ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adenosine metabolic process (GO:0046085)	5.44915748
2	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.94663061
3	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.94663061
4	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.63955785
5	NADH dehydrogenase complex assembly (GO:0010257)	4.63955785
6	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.63955785
7	platelet dense granule organization (GO:0060155)	4.60357125
8	negative regulation of acute inflammatory response (GO:0002674)	4.56431472
9	purine nucleotide salvage (GO:0032261)	4.44681968
10	folic acid-containing compound biosynthetic process (GO:0009396)	4.38031422
11	cell wall macromolecule metabolic process (GO:0044036)	4.14856255
12	chaperone-mediated protein transport (GO:0072321)	4.04694772
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.01903558
14	cysteine metabolic process (GO:0006534)	4.00185840
15	peptidyl-histidine modification (GO:0018202)	3.80386421
16	cell wall macromolecule catabolic process (GO:0016998)	3.79788418
17	behavioral response to nicotine (GO:0035095)	3.76152084
18	homocysteine metabolic process (GO:0050667)	3.74655632
19	GMP metabolic process (GO:0046037)	3.73183186
20	protein-cofactor linkage (GO:0018065)	3.68076122
21	preassembly of GPI anchor in ER membrane (GO:0016254)	3.64757733
22	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.63214612
23	protein complex biogenesis (GO:0070271)	3.61571431
24	alkaloid metabolic process (GO:0009820)	3.44820384
25	artery smooth muscle contraction (GO:0014824)	3.40230599
26	regulation of plasminogen activation (GO:0010755)	3.37627476
27	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.35129755
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.26981109
29	sulfur amino acid catabolic process (GO:0000098)	3.24806378
30	respiratory electron transport chain (GO:0022904)	3.24525254
31	microtubule nucleation (GO:0007020)	3.20455943
32	protein neddylation (GO:0045116)	3.19303884
33	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.16669928
34	ATP synthesis coupled proton transport (GO:0015986)	3.16669928
35	electron transport chain (GO:0022900)	3.16627822
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.14809213
37	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.10644193
38	CENP-A containing nucleosome assembly (GO:0034080)	3.06601601
39	retinal ganglion cell axon guidance (GO:0031290)	3.06303364
40	pseudouridine synthesis (GO:0001522)	3.04762384
41	mitochondrial RNA metabolic process (GO:0000959)	3.04352271
42	pteridine-containing compound biosynthetic process (GO:0042559)	3.02731073
43	rRNA modification (GO:0000154)	3.02235636
44	DNA deamination (GO:0045006)	3.00814679
45	rRNA methylation (GO:0031167)	2.97589172
46	chromatin remodeling at centromere (GO:0031055)	2.97357239
47	nonmotile primary cilium assembly (GO:0035058)	2.96621772
48	proteasome assembly (GO:0043248)	2.96373510
49	tRNA processing (GO:0008033)	2.94075408
50	negative regulation of interleukin-1 beta production (GO:0032691)	2.91398364
51	autophagic vacuole fusion (GO:0000046)	2.89874143
52	alternative mRNA splicing, via spliceosome (GO:0000380)	2.89834818
53	positive regulation of histone H3-K4 methylation (GO:0051571)	2.86590943
54	amino acid salvage (GO:0043102)	2.82077878
55	L-methionine salvage (GO:0071267)	2.82077878
56	L-methionine biosynthetic process (GO:0071265)	2.82077878
57	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.82015351
58	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.82015351
59	negative regulation of interleukin-1 production (GO:0032692)	2.80015713
60	tRNA modification (GO:0006400)	2.78585003
61	serotonin receptor signaling pathway (GO:0007210)	2.78126233
62	adult feeding behavior (GO:0008343)	2.77127447
63	purine-containing compound salvage (GO:0043101)	2.76407648
64	C-terminal protein amino acid modification (GO:0018410)	2.75614395
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.74375705
66	tonic smooth muscle contraction (GO:0014820)	2.72359462
67	inner mitochondrial membrane organization (GO:0007007)	2.70463706
68	interferon-gamma production (GO:0032609)	2.69403935
69	cochlea development (GO:0090102)	2.68035858
70	L-serine metabolic process (GO:0006563)	2.67262877
71	water-soluble vitamin biosynthetic process (GO:0042364)	2.66639238
72	histone H3-K4 trimethylation (GO:0080182)	2.64805598
