RUSC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.33800078
2synaptic vesicle maturation (GO:0016188)6.11950865
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.67067677
4synaptic vesicle exocytosis (GO:0016079)5.60645493
5vocalization behavior (GO:0071625)5.56116405
6glutamate secretion (GO:0014047)5.44933303
7locomotory exploration behavior (GO:0035641)5.42427550
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.38959200
9regulation of synaptic vesicle exocytosis (GO:2000300)5.34419075
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.17760599
11protein localization to synapse (GO:0035418)4.88719116
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.79609863
13regulation of glutamate receptor signaling pathway (GO:1900449)4.79295853
14neuronal action potential propagation (GO:0019227)4.78599935
15regulation of synaptic vesicle transport (GO:1902803)4.77442291
16neuron cell-cell adhesion (GO:0007158)4.76997293
17neurotransmitter secretion (GO:0007269)4.69144038
18layer formation in cerebral cortex (GO:0021819)4.51172250
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.46380382
20exploration behavior (GO:0035640)4.44835747
21response to pheromone (GO:0019236)4.35987484
22regulation of neuronal synaptic plasticity (GO:0048168)4.34676873
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.32698611
24regulation of synapse structural plasticity (GO:0051823)4.30635768
25proline transport (GO:0015824)4.17160521
26synaptic transmission, glutamatergic (GO:0035249)4.00051508
27activation of protein kinase A activity (GO:0034199)3.98656326
28gamma-aminobutyric acid transport (GO:0015812)3.98383158
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95804191
30dendritic spine morphogenesis (GO:0060997)3.91336000
31glutamate receptor signaling pathway (GO:0007215)3.87629620
32neuron-neuron synaptic transmission (GO:0007270)3.77668183
33long-term memory (GO:0007616)3.74858287
34neurotransmitter transport (GO:0006836)3.73433357
35positive regulation of membrane potential (GO:0045838)3.69661666
36cellular potassium ion homeostasis (GO:0030007)3.67406357
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.66309954
38positive regulation of synapse maturation (GO:0090129)3.64027419
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63607050
40neuron recognition (GO:0008038)3.58503492
41synaptic vesicle endocytosis (GO:0048488)3.56709170
42regulation of postsynaptic membrane potential (GO:0060078)3.54048291
43regulation of neurotransmitter secretion (GO:0046928)3.53875040
44cell migration in hindbrain (GO:0021535)3.53575690
45positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.51642263
46positive regulation of synaptic transmission, GABAergic (GO:0032230)3.51322923
47regulation of neurotransmitter levels (GO:0001505)3.50705770
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49952512
49regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.49363620
50postsynaptic membrane organization (GO:0001941)3.49229609
51neurotransmitter-gated ion channel clustering (GO:0072578)3.48801265
52negative regulation of cell fate specification (GO:0009996)3.47188598
53cerebellar Purkinje cell differentiation (GO:0021702)3.45620224
54regulation of synaptic plasticity (GO:0048167)3.44779511
55neuromuscular process controlling posture (GO:0050884)3.43935755
56negative regulation of microtubule polymerization (GO:0031115)3.43500823
57regulation of vesicle fusion (GO:0031338)3.43282327
58sodium ion export (GO:0071436)3.42892529
59regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.42040117
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.41891723
61neuromuscular process controlling balance (GO:0050885)3.37456989
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.32044179
63cell communication by electrical coupling (GO:0010644)3.31124762
64transmission of nerve impulse (GO:0019226)3.27784746
65axonal fasciculation (GO:0007413)3.27467906
66proline biosynthetic process (GO:0006561)3.27391591
67regulation of dendritic spine morphogenesis (GO:0061001)3.25402573
68positive regulation of neurotransmitter secretion (GO:0001956)3.24960513
69auditory behavior (GO:0031223)3.24561765
70dendrite morphogenesis (GO:0048813)3.24364729
71negative regulation of cell fate commitment (GO:0010454)3.24251216
72regulation of neurotransmitter transport (GO:0051588)3.21954699
73membrane depolarization during action potential (GO:0086010)3.21278958
74negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20008051
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.17008118
76membrane depolarization (GO:0051899)3.16437381
77gamma-aminobutyric acid signaling pathway (GO:0007214)3.15884406
78intraspecies interaction between organisms (GO:0051703)3.15097328
79social behavior (GO:0035176)3.15097328
80positive regulation of neurotransmitter transport (GO:0051590)3.14491668
81Golgi transport vesicle coating (GO:0048200)3.14109721
82COPI coating of Golgi vesicle (GO:0048205)3.14109721
83response to auditory stimulus (GO:0010996)3.11325097
84cerebellar granule cell differentiation (GO:0021707)3.11098529
85regulation of synaptic transmission, glutamatergic (GO:0051966)3.10049940
86protein retention in ER lumen (GO:0006621)3.08368630
87neuronal ion channel clustering (GO:0045161)3.08115100
88synapse assembly (GO:0007416)3.07701522
