118
72* MP0003795_abnormal_bone_structure1.06642810
73MP0008057_abnormal_DNA_replication1.06361594
74* MP0002113_abnormal_skeleton_development1.06101672
75MP0000490_abnormal_crypts_of1.01798534
76MP0002177_abnormal_outer_ear1.00410316
77MP0003656_abnormal_erythrocyte_physiolo1.00314578
78MP0001958_emphysema1.00085978
79MP0002089_abnormal_postnatal_growth/wei0.99895461
80MP0003300_gastrointestinal_ulcer0.99408590
81MP0004381_abnormal_hair_follicle0.97742944
82MP0008004_abnormal_stomach_pH0.97578175
83MP0004134_abnormal_chest_morphology0.96651639
84MP0009379_abnormal_foot_pigmentation0.95135339
85MP0005166_decreased_susceptibility_to0.94933377
86MP0002102_abnormal_ear_morphology0.94600158
87MP0005023_abnormal_wound_healing0.92357390
88MP0009763_increased_sensitivity_to0.92106631
89MP0003828_pulmonary_edema0.91533272
90MP0009333_abnormal_splenocyte_physiolog0.91223887
91MP0001542_abnormal_bone_strength0.88855084
92MP0006292_abnormal_olfactory_placode0.88718145
93MP0000049_abnormal_middle_ear0.88109289
94MP0000343_altered_response_to0.87933748
95MP0002019_abnormal_tumor_incidence0.86777859
96MP0003950_abnormal_plasma_membrane0.85253430
97MP0005310_abnormal_salivary_gland0.84822245
98MP0003091_abnormal_cell_migration0.84803397
99MP0004883_abnormal_blood_vessel0.83622376
100MP0000767_abnormal_smooth_muscle0.83178303
101MP0001915_intracranial_hemorrhage0.81152275
102* MP0000249_abnormal_blood_vessel0.81098334
103MP0005275_abnormal_skin_tensile0.79359214
104MP0008469_abnormal_protein_level0.79308794
105MP0002938_white_spotting0.77987944
106MP0005451_abnormal_body_composition0.77924035
107MP0002877_abnormal_melanocyte_morpholog0.76807013
108* MP0005508_abnormal_skeleton_morphology0.74894579
109MP0002928_abnormal_bile_duct0.74055921
110MP0009765_abnormal_xenobiotic_induced0.73411373
111MP0003045_fibrosis0.72524298
112* MP0000163_abnormal_cartilage_morphology0.72191101
113MP0005164_abnormal_response_to0.71440220
114MP0001663_abnormal_digestive_system0.70710449
115* MP0002109_abnormal_limb_morphology0.69973321
116MP0005379_endocrine/exocrine_gland_phen0.69940224
117MP0002132_abnormal_respiratory_system0.69622911
118* MP0002115_abnormal_skeleton_extremities0.69495169
119MP0005165_increased_susceptibility_to0.69291031
120MP0002332_abnormal_exercise_endurance0.66702038
121MP0005058_abnormal_lysosome_morphology0.65092130
122MP0008007_abnormal_cellular_replicative0.63395539
123MP0005076_abnormal_cell_differentiation0.55749279
124MP0008873_increased_physiological_sensi0.51994224
125MP0001348_abnormal_lacrimal_gland0.51185373

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.29685452
2Recurrent abscess formation (HP:0002722)5.18852067
3Prostate neoplasm (HP:0100787)4.45075414
4Eczematoid dermatitis (HP:0000976)3.77678345
5Abnormality of the prostate (HP:0008775)3.54016698
6Myositis (HP:0100614)3.51955801
7* Spondylolisthesis (HP:0003302)3.42703614
8Recurrent skin infections (HP:0001581)3.40237777
9Gastrointestinal infarctions (HP:0005244)3.39677672
10Agnosia (HP:0010524)3.36732002
11Papilledema (HP:0001085)3.35340671
12Autoimmune hemolytic anemia (HP:0001890)3.32866792
13Panhypogammaglobulinemia (HP:0003139)3.26298685
14Chest pain (HP:0100749)3.12312656
15Granulocytopenia (HP:0001913)3.10112833
16* Metaphyseal dysplasia (HP:0100255)3.07567217
17Retrobulbar optic neuritis (HP:0100654)3.05854915
18Optic neuritis (HP:0100653)3.05854915
19Obstructive lung disease (HP:0006536)3.05154658
20Chronic obstructive pulmonary disease (HP:0006510)3.05154658
21Recurrent fungal infections (HP:0002841)3.03113984
22Disinhibition (HP:0000734)2.93558500
23Eosinophilia (HP:0001880)2.92373268
24IgM deficiency (HP:0002850)2.91888435
25Recurrent viral infections (HP:0004429)2.87527650
26Abnormality of eosinophils (HP:0001879)2.84086200
27Mediastinal lymphadenopathy (HP:0100721)2.78099778
28Thrombocytosis (HP:0001894)2.77891218
29Acute myeloid leukemia (HP:0004808)2.73988406