73	GPI anchor biosynthetic process (GO:0006506)	2.63987343
74	GPI anchor metabolic process (GO:0006505)	2.63269488
75	DNA replication-independent nucleosome assembly (GO:0006336)	2.62166764
76	DNA replication-independent nucleosome organization (GO:0034724)	2.62166764
77	sulfur amino acid biosynthetic process (GO:0000097)	2.62095102
78	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.60622752
79	dopamine biosynthetic process (GO:0042416)	2.59732289
80	positive regulation of endothelial cell differentiation (GO:0045603)	2.58202930
81	positive regulation by host of viral transcription (GO:0043923)	2.57918429
82	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.57751136
83	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.56388018
84	inner ear receptor cell development (GO:0060119)	2.55396325
85	polyamine metabolic process (GO:0006595)	2.55281334
86	regulation of isotype switching to IgG isotypes (GO:0048302)	2.53706316
87	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.52348346
88	negative regulation of mast cell activation (GO:0033004)	2.51508013
89	neutrophil activation involved in immune response (GO:0002283)	2.50977090
90	regulation of MHC class II biosynthetic process (GO:0045346)	2.47520215
91	anterograde synaptic vesicle transport (GO:0048490)	2.46927991
92	regulation of sequestering of triglyceride (GO:0010889)	2.44721567
93	multicellular organismal aging (GO:0010259)	2.44334859
94	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.43241824
95	histone exchange (GO:0043486)	2.42564229
96	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.42084983
97	regulation of mitotic spindle checkpoint (GO:1903504)	2.42084983
98	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.41860667
99	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.40727671
100	guanosine-containing compound biosynthetic process (GO:1901070)	2.40632647

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.40099084
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.42159907
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.51220875
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.12439444
5	VDR_22108803_ChIP-Seq_LS180_Human	3.08756562
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.63136326
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.62040074
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.53186061
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51552749
10	FUS_26573619_Chip-Seq_HEK293_Human	2.44884168
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.34630747
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.30800124
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.29548504
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.25053917
15	EWS_26573619_Chip-Seq_HEK293_Human	2.21603248
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.20335032
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.14629124
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.12361621
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.04119596
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03252759
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00497199
22	P300_19829295_ChIP-Seq_ESCs_Human	1.97058376
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94834852
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.89848070
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.89042130
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.83559639
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.83495835
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.77660792
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.69488501
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.65028085
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54201853
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.54201853
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53097495
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.53086477
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50629198
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50399609
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.45890809
38	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.42428369
39	IGF1R_20145208_ChIP-Seq_DFB_Human	1.40843283
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40576733
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40465820
