RWDD2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1production of molecular mediator involved in inflammatory response (GO:0002532)4.71731025
2cellular ketone body metabolic process (GO:0046950)4.57977078
3ketone body metabolic process (GO:1902224)4.53558873
4ribosomal small subunit assembly (GO:0000028)4.34733477
5regulation of hexokinase activity (GO:1903299)4.15004149
6regulation of glucokinase activity (GO:0033131)4.15004149
7respiratory chain complex IV assembly (GO:0008535)4.03156342
8protein complex biogenesis (GO:0070271)4.00487615
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96398759
10purine nucleobase biosynthetic process (GO:0009113)3.96304076
11signal peptide processing (GO:0006465)3.92613353
12cytochrome complex assembly (GO:0017004)3.89481492
13DNA deamination (GO:0045006)3.79665632
14cellular response to interferon-beta (GO:0035458)3.75826235
15nucleobase biosynthetic process (GO:0046112)3.74578671
16protein K6-linked ubiquitination (GO:0085020)3.69400537
17mitochondrial respiratory chain complex assembly (GO:0033108)3.64180911
18cullin deneddylation (GO:0010388)3.62234684
19attachment of spindle microtubules to kinetochore (GO:0008608)3.61584305
20branched-chain amino acid catabolic process (GO:0009083)3.54952065
21electron transport chain (GO:0022900)3.49646961
22respiratory electron transport chain (GO:0022904)3.48160494
23protein deneddylation (GO:0000338)3.46404746
24piRNA metabolic process (GO:0034587)3.43328083
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.41230953
26serine family amino acid biosynthetic process (GO:0009070)3.38670528
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37868502
28dopamine transport (GO:0015872)3.36720124
29CENP-A containing nucleosome assembly (GO:0034080)3.35307173
30DNA strand elongation (GO:0022616)3.32570665
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29091780
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.29091780
33NADH dehydrogenase complex assembly (GO:0010257)3.29091780
34proteasome assembly (GO:0043248)3.27707599
35water-soluble vitamin biosynthetic process (GO:0042364)3.26640203
36lactate metabolic process (GO:0006089)3.25834861
37mitotic metaphase plate congression (GO:0007080)3.24687457
38positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.22379956
39pseudouridine synthesis (GO:0001522)3.22158415
40DNA strand elongation involved in DNA replication (GO:0006271)3.21045039
41inositol phosphate catabolic process (GO:0071545)3.20731253
42response to interferon-beta (GO:0035456)3.15202677
43amino acid salvage (GO:0043102)3.14483040
44L-methionine salvage (GO:0071267)3.14483040
45L-methionine biosynthetic process (GO:0071265)3.14483040
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11630796
47phosphorylated carbohydrate dephosphorylation (GO:0046838)3.08511500
48inositol phosphate dephosphorylation (GO:0046855)3.08511500
49termination of RNA polymerase III transcription (GO:0006386)3.08351229
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.08351229
51oxidative phosphorylation (GO:0006119)3.08259007
52positive regulation of protein autophosphorylation (GO:0031954)3.07206454
53regulation of cellular amino acid metabolic process (GO:0006521)3.07111439
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06674523
55negative regulation of ligase activity (GO:0051352)3.06674523
56DNA unwinding involved in DNA replication (GO:0006268)3.05850534
57regulation of type B pancreatic cell apoptotic process (GO:2000674)3.05623116
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05619167
59cysteine metabolic process (GO:0006534)3.05535973
60pteridine-containing compound biosynthetic process (GO:0042559)3.04489908
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.03920342
62negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03107006
63negative regulation of T-helper cell differentiation (GO:0045623)3.03107006
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02064968
65telomere maintenance via semi-conservative replication (GO:0032201)3.01815050
66cytidine deamination (GO:0009972)3.01236101
67cytidine metabolic process (GO:0046087)3.01236101
68cytidine catabolic process (GO:0006216)3.01236101
69ribosome assembly (GO:0042255)3.01090126
70chromatin remodeling at centromere (GO:0031055)3.00723607
71AMP metabolic process (GO:0046033)3.00636854
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99560958
73L-phenylalanine metabolic process (GO:0006558)2.99406313
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.99406313
75regulation of mitochondrial translation (GO:0070129)2.98839593
76L-phenylalanine catabolic process (GO:0006559)2.97728391
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97728391
78urate metabolic process (GO:0046415)2.97154925
79maturation of 5.8S rRNA (GO:0000460)2.96536461
80regulation of cellular respiration (GO:0043457)2.95750098
81telomere maintenance via recombination (GO:0000722)2.95135787
82glycine metabolic process (GO:0006544)2.94773255
83ribosomal small subunit biogenesis (GO:0042274)2.93800171
84L-serine metabolic process (GO:0006563)2.93112021
85mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.93079428
86polyol catabolic process (GO:0046174)2.92701804
87transcription from mitochondrial promoter (GO:0006390)2.91710797
88rRNA methylation (GO:0031167)2.89805287
89nucleotide transmembrane transport (GO:1901679)2.89608569
90purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.88805735
91rRNA modification (GO:0000154)2.88589784
92formation of translation preinitiation complex (GO:0001731)2.87203353
93xenobiotic catabolic process (GO:0042178)2.86473084
94cholesterol biosynthetic process (GO:0006695)2.84800371
95antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84799294
96definitive hemopoiesis (GO:0060216)2.84663418
97regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.83893937
98viral transcription (GO:0019083)2.83839944
99branched-chain amino acid metabolic process (GO:0009081)2.80864774
100DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78989604