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.71981091
31Orchitis (HP:0100796)2.69739621
32Meningitis (HP:0001287)2.67295321
33Urticaria (HP:0001025)2.64122935
34Severe combined immunodeficiency (HP:0004430)2.62964806
35Elevated erythrocyte sedimentation rate (HP:0003565)2.56493603
36Pustule (HP:0200039)2.55764827
37Protrusio acetabuli (HP:0003179)2.47653336
38Asymmetry of the thorax (HP:0001555)2.46503203
39* Spinal cord lesions (HP:0100561)2.45395957
40* Syringomyelia (HP:0003396)2.45395957
41Recurrent cutaneous fungal infections (HP:0011370)2.44956502
42Chronic mucocutaneous candidiasis (HP:0002728)2.44956502
43Autoimmune thrombocytopenia (HP:0001973)2.44048793
44Cellulitis (HP:0100658)2.43559604
45Increased IgE level (HP:0003212)2.43362590
46Inflammation of the large intestine (HP:0002037)2.42487449
47Patchy hypopigmentation of hair (HP:0011365)2.41035895
48Abnormality of macrophages (HP:0004311)2.41002297
49Spontaneous hematomas (HP:0007420)2.36432100
50Gastrointestinal inflammation (HP:0004386)2.34953222
51White forelock (HP:0002211)2.34054040
52Glomerulopathy (HP:0100820)2.32969857
53Peritonitis (HP:0002586)2.29566479
54* Absent frontal sinuses (HP:0002688)2.29471040
55Hypergammaglobulinemia (HP:0010702)2.29314230
56IgG deficiency (HP:0004315)2.28249770
57Pulmonary embolism (HP:0002204)2.27844140
58Fatigue (HP:0012378)2.26999436
59Volvulus (HP:0002580)2.26146359
60Keratoconjunctivitis sicca (HP:0001097)2.24641816
61Prolonged bleeding time (HP:0003010)2.24049788
62Thyroiditis (HP:0100646)2.23764682
63Acute lymphatic leukemia (HP:0006721)2.23295681
64Abnormality of T cell physiology (HP:0011840)2.20791113
65Abnormality of the pleura (HP:0002103)2.17502623
66Lip pit (HP:0100267)2.17234683
67Colitis (HP:0002583)2.16277002
68Gangrene (HP:0100758)2.15794462
69Short tibia (HP:0005736)2.15443918
70Recurrent gram-negative bacterial infections (HP:0005420)2.15270088
71Facial diplegia (HP:0001349)2.15243894
72Abnormality of the fingertips (HP:0001211)2.14456336
73Abnormality of the pericardium (HP:0001697)2.13470361
74Recurrent pneumonia (HP:0006532)2.12912079
75* Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.12689590
76Dysostosis multiplex (HP:0000943)2.11572749
77Pulmonary fibrosis (HP:0002206)2.11469043
78Arterial thrombosis (HP:0004420)2.10837881
79Increased IgM level (HP:0003496)2.10744615
80Verrucae (HP:0200043)2.10528404
81Papilloma (HP:0012740)2.10528404
82Recurrent bronchitis (HP:0002837)2.10008071
83Inappropriate behavior (HP:0000719)2.09517556
84Amelogenesis imperfecta (HP:0000705)2.08847909
85Microglossia (HP:0000171)2.08258987
86Mesomelia (HP:0003027)2.07589177
87Viral hepatitis (HP:0006562)2.06372191
88Alveolar cell carcinoma (HP:0006519)2.05729496
89Aortic dissection (HP:0002647)2.05543435
90Interstitial pulmonary disease (HP:0006530)2.05080034
91Limited elbow extension (HP:0001377)2.04977943
92Abnormality of incisor morphology (HP:0011063)2.04702423
93Premature rupture of membranes (HP:0001788)2.04135816
94Neoplasm of the tracheobronchial system (HP:0100552)2.03652111
95Chronic otitis media (HP:0000389)2.03173546
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02445997
97* Decreased skull ossification (HP:0004331)2.01838506
98Slender build (HP:0001533)2.01011050
99Abnormality of liposaccharide metabolism (HP:0010968)2.00239974
100Abnormality of glycosphingolipid metabolism (HP:0004343)2.00239974
101Abnormality of glycolipid metabolism (HP:0010969)2.00239974
102Keratoconjunctivitis (HP:0001096)1.99247763
103Abnormality of the columella (HP:0009929)1.98973001
104Aplasia/Hypoplasia of the tibia (HP:0005772)1.97448710
105Pulmonary infiltrates (HP:0002113)1.96862662
106Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.96283492
107Short 4th metacarpal (HP:0010044)1.96283492
108Abnormality of lateral ventricle (HP:0030047)1.95679290
109Chronic diarrhea (HP:0002028)1.95317887
110Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95073794
111Amyloidosis (HP:0011034)1.94719407
112Vasculitis (HP:0002633)1.93116783
113Recurrent lower respiratory tract infections (HP:0002783)1.91754445
114Agammaglobulinemia (HP:0004432)1.91399181
115Epistaxis (HP:0000421)1.91219142
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.90876980
117Osteolytic defects of the hand bones (HP:0009699)1.90876980
118Skin rash (HP:0000988)1.90185100
119Skin ulcer (HP:0200042)1.89835753
120Biconcave vertebral bodies (HP:0004586)1.89821734
121Abnormality of the nasal septum (HP:0000419)1.89113382
122Petechiae (HP:0000967)1.88831525
123Anorexia (HP:0002039)1.88785456
124* Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88384450
125* Craniofacial hyperostosis (HP:0004493)1.86701331
126Abnormality of male internal genitalia (HP:0000022)1.86410554
127Amaurosis fugax (HP:0100576)1.85855368
128Vertebral compression fractures (HP:0002953)1.85456095
129Stomatitis (HP:0010280)1.85183402
130Abnormality of T cells (HP:0002843)1.83822220
131Gingivitis (HP:0000230)1.82408072
132* Abnormality of skull ossification (HP:0002703)1.81713666
133Abnormal platelet volume (HP:0011876)1.80174668
134Gingival bleeding (HP:0000225)1.76411681
135Hemoptysis (HP:0002105)1.76391559
136Albinism (HP:0001022)1.76064615
137Encephalitis (HP:0002383)1.75065364
138Dislocated radial head (HP:0003083)1.74479808
139Broad face (HP:0000283)1.69772794
140Leukocytosis (HP:0001974)1.68910125
141Abnormality of the right ventricle (HP:0001707)1.67597483
142Abnormality of T cell number (HP:0011839)1.67521670
143T lymphocytopenia (HP:0005403)1.66520478
144Abnormality of B cell number (HP:0010975)1.66230644
145B lymphocytopenia (HP:0010976)1.66230644
146Lower limb hyperreflexia (HP:0002395)1.65493031
147Osteomyelitis (HP:0002754)1.64563811
148Periodontitis (HP:0000704)1.64482301
149Cervical subluxation (HP:0003308)1.63900376
150Abnormal number of erythroid precursors (HP:0012131)1.63277716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1JAK33.44819810
2IRAK43.02895690
3BLK2.96120019
4KIT2.80875662
5MKNK22.65860885
6MAP4K12.60789328
7TXK2.51629693
8MAP3K142.49730159
9IRAK32.48984310
10FLT32.47376060
11BRD42.40453558
12TEC2.24664131
13RIPK42.21026010
14TAOK32.10784308
15CLK12.04274817
16ERN12.03644502
17PRPF4B1.95607070
18MKNK11.94154724
19TNIK1.91532115
20CSF1R1.83917386
21SIK31.81653758
22IKBKB1.66995815
23BTK1.57125338
24FES1.52167903
25MAP3K131.44602113
26STK101.43965828
27EPHA31.34066305
28PIK3CG1.33363961
29TRPM71.22402439
30CDK91.21884475
31SYK1.20159425
32IKBKE1.19536958
33LCK1.18452462
34MAPK71.17547180
35TYK21.17367728
36PIK3CA1.17289390
37CHUK1.14377368
38MAP3K61.13899232
39BMPR21.09776485
40TBK11.02876536
41JAK10.99963231
42JAK20.98800922
43HCK0.98311691
44CSK0.95387464
45SIK20.95184229
46MAP2K30.94746843
47ZAP700.92913346
48GRK70.92912216
49EIF2AK20.90260632
50DYRK1A0.89863737
51LYN0.89425714
52MUSK0.89319585
53MOS0.86526573
54TAOK20.86448543
55EPHB10.86384480
56CDK60.83570331
57MAP3K30.83318487
58MAP3K80.81802916
59NEK90.80624499
60YES10.80621466
61RPS6KA60.79983106
62ITK0.79108260
63MAP3K120.78684812
64MAPK40.78036464
65TESK20.77640441
66ADRBK20.77001601
67MARK30.76201173
68PIM10.75398039
69NUAK10.74669784
70RPS6KC10.74119344
71RPS6KL10.74119344
72FGFR30.73202981
73TGFBR20.71123707
74NLK0.71013347
75PRKCQ0.70281460
76SCYL20.69754247
77MST40.69668889
78MELK0.69079832
79CDK120.69024505
80MAP2K20.67827186
81STK110.67466973
82CASK0.66283832
83RPS6KA40.65316295
84AKT30.65274107
85CDK40.64120344
86HIPK20.63317430
87DMPK0.61006619
88NEK60.58799325
89BMPR1B0.56748757
90SIK10.55539483
91MAP3K50.54397077
92FRK0.53060309
93MAP3K10.52078405
94ERBB30.52052109
95FGR0.51939048
96MAPK110.51406070
97ATR0.49384423
98IRAK10.48901146
99DDR20.47846290
100MATK0.47777851
101MAPKAPK20.47274436
102RPS6KB10.47063908
103CAMK1G0.46113251
104RPS6KA20.44415822
105GRK60.44036647
