RWDD2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.25877601
2neuron cell-cell adhesion (GO:0007158)5.18257040
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.10130320
4vocalization behavior (GO:0071625)4.81761442
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.72566064
6ATP synthesis coupled proton transport (GO:0015986)4.72566064
7energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.65221738
8ATP hydrolysis coupled proton transport (GO:0015991)4.65221738
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.64713398
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.63024303
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.62045625
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.56359621
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.39271359
14regulation of glutamate receptor signaling pathway (GO:1900449)4.38282227
15branched-chain amino acid catabolic process (GO:0009083)4.35380814
16protein localization to synapse (GO:0035418)4.29057931
17gamma-aminobutyric acid signaling pathway (GO:0007214)4.23121274
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.16434912
19neuronal action potential propagation (GO:0019227)4.13539856
20regulation of synaptic vesicle exocytosis (GO:2000300)4.09913201
21regulation of protein kinase A signaling (GO:0010738)4.08488866
22transferrin transport (GO:0033572)4.02758462
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.02199016
24neurotransmitter secretion (GO:0007269)3.98077613
25respiratory electron transport chain (GO:0022904)3.95497464
26neuron-neuron synaptic transmission (GO:0007270)3.95114600
27chaperone-mediated protein transport (GO:0072321)3.92771047
28glutamate receptor signaling pathway (GO:0007215)3.91126662
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.89939924
30glutamate secretion (GO:0014047)3.89602241
31electron transport chain (GO:0022900)3.87753279
32presynaptic membrane assembly (GO:0097105)3.87269602
33regulation of glutamate secretion (GO:0014048)3.85941513
34response to histamine (GO:0034776)3.76060063
35trivalent inorganic cation transport (GO:0072512)3.73704547
36ferric iron transport (GO:0015682)3.73704547
37fucose catabolic process (GO:0019317)3.70427304
38L-fucose metabolic process (GO:0042354)3.70427304
39L-fucose catabolic process (GO:0042355)3.70427304
40regulation of synaptic vesicle transport (GO:1902803)3.70209648
41presynaptic membrane organization (GO:0097090)3.68022635
42water-soluble vitamin biosynthetic process (GO:0042364)3.65882644
43neuron recognition (GO:0008038)3.65696047
44synaptic transmission, glutamatergic (GO:0035249)3.61398824
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.58467134
46neurotransmitter transport (GO:0006836)3.57125280
47DNA double-strand break processing (GO:0000729)3.54781035
48positive regulation of synaptic transmission, GABAergic (GO:0032230)3.51958048
49positive regulation of synapse assembly (GO:0051965)3.49064969
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.46983644
51valine metabolic process (GO:0006573)3.46382366
52protein localization to cilium (GO:0061512)3.46062340
53synaptic transmission, dopaminergic (GO:0001963)3.44412581
54female mating behavior (GO:0060180)3.43694669
55neuromuscular process controlling posture (GO:0050884)3.42802289
56exploration behavior (GO:0035640)3.37387011
57transmission of nerve impulse (GO:0019226)3.35979290
58branched-chain amino acid metabolic process (GO:0009081)3.35039514
59regulation of neurotransmitter levels (GO:0001505)3.34370591
60inner mitochondrial membrane organization (GO:0007007)3.32922846
61cellular ketone body metabolic process (GO:0046950)3.32825469
62negative regulation of neurotransmitter transport (GO:0051589)3.31920874
63locomotory exploration behavior (GO:0035641)3.31489941
64startle response (GO:0001964)3.30206609
65synaptic vesicle maturation (GO:0016188)3.27183841
66regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.26437219
67regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.26437219
68hydrogen ion transmembrane transport (GO:1902600)3.23357628
69proline transport (GO:0015824)3.21995238
70regulation of vesicle fusion (GO:0031338)3.20966753
71positive regulation of mitochondrial fission (GO:0090141)3.20791579
72phagosome maturation (GO:0090382)3.19586550
73synaptic vesicle endocytosis (GO:0048488)3.19379212
74intraciliary transport (GO:0042073)3.18848060
75calcium ion-dependent exocytosis (GO:0017156)3.18747810
76postsynaptic membrane organization (GO:0001941)3.18087690
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.16693395
78C4-dicarboxylate transport (GO:0015740)3.16400157
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16224711
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.13808067
81behavioral response to cocaine (GO:0048148)3.12635553
82regulation of female receptivity (GO:0045924)3.12078789
83regulation of excitatory postsynaptic membrane potential (GO:0060079)3.10548594
84regulation of synaptic transmission, dopaminergic (GO:0032225)3.10310879
85regulation of long-term neuronal synaptic plasticity (GO:0048169)3.10052396
86behavioral response to nicotine (GO:0035095)3.08276990
87mannosylation (GO:0097502)3.08141643
88L-methionine biosynthetic process (GO:0071265)3.07369601
89amino acid salvage (GO:0043102)3.07369601
90L-methionine salvage (GO:0071267)3.07369601
91behavioral fear response (GO:0001662)3.06435936
92behavioral defense response (GO:0002209)3.06435936
93long-term synaptic potentiation (GO:0060291)3.05865894
94nonmotile primary cilium assembly (GO:0035058)3.05422425
95regulation of postsynaptic membrane potential (GO:0060078)3.03872963
96cysteine metabolic process (GO:0006534)3.03599037