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40465820
43	EZH2_22144423_ChIP-Seq_EOC_Human	1.38596886
44	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.37879719
45	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.36605371
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30553639
47	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.28183807
48	CDX2_22108803_ChIP-Seq_LS180_Human	1.28122131
49	NCOR_22424771_ChIP-Seq_293T_Human	1.26143236
50	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23645546
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22599345
52	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.22431049
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20518350
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20518350
55	STAT3_23295773_ChIP-Seq_U87_Human	1.19158336
56	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18335227
57	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.17756164
58	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17288586
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.16157544
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16066844
61	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.15961673
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.15389454
63	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15003818
64	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.14828746
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14591312
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12157658
67	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11920383
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11819716
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10987823
70	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.10577455
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10143584
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09875525
73	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09666958
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08194745
75	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.08119719
76	AR_25329375_ChIP-Seq_VCAP_Human	1.07916273
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.07564208
78	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05843286
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05256165
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.03741123
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02808208
82	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.02640484
83	SMAD4_21799915_ChIP-Seq_A2780_Human	1.01262317
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00845132
85	TCF4_23295773_ChIP-Seq_U87_Human	1.00581191
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00497038
87	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.99881699
88	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.97895997
89	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97798625
90	ERG_20517297_ChIP-Seq_VCAP_Human	0.97465755
91	GATA3_26560356_Chip-Seq_TH1_Human	0.97074451
92	AR_20517297_ChIP-Seq_VCAP_Human	0.96618067
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95709171
94	GATA3_26560356_Chip-Seq_TH2_Human	0.95000241
95	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.93403226
96	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.93074714
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92748852
98	TAF2_19829295_ChIP-Seq_ESCs_Human	0.92326536
99	REST_21632747_ChIP-Seq_MESCs_Mouse	0.91312945
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90813046

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	3.19215324
2	MP0005367_renal/urinary_system_phenotyp	2.83357267
3	MP0000516_abnormal_urinary_system	2.83357267
4	MP0008995_early_reproductive_senescence	2.78448333
5	MP0005646_abnormal_pituitary_gland	2.78307249
6	MP0003787_abnormal_imprinting	2.62621091
7	MP0003195_calcinosis	2.56872153
8	MP0008875_abnormal_xenobiotic_pharmacok	2.44037527
9	MP0003186_abnormal_redox_activity	2.42478693
10	MP0008872_abnormal_physiological_respon	2.38824401
11	MP0003806_abnormal_nucleotide_metabolis	2.30811709
12	MP0003724_increased_susceptibility_to	2.24190264
13	MP0004885_abnormal_endolymph	2.23026959
14	MP0001968_abnormal_touch/_nociception	2.18679792
15	MP0003878_abnormal_ear_physiology	2.16766214
16	MP0005377_hearing/vestibular/ear_phenot	2.16766214