89semaphorin-plexin signaling pathway (GO:0071526)3.06737220
90prepulse inhibition (GO:0060134)3.05583123
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.05539176
92regulation of ARF protein signal transduction (GO:0032012)3.04028081
93dendritic spine organization (GO:0097061)3.02335716
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02115275
95adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.01925264
96vesicle transport along microtubule (GO:0047496)3.01911317
97establishment of mitochondrion localization (GO:0051654)3.01898964
98learning (GO:0007612)3.01475700
99glycine transport (GO:0015816)3.00408266
100mitochondrion transport along microtubule (GO:0047497)2.98721460
101establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.98721460
102dopamine receptor signaling pathway (GO:0007212)2.98613060
103long-term synaptic potentiation (GO:0060291)2.98455432
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98397677
105synaptic transmission (GO:0007268)2.98310644
106positive regulation of dendritic spine development (GO:0060999)2.95647453
107regulation of synaptic transmission (GO:0050804)2.94694195
108membrane hyperpolarization (GO:0060081)2.94588079
109mating behavior (GO:0007617)2.91494365
110behavioral defense response (GO:0002209)2.90998935
111behavioral fear response (GO:0001662)2.90998935
112neuromuscular process (GO:0050905)2.90615306
113cerebellar Purkinje cell layer development (GO:0021680)2.90573396
114organelle transport along microtubule (GO:0072384)2.90274442
115secondary heart field specification (GO:0003139)2.89555030
116heart field specification (GO:0003128)2.89555030
117regulation of dendritic spine development (GO:0060998)2.88625876
118respiratory system process (GO:0003016)2.86894814
119regulation of synapse maturation (GO:0090128)2.86280617
120cell-cell junction maintenance (GO:0045217)2.85027467
121cellular anion homeostasis (GO:0030002)2.78867437
122regulation of mammary gland epithelial cell proliferation (GO:0033599)2.78580898
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.72744269
124maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72707030
125positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.66810366
126retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.63826820
127planar cell polarity pathway involved in neural tube closure (GO:0090179)2.58011414
128proline metabolic process (GO:0006560)2.47064477
129positive regulation of fibroblast migration (GO:0010763)2.46516815
130neuromuscular synaptic transmission (GO:0007274)2.46344774
131potassium ion homeostasis (GO:0055075)2.36866789
132cardiac ventricle formation (GO:0003211)2.35234395
133axon extension (GO:0048675)2.34482997
134cell migration involved in heart development (GO:0060973)2.32447007
135cell migration involved in gastrulation (GO:0042074)2.31693280
136protein maturation by protein folding (GO:0022417)2.31411262
137regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.26929872
138positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.26929872
139amino acid import (GO:0043090)2.24107038
140regulation of protein targeting to membrane (GO:0090313)2.23864441
141regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.23860999
142adenine nucleotide transport (GO:0051503)2.21258374
143positive regulation of cell fate commitment (GO:0010455)2.21044508
144positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.20561297
145adherens junction assembly (GO:0034333)2.19775142
146dendrite development (GO:0016358)2.19055765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.38103222
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.65677331
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.26283696
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.21779005
5GBX2_23144817_ChIP-Seq_PC3_Human3.19061483
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08639541
7REST_21632747_ChIP-Seq_MESCs_Mouse3.05394496
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84056675
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84056675
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.78270290
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.72142568
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.68598210
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65064879
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.64785414
15ZNF263_19887448_ChIP-Seq_K562_Human2.64428284
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63554607
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.61739655
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.58671984
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56656744
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.54493699
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53797175
22DROSHA_22980978_ChIP-Seq_HELA_Human2.50940882
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.41944750
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41820005
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.38258054
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37109172
27LXR_22292898_ChIP-Seq_THP-1_Human2.35902206
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26531115
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.25225414
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.25153004
