RUNX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.11724006
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.11666271
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.11666271
4antigen processing and presentation of endogenous antigen (GO:0019883)5.08341259
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.40761115
6positive regulation by symbiont of host defense response (GO:0052509)4.27402222
7modulation by symbiont of host defense response (GO:0052031)4.27402222
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.27402222
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.27402222
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.27402222
11modulation by symbiont of host immune response (GO:0052553)4.27402222
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.25060564
13response to interleukin-15 (GO:0070672)4.16650940
14negative thymic T cell selection (GO:0045060)4.09452887
15negative regulation of interleukin-12 production (GO:0032695)4.04019016
16negative T cell selection (GO:0043383)4.03589072
17ribosomal small subunit assembly (GO:0000028)3.98483557
18regulation of B cell receptor signaling pathway (GO:0050855)3.94637406
19cellular response to interleukin-15 (GO:0071350)3.92207938
20regulation of gamma-delta T cell differentiation (GO:0045586)3.87536141
21regulation of B cell differentiation (GO:0045577)3.85369116
22positive regulation of B cell differentiation (GO:0045579)3.84915307
23macrophage activation involved in immune response (GO:0002281)3.80003923
24negative regulation of T cell mediated immunity (GO:0002710)3.74862626
25T cell migration (GO:0072678)3.72417458
26negative regulation of phagocytosis (GO:0050765)3.71945071
27* interferon-gamma production (GO:0032609)3.66998581
28regulation of isotype switching to IgG isotypes (GO:0048302)3.66224823
29positive thymic T cell selection (GO:0045059)3.65724731
30regulation of gamma-delta T cell activation (GO:0046643)3.65445474
31leukocyte aggregation (GO:0070486)3.64170537
32regulation of interleukin-2 biosynthetic process (GO:0045076)3.61576713
33detection of bacterium (GO:0016045)3.59292529
34regulation of T cell tolerance induction (GO:0002664)3.57669849
35mast cell activation (GO:0045576)3.56918125
36NIK/NF-kappaB signaling (GO:0038061)3.53801106
37detection of other organism (GO:0098543)3.53443590
38myeloid dendritic cell activation (GO:0001773)3.52914508
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49877758
40negative regulation of cell killing (GO:0031342)3.49877758
41response to peptidoglycan (GO:0032494)3.47044691
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.43535482
43Arp2/3 complex-mediated actin nucleation (GO:0034314)3.41478423
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.40720693
45activated T cell proliferation (GO:0050798)3.39539238
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.39004430
47thymic T cell selection (GO:0045061)3.38897924
48T cell homeostasis (GO:0043029)3.38109457
49regulation of interferon-beta biosynthetic process (GO:0045357)3.33417346
50tolerance induction (GO:0002507)3.33349523
51regulation of T cell receptor signaling pathway (GO:0050856)3.29512878
52myeloid dendritic cell differentiation (GO:0043011)3.28402933
53B cell receptor signaling pathway (GO:0050853)3.26472127
54regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.24059987
55positive regulation of isotype switching (GO:0045830)3.22530251
56germinal center formation (GO:0002467)3.22291373
57regulation of dendritic cell antigen processing and presentation (GO:0002604)3.20504522
58antigen processing and presentation via MHC class Ib (GO:0002475)3.17117060
59regulation of tolerance induction (GO:0002643)3.17047079
60regulation of alpha-beta T cell proliferation (GO:0046640)3.15810582
61immunoglobulin mediated immune response (GO:0016064)3.15092479
62negative regulation of leukocyte mediated immunity (GO:0002704)3.14995540
63B cell homeostasis (GO:0001782)3.10773413
64natural killer cell activation (GO:0030101)3.10273546
65T cell selection (GO:0045058)3.09468011
66response to protozoan (GO:0001562)3.09207939
67regulation of interferon-alpha production (GO:0032647)3.08527334
68megakaryocyte development (GO:0035855)3.07651781
69defense response to protozoan (GO:0042832)3.06003053
70regulation of antigen processing and presentation (GO:0002577)3.05664268
71myeloid cell activation involved in immune response (GO:0002275)3.05353774
72positive regulation of interferon-alpha production (GO:0032727)3.04205773
73positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.02809034
74regulation of T cell mediated cytotoxicity (GO:0001914)3.01770063
75positive regulation of B cell activation (GO:0050871)3.01353894
