RWDD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.67438526
2ATP synthesis coupled proton transport (GO:0015986)5.76074310
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.76074310
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.54179448
5L-phenylalanine catabolic process (GO:0006559)5.54179448
6protein neddylation (GO:0045116)5.48586940
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.20874402
8L-phenylalanine metabolic process (GO:0006558)5.20874402
9pyrimidine-containing compound salvage (GO:0008655)4.86714682
10pyrimidine nucleoside salvage (GO:0043097)4.86714682
11proteasome assembly (GO:0043248)4.86354664
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.82632451
13coenzyme catabolic process (GO:0009109)4.70132023
14aromatic amino acid family catabolic process (GO:0009074)4.68965197
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.61826452
16cellular ketone body metabolic process (GO:0046950)4.57080143
17glyoxylate metabolic process (GO:0046487)4.48201065
18mitochondrial DNA replication (GO:0006264)4.46697140
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.43252599
20sequestering of actin monomers (GO:0042989)4.38648089
21CENP-A containing nucleosome assembly (GO:0034080)4.25725923
22chromatin remodeling at centromere (GO:0031055)4.23490391
23viral transcription (GO:0019083)4.19684195
24respiratory electron transport chain (GO:0022904)4.17107730
25bile acid biosynthetic process (GO:0006699)4.16436347
26electron transport chain (GO:0022900)4.14886773
27translational termination (GO:0006415)4.13170338
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.11253072
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10677633
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.10677633
31NADH dehydrogenase complex assembly (GO:0010257)4.10677633
32protein complex biogenesis (GO:0070271)4.08356556
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.06563801
34cotranslational protein targeting to membrane (GO:0006613)4.05142556
35tryptophan catabolic process (GO:0006569)4.05060326
36indole-containing compound catabolic process (GO:0042436)4.05060326
37indolalkylamine catabolic process (GO:0046218)4.05060326
38chaperone-mediated protein transport (GO:0072321)4.01640966
39ribosomal small subunit assembly (GO:0000028)3.99488255
40tyrosine metabolic process (GO:0006570)3.96985817
41protein targeting to ER (GO:0045047)3.96619096
42ketone body metabolic process (GO:1902224)3.94591942
43nucleoside salvage (GO:0043174)3.92573550
44alpha-linolenic acid metabolic process (GO:0036109)3.89550355
45tryptophan metabolic process (GO:0006568)3.89303786
46mitochondrial respiratory chain complex assembly (GO:0033108)3.86167896
47negative regulation of dendrite development (GO:2000171)3.81216102
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.79515710
49protein localization to endoplasmic reticulum (GO:0070972)3.72691122
50kynurenine metabolic process (GO:0070189)3.70092249
51cellular glucuronidation (GO:0052695)3.68369822
52bile acid metabolic process (GO:0008206)3.67923860
53translational elongation (GO:0006414)3.63314149
54respiratory chain complex IV assembly (GO:0008535)3.60940179
55high-density lipoprotein particle remodeling (GO:0034375)3.60649363
56aromatic amino acid family metabolic process (GO:0009072)3.58946257
57fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.58727019
58organelle disassembly (GO:1903008)3.58263789
59cullin deneddylation (GO:0010388)3.58032973
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.56934631
61mitochondrial genome maintenance (GO:0000002)3.56828343
62cysteine metabolic process (GO:0006534)3.55320885
63sterol catabolic process (GO:0016127)3.54307097
64cholesterol catabolic process (GO:0006707)3.54307097
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.53587181
66cofactor catabolic process (GO:0051187)3.51466438
67regulation of fibrinolysis (GO:0051917)3.51245363
68imidazole-containing compound metabolic process (GO:0052803)3.50351380
69ethanol oxidation (GO:0006069)3.45387133
70histone exchange (GO:0043486)3.44559472
71aldehyde catabolic process (GO:0046185)3.43942617
72oxidative phosphorylation (GO:0006119)3.42359367
73ubiquinone biosynthetic process (GO:0006744)3.41254142
74quinone biosynthetic process (GO:1901663)3.41254142
75regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.41178016
76alpha-amino acid catabolic process (GO:1901606)3.39748541
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39701180
78negative regulation of fibrinolysis (GO:0051918)3.37704718
79sulfur amino acid catabolic process (GO:0000098)3.37166480
80translational initiation (GO:0006413)3.36320568
81protein deneddylation (GO:0000338)3.34863524
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33098628
83drug catabolic process (GO:0042737)3.31433282
84glucuronate metabolic process (GO:0019585)3.28058866
85uronic acid metabolic process (GO:0006063)3.28058866
86nucleotide transmembrane transport (GO:1901679)3.27903925
87lysine catabolic process (GO:0006554)3.27566965
88lysine metabolic process (GO:0006553)3.27566965
89negative regulation of protein oligomerization (GO:0032460)3.27540565
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27536041
91cellular modified amino acid catabolic process (GO:0042219)3.27031729
92viral life cycle (GO:0019058)3.23459852
93bile acid and bile salt transport (GO:0015721)3.22255026
94response to pheromone (GO:0019236)3.21229438
95serine family amino acid catabolic process (GO:0009071)3.21143506
96ATP biosynthetic process (GO:0006754)3.21003772
97amino-acid betaine metabolic process (GO:0006577)3.20235387
98dopamine transport (GO:0015872)3.19714682
99peroxisome fission (GO:0016559)3.19635919
100peptidyl-glutamic acid carboxylation (GO:0017187)3.18761828
101protein carboxylation (GO:0018214)3.18761828
102ribosomal large subunit biogenesis (GO:0042273)3.18544039
103cellular protein complex disassembly (GO:0043624)3.14084496
104neuron fate determination (GO:0048664)3.13661606
105platelet dense granule organization (GO:0060155)3.13509509
106glutamate metabolic process (GO:0006536)3.13390963
107reverse cholesterol transport (GO:0043691)3.13007661
108translation (GO:0006412)3.12634700
109pyrimidine nucleoside biosynthetic process (GO:0046134)3.12441291