31* RNF2_27304074_Chip-Seq_ESCs_Mouse2.21635931
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.17780034
33* RACK7_27058665_Chip-Seq_MCF-7_Human2.13881815
34TP63_17297297_ChIP-ChIP_HaCaT_Human2.02987037
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.85603648
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84600028
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.84326225
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.79075456
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73308891
40AR_21572438_ChIP-Seq_LNCaP_Human1.72806495
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71890728
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.68710248
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68314888
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66193950
45TAF15_26573619_Chip-Seq_HEK293_Human1.65748580
46XRN2_22483619_ChIP-Seq_HELA_Human1.64109575
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.63789976
48P68_20966046_ChIP-Seq_HELA_Human1.59876488
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57197682
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56605300
51* ERG_21242973_ChIP-ChIP_JURKAT_Human1.54715808
52CREB1_26743006_Chip-Seq_LNCaP_Human1.53975655
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.52164813
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51101492
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47441539
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46595259
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46492571
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.46480418
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46360812
60SMAD4_21799915_ChIP-Seq_A2780_Human1.46087447
61SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.43937940
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.43003338
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.42797386
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42289190
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40774477
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40417481
67ZNF274_21170338_ChIP-Seq_K562_Hela1.40361643
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39308320
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38807940
70MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.37554332
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37460987
72* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37088830
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36611647
74SMC4_20622854_ChIP-Seq_HELA_Human1.36569745
75* RING1B_27294783_Chip-Seq_ESCs_Mouse1.35847970
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33191439
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33052210
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32672014
79KDM2B_26808549_Chip-Seq_K562_Human1.31502362
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31130371
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27895272
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27286643
83* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26981637
84KDM2B_26808549_Chip-Seq_DND41_Human1.26744379
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26740812
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.25794050
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25573251
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.24781269
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.24431114
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24194297
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23214521
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.22658242
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22566755
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22179881
95IGF1R_20145208_ChIP-Seq_DFB_Human1.20559967
96* FOXP1_21924763_ChIP-Seq_HESCs_Human1.19695171
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18569641
98ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17031460
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16078593
100AR_25329375_ChIP-Seq_VCAP_Human1.16044520
101AR_19668381_ChIP-Seq_PC3_Human1.14548831
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.13016403
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12349171
104CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12188754
105P300_19829295_ChIP-Seq_ESCs_Human1.10949529
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10740696
107P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10257474
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10151905
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09827112
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.09030630
111* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08637074
112MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07926414
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07215302
114CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07211808
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06611018
116WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06596891
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06584824
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05653133
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04982009