101platelet dense granule organization (GO:0060155)2.78879604
102synapsis (GO:0007129)2.76922785
103translational termination (GO:0006415)2.76870595
104RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76374725
105tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76374725
106adenosine metabolic process (GO:0046085)2.75178054
107aldehyde catabolic process (GO:0046185)2.74508253
108mannosylation (GO:0097502)2.73480071
109keratinocyte development (GO:0003334)2.72842454
110signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72189588
111intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72189588
112folic acid metabolic process (GO:0046655)2.69733006
113serine family amino acid metabolic process (GO:0009069)2.69364248
114glucose 6-phosphate metabolic process (GO:0051156)2.69106440
115positive regulation of actin filament depolymerization (GO:0030836)2.67407986
116signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.66817186
117signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66817186
118signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.66817186
119DNA replication initiation (GO:0006270)2.66146323
120RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65296253
121maturation of SSU-rRNA (GO:0030490)2.64734387
122peptidyl-histidine modification (GO:0018202)2.64585352
123regulation of meiosis I (GO:0060631)2.63817665
124ATP synthesis coupled proton transport (GO:0015986)2.63603979
125energy coupled proton transport, down electrochemical gradient (GO:0015985)2.63603979
126antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.63240443
127antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.63240443
128fat-soluble vitamin biosynthetic process (GO:0042362)2.62920972
129glyoxylate metabolic process (GO:0046487)2.62889714
130phosphatidylinositol acyl-chain remodeling (GO:0036149)2.62778670
131methionine biosynthetic process (GO:0009086)2.61795325
132negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.60678009
133ribonucleoprotein complex biogenesis (GO:0022613)2.60347887
134nucleoside salvage (GO:0043174)2.60154564
135triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.59248514
136mitochondrial RNA metabolic process (GO:0000959)2.58239179
137positive regulation of glycolytic process (GO:0045821)2.57888966
138aromatic amino acid family catabolic process (GO:0009074)2.57868564
139deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56497158
140inner mitochondrial membrane organization (GO:0007007)2.56164471
141signal transduction involved in DNA integrity checkpoint (GO:0072401)2.56001885
142signal transduction involved in DNA damage checkpoint (GO:0072422)2.56001885
143S-adenosylmethionine metabolic process (GO:0046500)2.55844959
144negative regulation of execution phase of apoptosis (GO:1900118)2.54836770
145T cell apoptotic process (GO:0070231)2.54291421
146proton transport (GO:0015992)2.53461749
147hydrogen ion transmembrane transport (GO:1902600)2.53055363
148ribosome biogenesis (GO:0042254)2.52634937
149regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.52165533
150translational elongation (GO:0006414)2.51483450
151positive regulation of ligase activity (GO:0051351)2.51420309
152regulation of metalloenzyme activity (GO:0048552)2.51164378
153signal transduction involved in cell cycle checkpoint (GO:0072395)2.50460199
154positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.50203981
155purine-containing compound salvage (GO:0043101)2.49819184
156mitotic recombination (GO:0006312)2.49373874
157regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.48637342
158hydrogen transport (GO:0006818)2.47746981
159sterol biosynthetic process (GO:0016126)2.47746618
160pyrimidine ribonucleoside catabolic process (GO:0046133)2.47412262
161positive regulation of chromosome segregation (GO:0051984)2.46962401
162DNA replication-independent nucleosome assembly (GO:0006336)2.46736800
163DNA replication-independent nucleosome organization (GO:0034724)2.46736800
164antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.46657837
165nucleoside diphosphate biosynthetic process (GO:0009133)2.46384221
166SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.44673967
167G1/S transition of mitotic cell cycle (GO:0000082)2.43581197
168cell cycle G1/S phase transition (GO:0044843)2.43581197
169ribosomal large subunit biogenesis (GO:0042273)2.43453768
170aerobic respiration (GO:0009060)2.42829972
171dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.42397810
172sulfur amino acid biosynthetic process (GO:0000097)2.41995955
173cotranslational protein targeting to membrane (GO:0006613)2.41896849
174homocysteine metabolic process (GO:0050667)2.41722416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.76855473
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.54771707
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.07812881
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.64717397
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.58818775
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.55363271
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54513514
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.05731516
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.05654303
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79021830
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55564163
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.55425635
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55254694
14ZNF274_21170338_ChIP-Seq_K562_Hela2.52600753
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50150093
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44226139
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.43080558
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42431052
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.29088922
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27225429
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15470814