110mitochondrial DNA metabolic process (GO:0032042)3.12335246
111cellular amino acid catabolic process (GO:0009063)3.11975917
112urea cycle (GO:0000050)3.11113829
113urea metabolic process (GO:0019627)3.11113829
114GTP biosynthetic process (GO:0006183)3.11068733
115negative regulation of ligase activity (GO:0051352)3.10983852
116negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10983852
117cytochrome complex assembly (GO:0017004)3.10017205
118DNA damage response, detection of DNA damage (GO:0042769)3.09974424
119spermatid nucleus differentiation (GO:0007289)3.09598694
120DNA replication-independent nucleosome organization (GO:0034724)3.07166595
121DNA replication-independent nucleosome assembly (GO:0006336)3.07166595
122anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.07089764
123rRNA modification (GO:0000154)3.06589731
124DNA ligation (GO:0006266)3.05450138
125DNA double-strand break processing (GO:0000729)3.04637776
126dicarboxylic acid catabolic process (GO:0043649)3.03241190
127indolalkylamine metabolic process (GO:0006586)3.02889868
128nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02626049
129intraciliary transport (GO:0042073)3.02595856
130tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00721140
131RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00721140
132DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.00360449
133otic vesicle formation (GO:0030916)3.00205438
134regulation of cellular amino acid metabolic process (GO:0006521)2.99284116
135polyketide metabolic process (GO:0030638)2.99035058
136doxorubicin metabolic process (GO:0044598)2.99035058
137daunorubicin metabolic process (GO:0044597)2.99035058
138acylglycerol homeostasis (GO:0055090)2.98679814
139triglyceride homeostasis (GO:0070328)2.98679814
140epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98638107
141opsonization (GO:0008228)2.97320488
142purine nucleoside triphosphate biosynthetic process (GO:0009145)2.97316282
143short-chain fatty acid metabolic process (GO:0046459)2.96974866
144regulation of protein activation cascade (GO:2000257)2.96864436
145protein-lipid complex remodeling (GO:0034368)2.96378698
146macromolecular complex remodeling (GO:0034367)2.96378698
147plasma lipoprotein particle remodeling (GO:0034369)2.96378698
148regulation of cholesterol biosynthetic process (GO:0045540)2.96094695
149signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95091116
150signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95091116
151signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95091116
152pyrimidine nucleobase metabolic process (GO:0006206)2.94931134
153DNA deamination (GO:0045006)2.94832694
154neuron remodeling (GO:0016322)2.94076262
155purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.93287080
156ubiquinone metabolic process (GO:0006743)2.93266308
157regulation of bile acid biosynthetic process (GO:0070857)2.91831993
158signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91040001
159intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91040001
160maturation of SSU-rRNA (GO:0030490)2.89275054
161steroid catabolic process (GO:0006706)2.88297649
162ribonucleoprotein complex disassembly (GO:0032988)2.87623157
163phospholipid efflux (GO:0033700)2.86364421
164striatum development (GO:0021756)2.85726387
165histone mRNA metabolic process (GO:0008334)2.84118161
166purine nucleobase biosynthetic process (GO:0009113)2.84081885
167epithelial cell differentiation involved in kidney development (GO:0035850)2.83843534
168quinone metabolic process (GO:1901661)2.83542282
169benzene-containing compound metabolic process (GO:0042537)2.82512464
170intracellular protein transmembrane import (GO:0044743)2.82230240
171transcription elongation from RNA polymerase III promoter (GO:0006385)2.82019564
172termination of RNA polymerase III transcription (GO:0006386)2.82019564
173regulation of glucokinase activity (GO:0033131)2.81985866
174regulation of hexokinase activity (GO:1903299)2.81985866
175flavonoid metabolic process (GO:0009812)2.81103866
176establishment of integrated proviral latency (GO:0075713)2.80734705
177deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.80222517
178regulation of cholesterol esterification (GO:0010872)2.80131367
179pyrimidine-containing compound transmembrane transport (GO:0072531)2.79861016
180response to nitrosative stress (GO:0051409)2.79577560
181pyrimidine nucleoside metabolic process (GO:0006213)2.77122285
182epithelial cilium movement (GO:0003351)2.76610074
183organic acid catabolic process (GO:0016054)2.76232789
184carboxylic acid catabolic process (GO:0046395)2.76232789
185anterograde synaptic vesicle transport (GO:0048490)2.75874830
186protein targeting to mitochondrion (GO:0006626)2.75407443
187centriole replication (GO:0007099)2.75342036
188signal transduction involved in cell cycle checkpoint (GO:0072395)2.75341109
189resolution of meiotic recombination intermediates (GO:0000712)2.74734201
190signal transduction involved in DNA damage checkpoint (GO:0072422)2.74704997
191signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74704997
192positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74647398
193regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74331154
194regulation of mitotic spindle checkpoint (GO:1903504)2.74331154
195detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73823569
196nitrogen cycle metabolic process (GO:0071941)2.73508888
197amine catabolic process (GO:0009310)2.72915698
198kinetochore assembly (GO:0051382)2.71764750
199inner mitochondrial membrane organization (GO:0007007)2.71239836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.55519590
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.90656032
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38930209
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.06113198
5* RXR_22158963_ChIP-Seq_LIVER_Mouse3.90384271
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.85537177
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.69655920
8GBX2_23144817_ChIP-Seq_PC3_Human3.43468405
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38632259
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.18650378
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.10904567