106PTK2B0.43826892
107PDK10.43618786
108ABL10.43433164
109EIF2AK30.43413009
110CDK80.41498305
111MAP3K70.41362875
112MAPKAPK50.41118883
113SGK30.40810648
114PKN10.40585944
115MAPK120.40297112
116CDK190.39021069
117CDK70.38780216
118PRKD20.38369453
119PDPK10.37957510
120* MAPK30.37813582
121ZAK0.37715039
122IGF1R0.37393761
123MARK20.37175574
124SGK20.37018511
125STK40.36907017
126MAP3K20.36356496
127CAMK1D0.35798488
128RPS6KB20.35416501
129BRSK20.35282349
130TNK20.35124246
131MAP2K60.32719035

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.35986237
2Graft-versus-host disease_Homo sapiens_hsa053322.22186377
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.09391097
4Measles_Homo sapiens_hsa051621.95178724
5Osteoclast differentiation_Homo sapiens_hsa043801.90847659
6Intestinal immune network for IgA production_Homo sapiens_hsa046721.90448300
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.83738542
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.81032023
9Primary immunodeficiency_Homo sapiens_hsa053401.77952423
10Staphylococcus aureus infection_Homo sapiens_hsa051501.77003193
11Hematopoietic cell lineage_Homo sapiens_hsa046401.74647483
12Allograft rejection_Homo sapiens_hsa053301.69917537
13B cell receptor signaling pathway_Homo sapiens_hsa046621.59395620
14Malaria_Homo sapiens_hsa051441.50126158
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47199691
16Platelet activation_Homo sapiens_hsa046111.46152420
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.39999125
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38979745
19* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38659551
20Herpes simplex infection_Homo sapiens_hsa051681.35499608
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33818186
22Tuberculosis_Homo sapiens_hsa051521.32087909
23Chemokine signaling pathway_Homo sapiens_hsa040621.30976759
24T cell receptor signaling pathway_Homo sapiens_hsa046601.28608387
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23913097
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22826887
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22059621
28TNF signaling pathway_Homo sapiens_hsa046681.20736028
29Hepatitis B_Homo sapiens_hsa051611.17592233
30Asthma_Homo sapiens_hsa053101.17506933
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16934131
32Shigellosis_Homo sapiens_hsa051311.14543241
33Toxoplasmosis_Homo sapiens_hsa051451.14233333
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.12071774
35Influenza A_Homo sapiens_hsa051641.12045463
36Autoimmune thyroid disease_Homo sapiens_hsa053201.10452841
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08825809
38Ovarian steroidogenesis_Homo sapiens_hsa049131.08703468
39ECM-receptor interaction_Homo sapiens_hsa045121.07128187
40Acute myeloid leukemia_Homo sapiens_hsa052211.05983414
41Antigen processing and presentation_Homo sapiens_hsa046121.05763316
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02659535
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01577906
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00789783
45Pertussis_Homo sapiens_hsa051330.96173811
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95708519
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.95347109
48African trypanosomiasis_Homo sapiens_hsa051430.94655634
49Pancreatic cancer_Homo sapiens_hsa052120.92200852
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87316348
51Chronic myeloid leukemia_Homo sapiens_hsa052200.85355968
52Non-homologous end-joining_Homo sapiens_hsa034500.84560527
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83949425
54Apoptosis_Homo sapiens_hsa042100.83930739
55Viral myocarditis_Homo sapiens_hsa054160.81961252
56Salmonella infection_Homo sapiens_hsa051320.81289848
57Rheumatoid arthritis_Homo sapiens_hsa053230.80919539
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79360340