76positive regulation of granulocyte differentiation (GO:0030854)3.01025418
77response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.99218160
78response to host immune response (GO:0052572)2.99218160
79lymphocyte migration (GO:0072676)2.98881245
80neutrophil activation involved in immune response (GO:0002283)2.98609577
81positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97350064
82regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.97328670
83positive regulation of interleukin-2 production (GO:0032743)2.97246131
84positive T cell selection (GO:0043368)2.96777473
85negative regulation of cytokine production involved in immune response (GO:0002719)2.96701033
86regulation of hypersensitivity (GO:0002883)2.96187942
87regulation of type I interferon-mediated signaling pathway (GO:0060338)2.95380552
88response to type I interferon (GO:0034340)2.95037410
89regulation of isotype switching (GO:0045191)2.93598112
90type I interferon signaling pathway (GO:0060337)2.92731955
91cellular response to type I interferon (GO:0071357)2.92731955
92mast cell activation involved in immune response (GO:0002279)2.91797820
93mast cell degranulation (GO:0043303)2.91797820
94neutrophil activation (GO:0042119)2.91721956
95negative regulation of innate immune response (GO:0045824)2.90866848
96lymph node development (GO:0048535)2.90545270
97regulation of leukocyte mediated cytotoxicity (GO:0001910)2.89163268
98lymphocyte homeostasis (GO:0002260)2.89006605
99positive regulation of DNA recombination (GO:0045911)2.85511814
100mature B cell differentiation (GO:0002335)2.84597514
101positive regulation of antigen processing and presentation (GO:0002579)2.83329851
102viral transcription (GO:0019083)2.83241672
103regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.81301372
104negative regulation of erythrocyte differentiation (GO:0045647)2.80517856
105antigen receptor-mediated signaling pathway (GO:0050851)2.80317674
106positive regulation of defense response to virus by host (GO:0002230)2.78869661
107interferon-gamma-mediated signaling pathway (GO:0060333)2.77942676
108regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77037437
109positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.76365899
110tyrosine phosphorylation of STAT protein (GO:0007260)2.76015441
111CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.74525891
112regulation of protein heterodimerization activity (GO:0043497)2.73994746
113negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.73251863
114T cell costimulation (GO:0031295)2.72759077
115regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.72574510
116positive regulation of B cell mediated immunity (GO:0002714)2.72250622
117positive regulation of immunoglobulin mediated immune response (GO:0002891)2.72250622
118positive regulation of macrophage differentiation (GO:0045651)2.71462375
119actin nucleation (GO:0045010)2.71336486
120regulation of response to interferon-gamma (GO:0060330)2.71089199
121positive regulation of natural killer cell differentiation (GO:0032825)2.70719571
122cellular response to zinc ion (GO:0071294)2.69702922
123regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.69510915
124regulation of natural killer cell mediated immunity (GO:0002715)2.69510915
125regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.68923787
126alpha-beta T cell activation (GO:0046631)2.68788505
127regulation of T-helper 1 cell differentiation (GO:0045625)2.68467155
128dendritic cell chemotaxis (GO:0002407)2.68346003
129definitive hemopoiesis (GO:0060216)2.68198719
130lymphocyte costimulation (GO:0031294)2.68051795
131B cell mediated immunity (GO:0019724)2.67784687
132granulocyte activation (GO:0036230)2.67491577
133translational termination (GO:0006415)2.67416269
134positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.67367811
135T cell receptor signaling pathway (GO:0050852)2.67339781
136cellular extravasation (GO:0045123)2.66857664
137JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.65327768
138response to muramyl dipeptide (GO:0032495)2.63796448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.28126187
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.54142917
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.30740009
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.28063320
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.67533716
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.64317751
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44111283
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.26555738
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.19707323