12ELK1_19687146_ChIP-ChIP_HELA_Human3.08947969
13* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.07685633
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.04852064
15TAF15_26573619_Chip-Seq_HEK293_Human3.03131846
16EZH2_22144423_ChIP-Seq_EOC_Human2.94304991
17* LXR_22158963_ChIP-Seq_LIVER_Mouse2.94162002
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94020557
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.89905715
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.74716960
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72857029
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.64997259
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51662296
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48213548
25* VDR_23849224_ChIP-Seq_CD4+_Human2.47137728
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35757348
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.27793794
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.21893832
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19558857
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16554855
31IGF1R_20145208_ChIP-Seq_DFB_Human2.02845146
32FOXP3_21729870_ChIP-Seq_TREG_Human1.94800282
33* P300_19829295_ChIP-Seq_ESCs_Human1.90444392
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88505608
35FUS_26573619_Chip-Seq_HEK293_Human1.83740234
36MYC_18940864_ChIP-ChIP_HL60_Human1.83249290
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81052606
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78053897
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77513786
40* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76947876
41* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75840920
42ZNF274_21170338_ChIP-Seq_K562_Hela1.75033481
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73676766
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70970090
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70659483
46GATA1_22025678_ChIP-Seq_K562_Human1.68634172
47* HTT_18923047_ChIP-ChIP_STHdh_Human1.66181887
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64425422
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63835129
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.60767361
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57457014
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49371616
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48016139
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47205289
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.43409661
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42945276
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42067866
58SMAD4_21799915_ChIP-Seq_A2780_Human1.41245199
59BCAT_22108803_ChIP-Seq_LS180_Human1.40375253
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40042720
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39361932
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37514806
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36479966
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35278121
65TTF2_22483619_ChIP-Seq_HELA_Human1.34918871
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.33420368
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33249779
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32239452
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31116039
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29802494
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29452227
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.28661211
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.28449129
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.27787655
75DCP1A_22483619_ChIP-Seq_HELA_Human1.26485215
76* SMAD3_21741376_ChIP-Seq_EPCs_Human1.25856311
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25571555
78VDR_22108803_ChIP-Seq_LS180_Human1.25041396
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.24256440
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24175259
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23903700
82* REST_21632747_ChIP-Seq_MESCs_Mouse1.23506026
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23476657
84NANOG_19829295_ChIP-Seq_ESCs_Human1.22472951
85SOX2_19829295_ChIP-Seq_ESCs_Human1.22472951
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22065760
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19596624
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19373671
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19149992
90JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18574126
91* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18217035
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17230521
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16764597
94EED_16625203_ChIP-ChIP_MESCs_Mouse1.16322428
95EZH2_27304074_Chip-Seq_ESCs_Mouse1.15851747
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15442554
97SRF_21415370_ChIP-Seq_HL-1_Mouse1.14558029
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14374554
99ELK1_22589737_ChIP-Seq_MCF10A_Human1.14203986
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13177573
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11362571
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.11033353
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10783766
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10747779
105* AR_25329375_ChIP-Seq_VCAP_Human1.10692215
106TP53_22573176_ChIP-Seq_HFKS_Human1.10163858
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.09581398
108SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09406075
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08810919
110HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08765962
111NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08578041
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08497988
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08468215
114RNF2_27304074_Chip-Seq_NSC_Mouse1.08041206
115* EWS_26573619_Chip-Seq_HEK293_Human1.08000562
116REST_18959480_ChIP-ChIP_MESCs_Mouse1.07667263
117* EZH2_27294783_Chip-Seq_ESCs_Mouse1.06954496
118* P53_22387025_ChIP-Seq_ESCs_Mouse1.06822794
119MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04570396
