RXFP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of centriole replication (GO:0046599)9.83757223
2coronary vasculature morphogenesis (GO:0060977)9.63209025
3lung lobe morphogenesis (GO:0060463)9.60240042
4auditory receptor cell stereocilium organization (GO:0060088)8.63411170
5positive regulation of dendritic spine morphogenesis (GO:0061003)8.02930478
6phospholipid scrambling (GO:0017121)7.81761430
7cellular response to ATP (GO:0071318)7.53979718
8regulation of skeletal muscle contraction (GO:0014819)7.49452027
9protein targeting to plasma membrane (GO:0072661)7.39517664
10negative regulation of cell aging (GO:0090344)7.34975684
11glial cell migration (GO:0008347)7.08754865
12negative regulation of protein localization to cell surface (GO:2000009)7.03065188
13protein carboxylation (GO:0018214)7.01278426
14peptidyl-glutamic acid carboxylation (GO:0017187)7.01278426
15galactose catabolic process (GO:0019388)6.76888542
16G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.74597820
17regulation of ER to Golgi vesicle-mediated transport (GO:0060628)6.69381918
18mitotic cell cycle arrest (GO:0071850)6.51229798
19GDP-mannose metabolic process (GO:0019673)6.37035881
20vesicle fusion (GO:0006906)6.34457974
21DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla6.32172604
22DNA strand renaturation (GO:0000733)6.23443536
23adenosine receptor signaling pathway (GO:0001973)6.17833751
24purinergic nucleotide receptor signaling pathway (GO:0035590)6.15366140
25regulation of cytokine production involved in inflammatory response (GO:1900015)6.01606149
26negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.96518797
27regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.96487551
28regulation of synapse structural plasticity (GO:0051823)5.91670656
29inner ear receptor stereocilium organization (GO:0060122)5.70322229
30lens fiber cell differentiation (GO:0070306)5.70101151
31negative regulation of telomerase activity (GO:0051974)5.68834961
32regulation of dendritic spine morphogenesis (GO:0061001)5.59404845
33postsynaptic membrane organization (GO:0001941)5.55046159
34transepithelial transport (GO:0070633)5.48908440
35keratan sulfate catabolic process (GO:0042340)5.48398880
36detection of light stimulus involved in sensory perception (GO:0050962)5.47689897
37detection of light stimulus involved in visual perception (GO:0050908)5.47689897
38negative regulation of DNA biosynthetic process (GO:2000279)5.47607779
39DNA damage response, signal transduction resulting in transcription (GO:0042772)5.47044121
40negative regulation of interleukin-2 production (GO:0032703)5.37729531
41meiotic chromosome segregation (GO:0045132)5.33197728
42interferon-gamma production (GO:0032609)5.24823120
43response to ATP (GO:0033198)4.94072530
44negative regulation of interleukin-8 production (GO:0032717)4.90503766
45anatomical structure maturation (GO:0071695)4.87393705
46polarized epithelial cell differentiation (GO:0030859)4.85584862
47positive regulation of establishment of protein localization to plasma membrane (GO:0090004)4.73664715
48presynaptic membrane assembly (GO:0097105)4.71992177
49positive regulation of dendritic spine development (GO:0060999)4.69377168
50detection of molecule of bacterial origin (GO:0032490)4.62305992
51tachykinin receptor signaling pathway (GO:0007217)4.62158403
52positive regulation of protein localization to plasma membrane (GO:1903078)4.55582896
53purinergic receptor signaling pathway (GO:0035587)4.55029919
54granulocyte differentiation (GO:0030851)4.50818807
55neuron projection regeneration (GO:0031102)4.39575667
56mannose metabolic process (GO:0006013)4.38595582
57positive regulation of heat generation (GO:0031652)4.37347432
58retina vasculature morphogenesis in camera-type eye (GO:0061299)4.31986809
59COPII vesicle coating (GO:0048208)4.27191378
60short-term memory (GO:0007614)4.25999161
61phosphatidylglycerol biosynthetic process (GO:0006655)4.13867267
62vocalization behavior (GO:0071625)4.12843270
63G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.11881609
64regulation of dendritic spine development (GO:0060998)4.09510120
65regulation of establishment of planar polarity (GO:0090175)4.02399394
66regulation of interferon-beta biosynthetic process (GO:0045357)4.01356001
67cornea development in camera-type eye (GO:0061303)3.97221227
68sensory perception of taste (GO:0050909)3.96687953
69aorta morphogenesis (GO:0035909)3.96659386
70response to gravity (GO:0009629)3.94926575
71estrogen biosynthetic process (GO:0006703)3.88912654
72regulation of centrosome duplication (GO:0010824)3.80399365
73sphingomyelin metabolic process (GO:0006684)3.78092536
74negative regulation of fibroblast apoptotic process (GO:2000270)3.76621550
75cellular response to estradiol stimulus (GO:0071392)3.74107804
76positive regulation of protein kinase C signaling (GO:0090037)3.71861391
77presynaptic membrane organization (GO:0097090)3.71732655
78rRNA methylation (GO:0031167)3.67729819
79semaphorin-plexin signaling pathway (GO:0071526)3.64756967
80sphingosine metabolic process (GO:0006670)3.58548416
81oligosaccharide catabolic process (GO:0009313)3.53451850
82phagocytosis, engulfment (GO:0006911)3.52624553
83cardiolipin metabolic process (GO:0032048)3.49341768
84positive thymic T cell selection (GO:0045059)3.49182990
85regulation of phospholipid biosynthetic process (GO:0071071)3.41045008
86negative regulation of toll-like receptor signaling pathway (GO:0034122)3.38482206
87epithelial cell fate commitment (GO:0072148)3.36099691
88diol metabolic process (GO:0034311)3.34135279
89negative regulation of smooth muscle cell differentiation (GO:0051151)3.34009754
90oligodendrocyte differentiation (GO:0048709)3.33019203
91response to peptidoglycan (GO:0032494)3.32315866
92positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.31146198
93galactose metabolic process (GO:0006012)3.30555497
94sympathetic nervous system development (GO:0048485)3.30202735
95detection of external biotic stimulus (GO:0098581)3.26754423
96positive regulation of vascular permeability (GO:0043117)3.26578420
97regulation of membrane lipid distribution (GO:0097035)3.22360144
98UV protection (GO:0009650)3.21639703
99phosphatidylethanolamine biosynthetic process (GO:0006646)3.21187677
100neuronal action potential (GO:0019228)3.19890417
101histone phosphorylation (GO:0016572)3.18124555
102dendrite development (GO:0016358)3.16187677
103regulation of heat generation (GO:0031650)3.16140941
104positive T cell selection (GO:0043368)3.15739834
105cellular anion homeostasis (GO:0030002)3.15058706
106neuron cell-cell adhesion (GO:0007158)3.11085040
107asymmetric protein localization (GO:0008105)3.09280202
108regulation of cell aging (GO:0090342)3.09051714
109negative regulation of JAK-STAT cascade (GO:0046426)3.08387526
110urinary tract smooth muscle contraction (GO:0014848)3.06817514
111response to muramyl dipeptide (GO:0032495)3.06762498