10MYC_22102868_ChIP-Seq_BL_Human3.10055104
11SCL_19346495_ChIP-Seq_HPC-7_Human3.04173686
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.00007156
13* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.90354596
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82632230
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73961232
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.69564638
17VDR_21846776_ChIP-Seq_THP-1_Human2.65245005
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63013490
19* MYB_26560356_Chip-Seq_TH2_Human2.61632666
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.57212932
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.40812665
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38684478
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.36171824
24SPI1_23547873_ChIP-Seq_NB4_Human2.33488939
25* MAF_26560356_Chip-Seq_TH1_Human2.31299236
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30843278
27RUNX_20019798_ChIP-Seq_JUKART_Human2.28438548
28* MYB_26560356_Chip-Seq_TH1_Human2.28347777
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23915714
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13000872
31* NOTCH1_21737748_ChIP-Seq_TLL_Human2.10595700
32VDR_24763502_ChIP-Seq_THP-1_Human2.10462434
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.05211169
34* RUNX1_22412390_ChIP-Seq_EML_Mouse2.02897965
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.01660858
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98574428
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97680724
38UTX_26944678_Chip-Seq_JUKART_Human1.97026678
39* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91487995
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87489812
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78864215
42* TCF7_22412390_ChIP-Seq_EML_Mouse1.76677338
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.71295886
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69184342
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58517208
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56661278
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55950267
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53353931
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51090540
50* VDR_23849224_ChIP-Seq_CD4+_Human1.50180297
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49891373
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49812961
53* MAF_26560356_Chip-Seq_TH2_Human1.49768973
54CIITA_25753668_ChIP-Seq_RAJI_Human1.49418221
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48850200
56VDR_24787735_ChIP-Seq_THP-1_Human1.47018122
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45553675
58* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45282310
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42942556
60SPI1_23127762_ChIP-Seq_K562_Human1.41210017
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40552966
62* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38336564
63MYC_18555785_ChIP-Seq_MESCs_Mouse1.36076596
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34098378
65FOXP3_21729870_ChIP-Seq_TREG_Human1.33659698
66PU_27001747_Chip-Seq_BMDM_Mouse1.33368304
67* GATA3_27048872_Chip-Seq_THYMUS_Human1.33279184
68LXR_22292898_ChIP-Seq_THP-1_Human1.26100266
69* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24053000
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23967847
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23590323
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22104050
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21705214
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20127561
75* KDM2B_26808549_Chip-Seq_JURKAT_Human1.17624237
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.15537444
77* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15459771
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.14608042
79GATA1_22025678_ChIP-Seq_K562_Human1.12768895
80* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12376765
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11858397
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.10284563
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10222004
84* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09995343
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.07448892
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07223889
87* GATA3_26560356_Chip-Seq_TH2_Human1.06345938
88ELK1_19687146_ChIP-ChIP_HELA_Human1.01871672
89BCL6_27268052_Chip-Seq_Bcells_Human1.01791739
90* GATA1_19941827_ChIP-Seq_MEL_Mouse1.01297558
91TP63_19390658_ChIP-ChIP_HaCaT_Human0.99388670
92* KDM2B_26808549_Chip-Seq_DND41_Human0.99249626