120VDR_21846776_ChIP-Seq_THP-1_Human1.04642983
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04591010
122YY1_21170310_ChIP-Seq_MESCs_Mouse1.04354038
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04292294
124STAT3_23295773_ChIP-Seq_U87_Human1.03584578
125* SA1_27219007_Chip-Seq_Bcells_Human1.02987026
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02349720
127* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01919110
128RNF2_27304074_Chip-Seq_NSC_Mouse1.01746578
129CTCF_27219007_Chip-Seq_Bcells_Human1.00324374
130AHR_22903824_ChIP-Seq_MCF-7_Human1.00290240
131* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00199869
132SMAD3_21741376_ChIP-Seq_EPCs_Human1.00021432
133RUNX1_27514584_Chip-Seq_MCF-7_Human1.00006536
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99782830
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97162377
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.95123253
137YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94538191
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94201154
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.92554580
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90181856
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.90167022
142CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90012693
143TCF4_23295773_ChIP-Seq_U87_Human0.89061789
144RXR_22108803_ChIP-Seq_LS180_Human0.86495362
145OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85988688
146VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85435422
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84923471
148KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84061290
149RUNX2_22187159_ChIP-Seq_PCA_Human0.83976608
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.81394102
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80966044
152JUN_21703547_ChIP-Seq_K562_Human0.80326870
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.80275473
154ZFP281_27345836_Chip-Seq_ESCs_Mouse0.79186987
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79179693
156NR3C1_21868756_ChIP-Seq_MCF10A_Human0.75902576
157KLF4_19829295_ChIP-Seq_ESCs_Human0.75200506
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.74835553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.56285556
2MP0003880_abnormal_central_pattern4.90143326
3MP0003635_abnormal_synaptic_transmissio4.20386527
4MP0004270_analgesia3.87676889
5MP0002063_abnormal_learning/memory/cond3.33220696
6MP0009745_abnormal_behavioral_response3.27398533
7MP0001968_abnormal_touch/_nociception3.24148716
8MP0002064_seizures3.06879316
9MP0009046_muscle_twitch3.00712087
10MP0005423_abnormal_somatic_nervous2.98164270
11MP0002734_abnormal_mechanical_nocicepti2.82572072
12MP0002735_abnormal_chemical_nociception2.71656822
13MP0002572_abnormal_emotion/affect_behav2.71429541
14MP0002272_abnormal_nervous_system2.48820684
15MP0002733_abnormal_thermal_nociception2.46581253
16MP0002736_abnormal_nociception_after2.44957470
17MP0006276_abnormal_autonomic_nervous2.39565659
18MP0002822_catalepsy2.37171960
19MP0002234_abnormal_pharynx_morphology2.33115397
20MP0001486_abnormal_startle_reflex2.29097051
21MP0001501_abnormal_sleep_pattern2.28678409
22MP0001970_abnormal_pain_threshold2.27078177
23MP0001440_abnormal_grooming_behavior2.23659497
24MP0004858_abnormal_nervous_system2.12547570
25MP0002184_abnormal_innervation2.02347235
26MP0003705_abnormal_hypodermis_morpholog2.01775751
27MP0003329_amyloid_beta_deposits2.00266153
28MP0002067_abnormal_sensory_capabilities1.99748335
29MP0010030_abnormal_orbit_morphology1.98514306
30MP0002909_abnormal_adrenal_gland1.97272398
31MP0000537_abnormal_urethra_morphology1.93791031
32MP0004811_abnormal_neuron_physiology1.91176162
33MP0008569_lethality_at_weaning1.88872575
34MP0000778_abnormal_nervous_system1.87881084
35MP0009780_abnormal_chondrocyte_physiolo1.80863603
36MP0002557_abnormal_social/conspecific_i1.80400253
37MP0005645_abnormal_hypothalamus_physiol1.74218305
38MP0004924_abnormal_behavior1.72168107
39MP0005386_behavior/neurological_phenoty1.72168107
40MP0000579_abnormal_nail_morphology1.68274696
41MP0001984_abnormal_olfaction1.66241679
42MP0000955_abnormal_spinal_cord1.63812281
43MP0003122_maternal_imprinting1.62253952
44MP0005646_abnormal_pituitary_gland1.61849180
45MP0003879_abnormal_hair_cell1.57272466
46MP0000566_synostosis1.56575742
47MP0001346_abnormal_lacrimal_gland1.50066972
48MP0002066_abnormal_motor_capabilities/c1.43591411
49MP0002249_abnormal_larynx_morphology1.42264082
50MP0002882_abnormal_neuron_morphology1.39507929
51MP0002796_impaired_skin_barrier1.38552629
52MP0003787_abnormal_imprinting1.32634614
53MP0001502_abnormal_circadian_rhythm1.32458716
54MP0003633_abnormal_nervous_system1.30674838
55MP0001905_abnormal_dopamine_level1.26868326
56MP0001529_abnormal_vocalization1.26148280
57MP0004885_abnormal_endolymph1.25942693
58MP0009379_abnormal_foot_pigmentation1.21093409
59MP0010386_abnormal_urinary_bladder1.20886703
60MP0003942_abnormal_urinary_system1.19298651
61MP0004142_abnormal_muscle_tone1.14881148
62MP0000462_abnormal_digestive_system1.10451641
63MP0005501_abnormal_skin_physiology1.08644212
64MP0000569_abnormal_digit_pigmentation1.07494993
65MP0004145_abnormal_muscle_electrophysio1.05536600
66MP0002152_abnormal_brain_morphology1.05427910
67MP0003631_nervous_system_phenotype1.05153791