59MicroRNAs in cancer_Homo sapiens_hsa052060.78049779
60Small cell lung cancer_Homo sapiens_hsa052220.77362106
61Hepatitis C_Homo sapiens_hsa051600.75761978
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75467941
63p53 signaling pathway_Homo sapiens_hsa041150.74671301
64Other glycan degradation_Homo sapiens_hsa005110.73906233
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72268962
66Focal adhesion_Homo sapiens_hsa045100.70938583
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.70831007
68HTLV-I infection_Homo sapiens_hsa051660.70722495
69VEGF signaling pathway_Homo sapiens_hsa043700.70623788
70Viral carcinogenesis_Homo sapiens_hsa052030.70358352
71Fanconi anemia pathway_Homo sapiens_hsa034600.67799384
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67690120
73RNA degradation_Homo sapiens_hsa030180.66957552
74Prostate cancer_Homo sapiens_hsa052150.66667699
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64875863
76Prolactin signaling pathway_Homo sapiens_hsa049170.64077534
77Phagosome_Homo sapiens_hsa041450.64038927
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62936853
79Sphingolipid metabolism_Homo sapiens_hsa006000.62883676
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61984745
81Morphine addiction_Homo sapiens_hsa050320.61760912
82Pathways in cancer_Homo sapiens_hsa052000.61623594
83Salivary secretion_Homo sapiens_hsa049700.61182940
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60172584
85Wnt signaling pathway_Homo sapiens_hsa043100.59908907
86MAPK signaling pathway_Homo sapiens_hsa040100.59008762
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58345184
88Homologous recombination_Homo sapiens_hsa034400.57978021
89Non-small cell lung cancer_Homo sapiens_hsa052230.57598824
90Epstein-Barr virus infection_Homo sapiens_hsa051690.57144717
91Dorso-ventral axis formation_Homo sapiens_hsa043200.56420910
92Calcium signaling pathway_Homo sapiens_hsa040200.56281974
93Rap1 signaling pathway_Homo sapiens_hsa040150.56255200
94mTOR signaling pathway_Homo sapiens_hsa041500.55666380
95Lysosome_Homo sapiens_hsa041420.55446191
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55284440
97Legionellosis_Homo sapiens_hsa051340.54922844
98Melanoma_Homo sapiens_hsa052180.54498688
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.54200556
100Proteoglycans in cancer_Homo sapiens_hsa052050.54077088
101cAMP signaling pathway_Homo sapiens_hsa040240.52671954
102Oxytocin signaling pathway_Homo sapiens_hsa049210.52509667
103Type I diabetes mellitus_Homo sapiens_hsa049400.51732027
104Long-term potentiation_Homo sapiens_hsa047200.50885284
105Circadian entrainment_Homo sapiens_hsa047130.50838983
106Ribosome_Homo sapiens_hsa030100.50751795
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50687203
108Notch signaling pathway_Homo sapiens_hsa043300.50562958
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50213246
110Amoebiasis_Homo sapiens_hsa051460.49826517
111FoxO signaling pathway_Homo sapiens_hsa040680.49254244
112Renal cell carcinoma_Homo sapiens_hsa052110.48509155
113Systemic lupus erythematosus_Homo sapiens_hsa053220.47694979
114Insulin resistance_Homo sapiens_hsa049310.46159885
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.46151242
116Bladder cancer_Homo sapiens_hsa052190.41724747
117Colorectal cancer_Homo sapiens_hsa052100.41639644
118Endocytosis_Homo sapiens_hsa041440.41254229
119Choline metabolism in cancer_Homo sapiens_hsa052310.41084288
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40794827
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40158607
122Inositol phosphate metabolism_Homo sapiens_hsa005620.36631523
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34844011
124Glioma_Homo sapiens_hsa052140.32744984
125Endometrial cancer_Homo sapiens_hsa052130.29769302
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.25586446

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