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99213923
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97693285
95MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96310711
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96201865
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.94190276
98XRN2_22483619_ChIP-Seq_HELA_Human0.93971305
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93871350
100BCOR_27268052_Chip-Seq_Bcells_Human0.92573232
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92284138
102GATA1_19941826_ChIP-Seq_K562_Human0.91952742
103MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91682494
104NCOR1_26117541_ChIP-Seq_K562_Human0.89831128
105NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89652074
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89328137
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87494679
108MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86782062
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86308651
110* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86114664
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85620548
112* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85397235
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84860086
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.83846135
115* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83715551
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82948695
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81778636
118DCP1A_22483619_ChIP-Seq_HELA_Human0.79207125
119ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78358082
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77954075
121* SA1_27219007_Chip-Seq_ERYTHROID_Human0.77307831
122* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75405125
123* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75108220
124* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74992668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.36861010
2MP0005671_abnormal_response_to3.84277402
3MP0000685_abnormal_immune_system3.40595572
4MP0003763_abnormal_thymus_physiology3.40535833
5MP0002396_abnormal_hematopoietic_system3.19029140
6* MP0001800_abnormal_humoral_immune3.10465307
7MP0001790_abnormal_immune_system3.07004346
8MP0005387_immune_system_phenotype3.07004346
9MP0005000_abnormal_immune_tolerance2.92519342
10MP0009785_altered_susceptibility_to2.89365005
11MP0003436_decreased_susceptibility_to2.75445892
12* MP0002452_abnormal_antigen_presenting2.70056780
13* MP0002723_abnormal_immune_serum2.69684437
14* MP0002420_abnormal_adaptive_immunity2.67147246
15MP0005025_abnormal_response_to2.65256907
16* MP0001819_abnormal_immune_cell2.65092475
17* MP0002398_abnormal_bone_marrow2.59811042
18MP0002148_abnormal_hypersensitivity_rea2.57911159
19MP0009333_abnormal_splenocyte_physiolog2.38678575
20MP0002419_abnormal_innate_immunity2.33074779
21* MP0000716_abnormal_immune_system2.29417749
22MP0002166_altered_tumor_susceptibility2.20772142
23MP0003303_peritoneal_inflammation2.17815351
24* MP0002405_respiratory_system_inflammati2.16555997
25MP0004808_abnormal_hematopoietic_stem2.14066413
26MP0008057_abnormal_DNA_replication2.12650331
27* MP0002722_abnormal_immune_system2.07486015
28MP0000689_abnormal_spleen_morphology2.07417529
29MP0005464_abnormal_platelet_physiology1.97364551
30MP0000703_abnormal_thymus_morphology1.96990583
31MP0002006_tumorigenesis1.96229824
32MP0001853_heart_inflammation1.95762011
33MP0001545_abnormal_hematopoietic_system1.94758741
34MP0005397_hematopoietic_system_phenotyp1.94758741
35MP0003724_increased_susceptibility_to1.94532503
36* MP0002429_abnormal_blood_cell1.94389306
37* MP0010155_abnormal_intestine_physiology1.90089667
38MP0004510_myositis1.84889061
39MP0006082_CNS_inflammation1.79007882
40MP0003866_abnormal_defecation1.76689542
41MP0005174_abnormal_tail_pigmentation1.69306113
42* MP0001845_abnormal_inflammatory_respons1.66624945
43MP0003300_gastrointestinal_ulcer1.66576225
44* MP0000490_abnormal_crypts_of1.65880388
45MP0005075_abnormal_melanosome_morpholog1.63200626
46MP0000465_gastrointestinal_hemorrhage1.62193284
47MP0005310_abnormal_salivary_gland1.59746578
48* MP0001873_stomach_inflammation1.57986391
49MP0005451_abnormal_body_composition1.54130100
50MP0009278_abnormal_bone_marrow1.44248091
51MP0000858_altered_metastatic_potential1.42597349
52MP0004947_skin_inflammation1.41818613
53MP0010094_abnormal_chromosome_stability1.37135545
54MP0002933_joint_inflammation1.33414176
55MP0001533_abnormal_skeleton_physiology1.28479069
56MP0003693_abnormal_embryo_hatching1.26244471
57MP0010307_abnormal_tumor_latency1.24153048