17	MP0004133_heterotaxia	2.13367971
18	MP0004742_abnormal_vestibular_system	2.13184682
19	MP0001485_abnormal_pinna_reflex	2.09928637
20	MP0000569_abnormal_digit_pigmentation	1.94382122
21	MP0006072_abnormal_retinal_apoptosis	1.94289180
22	MP0002095_abnormal_skin_pigmentation	1.91554780
23	MP0006276_abnormal_autonomic_nervous	1.79535778
24	MP0002837_dystrophic_cardiac_calcinosis	1.77686821
25	MP0005084_abnormal_gallbladder_morpholo	1.76555957
26	MP0005671_abnormal_response_to	1.71638194
27	MP0003786_premature_aging	1.67009315
28	MP0001529_abnormal_vocalization	1.64676161
29	MP0002138_abnormal_hepatobiliary_system	1.62735932
30	MP0004142_abnormal_muscle_tone	1.62651037
31	MP0003183_abnormal_peptide_metabolism	1.60549712
32	MP0001486_abnormal_startle_reflex	1.59241169
33	MP0005551_abnormal_eye_electrophysiolog	1.58059122
34	MP0008877_abnormal_DNA_methylation	1.57795170
35	MP0005174_abnormal_tail_pigmentation	1.56722579
36	MP0001835_abnormal_antigen_presentation	1.56574325
37	MP0004147_increased_porphyrin_level	1.53915821
38	MP0009379_abnormal_foot_pigmentation	1.53819878
39	MP0005360_urolithiasis	1.52934877
40	MP0005253_abnormal_eye_physiology	1.47048627
41	MP0001440_abnormal_grooming_behavior	1.45967749
42	MP0003880_abnormal_central_pattern	1.43537074
43	MP0002938_white_spotting	1.40393192
44	MP0005670_abnormal_white_adipose	1.38630498
45	MP0002277_abnormal_respiratory_mucosa	1.35605013
46	MP0005408_hypopigmentation	1.34065530
47	MP0001984_abnormal_olfaction	1.29281004
48	MP0003890_abnormal_embryonic-extraembry	1.26723381
49	MP0001188_hyperpigmentation	1.25885026
50	MP0003121_genomic_imprinting	1.25368710
51	MP0002102_abnormal_ear_morphology	1.24437901
52	MP0002735_abnormal_chemical_nociception	1.23353820
53	MP0001348_abnormal_lacrimal_gland	1.19425647
54	MP0003136_yellow_coat_color	1.18465447
55	MP0000371_diluted_coat_color	1.18273316
56	MP0005171_absent_coat_pigmentation	1.15305192
57	MP0005075_abnormal_melanosome_morpholog	1.11039292
58	MP0001502_abnormal_circadian_rhythm	1.10743871
59	MP0001661_extended_life_span	1.07918840
60	MP0009745_abnormal_behavioral_response	1.06236000
61	MP0001764_abnormal_homeostasis	1.03947328
62	MP0001800_abnormal_humoral_immune	1.03935063
63	MP0000026_abnormal_inner_ear	1.02468774
64	MP0009765_abnormal_xenobiotic_induced	1.01373944
65	MP0001873_stomach_inflammation	0.99439434
66	MP0005645_abnormal_hypothalamus_physiol	0.99122221
67	MP0002272_abnormal_nervous_system	0.98371917
68	MP0005636_abnormal_mineral_homeostasis	0.94151092
69	MP0003567_abnormal_fetal_cardiomyocyte	0.90074619
70	MP0006292_abnormal_olfactory_placode	0.88327898
71	MP0005423_abnormal_somatic_nervous	0.87900583
72	MP0000049_abnormal_middle_ear	0.87759073
73	MP0002928_abnormal_bile_duct	0.87421780
74	MP0003646_muscle_fatigue	0.83385699
75	MP0008058_abnormal_DNA_repair	0.82920981
76	MP0000631_abnormal_neuroendocrine_gland	0.82386489
77	MP0002234_abnormal_pharynx_morphology	0.82332380
78	MP0000534_abnormal_ureter_morphology	0.79203785
79	MP0005195_abnormal_posterior_eye	0.77162833
80	MP0003937_abnormal_limbs/digits/tail_de	0.76417548
81	MP0003252_abnormal_bile_duct	0.75560628
82	MP0001905_abnormal_dopamine_level	0.75398163
83	MP0000015_abnormal_ear_pigmentation	0.74873463
84	MP0003718_maternal_effect	0.74869239
85	MP0002572_abnormal_emotion/affect_behav	0.74603229
86	MP0001986_abnormal_taste_sensitivity	0.73758479
87	MP0004043_abnormal_pH_regulation	0.71926471
88	MP0001963_abnormal_hearing_physiology	0.71700370
89	MP0001324_abnormal_eye_pigmentation	0.71507679
90	MP0001501_abnormal_sleep_pattern	0.70458954
91	MP0001970_abnormal_pain_threshold	0.70300540
92	MP0003122_maternal_imprinting	0.70198343
93	MP0002733_abnormal_thermal_nociception	0.70098097
94	MP0002734_abnormal_mechanical_nocicepti	0.69330523
95	MP0002229_neurodegeneration	0.69067343
96	MP0001919_abnormal_reproductive_system	0.65861593
97	MP0005584_abnormal_enzyme/coenzyme_acti	0.65024726
98	MP0002009_preneoplasia	0.64470510
99	MP0002006_tumorigenesis	0.63841997
100	MP0002752_abnormal_somatic_nervous	0.62854971

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	7.12882689
2	Hyperalaninemia (HP:0003348)	7.12882689
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.12882689
4	Constricted visual fields (HP:0001133)	5.28019982
5	Congenital sensorineural hearing impairment (HP:0008527)	4.92186000
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.82310630