112pathway-restricted SMAD protein phosphorylation (GO:0060389)3.05666403
113histone H3-K36 demethylation (GO:0070544)3.03837960
114behavioral response to nicotine (GO:0035095)3.03505865
115urogenital system development (GO:0001655)3.02576781
116sodium ion homeostasis (GO:0055078)3.01431743
117trivalent inorganic anion homeostasis (GO:0072506)3.00992053
118phosphate ion homeostasis (GO:0055062)3.00992053
119mitochondrion distribution (GO:0048311)3.00500589
120mast cell degranulation (GO:0043303)3.00019334
121mast cell activation involved in immune response (GO:0002279)3.00019334
122purine ribonucleotide transport (GO:0015868)2.96979482
123plasma membrane repair (GO:0001778)2.96947306
124peristalsis (GO:0030432)2.96886780
125negative regulation of activin receptor signaling pathway (GO:0032926)2.95760297
126cilium or flagellum-dependent cell motility (GO:0001539)2.95090509
127myelin maintenance (GO:0043217)2.94787218
128regulation of telomerase activity (GO:0051972)2.92433561
129negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.92274305
130peptidyl-glutamic acid modification (GO:0018200)2.91261006
131peripheral nervous system development (GO:0007422)2.89062157
132regulation of activin receptor signaling pathway (GO:0032925)2.88768191
133sulfur amino acid catabolic process (GO:0000098)2.88635397
134positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.88156780
135positive regulation of gamma-delta T cell activation (GO:0046645)2.88049296
136endocytic recycling (GO:0032456)2.87886199
137inositol phosphate-mediated signaling (GO:0048016)2.87816153
138positive regulation of dendrite morphogenesis (GO:0050775)2.86742740
139sleep (GO:0030431)2.85825965
140detection of biotic stimulus (GO:0009595)2.85007805
141establishment of protein localization to plasma membrane (GO:0090002)2.84132831
142membrane assembly (GO:0071709)2.83559970
143regulation of centrosome cycle (GO:0046605)2.83019108
144cellular response to electrical stimulus (GO:0071257)2.79061224
145phosphatidylethanolamine metabolic process (GO:0046337)2.78519721
146atrial septum morphogenesis (GO:0060413)2.77436809
147membrane depolarization during action potential (GO:0086010)2.75764478
148rRNA modification (GO:0000154)2.75557770
149regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.74780771
150regulation of dendrite morphogenesis (GO:0048814)2.74021372
151cellular response to gonadotropin stimulus (GO:0071371)2.73396581
152regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.72237522
153grooming behavior (GO:0007625)2.70920819
154regulation of fibroblast apoptotic process (GO:2000269)2.70443590
155positive regulation of sodium ion transmembrane transport (GO:1902307)2.69735460
156positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)2.69682748
157negative regulation of tumor necrosis factor production (GO:0032720)2.69455622
158positive regulation of interferon-alpha production (GO:0032727)2.67786004
159regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67091497
160nucleotide transmembrane transport (GO:1901679)2.66523398
161male sex determination (GO:0030238)2.65942887
162sialylation (GO:0097503)2.65271298
163cellular extravasation (GO:0045123)2.63918019
164regulation of interferon-beta production (GO:0032648)2.63524597
165myelination in peripheral nervous system (GO:0022011)2.62208114
166peripheral nervous system axon ensheathment (GO:0032292)2.62208114
167negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.61746611
168positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.59778609
169regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.59778609
170nucleotide-sugar biosynthetic process (GO:0009226)2.59309305
171muscle cell fate commitment (GO:0042693)2.58877040
172mast cell activation (GO:0045576)2.58873035
173regulation of establishment of protein localization to plasma membrane (GO:0090003)2.58294973
174histone H4 deacetylation (GO:0070933)2.58210036
175adenine nucleotide transport (GO:0051503)2.57880152
176negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.57800125
177phosphate ion transmembrane transport (GO:0035435)2.57425346
178regulation of guanylate cyclase activity (GO:0031282)2.57269032
179regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56924502
180sex determination (GO:0007530)2.56509886
181regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.56216046
182positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.56216046
183positive regulation of proteasomal protein catabolic process (GO:1901800)2.56118587
184negative regulation of erythrocyte differentiation (GO:0045647)2.56055191
185membrane invagination (GO:0010324)2.55269989
186sphingoid metabolic process (GO:0046519)2.51583030
187negative regulation of TOR signaling (GO:0032007)2.49398910
188purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.48894538
1893-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.48894538
190type B pancreatic cell proliferation (GO:0044342)2.48831369
191myeloid cell activation involved in immune response (GO:0002275)2.47141307
192purine deoxyribonucleotide catabolic process (GO:0009155)2.46819371
193melanin metabolic process (GO:0006582)2.45519040
194regulation of interferon-alpha production (GO:0032647)2.44870383
195leukocyte degranulation (GO:0043299)2.39049302
196blood vessel maturation (GO:0001955)11.4276998
197tooth mineralization (GO:0034505)10.7459694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.98740148
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.41280444
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.52880224
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.46229650
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.26642351
6TP53_16413492_ChIP-PET_HCT116_Human3.14959940
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.04619569
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.86489806
9* VDR_24763502_ChIP-Seq_THP-1_Human2.83935064
10* MAF_26560356_Chip-Seq_TH2_Human2.80763806
11P68_20966046_ChIP-Seq_HELA_Human2.78321549
12* MAF_26560356_Chip-Seq_TH1_Human2.59953829
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53198681
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53198681
15MYC_22102868_ChIP-Seq_BL_Human2.51166427
16AR_21572438_ChIP-Seq_LNCaP_Human2.36222512
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.33930381
18BCL6_27268052_Chip-Seq_Bcells_Human2.26811806
19BCOR_27268052_Chip-Seq_Bcells_Human2.25543523
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.23907053
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23636723
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23460556
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22876692
24E2F1_20622854_ChIP-Seq_HELA_Human2.21107729
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.20963851
26XRN2_22483619_ChIP-Seq_HELA_Human2.18573073
27UTX_26944678_Chip-Seq_JUKART_Human2.16942757
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14061547
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12584882