58MP0003448_altered_tumor_morphology1.22316684
59MP0002138_abnormal_hepatobiliary_system1.22010333
60MP0002132_abnormal_respiratory_system1.18732451
61MP0003077_abnormal_cell_cycle1.15679530
62MP0002019_abnormal_tumor_incidence1.15551217
63MP0005058_abnormal_lysosome_morphology1.15366720
64* MP0008469_abnormal_protein_level1.14177081
65MP0008007_abnormal_cellular_replicative1.08823036
66MP0010352_gastrointestinal_tract_polyps1.04170538
67MP0001348_abnormal_lacrimal_gland0.97544851
68MP0008058_abnormal_DNA_repair0.96186132
69MP0002095_abnormal_skin_pigmentation0.95401451
70MP0003111_abnormal_nucleus_morphology0.93829446
71MP0002009_preneoplasia0.89600282
72MP0005166_decreased_susceptibility_to0.88426741
73MP0002998_abnormal_bone_remodeling0.87934386
74MP0000015_abnormal_ear_pigmentation0.86690110
75MP0003075_altered_response_to0.86209761
76MP0009840_abnormal_foam_cell0.82320183
77MP0009764_decreased_sensitivity_to0.80340788
78MP0000343_altered_response_to0.79170038
79MP0003045_fibrosis0.77861454
80MP0001851_eye_inflammation0.77451979
81MP0002163_abnormal_gland_morphology0.77043578
82MP0005076_abnormal_cell_differentiation0.74968203
83MP0002877_abnormal_melanocyte_morpholog0.73898672
84MP0004957_abnormal_blastocyst_morpholog0.73657001
85MP0008260_abnormal_autophagy0.73159472
86MP0003191_abnormal_cellular_cholesterol0.72450309
87MP0002254_reproductive_system_inflammat0.70854907
88MP0004381_abnormal_hair_follicle0.68563033
89MP0009763_increased_sensitivity_to0.68154120
90MP0000313_abnormal_cell_death0.67522420
91MP0003943_abnormal_hepatobiliary_system0.66995320
92MP0003690_abnormal_glial_cell0.66884909
93* MP0001663_abnormal_digestive_system0.65288054
94MP0003453_abnormal_keratinocyte_physiol0.65278584
95MP0002277_abnormal_respiratory_mucosa0.65125040
96MP0000604_amyloidosis0.65057811
97MP0003091_abnormal_cell_migration0.64233076
98MP0004883_abnormal_blood_vessel0.62894743
99MP0002693_abnormal_pancreas_physiology0.62842623
100MP0005390_skeleton_phenotype0.61548147
101MP0008961_abnormal_basal_metabolism0.58228996
102MP0000371_diluted_coat_color0.57016877
103MP0003172_abnormal_lysosome_physiology0.56595796
104MP0003795_abnormal_bone_structure0.56532617
105MP0008874_decreased_physiological_sensi0.53449232
106MP0003786_premature_aging0.52920462
107MP0001986_abnormal_taste_sensitivity0.51043761
108MP0003183_abnormal_peptide_metabolism0.49922667
109MP0008004_abnormal_stomach_pH0.49591722
110* MP0000477_abnormal_intestine_morphology0.49172014
111MP0000609_abnormal_liver_physiology0.48904532
112MP0000350_abnormal_cell_proliferation0.48273488
113MP0003656_abnormal_erythrocyte_physiolo0.47305115
114MP0005164_abnormal_response_to0.45765669
115MP0000249_abnormal_blood_vessel0.45666560
116MP0009765_abnormal_xenobiotic_induced0.45443393
117MP0008873_increased_physiological_sensi0.45249271
118MP0006054_spinal_hemorrhage0.45233135
119MP0002332_abnormal_exercise_endurance0.45085078
120MP0003828_pulmonary_edema0.43954638
121MP0008995_early_reproductive_senescence0.41838180
122MP0001881_abnormal_mammary_gland0.41565235

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)4.92729302
2IgM deficiency (HP:0002850)4.77017927
3Chronic otitis media (HP:0000389)4.47286947
4Elevated erythrocyte sedimentation rate (HP:0003565)4.46631081
5Recurrent abscess formation (HP:0002722)4.27854307
6Eczematoid dermatitis (HP:0000976)4.19878599
7Optic neuritis (HP:0100653)4.16941503
8Retrobulbar optic neuritis (HP:0100654)4.16941503
9Recurrent fungal infections (HP:0002841)4.15340927
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.10352944
11Meningitis (HP:0001287)3.88664025
12Recurrent viral infections (HP:0004429)3.88595868
13Orchitis (HP:0100796)3.87639095
14Recurrent bacterial skin infections (HP:0005406)3.86053469
15Increased IgM level (HP:0003496)3.79798020
16Thrombocytosis (HP:0001894)3.67581497
17T lymphocytopenia (HP:0005403)3.65891677
18Recurrent cutaneous fungal infections (HP:0011370)3.63573665
19Chronic mucocutaneous candidiasis (HP:0002728)3.63573665
20Abnormality of T cell number (HP:0011839)3.61970267
21Panhypogammaglobulinemia (HP:0003139)3.58607643
22Abnormality of T cells (HP:0002843)3.56139779
23Petechiae (HP:0000967)3.53967103
24Recurrent bronchitis (HP:0002837)3.53949834
25Mediastinal lymphadenopathy (HP:0100721)3.48814857
26Nasal polyposis (HP:0100582)3.34747820
27Vasculitis (HP:0002633)3.33385989
28Abnormality of T cell physiology (HP:0011840)3.33027259
29Encephalitis (HP:0002383)3.31409548
30Abnormality of the fingertips (HP:0001211)3.30428129
31Obstructive lung disease (HP:0006536)3.26812870
32Chronic obstructive pulmonary disease (HP:0006510)3.26812870
33Agammaglobulinemia (HP:0004432)3.14748758
34Prolonged bleeding time (HP:0003010)3.13662905
