Rank | Gene Set | Z-score |
---|---|---|
1 | actin-mediated cell contraction (GO:0070252) | 7.54808142 |
2 | skeletal muscle contraction (GO:0003009) | 6.60729581 |
3 | actin filament-based movement (GO:0030048) | 5.64287301 |
4 | regulation of synapse structural plasticity (GO:0051823) | 5.32952028 |
5 | response to muscle activity (GO:0014850) | 5.03251949 |
6 | striatum development (GO:0021756) | 5.02458138 |
7 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 4.99305842 |
8 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 4.98355086 |
9 | melanin biosynthetic process (GO:0042438) | 4.90736648 |
10 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.86657221 |
11 | prepulse inhibition (GO:0060134) | 4.73655694 |
12 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 4.69951964 |
13 | synaptic transmission, dopaminergic (GO:0001963) | 4.51028633 |
14 | regulation of membrane repolarization (GO:0060306) | 4.47104210 |
15 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 4.43116576 |
16 | melanin metabolic process (GO:0006582) | 4.42714544 |
17 | skeletal muscle fiber development (GO:0048741) | 4.42098815 |
18 | retinal rod cell development (GO:0046548) | 4.39324240 |
19 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 4.39019884 |
20 | sarcomere organization (GO:0045214) | 4.32108858 |
21 | creatine metabolic process (GO:0006600) | 4.23534943 |
22 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 4.22746388 |
23 | myotube cell development (GO:0014904) | 4.19386166 |
24 | muscle contraction (GO:0006936) | 4.19091182 |
25 | tricarboxylic acid cycle (GO:0006099) | 4.15214641 |
26 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 4.11448956 |
27 | secondary metabolite biosynthetic process (GO:0044550) | 4.01363559 |
28 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 4.00158992 |
29 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 3.97669777 |
30 | cardiac myofibril assembly (GO:0055003) | 3.96672581 |
31 | cardiac muscle contraction (GO:0060048) | 3.96084033 |
32 | striated muscle hypertrophy (GO:0014897) | 3.92669013 |
33 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.89266638 |
34 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 3.86950881 |
35 | muscle fiber development (GO:0048747) | 3.85781290 |
36 | glycogen catabolic process (GO:0005980) | 3.83689856 |
37 | muscle system process (GO:0003012) | 3.78142042 |
38 | myofibril assembly (GO:0030239) | 3.72506032 |
39 | adenosine receptor signaling pathway (GO:0001973) | 3.71574824 |
40 | behavioral response to cocaine (GO:0048148) | 3.68785990 |
41 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.67543850 |
42 | adult heart development (GO:0007512) | 3.66179675 |
43 | auditory behavior (GO:0031223) | 3.61817910 |
44 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 3.58349972 |
45 | muscle cell cellular homeostasis (GO:0046716) | 3.58200946 |
46 | skeletal muscle adaptation (GO:0043501) | 3.57558498 |
47 | cAMP catabolic process (GO:0006198) | 3.56935665 |
48 | regulation of skeletal muscle contraction (GO:0014819) | 3.56027147 |
49 | glucan catabolic process (GO:0009251) | 3.55483501 |
50 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.55407166 |
51 | cardiac muscle cell development (GO:0055013) | 3.55140359 |
52 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 3.53615150 |
53 | dopamine receptor signaling pathway (GO:0007212) | 3.52718119 |
54 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 3.52106922 |
55 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.51820444 |
56 | regulation of striated muscle contraction (GO:0006942) | 3.47673085 |
57 | regulation of cell communication by electrical coupling (GO:0010649) | 3.46523662 |
58 | carnitine shuttle (GO:0006853) | 3.45876220 |
59 | actin-myosin filament sliding (GO:0033275) | 3.45837132 |
60 | muscle filament sliding (GO:0030049) | 3.45837132 |
61 | response to amphetamine (GO:0001975) | 3.45037341 |
62 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 3.44995787 |
63 | plasma membrane repair (GO:0001778) | 3.39051722 |
64 | vocalization behavior (GO:0071625) | 3.38990539 |
65 | cell communication involved in cardiac conduction (GO:0086065) | 3.38571181 |
66 | striated muscle contraction (GO:0006941) | 3.37094872 |
67 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.36878089 |
68 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.36878089 |
69 | succinate metabolic process (GO:0006105) | 3.36539798 |
70 | gluconeogenesis (GO:0006094) | 3.36482884 |
71 | muscle hypertrophy (GO:0014896) | 3.36470968 |
72 | cardiac conduction (GO:0061337) | 3.35546704 |
73 | glucan biosynthetic process (GO:0009250) | 3.35338484 |
74 | glycogen biosynthetic process (GO:0005978) | 3.35338484 |