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12522588
31RUNX_20019798_ChIP-Seq_JUKART_Human2.08589663
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07643437
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.05285334
34MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04266968
35CTCF_27219007_Chip-Seq_ERYTHROID_Human2.01580507
36PHF8_20622854_ChIP-Seq_HELA_Human1.98002156
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.97016104
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.96949244
39TCF7_22412390_ChIP-Seq_EML_Mouse1.96909643
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.94408600
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.93908941
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.92712600
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90506449
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.89979925
45* RACK7_27058665_Chip-Seq_MCF-7_Human1.87806273
46KDM2B_26808549_Chip-Seq_DND41_Human1.87540570
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85707969
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85238311
49* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.84242335
50CIITA_25753668_ChIP-Seq_RAJI_Human1.81477484
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.78330061
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77967270
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.73988446
54RARB_24833708_ChIP-Seq_LIVER_Mouse1.71511641
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71153906
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69248396
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69132276
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.67996454
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67106399
60RXRA_24833708_ChIP-Seq_LIVER_Mouse1.66338341
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.64542803
62* CTCF_27219007_Chip-Seq_Bcells_Human1.63823950
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63002649
64CTCF_21964334_Chip-Seq_Bcells_Human1.62066520
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.60238383
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.60169015
67SMC4_20622854_ChIP-Seq_HELA_Human1.59929034
68* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59431156
69CJUN_26792858_Chip-Seq_BT549_Human1.57821437
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57124799
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.56833163
72KDM2B_26808549_Chip-Seq_K562_Human1.56439369
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.55219599
74* RARA_24833708_ChIP-Seq_LIVER_Mouse1.54798102
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.54400051
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.53614179
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52377242
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.52121977
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.50459934
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.49719340
81CTCF_21964334_ChIP-Seq_BJAB-B_Human1.49221797
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46301425
83FOXP1_21924763_ChIP-Seq_HESCs_Human1.45714670
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43959712
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.43209172
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.42653851
87TP53_22127205_ChIP-Seq_IMR90_Human1.42310209
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.42294695
89* SA1_27219007_Chip-Seq_ERYTHROID_Human1.41713413
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41497001
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41295754
92GATA1_19941826_ChIP-Seq_K562_Human1.40806437
93CREB1_26743006_Chip-Seq_LNCaP_Human1.37685427
94TP53_18474530_ChIP-ChIP_U2OS_Human1.37603733
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36576888
96BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36162811
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.35205211
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.35152113
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.34719947
100YY1_22570637_ChIP-Seq_MALME-3M_Human1.34417828
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.34255443
102RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33759223
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33170871
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32252075
105EZH2_22144423_ChIP-Seq_EOC_Human1.32210484
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31099954
107CTCF_20526341_ChIP-Seq_ESCs_Human1.30291156
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29636502
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29049732
110EZH2_27304074_Chip-Seq_ESCs_Mouse1.28946449
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28855276
112ETS1_21867929_ChIP-Seq_TH2_Mouse1.28283489
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28246099
114SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27052192
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25796843
116PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25777275
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23691339
118AHR_22903824_ChIP-Seq_MCF-7_Human1.22870474
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22766451
120P300_27268052_Chip-Seq_Bcells_Human1.22695996
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22568207
122BRD4_25478319_ChIP-Seq_HGPS_Human1.21486571
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21420006
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21372526
125NCOR1_26117541_ChIP-Seq_K562_Human1.21324485
126TP53_20018659_ChIP-ChIP_R1E_Mouse1.19867006
127* IRF8_21731497_ChIP-ChIP_J774_Mouse1.19632851
128TET1_21490601_ChIP-Seq_MESCs_Mouse1.19025503
129MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18905097
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18692284
131EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17498880
132* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16915990
133RUNX1_27514584_Chip-Seq_MCF-7_Human1.16075175
134GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15688415
135EGR1_19032775_ChIP-ChIP_M12_Human1.15375197
136STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15024908
137FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14588221
138CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14254289
139NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13259646
140JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12683075
141CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12037242
142DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10477194
143WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09948656
144ERA_21632823_ChIP-Seq_H3396_Human1.08871883
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08183244
146* ATF3_27146783_Chip-Seq_COLON_Human1.08175421
147UBF1/2_26484160_Chip-Seq_HMECs_Human1.06890139
148SA1_27219007_Chip-Seq_Bcells_Human1.06552711
149MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05788795
150NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05249963
151SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04705932
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04613437
153KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04425581
154SPI1_23547873_ChIP-Seq_NB4_Human1.04132674
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04046330
156YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03089538
157NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03041904
158CTCF_26484167_Chip-Seq_Bcells_Mouse1.02907738
159UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02869140
160THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02641149
161RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02285945
162GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02139296
163GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00694572
164TAF15_26573619_Chip-Seq_HEK293_Human1.00495045
165CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00173544
166DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99479253
167LXR_22292898_ChIP-Seq_THP-1_Human0.99210332
168SPI1_23127762_ChIP-Seq_K562_Human0.98960349
169BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98907960
170FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98722287
171DROSHA_22980978_ChIP-Seq_HELA_Human0.98632263
172OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98076988
173MYC_27129775_Chip-Seq_CORNEA_Mouse0.95173498
174ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94785325
175STAT1_20625510_ChIP-Seq_HELA_Human0.94020459
176PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94018128
177SOX2_21211035_ChIP-Seq_LN229_Gbm0.90562861
178LXR_22158963_ChIP-Seq_LIVER_Mouse0.89777518
179KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88069205
180PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.86438890
181BP1_19119308_ChIP-ChIP_Hs578T_Human0.86189009
182ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85302735
183SCL_19346495_ChIP-Seq_HPC-7_Human0.84269166
184HTT_18923047_ChIP-ChIP_STHdh_Human0.83763350
185KDM2B_26808549_Chip-Seq_JURKAT_Human0.80687448
186RXR_22158963_ChIP-Seq_LIVER_Mouse0.80082216
187AR_19668381_ChIP-Seq_PC3_Human0.79434967
188CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79305064
189SMAD4_21799915_ChIP-Seq_A2780_Human0.78941038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.82647341
2MP0005171_absent_coat_pigmentation6.64648470
3MP0005174_abnormal_tail_pigmentation5.80527407
4MP0004272_abnormal_basement_membrane5.71084030
5MP0002837_dystrophic_cardiac_calcinosis5.54367156
6MP0009780_abnormal_chondrocyte_physiolo4.98120010
7MP0005423_abnormal_somatic_nervous4.09749437
8MP0003724_increased_susceptibility_to4.05744888
9MP0003045_fibrosis3.73681654
10MP0003136_yellow_coat_color3.42474372
11MP0005409_darkened_coat_color3.39746440
12MP0005076_abnormal_cell_differentiation3.05227026
13MP0008875_abnormal_xenobiotic_pharmacok2.92317217
14MP0001348_abnormal_lacrimal_gland2.89235060
15MP0008260_abnormal_autophagy2.87052716
16MP0003705_abnormal_hypodermis_morpholog2.77599878
17MP0003690_abnormal_glial_cell2.77081577
18MP0000751_myopathy2.64548768
19MP0001188_hyperpigmentation2.63940478
20MP0000015_abnormal_ear_pigmentation2.51228694
21MP0001529_abnormal_vocalization2.47397454
22MP0005083_abnormal_biliary_tract2.45746005
23MP0001756_abnormal_urination2.28329962
24MP0004147_increased_porphyrin_level2.11388231
25MP0003453_abnormal_keratinocyte_physiol2.07444647
26MP0001661_extended_life_span2.04791783
27MP0001486_abnormal_startle_reflex2.00731729
28MP0001984_abnormal_olfaction1.99561765
29MP0003137_abnormal_impulse_conducting1.91169122
30MP0002909_abnormal_adrenal_gland1.88779477
31MP0004859_abnormal_synaptic_plasticity1.84647434
32MP0004130_abnormal_muscle_cell1.82866205
33MP0003011_delayed_dark_adaptation1.81977124
34MP0003172_abnormal_lysosome_physiology1.79065891
35MP0005645_abnormal_hypothalamus_physiol1.75988809
36MP0002653_abnormal_ependyma_morphology1.73682240
37MP0008961_abnormal_basal_metabolism1.63569694
38MP0005365_abnormal_bile_salt1.61347730
39MP0000678_abnormal_parathyroid_gland1.61327425
40MP0003436_decreased_susceptibility_to1.60157838
41MP0010368_abnormal_lymphatic_system1.59451151
42MP0000538_abnormal_urinary_bladder1.59302965
43MP0003385_abnormal_body_wall1.57593216
44MP0002638_abnormal_pupillary_reflex1.52739670
45MP0005058_abnormal_lysosome_morphology1.52122227
46MP0001919_abnormal_reproductive_system1.47386827
47MP0003634_abnormal_glial_cell1.46091676
48MP0001765_abnormal_ion_homeostasis1.43154424
49MP0002168_other_aberrant_phenotype1.42732939
50MP0000920_abnormal_myelination1.42319933
51MP0008438_abnormal_cutaneous_collagen1.41799276
52MP0001502_abnormal_circadian_rhythm1.41048872
53MP0001835_abnormal_antigen_presentation1.40173621
54MP0002751_abnormal_autonomic_nervous1.39632602
55MP0001849_ear_inflammation1.39573658
56MP0002160_abnormal_reproductive_system1.38077300
57MP0003943_abnormal_hepatobiliary_system1.36844755
58MP0005166_decreased_susceptibility_to1.36778158
59MP0001340_abnormal_eyelid_morphology1.33392866
60MP0001968_abnormal_touch/_nociception1.32602380
61MP0005410_abnormal_fertilization1.27918279
62MP0000749_muscle_degeneration1.26881767
63MP0006082_CNS_inflammation1.25306741
64MP0009840_abnormal_foam_cell1.21552112
65MP0010155_abnormal_intestine_physiology1.18945976
66MP0003091_abnormal_cell_migration1.18618853
67MP0003763_abnormal_thymus_physiology1.17704250
68MP0000750_abnormal_muscle_regeneration1.17036710
69MP0001800_abnormal_humoral_immune1.16657933
70MP0009278_abnormal_bone_marrow1.16148621
71MP0002723_abnormal_immune_serum1.13293379
72MP0009384_cardiac_valve_regurgitation1.13230782
73MP0005386_behavior/neurological_phenoty1.11723302
74MP0004924_abnormal_behavior1.11723302
75MP0002557_abnormal_social/conspecific_i1.09491083
76MP0002933_joint_inflammation1.09113891
77MP0002452_abnormal_antigen_presenting1.08767564
78MP0005501_abnormal_skin_physiology1.08451703
79MP0005332_abnormal_amino_acid1.07509171
80MP0000470_abnormal_stomach_morphology1.06022301
81MP0002063_abnormal_learning/memory/cond1.04607597
82MP0001873_stomach_inflammation1.03696088
83MP0005084_abnormal_gallbladder_morpholo1.01095727
84MP0005025_abnormal_response_to1.00450116
85MP0002398_abnormal_bone_marrow1.00372132
86MP0004381_abnormal_hair_follicle0.99660054
87MP0000685_abnormal_immune_system0.98923670
88MP0003806_abnormal_nucleotide_metabolis0.98293896
89MP0003566_abnormal_cell_adhesion0.98234573
90MP0000013_abnormal_adipose_tissue0.97714552
91MP0002420_abnormal_adaptive_immunity0.96367422
92MP0002419_abnormal_innate_immunity0.96340170
93MP0001533_abnormal_skeleton_physiology0.96013277
94MP0001819_abnormal_immune_cell0.95518151
95MP0002009_preneoplasia0.95480341
96MP0004858_abnormal_nervous_system0.93671579
97MP0002064_seizures0.92734732
98MP0004947_skin_inflammation0.92714014
99MP0003635_abnormal_synaptic_transmissio0.92539387
