RUVBL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.08444969
2DNA strand elongation involved in DNA replication (GO:0006271)4.95190342
3DNA replication initiation (GO:0006270)4.74042052
4formation of translation preinitiation complex (GO:0001731)4.73517630
5DNA strand elongation (GO:0022616)4.73379364
6nucleobase biosynthetic process (GO:0046112)4.72049533
7maturation of SSU-rRNA (GO:0030490)4.71225866
8telomere maintenance via semi-conservative replication (GO:0032201)4.61826832
9DNA deamination (GO:0045006)4.58300443
10DNA unwinding involved in DNA replication (GO:0006268)4.56466989
11purine nucleobase biosynthetic process (GO:0009113)4.48979194
12ribosome biogenesis (GO:0042254)4.19064589
13viral transcription (GO:0019083)4.14011350
14ribosomal large subunit biogenesis (GO:0042273)4.11114079
15telomere maintenance via recombination (GO:0000722)4.10123943
16translational termination (GO:0006415)4.10083168
17DNA replication checkpoint (GO:0000076)4.08388693
18ribonucleoprotein complex biogenesis (GO:0022613)4.06921197
19IMP biosynthetic process (GO:0006188)4.01937178
20ribosome assembly (GO:0042255)3.88865942
21ribosomal small subunit biogenesis (GO:0042274)3.88733145
22mitotic metaphase plate congression (GO:0007080)3.85428774
23pseudouridine synthesis (GO:0001522)3.84868890
24translational elongation (GO:0006414)3.83691980
25protein localization to kinetochore (GO:0034501)3.83448659
26mitotic recombination (GO:0006312)3.83349709
27translational initiation (GO:0006413)3.78182313
28telomere maintenance via telomere lengthening (GO:0010833)3.77423096
29nuclear pore complex assembly (GO:0051292)3.76149031
30spliceosomal snRNP assembly (GO:0000387)3.74284673
31rRNA processing (GO:0006364)3.69634868
32establishment of viral latency (GO:0019043)3.69633585
33mitotic chromosome condensation (GO:0007076)3.66196680
34folic acid-containing compound biosynthetic process (GO:0009396)3.64765081
35proteasome assembly (GO:0043248)3.64701428
36IMP metabolic process (GO:0046040)3.59061083
37mitotic nuclear envelope disassembly (GO:0007077)3.58244675
38* CENP-A containing nucleosome assembly (GO:0034080)3.57038246
39rRNA metabolic process (GO:0016072)3.56699013
40DNA replication-dependent nucleosome organization (GO:0034723)3.56554729
41DNA replication-dependent nucleosome assembly (GO:0006335)3.56554729
42sister chromatid segregation (GO:0000819)3.52711874
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50361432
44* chromatin remodeling at centromere (GO:0031055)3.49940866
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.48900010
46SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.46423882
47regulation of translational fidelity (GO:0006450)3.44469130
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.42345792
49regulation of mitochondrial translation (GO:0070129)3.40734092
50rRNA modification (GO:0000154)3.40444395
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.40012222
52peptidyl-arginine omega-N-methylation (GO:0035247)3.39402385
53metaphase plate congression (GO:0051310)3.39388486
54DNA ligation (GO:0006266)3.38210243
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38084737
56cotranslational protein targeting to membrane (GO:0006613)3.37021659
57viral mRNA export from host cell nucleus (GO:0046784)3.35591270
58protein targeting to ER (GO:0045047)3.35098867
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33452163
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32802596
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32726340
62protein localization to chromosome, centromeric region (GO:0071459)3.31350834
63L-serine metabolic process (GO:0006563)3.30846729
64membrane disassembly (GO:0030397)3.28883176
65nuclear envelope disassembly (GO:0051081)3.28883176
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28496273
67kinetochore organization (GO:0051383)3.27392210
68* DNA replication-independent nucleosome organization (GO:0034724)3.26790924
69* DNA replication-independent nucleosome assembly (GO:0006336)3.26790924
70cellular protein complex disassembly (GO:0043624)3.24461917
71transcription-coupled nucleotide-excision repair (GO:0006283)3.24429782
72establishment of integrated proviral latency (GO:0075713)3.24316389
73establishment of protein localization to mitochondrial membrane (GO:0090151)3.22991173
74viral life cycle (GO:0019058)3.20529359
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.19801340
76negative regulation of ligase activity (GO:0051352)3.19801340
77tRNA aminoacylation for protein translation (GO:0006418)3.17302691
78cellular component biogenesis (GO:0044085)3.16945035
79histone arginine methylation (GO:0034969)3.16935799
80somatic hypermutation of immunoglobulin genes (GO:0016446)3.16748615
81somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16748615
82establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16530050