7	Elevated erythrocyte sedimentation rate (HP:0003565)	3.25047013
8	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.21279834
9	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.19666106
10	Mitochondrial inheritance (HP:0001427)	3.03812307
11	Hepatocellular necrosis (HP:0001404)	2.94000136
12	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.91706481
13	Molar tooth sign on MRI (HP:0002419)	2.91211313
14	Abnormality of midbrain morphology (HP:0002418)	2.91211313
15	Patchy hypopigmentation of hair (HP:0011365)	2.88675599
16	Acute necrotizing encephalopathy (HP:0006965)	2.87752808
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.86154698
18	Abnormal umbilical cord blood vessels (HP:0011403)	2.85790571
19	Single umbilical artery (HP:0001195)	2.85790571
20	Abnormality of the fetal cardiovascular system (HP:0010948)	2.85790571
21	Increased hepatocellular lipid droplets (HP:0006565)	2.73067699
22	Abnormality of serum amino acid levels (HP:0003112)	2.71248609
23	Increased serum lactate (HP:0002151)	2.71025383
24	Increased CSF lactate (HP:0002490)	2.69468980
25	Progressive macrocephaly (HP:0004481)	2.65976898
26	True hermaphroditism (HP:0010459)	2.65258630
27	Acute encephalopathy (HP:0006846)	2.59980393
28	White forelock (HP:0002211)	2.47311152
29	Congenital, generalized hypertrichosis (HP:0004540)	2.43138239
30	Attenuation of retinal blood vessels (HP:0007843)	2.42533830
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.41479325
32	Lipid accumulation in hepatocytes (HP:0006561)	2.40945351
33	Birth length less than 3rd percentile (HP:0003561)	2.40695102
34	Hepatic necrosis (HP:0002605)	2.36932152
35	Lactic acidosis (HP:0003128)	2.35159888
36	Nephrogenic diabetes insipidus (HP:0009806)	2.25183420
37	Exertional dyspnea (HP:0002875)	2.24233660
38	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.20827784
39	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.20827784
40	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.19800445
41	Stomatitis (HP:0010280)	2.18782677
42	Chronic hepatic failure (HP:0100626)	2.15124036
43	Renal Fanconi syndrome (HP:0001994)	2.13889535
44	Abolished electroretinogram (ERG) (HP:0000550)	2.13044216
45	Tetany (HP:0001281)	2.12956187
46	Pancreatic cysts (HP:0001737)	2.10999898
47	Progressive cerebellar ataxia (HP:0002073)	2.10286322
48	3-Methylglutaconic aciduria (HP:0003535)	2.09001955
49	Nephronophthisis (HP:0000090)	2.07025133
50	Abnormality of homocysteine metabolism (HP:0010919)	2.06330935
51	Homocystinuria (HP:0002156)	2.06330935
52	Large for gestational age (HP:0001520)	2.05289823
53	Hypothermia (HP:0002045)	2.00881947
54	Pancreatic fibrosis (HP:0100732)	2.00299155
55	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.00107105
56	Medial flaring of the eyebrow (HP:0010747)	1.98820821
57	Genetic anticipation (HP:0003743)	1.96253213
58	Spontaneous hematomas (HP:0007420)	1.95960110
59	Anorexia (HP:0002039)	1.95859730
60	Congenital primary aphakia (HP:0007707)	1.92904665
61	Gait imbalance (HP:0002141)	1.91657649
62	Cerebral edema (HP:0002181)	1.90917260
63	Hypomagnesemia (HP:0002917)	1.90530319
64	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.90492255
65	Generalized aminoaciduria (HP:0002909)	1.89556224
66	Hypoplasia of the thymus (HP:0000778)	1.89413654
67	Reticulocytopenia (HP:0001896)	1.88466984
68	Short tibia (HP:0005736)	1.85163076
69	Failure to thrive in infancy (HP:0001531)	1.84119972
70	Anencephaly (HP:0002323)	1.83665210
71	Poor speech (HP:0002465)	1.83283085
72	Esophageal varix (HP:0002040)	1.82301812
73	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.82169313
74	Optic disc pallor (HP:0000543)	1.81839636
75	Congenital malformation of the right heart (HP:0011723)	1.78616743
76	Double outlet right ventricle (HP:0001719)	1.78616743
77	Bony spicule pigmentary retinopathy (HP:0007737)	1.75029908
78	Abnormal respiratory epithelium morphology (HP:0012253)	1.74285805
79	Abnormal respiratory motile cilium morphology (HP:0005938)	1.74285805
80	Abnormal hemoglobin (HP:0011902)	1.73565443
81	Duplicated collecting system (HP:0000081)	1.73044855
82	Type II lissencephaly (HP:0007260)	1.72636765
83	Conjugated hyperbilirubinemia (HP:0002908)	1.72002009
84	Oligomenorrhea (HP:0000876)	1.71020980
85	Action tremor (HP:0002345)	1.70412488
86	Leukodystrophy (HP:0002415)	1.69924790
87	Pulmonary embolism (HP:0002204)	1.69041400
88	Maternal diabetes (HP:0009800)	1.67348344