97platelet dense granule organization (GO:0060155)3.03507556
98long-term memory (GO:0007616)3.02505741
99adult feeding behavior (GO:0008343)3.02275689
100long-chain fatty acid biosynthetic process (GO:0042759)3.01378469
101protein-cofactor linkage (GO:0018065)3.01126949
102neurotransmitter uptake (GO:0001504)2.99118982
103gamma-aminobutyric acid transport (GO:0015812)2.97940677
104neurotransmitter-gated ion channel clustering (GO:0072578)2.97567445
105dopamine transport (GO:0015872)2.96921852
106regulation of neurotransmitter uptake (GO:0051580)2.95774145
107regulation of synaptic transmission, GABAergic (GO:0032228)2.95708480
108regulation of neuronal synaptic plasticity (GO:0048168)2.95177010
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94661636
110synaptic vesicle transport (GO:0048489)2.92705718
111establishment of synaptic vesicle localization (GO:0097480)2.92705718
112regulation of catecholamine metabolic process (GO:0042069)2.92212341
113regulation of dopamine metabolic process (GO:0042053)2.92212341
114fear response (GO:0042596)2.90690967
115positive regulation of membrane potential (GO:0045838)2.90375611
116social behavior (GO:0035176)2.90166764
117intraspecies interaction between organisms (GO:0051703)2.90166764
118ATP biosynthetic process (GO:0006754)2.90135948
119regulation of synaptic transmission, glutamatergic (GO:0051966)2.90121498
120opioid receptor signaling pathway (GO:0038003)2.89493873
121ketone body metabolic process (GO:1902224)2.88761279
122synaptic transmission (GO:0007268)2.85158641
123proton transport (GO:0015992)2.84661751
124regulation of nuclear cell cycle DNA replication (GO:0033262)2.84367548
125cullin deneddylation (GO:0010388)2.83338552
126peptidyl-histidine modification (GO:0018202)2.83278372
127protein neddylation (GO:0045116)2.81140727
128glycerophospholipid catabolic process (GO:0046475)2.78192866
129respiratory chain complex IV assembly (GO:0008535)2.72069308
130response to pheromone (GO:0019236)2.69467095
131proteasome assembly (GO:0043248)2.59997140
132synapsis (GO:0007129)2.57427371
133protein complex biogenesis (GO:0070271)2.57179918
134cilium morphogenesis (GO:0060271)2.56896278
135detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56700900
136retinal ganglion cell axon guidance (GO:0031290)2.54914105
137preassembly of GPI anchor in ER membrane (GO:0016254)2.53497082
138mitochondrial respiratory chain complex I assembly (GO:0032981)2.53090656
139NADH dehydrogenase complex assembly (GO:0010257)2.53090656
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53090656
141chromatin remodeling at centromere (GO:0031055)2.49685842
142detection of light stimulus involved in sensory perception (GO:0050962)2.49182844
143detection of light stimulus involved in visual perception (GO:0050908)2.49182844
144lactate metabolic process (GO:0006089)2.48771696
145regulation of glucokinase activity (GO:0033131)2.47376473
146regulation of hexokinase activity (GO:1903299)2.47376473
147photoreceptor cell maintenance (GO:0045494)2.47224302
148response to nitrosative stress (GO:0051409)2.46662980
149protein K6-linked ubiquitination (GO:0085020)2.46590662
150protein deneddylation (GO:0000338)2.45439468
151negative regulation of DNA-dependent DNA replication (GO:2000104)2.43063010
152CENP-A containing nucleosome assembly (GO:0034080)2.42537875
153positive regulation of meiosis (GO:0045836)2.41463523
154male meiosis I (GO:0007141)2.38169844
155detection of calcium ion (GO:0005513)2.38142541
156glycosphingolipid biosynthetic process (GO:0006688)2.36161621
157regulation of cilium movement (GO:0003352)2.31894482
158cytochrome complex assembly (GO:0017004)2.31665881
159sterol biosynthetic process (GO:0016126)2.31160607
160cilium organization (GO:0044782)2.30969438
161mitochondrial respiratory chain complex assembly (GO:0033108)2.29972216
162peptidyl-cysteine modification (GO:0018198)2.29726242
163replication fork processing (GO:0031297)2.29617329
164retinal cone cell development (GO:0046549)2.28536582
165histone exchange (GO:0043486)2.27322572
166cilium assembly (GO:0042384)2.26764962
167positive regulation of meiotic cell cycle (GO:0051446)2.25736408
168metallo-sulfur cluster assembly (GO:0031163)2.25470123
169iron-sulfur cluster assembly (GO:0016226)2.25470123
170neuronal action potential (GO:0019228)2.25255429
171negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.23676201
172negative regulation of translation, ncRNA-mediated (GO:0040033)2.23676201
173regulation of translation, ncRNA-mediated (GO:0045974)2.23676201
174aldehyde catabolic process (GO:0046185)2.23108291
175organelle disassembly (GO:1903008)2.22894286
176DNA methylation involved in gamete generation (GO:0043046)2.22769418
177methionine biosynthetic process (GO:0009086)2.22732669
178axonal fasciculation (GO:0007413)2.22416962
179DNA integration (GO:0015074)2.21359984
180photoreceptor cell development (GO:0042461)2.21289047
181regulation of microtubule-based movement (GO:0060632)2.20669130
182piRNA metabolic process (GO:0034587)2.20300633
183regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.20253919
184negative regulation of cytosolic calcium ion concentration (GO:0051481)2.20252027
185regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.14598045
186membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.13202324
187biotin metabolic process (GO:0006768)2.12725000
188transcription elongation from RNA polymerase III promoter (GO:0006385)2.12318907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22536916
2GBX2_23144817_ChIP-Seq_PC3_Human4.17979358
3TAF15_26573619_Chip-Seq_HEK293_Human3.24743587
4REST_21632747_ChIP-Seq_MESCs_Mouse2.75006181
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71135009
