RXFP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound catabolic process (GO:0019336)7.75003521
2behavioral response to nicotine (GO:0035095)6.89296794
3prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.46454971
4vocalization behavior (GO:0071625)5.30775941
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.17776521
6regulation of calcineurin-NFAT signaling cascade (GO:0070884)5.14512825
7lung lobe morphogenesis (GO:0060463)5.10854005
8regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.70470021
9L-amino acid import (GO:0043092)4.68971662
10positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.59698942
11sympathetic nervous system development (GO:0048485)4.58424904
12neuron cell-cell adhesion (GO:0007158)4.54806519
13behavioral response to ethanol (GO:0048149)4.49614160
14positive regulation of cardiac muscle hypertrophy (GO:0010613)4.44984425
15positive regulation of muscle hypertrophy (GO:0014742)4.44984425
16synaptic vesicle exocytosis (GO:0016079)4.41568765
17catecholamine transport (GO:0051937)4.36263526
18maternal behavior (GO:0042711)4.25131795
19dopamine biosynthetic process (GO:0042416)4.20724939
20prostate gland growth (GO:0060736)4.20451835
21negative regulation of neurotransmitter transport (GO:0051589)4.19988130
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.12746838
23protein localization to synapse (GO:0035418)4.07671894
24dopamine metabolic process (GO:0042417)3.98968890
25negative regulation of synaptic transmission, GABAergic (GO:0032229)3.98524142
26neurotransmitter secretion (GO:0007269)3.94211746
27catecholamine biosynthetic process (GO:0042423)3.91816420
28catechol-containing compound biosynthetic process (GO:0009713)3.91816420
29regulation of glutamate receptor signaling pathway (GO:1900449)3.89068649
30kynurenine metabolic process (GO:0070189)3.82640682
31interleukin-6-mediated signaling pathway (GO:0070102)3.80617405
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.77209067
33glutamate secretion (GO:0014047)3.73445416
34neurotransmitter catabolic process (GO:0042135)3.69565801
35regulation of female receptivity (GO:0045924)3.69132681
36parental behavior (GO:0060746)3.68555837
37indole-containing compound catabolic process (GO:0042436)3.68497795
38indolalkylamine catabolic process (GO:0046218)3.68497795
39tryptophan catabolic process (GO:0006569)3.68497795
40insulin-like growth factor receptor signaling pathway (GO:0048009)3.64860863
41positive regulation of protein import into nucleus, translocation (GO:0033160)3.63744547
42regulation of synaptic vesicle exocytosis (GO:2000300)3.62882082
43C4-dicarboxylate transport (GO:0015740)3.53425638
44locomotory exploration behavior (GO:0035641)3.53195189
45response to pain (GO:0048265)3.48312855
46multicellular organismal reproductive behavior (GO:0033057)3.46675493
47neuron-neuron synaptic transmission (GO:0007270)3.46377481
48neurotransmitter biosynthetic process (GO:0042136)3.43282897
49presynaptic membrane assembly (GO:0097105)3.42945398
50lung vasculature development (GO:0060426)3.42366419
51synaptic transmission, cholinergic (GO:0007271)3.42030482
52regulation of synapse maturation (GO:0090128)3.41228360
53interleukin-1-mediated signaling pathway (GO:0070498)3.41037398
54regulation of neurotransmitter secretion (GO:0046928)3.40818595
55detection of calcium ion (GO:0005513)3.40091072
56serotonin metabolic process (GO:0042428)3.37503419
57neuromuscular synaptic transmission (GO:0007274)3.35206389
58tryptophan metabolic process (GO:0006568)3.35159730
59neurotransmitter transport (GO:0006836)3.35143964
60positive regulation of synapse maturation (GO:0090129)3.32544538
61regulation of pigment cell differentiation (GO:0050932)3.31999105
62positive regulation of potassium ion transmembrane transport (GO:1901381)3.31784924
633-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.30375305
64purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.30375305
65multi-organism reproductive behavior (GO:0044705)3.30065482
66regulation of respiratory gaseous exchange (GO:0043576)3.28895123
67synaptic transmission, dopaminergic (GO:0001963)3.28751927
68exploration behavior (GO:0035640)3.28130435
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27937756
70positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26012452
71prenylation (GO:0097354)3.25762580
72protein prenylation (GO:0018342)3.25762580
73norepinephrine metabolic process (GO:0042415)3.24415987
74amino acid import (GO:0043090)3.23465307
75neurotransmitter-gated ion channel clustering (GO:0072578)3.22283754
76positive regulation of glycolytic process (GO:0045821)3.21706667
77regulation of voltage-gated calcium channel activity (GO:1901385)3.20913362
78ionotropic glutamate receptor signaling pathway (GO:0035235)3.19533845
79response to amphetamine (GO:0001975)3.18563790
80dopamine transport (GO:0015872)3.18333190
81regulation of neurotransmitter transport (GO:0051588)3.18307259
82cardiac chamber formation (GO:0003207)3.16491321
83proline transport (GO:0015824)3.16446914
84synaptic vesicle docking involved in exocytosis (GO:0016081)3.16078105
85regulation of synaptic vesicle transport (GO:1902803)3.15791224
86exocrine pancreas development (GO:0031017)3.15601435
87startle response (GO:0001964)3.13763249
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.09898789
89regulation of vesicle fusion (GO:0031338)3.09294685
90reproductive behavior (GO:0019098)3.08888970