89	Type I transferrin isoform profile (HP:0003642)	1.66710500
90	Respiratory failure (HP:0002878)	1.66536552
91	Abnormality of the renal collecting system (HP:0004742)	1.66403443
92	Hypoalphalipoproteinemia (HP:0003233)	1.65013027
93	Poor coordination (HP:0002370)	1.64267200
94	Abnormality of the renal medulla (HP:0100957)	1.62608082
95	Increased intramyocellular lipid droplets (HP:0012240)	1.62522320
96	Microcytic anemia (HP:0001935)	1.62334544
97	Methylmalonic acidemia (HP:0002912)	1.62115498
98	Chorioretinal atrophy (HP:0000533)	1.61990038
99	Glycosuria (HP:0003076)	1.61848057
100	Abnormality of urine glucose concentration (HP:0011016)	1.61848057

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	2.99120179
2	MAP4K2	2.78466241
3	FRK	2.58480603
4	ACVR1B	2.33007685
5	WNK3	2.32856416
6	MAP2K3	2.28458798
7	MAPK15	2.25515080
8	NME1	2.09459451
9	OXSR1	1.98202271
10	TLK1	1.90440182
11	MAP3K12	1.90034964
12	TIE1	1.85143476
13	TRIM28	1.76709957
14	NTRK2	1.76369024
15	TXK	1.68948062
16	TEC	1.58893133
17	MAPKAPK5	1.57674022
18	NTRK3	1.57368753
19	GRK1	1.55128167
20	MAP4K1	1.54406058
21	ADRBK2	1.48481639
22	MAPK13	1.44049275
23	STK16	1.41895693
24	NUAK1	1.41728360
25	PBK	1.38055357
26	PIK3CG	1.35744759
27	PIK3CA	1.35133192
28	CDK19	1.34698363
29	TAOK3	1.33831520
30	FGR	1.31312194
31	BCKDK	1.29892602
32	ERBB3	1.23863117
33	PDK2	1.20260668
34	TRPM7	1.11843277
35	RPS6KB2	1.11777307
36	ITK	1.11233025
37	TAF1	1.10328135
38	MAP3K4	1.08569555
39	IRAK4	1.07252920
40	TNIK	1.06473133
41	IRAK2	1.00400919
42	ADRBK1	0.97443089
43	DYRK2	0.97412994
44	MAP3K6	0.96922223
45	PASK	0.96571509
46	EPHB2	0.96216243
47	VRK1	0.95382516
48	WNK4	0.94833362
49	STK39	0.92810353
50	BMPR1B	0.92117365
51	ZAK	0.91379045
52	MAP3K3	0.91169879
53	CDK9	0.86787544
54	MKNK2	0.85545115
55	CCNB1	0.85010559
56	BMPR2	0.84407686
57	PNCK	0.83158862
58	MAP2K4	0.82756166
59	CASK	0.81981567
60	JAK3	0.81739448
61	GRK6	0.81139229
62	SRPK1	0.75405104
63	SYK	0.74672700
64	IKBKE	0.73242396
65	IKBKB	0.72040489
66	SGK223	0.71246309
67	SGK494	0.71246309
68	DYRK1A	0.68988142
69	VRK2	0.67904099
70	MARK3	0.65472500
71	TGFBR1	0.64098031
72	SIK3	0.61525339
73	EIF2AK3	0.58129191
74	PRKCE	0.56377887
75	MINK1	0.52996741
76	PRKCQ	0.52169464
77	CSNK1G2	0.50714384
78	NEK6	0.50472282
79	GRK7	0.50259281
80	MAP2K6	0.50111147
81	EGFR	0.49927283
82	OBSCN	0.48854620
83	MATK	0.47813542
84	INSRR	0.45625775
85	SIK2	0.45031071
86	RPS6KA5	0.42349200
87	PRKCI	0.40346868
88	CAMK2A	0.40037193
89	CSK	0.39765191
90	CDK3	0.39527822
91	LYN	0.38995452
92	MAP2K7	0.38969214
93	LCK	0.38960915
94	PLK3	0.38908211
95	CAMK1	0.38407674
96	PRKACA	0.38068572
97	FGFR3	0.37792160
98	ILK	0.37766230
99	PAK3	0.37385233
100	PLK2	0.37192858

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.91857385
2	Asthma_Homo sapiens_hsa05310	3.45765316
3	Protein export_Homo sapiens_hsa03060	3.14875662
4	Parkinsons disease_Homo sapiens_hsa05012	2.99776275
5	Proteasome_Homo sapiens_hsa03050	2.90594438
6	One carbon pool by folate_Homo sapiens_hsa00670	2.67522407
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.47992001
8	Sulfur metabolism_Homo sapiens_hsa00920	2.38939257
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.37675909
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.33418664
11	Allograft rejection_Homo sapiens_hsa05330	2.28393844
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.22736346
13	Huntingtons disease_Homo sapiens_hsa05016	2.01663622
14	Ribosome_Homo sapiens_hsa03010	1.97093511
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.94086455
16	Alzheimers disease_Homo sapiens_hsa05010	1.94072971
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.90528358
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.90490908
19	RNA polymerase_Homo sapiens_hsa03020	1.83771135
20	Nicotine addiction_Homo sapiens_hsa05033	1.79562543
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.70982584
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.70712000
23	Phototransduction_Homo sapiens_hsa04744	1.55952696
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.52701433
25	RNA degradation_Homo sapiens_hsa03018	1.47666487
26	Spliceosome_Homo sapiens_hsa03040	1.44919226
27	Morphine addiction_Homo sapiens_hsa05032	1.41916896
28	Graft-versus-host disease_Homo sapiens_hsa05332	1.35484671
29	Propanoate metabolism_Homo sapiens_hsa00640	1.30181455
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.28243030