68MP0000751_myopathy1.04543135
69MP0001299_abnormal_eye_distance/1.02466063
70MP0005623_abnormal_meninges_morphology1.01624749
71MP0008872_abnormal_physiological_respon1.00858937
72MP0003315_abnormal_perineum_morphology1.00470826
73MP0008961_abnormal_basal_metabolism0.98322041
74MP0002089_abnormal_postnatal_growth/wei0.96567938
75MP0002837_dystrophic_cardiac_calcinosis0.96216549
76MP0005257_abnormal_intraocular_pressure0.95593374
77MP0000678_abnormal_parathyroid_gland0.95266271
78MP0000538_abnormal_urinary_bladder0.94583794
79MP0002069_abnormal_eating/drinking_beha0.94123285
80MP0001849_ear_inflammation0.92954037
81MP0000604_amyloidosis0.91934607
82MP0003938_abnormal_ear_development0.91333041
83MP0002229_neurodegeneration0.91258829
84MP0002638_abnormal_pupillary_reflex0.90818262
85MP0000534_abnormal_ureter_morphology0.89088804
86MP0009672_abnormal_birth_weight0.85971548
87MP0000013_abnormal_adipose_tissue0.84210018
88MP0004742_abnormal_vestibular_system0.84134739
89MP0005535_abnormal_body_temperature0.83003675
90MP0005394_taste/olfaction_phenotype0.82901637
91MP0005499_abnormal_olfactory_system0.82901637
92MP0008874_decreased_physiological_sensi0.82689229
93MP0008932_abnormal_embryonic_tissue0.81897277
94MP0005666_abnormal_adipose_tissue0.81013829
95MP0004510_myositis0.79887036
96MP0004085_abnormal_heartbeat0.79861054
97MP0003634_abnormal_glial_cell0.79461948
98MP0004133_heterotaxia0.79296928
99MP0001188_hyperpigmentation0.76477947
100MP0003119_abnormal_digestive_system0.75440696
101MP0002081_perinatal_lethality0.74669439
102MP0004264_abnormal_extraembryonic_tissu0.74551206
103MP0000003_abnormal_adipose_tissue0.74398870
104MP0002177_abnormal_outer_ear0.74290498
105MP0004782_abnormal_surfactant_physiolog0.72914560
106MP0002932_abnormal_joint_morphology0.72731314
107MP0002752_abnormal_somatic_nervous0.71897910
108MP0001177_atelectasis0.71473404
109MP0000631_abnormal_neuroendocrine_gland0.69947225
110MP0000467_abnormal_esophagus_morphology0.69113068
111MP0002751_abnormal_autonomic_nervous0.68563064
112MP0001963_abnormal_hearing_physiology0.68184279
113MP0000762_abnormal_tongue_morphology0.68011222
114MP0000049_abnormal_middle_ear0.67273029
115MP0003172_abnormal_lysosome_physiology0.67172208
116MP0009384_cardiac_valve_regurgitation0.67022888
117MP0005375_adipose_tissue_phenotype0.66740143
118MP0004185_abnormal_adipocyte_glucose0.63743320
119MP0003283_abnormal_digestive_organ0.63549432
120MP0001664_abnormal_digestion0.63008305
121MP0003632_abnormal_nervous_system0.62442693
122MP0004484_altered_response_of0.62409685
123MP0001348_abnormal_lacrimal_gland0.61111300
124MP0003075_altered_response_to0.60530282
125MP0003183_abnormal_peptide_metabolism0.59355039
126MP0010234_abnormal_vibrissa_follicle0.57097681
127MP0000920_abnormal_myelination0.56940788
128MP0003137_abnormal_impulse_conducting0.54983367
129MP0004215_abnormal_myocardial_fiber0.54180480
130MP0010769_abnormal_survival0.54125257
131MP0003121_genomic_imprinting0.54098375
132MP0001986_abnormal_taste_sensitivity0.53416319
133MP0003861_abnormal_nervous_system0.53024868
134MP0005167_abnormal_blood-brain_barrier0.52932711
135MP0005409_darkened_coat_color0.52279664
136MP0003956_abnormal_body_size0.52272171
137MP0010770_preweaning_lethality0.52056563
138MP0002082_postnatal_lethality0.52056563
139MP0003123_paternal_imprinting0.51100941
140MP0010768_mortality/aging0.51075348
141MP0001943_abnormal_respiration0.50778112

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.16415172
2Myokymia (HP:0002411)6.99964907
3Focal seizures (HP:0007359)5.69202033
4Visual hallucinations (HP:0002367)5.65325246
5Atonic seizures (HP:0010819)4.49184433
6Epileptic encephalopathy (HP:0200134)4.44832065
7Progressive cerebellar ataxia (HP:0002073)4.36397614
8Supranuclear gaze palsy (HP:0000605)4.26590625
9Febrile seizures (HP:0002373)4.22282066
10Absence seizures (HP:0002121)3.95680887
11Mutism (HP:0002300)3.86585006
12Ankle clonus (HP:0011448)3.84059417
13Generalized tonic-clonic seizures (HP:0002069)3.75715967
14Action tremor (HP:0002345)3.71337470
15Dialeptic seizures (HP:0011146)3.61230327
16Abnormal eating behavior (HP:0100738)3.48722070
17Poor eye contact (HP:0000817)3.46916418
18Failure to thrive in infancy (HP:0001531)3.26942277
19Papilledema (HP:0001085)3.26715761
20Depression (HP:0000716)3.25672679
21Broad-based gait (HP:0002136)3.24295360
22Amblyopia (HP:0000646)3.21447388
23Polyphagia (HP:0002591)3.20779553
24Impaired social interactions (HP:0000735)3.15466915
25Abnormal social behavior (HP:0012433)3.15466915
26Truncal ataxia (HP:0002078)3.13559261
27Limb dystonia (HP:0002451)3.09845278
28Agitation (HP:0000713)3.08470910
29Birth length less than 3rd percentile (HP:0003561)2.98603989
30Anxiety (HP:0000739)2.97061564
31Impaired vibration sensation in the lower limbs (HP:0002166)2.96394614
32Abnormality of the lower motor neuron (HP:0002366)2.95606175
33Progressive inability to walk (HP:0002505)2.94385786
34Drooling (HP:0002307)2.93382734
35Excessive salivation (HP:0003781)2.93382734
36Hyperacusis (HP:0010780)2.92675631
37Urinary bladder sphincter dysfunction (HP:0002839)2.92540176
38Long palpebral fissure (HP:0000637)2.92064819
39Genetic anticipation (HP:0003743)2.88233087
40Pheochromocytoma (HP:0002666)2.83319545
41Gaze-evoked nystagmus (HP:0000640)2.81022228