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08338824
92positive regulation of neurotransmitter transport (GO:0051590)3.07179337
93glutamate receptor signaling pathway (GO:0007215)3.07003188
94neuronal action potential propagation (GO:0019227)3.06369098
95presynaptic membrane organization (GO:0097090)3.05476580
96branching involved in prostate gland morphogenesis (GO:0060442)3.05039140
97positive regulation of vesicle fusion (GO:0031340)3.04511572
98regulation of excitatory postsynaptic membrane potential (GO:0060079)3.04458474
99growth hormone receptor signaling pathway (GO:0060396)3.04169535
100sleep (GO:0030431)3.04049011
101postsynaptic membrane organization (GO:0001941)3.01853457
102gamma-aminobutyric acid signaling pathway (GO:0007214)2.98787796
103regulation of synaptic transmission, glutamatergic (GO:0051966)2.98710460
104regulation of neurotransmitter levels (GO:0001505)2.97215231
105female mating behavior (GO:0060180)2.97149009
106sodium ion export (GO:0071436)2.96966411
107positive regulation of smooth muscle cell migration (GO:0014911)2.96788355
108gamma-aminobutyric acid transport (GO:0015812)2.96575996
109central nervous system myelination (GO:0022010)2.95587758
110axon ensheathment in central nervous system (GO:0032291)2.95587758
111acidic amino acid transport (GO:0015800)2.94865796
112primary amino compound metabolic process (GO:1901160)2.94660467
113regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.93903587
114regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.93903587
115cellular potassium ion homeostasis (GO:0030007)2.93710915
116indole-containing compound metabolic process (GO:0042430)2.93276106
117cerebellar Purkinje cell differentiation (GO:0021702)2.93171655
118regulation of cardiac muscle hypertrophy (GO:0010611)2.92769640
119long-term memory (GO:0007616)2.92245404
120synaptic transmission, glutamatergic (GO:0035249)2.92173398
121synaptic vesicle endocytosis (GO:0048488)2.90267360
122regulation of long-term neuronal synaptic plasticity (GO:0048169)2.89677825
123regulation of synapse structural plasticity (GO:0051823)2.88207544
124synapse assembly (GO:0007416)2.88170303
125response to cocaine (GO:0042220)2.87709384
126mating behavior (GO:0007617)2.86740076
127regulation of neuronal synaptic plasticity (GO:0048168)2.85273248
128regulation of postsynaptic membrane potential (GO:0060078)2.85034813
129mesonephros development (GO:0001823)2.84877456
130regulation of muscle adaptation (GO:0043502)2.83932238
131ovulation from ovarian follicle (GO:0001542)2.83573566
132catecholamine metabolic process (GO:0006584)2.83052972
133catechol-containing compound metabolic process (GO:0009712)2.83052972
134glycoprotein catabolic process (GO:0006516)2.82902241
135positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.82680155
136vesicle docking involved in exocytosis (GO:0006904)2.81552438
137synaptic vesicle maturation (GO:0016188)2.81272507
138response to histamine (GO:0034776)2.79737343
139regulation of muscle hypertrophy (GO:0014743)2.78204371
140L-glutamate transport (GO:0015813)2.78115146
141negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78007379
142cellular response to growth hormone stimulus (GO:0071378)2.77952220
143transmission of nerve impulse (GO:0019226)2.77586745
144regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.77561562
145positive regulation of neurotransmitter secretion (GO:0001956)2.76567218
146regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74780175
147long-term synaptic potentiation (GO:0060291)2.73934827
148neuron recognition (GO:0008038)2.72456436
149behavioral response to cocaine (GO:0048148)2.72024072
150positive regulation of dendritic spine development (GO:0060999)2.71822423
151asymmetric protein localization (GO:0008105)2.71771193
152monoamine transport (GO:0015844)2.70957841
153G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.70701673
154cell migration in hindbrain (GO:0021535)2.70569074
155adult behavior (GO:0030534)2.70351792
156membrane depolarization during action potential (GO:0086010)2.70093170
157regulation of respiratory system process (GO:0044065)2.69656499
158cellular response to ammonium ion (GO:0071242)2.69578745
159regulation of establishment or maintenance of cell polarity (GO:0032878)2.68345670
160negative regulation of dendrite morphogenesis (GO:0050774)2.68180936
161cellular response to reactive nitrogen species (GO:1902170)2.64591897
162indolalkylamine metabolic process (GO:0006586)2.62713056
163retinal cone cell development (GO:0046549)2.60777125
164vesicle docking (GO:0048278)2.56877633
165negative regulation of metanephros development (GO:0072217)2.55221625
166aromatic amino acid family catabolic process (GO:0009074)2.54252864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.45823174
2GBX2_23144817_ChIP-Seq_PC3_Human3.89076816
3GATA1_22025678_ChIP-Seq_K562_Human3.40263018
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00023599
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.91941750
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89561095
7TAF15_26573619_Chip-Seq_HEK293_Human2.78657373
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71179882
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64508995
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.55162513
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49044299
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44737648