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.19736340
32	Sulfur relay system_Homo sapiens_hsa04122	1.19546688
33	Butanoate metabolism_Homo sapiens_hsa00650	1.19382359
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.14651045
35	GABAergic synapse_Homo sapiens_hsa04727	1.13960702
36	Peroxisome_Homo sapiens_hsa04146	1.12706438
37	Basal transcription factors_Homo sapiens_hsa03022	1.09373053
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08902987
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07661396
40	Taste transduction_Homo sapiens_hsa04742	1.07057830
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.06399130
42	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.05005229
43	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.04949517
44	Serotonergic synapse_Homo sapiens_hsa04726	1.01339901
45	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.01338844
46	Rheumatoid arthritis_Homo sapiens_hsa05323	0.99621938
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.97765368
48	Homologous recombination_Homo sapiens_hsa03440	0.95899437
49	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.94812543
50	Caffeine metabolism_Homo sapiens_hsa00232	0.92149741
51	Antigen processing and presentation_Homo sapiens_hsa04612	0.90642410
52	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.90626425
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90231393
54	Regulation of autophagy_Homo sapiens_hsa04140	0.88298918
55	Olfactory transduction_Homo sapiens_hsa04740	0.84594798
56	Mineral absorption_Homo sapiens_hsa04978	0.83909774
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83330174
58	Purine metabolism_Homo sapiens_hsa00230	0.81646145
59	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.80417535
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80158982
61	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.78973099
62	Retinol metabolism_Homo sapiens_hsa00830	0.76245838
63	Leishmaniasis_Homo sapiens_hsa05140	0.75039742
64	RNA transport_Homo sapiens_hsa03013	0.73181803
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67415158
66	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.65512931
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64628010
68	Metabolic pathways_Homo sapiens_hsa01100	0.63492380
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.63064700
70	Dopaminergic synapse_Homo sapiens_hsa04728	0.61607656
71	Linoleic acid metabolism_Homo sapiens_hsa00591	0.59741162
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.55884905
73	Primary immunodeficiency_Homo sapiens_hsa05340	0.55692368
74	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55146379
75	Circadian entrainment_Homo sapiens_hsa04713	0.54153076
76	Legionellosis_Homo sapiens_hsa05134	0.48266426
77	Fatty acid elongation_Homo sapiens_hsa00062	0.46343441
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45417818
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44875874
80	Mismatch repair_Homo sapiens_hsa03430	0.43924423
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40905387
82	Glutathione metabolism_Homo sapiens_hsa00480	0.40511626
83	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.40509520
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.36540548
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.33851303
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32656007
87	Cholinergic synapse_Homo sapiens_hsa04725	0.32514443
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30784899
89	Arginine biosynthesis_Homo sapiens_hsa00220	0.30738804
90	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.29807572
91	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.29569728
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.29546337
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.27489034
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.27412108
95	Folate biosynthesis_Homo sapiens_hsa00790	0.27016055
96	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.23113482
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.22939058
98	Ether lipid metabolism_Homo sapiens_hsa00565	0.22176579
99	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.21981783
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.20991558

RWDD4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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