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14209141
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12564255
24* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08714821
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06614505
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05183964
27VDR_22108803_ChIP-Seq_LS180_Human2.00321431
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97643693
29AR_21909140_ChIP-Seq_LNCAP_Human1.94373889
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.91204893
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89049559
32VDR_23849224_ChIP-Seq_CD4+_Human1.88961604
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.88353498
34FOXP3_21729870_ChIP-Seq_TREG_Human1.88229413
35FUS_26573619_Chip-Seq_HEK293_Human1.87369233
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83961748
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.83152139
38DCP1A_22483619_ChIP-Seq_HELA_Human1.82860400
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81844575
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79143644
41* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78484787
42GBX2_23144817_ChIP-Seq_PC3_Human1.78234249
43ER_23166858_ChIP-Seq_MCF-7_Human1.76367174
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74429085
45ELK1_19687146_ChIP-ChIP_HELA_Human1.74146301
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.73669685
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71974346
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71089776
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70729532
50* GABP_19822575_ChIP-Seq_HepG2_Human1.68197151
51* XRN2_22483619_ChIP-Seq_HELA_Human1.67784198
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.67696923
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67638136
54EWS_26573619_Chip-Seq_HEK293_Human1.67139689
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66772295
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66107663
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.65504704
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64295489
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63735041
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62700614
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59628031
62IGF1R_20145208_ChIP-Seq_DFB_Human1.58333056
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54880174
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.54426858
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53445580
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52229711
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51018364
68HTT_18923047_ChIP-ChIP_STHdh_Human1.50977863
69P300_19829295_ChIP-Seq_ESCs_Human1.48323088
70MYC_22102868_ChIP-Seq_BL_Human1.47461509
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46662772
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.44641827
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43500396
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42148264
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.41593719
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41580210
77SCL_19346495_ChIP-Seq_HPC-7_Human1.41351123
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.39949539
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39327689
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36981294
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36857435
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36655340
83SPI1_23547873_ChIP-Seq_NB4_Human1.36584717
84NANOG_19829295_ChIP-Seq_ESCs_Human1.36541895
85SOX2_19829295_ChIP-Seq_ESCs_Human1.36541895
86GATA1_22025678_ChIP-Seq_K562_Human1.36527623
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36297902
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.35123967
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34691753
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.34535057
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33027383
92CDX2_22108803_ChIP-Seq_LS180_Human1.32620396
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.32507242
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.30849242
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30849242
96TP53_22573176_ChIP-Seq_HFKS_Human1.30595186
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28524824
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27646836
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26900183
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.25901185
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25739966
102YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25384513
103AR_20517297_ChIP-Seq_VCAP_Human1.25317003
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.23637376
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20737820
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20506047
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.19697788
108MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19222827
109MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18054829
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17885211
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16929515
112CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15033022
113CBP_20019798_ChIP-Seq_JUKART_Human1.14097113
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14097113
115STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10973813
116AR_25329375_ChIP-Seq_VCAP_Human1.10884199
117CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09509665
118LXR_22158963_ChIP-Seq_LIVER_Mouse1.09354710
119NOTCH1_21737748_ChIP-Seq_TLL_Human1.09347161
120MYC_18940864_ChIP-ChIP_HL60_Human1.09090163
121STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08662642
122TTF2_22483619_ChIP-Seq_HELA_Human1.07876375
123GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07307077
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06739279
125* ELK1_22589737_ChIP-Seq_MCF10A_Human1.06557842