83protein localization to endoplasmic reticulum (GO:0070972)3.16469576
84attachment of spindle microtubules to kinetochore (GO:0008608)3.15880720
85translation (GO:0006412)3.14237918
86nuclear pore organization (GO:0006999)3.11680120
87cell cycle G1/S phase transition (GO:0044843)3.11678790
88G1/S transition of mitotic cell cycle (GO:0000082)3.11678790
89kinetochore assembly (GO:0051382)3.11136308
90amino acid activation (GO:0043038)3.11090586
91tRNA aminoacylation (GO:0043039)3.11090586
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10816156
93double-strand break repair via nonhomologous end joining (GO:0006303)3.08133939
94non-recombinational repair (GO:0000726)3.08133939
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07604799
96spliceosomal complex assembly (GO:0000245)3.06948274
97negative regulation of chromosome segregation (GO:0051985)3.06921526
98maturation of 5.8S rRNA (GO:0000460)3.06387100
99DNA topological change (GO:0006265)3.05082783
100DNA damage response, detection of DNA damage (GO:0042769)3.04803293
101spindle checkpoint (GO:0031577)3.04655149
102transcription elongation from RNA polymerase III promoter (GO:0006385)3.03753657
103termination of RNA polymerase III transcription (GO:0006386)3.03753657
104negative regulation of mRNA processing (GO:0050686)3.02750394
105DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02079391
106protein complex localization (GO:0031503)3.01086375
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00455228
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00455228
109negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00455228
110negative regulation of mitotic sister chromatid separation (GO:2000816)3.00455228
111negative regulation of sister chromatid segregation (GO:0033046)3.00455228
112establishment of chromosome localization (GO:0051303)3.00239267
113intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98242362
114signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98242362
115mitotic spindle checkpoint (GO:0071174)2.97736322
116protein complex disassembly (GO:0043241)2.97645733
117base-excision repair (GO:0006284)2.97546788
1187-methylguanosine mRNA capping (GO:0006370)2.97012891
119signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96592883
120signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96592883
121signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96592883
122mitochondrial RNA metabolic process (GO:0000959)2.94385799
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94007758
124pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.93995920
125nuclear-transcribed mRNA catabolic process (GO:0000956)2.93748766
126cullin deneddylation (GO:0010388)2.93693797
127RNA capping (GO:0036260)2.93500426
1287-methylguanosine RNA capping (GO:0009452)2.93500426
129signal transduction involved in DNA damage checkpoint (GO:0072422)2.93414849
130signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93414849
131regulation of chromosome segregation (GO:0051983)2.93185997
132folic acid metabolic process (GO:0046655)2.92913876
133* histone exchange (GO:0043486)2.92835838
134ncRNA processing (GO:0034470)2.92510736
135mitotic sister chromatid segregation (GO:0000070)2.92329014
136mitotic spindle assembly checkpoint (GO:0007094)2.90506582
137mitotic sister chromatid cohesion (GO:0007064)2.89856653
138negative regulation of RNA splicing (GO:0033119)2.89666570
139spindle assembly checkpoint (GO:0071173)2.87582268
140nucleobase-containing small molecule interconversion (GO:0015949)2.86821303
141peptidyl-arginine methylation (GO:0018216)2.86178706
142peptidyl-arginine N-methylation (GO:0035246)2.86178706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.86355149
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.64688523
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04615522
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46444463
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40685913
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.23309745
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.20847023
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16180917
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14427592
10* GABP_17652178_ChIP-ChIP_JURKAT_Human3.07387077
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07013005
12* ETS1_20019798_ChIP-Seq_JURKAT_Human3.05665993
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01322365
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87529415
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78358765
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72455466
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55467523
18XRN2_22483619_ChIP-Seq_HELA_Human2.44294884
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41736161