100MP0002139_abnormal_hepatobiliary_system0.92510875
101MP0005387_immune_system_phenotype0.91686011
102MP0001790_abnormal_immune_system0.91686011
103MP0000343_altered_response_to0.90286383
104MP0003111_abnormal_nucleus_morphology0.89664043
105MP0000367_abnormal_coat/_hair0.89028442
106MP0004484_altered_response_of0.87049028
107MP0005584_abnormal_enzyme/coenzyme_acti0.86545045
108MP0003448_altered_tumor_morphology0.86297229
109MP0000716_abnormal_immune_system0.85982783
110MP0006072_abnormal_retinal_apoptosis0.85793267
111MP0001879_abnormal_lymphatic_vessel0.85677417
112MP0002019_abnormal_tumor_incidence0.84933732
113MP0009643_abnormal_urine_homeostasis0.84512593
114MP0002254_reproductive_system_inflammat0.84231911
115MP0003632_abnormal_nervous_system0.82998534
116MP0010329_abnormal_lipoprotein_level0.82766743
117MP0001501_abnormal_sleep_pattern0.82268150
118MP0003935_abnormal_craniofacial_develop0.82256755
119MP0001664_abnormal_digestion0.82048493
120MP0005000_abnormal_immune_tolerance0.81850272
121MP0002429_abnormal_blood_cell0.80847446
122MP0002075_abnormal_coat/hair_pigmentati0.79843490
123MP0003303_peritoneal_inflammation0.79539488
124MP0002136_abnormal_kidney_physiology0.79003471
125MP0003122_maternal_imprinting0.78886095
126MP0005385_cardiovascular_system_phenoty0.77006225
127MP0001544_abnormal_cardiovascular_syste0.77006225
128MP0000569_abnormal_digit_pigmentation0.76587328
129MP0009333_abnormal_splenocyte_physiolog0.76586752
130MP0005389_reproductive_system_phenotype0.76381750
131MP0004134_abnormal_chest_morphology0.76198186
132MP0002735_abnormal_chemical_nociception0.75875150
133MP0002166_altered_tumor_susceptibility0.75849164
134MP0002148_abnormal_hypersensitivity_rea0.75808173
135MP0003183_abnormal_peptide_metabolism0.75205544
136MP0001851_eye_inflammation0.73794718
137MP0001958_emphysema0.73537565
138MP0010307_abnormal_tumor_latency0.73422416
139MP0005623_abnormal_meninges_morphology0.73353518
140MP0000689_abnormal_spleen_morphology0.72283896
141MP0000371_diluted_coat_color0.72122805
142MP0004043_abnormal_pH_regulation0.71688174
143MP0001845_abnormal_inflammatory_respons0.71455245
144MP0002405_respiratory_system_inflammati0.71430402
145MP0003077_abnormal_cell_cycle0.71417034
146MP0005330_cardiomyopathy0.71062868
147MP0001545_abnormal_hematopoietic_system0.69810082
148MP0005397_hematopoietic_system_phenotyp0.69810082
149MP0002722_abnormal_immune_system0.69672168
150MP0008469_abnormal_protein_level0.69584473
151MP0000747_muscle_weakness0.69361938
152MP0001191_abnormal_skin_condition0.68910325
153MP0009931_abnormal_skin_appearance0.68699941
154MP0002736_abnormal_nociception_after0.67938792
155MP0002106_abnormal_muscle_physiology0.66971628
156MP0001324_abnormal_eye_pigmentation0.66390947
157MP0010630_abnormal_cardiac_muscle0.66252672
158MP0000490_abnormal_crypts_of0.65549331
159MP0002067_abnormal_sensory_capabilities0.65347287
160MP0002060_abnormal_skin_morphology0.65218143
161MP0005248_abnormal_Harderian_gland0.64737298
162MP0003315_abnormal_perineum_morphology0.63579094
163MP0006138_congestive_heart_failure0.63256037
164MP0005085_abnormal_gallbladder_physiolo0.62321385
165MP0002882_abnormal_neuron_morphology0.61634384
166MP0000579_abnormal_nail_morphology0.61599874
167MP0002972_abnormal_cardiac_muscle0.61313192
168MP0000858_altered_metastatic_potential0.60985294
169MP0002572_abnormal_emotion/affect_behav0.58019726
170MP0001614_abnormal_blood_vessel0.57780317
171MP0000427_abnormal_hair_cycle0.57566712
172MP0002128_abnormal_blood_circulation0.56932622
173MP0001915_intracranial_hemorrhage0.56197706
174MP0000733_abnormal_muscle_development0.55963177
175MP0005023_abnormal_wound_healing0.53832722
176MP0002925_abnormal_cardiovascular_devel0.53604333
177MP0005369_muscle_phenotype0.53598845
178MP0002272_abnormal_nervous_system0.52227658
179MP0008872_abnormal_physiological_respon0.51894756
180MP0003861_abnormal_nervous_system0.50411286
181MP0000383_abnormal_hair_follicle0.50172828
182MP0000534_abnormal_ureter_morphology0.48820301
183MP0000681_abnormal_thyroid_gland0.48364744
184MP0005670_abnormal_white_adipose0.48323165
185MP0000432_abnormal_head_morphology0.47555839
186MP0003567_abnormal_fetal_cardiomyocyte0.47472244
187MP0002069_abnormal_eating/drinking_beha0.46922909
188MP0005253_abnormal_eye_physiology0.46030313

Predicted human phenotypes

RankGene SetZ-score
1Cervical subluxation (HP:0003308)8.48534076
2Overgrowth (HP:0001548)7.55612698
3Vacuolated lymphocytes (HP:0001922)6.84462374
4Abnormality of dental color (HP:0011073)6.84267414
5Ulnar deviation of the wrist (HP:0003049)6.81233242
6Aplasia/Hypoplasia of the vertebrae (HP:0008515)6.45910508
7Vertebral hypoplasia (HP:0008417)6.45910508
8Testicular atrophy (HP:0000029)5.97892018
9Dyschromatopsia (HP:0007641)5.95563873
10Rib fusion (HP:0000902)5.86384095
11Neoplasm of the adrenal cortex (HP:0100641)5.54879806
12Hemorrhage of the eye (HP:0011885)5.32854168
13Attenuation of retinal blood vessels (HP:0007843)5.16602321
14Rectal fistula (HP:0100590)5.14708268
15Rectovaginal fistula (HP:0000143)5.14708268
16Abnormality of calcium-phosphate metabolism (HP:0100530)5.14461179
17Thin bony cortex (HP:0002753)4.98125532
18Intestinal fistula (HP:0100819)4.97959075
19Growth hormone excess (HP:0000845)4.96950720
20Mesangial abnormality (HP:0001966)4.94484972
21Upper limb muscle weakness (HP:0003484)4.90754824
22Amelogenesis imperfecta (HP:0000705)4.89812901
23Joint hemorrhage (HP:0005261)4.86816335
24Flared iliac wings (HP:0002869)4.78742550
25Vaginal fistula (HP:0004320)4.72187629
26Back pain (HP:0003418)4.66836385
27Poikiloderma (HP:0001029)4.61014836
28Facial diplegia (HP:0001349)4.60227196
29Prolonged partial thromboplastin time (HP:0003645)4.50361555
30Annular pancreas (HP:0001734)4.42478079
31Choroideremia (HP:0001139)4.39842043
32Facial hemangioma (HP:0000329)4.30296878
33Beaking of vertebral bodies (HP:0004568)4.20107483
34Abnormality of the intrinsic pathway (HP:0010989)4.18522423
35Popliteal pterygium (HP:0009756)4.15365452
36Abnormality of the parathyroid morphology (HP:0011766)4.10638477
37Akinesia (HP:0002304)4.08005313
38Ulnar bowing (HP:0003031)3.99726031
39Abnormality of renal resorption (HP:0011038)3.88730341
40Short 1st metacarpal (HP:0010034)3.69987549
41Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.69987549
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.67501404
43Urinary glycosaminoglycan excretion (HP:0003541)3.62832674
44Mucopolysacchariduria (HP:0008155)3.62832674
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.62407708
46Pelvic girdle muscle weakness (HP:0003749)3.58564860
47Increased hepatocellular lipid droplets (HP:0006565)3.55342693
48Aplasia of the musculature (HP:0100854)3.54756561
49Hypoplasia of the odontoid process (HP:0003311)3.52607879
50Shoulder girdle muscle weakness (HP:0003547)3.51697002
51Disproportionate short-trunk short stature (HP:0003521)3.49747600
52Widely spaced teeth (HP:0000687)3.49134411