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04300944
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04220007
122XRN2_22483619_ChIP-Seq_HELA_Human1.04031181
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03438528
124ER_23166858_ChIP-Seq_MCF-7_Human1.03393837
125MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02172400
126* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02013470
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01627652
128TP53_18474530_ChIP-ChIP_U2OS_Human1.01493236
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99983980
130CMYC_18555785_Chip-Seq_ESCs_Mouse0.99750556
131FLI1_27457419_Chip-Seq_LIVER_Mouse0.99680240
132* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99495082
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98993382
134NOTCH1_21737748_ChIP-Seq_TLL_Human0.98904226
135TCF4_22108803_ChIP-Seq_LS180_Human0.98147599
136IRF1_19129219_ChIP-ChIP_H3396_Human0.97946483
137GABP_19822575_ChIP-Seq_HepG2_Human0.97041374
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.96576933
139TP63_19390658_ChIP-ChIP_HaCaT_Human0.96398024
140RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96320880
141CBP_20019798_ChIP-Seq_JUKART_Human0.95849428
142IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95849428
143EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95313450
144RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95313450
145FOXA1_25329375_ChIP-Seq_VCAP_Human0.94805504
146FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94805504
147SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94397548
148* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94385989
149EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93697614
150* E2F1_18555785_Chip-Seq_ESCs_Mouse0.93227775
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93116900
152FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93054573
153* SMAD4_21741376_ChIP-Seq_EPCs_Human0.92852704
154EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91911360
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91737740
156FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91638205
157JUN_21703547_ChIP-Seq_K562_Human0.91417001
158SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91308916
159KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91088583
160THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90350734
161PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90347005
162AR_20517297_ChIP-Seq_VCAP_Human0.90089921
163P300_18555785_Chip-Seq_ESCs_Mouse0.87907530
164* STAT3_18555785_Chip-Seq_ESCs_Mouse0.85087228
165SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84831482
166P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83761137
167CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83739647
168SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83736042
169TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83174328
170POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83174328

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.54043313
2MP0005360_urolithiasis4.64866922
3MP0005085_abnormal_gallbladder_physiolo4.56313823
4MP0005365_abnormal_bile_salt4.37574839
5MP0008875_abnormal_xenobiotic_pharmacok4.10301027
6MP0002102_abnormal_ear_morphology3.92654343
7MP0003136_yellow_coat_color3.32490129
8MP0000372_irregular_coat_pigmentation2.90583662
9MP0008058_abnormal_DNA_repair2.77080565
10MP0003806_abnormal_nucleotide_metabolis2.75775716
11MP0006072_abnormal_retinal_apoptosis2.61524619
12MP0003252_abnormal_bile_duct2.58519309
13MP0002938_white_spotting2.56165301
14MP0010329_abnormal_lipoprotein_level2.48200826
15MP0003195_calcinosis2.41779882
16MP0001293_anophthalmia2.31167933
17MP0008789_abnormal_olfactory_epithelium2.27914191
18MP0005646_abnormal_pituitary_gland2.21646938
19MP0009697_abnormal_copulation2.16980363
20MP0002638_abnormal_pupillary_reflex2.15977145
21MP0005248_abnormal_Harderian_gland2.04750394
22MP0001501_abnormal_sleep_pattern2.04149690
23MP0009379_abnormal_foot_pigmentation2.02517027
24MP0006035_abnormal_mitochondrial_morpho1.97845924
25MP0005332_abnormal_amino_acid1.96022389
26MP0010094_abnormal_chromosome_stability1.94224563
27MP0006276_abnormal_autonomic_nervous1.87164237
28MP0006036_abnormal_mitochondrial_physio1.86043951
29MP0005253_abnormal_eye_physiology1.85118874
30MP0003786_premature_aging1.82847152
31MP0004957_abnormal_blastocyst_morpholog1.79818726
32MP0010030_abnormal_orbit_morphology1.77655117
33MP0004133_heterotaxia1.75401290
34MP0005647_abnormal_sex_gland1.74927636
35MP0003186_abnormal_redox_activity1.73522069
36MP0005535_abnormal_body_temperature1.72696717
37MP0006292_abnormal_olfactory_placode1.69540784
38MP0003693_abnormal_embryo_hatching1.68720817
39MP0003890_abnormal_embryonic-extraembry1.66597636
40MP0002876_abnormal_thyroid_physiology1.61066065
41MP0004019_abnormal_vitamin_homeostasis1.58912696
42MP0003567_abnormal_fetal_cardiomyocyte1.58587055
43MP0002822_catalepsy1.54234121
44MP0003880_abnormal_central_pattern1.52513455
45MP0009745_abnormal_behavioral_response1.51528114
46MP0003011_delayed_dark_adaptation1.50348817
47MP0005084_abnormal_gallbladder_morpholo1.50344739
48MP0003868_abnormal_feces_composition1.49449581
49MP0008877_abnormal_DNA_methylation1.49315438
50MP0003635_abnormal_synaptic_transmissio1.47018122
51MP0005499_abnormal_olfactory_system1.46531947
52MP0005394_taste/olfaction_phenotype1.46531947
53MP0001905_abnormal_dopamine_level1.45987210
54MP0002118_abnormal_lipid_homeostasis1.45013540
55MP0002234_abnormal_pharynx_morphology1.44870695
56MP0001666_abnormal_nutrient_absorption1.44354774
57MP0005083_abnormal_biliary_tract1.44236853
58MP0003787_abnormal_imprinting1.37942252
59MP0002063_abnormal_learning/memory/cond1.35951374
60MP0002233_abnormal_nose_morphology1.35371988
61MP0003718_maternal_effect1.33928077
62MP0002282_abnormal_trachea_morphology1.33592691
63MP0001286_abnormal_eye_development1.32300622
64MP0001485_abnormal_pinna_reflex1.31570942
65MP0001529_abnormal_vocalization1.31521703
66MP0001764_abnormal_homeostasis1.31085973
67MP0002277_abnormal_respiratory_mucosa1.29198233
68MP0003937_abnormal_limbs/digits/tail_de1.27357618
69MP0002736_abnormal_nociception_after1.26612047