20* VDR_23849224_ChIP-Seq_CD4+_Human2.36387172
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33037184
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15193925
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11828569
24* FOXP3_21729870_ChIP-Seq_TREG_Human2.10927826
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10360399
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03143162
27DCP1A_22483619_ChIP-Seq_HELA_Human2.01460288
28* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01347544
29* GABP_19822575_ChIP-Seq_HepG2_Human2.01252804
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95482923
31* AR_21909140_ChIP-Seq_LNCAP_Human1.92779566
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92521430
33TTF2_22483619_ChIP-Seq_HELA_Human1.92403939
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88801541
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86852466
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.85963436
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83623552
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82621809
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73334077
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72428169
41CIITA_25753668_ChIP-Seq_RAJI_Human1.72090639
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.71785363
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71277824
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70280545
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65290046
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65105767
47ELK1_19687146_ChIP-ChIP_HELA_Human1.64179500
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63862743
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61520416
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.59162873
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.58638151
52* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53175599
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52222315
54MYC_22102868_ChIP-Seq_BL_Human1.52028666
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.42928769
56KDM5A_27292631_Chip-Seq_BREAST_Human1.42774235
57* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41541264
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41349664
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36501350
60* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34358148
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33988924
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33655338
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33522343
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24672379
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23941259
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23865544
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18978132
68ZNF263_19887448_ChIP-Seq_K562_Human1.16302379
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15496186
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15380844
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14969450
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13124740
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12826127
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12083483
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.11945404
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10408217
77TFEB_21752829_ChIP-Seq_HELA_Human1.09732438
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06772518
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06513091
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06463611
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05288897
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04789676
83MYC_18940864_ChIP-ChIP_HL60_Human1.03947338
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03421373
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02142444
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01812691
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00159671
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99615482
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97502848
90NANOG_16153702_ChIP-ChIP_HESCs_Human0.97025755
91ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96766426
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95925977
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.94723862
94VDR_21846776_ChIP-Seq_THP-1_Human0.94212883
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.94060989
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94019205
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.92938133
98* SPI1_23547873_ChIP-Seq_NB4_Human0.92048515
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90963257
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89135968
101* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88275800