126CJUN_26792858_Chip-Seq_BT549_Human1.06551015
127GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06311976
128HOXB7_26014856_ChIP-Seq_BT474_Human1.05326006
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05278196
130RUNX1_22412390_ChIP-Seq_EML_Mouse1.05241416
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05237944
132SMAD4_21799915_ChIP-Seq_A2780_Human1.05058852
133FOXM1_23109430_ChIP-Seq_U2OS_Human1.04985087
134PHF8_20622853_ChIP-Seq_HELA_Human1.04678615
135KDM5A_27292631_Chip-Seq_BREAST_Human1.03877753
136CIITA_25753668_ChIP-Seq_RAJI_Human1.03197095
137FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02960181
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02952016
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02681191
140BCAT_22108803_ChIP-Seq_LS180_Human1.02650804
141STAT3_18555785_Chip-Seq_ESCs_Mouse1.02298553
142PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02298138
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02212345
144SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01939202
145TFEB_21752829_ChIP-Seq_HELA_Human1.01856013
146KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00808542
147SALL4_22934838_ChIP-ChIP_CD34+_Human0.99772584
148TCF4_22108803_ChIP-Seq_LS180_Human0.98955590
149P53_22387025_ChIP-Seq_ESCs_Mouse0.98215262
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.98158989
151GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98137827
152SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97840378
153BRD4_25478319_ChIP-Seq_HGPS_Human0.96489791
154CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96006974
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95778392
156STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95402792
157STAT3_23295773_ChIP-Seq_U87_Human0.95387599
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.95339636
159MYB_26560356_Chip-Seq_TH1_Human0.94905525
160RBPJ_21746931_ChIP-Seq_IB4_Human0.94769030
161ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93864589
162FOXH1_21741376_ChIP-Seq_EPCs_Human0.93696354
163NCOR_22424771_ChIP-Seq_293T_Human0.93608236
164CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92583390
165CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92331023
166LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91536125
167BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90403071
168MYB_26560356_Chip-Seq_TH2_Human0.90148024
169PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89212433
170KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88269292
171NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88162224
172NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87651283
173IRF1_19129219_ChIP-ChIP_H3396_Human0.86656080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.79080169
2MP0000372_irregular_coat_pigmentation4.95306783
3MP0002139_abnormal_hepatobiliary_system4.22905680
4MP0003806_abnormal_nucleotide_metabolis3.94814769
5MP0002837_dystrophic_cardiac_calcinosis3.76545808
6MP0003950_abnormal_plasma_membrane3.40221872
7MP0003183_abnormal_peptide_metabolism3.39349816
8MP0009780_abnormal_chondrocyte_physiolo3.28532383
9MP0005085_abnormal_gallbladder_physiolo2.95138036
10MP0009697_abnormal_copulation2.53860914
11MP0005365_abnormal_bile_salt2.53839297
12MP0008875_abnormal_xenobiotic_pharmacok2.53519385
13MP0004957_abnormal_blastocyst_morpholog2.46723451
14MP0003646_muscle_fatigue2.38423873
15MP0000013_abnormal_adipose_tissue2.34200560
16MP0003693_abnormal_embryo_hatching2.31596197
17MP0001666_abnormal_nutrient_absorption2.26494212
18MP0004145_abnormal_muscle_electrophysio2.25557081
19MP0000749_muscle_degeneration2.25470821
20MP0005408_hypopigmentation2.25004910
21MP0003656_abnormal_erythrocyte_physiolo2.21093611
22MP0005464_abnormal_platelet_physiology2.20282977
23MP0004147_increased_porphyrin_level2.18419255
24MP0005379_endocrine/exocrine_gland_phen2.18187688
25MP0010386_abnormal_urinary_bladder1.97144725
26MP0006036_abnormal_mitochondrial_physio1.91197021
27MP0008058_abnormal_DNA_repair1.90535872
28MP0005645_abnormal_hypothalamus_physiol1.88175895
29MP0005075_abnormal_melanosome_morpholog1.87350253
30MP0001835_abnormal_antigen_presentation1.86220919
31MP0002163_abnormal_gland_morphology1.85850828
32MP0005332_abnormal_amino_acid1.83789283
33MP0002396_abnormal_hematopoietic_system1.78055318
34MP0002138_abnormal_hepatobiliary_system1.76660014
35MP0009840_abnormal_foam_cell1.74008002
36MP0002102_abnormal_ear_morphology1.72509699
37MP0006054_spinal_hemorrhage1.69826304
38MP0005171_absent_coat_pigmentation1.68656691
39MP0009333_abnormal_splenocyte_physiolog1.63766490
40MP0003786_premature_aging1.62773815
41MP0003077_abnormal_cell_cycle1.62664355
42MP0003718_maternal_effect1.61240302
43MP0005319_abnormal_enzyme/_coenzyme1.60623205
44MP0002398_abnormal_bone_marrow1.60361450
45MP0005584_abnormal_enzyme/coenzyme_acti1.59597380
46MP0001529_abnormal_vocalization1.57903479
47MP0000689_abnormal_spleen_morphology1.57799816
48MP0005671_abnormal_response_to1.57759436
49MP0000015_abnormal_ear_pigmentation1.56335473
50MP0006072_abnormal_retinal_apoptosis1.56231391
51MP0010094_abnormal_chromosome_stability1.56017879
52MP0002160_abnormal_reproductive_system1.55939288
53MP0000427_abnormal_hair_cycle1.54578394
54MP0006082_CNS_inflammation1.53743406
55MP0004808_abnormal_hematopoietic_stem1.52162272
56MP0005451_abnormal_body_composition1.51953306
57MP0008877_abnormal_DNA_methylation1.49265946
58MP0001800_abnormal_humoral_immune1.49243335
59MP0005000_abnormal_immune_tolerance1.48099213
60MP0002148_abnormal_hypersensitivity_rea1.46869357
61MP0005025_abnormal_response_to1.46846790
62MP0005551_abnormal_eye_electrophysiolog1.44941347
63MP0003186_abnormal_redox_activity1.43497144
64MP0005174_abnormal_tail_pigmentation1.43097268
65MP0006035_abnormal_mitochondrial_morpho1.42405706
66MP0002938_white_spotting1.40176507
67MP0001348_abnormal_lacrimal_gland1.40163710
68MP0002722_abnormal_immune_system1.39718827
69MP0008007_abnormal_cellular_replicative1.37839274