70MP0003119_abnormal_digestive_system1.26084282
71MP0002735_abnormal_chemical_nociception1.25007753
72MP0005171_absent_coat_pigmentation1.24475785
73MP0008932_abnormal_embryonic_tissue1.23587008
74MP0004215_abnormal_myocardial_fiber1.23320301
75MP0002653_abnormal_ependyma_morphology1.20369610
76MP0001968_abnormal_touch/_nociception1.17959750
77MP0003077_abnormal_cell_cycle1.17538546
78MP0004142_abnormal_muscle_tone1.17473096
79MP0002837_dystrophic_cardiac_calcinosis1.16694574
80MP0001984_abnormal_olfaction1.13779440
81MP0002751_abnormal_autonomic_nervous1.12988955
82MP0001440_abnormal_grooming_behavior1.11823474
83MP0001919_abnormal_reproductive_system1.11511355
84MP0004859_abnormal_synaptic_plasticity1.11433117
85MP0004924_abnormal_behavior1.11412370
86MP0005386_behavior/neurological_phenoty1.11412370
87MP0002064_seizures1.11061275
88MP0002572_abnormal_emotion/affect_behav1.10597448
89MP0001502_abnormal_circadian_rhythm1.10334550
90MP0005391_vision/eye_phenotype1.09146106
91MP0000609_abnormal_liver_physiology1.06966583
92MP0003656_abnormal_erythrocyte_physiolo1.06219807
93MP0000049_abnormal_middle_ear1.06113022
94MP0005319_abnormal_enzyme/_coenzyme1.05775574
95MP0010368_abnormal_lymphatic_system1.05647834
96MP0009046_muscle_twitch1.04864216
97MP0006054_spinal_hemorrhage1.04736606
98MP0002078_abnormal_glucose_homeostasis1.03784745
99MP0000383_abnormal_hair_follicle1.01514364
100MP0000647_abnormal_sebaceous_gland1.00693089
101MP0003122_maternal_imprinting1.00317112
102MP0002909_abnormal_adrenal_gland1.00057114
103MP0004145_abnormal_muscle_electrophysio0.99378290
104MP0005423_abnormal_somatic_nervous0.99083381
105MP0005389_reproductive_system_phenotype0.98785977
106MP0002067_abnormal_sensory_capabilities0.95632294
107MP0002132_abnormal_respiratory_system0.93607000
108MP0002272_abnormal_nervous_system0.93599758
109MP0005584_abnormal_enzyme/coenzyme_acti0.93102366
110MP0003938_abnormal_ear_development0.92160080
111MP0003111_abnormal_nucleus_morphology0.92013126
112MP0003137_abnormal_impulse_conducting0.90626496
113MP0002095_abnormal_skin_pigmentation0.90551868
114MP0005367_renal/urinary_system_phenotyp0.90343998
115MP0000516_abnormal_urinary_system0.90343998
116MP0008007_abnormal_cellular_replicative0.89972351
117MP0001929_abnormal_gametogenesis0.89681838
118MP0004147_increased_porphyrin_level0.89513964
119MP0005195_abnormal_posterior_eye0.89069464
120MP0001986_abnormal_taste_sensitivity0.88365231
121MP0005408_hypopigmentation0.88137007
122MP0002971_abnormal_brown_adipose0.87687582
123MP0008872_abnormal_physiological_respon0.87622416
124MP0000537_abnormal_urethra_morphology0.87495394
125MP0005636_abnormal_mineral_homeostasis0.86975376
126MP0002210_abnormal_sex_determination0.86969331
127MP0010234_abnormal_vibrissa_follicle0.86327643
128MP0000566_synostosis0.86181102
129MP0000653_abnormal_sex_gland0.85527044
130MP0001119_abnormal_female_reproductive0.85110319
131MP0002069_abnormal_eating/drinking_beha0.84841834
132MP0005645_abnormal_hypothalamus_physiol0.84449298
133MP0003121_genomic_imprinting0.83903648
134MP0003632_abnormal_nervous_system0.82846836
135MP0003315_abnormal_perineum_morphology0.82761380
136MP0001486_abnormal_startle_reflex0.82745507
137MP0001188_hyperpigmentation0.82236093
138MP0000639_abnormal_adrenal_gland0.81952252
139MP0004130_abnormal_muscle_cell0.81756458
140MP0001324_abnormal_eye_pigmentation0.81098279
141MP0002557_abnormal_social/conspecific_i0.80689037
142MP0002734_abnormal_mechanical_nocicepti0.80322025
143MP0003283_abnormal_digestive_organ0.80038948
144MP0003953_abnormal_hormone_level0.79679974
145MP0001944_abnormal_pancreas_morphology0.79587583
146MP0002928_abnormal_bile_duct0.78736761
147MP0003631_nervous_system_phenotype0.78085263
148MP0000749_muscle_degeneration0.77653122
149MP0001145_abnormal_male_reproductive0.76388111
150MP0002090_abnormal_vision0.75458559
151MP0000613_abnormal_salivary_gland0.75215476
152MP0005448_abnormal_energy_balance0.74746598
153MP0000534_abnormal_ureter_morphology0.74647633
154MP0005551_abnormal_eye_electrophysiolog0.74367077
155MP0008004_abnormal_stomach_pH0.73978723
156MP0000631_abnormal_neuroendocrine_gland0.73448780
157MP0002697_abnormal_eye_size0.73297391
158MP0002184_abnormal_innervation0.73237136
159MP0000955_abnormal_spinal_cord0.73182168
160MP0000026_abnormal_inner_ear0.71399521
161MP0005187_abnormal_penis_morphology0.71359954
162MP0005075_abnormal_melanosome_morpholog0.71076168
163MP0003633_abnormal_nervous_system0.70901883
164MP0002249_abnormal_larynx_morphology0.69321327
165MP0003941_abnormal_skin_development0.68912850
166MP0008995_early_reproductive_senescence0.68676638
167MP0005334_abnormal_fat_pad0.67862633
168MP0004085_abnormal_heartbeat0.66008021

Predicted human phenotypes

RankGene SetZ-score
1Progressive inability to walk (HP:0002505)5.73317350
2Abnormality of the heme biosynthetic pathway (HP:0010472)5.08782213
3Ragged-red muscle fibers (HP:0003200)5.07729108
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.80992921
5Decreased activity of mitochondrial respiratory chain (HP:0008972)4.58671079
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.58671079
7Intrahepatic cholestasis (HP:0001406)4.43082721
8Facial diplegia (HP:0001349)4.14421332
9Prolonged partial thromboplastin time (HP:0003645)4.10010362
10Hypobetalipoproteinemia (HP:0003563)4.01591529
11Hepatocellular necrosis (HP:0001404)3.78493015
12Deep venous thrombosis (HP:0002625)3.58774316
13Inability to walk (HP:0002540)3.58421120
14Ketosis (HP:0001946)3.52914252
15Increased hepatocellular lipid droplets (HP:0006565)3.45656540
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.33542084
17Abnormal ciliary motility (HP:0012262)3.28931095
18Pancreatic cysts (HP:0001737)3.26939231
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.26848918
20Hypochromic microcytic anemia (HP:0004840)3.24712648
21Ketoacidosis (HP:0001993)3.24416022
22True hermaphroditism (HP:0010459)3.19248183
23Lipid accumulation in hepatocytes (HP:0006561)3.07609120
24Abnormal respiratory motile cilium physiology (HP:0012261)3.05518583
25Hyperventilation (HP:0002883)3.04275959
26Hyperlipoproteinemia (HP:0010980)3.03675868
27Conjugated hyperbilirubinemia (HP:0002908)3.03250429
28Hyperglycinuria (HP:0003108)3.02503248