35Recurrent skin infections (HP:0001581)3.10974125
36Cellulitis (HP:0100658)3.04130379
37Inflammation of the large intestine (HP:0002037)3.03876949
38Gastrointestinal inflammation (HP:0004386)2.96461385
39IgG deficiency (HP:0004315)2.86225083
40Pulmonary infiltrates (HP:0002113)2.85063186
41Keratoconjunctivitis sicca (HP:0001097)2.82689843
42Spontaneous hematomas (HP:0007420)2.82627071
43Urticaria (HP:0001025)2.81450319
44Lymphopenia (HP:0001888)2.80357493
45Abnormality of the nasal mucosa (HP:0000433)2.79694788
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.76858770
47Hemoptysis (HP:0002105)2.76767744
48Abnormal number of erythroid precursors (HP:0012131)2.76647862
49Gastrointestinal infarctions (HP:0005244)2.76285722
50Abnormality of the prostate (HP:0008775)2.72457439
51Keratoconjunctivitis (HP:0001096)2.71338411
52Stomatitis (HP:0010280)2.70314103
53Arterial thrombosis (HP:0004420)2.65075678
54Abnormality of cells of the erythroid lineage (HP:0012130)2.64808692
55Abnormality of macrophages (HP:0004311)2.63745977
56Lymphoma (HP:0002665)2.63495052
57Increased IgE level (HP:0003212)2.60367600
58Papilloma (HP:0012740)2.59718610
59Verrucae (HP:0200043)2.59718610
60Reticulocytopenia (HP:0001896)2.58279124
61Abnormality of glycolipid metabolism (HP:0010969)2.54652245
62Abnormality of liposaccharide metabolism (HP:0010968)2.54652245
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.54652245
64Epistaxis (HP:0000421)2.51637936
65Abnormality of B cell number (HP:0010975)2.50110215
66B lymphocytopenia (HP:0010976)2.50110215
67Thyroiditis (HP:0100646)2.49778482
68Gastrointestinal stroma tumor (HP:0100723)2.49742988
69Severe combined immunodeficiency (HP:0004430)2.47499891
70Abnormality of eosinophils (HP:0001879)2.45825537
71Chest pain (HP:0100749)2.44366355
72Autoimmune thrombocytopenia (HP:0001973)2.44317736
73Chronic diarrhea (HP:0002028)2.43050715
74Gangrene (HP:0100758)2.42861332
75Eosinophilia (HP:0001880)2.40695281
76IgA deficiency (HP:0002720)2.40488279
77Leukocytosis (HP:0001974)2.39827736
78Pustule (HP:0200039)2.37833361
79Emphysema (HP:0002097)2.37359537
80Restrictive lung disease (HP:0002091)2.35781566
81Fatigue (HP:0012378)2.34973497
82Granulocytopenia (HP:0001913)2.34945526
83Anorexia (HP:0002039)2.32780732
84Gingival bleeding (HP:0000225)2.31582997
85Colitis (HP:0002583)2.27954080
86Aplastic anemia (HP:0001915)2.26403430
87Impaired platelet aggregation (HP:0003540)2.25746167
88Abnormal platelet function (HP:0011869)2.25746167
89Acute myeloid leukemia (HP:0004808)2.24578758
90Combined immunodeficiency (HP:0005387)2.22243668
91Recurrent sinusitis (HP:0011108)2.19077469
92Periodontitis (HP:0000704)2.16528705
93Hypergammaglobulinemia (HP:0010702)2.16374269
94Chronic sinusitis (HP:0011109)2.16186828
95Abnormal platelet volume (HP:0011876)2.14433779
96Increased serum ferritin (HP:0003281)2.12570256
97Hypochromic anemia (HP:0001931)2.12524356
98Recurrent gram-negative bacterial infections (HP:0005420)2.11736748
99Interstitial pulmonary disease (HP:0006530)2.11120501
100Recurrent pneumonia (HP:0006532)2.10658098
101Dysostosis multiplex (HP:0000943)2.09682445
102Loss of speech (HP:0002371)2.08797973
103Sepsis (HP:0100806)2.08570460
104Recurrent lower respiratory tract infections (HP:0002783)2.07972378
105Increased cerebral lipofuscin (HP:0011813)2.07117641
106Polyneuropathy (HP:0001271)2.07021249
107Increased density of long bones (HP:0006392)2.06349501
108Osteomyelitis (HP:0002754)2.05318856
109Abnormality of the pleura (HP:0002103)2.03935409
110Slow saccadic eye movements (HP:0000514)2.01127835
111Viral hepatitis (HP:0006562)2.00644163
112Gingivitis (HP:0000230)2.00393093
113Glomerulopathy (HP:0100820)2.00046089
114Joint swelling (HP:0001386)1.99464163
115Amaurosis fugax (HP:0100576)1.98353092
116Reduced antithrombin III activity (HP:0001976)1.98335457
117Skin ulcer (HP:0200042)1.93144364
118Pulmonary embolism (HP:0002204)1.92510711
119Autoimmune hemolytic anemia (HP:0001890)1.92090525
120Leukopenia (HP:0001882)1.91928152
121Acute lymphatic leukemia (HP:0006721)1.91853974
122Arthralgia (HP:0002829)1.91085923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.03950614
2TXK4.10512407
3PRPF4B3.87402637
4MAP3K142.70436274
5KIT2.63610002
6JAK32.60428265
7TEC2.29542643
8IRAK42.28255831
9EEF2K2.28018547
10BTK2.27194927
11BLK2.24385957
12TYK22.14682533
13ZAP702.01700950
14PIM21.94416176
15IRAK31.90983718
16IKBKE1.90909927
17TBK11.90640931
18IKBKB1.85323748
19ITK1.79744491
20SYK1.76918459
21TAOK31.76646782
22JAK11.76181831
23NLK1.68153915
24STK101.67174244
25CSF1R1.63204144
26NME21.57624136
27CLK11.56940197
28GRK61.50457731
29LCK1.36981368
30CHUK1.36770891
31FES1.29906715