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87357142
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85585597
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85199664
105* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85105565
106TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83387944
107CHD1_26751641_Chip-Seq_LNCaP_Human0.82543830
108TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77832768
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77672290
110FOXP1_21924763_ChIP-Seq_HESCs_Human0.77634363
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77574165
112* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77101541
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75918032
114NANOG_21062744_ChIP-ChIP_HESCs_Human0.75664001
115CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74637198
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74539229
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73389674
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73093649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.69166380
2MP0010094_abnormal_chromosome_stability4.87981137
3MP0004957_abnormal_blastocyst_morpholog4.80027646
4MP0003111_abnormal_nucleus_morphology4.65219616
5MP0003077_abnormal_cell_cycle4.27021030
6MP0008057_abnormal_DNA_replication4.01812840
7MP0008058_abnormal_DNA_repair3.81948137
8MP0008007_abnormal_cellular_replicative3.24074474
9MP0002396_abnormal_hematopoietic_system2.96522503
10MP0008932_abnormal_embryonic_tissue2.89167987
11MP0003123_paternal_imprinting2.50833863
12MP0001730_embryonic_growth_arrest2.37863510
13MP0000350_abnormal_cell_proliferation2.27725342
14MP0008877_abnormal_DNA_methylation2.21194048
15MP0003786_premature_aging2.03735483
16MP0000490_abnormal_crypts_of1.99394861
17MP0010352_gastrointestinal_tract_polyps1.88383451
18MP0003806_abnormal_nucleotide_metabolis1.83939074
19MP0004808_abnormal_hematopoietic_stem1.76467642
20MP0001697_abnormal_embryo_size1.73299856
21MP0005380_embryogenesis_phenotype1.69183672
22MP0001672_abnormal_embryogenesis/_devel1.69183672
23MP0002080_prenatal_lethality1.66514458
24MP0010307_abnormal_tumor_latency1.62746098
25MP0000313_abnormal_cell_death1.58842978
26MP0003984_embryonic_growth_retardation1.53708677
27MP0003718_maternal_effect1.53207642
28MP0005397_hematopoietic_system_phenotyp1.51442250
29MP0001545_abnormal_hematopoietic_system1.51442250
30MP0002019_abnormal_tumor_incidence1.49611654
31MP0002088_abnormal_embryonic_growth/wei1.49077214
32MP0002085_abnormal_embryonic_tissue1.44379905
33MP0003937_abnormal_limbs/digits/tail_de1.43727910
34MP0009333_abnormal_splenocyte_physiolog1.39591898
35MP0002084_abnormal_developmental_patter1.35303862
36MP0003763_abnormal_thymus_physiology1.35075383
37MP0003567_abnormal_fetal_cardiomyocyte1.33583548
38MP0006292_abnormal_olfactory_placode1.33504451
39MP0008789_abnormal_olfactory_epithelium1.32820933
40MP0001293_anophthalmia1.32803470
41MP0002086_abnormal_extraembryonic_tissu1.30047279
42MP0004197_abnormal_fetal_growth/weight/1.26885050
43MP0003315_abnormal_perineum_morphology1.24320469
44MP0004133_heterotaxia1.21994440
45MP0002697_abnormal_eye_size1.21004390
46MP0003121_genomic_imprinting1.19370752
47MP0000703_abnormal_thymus_morphology1.19129092
48MP0002210_abnormal_sex_determination1.19080659
49MP0010030_abnormal_orbit_morphology1.18105035
50MP0002398_abnormal_bone_marrow1.17987879
51MP0005075_abnormal_melanosome_morpholog1.16755261
52MP0006054_spinal_hemorrhage1.15185377
53MP0001346_abnormal_lacrimal_gland1.14964105
54MP0002722_abnormal_immune_system1.12557527
55MP0000358_abnormal_cell_content/1.12212479
56MP0003186_abnormal_redox_activity1.10342069
57MP0000689_abnormal_spleen_morphology1.09038873
58MP0002132_abnormal_respiratory_system1.08693431
59MP0003890_abnormal_embryonic-extraembry1.06613349
60MP0005501_abnormal_skin_physiology1.05407926
61MP0001145_abnormal_male_reproductive1.05314963
62MP0005623_abnormal_meninges_morphology1.03210933
63MP0000566_synostosis1.03169086
64MP0000579_abnormal_nail_morphology1.00092256
65MP0001529_abnormal_vocalization0.97144931
66MP0002160_abnormal_reproductive_system0.96784121
67MP0006035_abnormal_mitochondrial_morpho0.95946636
68MP0004233_abnormal_muscle_weight0.95928238
69MP0005394_taste/olfaction_phenotype0.94438456
70MP0005499_abnormal_olfactory_system0.94438456
71MP0006036_abnormal_mitochondrial_physio0.94375053
72MP0002233_abnormal_nose_morphology0.93789749
73MP0002429_abnormal_blood_cell0.92820381
74MP0003136_yellow_coat_color0.92139227
75MP0001929_abnormal_gametogenesis0.90739290
76MP0001188_hyperpigmentation0.90581425
77MP0001661_extended_life_span0.89908408
78MP0004147_increased_porphyrin_level0.88759562
79MP0000653_abnormal_sex_gland0.88190834
80MP0001853_heart_inflammation0.87060611
81MP0002095_abnormal_skin_pigmentation0.86099339