29Delayed gross motor development (HP:0002194)3.01686387
30Focal motor seizures (HP:0011153)2.99226186
31Xanthomatosis (HP:0000991)2.99214896
32Pancreatic fibrosis (HP:0100732)2.99088021
33Renal Fanconi syndrome (HP:0001994)2.98483167
34Hypoglycemic coma (HP:0001325)2.97089950
35Colon cancer (HP:0003003)2.96124399
36Cerebral edema (HP:0002181)2.94666654
37Spontaneous abortion (HP:0005268)2.93101535
38Hypolipoproteinemia (HP:0010981)2.86512147
39Abnormality of glycine metabolism (HP:0010895)2.84841926
40Abnormality of serine family amino acid metabolism (HP:0010894)2.84841926
41Septo-optic dysplasia (HP:0100842)2.84156626
42Hyperammonemia (HP:0001987)2.81972494
43Hyperglycinemia (HP:0002154)2.78178045
44Hypoglycemic seizures (HP:0002173)2.67550528
45Abnormal respiratory motile cilium morphology (HP:0005938)2.66270549
46Abnormal respiratory epithelium morphology (HP:0012253)2.66270549
47Acute encephalopathy (HP:0006846)2.65044578
48Medial flaring of the eyebrow (HP:0010747)2.63720495
493-Methylglutaconic aciduria (HP:0003535)2.60820971
50Renal cortical cysts (HP:0000803)2.59331058
51Supernumerary spleens (HP:0009799)2.55305821
52Irritability (HP:0000737)2.53191712
53Methylmalonic acidemia (HP:0002912)2.51685510
54Molar tooth sign on MRI (HP:0002419)2.49394239
55Abnormality of midbrain morphology (HP:0002418)2.49394239
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.48664647
57Abnormality of methionine metabolism (HP:0010901)2.48068867
58Rhinitis (HP:0012384)2.46798284
59Abnormality of the intrinsic pathway (HP:0010989)2.46113129
60Stenosis of the external auditory canal (HP:0000402)2.45555183
61Acute necrotizing encephalopathy (HP:0006965)2.45299357
62Lethargy (HP:0001254)2.45291725
63Hypercholesterolemia (HP:0003124)2.44903091
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.41521438
65Lactic acidosis (HP:0003128)2.40763110
66Abnormal number of erythroid precursors (HP:0012131)2.40311562
67Macrocytic anemia (HP:0001972)2.40112990
68Hyperbilirubinemia (HP:0002904)2.40052716
69Absent septum pellucidum (HP:0001331)2.40011538
70Abnormality of the labia minora (HP:0012880)2.39568782
71Congenital, generalized hypertrichosis (HP:0004540)2.38771279
72Hypoalphalipoproteinemia (HP:0003233)2.38560485
73Reticulocytopenia (HP:0001896)2.37154762
74Congenital primary aphakia (HP:0007707)2.36648245
75Increased intramyocellular lipid droplets (HP:0012240)2.36418458
76Increased serum lactate (HP:0002151)2.32875735
77Abnormal mitochondria in muscle tissue (HP:0008316)2.32019891
78Hypothermia (HP:0002045)2.32007283
79Sensorimotor neuropathy (HP:0007141)2.27719804
80Metabolic acidosis (HP:0001942)2.27168909
81Exertional dyspnea (HP:0002875)2.25992314
82Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25796707
83Opisthotonus (HP:0002179)2.25551964
84Optic disc pallor (HP:0000543)2.24671364
85Proximal tubulopathy (HP:0000114)2.22617435
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22567899
87Dicarboxylic aciduria (HP:0003215)2.22567899
88Short tibia (HP:0005736)2.21243206
89Abnormality of the common coagulation pathway (HP:0010990)2.19942202
90Nephronophthisis (HP:0000090)2.19351907
91Abnormality of the phalanges of the 2nd finger (HP:0009541)2.19220382
92Abnormality of serum amino acid levels (HP:0003112)2.19092870
93Gait imbalance (HP:0002141)2.18530556
94Respiratory failure (HP:0002878)2.18473117
95Vaginal atresia (HP:0000148)2.18284655
96Abnormality of cells of the erythroid lineage (HP:0012130)2.17197468
97Nephrogenic diabetes insipidus (HP:0009806)2.16965287
98Abnormal pancreas size (HP:0012094)2.14935606
99Intellectual disability, progressive (HP:0006887)2.14558565
100Abnormality of renal resorption (HP:0011038)2.14217467
101Abnormal gallbladder physiology (HP:0012438)2.13265525
102Cholecystitis (HP:0001082)2.13265525
103Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12672248
104Genital tract atresia (HP:0001827)2.12651034
105Abnormality of sulfur amino acid metabolism (HP:0004339)2.12595607
106Enlarged kidneys (HP:0000105)2.08795957
107Symptomatic seizures (HP:0011145)2.08722543
108Epidermoid cyst (HP:0200040)2.08083217
109Exercise-induced muscle cramps (HP:0003710)2.07999337
110Visual hallucinations (HP:0002367)2.07539030
111Type I transferrin isoform profile (HP:0003642)2.07186977
112Abnormality of the septum pellucidum (HP:0007375)2.06190547
113Protruding tongue (HP:0010808)2.05640855
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04963117
115Abnormal protein N-linked glycosylation (HP:0012347)2.04963117
116Abnormal protein glycosylation (HP:0012346)2.04963117
117Abnormal glycosylation (HP:0012345)2.04963117
118Fat malabsorption (HP:0002630)2.04316650
119Respiratory difficulties (HP:0002880)2.04165343
120Exercise intolerance (HP:0003546)2.03815963
121Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03338520
122Joint hemorrhage (HP:0005261)2.02818140
123Aplasia/Hypoplasia of the tibia (HP:0005772)2.00192169
124Congenital stationary night blindness (HP:0007642)1.99239022
125Osteomalacia (HP:0002749)1.98681532
126Abnormality of the renal cortex (HP:0011035)1.98245061
127Progressive macrocephaly (HP:0004481)1.98103088
128Chronic hepatic failure (HP:0100626)1.97774952
129Anencephaly (HP:0002323)1.97050462
130Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97039461
131Abnormality of fatty-acid metabolism (HP:0004359)1.96869685
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.96672947
133Skin nodule (HP:0200036)1.96073024
134Hypoplastic pelvis (HP:0008839)1.95644961
135Hepatic necrosis (HP:0002605)1.95232054
136Leukodystrophy (HP:0002415)1.94863375
137Abnormality of the fovea (HP:0000493)1.94680749
138Methylmalonic aciduria (HP:0012120)1.94260516
139Aplastic anemia (HP:0001915)1.94245053
140Esophageal atresia (HP:0002032)1.93362622
141Gout (HP:0001997)1.92273387
142Abnormality of alanine metabolism (HP:0010916)1.92098199
143Hyperalaninemia (HP:0003348)1.92098199
144Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92098199
145Vomiting (HP:0002013)1.91522554
146Abnormality of urine glucose concentration (HP:0011016)1.91507818
147Glycosuria (HP:0003076)1.91507818
148Triphalangeal thumb (HP:0001199)1.91207449
149Male pseudohermaphroditism (HP:0000037)1.90900569
150Generalized aminoaciduria (HP:0002909)1.89194044