75 | striated muscle adaptation (GO:0014888) | 3.34886563 |
76 | regulation of female receptivity (GO:0045924) | 3.34086916 |
77 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 3.34082877 |
78 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.31810802 |
79 | * skeletal muscle tissue development (GO:0007519) | 3.30670284 |
80 | fructose metabolic process (GO:0006000) | 3.30491342 |
81 | cellular polysaccharide catabolic process (GO:0044247) | 3.28923490 |
82 | regulation of glucokinase activity (GO:0033131) | 3.28709520 |
83 | regulation of hexokinase activity (GO:1903299) | 3.28709520 |
84 | response to inactivity (GO:0014854) | 3.28075809 |
85 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.26454099 |
86 | relaxation of muscle (GO:0090075) | 3.25620478 |
87 | cardiac cell development (GO:0055006) | 3.25055695 |
88 | myotube differentiation (GO:0014902) | 3.24951202 |
89 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.24157976 |
90 | regulation of heart rate by cardiac conduction (GO:0086091) | 3.23061572 |
91 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.21791790 |
92 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.21694265 |
93 | detection of calcium ion (GO:0005513) | 3.21432143 |
94 | neuromuscular synaptic transmission (GO:0007274) | 3.20784032 |
95 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.20519476 |
96 | cardiac muscle cell action potential (GO:0086001) | 3.20210613 |
97 | regulation of relaxation of muscle (GO:1901077) | 3.20197787 |
98 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.19399256 |
99 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.19399256 |
100 | regulation of actin filament-based movement (GO:1903115) | 3.17987866 |
101 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.17339132 |
102 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.17241625 |
103 | activation of protein kinase A activity (GO:0034199) | 3.15218119 |
104 | striated muscle cell development (GO:0055002) | 3.14997857 |
105 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.14517040 |
106 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.13732809 |
107 | female mating behavior (GO:0060180) | 3.12827446 |
108 | regulation of glutamate secretion (GO:0014048) | 3.12387069 |
109 | muscle cell fate commitment (GO:0042693) | 3.10982046 |
110 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 3.10364128 |
111 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 3.10364128 |
112 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.10340904 |
113 | NADH metabolic process (GO:0006734) | 3.09337337 |
114 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.09005110 |
115 | cyclic nucleotide catabolic process (GO:0009214) | 3.07902042 |
116 | fatty acid transmembrane transport (GO:1902001) | 3.07854010 |
117 | muscle tissue morphogenesis (GO:0060415) | 3.07426310 |
118 | cell communication by electrical coupling (GO:0010644) | 3.06918118 |
119 | peristalsis (GO:0030432) | 3.06030989 |
120 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.05430197 |
121 | regulation of cofactor metabolic process (GO:0051193) | 3.03212330 |
122 | regulation of coenzyme metabolic process (GO:0051196) | 3.03212330 |
123 | muscle structure development (GO:0061061) | 3.01828254 |
124 | regulation of the force of heart contraction (GO:0002026) | 3.01804720 |
125 | relaxation of cardiac muscle (GO:0055119) | 3.01477755 |
126 | negative regulation of protein localization to cell surface (GO:2000009) | 3.00935022 |
127 | response to epinephrine (GO:0071871) | 3.00785568 |
128 | response to caffeine (GO:0031000) | 3.00701534 |
129 | muscle organ development (GO:0007517) | 3.00551316 |
130 | skeletal muscle tissue regeneration (GO:0043403) | 3.00404465 |
131 | regulation of skeletal muscle cell differentiation (GO:2001014) | 2.99510683 |
132 | regulation of protein kinase A signaling (GO:0010738) | 2.98673881 |
133 | melanocyte differentiation (GO:0030318) | 2.98318095 |
134 | locomotory exploration behavior (GO:0035641) | 2.97973180 |
135 | potassium ion export (GO:0071435) | 2.97735418 |
136 | synaptic vesicle maturation (GO:0016188) | 2.96881656 |
137 | negative regulation of potassium ion transport (GO:0043267) | 2.96291642 |
138 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.95887122 |
139 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.94055045 |
140 | polysaccharide catabolic process (GO:0000272) | 2.93926857 |
141 | actomyosin structure organization (GO:0031032) | 2.93764974 |
142 | myoblast fusion (GO:0007520) | 2.93389345 |
143 | hexose biosynthetic process (GO:0019319) | 2.93151634 |
144 | cardiac muscle adaptation (GO:0014887) | 2.92555322 |
145 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 2.92555322 |