82MP0002877_abnormal_melanocyte_morpholog0.85869853
83MP0005174_abnormal_tail_pigmentation0.82107056
84MP0003861_abnormal_nervous_system0.81870580
85MP0003119_abnormal_digestive_system0.79291358
86MP0005384_cellular_phenotype0.79204296
87MP0003221_abnormal_cardiomyocyte_apopto0.78897724
88MP0009703_decreased_birth_body0.78794467
89MP0002796_impaired_skin_barrier0.76286749
90MP0009053_abnormal_anal_canal0.75519772
91MP0000537_abnormal_urethra_morphology0.75224052
92MP0000762_abnormal_tongue_morphology0.75142576
93MP0000716_abnormal_immune_system0.74669732
94MP0000858_altered_metastatic_potential0.74582262
95MP0003698_abnormal_male_reproductive0.74399733
96MP0002163_abnormal_gland_morphology0.74281460
97MP0001119_abnormal_female_reproductive0.73232036
98MP0005389_reproductive_system_phenotype0.72933434
99MP0009379_abnormal_foot_pigmentation0.72166869
100MP0000678_abnormal_parathyroid_gland0.70227807
101MP0001727_abnormal_embryo_implantation0.69871146
102MP0002938_white_spotting0.68748465
103MP0002075_abnormal_coat/hair_pigmentati0.68685063
104MP0003942_abnormal_urinary_system0.68240053
105MP0005266_abnormal_metabolism0.68170354
106MP0009672_abnormal_birth_weight0.68117527
107MP0002161_abnormal_fertility/fecundity0.67735036
108MP0005621_abnormal_cell_physiology0.67676798
109MP0008995_early_reproductive_senescence0.67019948
110MP0000647_abnormal_sebaceous_gland0.66656231
111MP0002102_abnormal_ear_morphology0.65609915
112MP0000477_abnormal_intestine_morphology0.64983752
113MP0002111_abnormal_tail_morphology0.64912417
114MP0005187_abnormal_penis_morphology0.64886208
115MP0003755_abnormal_palate_morphology0.64441642
116MP0010234_abnormal_vibrissa_follicle0.63840737
117MP0003699_abnormal_female_reproductive0.63198512
118MP0002234_abnormal_pharynx_morphology0.62893367
119MP0002653_abnormal_ependyma_morphology0.62747349
120MP0006072_abnormal_retinal_apoptosis0.62175999
121MP0001881_abnormal_mammary_gland0.61739878
122MP0003941_abnormal_skin_development0.59964535
123MP0001915_intracranial_hemorrhage0.57998824
124MP0009697_abnormal_copulation0.56974520
125MP0005023_abnormal_wound_healing0.56279336
126MP0000371_diluted_coat_color0.54720549
127MP0000015_abnormal_ear_pigmentation0.53756611
128MP0000049_abnormal_middle_ear0.53086205
129MP0001764_abnormal_homeostasis0.52830071
130MP0001186_pigmentation_phenotype0.50759065
131MP0005671_abnormal_response_to0.50354770
132MP0003943_abnormal_hepatobiliary_system0.50346474
133MP0001286_abnormal_eye_development0.50255796
134MP0003878_abnormal_ear_physiology0.49900949
135MP0005377_hearing/vestibular/ear_phenot0.49900949
136MP0002092_abnormal_eye_morphology0.48937454
137MP0000428_abnormal_craniofacial_morphol0.48762967

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.11426679
2Birth length less than 3rd percentile (HP:0003561)4.99697250
3Abnormal number of erythroid precursors (HP:0012131)4.95542499
4Reticulocytopenia (HP:0001896)4.50243867
5Aplastic anemia (HP:0001915)4.45622658
6Breast hypoplasia (HP:0003187)3.77884555
7Colon cancer (HP:0003003)3.71674063
8Oral leukoplakia (HP:0002745)3.70229664
9Cerebral hypomyelination (HP:0006808)3.47462160
10Medulloblastoma (HP:0002885)3.37602354
11Selective tooth agenesis (HP:0001592)3.31965469
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.27476030
13Chromsome breakage (HP:0040012)3.18133502
14Rough bone trabeculation (HP:0100670)3.17961642
15Macrocytic anemia (HP:0001972)3.17918840
16Degeneration of anterior horn cells (HP:0002398)3.16340598
17Abnormality of the anterior horn cell (HP:0006802)3.16340598
18Carpal bone hypoplasia (HP:0001498)3.09345507
19Patellar aplasia (HP:0006443)3.08438463
20Pallor (HP:0000980)2.97920905
21Ependymoma (HP:0002888)2.97480832
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96674165
23Agnosia (HP:0010524)2.94366261
24Aplasia/Hypoplasia of the patella (HP:0006498)2.89115647
25Thrombocytosis (HP:0001894)2.82077121
26Myelodysplasia (HP:0002863)2.81227203
27Abnormality of the preputium (HP:0100587)2.78499584
28Microretrognathia (HP:0000308)2.76245819
29Meckel diverticulum (HP:0002245)2.74983715
30Chronic bronchitis (HP:0004469)2.72911312
31Premature graying of hair (HP:0002216)2.68128288
32Abnormality of the ileum (HP:0001549)2.67977963
33Absent thumb (HP:0009777)2.66973900
34Supernumerary spleens (HP:0009799)2.63695778
35Acute necrotizing encephalopathy (HP:0006965)2.63614015
36Abnormality of chromosome stability (HP:0003220)2.61587649
37Abnormal mitochondria in muscle tissue (HP:0008316)2.60033491
38Acute encephalopathy (HP:0006846)2.58318576
3911 pairs of ribs (HP:0000878)2.54230339
40Abnormal respiratory motile cilium physiology (HP:0012261)2.48638907
41Neoplasm of the pancreas (HP:0002894)2.47546684
42Rhabdomyosarcoma (HP:0002859)2.45554605
43Bone marrow hypocellularity (HP:0005528)2.44497873
44Basal cell carcinoma (HP:0002671)2.44241428