53Renal Fanconi syndrome (HP:0001994)3.47338959
54Abnormality of endocrine pancreas physiology (HP:0012093)3.42999789
55Abnormality of the pancreatic islet cells (HP:0006476)3.42999789
56Lipid accumulation in hepatocytes (HP:0006561)3.42702365
57Limb-girdle muscle atrophy (HP:0003797)3.39548892
58Anteriorly placed anus (HP:0001545)3.37222580
59Enlarged epiphyses (HP:0010580)3.33880026
60Squamous cell carcinoma (HP:0002860)3.32750075
61Scapular winging (HP:0003691)3.32048218
62Abnormality of mucopolysaccharide metabolism (HP:0011020)3.29915916
63Abnormality of polysaccharide metabolism (HP:0011012)3.29915916
64Abnormality of glycosaminoglycan metabolism (HP:0004371)3.29915916
65Abnormality of the dental pulp (HP:0006479)3.29282205
66Delayed epiphyseal ossification (HP:0002663)3.28088450
67Congenital stationary night blindness (HP:0007642)3.27506564
68Decreased electroretinogram (ERG) amplitude (HP:0000654)3.27167599
69Myokymia (HP:0002411)3.25847210
70Abnormality of the 1st metacarpal (HP:0010009)3.21785270
71Difficulty climbing stairs (HP:0003551)3.19207436
72Hypercortisolism (HP:0001578)3.18315908
73Abnormality of the hip-girdle musculature (HP:0001445)3.17106884
74Abnormality of the musculature of the pelvis (HP:0001469)3.17106884
75Decreased central vision (HP:0007663)3.13666746
76Bony spicule pigmentary retinopathy (HP:0007737)3.13092879
77Fetal akinesia sequence (HP:0001989)3.11801577
78Hypoalbuminemia (HP:0003073)3.11269614
79Abnormal albumin level (HP:0012116)3.11269614
80Turricephaly (HP:0000262)3.10653801
81Capillary hemangiomas (HP:0005306)3.08827353
82Exertional dyspnea (HP:0002875)3.08180770
83Abnormality of the common coagulation pathway (HP:0010990)3.05949826
84Gingival overgrowth (HP:0000212)3.05468272
85Polyuria (HP:0000103)3.04532212
86Abnormality of the odontoid process (HP:0003310)3.03779261
87Short chin (HP:0000331)2.98575021
88Rimmed vacuoles (HP:0003805)2.97280043
89Abnormality of macrophages (HP:0004311)2.95124137
90Ovoid vertebral bodies (HP:0003300)2.93255241
91Abnormality of the costochondral junction (HP:0000919)2.90867363
92Abnormality of placental membranes (HP:0011409)2.90422412
93Amniotic constriction ring (HP:0009775)2.90422412
94Atrioventricular block (HP:0001678)2.83666715
95Abnormal urine output (HP:0012590)2.80282275
96Coronal craniosynostosis (HP:0004440)2.79305854
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.75483724
98Severe short stature (HP:0003510)2.75263174
99Patellar aplasia (HP:0006443)2.74192327
100Chorioretinal atrophy (HP:0000533)2.74167484
101Myotonia (HP:0002486)2.73293278
102Hypophosphatemic rickets (HP:0004912)2.66748707
103Widely patent fontanelles and sutures (HP:0004492)2.66635062
104Abnormal sex determination (HP:0012244)2.66487705
105Sex reversal (HP:0012245)2.66487705
106Fused cervical vertebrae (HP:0002949)2.64583674
107Generalized myoclonic seizures (HP:0002123)2.58528114
108Aortic valve stenosis (HP:0001650)2.57356862
109Hyperparathyroidism (HP:0000843)2.55628067
110Aplasia/Hypoplasia of the patella (HP:0006498)2.54430885
111Zonular cataract (HP:0010920)2.54177991
112Abnormal auditory evoked potentials (HP:0006958)2.52738964
113Increased intramyocellular lipid droplets (HP:0012240)2.49731692
114Increased muscle lipid content (HP:0009058)2.48647670
115Cheilitis (HP:0100825)2.47570520
116Exocrine pancreatic insufficiency (HP:0001738)2.41468108
117Neonatal respiratory distress (HP:0002643)2.40937624
118Progressive neurologic deterioration (HP:0002344)2.39884117
119Premature graying of hair (HP:0002216)2.37940054
120Basal cell carcinoma (HP:0002671)2.37795992
121Mask-like facies (HP:0000298)2.34593645
122Respiratory difficulties (HP:0002880)2.33459180
123Abnormality of renal excretion (HP:0011036)2.32993471
124Shallow orbits (HP:0000586)2.31722980
125Gastrointestinal infarctions (HP:0005244)2.30140669
126Bowing of the arm (HP:0006488)2.28367811
127Bowed forearm bones (HP:0003956)2.28367811
128Abnormality of the hepatic vasculature (HP:0006707)2.28293241
129Neonatal onset (HP:0003623)2.24538003
130Absent thumb (HP:0009777)2.24390117
131Neoplasm of the adrenal gland (HP:0100631)2.21964234
132Flat occiput (HP:0005469)2.20924551
133Vitreoretinal degeneration (HP:0000655)2.20814589
134Short humerus (HP:0005792)2.20246173
135Chronic mucocutaneous candidiasis (HP:0002728)2.20092808
136Recurrent cutaneous fungal infections (HP:0011370)2.20092808
137Short phalanx of the thumb (HP:0009660)2.19512841
138Nephrocalcinosis (HP:0000121)2.19340126
139Anosmia (HP:0000458)2.15756517
140Abnormal epiphyseal ossification (HP:0010656)2.14505934
141Limb-girdle muscle weakness (HP:0003325)2.14002676
142Hyperpituitarism (HP:0010514)2.13365402
143Aplasia/Hypoplasia involving the musculature (HP:0001460)2.11978236
144Abnormal urine phosphate concentration (HP:0012599)2.11627905
145Malignant hyperthermia (HP:0002047)2.11233991
146Spinal rigidity (HP:0003306)2.10762011
147Acute necrotizing encephalopathy (HP:0006965)2.08177460
148Increased number of teeth (HP:0011069)2.08151178
149Coxa valga (HP:0002673)2.06719045
150Hallux valgus (HP:0001822)2.06247670
151Restrictive lung disease (HP:0002091)2.03809887
152Long clavicles (HP:0000890)2.02365389
153Aplasia/Hypoplasia involving the vertebral column (HP:0008518)2.01189380
154Proximal amyotrophy (HP:0007126)2.00336653
155Onion bulb formation (HP:0003383)1.98070658
156Aplasia/hypoplasia of the humerus (HP:0006507)1.97416041
157Cystic hygroma (HP:0000476)1.97291642
158Macular degeneration (HP:0000608)1.96619908
159Multiple enchondromatosis (HP:0005701)1.96268470
160Narrow nasal bridge (HP:0000446)1.95842760
161Joint stiffness (HP:0001387)1.93448098
162Multiple lipomas (HP:0001012)1.93290152
163Pustule (HP:0200039)1.90894696
164Deviation of the hallux (HP:0010051)1.89682656
165Severe Myopia (HP:0011003)1.89048660
166Abnormality of the shoulder girdle musculature (HP:0001435)1.88394475
167Decreased circulating renin level (HP:0003351)1.87555899
168Ankle contracture (HP:0006466)1.86221783
169Epiphyseal stippling (HP:0010655)1.85929802
170Thin ribs (HP:0000883)1.85884576
171Epistaxis (HP:0000421)1.84857538
172Abnormal mitochondria in muscle tissue (HP:0008316)1.83989122
173Polydipsia (HP:0001959)1.83444827
174Abnormal drinking behavior (HP:0030082)1.83444827
175Difficulty walking (HP:0002355)1.80656991
176Choanal stenosis (HP:0000452)1.80630727
177Premature rupture of membranes (HP:0001788)1.80248969
178Peripheral demyelination (HP:0011096)1.79853180
179Abnormality of subcutaneous fat tissue (HP:0001001)1.79580545
180Progressive macrocephaly (HP:0004481)1.76759541
181Fasciculations (HP:0002380)1.74176883
182Termporal pattern (HP:0011008)1.73668067
183Insidious onset (HP:0003587)1.73668067
184Short hallux (HP:0010109)1.72689448
185Sensory axonal neuropathy (HP:0003390)1.70451687
186Aqueductal stenosis (HP:0002410)1.69587807
187Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69179173
188Glossoptosis (HP:0000162)1.68583234