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67334903
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.59518594
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56345569
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.53529235
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.43736407
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42838703
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.38851160
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.37778598
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37009142
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32909984
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21595861
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20004539
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.17016451
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15198230
20VDR_22108803_ChIP-Seq_LS180_Human2.14213680
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10270097
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.09894340
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09560001
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04698317
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03126291
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00367546
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98616950
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97750210
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96813131
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95909125
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95696572
32FUS_26573619_Chip-Seq_HEK293_Human1.95130749
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93370224
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90639306
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90639306
36ZNF274_21170338_ChIP-Seq_K562_Hela1.88834201
37P300_19829295_ChIP-Seq_ESCs_Human1.88496624
38SMAD4_21799915_ChIP-Seq_A2780_Human1.87839723
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87288515
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.86727690
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.75019129
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72592180
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70807779
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70273349
45IGF1R_20145208_ChIP-Seq_DFB_Human1.65893359
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.64535616
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.64224742
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.63331878
49ELK1_19687146_ChIP-ChIP_HELA_Human1.61828974
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.60936157
51RNF2_27304074_Chip-Seq_NSC_Mouse1.60804118
52IRF1_19129219_ChIP-ChIP_H3396_Human1.55604267
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.55455138
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50483200
55ER_23166858_ChIP-Seq_MCF-7_Human1.49684791
56AR_21572438_ChIP-Seq_LNCaP_Human1.49468018
57* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45958188
58MYC_18940864_ChIP-ChIP_HL60_Human1.44469215
59DROSHA_22980978_ChIP-Seq_HELA_Human1.42233322
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42091655
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41539180
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40032977
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39475986
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.37675990
65* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37554551
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36153723
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34819450
68AR_25329375_ChIP-Seq_VCAP_Human1.34013978
69TP53_22573176_ChIP-Seq_HFKS_Human1.33750611
70BCAT_22108803_ChIP-Seq_LS180_Human1.33115926
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30335910
72JUN_21703547_ChIP-Seq_K562_Human1.29725412
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29100190
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.27127768
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25237522
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24927351
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.24211182
78NANOG_19829295_ChIP-Seq_ESCs_Human1.23755754
79SOX2_19829295_ChIP-Seq_ESCs_Human1.23755754
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22144224
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20547864
82TCF4_22108803_ChIP-Seq_LS180_Human1.19222893
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18563444
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.17745336
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16913486
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16773076
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16352891
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.16346299
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.16164634
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13362228
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12205657
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.11626770
93RUNX2_22187159_ChIP-Seq_PCA_Human1.11036383
94TCF4_23295773_ChIP-Seq_U87_Human1.09674039
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09612543
96EWS_26573619_Chip-Seq_HEK293_Human1.09418114
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.09130419
98STAT3_23295773_ChIP-Seq_U87_Human1.09083969
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08761493
100VDR_23849224_ChIP-Seq_CD4+_Human1.08584651
101KDM2B_26808549_Chip-Seq_REH_Human1.08493277
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07940082
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06732810