70MP0009379_abnormal_foot_pigmentation1.37700317
71MP0008872_abnormal_physiological_respon1.37688514
72MP0001905_abnormal_dopamine_level1.37304513
73MP0005389_reproductive_system_phenotype1.35899463
74MP0000716_abnormal_immune_system1.35431768
75MP0001661_extended_life_span1.34507616
76MP0008469_abnormal_protein_level1.33131935
77MP0002429_abnormal_blood_cell1.32568442
78MP0010329_abnormal_lipoprotein_level1.32234720
79MP0000490_abnormal_crypts_of1.31615283
80MP0002452_abnormal_antigen_presenting1.29477798
81MP0001853_heart_inflammation1.29394676
82MP0002723_abnormal_immune_serum1.27742360
83MP0004036_abnormal_muscle_relaxation1.27352629
84MP0005253_abnormal_eye_physiology1.26736689
85MP0002420_abnormal_adaptive_immunity1.26594731
86MP0009785_altered_susceptibility_to1.26172380
87MP0002693_abnormal_pancreas_physiology1.25923176
88MP0001819_abnormal_immune_cell1.25274988
89MP0003763_abnormal_thymus_physiology1.23964605
90MP0000538_abnormal_urinary_bladder1.22643632
91MP0001944_abnormal_pancreas_morphology1.22257604
92MP0002090_abnormal_vision1.19824678
93MP0010234_abnormal_vibrissa_follicle1.19377264
94MP0001764_abnormal_homeostasis1.19282340
95MP0005367_renal/urinary_system_phenotyp1.19090550
96MP0000516_abnormal_urinary_system1.19090550
97MP0000685_abnormal_immune_system1.17705778
98MP0003011_delayed_dark_adaptation1.17531819
99MP0005310_abnormal_salivary_gland1.17409058
100MP0000609_abnormal_liver_physiology1.15589201
101MP0000465_gastrointestinal_hemorrhage1.15572074
102MP0003191_abnormal_cellular_cholesterol1.14611616
103MP0010155_abnormal_intestine_physiology1.13346821
104MP0004215_abnormal_myocardial_fiber1.13112703
105MP0003866_abnormal_defecation1.12620267
106MP0002928_abnormal_bile_duct1.12604339
107MP0004510_myositis1.12515991
108MP0005058_abnormal_lysosome_morphology1.11242131
109MP0000598_abnormal_liver_morphology1.10069377
110MP0004084_abnormal_cardiac_muscle1.10059497
111MP0003436_decreased_susceptibility_to1.09652019
112MP0008057_abnormal_DNA_replication1.08534211
113MP0009765_abnormal_xenobiotic_induced1.08392787
114MP0002166_altered_tumor_susceptibility1.08273282
115MP0002419_abnormal_innate_immunity1.07054268
116MP0009643_abnormal_urine_homeostasis1.06356669
117MP0004043_abnormal_pH_regulation1.05713614
118MP0005646_abnormal_pituitary_gland1.05451710
119MP0002909_abnormal_adrenal_gland1.05208105
120MP0005387_immune_system_phenotype1.04557864
121MP0001790_abnormal_immune_system1.04557864
122MP0009764_decreased_sensitivity_to1.03717424
123MP0002269_muscular_atrophy1.03145892
124MP0005266_abnormal_metabolism1.02571434
125MP0001845_abnormal_inflammatory_respons1.02010371
126MP0001873_stomach_inflammation0.99096197
127MP0003221_abnormal_cardiomyocyte_apopto0.98731145
128MP0000703_abnormal_thymus_morphology0.98519682
129MP0003111_abnormal_nucleus_morphology0.97232324
130MP0002132_abnormal_respiratory_system0.97209751
131MP0002234_abnormal_pharynx_morphology0.97108772
132MP0003195_calcinosis0.97036602
133MP0003252_abnormal_bile_duct0.97017606
134MP0000613_abnormal_salivary_gland0.96839932
135MP0000003_abnormal_adipose_tissue0.96666194
136MP0002876_abnormal_thyroid_physiology0.96294061
137MP0008873_increased_physiological_sensi0.95881532
138MP0008775_abnormal_heart_ventricle0.95036672
139MP0005084_abnormal_gallbladder_morpholo0.94781484
140MP0005220_abnormal_exocrine_pancreas0.94409222
141MP0005636_abnormal_mineral_homeostasis0.93382581
142MP0005330_cardiomyopathy0.93115051
143MP0009046_muscle_twitch0.93025151
144MP0002254_reproductive_system_inflammat0.91817828
145MP0001542_abnormal_bone_strength0.91249453
146MP0004142_abnormal_muscle_tone0.91014482
147MP0000358_abnormal_cell_content/0.89549482
148MP0005410_abnormal_fertilization0.87423995
149MP0004019_abnormal_vitamin_homeostasis0.86542616
150MP0003315_abnormal_perineum_morphology0.85386021
151MP0002019_abnormal_tumor_incidence0.84254070
152MP0001756_abnormal_urination0.82917250
153MP0002136_abnormal_kidney_physiology0.82856107
154MP0001986_abnormal_taste_sensitivity0.81426304
155MP0003045_fibrosis0.81365144
156MP0005395_other_phenotype0.80153065
157MP0002006_tumorigenesis0.79710297
158MP0002295_abnormal_pulmonary_circulatio0.79600565
159MP0002332_abnormal_exercise_endurance0.79469453
160MP0002736_abnormal_nociception_after0.79211806
161MP0000371_diluted_coat_color0.78682196
162MP0002405_respiratory_system_inflammati0.78034826
163MP0008932_abnormal_embryonic_tissue0.77104017
164MP0004947_skin_inflammation0.76986869
165MP0002078_abnormal_glucose_homeostasis0.76950579
166MP0002095_abnormal_skin_pigmentation0.76081496
167MP0005083_abnormal_biliary_tract0.74907794
168MP0001730_embryonic_growth_arrest0.74779601
169MP0005620_abnormal_muscle_contractility0.74748698
170MP0002638_abnormal_pupillary_reflex0.74185736
171MP0001919_abnormal_reproductive_system0.71515098
172MP0010678_abnormal_skin_adnexa0.68823274
173MP0002106_abnormal_muscle_physiology0.67044571

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)5.06003393
2Nemaline bodies (HP:0003798)3.98024656
3Progressive macrocephaly (HP:0004481)3.93192235
43-Methylglutaconic aciduria (HP:0003535)3.79394023
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.65517658
6Muscle fiber inclusion bodies (HP:0100299)3.49724781
7Ketoacidosis (HP:0001993)3.49192970
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.48837685
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.48807684
10Petechiae (HP:0000967)3.38350772
11Abnormality of T cell physiology (HP:0011840)3.33210785
12Increased serum pyruvate (HP:0003542)3.29458801
13Abnormality of glycolysis (HP:0004366)3.29458801
14Increased hepatocellular lipid droplets (HP:0006565)3.23251192
15Thrombocytosis (HP:0001894)3.17717092
16Lipid accumulation in hepatocytes (HP:0006561)3.17655753
17Chronic otitis media (HP:0000389)3.12078596
18Abnormality of aspartate family amino acid metabolism (HP:0010899)3.05123917
19Hepatocellular necrosis (HP:0001404)3.04092894
20Aplasia/Hypoplasia of the fovea (HP:0008060)3.03944568
21Hypoplasia of the fovea (HP:0007750)3.03944568