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42651345
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.41059985
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37250795
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37250795
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.35717425
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28133347
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.22211450
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13720608
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10339869
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06715180
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00854896
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96697453
25SMAD4_21799915_ChIP-Seq_A2780_Human1.95475958
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94778404
27* P300_19829295_ChIP-Seq_ESCs_Human1.94095970
28FUS_26573619_Chip-Seq_HEK293_Human1.92707823
29REST_21632747_ChIP-Seq_MESCs_Mouse1.91739123
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91505376
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91475745
32AR_21572438_ChIP-Seq_LNCaP_Human1.87106564
33NR3C1_23031785_ChIP-Seq_PC12_Mouse1.85409364
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84740163
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83550229
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82845498
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76845462
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.76081010
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74817958
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74484331
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.73651878
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.73295410
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67813168
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63333701
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.62657112
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62246228
47* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61574555
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59075502
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58412698
50DROSHA_22980978_ChIP-Seq_HELA_Human1.58059226
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.56940287
52AR_25329375_ChIP-Seq_VCAP_Human1.56440853
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.55630883
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52718437
55* SMAD3_21741376_ChIP-Seq_EPCs_Human1.50755313
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48592720
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.43745741
58IGF1R_20145208_ChIP-Seq_DFB_Human1.43262538
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42804718
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41533048
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41515112
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41515112
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.40837205
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40772616
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39744325
66RNF2_27304074_Chip-Seq_NSC_Mouse1.39704935
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38633257
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37777675
69BCAT_22108803_ChIP-Seq_LS180_Human1.37555448
70TP53_18474530_ChIP-ChIP_U2OS_Human1.36000407
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.34775581
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32903147
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.32676819
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.32539690
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32024410
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30470507
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28922442
78ER_23166858_ChIP-Seq_MCF-7_Human1.27517397
79STAT3_23295773_ChIP-Seq_U87_Human1.26557034
80* TCF4_23295773_ChIP-Seq_U87_Human1.25121070
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23606476
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.23149802
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22941330
84* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22761979
85VDR_22108803_ChIP-Seq_LS180_Human1.21981528
86HTT_18923047_ChIP-ChIP_STHdh_Human1.21879451
87JUN_21703547_ChIP-Seq_K562_Human1.20788139
88* RUNX2_22187159_ChIP-Seq_PCA_Human1.19621049
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18698827
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18341485
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18032776
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17749636
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.17344880
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16538504
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16276727
96* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13822064
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.13475430
98LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13078706
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.12947048
100P53_22387025_ChIP-Seq_ESCs_Mouse1.12704993
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12035511
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10582510
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10449188
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09788615
105RARB_27405468_Chip-Seq_BRAIN_Mouse1.09127800