42Sparse lateral eyebrow (HP:0005338)2.79705219
43Ventricular fibrillation (HP:0001663)2.71448089
44Dysmetria (HP:0001310)2.71349777
45Postural instability (HP:0002172)2.69636725
46Hemiparesis (HP:0001269)2.67715444
47Distal upper limb amyotrophy (HP:0007149)2.67354958
48Upper limb amyotrophy (HP:0009129)2.67354958
49Abnormality of binocular vision (HP:0011514)2.63390394
50Diplopia (HP:0000651)2.63390394
51Torticollis (HP:0000473)2.63383774
52Dysdiadochokinesis (HP:0002075)2.63314284
53Urinary urgency (HP:0000012)2.61423123
54Hyperventilation (HP:0002883)2.54993523
55Bradykinesia (HP:0002067)2.54358931
56Testicular atrophy (HP:0000029)2.52706927
57Amyotrophic lateral sclerosis (HP:0007354)2.52329718
58Impaired smooth pursuit (HP:0007772)2.51083177
59Stereotypic behavior (HP:0000733)2.48781433
60Spastic gait (HP:0002064)2.48689156
61Hand muscle atrophy (HP:0009130)2.48658222
62Inability to walk (HP:0002540)2.48449718
63Epileptiform EEG discharges (HP:0011182)2.44746053
64Focal dystonia (HP:0004373)2.44120737
65Neonatal hypoglycemia (HP:0001998)2.43143780
66Neuroendocrine neoplasm (HP:0100634)2.42806686
67Hyperthyroidism (HP:0000836)2.42537775
68Hemiplegia (HP:0002301)2.41745188
69EEG with generalized epileptiform discharges (HP:0011198)2.39162416
70Cerebral hypomyelination (HP:0006808)2.36972928
71Lip pit (HP:0100267)2.36899088
72Cerebral inclusion bodies (HP:0100314)2.35041602
73Turricephaly (HP:0000262)2.32941815
74Neurofibrillary tangles (HP:0002185)2.29835575
75Hypsarrhythmia (HP:0002521)2.28622963
76Premature skin wrinkling (HP:0100678)2.26444322
77Anterior segment dysgenesis (HP:0007700)2.25771458
78Thin bony cortex (HP:0002753)2.25532247
79Myotonia (HP:0002486)2.24272232
80Hyperparathyroidism (HP:0000843)2.23929264
81Termporal pattern (HP:0011008)2.23042201
82Insidious onset (HP:0003587)2.23042201
83Abnormality of the corticospinal tract (HP:0002492)2.21771025
84Craniofacial dystonia (HP:0012179)2.20987210
85Lower limb muscle weakness (HP:0007340)2.20257758
86Fetal akinesia sequence (HP:0001989)2.18216594
87Scanning speech (HP:0002168)2.17604621
88Sleep apnea (HP:0010535)2.17346212
89Insomnia (HP:0100785)2.16184808
90Abnormality of ocular smooth pursuit (HP:0000617)2.15440582
91Status epilepticus (HP:0002133)2.14574447
92Annular pancreas (HP:0001734)2.14042221
93Apathy (HP:0000741)2.11901049
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11687029
95Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11687029
96Megalencephaly (HP:0001355)2.10653156
97Bundle branch block (HP:0011710)2.08403728
98Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06686355
99Hypoplasia of the brainstem (HP:0002365)2.06686355
100Rapidly progressive (HP:0003678)2.05843897
101Dysmetric saccades (HP:0000641)2.05220263
102Truncus arteriosus (HP:0001660)2.05134021
103Hypoventilation (HP:0002791)2.05048500
104Neuronal loss in central nervous system (HP:0002529)2.02481709
105Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.01866236
106Absent speech (HP:0001344)2.01563749
107Exotropia (HP:0000577)2.01275163
108Overriding aorta (HP:0002623)1.99222836
109Pointed chin (HP:0000307)1.99066028
110Akinesia (HP:0002304)1.97428766
111Inappropriate behavior (HP:0000719)1.96828075
112Spinal cord compression (HP:0002176)1.96591414
113Esotropia (HP:0000565)1.96462187
114Rigidity (HP:0002063)1.94754842
115Psychosis (HP:0000709)1.94723945
116Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94696325
117Clonus (HP:0002169)1.94645812
118Delusions (HP:0000746)1.94210898
119Lower limb amyotrophy (HP:0007210)1.94082690
120Abnormality of salivation (HP:0100755)1.93655324
121Chin dimple (HP:0010751)1.92911549
122Abnormal EKG (HP:0003115)1.92878550
123Intention tremor (HP:0002080)1.92527191
124Shallow orbits (HP:0000586)1.92169544
125Generalized myoclonic seizures (HP:0002123)1.92079089
126Obstructive sleep apnea (HP:0002870)1.92052273
127Neoplasm of the peripheral nervous system (HP:0100007)1.91975688
128Megalocornea (HP:0000485)1.86918546
129Ulnar bowing (HP:0003031)1.85191655
130Septate vagina (HP:0001153)1.84812213
131Enlarged epiphyses (HP:0010580)1.84590185
132Partial duplication of thumb phalanx (HP:0009944)1.83283007
133Congenital glaucoma (HP:0001087)1.82586479
134Concave nail (HP:0001598)1.81628798
135Stridor (HP:0010307)1.79192488
136Elfin facies (HP:0004428)1.78491339
137Distal lower limb amyotrophy (HP:0008944)1.76690001
138Precocious puberty (HP:0000826)1.75131613
139Nuclear cataract (HP:0100018)1.74363779
140Renal duplication (HP:0000075)1.71859894
141Hypercalcemia (HP:0003072)1.69157362
142Lower limb asymmetry (HP:0100559)1.68143978
143Generalized hypotonia (HP:0001290)1.64958528
144Mildly elevated creatine phosphokinase (HP:0008180)1.64466276
145Preauricular skin tag (HP:0000384)1.62693693
146Patellar dislocation (HP:0002999)1.61230111
147Diminished motivation (HP:0000745)1.60497743
148Bronchomalacia (HP:0002780)1.59050218
149Poor suck (HP:0002033)1.57821637
150J-shaped sella turcica (HP:0002680)1.57184241
151Partial duplication of the phalanx of hand (HP:0009999)1.56526541
152Long foot (HP:0001833)1.55300173
153Achilles tendon contracture (HP:0001771)1.55065311
154CNS hypomyelination (HP:0003429)1.54656117
155Insulin-resistant diabetes mellitus (HP:0000831)1.54243928
156Retinal dysplasia (HP:0007973)1.53807960