22Hepatic necrosis (HP:0002605)3.02982233
23Hypothermia (HP:0002045)3.02867276
24Hypoglycemic coma (HP:0001325)3.01560196
25Large for gestational age (HP:0001520)3.00034908
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96820440
27Autoimmune thrombocytopenia (HP:0001973)2.95632389
28Abnormality of methionine metabolism (HP:0010901)2.93371766
29Elevated erythrocyte sedimentation rate (HP:0003565)2.93323904
30Purpura (HP:0000979)2.90185053
31Type 2 muscle fiber atrophy (HP:0003554)2.85146389
32Recurrent viral infections (HP:0004429)2.85141283
33Proximal tubulopathy (HP:0000114)2.81924787
34Hyperammonemia (HP:0001987)2.80417942
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.78931920
36Megaloblastic anemia (HP:0001889)2.76697602
37Abnormality of monocarboxylic acid metabolism (HP:0010996)2.74256149
38Glycosuria (HP:0003076)2.71480761
39Abnormality of urine glucose concentration (HP:0011016)2.71480761
40Albinism (HP:0001022)2.67849338
41Hyperinsulinemic hypoglycemia (HP:0000825)2.65966122
42Acute encephalopathy (HP:0006846)2.64546325
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64208254
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64208254
45Mitochondrial inheritance (HP:0001427)2.63175185
46Pancreatic cysts (HP:0001737)2.63097707
47Abnormality of the renal cortex (HP:0011035)2.63044750
48Abnormality of sulfur amino acid metabolism (HP:0004339)2.61647196
49Intrahepatic cholestasis (HP:0001406)2.61575456
50Conjunctival hamartoma (HP:0100780)2.60798487
51Abnormality of the fovea (HP:0000493)2.60427194
52Delayed gross motor development (HP:0002194)2.59427287
53Exertional dyspnea (HP:0002875)2.59342940
54Increased CSF lactate (HP:0002490)2.56063724
55Abnormality of pyrimidine metabolism (HP:0004353)2.55160374
56Increased intramyocellular lipid droplets (HP:0012240)2.55140603
57Congenital stationary night blindness (HP:0007642)2.53716347
58Renal Fanconi syndrome (HP:0001994)2.52991417
59Generalized aminoaciduria (HP:0002909)2.52112097
60Reduced antithrombin III activity (HP:0001976)2.49702676
61Impaired platelet aggregation (HP:0003540)2.48700384
62Abnormal platelet function (HP:0011869)2.48700384
63Type I transferrin isoform profile (HP:0003642)2.45027901
64Respiratory failure (HP:0002878)2.45006681
65Cholecystitis (HP:0001082)2.44272408
66Abnormal gallbladder physiology (HP:0012438)2.44272408
67Renal cortical cysts (HP:0000803)2.43671709
68Acute necrotizing encephalopathy (HP:0006965)2.42945309
69Increased serum lactate (HP:0002151)2.42418894
70Hyperglycemia (HP:0003074)2.41109442
71Abnormality of placental membranes (HP:0011409)2.38198412
72Amniotic constriction ring (HP:0009775)2.38198412
73Deep venous thrombosis (HP:0002625)2.37745493
74Lactic acidosis (HP:0003128)2.35609271
75Calf muscle hypertrophy (HP:0008981)2.35318993
76Cutaneous melanoma (HP:0012056)2.34682949
77Xanthomatosis (HP:0000991)2.34662717
78Increased muscle lipid content (HP:0009058)2.33169706
79Gingival bleeding (HP:0000225)2.32851890
80Abnormality of T cells (HP:0002843)2.32815202
81Ketosis (HP:0001946)2.32404211
82Hypokinesia (HP:0002375)2.32217995
83Cerebral edema (HP:0002181)2.31776714
84Molar tooth sign on MRI (HP:0002419)2.30963021
85Abnormality of midbrain morphology (HP:0002418)2.30963021
86Methylmalonic acidemia (HP:0002912)2.30781074
87Muscle hypertrophy of the lower extremities (HP:0008968)2.29405588
88Hypolipoproteinemia (HP:0010981)2.29321380
89Abnormal mitochondria in muscle tissue (HP:0008316)2.28865610
90Abnormal platelet volume (HP:0011876)2.28594315
91Macrocytic anemia (HP:0001972)2.28140298
92Conjugated hyperbilirubinemia (HP:0002908)2.27479527
93Popliteal pterygium (HP:0009756)2.24811578
94Hamartoma of the eye (HP:0010568)2.24763774
95Hyperbilirubinemia (HP:0002904)2.24513563
96IgM deficiency (HP:0002850)2.23964836
97Abnormality of serum amino acid levels (HP:0003112)2.23245386
98Prolonged partial thromboplastin time (HP:0003645)2.21852653
99Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21532188
100Tongue fasciculations (HP:0001308)2.19874751
101Abnormality of nucleobase metabolism (HP:0010932)2.19721724
102Joint hemorrhage (HP:0005261)2.19000036
103Birth length less than 3rd percentile (HP:0003561)2.17447831
104Fat malabsorption (HP:0002630)2.16483461
105Increased mean platelet volume (HP:0011877)2.15930671
106Muscle fiber atrophy (HP:0100295)2.15793973
107Abnormality of T cell number (HP:0011839)2.14663937
108Hyperphosphaturia (HP:0003109)2.13752509
109Severe visual impairment (HP:0001141)2.12968189
110Recurrent cutaneous fungal infections (HP:0011370)2.12804716
111Chronic mucocutaneous candidiasis (HP:0002728)2.12804716
112Abnormal protein N-linked glycosylation (HP:0012347)2.12606598
113Abnormal protein glycosylation (HP:0012346)2.12606598
114Abnormal glycosylation (HP:0012345)2.12606598
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12606598
116Lethargy (HP:0001254)2.12260066
117Exercise intolerance (HP:0003546)2.12184075
118Reticulocytopenia (HP:0001896)2.12118442
119Recurrent skin infections (HP:0001581)2.10393033
120Optic disc pallor (HP:0000543)2.10311417
121Cerebral hypomyelination (HP:0006808)2.09708454
122IgG deficiency (HP:0004315)2.08003367
123Pancreatic fibrosis (HP:0100732)2.07367916
124Hyperglycinuria (HP:0003108)2.06278193
125Prolonged bleeding time (HP:0003010)2.06168607
126Respiratory difficulties (HP:0002880)2.06166620
127Abnormality of serine family amino acid metabolism (HP:0010894)2.05089311
128Abnormality of glycine metabolism (HP:0010895)2.05089311
129Diminished movement (HP:0002374)2.04449516
130Methylmalonic aciduria (HP:0012120)2.03455827
131Hyperglycinemia (HP:0002154)2.02101650
132Abnormality of purine metabolism (HP:0004352)2.02002399
133Pustule (HP:0200039)2.01943794
134Abnormal number of erythroid precursors (HP:0012131)2.01276484
135Nephronophthisis (HP:0000090)2.00495727
136Recurrent fungal infections (HP:0002841)2.00035579
137Weak cry (HP:0001612)1.99417975
138Neck muscle weakness (HP:0000467)1.98884069
139Abnormality of cells of the erythroid lineage (HP:0012130)1.98668683