189Conjugated hyperbilirubinemia (HP:0002908)1.66128933
190Abnormality of the acetabulum (HP:0003170)1.62226259
191Acute encephalopathy (HP:0006846)1.60758316
192Adenoma sebaceum (HP:0009720)1.60158259
193Angiofibromas (HP:0010615)1.60158259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.97791785
2MAP3K33.38313130
3WNK43.23142407
4ERBB22.76721321
5MAP2K72.73728096
6PRKD32.52244921
7MAP2K42.49690968
8EPHB12.48837441
9MUSK2.46222347
10ZAP702.39035182
11MAP3K42.33805071
12MAP2K32.32995215
13MAP4K12.19066809
14MAP2K22.16200912
15MAPK72.12528199
16ACVR1B2.06921066
17CCNB112.2422710
18TLK11.87982378
19IRAK21.66204236
20DYRK1A1.63521544
21TRPM71.63071565
22TRIB31.59705545
23WNK11.45793456
24IRAK41.41906315
25CDK61.40016973
26NME11.35364895
27MAPK41.34172793
28INSRR1.31145420
29PDPK11.29456361
30PTK61.29010701
31CDK121.27527569
32CDK41.26014775
33PRPF4B1.25505586
34MKNK21.23578059
35RIPK41.22863931
36BTK1.22344007
37TESK21.21374273
38SIK11.20304952
39DYRK1B1.18981732
40TBK11.18011498
41TAOK31.17557590
42IKBKE1.06836683
43MST1R1.06014281
44SYK1.03459230
45MAP3K101.02806033
46SIK21.02705658
47EPHB21.00527823
48PIK3CG0.97122941
49ADRBK10.95841258
50SIK30.94914840
51FES0.93485157
52JAK30.92636035
53SGK20.92534199
54PTK2B0.92371164
55ICK0.92324505
56NME20.91755277
57DMPK0.88924514
58LYN0.88173944
59BMX0.88045961
60MAPK110.87477769
61ADRBK20.86744668
62CAMK1D0.86688910
63GSK3A0.85252708
64MAPK120.84485539
65RET0.83237216
66ITK0.81139258
67MAPK90.78132846
68GRK50.77868446
69CAMKK20.77862524
70SGK2230.77493671
71SGK4940.77493671
72MAP3K70.76472388
73CAMK1G0.75566621
74PRKD20.73368651
75TRIM280.72738138
76NEK90.72002083
77RPS6KA20.70882349
78MARK20.69962897
79BMPR20.69865680
80NTRK20.68970062
81MAP3K20.65747258
82CSF1R0.65633143
83TXK0.65597829
84ERN10.65496865
85NLK0.63794298
86MKNK10.62729070
87RPS6KA60.62462887
88HCK0.62162734
89OXSR10.61857383
90PAK30.60785217
91LCK0.60113473
92MELK0.59896362
93ZAK0.58636777
94TEC0.58624687
95EPHA20.58179512
96CAMK40.58049826
97TGFBR20.57329815
98MARK10.57103804
99SGK30.56717232
100TYK20.56503593
101TTN0.55415271
102UHMK10.54939576
103PTK20.54323481
104RPS6KL10.53815381
105RPS6KC10.53815381
106PAK40.53249164
107MAP3K130.52810068
108PRKD10.52004034
109KIT0.51942265
110MAPKAPK30.51524118
111PDK10.51087492
112EPHA30.50554656
113MTOR0.48916066
114STK390.48538626
115ALK0.48477357
116STK110.48432177
117FGFR40.46518503
118CDK150.46418038
119SCYL20.45908149
120FLT30.45188359
121IKBKB0.44791545
122CDK180.42979753
123CHUK0.42854581
124RPS6KA50.42725452
125MAPK80.42626863
126CSK0.41598723
127CDC42BPA0.40795704
128MAP3K10.39997429
129CDK11A0.39642976
130GRK70.39466966
131CHEK20.39267656
132ABL10.38504557
133STK100.37901901
134PKN20.37187343
135AKT30.34689189
136MAP2K10.34533387
137FGFR20.34076254
138IRAK30.33986663
139IRAK10.32874721
140JAK10.32596752
141AURKA0.31969672
142CDK50.31408305
143MAP3K110.31121900
144HIPK20.31114783
145FYN0.31065346
146FGFR30.30393800
147GRK60.30366834
148IGF1R0.29047574
149CAMK10.28565892
150TIE10.26557811
151RIPK10.25549761
152MAP2K60.25513109
153PAK60.25277178
154CSNK1A10.24642291
155GSK3B0.24182519
156PAK20.23791714
157ERBB30.22578619
158JAK20.21173060
159MAPK100.20684716
160PAK10.19858881
161MAPK10.19851027
162MAP3K140.19749629
163LRRK20.19739927
164NTRK30.19459689
165NTRK10.18730260
166MAPKAPK20.17849161
167ATM0.17414086
168MAPK150.16627631
169MOS0.16120886
170CAMKK10.16024681
171FRK0.15993604
172PKN10.15430126
173CSNK1G10.15392757

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001305.90417487
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006045.73225854
3Glycosaminoglycan degradation_Homo sapiens_hsa005314.78033429
4Other glycan degradation_Homo sapiens_hsa005114.64301957
5Sulfur relay system_Homo sapiens_hsa041223.13945776
6Sulfur metabolism_Homo sapiens_hsa009203.03388832
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.52958121
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.38024427
9Nitrogen metabolism_Homo sapiens_hsa009102.29327304
10Wnt signaling pathway_Homo sapiens_hsa043102.19844416
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15521278
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.11775684
13Galactose metabolism_Homo sapiens_hsa000522.07648750
14Fructose and mannose metabolism_Homo sapiens_hsa000511.94188013
15Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.78467581
16Sphingolipid metabolism_Homo sapiens_hsa006001.71674557
17Dilated cardiomyopathy_Homo sapiens_hsa054141.69738044
18Circadian rhythm_Homo sapiens_hsa047101.67207187
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.55606678
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.36213745
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31501866
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30126901
23ECM-receptor interaction_Homo sapiens_hsa045121.29653566
24mTOR signaling pathway_Homo sapiens_hsa041501.27797214
25Viral myocarditis_Homo sapiens_hsa054161.27763028
26Inositol phosphate metabolism_Homo sapiens_hsa005621.27123486
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24181246
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23067034
29Hematopoietic cell lineage_Homo sapiens_hsa046401.22122044
30Fanconi anemia pathway_Homo sapiens_hsa034601.20942867
31Vitamin digestion and absorption_Homo sapiens_hsa049771.20647720
32Adherens junction_Homo sapiens_hsa045201.15501161
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11476546
34Prion diseases_Homo sapiens_hsa050201.10883791
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10860036
36Staphylococcus aureus infection_Homo sapiens_hsa051501.10734408
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08377275
38Oxytocin signaling pathway_Homo sapiens_hsa049211.07277844
39Tuberculosis_Homo sapiens_hsa051521.05697615
40Pertussis_Homo sapiens_hsa051331.04310566
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03349577
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03287622
43Non-small cell lung cancer_Homo sapiens_hsa052231.00893523
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00066527
45Lysosome_Homo sapiens_hsa041421.00039351
46Amphetamine addiction_Homo sapiens_hsa050310.99896571
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98554992
48Axon guidance_Homo sapiens_hsa043600.98301453
49PPAR signaling pathway_Homo sapiens_hsa033200.98198331
50Leishmaniasis_Homo sapiens_hsa051400.97878079
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94478242
52Nicotine addiction_Homo sapiens_hsa050330.94191299
53Primary immunodeficiency_Homo sapiens_hsa053400.93631461
54Hedgehog signaling pathway_Homo sapiens_hsa043400.93345220
55Acute myeloid leukemia_Homo sapiens_hsa052210.92273626
56Insulin resistance_Homo sapiens_hsa049310.92188825
57Circadian entrainment_Homo sapiens_hsa047130.91791473
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91518111
59Thyroid hormone synthesis_Homo sapiens_hsa049180.91154042
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90327152