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06553085
105ETS1_20019798_ChIP-Seq_JURKAT_Human1.06174623
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05724212
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04587303
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04380482
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04331419
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03968643
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03214687
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.02369579
113NOTCH1_21737748_ChIP-Seq_TLL_Human1.01574423
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.00789049
115CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00225132
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00076987
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00049494
118SMAD4_21741376_ChIP-Seq_EPCs_Human1.00006905
119P53_22387025_ChIP-Seq_ESCs_Mouse0.99528826
120CDX2_22108803_ChIP-Seq_LS180_Human0.99081861
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98623953
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98623823
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98365046
124CBP_20019798_ChIP-Seq_JUKART_Human0.98060887
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98060887
126FLI1_21867929_ChIP-Seq_TH2_Mouse0.97004843
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96891811
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96528591
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96528591
130KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96202704
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95898308
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95661324
133PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95342986
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94569924
135JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94096418
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.94007830
137HTT_18923047_ChIP-ChIP_STHdh_Human0.93921557
138SOX9_26525672_Chip-Seq_HEART_Mouse0.93580886
139POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93403972
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.91121953
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91016261
142CMYC_18555785_Chip-Seq_ESCs_Mouse0.90735251
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90016347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.58167471
2MP0004859_abnormal_synaptic_plasticity4.37216578
3MP0003635_abnormal_synaptic_transmissio3.66345220
4MP0009046_muscle_twitch3.44254107
5MP0009745_abnormal_behavioral_response3.24500841
6MP0002064_seizures3.21605475
7MP0001529_abnormal_vocalization3.16148462
8MP0001968_abnormal_touch/_nociception3.15180374
9MP0002736_abnormal_nociception_after3.00736301
10MP0006276_abnormal_autonomic_nervous2.92047988
11MP0002063_abnormal_learning/memory/cond2.91474396
12MP0003122_maternal_imprinting2.83332216
13MP0002572_abnormal_emotion/affect_behav2.82589211
14MP0002102_abnormal_ear_morphology2.82073227
15MP0001440_abnormal_grooming_behavior2.70866895
16MP0002272_abnormal_nervous_system2.69704049
17MP0004270_analgesia2.61793576
18MP0001501_abnormal_sleep_pattern2.54611253
19MP0003195_calcinosis2.33541514
20MP0002734_abnormal_mechanical_nocicepti2.32688831
21MP0002735_abnormal_chemical_nociception2.27417621
22MP0001486_abnormal_startle_reflex2.22885736
23MP0002837_dystrophic_cardiac_calcinosis2.20134316
24MP0005645_abnormal_hypothalamus_physiol2.18381391
25MP0004142_abnormal_muscle_tone2.13776093
26MP0001905_abnormal_dopamine_level2.08224282
27MP0003787_abnormal_imprinting2.06291847
28MP0002067_abnormal_sensory_capabilities2.05277402
29MP0005423_abnormal_somatic_nervous2.00463032
30MP0005410_abnormal_fertilization1.95761285
31MP0003136_yellow_coat_color1.91955133
32MP0001970_abnormal_pain_threshold1.90580111
33MP0008877_abnormal_DNA_methylation1.89065144
34MP0004924_abnormal_behavior1.88678051
35MP0005386_behavior/neurological_phenoty1.88678051
36MP0002733_abnormal_thermal_nociception1.83364844
37MP0001984_abnormal_olfaction1.72815984
38MP0002184_abnormal_innervation1.69294800
39MP0001485_abnormal_pinna_reflex1.67776835
40MP0000516_abnormal_urinary_system1.64988811
41MP0005367_renal/urinary_system_phenotyp1.64988811
42MP0002557_abnormal_social/conspecific_i1.64471411
43MP0005646_abnormal_pituitary_gland1.62069210
44MP0006292_abnormal_olfactory_placode1.57515820
45MP0003329_amyloid_beta_deposits1.55795628
46MP0000778_abnormal_nervous_system1.52686842
47MP0001188_hyperpigmentation1.50289516
48MP0005253_abnormal_eye_physiology1.49935064
49MP0003646_muscle_fatigue1.44792457
50MP0002822_catalepsy1.44343810
51MP0002653_abnormal_ependyma_morphology1.44237956
52MP0004885_abnormal_endolymph1.43538496
53MP0003890_abnormal_embryonic-extraembry1.42110918
54MP0002876_abnormal_thyroid_physiology1.40303259
55MP0003121_genomic_imprinting1.40264222
56MP0005377_hearing/vestibular/ear_phenot1.38487376
57MP0003878_abnormal_ear_physiology1.38487376
58MP0005084_abnormal_gallbladder_morpholo1.36763510
59MP0002066_abnormal_motor_capabilities/c1.36456424
60MP0004811_abnormal_neuron_physiology1.32459939
61MP0003941_abnormal_skin_development1.30572752
62MP0001986_abnormal_taste_sensitivity1.29891281
63MP0000955_abnormal_spinal_cord1.28982007
64MP0008569_lethality_at_weaning1.27853458
65MP0002160_abnormal_reproductive_system1.25682005
66MP0004133_heterotaxia1.25035668
67MP0002882_abnormal_neuron_morphology1.23708378
68MP0003123_paternal_imprinting1.22978449
69MP0003718_maternal_effect1.20922897
70MP0003879_abnormal_hair_cell1.19868567
71MP0003283_abnormal_digestive_organ1.19040987
72MP0005220_abnormal_exocrine_pancreas1.17775588
73MP0002938_white_spotting1.15998160
74MP0002090_abnormal_vision1.15596521