45Abnormal lung lobation (HP:0002101)2.44166624
46Increased hepatocellular lipid droplets (HP:0006565)2.43270661
47Premature ovarian failure (HP:0008209)2.41113611
48Rhinitis (HP:0012384)2.40165896
49Pancytopenia (HP:0001876)2.38726032
50Cellular immunodeficiency (HP:0005374)2.38207710
51Type I transferrin isoform profile (HP:0003642)2.36981797
52Trismus (HP:0000211)2.36930671
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.36263409
54Multiple enchondromatosis (HP:0005701)2.35072605
55Duodenal stenosis (HP:0100867)2.34243409
56Small intestinal stenosis (HP:0012848)2.34243409
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31488121
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31488121
59Abnormal number of incisors (HP:0011064)2.30705732
60Lipid accumulation in hepatocytes (HP:0006561)2.27476289
61Increased serum lactate (HP:0002151)2.26782839
62Muscle fiber atrophy (HP:0100295)2.26544631
63Amaurosis fugax (HP:0100576)2.24380258
64Mitochondrial inheritance (HP:0001427)2.24195347
65Abnormal trabecular bone morphology (HP:0100671)2.21408727
66Absent radius (HP:0003974)2.20946834
67IgM deficiency (HP:0002850)2.20413801
68Sloping forehead (HP:0000340)2.20194155
69Abnormal respiratory motile cilium morphology (HP:0005938)2.20062183
70Abnormal respiratory epithelium morphology (HP:0012253)2.20062183
71Secondary amenorrhea (HP:0000869)2.16620818
72Type 2 muscle fiber atrophy (HP:0003554)2.15267377
73Abnormality of the heme biosynthetic pathway (HP:0010472)2.14523820
74CNS hypomyelination (HP:0003429)2.12546163
75Cerebral edema (HP:0002181)2.12060157
76Lymphoma (HP:0002665)2.11880612
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08196950
78Cleft eyelid (HP:0000625)2.06400059
79Horseshoe kidney (HP:0000085)2.06239138
80Impulsivity (HP:0100710)2.05822127
81Microvesicular hepatic steatosis (HP:0001414)2.04833475
82Aplasia involving forearm bones (HP:0009822)2.02505024
83Absent forearm bone (HP:0003953)2.02505024
84Tracheoesophageal fistula (HP:0002575)2.02104608
85Increased serum pyruvate (HP:0003542)2.01968162
86Abnormality of glycolysis (HP:0004366)2.01968162
87Atresia of the external auditory canal (HP:0000413)2.01447319
88Abnormality of the umbilical cord (HP:0010881)2.00657914
89Abnormality of the fetal cardiovascular system (HP:0010948)2.00635629
90Abnormal umbilical cord blood vessels (HP:0011403)2.00635629
91Single umbilical artery (HP:0001195)2.00635629
92Nephroblastoma (Wilms tumor) (HP:0002667)2.00627541
93Squamous cell carcinoma (HP:0002860)2.00063468
94Postnatal microcephaly (HP:0005484)1.99447276
95Abnormal ciliary motility (HP:0012262)1.99069238
96Broad distal phalanx of finger (HP:0009836)1.98746134
97Triphalangeal thumb (HP:0001199)1.98459236
98Atrophy/Degeneration involving motor neurons (HP:0007373)1.96984902
99Glossoptosis (HP:0000162)1.96930770
100Progressive muscle weakness (HP:0003323)1.96646683
101Proximal placement of thumb (HP:0009623)1.96259095
102Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94912563
103Abnormality of the labia minora (HP:0012880)1.94878411
104Abnormality of the duodenum (HP:0002246)1.94402446
105Lactic acidosis (HP:0003128)1.93356475
106Abnormality of the carotid arteries (HP:0005344)1.93151771
107Hepatic necrosis (HP:0002605)1.92559451
108Megaloblastic anemia (HP:0001889)1.90284849
109Cortical dysplasia (HP:0002539)1.88791242
110Hepatocellular necrosis (HP:0001404)1.87805439
111Neoplasm of the colon (HP:0100273)1.87649357
112Testicular atrophy (HP:0000029)1.86070325
113Asplenia (HP:0001746)1.85891107
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85754285
115Embryonal renal neoplasm (HP:0011794)1.85533084
116Progressive macrocephaly (HP:0004481)1.85292798
117Facial cleft (HP:0002006)1.83694317
118Exercise intolerance (HP:0003546)1.83465740
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82430791
120Abnormality of alanine metabolism (HP:0010916)1.82430791
121Hyperalaninemia (HP:0003348)1.82430791
122Abnormal protein glycosylation (HP:0012346)1.81601130
123Abnormal glycosylation (HP:0012345)1.81601130
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81601130
125Abnormal protein N-linked glycosylation (HP:0012347)1.81601130
126Deviation of the thumb (HP:0009603)1.81543549
127Sparse eyelashes (HP:0000653)1.80519639
128Poor head control (HP:0002421)1.78570392
129Slender long bone (HP:0003100)1.77848527
130Hypoplasia of the radius (HP:0002984)1.77812130
131Spastic diplegia (HP:0001264)1.76542364
1323-Methylglutaconic aciduria (HP:0003535)1.76034762
133Ectopic kidney (HP:0000086)1.75004140
134Preaxial hand polydactyly (HP:0001177)1.74301609
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.73846941
136Absent/shortened dynein arms (HP:0200106)1.73846941
137Neoplasm of the oral cavity (HP:0100649)1.73610341
138Increased nuchal translucency (HP:0010880)1.73124408
139Increased CSF lactate (HP:0002490)1.72462184