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08823885
107CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08613253
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08406867
109ZNF274_21170338_ChIP-Seq_K562_Hela1.08391832
110TCF4_22108803_ChIP-Seq_LS180_Human1.08164390
111SCL_19346495_ChIP-Seq_HPC-7_Human1.06498762
112ESR1_21235772_ChIP-Seq_MCF-7_Human1.06116104
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05115654
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.04122114
115EWS_26573619_Chip-Seq_HEK293_Human1.03603036
116* SOX2_18555785_Chip-Seq_ESCs_Mouse1.03477190
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03239065
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.02715830
119CBP_20019798_ChIP-Seq_JUKART_Human1.02582025
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02582025
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02357399
122AHR_22903824_ChIP-Seq_MCF-7_Human1.02143038
123* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01511632
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01173996
125* AR_19668381_ChIP-Seq_PC3_Human1.00600814
126WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00307446
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00258628
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98778708
129KDM2B_26808549_Chip-Seq_REH_Human0.98400620
130TP53_16413492_ChIP-PET_HCT116_Human0.98143672
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.96003934

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.21720124
2MP0008004_abnormal_stomach_pH4.39892141
3MP0010386_abnormal_urinary_bladder4.29513688
4MP0004859_abnormal_synaptic_plasticity3.49647747
5MP0009745_abnormal_behavioral_response3.31260541
6MP0002638_abnormal_pupillary_reflex3.15164541
7MP0003635_abnormal_synaptic_transmissio3.05345434
8MP0001501_abnormal_sleep_pattern2.75313432
9MP0001905_abnormal_dopamine_level2.71482247
10MP0009046_muscle_twitch2.60406758
11MP0002064_seizures2.57687684
12MP0002572_abnormal_emotion/affect_behav2.54111115
13MP0002063_abnormal_learning/memory/cond2.53205405
14MP0002734_abnormal_mechanical_nocicepti2.51667014
15MP0003880_abnormal_central_pattern2.50033585
16MP0006276_abnormal_autonomic_nervous2.49014662
17MP0004270_analgesia2.47255659
18MP0001188_hyperpigmentation2.45901727
19MP0005646_abnormal_pituitary_gland2.41892809
20MP0002735_abnormal_chemical_nociception2.40083958
21MP0001968_abnormal_touch/_nociception2.20704343
22MP0001440_abnormal_grooming_behavior2.19427406
23MP0002272_abnormal_nervous_system2.10915549
24MP0001529_abnormal_vocalization2.00736291
25MP0001970_abnormal_pain_threshold1.98269880
26MP0003724_increased_susceptibility_to1.92526277
27MP0004924_abnormal_behavior1.90984886
28MP0005386_behavior/neurological_phenoty1.90984886
29MP0006054_spinal_hemorrhage1.90357770
30MP0003941_abnormal_skin_development1.89115251
31MP0002733_abnormal_thermal_nociception1.85990178
32MP0002067_abnormal_sensory_capabilities1.75527475
33MP0001486_abnormal_startle_reflex1.74821855
34MP0002736_abnormal_nociception_after1.74523116
35MP0003787_abnormal_imprinting1.71586840
36MP0002837_dystrophic_cardiac_calcinosis1.69867097
37MP0000383_abnormal_hair_follicle1.68209922
38MP0005171_absent_coat_pigmentation1.65662449
39MP0003122_maternal_imprinting1.64874554
40MP0000538_abnormal_urinary_bladder1.63407099
41MP0002557_abnormal_social/conspecific_i1.59595534
42MP0002184_abnormal_innervation1.59424967
43MP0001542_abnormal_bone_strength1.51089531
44MP0001984_abnormal_olfaction1.51060999
45MP0003300_gastrointestinal_ulcer1.50180032
46MP0008569_lethality_at_weaning1.50004671
47MP0009780_abnormal_chondrocyte_physiolo1.43240526
48MP0004858_abnormal_nervous_system1.42272754
49MP0000920_abnormal_myelination1.41460438
50MP0008872_abnormal_physiological_respon1.40887593
51MP0003638_abnormal_response/metabolism_1.36895575
52MP0002876_abnormal_thyroid_physiology1.35489552
53MP0003690_abnormal_glial_cell1.34381502
54MP0005423_abnormal_somatic_nervous1.34136081
55MP0005409_darkened_coat_color1.33031980
56MP0004130_abnormal_muscle_cell1.30801605
57MP0004085_abnormal_heartbeat1.29684574
58MP0005645_abnormal_hypothalamus_physiol1.27218535
59MP0003938_abnormal_ear_development1.26920737
60MP0000604_amyloidosis1.26627544
61MP0000778_abnormal_nervous_system1.24876078
62MP0006292_abnormal_olfactory_placode1.23122868
63MP0002138_abnormal_hepatobiliary_system1.20880231
64MP0002163_abnormal_gland_morphology1.17905056
65MP0000372_irregular_coat_pigmentation1.16569310
66MP0004484_altered_response_of1.16319555
67MP0003183_abnormal_peptide_metabolism1.16022656
68MP0003879_abnormal_hair_cell1.14533671
69MP0002751_abnormal_autonomic_nervous1.13888754
70MP0000013_abnormal_adipose_tissue1.10227342
71MP0001502_abnormal_circadian_rhythm1.09000223
72MP0000569_abnormal_digit_pigmentation1.07875523
73MP0005503_abnormal_tendon_morphology1.06582612
74MP0004215_abnormal_myocardial_fiber1.04320192
75MP0000465_gastrointestinal_hemorrhage1.03567100
76MP0002066_abnormal_motor_capabilities/c0.99936167
77MP0001177_atelectasis0.98723989
78MP0002127_abnormal_cardiovascular_syste0.97688875
79MP0002909_abnormal_adrenal_gland0.97465361
80MP0003631_nervous_system_phenotype0.97423215
81MP0004147_increased_porphyrin_level0.95883807
82MP0001919_abnormal_reproductive_system0.95853170
83MP0000230_abnormal_systemic_arterial0.95458708
84MP0004811_abnormal_neuron_physiology0.94999486
85MP0005379_endocrine/exocrine_gland_phen0.94436567