75MP0005187_abnormal_penis_morphology1.15258517
76MP0001502_abnormal_circadian_rhythm1.15228108
77MP0008872_abnormal_physiological_respon1.14172099
78MP0000013_abnormal_adipose_tissue1.13476055
79MP0000751_myopathy1.11193051
80MP0004742_abnormal_vestibular_system1.11135029
81MP0002909_abnormal_adrenal_gland1.09888198
82MP0003567_abnormal_fetal_cardiomyocyte1.05117734
83MP0002229_neurodegeneration1.03699898
84MP0008775_abnormal_heart_ventricle1.03495438
85MP0008789_abnormal_olfactory_epithelium1.02218820
86MP0005551_abnormal_eye_electrophysiolog1.00304670
87MP0006035_abnormal_mitochondrial_morpho0.97239813
88MP0000427_abnormal_hair_cycle0.97143041
89MP0002928_abnormal_bile_duct0.96673056
90MP0005389_reproductive_system_phenotype0.96488101
91MP0005195_abnormal_posterior_eye0.95853809
92MP0003011_delayed_dark_adaptation0.94188562
93MP0004858_abnormal_nervous_system0.94056413
94MP0002152_abnormal_brain_morphology0.94024000
95MP0009780_abnormal_chondrocyte_physiolo0.93977999
96MP0006072_abnormal_retinal_apoptosis0.92906411
97MP0008058_abnormal_DNA_repair0.92471279
98MP0005379_endocrine/exocrine_gland_phen0.92200319
99MP0003633_abnormal_nervous_system0.91983574
100MP0002069_abnormal_eating/drinking_beha0.91832035
101MP0001963_abnormal_hearing_physiology0.91670413
102MP0003937_abnormal_limbs/digits/tail_de0.90207529
103MP0005535_abnormal_body_temperature0.90183762
104MP0003698_abnormal_male_reproductive0.89724046
105MP0000647_abnormal_sebaceous_gland0.89471680
106MP0000631_abnormal_neuroendocrine_gland0.89368124
107MP0004147_increased_porphyrin_level0.88736729
108MP0003137_abnormal_impulse_conducting0.87127630
109MP0001293_anophthalmia0.86769056
110MP0002210_abnormal_sex_determination0.86722062
111MP0004145_abnormal_muscle_electrophysio0.86699737
112MP0003631_nervous_system_phenotype0.86057081
113MP0002332_abnormal_exercise_endurance0.84612987
114MP0005394_taste/olfaction_phenotype0.83427725
115MP0005499_abnormal_olfactory_system0.83427725
116MP0002163_abnormal_gland_morphology0.81078154
117MP0010386_abnormal_urinary_bladder0.79560663
118MP0004233_abnormal_muscle_weight0.79462287
119MP0002752_abnormal_somatic_nervous0.78356804
120MP0001664_abnormal_digestion0.78050908
121MP0009379_abnormal_foot_pigmentation0.77967292
122MP0005409_darkened_coat_color0.74992528
123MP0008874_decreased_physiological_sensi0.73297260
124MP0004484_altered_response_of0.72219355
125MP0003634_abnormal_glial_cell0.71596279
126MP0000604_amyloidosis0.65897180
127MP0006036_abnormal_mitochondrial_physio0.65616949
128MP0004215_abnormal_myocardial_fiber0.65082863
129MP0004085_abnormal_heartbeat0.64759738
130MP0003632_abnormal_nervous_system0.63779757
131MP0004036_abnormal_muscle_relaxation0.63183684
132MP0002638_abnormal_pupillary_reflex0.60751553
133MP0003690_abnormal_glial_cell0.59833934
134MP0001943_abnormal_respiration0.57713968
135MP0000920_abnormal_myelination0.57608923
136MP0000026_abnormal_inner_ear0.57057913
137MP0004043_abnormal_pH_regulation0.56747633
138MP0005171_absent_coat_pigmentation0.51561223
139MP0001929_abnormal_gametogenesis0.50989090

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.98351832
2Visual hallucinations (HP:0002367)5.09830898
3Atonic seizures (HP:0010819)4.98878868
4Focal seizures (HP:0007359)4.58410776
5Acute necrotizing encephalopathy (HP:0006965)4.51443928
6Myokymia (HP:0002411)4.40676406
7Abnormal mitochondria in muscle tissue (HP:0008316)4.19734433
8Absence seizures (HP:0002121)4.10155608
9Progressive macrocephaly (HP:0004481)3.96574542
10Epileptic encephalopathy (HP:0200134)3.92225297
11Mitochondrial inheritance (HP:0001427)3.84396421
12Febrile seizures (HP:0002373)3.82343717
13Dialeptic seizures (HP:0011146)3.73909918
14Polyphagia (HP:0002591)3.62052511
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.59553076
16Absent/shortened dynein arms (HP:0200106)3.59553076
17Abnormal hair whorl (HP:0010721)3.51300451
18Generalized tonic-clonic seizures (HP:0002069)3.48973647
19Acute encephalopathy (HP:0006846)3.46973910
20Pancreatic cysts (HP:0001737)3.46583318
21Progressive cerebellar ataxia (HP:0002073)3.40725190
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.40106913
23True hermaphroditism (HP:0010459)3.36027610
24Pancreatic fibrosis (HP:0100732)3.34174321
25Hyperinsulinemic hypoglycemia (HP:0000825)3.26940470
26Gait imbalance (HP:0002141)3.24701511
27Increased CSF lactate (HP:0002490)3.23211659
28Hyperventilation (HP:0002883)3.20096156
29Type II lissencephaly (HP:0007260)3.18927217
30Abnormal respiratory motile cilium physiology (HP:0012261)3.17287731
31Medial flaring of the eyebrow (HP:0010747)3.11720218
32Abnormal ciliary motility (HP:0012262)3.09637080
33Abnormal eating behavior (HP:0100738)3.02996739
34Congenital primary aphakia (HP:0007707)3.02828229
35Pheochromocytoma (HP:0002666)3.02608564
36Hepatocellular necrosis (HP:0001404)3.02156104
37Nephronophthisis (HP:0000090)3.01007554
38Poor suck (HP:0002033)3.00281976
39Neuroendocrine neoplasm (HP:0100634)2.98277591
40Failure to thrive in infancy (HP:0001531)2.97010993
41Abnormal respiratory motile cilium morphology (HP:0005938)2.95070662
42Abnormal respiratory epithelium morphology (HP:0012253)2.95070662
43Limb dystonia (HP:0002451)2.87962181
44Hypoglycemic coma (HP:0001325)2.83361552
45Abnormality of the labia minora (HP:0012880)2.82393322
46Oligomenorrhea (HP:0000876)2.79002853
47Methylmalonic acidemia (HP:0002912)2.78909953
48Nephrogenic diabetes insipidus (HP:0009806)2.78845170
49Hyperglycinemia (HP:0002154)2.73824169
50Hypoglycemic seizures (HP:0002173)2.71797314
51Broad-based gait (HP:0002136)2.65006460
52Cerebral inclusion bodies (HP:0100314)2.64401393
53Progressive inability to walk (HP:0002505)2.63979983
54Rhinitis (HP:0012384)2.61755407