157Neonatal onset (HP:0003623)1.52496831
158Bowel diverticulosis (HP:0005222)1.51952290
159Spastic tetraparesis (HP:0001285)1.51751982
160Enlarged penis (HP:0000040)1.50856172
161Buphthalmos (HP:0000557)1.50352840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.15029485
2MAP3K94.14168132
3TRIB33.94319875
4MARK13.85153217
5EPHA43.48194938
6MINK12.99671029
7MAP3K42.99463275
8TLK12.82196298
9MAP2K72.74223363
10MAP3K122.56153938
11DAPK22.44008210
12TESK12.40936525
13EPHA22.30252714
14PAK62.29237157
15PIK3CA2.27534402
16NTRK12.14571901
17NTRK22.07761829
18KSR22.06350828
19SIK12.05299053
20MAP2K42.01125876
21RIPK41.97330720
22NME21.90140455
23PTK21.86889572
24GRK51.81441181
25CAMKK11.70034996
26CDK191.68458762
27PRKD31.67530508
28CDK51.64257706
29RIPK11.62067033
30WNK31.60577672
31DAPK11.56064525
32KSR11.55135417
33PKN21.55063142
34MAPK131.51994422
35SIK21.47678892
36SMG11.46844767
37ARAF1.45241537
38CASK1.45086198
39LATS21.36383064
40IRAK31.34375595
41MST1R1.33876186
42CAMK1D1.31660556
43PHKG11.31645897
44PHKG21.31645897
45STK381.27495956
46UHMK11.24968347
47PNCK1.23288873
48ICK1.22153655
49PLK21.22046695
50TNIK1.20565213
51PRKCG1.17978279
52FES1.16876248
53CAMKK21.16522829
54TAOK11.12004665
55CAMK1G1.08282616
56MAP3K21.07930653
57MAP3K131.02369411
58RET0.98728187
59VRK20.98596520
60MAP3K110.97991230
61LMTK20.97857980
62STK160.92687894
63CSNK1G20.91616062
64CDK180.91261275
65TYRO30.91067084
66STK110.87438939
67CDK150.87218857
68CDK140.86581889
69ALK0.84428050
70CAMK2A0.83666377
71PRKCH0.82611939
72MARK20.82258215
73PRPF4B0.78462720
74CDK11A0.78309857
75CAMK10.78199481
76SIK30.77191894
77AURKA0.77094632
78ILK0.76725750
79CCNB10.75678996
80PRKCI0.75574114
81RAF10.74792365
82SGK2230.74494259
83SGK4940.74494259
84PAK40.71894534
85EEF2K0.71876251
86PAK30.71840017
87PINK10.69730964
88TESK20.68124241
89MAPK150.67917750
90DYRK1A0.67003204
91PIM20.66675212
92MET0.65631637
93CAMK2B0.63538399
94RPS6KA20.63328858
95PDK10.63275117
96MAP3K10.62470381
97IRAK20.62013191
98SGK20.58368254
99DMPK0.57527971
100SCYL20.55592681
101BMPR20.54854707
102AKT20.53897764
103EIF2AK10.53118884
104PDGFRA0.52620311
105MTOR0.52173053
106SGK30.51794391
107PDPK10.51709952
108PRKCZ0.50957586
109PTK2B0.50274916
110FER0.49674362
111NME10.49554434
112PAK10.48651183
113LIMK10.47799901
114SGK10.47274254
115CDC42BPA0.46449205
116CSNK1G30.45864816
117MAP3K100.45381688
118BRSK10.44132786
119PRKCE0.43600799
120FYN0.43017761
121DYRK20.42999408
122CSNK1A1L0.41307948
123RPS6KA30.41063462
124MAPK120.40481167
125MUSK0.39411674
126PRKG20.39204397
127OXSR10.38429070
128RPS6KB20.37434792
129PTK60.37072484
130PRKD20.36721408
131MAPK100.36620255
132BUB10.36073251
133CAMK2G0.35812209
134CAMK2D0.35533317
135EPHB20.34207720
136DAPK30.33862258
137NEK10.33819235
138CAMK40.33525000
139MAP2K10.32823672
140BRAF0.32585314
141TNK20.31848481
142MAP3K60.30009055
143MAP2K60.29219617

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.56762573
2Nicotine addiction_Homo sapiens_hsa050333.47727419
3Vitamin B6 metabolism_Homo sapiens_hsa007502.97763501
4Olfactory transduction_Homo sapiens_hsa047402.64512790
5Long-term potentiation_Homo sapiens_hsa047202.62845989
6Circadian entrainment_Homo sapiens_hsa047132.55202149
7GABAergic synapse_Homo sapiens_hsa047272.54291464
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48401361
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47929439
10Glutamatergic synapse_Homo sapiens_hsa047242.38783284
11Amphetamine addiction_Homo sapiens_hsa050312.36215627
12Morphine addiction_Homo sapiens_hsa050322.30806404
13Dopaminergic synapse_Homo sapiens_hsa047282.15774683
14Insulin secretion_Homo sapiens_hsa049112.09677431
15Salivary secretion_Homo sapiens_hsa049702.06129201
16Cholinergic synapse_Homo sapiens_hsa047251.92373471
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81304858
18Gastric acid secretion_Homo sapiens_hsa049711.80992907
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80783646
20Taste transduction_Homo sapiens_hsa047421.77535376
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68329438
22Collecting duct acid secretion_Homo sapiens_hsa049661.66844304
23Long-term depression_Homo sapiens_hsa047301.63108933
24Cocaine addiction_Homo sapiens_hsa050301.62119628
25Oxytocin signaling pathway_Homo sapiens_hsa049211.60325950
26Serotonergic synapse_Homo sapiens_hsa047261.58764340
27Renin secretion_Homo sapiens_hsa049241.57073106
28GnRH signaling pathway_Homo sapiens_hsa049121.49551285
29Gap junction_Homo sapiens_hsa045401.45902691
30Calcium signaling pathway_Homo sapiens_hsa040201.45813038
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.43252864
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40365522
33Pentose phosphate pathway_Homo sapiens_hsa000301.40069211
34Sulfur relay system_Homo sapiens_hsa041221.32539095
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.30161756
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29451856
37Type II diabetes mellitus_Homo sapiens_hsa049301.21161584
38Estrogen signaling pathway_Homo sapiens_hsa049151.21142384
39cAMP signaling pathway_Homo sapiens_hsa040241.17563114
40Vibrio cholerae infection_Homo sapiens_hsa051101.17215324
41Fructose and mannose metabolism_Homo sapiens_hsa000511.14699350
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14341389
43Axon guidance_Homo sapiens_hsa043601.12861690