140Optic nerve coloboma (HP:0000588)1.72353978
141Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71421601
142Increased intramyocellular lipid droplets (HP:0012240)1.69801722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.32367190
2WEE14.51769849
3CDC73.84746162
4VRK23.57791363
5EIF2AK13.41669754
6PBK3.23007969
7TSSK62.84873196
8STK162.74137465
9NEK22.50219965
10SRPK12.50031264
11NME22.42226308
12PLK42.35078903
13ACVR1B2.27785663
14NEK12.20607436
15EIF2AK32.20561418
16SMG12.04030837
17BRSK22.00883569
18VRK11.96005047
19MST41.88303503
20TTK1.87942709
21MKNK11.87314339
22PLK11.85984976
23CDK71.68779508
24TGFBR11.68537052
25PASK1.67614675
26RPS6KB21.67430951
27ATR1.61717572
28DYRK31.59278478
29AURKB1.57440325
30TLK11.54014918
31TAF11.49261999
32TESK21.48015656
33PLK31.45343735
34CCNB11.43239811
35RPS6KA41.34015766
36AURKA1.31905226
37BRSK11.27074114
38CHEK21.26500452
39SCYL21.26189561
40CDK41.24468341
41MKNK21.23194766
42PAK41.21064571
43FLT31.16396624
44EEF2K1.14673547
45MAP3K81.13739704
46CDK81.11666616
47KDR1.10718294
48PDK21.09316273
49NUAK11.07471237
50CHEK11.05056979
51PIM21.00368667
52TRIM280.99140846
53STK100.93481393
54BCKDK0.92017878
55MAP3K110.90645270
56MAP4K10.90391558
57EPHA20.89962329
58ZAK0.89309721
59CDK190.87628257
60MAP2K30.87031361
61MST1R0.84521100
62CSNK2A20.79027223
63STK40.77261107
64ERBB40.76488645
65CDK20.73323879
66CSNK2A10.71256192
67ATM0.70655077
68CSNK1G30.67941268
69PIM10.67618784
70PAK10.67238839
71BTK0.65848679
72BRAF0.65372717
73TAOK20.65177965
74EIF2AK20.63287973
75CSNK1G10.61683370
76LRRK20.60855119
77MAP3K100.59734465
78BCR0.59464448
79DAPK10.57937744
80CDK120.57928823
81ZAP700.56317535
82PRKCI0.55959812
83MAPKAPK30.55457116
84CLK10.52645281
85TEC0.52127990
86LIMK10.51498705
87MAPK150.50958752
88KIT0.50008858
89CSNK1A1L0.49251370
90PKN20.48873974
91CDK10.47907125
92PNCK0.47785321
93TESK10.45514297
94ALK0.45489748
95MET0.44410191
96PDK40.43580238
97PDK30.43580238
98AKT20.40005211
99ILK0.39675515
100CSNK1G20.39171032
101MAPKAPK50.38802626
102NME10.38777683
103RPS6KA50.37858763
104CDK90.37561689
105IRAK30.34342791
106CSF1R0.34096753
107MELK0.32382329
108GRK60.32243877
109CDK11A0.31618605
110CDK60.30684450
111DYRK20.29802425
112MAP2K60.28949068
113BLK0.28770361
114CSNK1E0.28454109
115CDK180.28295132
116AKT30.28112907
117BRD40.28011468
118ICK0.27610335
119CDK150.27089206
120ARAF0.26901747
121CDK140.26659312
122JAK30.25518628
123MAP2K70.24661237
124RAF10.24134006
125PRKDC0.22875399
126TXK0.18720740
127RPS6KB10.18280455
128FGFR10.17690715
129LYN0.17289918

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.11287632
2Mismatch repair_Homo sapiens_hsa034304.30830403
3Ribosome_Homo sapiens_hsa030103.90999944
4Proteasome_Homo sapiens_hsa030503.85027844
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.79553559
6RNA polymerase_Homo sapiens_hsa030203.49267079
7Spliceosome_Homo sapiens_hsa030403.38894970
8Base excision repair_Homo sapiens_hsa034103.14349908
9RNA transport_Homo sapiens_hsa030133.12498134
10Homologous recombination_Homo sapiens_hsa034402.95790825
11Nucleotide excision repair_Homo sapiens_hsa034202.88514576
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.69449472
13Pyrimidine metabolism_Homo sapiens_hsa002402.68027248
14Cell cycle_Homo sapiens_hsa041102.50761465
15One carbon pool by folate_Homo sapiens_hsa006702.48794849
16Fanconi anemia pathway_Homo sapiens_hsa034601.99027760
17Non-homologous end-joining_Homo sapiens_hsa034501.98879782
18RNA degradation_Homo sapiens_hsa030181.94452603
19Basal transcription factors_Homo sapiens_hsa030221.91565004
20mRNA surveillance pathway_Homo sapiens_hsa030151.52933518
21Purine metabolism_Homo sapiens_hsa002301.49975986
22p53 signaling pathway_Homo sapiens_hsa041151.35276497
23Epstein-Barr virus infection_Homo sapiens_hsa051691.21687598
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17252626
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16294104
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.09937472
27Fatty acid elongation_Homo sapiens_hsa000621.04556692
28Folate biosynthesis_Homo sapiens_hsa007901.01547741
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97728353
30Biosynthesis of amino acids_Homo sapiens_hsa012300.96541338
31Systemic lupus erythematosus_Homo sapiens_hsa053220.95402930
32Pentose phosphate pathway_Homo sapiens_hsa000300.94412638
33Steroid biosynthesis_Homo sapiens_hsa001000.89876800
34Sulfur relay system_Homo sapiens_hsa041220.89576495
35Protein export_Homo sapiens_hsa030600.88631628
36Propanoate metabolism_Homo sapiens_hsa006400.88330941
37Antigen processing and presentation_Homo sapiens_hsa046120.88000023
38Vitamin B6 metabolism_Homo sapiens_hsa007500.84805945
39Oocyte meiosis_Homo sapiens_hsa041140.83014496
40Herpes simplex infection_Homo sapiens_hsa051680.81674108
41Viral carcinogenesis_Homo sapiens_hsa052030.78861522