86MP0003633_abnormal_nervous_system0.93967755
87* MP0005389_reproductive_system_phenotype0.93470247
88MP0002229_neurodegeneration0.90431624
89MP0000015_abnormal_ear_pigmentation0.89795146
90MP0002882_abnormal_neuron_morphology0.88718157
91MP0003075_altered_response_to0.88562357
92MP0000751_myopathy0.87703306
93MP0001835_abnormal_antigen_presentation0.87301886
94MP0010678_abnormal_skin_adnexa0.86071167
95MP0005620_abnormal_muscle_contractility0.85568230
96MP0001851_eye_inflammation0.83810234
97* MP0002160_abnormal_reproductive_system0.82064291
98MP0002972_abnormal_cardiac_muscle0.81522022
99MP0005551_abnormal_eye_electrophysiolog0.81481733
100MP0003329_amyloid_beta_deposits0.80499847
101MP0003436_decreased_susceptibility_to0.79923241
102MP0008874_decreased_physiological_sensi0.79689445
103MP0000955_abnormal_spinal_cord0.79126197
104MP0003632_abnormal_nervous_system0.77889563
105MP0001765_abnormal_ion_homeostasis0.77386832
106MP0001986_abnormal_taste_sensitivity0.75927745
107MP0001664_abnormal_digestion0.74678202
108MP0004883_abnormal_blood_vessel0.73522153
109MP0004742_abnormal_vestibular_system0.73394421
110MP0005394_taste/olfaction_phenotype0.72971039
111MP0005499_abnormal_olfactory_system0.72971039
112MP0002102_abnormal_ear_morphology0.72127199
113MP0002069_abnormal_eating/drinking_beha0.71717191
114MP0000681_abnormal_thyroid_gland0.70494623
115MP0001963_abnormal_hearing_physiology0.70146895
116MP0005535_abnormal_body_temperature0.69848856
117MP0003121_genomic_imprinting0.68674734
118MP0001270_distended_abdomen0.68383626
119MP0000049_abnormal_middle_ear0.68272840
120MP0002108_abnormal_muscle_morphology0.68241149
121MP0000639_abnormal_adrenal_gland0.67491757
122MP0005595_abnormal_vascular_smooth0.66928654
123MP0001533_abnormal_skeleton_physiology0.66810698
124MP0000631_abnormal_neuroendocrine_gland0.66541273
125MP0008438_abnormal_cutaneous_collagen0.66424691
126MP0006138_congestive_heart_failure0.66349198
127MP0000516_abnormal_urinary_system0.65807464
128MP0005367_renal/urinary_system_phenotyp0.65807464
129MP0002152_abnormal_brain_morphology0.65473863
130MP0002254_reproductive_system_inflammat0.64538495
131MP0002090_abnormal_vision0.62847214
132MP0005197_abnormal_uvea_morphology0.62071142
133MP0004885_abnormal_endolymph0.61622072
134MP0004142_abnormal_muscle_tone0.61370389
135MP0003045_fibrosis0.60732260
136MP0003279_aneurysm0.60726109
137MP0000427_abnormal_hair_cycle0.60093239
138MP0005508_abnormal_skeleton_morphology0.59988769
139MP0003634_abnormal_glial_cell0.59354817
140MP0001958_emphysema0.57217470
141MP0005390_skeleton_phenotype0.51642395
142MP0002928_abnormal_bile_duct0.51506810

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)8.37489394
2Focal motor seizures (HP:0011153)7.90907318
3Febrile seizures (HP:0002373)5.88815860
4Neonatal short-limb short stature (HP:0008921)5.16324521
5Atonic seizures (HP:0010819)4.85145176
6Myokymia (HP:0002411)4.70661390
7Focal seizures (HP:0007359)4.69692023
8Hyperventilation (HP:0002883)4.68131673
9Epileptic encephalopathy (HP:0200134)4.54601090
10Orthostatic hypotension (HP:0001278)4.38564658
11Flat capital femoral epiphysis (HP:0003370)4.25303795
12Neonatal hypoglycemia (HP:0001998)4.23628231
13Limb dystonia (HP:0002451)4.20477870
14Abnormal autonomic nervous system physiology (HP:0012332)3.87680411
15Type 2 muscle fiber atrophy (HP:0003554)3.80721244
16Amblyopia (HP:0000646)3.75887272
17Progressive cerebellar ataxia (HP:0002073)3.71196644
18Scanning speech (HP:0002168)3.49606406
19Visual hallucinations (HP:0002367)3.38146671
20Absence seizures (HP:0002121)3.33778501
21Large earlobe (HP:0009748)3.32523305
22Exotropia (HP:0000577)3.27730918
23Generalized tonic-clonic seizures (HP:0002069)3.21325536
24Ankle clonus (HP:0011448)3.13878439
25Dialeptic seizures (HP:0011146)3.11639436
26Hypoplastic left heart (HP:0004383)3.08872176
27Urinary bladder sphincter dysfunction (HP:0002839)3.04614532
28Progressive inability to walk (HP:0002505)2.97523654
29Muscle fiber atrophy (HP:0100295)2.95700314
30Torticollis (HP:0000473)2.95005246
31Spinal cord compression (HP:0002176)2.93713878
32Symphalangism affecting the phalanges of the hand (HP:0009773)2.88542936
33Abnormal drinking behavior (HP:0030082)2.88309970
34Polydipsia (HP:0001959)2.88309970
35Hyperthyroidism (HP:0000836)2.87182799
36Inability to walk (HP:0002540)2.85828339
37Protruding tongue (HP:0010808)2.81384104
38Abnormal hair whorl (HP:0010721)2.78271404
39Hip contracture (HP:0003273)2.76144447
40Hypoplastic heart (HP:0001961)2.70229702
41Irregular epiphyses (HP:0010582)2.67137808
42Flattened epiphyses (HP:0003071)2.66833588
43Stomach cancer (HP:0012126)2.65614875
44Postural instability (HP:0002172)2.64187892
45Spastic gait (HP:0002064)2.62768104
46Broad-based gait (HP:0002136)2.61294501
47Supranuclear gaze palsy (HP:0000605)2.60746844
48Hypoplasia of the iris (HP:0007676)2.60484111
49Hypomagnesemia (HP:0002917)2.59330073
50Glucose intolerance (HP:0000833)2.58565145
51Breech presentation (HP:0001623)2.58193303
52Papilledema (HP:0001085)2.57150901
53Absent speech (HP:0001344)2.56300089
54Visceral angiomatosis (HP:0100761)2.52749548
55Flat acetabular roof (HP:0003180)2.50210341
56Gaze-evoked nystagmus (HP:0000640)2.49891163
57Enlarged epiphyses (HP:0010580)2.49521058
58Poor eye contact (HP:0000817)2.46223220
59Genetic anticipation (HP:0003743)2.45629530
60Abnormal eating behavior (HP:0100738)2.42451014