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89945747
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.89810367
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89293599
64Asthma_Homo sapiens_hsa053100.88716965
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88618208
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.88391383
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87414131
68Influenza A_Homo sapiens_hsa051640.86562413
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86361323
70VEGF signaling pathway_Homo sapiens_hsa043700.86108745
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86073906
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.85828045
73Graft-versus-host disease_Homo sapiens_hsa053320.85679135
74Ether lipid metabolism_Homo sapiens_hsa005650.85388147
75Systemic lupus erythematosus_Homo sapiens_hsa053220.84788731
76Allograft rejection_Homo sapiens_hsa053300.82596646
77Complement and coagulation cascades_Homo sapiens_hsa046100.82273134
78Arginine biosynthesis_Homo sapiens_hsa002200.82243786
79Focal adhesion_Homo sapiens_hsa045100.81529057
80Bladder cancer_Homo sapiens_hsa052190.80459431
81* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80445332
82Hippo signaling pathway_Homo sapiens_hsa043900.78592114
83Autoimmune thyroid disease_Homo sapiens_hsa053200.77135492
84Melanogenesis_Homo sapiens_hsa049160.77085910
85Insulin secretion_Homo sapiens_hsa049110.76664503
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75672736
87Type II diabetes mellitus_Homo sapiens_hsa049300.75029743
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74805152
89Salivary secretion_Homo sapiens_hsa049700.74597279
90Dopaminergic synapse_Homo sapiens_hsa047280.74061525
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.73900544
92Gastric acid secretion_Homo sapiens_hsa049710.72677952
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72445206
94Taste transduction_Homo sapiens_hsa047420.72407934
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72005399
96Amoebiasis_Homo sapiens_hsa051460.71205772
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70150253
98cAMP signaling pathway_Homo sapiens_hsa040240.68856539
99Vitamin B6 metabolism_Homo sapiens_hsa007500.68795213
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68535667
101Glutamatergic synapse_Homo sapiens_hsa047240.67498271
102African trypanosomiasis_Homo sapiens_hsa051430.67489686
103Colorectal cancer_Homo sapiens_hsa052100.67014307
104Renin secretion_Homo sapiens_hsa049240.66907102
105Gap junction_Homo sapiens_hsa045400.66764315
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.66743142
107Bile secretion_Homo sapiens_hsa049760.66595273
108TNF signaling pathway_Homo sapiens_hsa046680.65361951
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64950429
110Cholinergic synapse_Homo sapiens_hsa047250.64205778
111Calcium signaling pathway_Homo sapiens_hsa040200.63360277
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63177339
113Salmonella infection_Homo sapiens_hsa051320.62950201
114Alcoholism_Homo sapiens_hsa050340.62629556
115Dorso-ventral axis formation_Homo sapiens_hsa043200.62585173
116MAPK signaling pathway_Homo sapiens_hsa040100.61595695
117GABAergic synapse_Homo sapiens_hsa047270.61545046
118Hepatitis C_Homo sapiens_hsa051600.61388205
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61096355
120Basal cell carcinoma_Homo sapiens_hsa052170.60751096
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60548831
122Long-term potentiation_Homo sapiens_hsa047200.60520968
123Notch signaling pathway_Homo sapiens_hsa043300.60310592
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59028485
125Hepatitis B_Homo sapiens_hsa051610.58919792
126Chronic myeloid leukemia_Homo sapiens_hsa052200.58453560
127Protein digestion and absorption_Homo sapiens_hsa049740.56562308
128Osteoclast differentiation_Homo sapiens_hsa043800.55524801
129Proteoglycans in cancer_Homo sapiens_hsa052050.54390450
130Endocytosis_Homo sapiens_hsa041440.54354692
131Choline metabolism in cancer_Homo sapiens_hsa052310.51863517
132Ovarian steroidogenesis_Homo sapiens_hsa049130.51481635
133ErbB signaling pathway_Homo sapiens_hsa040120.51177139
134MicroRNAs in cancer_Homo sapiens_hsa052060.50548611
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50360153
136Cocaine addiction_Homo sapiens_hsa050300.49911541
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49896701
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.49205198
139Measles_Homo sapiens_hsa051620.48522143
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.48447383
141Pancreatic cancer_Homo sapiens_hsa052120.48421474
142Selenocompound metabolism_Homo sapiens_hsa004500.47558309
143Phototransduction_Homo sapiens_hsa047440.47278720
144FoxO signaling pathway_Homo sapiens_hsa040680.47206831
145Glucagon signaling pathway_Homo sapiens_hsa049220.47049668
146Small cell lung cancer_Homo sapiens_hsa052220.45850537
147B cell receptor signaling pathway_Homo sapiens_hsa046620.45171800
148Platelet activation_Homo sapiens_hsa046110.43240152
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.43133909
150Herpes simplex infection_Homo sapiens_hsa051680.41882591
151T cell receptor signaling pathway_Homo sapiens_hsa046600.41761286
152Pathways in cancer_Homo sapiens_hsa052000.40631776
153Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40307849
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39982366
155Apoptosis_Homo sapiens_hsa042100.39159113
156Chemokine signaling pathway_Homo sapiens_hsa040620.38382841
157Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38273513
158Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38165059
159Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37934241
160Morphine addiction_Homo sapiens_hsa050320.37352429
161Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36948097
162Sphingolipid signaling pathway_Homo sapiens_hsa040710.36771107
163Long-term depression_Homo sapiens_hsa047300.35581007
164Toxoplasmosis_Homo sapiens_hsa051450.35045312
165Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34271960
166Lysine degradation_Homo sapiens_hsa003100.34138256
167Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33094169
168Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32801812
169GnRH signaling pathway_Homo sapiens_hsa049120.32711926
170Prolactin signaling pathway_Homo sapiens_hsa049170.32235927
171Maturity onset diabetes of the young_Homo sapiens_hsa049500.31901099
172Type I diabetes mellitus_Homo sapiens_hsa049400.31848094
173Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31478868
174Butanoate metabolism_Homo sapiens_hsa006500.30861877
175Endometrial cancer_Homo sapiens_hsa052130.30800612
176Viral carcinogenesis_Homo sapiens_hsa052030.30318195
177Renal cell carcinoma_Homo sapiens_hsa052110.27619558
178Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26285517

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