55Optic disc pallor (HP:0000543)2.59016507
56Anxiety (HP:0000739)2.55071285
57Delusions (HP:0000746)2.54093629
58Abnormality of the renal cortex (HP:0011035)2.52276727
59Abnormality of the renal medulla (HP:0100957)2.50755441
60Ketoacidosis (HP:0001993)2.46242564
61Neurofibrillary tangles (HP:0002185)2.44187312
62Leukodystrophy (HP:0002415)2.43597235
63Abolished electroretinogram (ERG) (HP:0000550)2.41291260
64Impaired vibration sensation in the lower limbs (HP:0002166)2.41273442
65Truncal ataxia (HP:0002078)2.40322379
66Increased hepatocellular lipid droplets (HP:0006565)2.39314084
67Supranuclear gaze palsy (HP:0000605)2.38787257
68Infertility (HP:0000789)2.36967565
69Dysmetria (HP:0001310)2.35172116
70Methylmalonic aciduria (HP:0012120)2.33910135
71Amblyopia (HP:0000646)2.33004632
72Chronic hepatic failure (HP:0100626)2.32135608
73Esotropia (HP:0000565)2.29623334
74Abnormality of alanine metabolism (HP:0010916)2.29475776
75Hyperalaninemia (HP:0003348)2.29475776
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29475776
77Epileptiform EEG discharges (HP:0011182)2.29408039
78Ketosis (HP:0001946)2.29054975
79Gaze-evoked nystagmus (HP:0000640)2.28843524
80Abnormality of binocular vision (HP:0011514)2.27773844
81Diplopia (HP:0000651)2.27773844
82Lissencephaly (HP:0001339)2.27645262
83Cerebellar dysplasia (HP:0007033)2.27579335
84Genital tract atresia (HP:0001827)2.26431941
85Mutism (HP:0002300)2.26055202
86Vaginal atresia (HP:0000148)2.25870923
87Specific learning disability (HP:0001328)2.24526339
88Hypomagnesemia (HP:0002917)2.20269996
89Hyperglycinuria (HP:0003108)2.17668518
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.17573889
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17573889
92Abnormality of glycolysis (HP:0004366)2.15682069
93Increased serum pyruvate (HP:0003542)2.15682069
94Generalized myoclonic seizures (HP:0002123)2.14030193
95Poor coordination (HP:0002370)2.13949941
96EEG with generalized epileptiform discharges (HP:0011198)2.13666230
97Abnormality of serine family amino acid metabolism (HP:0010894)2.13088735
98Abnormality of glycine metabolism (HP:0010895)2.13088735
99Cerebral edema (HP:0002181)2.12933064
100Abnormality of the corticospinal tract (HP:0002492)2.11833050
101Polydipsia (HP:0001959)2.11798069
102Abnormal drinking behavior (HP:0030082)2.11798069
103Occipital encephalocele (HP:0002085)2.11550778
1043-Methylglutaconic aciduria (HP:0003535)2.10669475
105Sensory axonal neuropathy (HP:0003390)2.09642927
106Respiratory failure (HP:0002878)2.08804488
107Cystic liver disease (HP:0006706)2.07537823
108Drooling (HP:0002307)2.06346249
109Excessive salivation (HP:0003781)2.06346249
110Inability to walk (HP:0002540)2.05848043
111Exercise intolerance (HP:0003546)2.04787399
112Depression (HP:0000716)2.04605647
113Molar tooth sign on MRI (HP:0002419)2.03915594
114Abnormality of midbrain morphology (HP:0002418)2.03915594
115Anophthalmia (HP:0000528)2.03787879
116Congenital stationary night blindness (HP:0007642)2.03743519
117Psychosis (HP:0000709)2.02178053
118Dysdiadochokinesis (HP:0002075)2.02113938
119Abnormal biliary tract physiology (HP:0012439)2.02084511
120Bile duct proliferation (HP:0001408)2.02084511
121Renal Fanconi syndrome (HP:0001994)2.01635684
122Sclerocornea (HP:0000647)2.00969557
123Emotional lability (HP:0000712)2.00914396
124Hypsarrhythmia (HP:0002521)2.00781818
125Aplasia/Hypoplasia of the tongue (HP:0010295)2.00496799
126Optic nerve hypoplasia (HP:0000609)2.00330829
127Neoplasm of the adrenal cortex (HP:0100641)1.99276139
128Hypoventilation (HP:0002791)1.98743434
129Lactic acidosis (HP:0003128)1.95521426
130Hepatic necrosis (HP:0002605)1.95300142
131Postaxial hand polydactyly (HP:0001162)1.95228824
132Hemiparesis (HP:0001269)1.94795292
133Delayed gross motor development (HP:0002194)1.94235092
134Renal cortical cysts (HP:0000803)1.92131283
135Lipid accumulation in hepatocytes (HP:0006561)1.91564893
136Bradykinesia (HP:0002067)1.91466609
137Amyotrophic lateral sclerosis (HP:0007354)1.90407206
138Hepatoblastoma (HP:0002884)1.89534925
139X-linked dominant inheritance (HP:0001423)1.88082379
140Anencephaly (HP:0002323)1.87860614
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87858148
142Fetal akinesia sequence (HP:0001989)1.86359351
143Narrow nasal bridge (HP:0000446)1.85952306
144Abnormality of the metopic suture (HP:0005556)1.84432054
145Hypothermia (HP:0002045)1.84294239
146Abnormality of serum amino acid levels (HP:0003112)1.83984323
147Abnormal pancreas size (HP:0012094)1.83033540
148Male pseudohermaphroditism (HP:0000037)1.82009544
149Large for gestational age (HP:0001520)1.81376950
150Abnormal rod and cone electroretinograms (HP:0008323)1.77384934
151Supernumerary spleens (HP:0009799)1.77120883
152Abnormality of urine glucose concentration (HP:0011016)1.76855061
153Glycosuria (HP:0003076)1.76855061
154Double outlet right ventricle (HP:0001719)1.75785256
155Congenital malformation of the right heart (HP:0011723)1.75785256
156Congenital hepatic fibrosis (HP:0002612)1.74569987
157Prominent metopic ridge (HP:0005487)1.72184609
158Lethargy (HP:0001254)1.71060304
159Polyuria (HP:0000103)1.70285139
160Bifid tongue (HP:0010297)1.70168533
161Postaxial foot polydactyly (HP:0001830)1.67855325
162Intestinal atresia (HP:0011100)1.66469872
163Colon cancer (HP:0003003)1.66039876
164Pachygyria (HP:0001302)1.65809804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.00985010
2FRK4.01988238
3NTRK33.94139040
4MAP3K43.55578230
5MAP2K73.36526029
6CASK3.08844490
7PNCK3.02019091
8MAP3K92.90735990
9EPHA42.58233215
10MAP2K42.45558299
11MINK12.38418070
12GRK72.20116115
13ARAF2.20062889
14MAP4K22.18675683
15ZAK2.16901711
16MKNK22.12212406
17NUAK12.09890604