44Glioma_Homo sapiens_hsa052141.10566127
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06247239
46Biosynthesis of amino acids_Homo sapiens_hsa012301.05596924
47Cardiac muscle contraction_Homo sapiens_hsa042601.03335459
48ErbB signaling pathway_Homo sapiens_hsa040121.01719863
49Melanogenesis_Homo sapiens_hsa049161.00841274
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98045136
51Oocyte meiosis_Homo sapiens_hsa041140.97957853
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94611723
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93074754
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.91803606
55Hippo signaling pathway_Homo sapiens_hsa043900.90569681
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90430645
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.89807328
58AMPK signaling pathway_Homo sapiens_hsa041520.87486713
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86310603
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.86274448
61Pancreatic secretion_Homo sapiens_hsa049720.85901356
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85515982
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85406513
64Oxidative phosphorylation_Homo sapiens_hsa001900.84430194
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.83782499
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83332713
67Dorso-ventral axis formation_Homo sapiens_hsa043200.82604035
68MAPK signaling pathway_Homo sapiens_hsa040100.77179166
69VEGF signaling pathway_Homo sapiens_hsa043700.76819082
70Thyroid hormone synthesis_Homo sapiens_hsa049180.76418008
71Folate biosynthesis_Homo sapiens_hsa007900.74490552
72Choline metabolism in cancer_Homo sapiens_hsa052310.74181744
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74174801
74Parkinsons disease_Homo sapiens_hsa050120.72696391
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72206774
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71116937
77Dilated cardiomyopathy_Homo sapiens_hsa054140.69368513
78Basal cell carcinoma_Homo sapiens_hsa052170.69333447
79Notch signaling pathway_Homo sapiens_hsa043300.67930135
80Type I diabetes mellitus_Homo sapiens_hsa049400.65515455
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65313673
82Carbon metabolism_Homo sapiens_hsa012000.64809161
83mTOR signaling pathway_Homo sapiens_hsa041500.62773174
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.61742227
85Galactose metabolism_Homo sapiens_hsa000520.59978497
86Base excision repair_Homo sapiens_hsa034100.59697276
87Endocytosis_Homo sapiens_hsa041440.59690925
88Chronic myeloid leukemia_Homo sapiens_hsa052200.58692874
89Tight junction_Homo sapiens_hsa045300.58668297
90Huntingtons disease_Homo sapiens_hsa050160.58113018
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57047879
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56653169
93Endometrial cancer_Homo sapiens_hsa052130.56572102
94mRNA surveillance pathway_Homo sapiens_hsa030150.56536533
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56450215
96Ras signaling pathway_Homo sapiens_hsa040140.56130054
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55579730
98Glucagon signaling pathway_Homo sapiens_hsa049220.55263995
99DNA replication_Homo sapiens_hsa030300.54895546
100Ribosome_Homo sapiens_hsa030100.53381776
101Rap1 signaling pathway_Homo sapiens_hsa040150.52199664
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51895526
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50947191
104Insulin signaling pathway_Homo sapiens_hsa049100.50022392
105Phenylalanine metabolism_Homo sapiens_hsa003600.49859110
106Steroid biosynthesis_Homo sapiens_hsa001000.48544534
107Inositol phosphate metabolism_Homo sapiens_hsa005620.48212188
108Phototransduction_Homo sapiens_hsa047440.47371151
109Melanoma_Homo sapiens_hsa052180.47116333
110Thyroid cancer_Homo sapiens_hsa052160.47069143
111Arginine and proline metabolism_Homo sapiens_hsa003300.46566237
112Renal cell carcinoma_Homo sapiens_hsa052110.46363887
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45793385
114Regulation of autophagy_Homo sapiens_hsa041400.44466533
115Alzheimers disease_Homo sapiens_hsa050100.44293775
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44185574
117Non-small cell lung cancer_Homo sapiens_hsa052230.44061456
118Alcoholism_Homo sapiens_hsa050340.43037020
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42586443
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41553679
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41475972
122Prion diseases_Homo sapiens_hsa050200.40926344
123Prolactin signaling pathway_Homo sapiens_hsa049170.40575522
124Circadian rhythm_Homo sapiens_hsa047100.39910796
125Chemokine signaling pathway_Homo sapiens_hsa040620.37339612
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36753546
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36742895
128Colorectal cancer_Homo sapiens_hsa052100.36652335
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.34557217
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34005901
131Wnt signaling pathway_Homo sapiens_hsa043100.33472617
132Rheumatoid arthritis_Homo sapiens_hsa053230.31014699
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29028939

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