140Abnormality of fatty-acid metabolism (HP:0004359)1.98651211
141Palpitations (HP:0001962)1.98497372
142CNS demyelination (HP:0007305)1.97705506
143Aplasia/hypoplasia of the uterus (HP:0008684)1.97186777
144Ileus (HP:0002595)1.96790163
145Hyperlipoproteinemia (HP:0010980)1.96689476
146Menorrhagia (HP:0000132)1.95652674
147Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95384327
148Aplasia/Hypoplasia of the macula (HP:0008059)1.93554239
149Neoplasm of the adrenal gland (HP:0100631)1.91819477
150Spastic paraparesis (HP:0002313)1.90973407
151Insulin-resistant diabetes mellitus (HP:0000831)1.90848151
152Type II lissencephaly (HP:0007260)1.90396064
153Delayed epiphyseal ossification (HP:0002663)1.89840293
154T lymphocytopenia (HP:0005403)1.89003442
155True hermaphroditism (HP:0010459)1.87661703
156Bone cyst (HP:0012062)1.87287918
157Aplastic anemia (HP:0001915)1.87217179
158Abnormality of the heme biosynthetic pathway (HP:0010472)1.86562455
159Abnormality of vitamin B metabolism (HP:0004340)1.84173191
160Furrowed tongue (HP:0000221)1.83610973
161Abnormality of the neuromuscular junction (HP:0003398)1.82065192
162Fatigable weakness (HP:0003473)1.82065192
163Vascular calcification (HP:0004934)1.81633480
164Hypoalbuminemia (HP:0003073)1.81584592
165Abnormal albumin level (HP:0012116)1.81584592
166Fibular aplasia (HP:0002990)1.80389068
167Abnormality of proline metabolism (HP:0010907)1.79429220
168Hydroxyprolinuria (HP:0003080)1.79429220
169Abnormality of the renal medulla (HP:0100957)1.79302250
170Neuroendocrine neoplasm (HP:0100634)1.78539322
171Aplasia/Hypoplasia affecting the retina (HP:0008061)1.78371136
172Exercise-induced muscle cramps (HP:0003710)1.78080048
173Azoospermia (HP:0000027)1.78054316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.18890581
2BUB14.06311183
3WEE13.25161834
4NME23.10403509
5MUSK2.95022347
6BRSK22.72300448
7MAP4K12.70685145
8STK162.58105836
9MAP3K122.53657936
10NUAK12.43545777
11VRK22.40260789
12PHKG22.40240091
13PHKG12.40240091
14MST42.30329700
15MKNK12.26206849
16BMPR1B2.11162511
17BCKDK2.04707273
18CDC72.04322889
19OBSCN1.98088020
20ACVR1B1.94126370
21TESK21.84313420
22BLK1.83791634
23PIM21.70765269
24STK101.70027959
25ARAF1.69876366
26GRK11.69744747
27PBK1.65046778
28MAPKAPK31.64030530
29PLK21.63333798
30TRIM281.62222075
31GRK61.61315803
32PLK41.57237748
33MYLK1.57086646
34CDK191.56913094
35MAP4K21.55163164
36SIK31.54862530
37KIT1.52308913
38RPS6KB21.45496776
39ERBB31.36895173
40PLK31.36556501
41PINK11.36472030
42PNCK1.36341009
43ZAK1.35445311
44SYK1.34744681
45MAP3K61.33042392
46TXK1.31281167
47BCR1.30868316
48TRPM71.29287973
49BTK1.28402048
50ZAP701.28300321
51FGFR21.26127972
52FLT31.23696904
53EIF2AK31.21159492
54EPHB11.20381878
55STK391.19590518
56PASK1.17897429
57TSSK61.15368024
58MAP3K81.12760390
59LRRK21.10924480
60WNK41.08570687
61TEC1.07079642
62CCNB11.06327452
63TGFBR11.05198889
64OXSR11.02384718
65BRSK11.01315571
66TYK21.00490115
67TLK11.00467434
68PIK3CG1.00137747
69PTK2B0.99380759
70EEF2K0.99225346
71CDK70.98453254
72INSRR0.97754044
73CSNK1G30.97682118
74MAP2K30.93037988
75FER0.91384159
76PLK10.89355354
77PAK30.88294007
78PDK20.88217849
79TAF10.84291448
80EIF2AK20.83529256
81ADRBK10.80442614
82STK30.79616992
83STK240.78527286
84NME10.77646578
85PRKCE0.76851919
86JAK30.76731652
87CSNK1A1L0.76439846
88TNIK0.75874677
89MATK0.74968807
90WNK30.74457509
91RPS6KA40.73099890
92AURKA0.72539723
93BMPR20.72024301
94CSF1R0.71301538
95BRAF0.70939844
96CSNK1G10.70922858
97NEK20.69901369
98VRK10.69870827
99STK38L0.68531240
100PRKCI0.66756017
101ERN10.66380532
102LCK0.63974828
103LYN0.62288134
104TAOK30.61975386
105CASK0.61597919
106MST1R0.61536899
107SRPK10.61058166
108ERBB40.58371705
109CDK80.58244739
110PIM10.57749786
111NEK10.56892817
112AURKB0.56185205
113DAPK10.56075727
114MAP2K60.55439134
115ILK0.55037851
116STK40.52897722
117MAPKAPK50.51355571
118IKBKB0.51139549
119GRK50.50836588
120ATR0.50262460
121FRK0.49804032
122MAPK40.48600266
123FGFR40.48253817
124MKNK20.48230812
125CAMK2D0.47810036
126ADRBK20.47062683
127CSNK2A20.46479358
128MAP3K100.45939286
129MAPK110.45405496
130GRK70.43577397
131ABL20.43496638
132TTK0.42393625
133TBK10.42392058
134CSNK2A10.41942568
135MAP3K110.41650090
136NLK0.41301460
137IKBKE0.40861049
138CDK40.38099044
139ITK0.37723618
140LIMK10.37593630
141MET0.36004683
142PRKCD0.35813033
143RIPK40.35748810
144PRKAA20.34884009
145PKN20.34852770
146CAMKK20.34404320
147CSNK1G20.34334108
148PIK3CA0.33588170
149MOS0.32980000
150SCYL20.31792102
151PAK10.31108671
152ROCK10.30007094
153PRKCG0.29784977
154AKT30.28162128
155IGF1R0.27602961
156AKT20.26860099
157CSNK1A10.26619971

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.56381594
2DNA replication_Homo sapiens_hsa030303.17109203
3Ribosome_Homo sapiens_hsa030102.65182179
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.60494100
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.50413587
6Folate biosynthesis_Homo sapiens_hsa007902.46414653
7Mismatch repair_Homo sapiens_hsa034302.24642193
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.18293157
9Steroid biosynthesis_Homo sapiens_hsa001002.05235060
10RNA polymerase_Homo sapiens_hsa030201.89799781
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88662056
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81277781
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76733564
14Pentose phosphate pathway_Homo sapiens_hsa000301.75665561
15Pyrimidine metabolism_Homo sapiens_hsa002401.75373457
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74642822
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.73353235
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72698949
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71111008
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.69431616
21One carbon pool by folate_Homo sapiens_hsa006701.65500893
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63736097
23Biosynthesis of amino acids_Homo sapiens_hsa012301.58613657