61Insulin-resistant diabetes mellitus (HP:0000831)2.41054293
62Agammaglobulinemia (HP:0004432)2.40818731
63Hip dysplasia (HP:0001385)2.40217873
64Retinal dysplasia (HP:0007973)2.39308488
65Gait imbalance (HP:0002141)2.35846548
66Fetal akinesia sequence (HP:0001989)2.35390037
67Impaired social interactions (HP:0000735)2.32735648
68Abnormal social behavior (HP:0012433)2.32735648
69Bradycardia (HP:0001662)2.30019515
70Autoimmune hemolytic anemia (HP:0001890)2.29914623
71Hoarse voice (HP:0001609)2.28339289
72Hemangiomatosis (HP:0007461)2.28314308
73Blue irides (HP:0000635)2.28036502
74Syncope (HP:0001279)2.25197994
75Abnormality of B cell number (HP:0010975)2.22344960
76Clumsiness (HP:0002312)2.22097670
77Medial flaring of the eyebrow (HP:0010747)2.22029922
78Abnormality of binocular vision (HP:0011514)2.21868886
79Diplopia (HP:0000651)2.21868886
80Clonus (HP:0002169)2.21338747
81Limited hip movement (HP:0008800)2.20228435
82Bundle branch block (HP:0011710)2.19350511
83Aplasia/Hypoplasia of the lens (HP:0008063)2.18111013
84Abnormal cartilage morphology (HP:0002763)2.17452770
85Pheochromocytoma (HP:0002666)2.15346669
86Nephrogenic diabetes insipidus (HP:0009806)2.14810531
87Anxiety (HP:0000739)2.14222532
88Impaired vibration sensation in the lower limbs (HP:0002166)2.13836177
89Hypoventilation (HP:0002791)2.12737000
90Polyuria (HP:0000103)2.11075870
91Chin dimple (HP:0010751)2.10860664
92Congenital primary aphakia (HP:0007707)2.10683370
93Autoimmune thrombocytopenia (HP:0001973)2.09776653
94Eosinophilia (HP:0001880)2.09363200
95Genital tract atresia (HP:0001827)2.08665510
96Amelogenesis imperfecta (HP:0000705)2.07249882
97Hemiplegia (HP:0002301)2.06393725
98Atrial fibrillation (HP:0005110)2.05863535
99Primary atrial arrhythmia (HP:0001692)2.05800770
100Neuroendocrine neoplasm (HP:0100634)2.05331245
101Absent eyebrow (HP:0002223)2.05097878
102Generalized hypopigmentation of hair (HP:0011358)2.04974334
103Excessive salivation (HP:0003781)2.04251932
104Drooling (HP:0002307)2.04251932
105Abnormality of the corticospinal tract (HP:0002492)2.01925745
106Atrioventricular canal defect (HP:0006695)2.01307955
107Acute necrotizing encephalopathy (HP:0006965)2.01222014
108Tetany (HP:0001281)2.01050349
109Fair hair (HP:0002286)1.97361099
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96311139
111Degeneration of the lateral corticospinal tracts (HP:0002314)1.96311139
112Agitation (HP:0000713)1.95447111
113Weak cry (HP:0001612)1.95151473
114Mitral stenosis (HP:0001718)1.94249555
115Patent foramen ovale (HP:0001655)1.92521712
116Recurrent corneal erosions (HP:0000495)1.92517241
117Arterial tortuosity (HP:0005116)1.92442138
118Abnormality of incisor morphology (HP:0011063)1.92081293
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91998801
120Progressive macrocephaly (HP:0004481)1.90819743
121Abnormality of salivation (HP:0100755)1.90694375
122Abnormality of the prostate (HP:0008775)1.90678796
123Narrow nasal bridge (HP:0000446)1.90635338
124Impaired vibratory sensation (HP:0002495)1.89215919
125Focal dystonia (HP:0004373)1.89151712
126Supraventricular tachycardia (HP:0004755)1.89122389
127Neoplasm of head and neck (HP:0012288)1.88523166
128Esophageal neoplasm (HP:0100751)1.88523166
129Dysmetric saccades (HP:0000641)1.88504120
130Epileptiform EEG discharges (HP:0011182)1.87416979
131Elevated erythrocyte sedimentation rate (HP:0003565)1.84940989
132Lower limb muscle weakness (HP:0007340)1.84596266
133Polyphagia (HP:0002591)1.84216696
134B lymphocytopenia (HP:0010976)1.83763867
135Vascular tortuosity (HP:0004948)1.83652159
136Decreased muscle mass (HP:0003199)1.83543450
137Myotonia (HP:0002486)1.83003021
138Craniofacial dystonia (HP:0012179)1.82818861
139Vaginal atresia (HP:0000148)1.82130763
140Abnormal glucose tolerance (HP:0001952)1.82115079
141Abnormality of magnesium homeostasis (HP:0004921)1.81544817
142Slow saccadic eye movements (HP:0000514)1.81017750
143Status epilepticus (HP:0002133)1.80948075
144Aplasia involving bones of the upper limbs (HP:0009823)1.80733919
145Aplasia of the phalanges of the hand (HP:0009802)1.80733919
146Aplasia involving bones of the extremities (HP:0009825)1.80733919
147Supraventricular arrhythmia (HP:0005115)1.80593291
148EEG with generalized epileptiform discharges (HP:0011198)1.80394976
149Hyperaldosteronism (HP:0000859)1.80249539
150Increased corneal curvature (HP:0100692)1.80233127
151Keratoconus (HP:0000563)1.80233127
152Mesangial abnormality (HP:0001966)1.78640199
153Prolonged QT interval (HP:0001657)1.78372941
154Cubitus valgus (HP:0002967)1.78288396
155Abnormality of renin-angiotensin system (HP:0000847)1.78213072
156Abnormality of calcium-phosphate metabolism (HP:0100530)1.77437866
157Autoamputation (HP:0001218)1.76340534
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.76210023
159Decreased circulating renin level (HP:0003351)1.75830350
160Abnormal mitochondria in muscle tissue (HP:0008316)1.75628899
161Failure to thrive in infancy (HP:0001531)1.75284210
162Action tremor (HP:0002345)1.75073724
163Truncal ataxia (HP:0002078)1.74825714
164Aplasia of the musculature (HP:0100854)1.74553970
165Thyroid carcinoma (HP:0002890)1.74521172
166Gastroesophageal reflux (HP:0002020)1.73829393
167Ventricular fibrillation (HP:0001663)1.73020860
168Decreased central vision (HP:0007663)1.72347322
169Lissencephaly (HP:0001339)1.71834464
170Urethral obstruction (HP:0000796)1.71764473
171Abnormality of dental color (HP:0011073)1.67901179