32SIK31.29890727
33TAOK21.28792439
34BMPR21.27886030
35HCK1.23288580
36* PIM11.21790198
37FLT31.19097168
38MAP3K101.18673840
39FGR1.11136117
40TNK21.10521033
41LYN1.07920245
42TAOK11.07636454
43SIK21.06760541
44MAP3K31.04098948
45LRRK21.03463272
46SMG11.03401550
47MAP2K31.00949644
48GRK71.00842696
49STK240.99423962
50RPS6KA40.97750358
51TRIB30.96494179
52FGFR30.96016336
53CSK0.95524819
54EPHB10.94521423
55CDK120.94488473
56FGFR40.88409128
57MST40.88093611
58CDC42BPA0.87013231
59MAP3K130.84336369
60MAPK70.83940601
61CDC70.82579259
62EIF2AK30.81985638
63TSSK60.80878703
64STK160.80711065
65TESK20.79483857
66NEK20.78657032
67MAP3K10.77823040
68RIPK40.76480289
69JAK20.76445707
70PDK10.75795746
71CDK70.71204153
72MARK30.67170545
73TGFBR20.66820391
74ATR0.66351431
75STK40.65962430
76VRK10.65950241
77MATK0.65846436
78PRKCQ0.65553214
79MAPK120.64353700
80KDR0.64348451
81EPHA30.64098685
82TRPM70.63461438
83TGFBR10.62902157
84MAPK110.62379259
85SIK10.62311454
86TNIK0.61299303
87CAMKK10.60701230
88PRKD20.60178788
89RPS6KB20.57951555
90EIF2AK20.55669487
91MAPK40.55053314
92CDK80.53457199
93NEK90.52595434
94RPS6KA60.52498816
95MKNK20.51397574
96HIPK20.50979431
97PRKCH0.50906975
98CAMKK20.47987107
99SCYL20.47667635
100MKNK10.46591123
101MARK20.46513358
102IRAK10.46499197
103MOS0.45996799
104IRAK20.44728474
105FYN0.43794550
106ACVR1B0.42795496
107TYRO30.42236456
108MAPKAPK20.41747870
109BRD40.39958800
110MAP3K120.39909520
111* CDK40.39852798
112ADRBK20.39845543
113RPS6KC10.39116453
114RPS6KL10.39116453
115MAP2K60.38889414
116MAP3K110.38809257
117MELK0.38632648
118WEE10.37970688
119ERN10.37530222
120PDPK10.37516051
121RPS6KA50.36878390
122MAP3K70.35802905
123EIF2AK10.35589644
124ALK0.35292173
125CDK90.34914144
126PASK0.34416055
127CDK60.33871505
128PIK3CG0.33104322
129ABL10.32312339
130NUAK10.32311429
131YES10.31903426
132MAP3K80.31567284
133MAP3K50.28898789
134KSR20.28401871
135INSR0.27382926

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.33972893
2Graft-versus-host disease_Homo sapiens_hsa053323.03619227
3Allograft rejection_Homo sapiens_hsa053302.74525801
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.71821695
5DNA replication_Homo sapiens_hsa030302.65992107
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.52936499
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.40784617
8Antigen processing and presentation_Homo sapiens_hsa046122.37892141
9Measles_Homo sapiens_hsa051622.37414453
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.32497836
11Leishmaniasis_Homo sapiens_hsa051402.26289020
12B cell receptor signaling pathway_Homo sapiens_hsa046622.02549064
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01192499
14Ribosome_Homo sapiens_hsa030101.99232011
15Osteoclast differentiation_Homo sapiens_hsa043801.91169082
16Hematopoietic cell lineage_Homo sapiens_hsa046401.90822765
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.86886874
18T cell receptor signaling pathway_Homo sapiens_hsa046601.82052889
19Herpes simplex infection_Homo sapiens_hsa051681.77146183
20Autoimmune thyroid disease_Homo sapiens_hsa053201.77138968
21Base excision repair_Homo sapiens_hsa034101.71581287
22Mismatch repair_Homo sapiens_hsa034301.65956290
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63300481
24Homologous recombination_Homo sapiens_hsa034401.53069697
25Acute myeloid leukemia_Homo sapiens_hsa052211.48049983
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48021485
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44589504
28Toxoplasmosis_Homo sapiens_hsa051451.37959924
29Type I diabetes mellitus_Homo sapiens_hsa049401.37116781
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33961167
31Apoptosis_Homo sapiens_hsa042101.33131102
32Viral myocarditis_Homo sapiens_hsa054161.31449385
33Asthma_Homo sapiens_hsa053101.30162599
34Influenza A_Homo sapiens_hsa051641.29640311
35Hepatitis B_Homo sapiens_hsa051611.28693629
36Chemokine signaling pathway_Homo sapiens_hsa040621.19492194
37Shigellosis_Homo sapiens_hsa051311.18535793
38Spliceosome_Homo sapiens_hsa030401.17835175
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15415230
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15285591
41Legionellosis_Homo sapiens_hsa051341.14856360
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13603422
43TNF signaling pathway_Homo sapiens_hsa046681.13360451
44Epstein-Barr virus infection_Homo sapiens_hsa051691.10597044
45Non-homologous end-joining_Homo sapiens_hsa034501.07728453
46Tuberculosis_Homo sapiens_hsa051521.06857280
47Chronic myeloid leukemia_Homo sapiens_hsa052201.03524673
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03220402
49Pertussis_Homo sapiens_hsa051330.99752104