18NME12.09812076
19RIPK42.09614395
20MARK12.09287027
21TRIM282.06110481
22GRK12.04467605
23PINK12.03175479
24PLK21.92712069
25EIF2AK31.92675784
26CDK191.88910758
27ERBB31.84154985
28TNIK1.78522893
29FGFR21.68904664
30PDK31.68137371
31PDK41.68137371
32GRK51.67919694
33NTRK21.59214440
34DAPK11.51114248
35TAOK11.46811717
36OXSR11.44186304
37ACVR1B1.38752270
38STK38L1.36448097
39SRPK11.33471430
40PRKCG1.29984858
41FES1.27406059
42BMPR21.26826400
43CAMK2A1.26524404
44MAPK131.25389819
45BRSK21.24891322
46TSSK61.24591723
47KSR21.17391096
48EIF2AK11.13959711
49MKNK11.13536038
50CDK51.10928237
51CAMK1G1.10370442
52ADRBK21.09949884
53VRK21.08600598
54VRK11.07094662
55CSNK1G11.05677321
56PAK61.04402766
57MUSK1.03148017
58LATS11.02096512
59PTK2B0.99579673
60STK390.99061840
61AKT30.97501702
62CAMK2B0.97001872
63INSRR0.95020710
64KSR10.94770072
65TNK20.93292572
66BRAF0.92568700
67NEK10.92096707
68MAP3K130.91953869
69MYLK0.90741772
70DAPK20.89756764
71PDK20.88994406
72UHMK10.88714582
73FGR0.84798185
74BCR0.83227726
75CDK140.81776286
76MAP3K60.81219786
77DYRK20.80884776
78CDK180.79082455
79LATS20.78473492
80NTRK10.77752033
81CDK150.75531705
82CAMKK20.74874920
83WNK30.74802718
84CDK30.73743778
85CSNK1A1L0.73318128
86ADRBK10.72879311
87PIK3CA0.72042111
88BRSK10.71336611
89EPHA30.69658837
90RAF10.69543793
91PLK40.69312786
92CSNK1G20.68707894
93MAPKAPK50.68473641
94TLK10.68247820
95CAMK2G0.67948069
96CAMK2D0.66953963
97TAF10.65172791
98CDK11A0.64789688
99GRK60.63983308
100STK160.63583715
101WNK40.61913875
102PASK0.61741842
103LIMK10.61275880
104BCKDK0.59685289
105CAMK1D0.59634882
106WEE10.58656006
107STK380.58438663
108DYRK1A0.58213117
109CDC70.56932196
110BRD40.56855960
111SGK4940.56467375
112SGK2230.56467375
113PAK30.56317207
114SIK20.55165276
115CAMK10.54936884
116MOS0.54767828
117PRKCE0.54064490
118CSNK1G30.53021698
119PLK10.51438874
120CCNB10.50643048
121ROCK20.48939780
122CAMKK10.48211500
123TGFBR10.47806176
124ERBB40.46330634
125BMPR1B0.44482913
126STK30.43903379
127PLK30.42201417
128PHKG20.41782242
129PHKG10.41782242
130MAP2K60.40675747
131SGK20.40493195
132PRKACA0.40275671
133PKN10.39335703
134CSNK1A10.39229253
135FLT30.38594407
136SGK10.38166568
137TGFBR20.38096860
138FER0.38019112
139MST40.37710213
140PRKCI0.35890152
141STK110.34738463
142CSNK1D0.34393663
143PRKD30.32900287
144MAP3K10.32297706
145SIK30.30970032
146DAPK30.28741437
147PRKCA0.27286739
148PRKG10.26971329
149CSNK1E0.26868591
150RPS6KA30.26274059
151PDK10.26120937
152PRKCH0.25127494

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.32072301
2Oxidative phosphorylation_Homo sapiens_hsa001904.18994039
3Synaptic vesicle cycle_Homo sapiens_hsa047213.65091721
4Collecting duct acid secretion_Homo sapiens_hsa049663.57564906
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.27720064
6Parkinsons disease_Homo sapiens_hsa050123.20525130
7Propanoate metabolism_Homo sapiens_hsa006402.99333225
8Alzheimers disease_Homo sapiens_hsa050102.75092047
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63939252
10GABAergic synapse_Homo sapiens_hsa047272.51963973
11Long-term potentiation_Homo sapiens_hsa047202.39800947
12Huntingtons disease_Homo sapiens_hsa050162.38851210
13Amphetamine addiction_Homo sapiens_hsa050312.36187534
14Morphine addiction_Homo sapiens_hsa050322.23659777
15Vibrio cholerae infection_Homo sapiens_hsa051102.20750504
16Olfactory transduction_Homo sapiens_hsa047402.17931952
17Circadian entrainment_Homo sapiens_hsa047132.14229192
18Glutamatergic synapse_Homo sapiens_hsa047242.04274997
19Cardiac muscle contraction_Homo sapiens_hsa042601.99388639
20Taste transduction_Homo sapiens_hsa047421.93196651
21Dopaminergic synapse_Homo sapiens_hsa047281.90875614
22Steroid biosynthesis_Homo sapiens_hsa001001.90032852
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.87787195
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87567558
25Sulfur relay system_Homo sapiens_hsa041221.84248523
26Serotonergic synapse_Homo sapiens_hsa047261.82952715
27Basal transcription factors_Homo sapiens_hsa030221.72344638
28Salivary secretion_Homo sapiens_hsa049701.70441179
29Renin secretion_Homo sapiens_hsa049241.69522870
30Long-term depression_Homo sapiens_hsa047301.69152870
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.64226818
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61994894
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59980004
34Fatty acid metabolism_Homo sapiens_hsa012121.54976317
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53188723
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53084136
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50014406
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47413389
39Calcium signaling pathway_Homo sapiens_hsa040201.47179889
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.43113972
41Cocaine addiction_Homo sapiens_hsa050301.42918326
42Insulin secretion_Homo sapiens_hsa049111.39157002
43Gastric acid secretion_Homo sapiens_hsa049711.37132531
44Fatty acid degradation_Homo sapiens_hsa000711.36022181
45Selenocompound metabolism_Homo sapiens_hsa004501.32741415
46Cholinergic synapse_Homo sapiens_hsa047251.29932552
47Tryptophan metabolism_Homo sapiens_hsa003801.29653409
48Peroxisome_Homo sapiens_hsa041461.29641762
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28653637
50Homologous recombination_Homo sapiens_hsa034401.25421091
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25165614
52beta-Alanine metabolism_Homo sapiens_hsa004101.23835549
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22635463
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20381664
55Oxytocin signaling pathway_Homo sapiens_hsa049211.19344335
56Nitrogen metabolism_Homo sapiens_hsa009101.18402752