172Dysautonomia (HP:0002459)1.64814565
173Thyroid-stimulating hormone excess (HP:0002925)1.64653836
174Pancreatic fibrosis (HP:0100732)1.64412094
175Xerostomia (HP:0000217)1.63579261
176Complete atrioventricular canal defect (HP:0001674)1.63414643
177Hypotension (HP:0002615)1.62437895
178Hypsarrhythmia (HP:0002521)1.61870496
179Dynein arm defect of respiratory motile cilia (HP:0012255)1.59472055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.34052645
2MAP2K73.74958530
3CASK3.43147259
4NTRK33.40914215
5PDK23.37247889
6NTRK13.27095844
7MAP3K123.23454269
8MAP3K43.06613399
9GRK72.81529530
10AKT32.67890744
11GRK52.43767393
12MYLK2.21379577
13NLK2.15538701
14JAK12.07501495
15PLK22.04933396
16CSNK1G11.94864477
17SIK31.90110482
18MAP2K41.87137145
19KIT1.85265307
20MAP4K21.83455902
21EPHA41.81006445
22MINK11.74426968
23RIPK41.70580264
24TNIK1.67535443
25MAPK131.64832654
26INSRR1.62744961
27MARK11.60233995
28PRPF4B1.55847460
29DAPK21.50680736
30BMPR21.49395033
31PRKCE1.46531792
32PNCK1.44621939
33PDGFRA1.39379049
34SGK21.37231848
35TEC1.33618595
36CAMK41.26716848
37MAP3K61.22250240
38PDGFRB1.21890857
39CAMKK21.20931663
40MAPKAPK51.18536766
41MATK1.18110878
42SIK21.17693665
43ADRBK21.17506333
44CDK191.16544780
45NTRK21.14290341
46DAPK11.12569207
47ZAK1.11142542
48PDK11.10971684
49SGK2231.10574074
50SGK4941.10574074
51PIK3CG1.08942088
52YES11.07822714
53PTK2B1.06570172
54JAK21.03545177
55ADRBK11.00987654
56ERBB40.99804134
57MUSK0.98434446
58PRKCG0.97872418
59MAP3K90.96693316
60PDPK10.96442023
61OBSCN0.95596374
62CAMK2A0.93025234
63TRPM70.89276457
64STK240.88826204
65CSNK1G20.87591937
66DYRK1A0.87068931
67STK110.86927115
68BMPR1B0.86828444
69CDK50.86288022
70TSSK60.83289318
71MAP2K60.82156591
72RET0.79050983
73UHMK10.77808714
74CAMK10.76812512
75SGK30.73812745
76PIK3CA0.73046635
77SYK0.72329989
78NEK60.71593365
79MARK20.71538913
80MAP3K70.71530987
81CAMKK10.71175609
82FRK0.69949346
83OXSR10.68559102
84FGR0.68552040
85MAP2K10.68037866
86CDC42BPA0.67853166
87CAMK2B0.67599542
88WNK10.67516834
89CDK80.67070684
90MAP3K140.66463730
91ARAF0.65086197
92FES0.62769064
93CAMK2D0.59662885
94LATS20.59388116
95MAPKAPK30.58723845
96CSNK1G30.58578025
97CSNK1D0.57360120
98MAP3K20.56836459
99NME10.55551449
100PRKCQ0.54843242
101MAP3K130.54663057
102PRKCA0.53582279
103SGK10.52891319
104GRK60.52229771
105PRKD30.51771955
106ERBB30.51476451
107FGFR20.51121072
108CSNK1A10.49605668
109PRKD10.49360950
110CAMK2G0.48480237
111GRK10.48391265
112MELK0.47301163
113CCNB10.47193524
114CDK30.46863792
115EEF2K0.46534915
116RPS6KA60.45693207
117BCR0.45497415
118MAPK150.45354800
119RPS6KA30.44962468
120PAK60.41827742
121MAP3K50.41478460
122PRKG10.41277880
123PRKACA0.40952377
124PRKCH0.40513955
125RPS6KA20.39943176
126MAPK120.39907820
127CDK180.39703975
128PLK30.39519021
129STK380.39517823
130MKNK10.39325904
131KSR10.39319502
132ALK0.37687794
133FER0.36741636
134SCYL20.36610211
135KSR20.36208765
136PHKG10.35752747
137PHKG20.35752747
138PINK10.35085189
139PKN10.34776102
140PRKCB0.34753189
141MAPK70.34611640
142BRAF0.34158190
143TIE10.33652424
144PAK30.33636692
145CDK140.33585946
146DAPK30.33463496
147ABL20.32701626

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007704.90403654
2Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007603.56614099
3Nicotine addiction_Homo sapiens_hsa050333.49921250
4Synaptic vesicle cycle_Homo sapiens_hsa047213.34669510
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.68608291
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62300198
7Collecting duct acid secretion_Homo sapiens_hsa049662.59839646
8Serotonergic synapse_Homo sapiens_hsa047262.49804029
9Amphetamine addiction_Homo sapiens_hsa050312.43486189
10GABAergic synapse_Homo sapiens_hsa047272.34921136
11Morphine addiction_Homo sapiens_hsa050322.29680769
12Circadian entrainment_Homo sapiens_hsa047132.26389672
13Olfactory transduction_Homo sapiens_hsa047402.19925675
14Taste transduction_Homo sapiens_hsa047422.15379745
15Dopaminergic synapse_Homo sapiens_hsa047282.12339457
16Cholinergic synapse_Homo sapiens_hsa047252.11217732
17Glutamatergic synapse_Homo sapiens_hsa047242.07896904
18Cocaine addiction_Homo sapiens_hsa050302.01069029
19Oxidative phosphorylation_Homo sapiens_hsa001901.88057108
20* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86295804
21Long-term potentiation_Homo sapiens_hsa047201.83893745
22Salivary secretion_Homo sapiens_hsa049701.78239922
23Fatty acid biosynthesis_Homo sapiens_hsa000611.78035979
24Long-term depression_Homo sapiens_hsa047301.77825508
25Insulin secretion_Homo sapiens_hsa049111.70772827
26Renin secretion_Homo sapiens_hsa049241.67153923
27Type I diabetes mellitus_Homo sapiens_hsa049401.61719484
28Calcium signaling pathway_Homo sapiens_hsa040201.56193971
29Tyrosine metabolism_Homo sapiens_hsa003501.55524922
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50655778
31Vibrio cholerae infection_Homo sapiens_hsa051101.46370486
32Cardiac muscle contraction_Homo sapiens_hsa042601.43814019
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40482960
34Rheumatoid arthritis_Homo sapiens_hsa053231.39308149
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.38986521
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.38864544
37Parkinsons disease_Homo sapiens_hsa050121.36753610
38Oxytocin signaling pathway_Homo sapiens_hsa049211.34817106
39Phenylalanine metabolism_Homo sapiens_hsa003601.34653044
40Alzheimers disease_Homo sapiens_hsa050101.32409663