24Peroxisome_Homo sapiens_hsa041461.52457096
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.51023093
26Base excision repair_Homo sapiens_hsa034101.49818127
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47736898
28Carbon metabolism_Homo sapiens_hsa012001.40964879
29Phototransduction_Homo sapiens_hsa047441.39680128
30Propanoate metabolism_Homo sapiens_hsa006401.38053767
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37586671
32Selenocompound metabolism_Homo sapiens_hsa004501.37409327
33Parkinsons disease_Homo sapiens_hsa050121.36279318
34Oxidative phosphorylation_Homo sapiens_hsa001901.35396410
35Fructose and mannose metabolism_Homo sapiens_hsa000511.35160370
36RNA transport_Homo sapiens_hsa030131.34936246
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33533858
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32292065
39Spliceosome_Homo sapiens_hsa030401.30417958
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29310670
41Collecting duct acid secretion_Homo sapiens_hsa049661.26701338
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25339173
43Vitamin B6 metabolism_Homo sapiens_hsa007501.25131773
44Homologous recombination_Homo sapiens_hsa034401.23769497
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21471283
46Fanconi anemia pathway_Homo sapiens_hsa034601.16182882
47Glutathione metabolism_Homo sapiens_hsa004801.16061246
48Histidine metabolism_Homo sapiens_hsa003401.14938965
49Pyruvate metabolism_Homo sapiens_hsa006201.13980839
50RNA degradation_Homo sapiens_hsa030181.13922405
51Cell cycle_Homo sapiens_hsa041101.12283782
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11691285
53Caffeine metabolism_Homo sapiens_hsa002321.10542797
54Tryptophan metabolism_Homo sapiens_hsa003801.08819679
55Fatty acid degradation_Homo sapiens_hsa000711.08479312
56Arginine biosynthesis_Homo sapiens_hsa002201.06439694
57Cardiac muscle contraction_Homo sapiens_hsa042601.05275096
58Circadian rhythm_Homo sapiens_hsa047101.04893619
59Fatty acid elongation_Homo sapiens_hsa000621.04390509
60Ether lipid metabolism_Homo sapiens_hsa005651.01348828
61Nucleotide excision repair_Homo sapiens_hsa034200.99327169
62Sulfur relay system_Homo sapiens_hsa041220.99151328
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96852900
64Fat digestion and absorption_Homo sapiens_hsa049750.93636826
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93401875
66Nitrogen metabolism_Homo sapiens_hsa009100.93356640
67Allograft rejection_Homo sapiens_hsa053300.93203392
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93144580
69Butanoate metabolism_Homo sapiens_hsa006500.88283789
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87650626
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87315793
72Arginine and proline metabolism_Homo sapiens_hsa003300.84837903
73Primary immunodeficiency_Homo sapiens_hsa053400.84342210
74Non-homologous end-joining_Homo sapiens_hsa034500.83095486
75Alzheimers disease_Homo sapiens_hsa050100.82229287
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81222658
77Purine metabolism_Homo sapiens_hsa002300.79848461
78Protein export_Homo sapiens_hsa030600.78561102
79Retinol metabolism_Homo sapiens_hsa008300.77341427
80Complement and coagulation cascades_Homo sapiens_hsa046100.74841067
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74436393
82Huntingtons disease_Homo sapiens_hsa050160.73843255
83Galactose metabolism_Homo sapiens_hsa000520.73176030
84Starch and sucrose metabolism_Homo sapiens_hsa005000.73075739
85Vitamin digestion and absorption_Homo sapiens_hsa049770.72957215
86beta-Alanine metabolism_Homo sapiens_hsa004100.72929597
87Metabolic pathways_Homo sapiens_hsa011000.72458762
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72156100
89Arachidonic acid metabolism_Homo sapiens_hsa005900.69592931
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.68423415
91Fatty acid metabolism_Homo sapiens_hsa012120.68103520
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67501707
93Renin-angiotensin system_Homo sapiens_hsa046140.67320541
94Regulation of autophagy_Homo sapiens_hsa041400.66027043
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65270854
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62943462
97Basal transcription factors_Homo sapiens_hsa030220.62793395
98Chemical carcinogenesis_Homo sapiens_hsa052040.62611093
99Mineral absorption_Homo sapiens_hsa049780.61317366
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60130348
101B cell receptor signaling pathway_Homo sapiens_hsa046620.58882955
102N-Glycan biosynthesis_Homo sapiens_hsa005100.54611637
103Phenylalanine metabolism_Homo sapiens_hsa003600.54102402
104Legionellosis_Homo sapiens_hsa051340.53561699
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51150852
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51039973
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50951960
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50009185
109Sphingolipid metabolism_Homo sapiens_hsa006000.47386891
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45746942
111Sulfur metabolism_Homo sapiens_hsa009200.45563474
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.44324297
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41558765
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41204578
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41202141
116Vibrio cholerae infection_Homo sapiens_hsa051100.39922802
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39784997
118Antigen processing and presentation_Homo sapiens_hsa046120.39399984
119Linoleic acid metabolism_Homo sapiens_hsa005910.39105830
120Epstein-Barr virus infection_Homo sapiens_hsa051690.37100987
121Insulin secretion_Homo sapiens_hsa049110.37090673
122Tyrosine metabolism_Homo sapiens_hsa003500.37077553
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36128766
124Type I diabetes mellitus_Homo sapiens_hsa049400.30516580
125p53 signaling pathway_Homo sapiens_hsa041150.28352596

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