151Increased CSF lactate (HP:0002490)1.88279385
152Hyperglycemia (HP:0003074)1.87980332
153Type 2 muscle fiber atrophy (HP:0003554)1.87967428
154Delayed CNS myelination (HP:0002188)1.87577583
155Intestinal atresia (HP:0011100)1.87568234
156Abnormality of the renal medulla (HP:0100957)1.87488992
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.87472791
158Increased serum pyruvate (HP:0003542)1.87292413
159Optic nerve hypoplasia (HP:0000609)1.87105853
160Sclerocornea (HP:0000647)1.86457987
161Complement deficiency (HP:0004431)1.86008096
162Abnormal lung lobation (HP:0002101)1.85660837
163Thyroid-stimulating hormone excess (HP:0002925)1.85240756
164Brushfield spots (HP:0001088)1.84868212
165Abnormal biliary tract physiology (HP:0012439)1.84589248
166Bile duct proliferation (HP:0001408)1.84589248
167Epileptiform EEG discharges (HP:0011182)1.83656329
168Febrile seizures (HP:0002373)1.82937399
169EEG with generalized epileptiform discharges (HP:0011198)1.81256539
170Epileptic encephalopathy (HP:0200134)1.81132322
171Limb hypertonia (HP:0002509)1.80737187
172Mitochondrial inheritance (HP:0001427)1.80552122
173Bicornuate uterus (HP:0000813)1.79376565

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.28632712
2NTRK33.10931665
3SIK12.91312078
4FLT32.88914170
5TRIM282.67978085
6BCKDK2.67708144
7MAP3K122.62528675
8MAP2K72.54925809
9VRK22.54252297
10SRPK12.52636852
11INSRR2.47274061
12MAP2K42.45676994
13CASK2.40915523
14DYRK1A2.33268295
15ZAK2.31865032
16MST42.30325455
17MAP3K42.26842580
18SGK22.26280694
19MAPK152.18487508
20CAMKK22.18012635
21WNK32.17556941
22ARAF2.14526337
23TAOK22.09491796
24VRK12.09225008
25NEK12.04315848
26MKNK11.98829414
27MUSK1.91831243
28PLK41.90846060
29EIF2AK31.90470583
30NUAK11.87050307
31PLK31.77533498
32BCR1.76556929
33MAP3K91.74976331
34CDC71.74075055
35NME11.73702712
36ADRBK21.73222334
37WEE11.72557300
38MAPK131.66817187
39SGK31.61618816
40EIF2AK11.54956100
41TLK11.53803543
42EPHA41.52560403
43SGK2231.50821468
44SGK4941.50821468
45MAP4K21.50593620
46MKNK21.50498267
47ERBB31.48413503
48PLK21.46656986
49GRK51.43390798
50AKT31.39710735
51FGFR31.38763438
52CDK81.36735777
53MARK11.34293292
54PBK1.33830138
55PASK1.32324425
56FRK1.30996518
57PINK11.25650613
58PDK21.23286963
59MYLK1.22997791
60CCNB11.21876984
61TIE11.21542211
62MAPK71.18474501
63BMPR1B1.14709572
64MAP2K61.14198973
65CAMK2B1.13586065
66TSSK61.13330515
67MINK11.12343375
68STK391.10854316
69GRK61.07931105
70ACVR1B1.07837979
71TTK1.06888004
72MAPKAPK51.06571276
73PRKCG1.05778209
74DYRK1B1.05092715
75OXSR11.04404149
76TEC1.03336615
77ERBB41.01544785
78STK161.01402430
79PIK3CA1.01058840
80TNIK1.00690165
81PLK11.00095366
82CDK30.99198829
83BRSK20.97815995
84KDR0.95794912
85BRAF0.95701435
86GRK70.95341318
87TXK0.93791439
88OBSCN0.92311204
89MAPK120.87131749
90DAPK10.86071249
91CDK190.84752699
92DYRK20.83670527
93TESK20.81196589
94SIK30.81020265
95NEK20.80502965
96FGFR20.79514369
97CAMK2A0.78707757
98GRK10.77014708
99CLK10.75588183
100CSNK1G30.75111666
101PRPF4B0.74522979
102PTK2B0.73613092
103EPHA30.71996424
104MAP2K30.71428423
105HIPK20.69385303
106RPS6KA40.68653427
107CAMK2G0.67328892
108AURKB0.66173792
109SIK20.65816154
110FES0.65498794
111WNK40.63122521
112PRKCE0.62813237
113CSNK1G20.61993876
114FGFR40.61580581
115PNCK0.61467278
116CAMK10.61407084
117CSNK1G10.61384676
118RPS6KB10.57508665
119CSNK2A10.57322294
120PIK3CG0.56574823
121RPS6KB20.55712704
122CSNK2A20.55115793
123CAMK2D0.54697683
124SYK0.54226645
125EIF2AK20.53839693
126UHMK10.53654590
127CSF1R0.53174414
128ATR0.53069341
129TGFBR10.52462813
130PRKAA20.52067789
131PHKG20.51526556
132PHKG10.51526556
133RPS6KA50.50768040
134MAP3K130.49221947
135ADRBK10.48480084
136PRKACA0.48309144
137CAMKK10.47448627
138MAPK40.46847819
139ABL20.46844377
140CDK50.46575807
141STK40.45999495
142DAPK20.45588946
143FGFR10.43967575
144PRKACG0.42707780
145NTRK20.41751352
146ERBB20.41684377
147BMPR20.39703426
148EPHB20.39500161
149NLK0.39387643
150STK30.39234608
151STK38L0.39020286
152CAMK40.37798405
153DYRK30.36228136
154LIMK10.36183350
155CSNK1A1L0.35605783
156CHEK20.33493568
157ATM0.32908414
158PAK30.32681541
159PRKACB0.30117718
160KIT0.29743857
161TAF10.29129667
162TNK20.28830896
163PRKCH0.28211871

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.91374759
2Proteasome_Homo sapiens_hsa030503.90013037
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.84181320
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95112979
5Drug metabolism - other enzymes_Homo sapiens_hsa009832.77581783
6Mismatch repair_Homo sapiens_hsa034302.69339845
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68567274
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63895296
9Butanoate metabolism_Homo sapiens_hsa006502.54815324
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52346478
11RNA polymerase_Homo sapiens_hsa030202.26106820
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26079723
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19884645
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16420509
15Propanoate metabolism_Homo sapiens_hsa006402.14237142
16Homologous recombination_Homo sapiens_hsa034402.12951544
17Fatty acid degradation_Homo sapiens_hsa000712.11281620
18Tryptophan metabolism_Homo sapiens_hsa003802.10775879
19Peroxisome_Homo sapiens_hsa041462.08856415
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07513275
21Selenocompound metabolism_Homo sapiens_hsa004502.07502445
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98138440
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95109440
24Arginine biosynthesis_Homo sapiens_hsa002201.91597394
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.89469664
26DNA replication_Homo sapiens_hsa030301.87061572
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.85684372
28Spliceosome_Homo sapiens_hsa030401.83097676
29Fanconi anemia pathway_Homo sapiens_hsa034601.80011193
30Pyruvate metabolism_Homo sapiens_hsa006201.79783628
31Chemical carcinogenesis_Homo sapiens_hsa052041.78655321
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77823397
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76712061
34Complement and coagulation cascades_Homo sapiens_hsa046101.76019941
35Nitrogen metabolism_Homo sapiens_hsa009101.71733065