57Rheumatoid arthritis_Homo sapiens_hsa053231.17407433
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16773262
59Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14713334
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12360008
61Linoleic acid metabolism_Homo sapiens_hsa005911.11619855
62RNA degradation_Homo sapiens_hsa030181.09533487
63Fanconi anemia pathway_Homo sapiens_hsa034601.07240371
64Non-homologous end-joining_Homo sapiens_hsa034501.06492608
65Proteasome_Homo sapiens_hsa030501.04458683
66Phototransduction_Homo sapiens_hsa047441.04411546
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02322250
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00317227
69GnRH signaling pathway_Homo sapiens_hsa049120.99176791
70Gap junction_Homo sapiens_hsa045400.98209971
71Folate biosynthesis_Homo sapiens_hsa007900.93323776
72Oocyte meiosis_Homo sapiens_hsa041140.93291576
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90456543
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89014417
75Pyruvate metabolism_Homo sapiens_hsa006200.86099840
76Chemical carcinogenesis_Homo sapiens_hsa052040.82772133
77Caffeine metabolism_Homo sapiens_hsa002320.81667785
78Nucleotide excision repair_Homo sapiens_hsa034200.80333771
79Mismatch repair_Homo sapiens_hsa034300.80114636
80Retinol metabolism_Homo sapiens_hsa008300.79123750
81Phagosome_Homo sapiens_hsa041450.77184276
82cAMP signaling pathway_Homo sapiens_hsa040240.76970874
83Estrogen signaling pathway_Homo sapiens_hsa049150.76281244
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73845360
85Type I diabetes mellitus_Homo sapiens_hsa049400.73744044
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73478750
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72610151
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72259331
89Arginine and proline metabolism_Homo sapiens_hsa003300.69925353
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69176924
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.67956767
92Vitamin B6 metabolism_Homo sapiens_hsa007500.67108292
93One carbon pool by folate_Homo sapiens_hsa006700.66289646
94Axon guidance_Homo sapiens_hsa043600.65889931
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65276875
96Circadian rhythm_Homo sapiens_hsa047100.64561901
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.64045096
98Purine metabolism_Homo sapiens_hsa002300.63159172
99RNA transport_Homo sapiens_hsa030130.62723759
100Fat digestion and absorption_Homo sapiens_hsa049750.61970802
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61665088
102Melanogenesis_Homo sapiens_hsa049160.60620105
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59931375
104Glucagon signaling pathway_Homo sapiens_hsa049220.58052964
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55648498
106Vitamin digestion and absorption_Homo sapiens_hsa049770.55490500
107Mineral absorption_Homo sapiens_hsa049780.54062390
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51080865
109Glutathione metabolism_Homo sapiens_hsa004800.50901319
110Thyroid hormone synthesis_Homo sapiens_hsa049180.50803928
111ErbB signaling pathway_Homo sapiens_hsa040120.49401178
112Pancreatic secretion_Homo sapiens_hsa049720.46147407
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45979085
114Alcoholism_Homo sapiens_hsa050340.45188622
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44188041
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43507402
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43059056
118Pyrimidine metabolism_Homo sapiens_hsa002400.42440093
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41129067
120Fatty acid biosynthesis_Homo sapiens_hsa000610.40213669
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39375994
122Protein export_Homo sapiens_hsa030600.39190957
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38600403
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37985767
125Dorso-ventral axis formation_Homo sapiens_hsa043200.37336790
126Prion diseases_Homo sapiens_hsa050200.36589150
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36500846
128Glioma_Homo sapiens_hsa052140.36340687
129MAPK signaling pathway_Homo sapiens_hsa040100.35781516
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34684031
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34249221
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33095857
133Type II diabetes mellitus_Homo sapiens_hsa049300.32188139
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31543025
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.31493937
136African trypanosomiasis_Homo sapiens_hsa051430.31357761
137Fatty acid elongation_Homo sapiens_hsa000620.29852492
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29069127
139Ether lipid metabolism_Homo sapiens_hsa005650.26779749
140Inositol phosphate metabolism_Homo sapiens_hsa005620.26565458
141Ras signaling pathway_Homo sapiens_hsa040140.25786540
142Butanoate metabolism_Homo sapiens_hsa006500.24543662
143Regulation of autophagy_Homo sapiens_hsa041400.23890686
144Dilated cardiomyopathy_Homo sapiens_hsa054140.23520159
145Choline metabolism in cancer_Homo sapiens_hsa052310.21932263
146Metabolic pathways_Homo sapiens_hsa011000.21335580
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18291974
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.18085501
149Ovarian steroidogenesis_Homo sapiens_hsa049130.16853672
150RNA polymerase_Homo sapiens_hsa030200.15012995
151Renal cell carcinoma_Homo sapiens_hsa052110.12476853
152Sulfur metabolism_Homo sapiens_hsa009200.08819617
153Cysteine and methionine metabolism_Homo sapiens_hsa002700.08810693

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