41Gastric acid secretion_Homo sapiens_hsa049711.31623718
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31097881
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31015045
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26505308
45African trypanosomiasis_Homo sapiens_hsa051431.23079598
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.22344790
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21415226
48Selenocompound metabolism_Homo sapiens_hsa004501.16578406
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15338400
50Dilated cardiomyopathy_Homo sapiens_hsa054141.09098910
51GnRH signaling pathway_Homo sapiens_hsa049121.08889494
52Gap junction_Homo sapiens_hsa045401.03366450
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02087070
54cAMP signaling pathway_Homo sapiens_hsa040241.01323949
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99866850
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91373851
57Platelet activation_Homo sapiens_hsa046110.87435879
58Huntingtons disease_Homo sapiens_hsa050160.85726852
59Starch and sucrose metabolism_Homo sapiens_hsa005000.82924564
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82148368
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81129254
62Estrogen signaling pathway_Homo sapiens_hsa049150.77401522
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77128418
64Type II diabetes mellitus_Homo sapiens_hsa049300.77020827
65Tryptophan metabolism_Homo sapiens_hsa003800.76649761
66Vitamin B6 metabolism_Homo sapiens_hsa007500.76103831
67Axon guidance_Homo sapiens_hsa043600.75516938
68Phagosome_Homo sapiens_hsa041450.74968857
69Melanogenesis_Homo sapiens_hsa049160.74585751
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.73302298
71Sulfur metabolism_Homo sapiens_hsa009200.72801172
72mTOR signaling pathway_Homo sapiens_hsa041500.70743529
73Pancreatic secretion_Homo sapiens_hsa049720.68758132
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68326018
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68191836
76Phototransduction_Homo sapiens_hsa047440.66859927
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66090724
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66005268
79Asthma_Homo sapiens_hsa053100.64292667
80Circadian rhythm_Homo sapiens_hsa047100.63281666
81ErbB signaling pathway_Homo sapiens_hsa040120.63275343
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62029295
83Ovarian steroidogenesis_Homo sapiens_hsa049130.61853180
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59192743
85Thyroid hormone synthesis_Homo sapiens_hsa049180.57549339
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56952412
87Prolactin signaling pathway_Homo sapiens_hsa049170.54464444
88Histidine metabolism_Homo sapiens_hsa003400.52369456
89MAPK signaling pathway_Homo sapiens_hsa040100.49760295
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49439739
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48523114
92Glioma_Homo sapiens_hsa052140.48194062
93Ras signaling pathway_Homo sapiens_hsa040140.47977167
94Glycerolipid metabolism_Homo sapiens_hsa005610.47664858
95Protein digestion and absorption_Homo sapiens_hsa049740.47179084
96Inositol phosphate metabolism_Homo sapiens_hsa005620.44882065
97Alcoholism_Homo sapiens_hsa050340.43621330
98Oocyte meiosis_Homo sapiens_hsa041140.43521149
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.43049321
100VEGF signaling pathway_Homo sapiens_hsa043700.42831343
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42241776
102Rap1 signaling pathway_Homo sapiens_hsa040150.42040538
103FoxO signaling pathway_Homo sapiens_hsa040680.41396685
104Autoimmune thyroid disease_Homo sapiens_hsa053200.40795221
105Melanoma_Homo sapiens_hsa052180.40670751
106B cell receptor signaling pathway_Homo sapiens_hsa046620.38711441
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36944853
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35512465
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35254625
110Ether lipid metabolism_Homo sapiens_hsa005650.35002747
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33306227
112Purine metabolism_Homo sapiens_hsa002300.32715347
113Wnt signaling pathway_Homo sapiens_hsa043100.32436118
114Choline metabolism in cancer_Homo sapiens_hsa052310.32314746
115Nitrogen metabolism_Homo sapiens_hsa009100.31210463
116ABC transporters_Homo sapiens_hsa020100.30966139
117Butanoate metabolism_Homo sapiens_hsa006500.30838993
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30226640
119Graft-versus-host disease_Homo sapiens_hsa053320.29880782
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28066710
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27751810
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.27716857
123Glucagon signaling pathway_Homo sapiens_hsa049220.27315854
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24757971
125Mineral absorption_Homo sapiens_hsa049780.24499707
126Chemokine signaling pathway_Homo sapiens_hsa040620.19673273
127Tuberculosis_Homo sapiens_hsa051520.19427622
128Salmonella infection_Homo sapiens_hsa051320.19282906
129Dorso-ventral axis formation_Homo sapiens_hsa043200.19261112
130Amoebiasis_Homo sapiens_hsa051460.17744626
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.14421094
132Pertussis_Homo sapiens_hsa051330.12763052
133Allograft rejection_Homo sapiens_hsa053300.12574038

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