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78528213
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.77434004
44Huntingtons disease_Homo sapiens_hsa050160.76771061
45Thyroid cancer_Homo sapiens_hsa052160.72652440
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72505035
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71254595
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70094170
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69784269
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.69414783
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68564275
52Selenocompound metabolism_Homo sapiens_hsa004500.66904776
53Parkinsons disease_Homo sapiens_hsa050120.66652051
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61156940
55HTLV-I infection_Homo sapiens_hsa051660.59596858
56Carbon metabolism_Homo sapiens_hsa012000.57063135
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56708274
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56446232
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56229418
60Primary immunodeficiency_Homo sapiens_hsa053400.55309014
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54607677
62N-Glycan biosynthesis_Homo sapiens_hsa005100.51897259
63Glutathione metabolism_Homo sapiens_hsa004800.51565913
64Legionellosis_Homo sapiens_hsa051340.50357619
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49516807
66Fructose and mannose metabolism_Homo sapiens_hsa000510.48388874
67Phenylalanine metabolism_Homo sapiens_hsa003600.45470218
68Oxidative phosphorylation_Homo sapiens_hsa001900.45207722
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44750388
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41224611
71Lysine degradation_Homo sapiens_hsa003100.40603190
72beta-Alanine metabolism_Homo sapiens_hsa004100.39592739
73Galactose metabolism_Homo sapiens_hsa000520.38452634
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37087834
75Cardiac muscle contraction_Homo sapiens_hsa042600.36222040
76Fatty acid metabolism_Homo sapiens_hsa012120.35728495
77Shigellosis_Homo sapiens_hsa051310.33893012
78Tyrosine metabolism_Homo sapiens_hsa003500.33415161
79Alcoholism_Homo sapiens_hsa050340.32472786
80Apoptosis_Homo sapiens_hsa042100.31835067
81Small cell lung cancer_Homo sapiens_hsa052220.31521302
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31463349
83Metabolic pathways_Homo sapiens_hsa011000.28952473
84Measles_Homo sapiens_hsa051620.27878317
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27784609
86MicroRNAs in cancer_Homo sapiens_hsa052060.27529041
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26625396
88Colorectal cancer_Homo sapiens_hsa052100.25740777
89Peroxisome_Homo sapiens_hsa041460.22697101
90HIF-1 signaling pathway_Homo sapiens_hsa040660.21386463
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21046633
92Hedgehog signaling pathway_Homo sapiens_hsa043400.20616981
93Notch signaling pathway_Homo sapiens_hsa043300.20544577
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.20374469
95TGF-beta signaling pathway_Homo sapiens_hsa043500.20019955
96Bladder cancer_Homo sapiens_hsa052190.19939880
97Acute myeloid leukemia_Homo sapiens_hsa052210.19876177
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19122085
99Hepatitis B_Homo sapiens_hsa051610.18927720
100Basal cell carcinoma_Homo sapiens_hsa052170.18715779
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18101938
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16155448
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16080249
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14877986
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14845315
106* Wnt signaling pathway_Homo sapiens_hsa043100.14539837
107Pathways in cancer_Homo sapiens_hsa052000.13354168
108Hippo signaling pathway_Homo sapiens_hsa043900.12909591
109Tight junction_Homo sapiens_hsa045300.12838986
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.11227256
111Hematopoietic cell lineage_Homo sapiens_hsa046400.11193320
112Arginine biosynthesis_Homo sapiens_hsa002200.11087385
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10891776
114Renin-angiotensin system_Homo sapiens_hsa046140.10122702
115Influenza A_Homo sapiens_hsa051640.10100240
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.09552947
117Fatty acid degradation_Homo sapiens_hsa000710.08706204
118Alzheimers disease_Homo sapiens_hsa050100.08008327
119Arachidonic acid metabolism_Homo sapiens_hsa005900.07834006
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06508581
121Chronic myeloid leukemia_Homo sapiens_hsa052200.04606559
122Pyruvate metabolism_Homo sapiens_hsa006200.04266373
123Asthma_Homo sapiens_hsa053100.02676809
124Arginine and proline metabolism_Homo sapiens_hsa003300.02465417

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