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69934910
37Nucleotide excision repair_Homo sapiens_hsa034201.67833577
38Tyrosine metabolism_Homo sapiens_hsa003501.67042318
39RNA degradation_Homo sapiens_hsa030181.65280572
40beta-Alanine metabolism_Homo sapiens_hsa004101.65271582
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62708696
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56215974
43Histidine metabolism_Homo sapiens_hsa003401.55559848
44Retinol metabolism_Homo sapiens_hsa008301.48162400
45Basal transcription factors_Homo sapiens_hsa030221.47994008
46Oxidative phosphorylation_Homo sapiens_hsa001901.45126338
47Sulfur metabolism_Homo sapiens_hsa009201.43240785
48Non-homologous end-joining_Homo sapiens_hsa034501.42645073
49Phenylalanine metabolism_Homo sapiens_hsa003601.42058110
50Steroid biosynthesis_Homo sapiens_hsa001001.41946019
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38177011
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38047403
53RNA transport_Homo sapiens_hsa030131.36851657
54ABC transporters_Homo sapiens_hsa020101.34620637
55Starch and sucrose metabolism_Homo sapiens_hsa005001.34377101
56Fatty acid metabolism_Homo sapiens_hsa012121.30800359
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25433905
58PPAR signaling pathway_Homo sapiens_hsa033201.24777919
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22174320
60Taste transduction_Homo sapiens_hsa047421.21047221
61Nicotine addiction_Homo sapiens_hsa050331.18172319
62Linoleic acid metabolism_Homo sapiens_hsa005911.17249384
63Base excision repair_Homo sapiens_hsa034101.17101274
64Parkinsons disease_Homo sapiens_hsa050121.16329494
65Bile secretion_Homo sapiens_hsa049761.13341377
66Fatty acid elongation_Homo sapiens_hsa000621.13049584
67Purine metabolism_Homo sapiens_hsa002301.11495723
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.07902547
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00687776
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99190050
71Carbon metabolism_Homo sapiens_hsa012000.96778809
72Phototransduction_Homo sapiens_hsa047440.95098025
73Collecting duct acid secretion_Homo sapiens_hsa049660.90307667
74Protein export_Homo sapiens_hsa030600.90171363
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89265464
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87517074
77Cell cycle_Homo sapiens_hsa041100.84892073
78GABAergic synapse_Homo sapiens_hsa047270.84470212
79Biosynthesis of amino acids_Homo sapiens_hsa012300.83512549
80Alzheimers disease_Homo sapiens_hsa050100.78655144
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77664455
82Huntingtons disease_Homo sapiens_hsa050160.75524460
83Regulation of autophagy_Homo sapiens_hsa041400.75243277
84Pyrimidine metabolism_Homo sapiens_hsa002400.74970654
85Metabolic pathways_Homo sapiens_hsa011000.72462073
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72258882
87Caffeine metabolism_Homo sapiens_hsa002320.70767163
88Basal cell carcinoma_Homo sapiens_hsa052170.69514622
89Arginine and proline metabolism_Homo sapiens_hsa003300.62304547
90Synaptic vesicle cycle_Homo sapiens_hsa047210.61734709
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61341889
92Folate biosynthesis_Homo sapiens_hsa007900.60313064
93Hedgehog signaling pathway_Homo sapiens_hsa043400.56538271
94One carbon pool by folate_Homo sapiens_hsa006700.55036107
95Arachidonic acid metabolism_Homo sapiens_hsa005900.54364168
96Primary immunodeficiency_Homo sapiens_hsa053400.52629520
97Glucagon signaling pathway_Homo sapiens_hsa049220.51954879
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51515457
99Sulfur relay system_Homo sapiens_hsa041220.50636810
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50403961
101Fat digestion and absorption_Homo sapiens_hsa049750.50258803
102Fructose and mannose metabolism_Homo sapiens_hsa000510.50258605
103Morphine addiction_Homo sapiens_hsa050320.50013547
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49369042
105Oocyte meiosis_Homo sapiens_hsa041140.49284298
106Ovarian steroidogenesis_Homo sapiens_hsa049130.49189950
107Glycerolipid metabolism_Homo sapiens_hsa005610.49043446
108Ether lipid metabolism_Homo sapiens_hsa005650.48936940
109Amphetamine addiction_Homo sapiens_hsa050310.47224448
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46851892
111Circadian rhythm_Homo sapiens_hsa047100.46475864
112Circadian entrainment_Homo sapiens_hsa047130.44535433
113Olfactory transduction_Homo sapiens_hsa047400.44417382
114Cocaine addiction_Homo sapiens_hsa050300.44403973
115Insulin secretion_Homo sapiens_hsa049110.44250530
116Staphylococcus aureus infection_Homo sapiens_hsa051500.44161342
117TGF-beta signaling pathway_Homo sapiens_hsa043500.42472379
118mRNA surveillance pathway_Homo sapiens_hsa030150.41890416
119Vitamin digestion and absorption_Homo sapiens_hsa049770.41638236
120Galactose metabolism_Homo sapiens_hsa000520.41401167
121Vibrio cholerae infection_Homo sapiens_hsa051100.41063125
122p53 signaling pathway_Homo sapiens_hsa041150.38812313
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38227308
124Prion diseases_Homo sapiens_hsa050200.36131252
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35415314
126Serotonergic synapse_Homo sapiens_hsa047260.34056173
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32856527
128Wnt signaling pathway_Homo sapiens_hsa043100.32469155
129Glutamatergic synapse_Homo sapiens_hsa047240.30286033
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29574195
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29347224
132Dopaminergic synapse_Homo sapiens_hsa047280.28084549
133Systemic lupus erythematosus_Homo sapiens_hsa053220.28005611
134Vitamin B6 metabolism_Homo sapiens_hsa007500.25382093
135Glutathione metabolism_Homo sapiens_hsa004800.24350334
136Insulin resistance_Homo sapiens_hsa049310.23074886
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23026112
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22759328
139Cardiac muscle contraction_Homo sapiens_hsa042600.21879320
140Calcium signaling pathway_Homo sapiens_hsa040200.21864269
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21018381
142N-Glycan biosynthesis_Homo sapiens_hsa005100.19354412

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