50Nucleotide excision repair_Homo sapiens_hsa034200.97226923
51Malaria_Homo sapiens_hsa051440.96367727
52HTLV-I infection_Homo sapiens_hsa051660.95307251
53Fanconi anemia pathway_Homo sapiens_hsa034600.93502433
54p53 signaling pathway_Homo sapiens_hsa041150.90067408
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89722964
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.88704049
57Platelet activation_Homo sapiens_hsa046110.88118478
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87586133
59Viral carcinogenesis_Homo sapiens_hsa052030.85192062
60Cell cycle_Homo sapiens_hsa041100.84712596
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83496999
62Pancreatic cancer_Homo sapiens_hsa052120.81357602
63Phagosome_Homo sapiens_hsa041450.78490716
64Pyrimidine metabolism_Homo sapiens_hsa002400.76715074
65Salmonella infection_Homo sapiens_hsa051320.76275893
66RNA degradation_Homo sapiens_hsa030180.74117074
67Small cell lung cancer_Homo sapiens_hsa052220.73965997
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72823909
69RNA polymerase_Homo sapiens_hsa030200.70785152
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68357317
71One carbon pool by folate_Homo sapiens_hsa006700.67674198
72Other glycan degradation_Homo sapiens_hsa005110.65613509
73Prolactin signaling pathway_Homo sapiens_hsa049170.64883837
74Lysosome_Homo sapiens_hsa041420.64491969
75Hepatitis C_Homo sapiens_hsa051600.63466464
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.62498901
77Non-small cell lung cancer_Homo sapiens_hsa052230.58541642
78Staphylococcus aureus infection_Homo sapiens_hsa051500.57761713
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57155631
80Colorectal cancer_Homo sapiens_hsa052100.54423131
81RNA transport_Homo sapiens_hsa030130.54150282
82Renal cell carcinoma_Homo sapiens_hsa052110.53791114
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.53141451
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51805790
85Proteasome_Homo sapiens_hsa030500.50182201
86Rheumatoid arthritis_Homo sapiens_hsa053230.49366054
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47898938
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.47162442
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45748305
90Notch signaling pathway_Homo sapiens_hsa043300.42217077
91Basal transcription factors_Homo sapiens_hsa030220.42199097
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40471008
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37635887
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37132467
95N-Glycan biosynthesis_Homo sapiens_hsa005100.36731889
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.36503941
97Protein export_Homo sapiens_hsa030600.36363531
98MicroRNAs in cancer_Homo sapiens_hsa052060.35784482
99African trypanosomiasis_Homo sapiens_hsa051430.35355479
100Endocytosis_Homo sapiens_hsa041440.34450523
101HIF-1 signaling pathway_Homo sapiens_hsa040660.34195829
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33514127
103mTOR signaling pathway_Homo sapiens_hsa041500.32701478
104Pathways in cancer_Homo sapiens_hsa052000.32625910
105Thyroid cancer_Homo sapiens_hsa052160.32574520
106mRNA surveillance pathway_Homo sapiens_hsa030150.32250868
107Insulin resistance_Homo sapiens_hsa049310.31526652
108Dorso-ventral axis formation_Homo sapiens_hsa043200.30717698
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29624479
110Type II diabetes mellitus_Homo sapiens_hsa049300.29330062
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29288879
112VEGF signaling pathway_Homo sapiens_hsa043700.28942979
113Choline metabolism in cancer_Homo sapiens_hsa052310.28141263
114Prostate cancer_Homo sapiens_hsa052150.28042761
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27489440
116FoxO signaling pathway_Homo sapiens_hsa040680.26791904
117Systemic lupus erythematosus_Homo sapiens_hsa053220.26220172
118Endometrial cancer_Homo sapiens_hsa052130.25055992
119GnRH signaling pathway_Homo sapiens_hsa049120.24974560
120MAPK signaling pathway_Homo sapiens_hsa040100.24715564
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.22204507
122Inositol phosphate metabolism_Homo sapiens_hsa005620.20644877
123Bladder cancer_Homo sapiens_hsa052190.20582532
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18563363
125Prion diseases_Homo sapiens_hsa050200.18275060
126Amoebiasis_Homo sapiens_hsa051460.17909324
127ErbB signaling pathway_Homo sapiens_hsa040120.16141695
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15648568
129Ras signaling pathway_Homo sapiens_hsa040140.12472287

Most similar genes based on co-expression Upload to Enrichr

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