146 | muscle hypertrophy in response to stress (GO:0003299) | 2.92555322 |
147 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.91378467 |
148 | multicellular organismal signaling (GO:0035637) | 2.90723122 |
149 | cAMP metabolic process (GO:0046058) | 2.88648320 |
150 | response to auditory stimulus (GO:0010996) | 2.87498970 |
151 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.87489740 |
152 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.87489740 |
153 | regulation of cation channel activity (GO:2001257) | 2.86631502 |
154 | regulation of sarcomere organization (GO:0060297) | 2.86368798 |
155 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.84341802 |
156 | positive regulation of neurotransmitter transport (GO:0051590) | 2.84287975 |
157 | regulation of ATP catabolic process (GO:1903289) | 2.83709408 |
158 | regulation of ATPase activity (GO:0043462) | 2.83709408 |
159 | cardiac muscle hypertrophy (GO:0003300) | 2.82441305 |
160 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.82350506 |
161 | positive regulation of renal sodium excretion (GO:0035815) | 2.81708369 |
162 | pigment cell differentiation (GO:0050931) | 2.81391533 |
163 | regulation of heart rate (GO:0002027) | 2.81085112 |
164 | glycogen metabolic process (GO:0005977) | 2.77691730 |
165 | cellular glucan metabolic process (GO:0006073) | 2.70526353 |
166 | glucan metabolic process (GO:0044042) | 2.70526353 |
167 | positive regulation of cation channel activity (GO:2001259) | 2.67011238 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.68200208 |
2 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 3.38116628 |
3 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 2.86947172 |
4 | * SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.83260115 |
5 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.82818481 |
6 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.82512670 |
7 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.78082301 |
8 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.58146192 |
9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.40268288 |
10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.40268288 |
11 | * SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.40011919 |
12 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.38911316 |
13 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.38172877 |
14 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.33858186 |
15 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.30170736 |
16 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.30042992 |
17 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.20945552 |
18 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.19675098 |
19 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.18414281 |
20 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.15808699 |
21 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.14946141 |
22 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.05249287 |
23 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.02204791 |
24 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.98708837 |
25 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.94121681 |
26 | * SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.92819252 |
27 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.92798953 |
28 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.90717041 |
29 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.80791053 |
30 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.76110485 |
31 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.75164182 |
32 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.74515158 |
33 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.71914003 |
34 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.71426964 |
35 | FUS_26573619_Chip-Seq_HEK293_Human | 1.62330647 |
36 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.55708901 |
37 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.53792154 |
38 | * MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.50923710 |
39 | * SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.50538037 |
40 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.49514630 |
41 | * EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.48639400 |
42 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.47932426 |
43 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.46547991 |
44 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.42741414 |
45 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.40415793 |
46 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.38826848 |
47 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.37597239 |
48 | * P53_22387025_ChIP-Seq_ESCs_Mouse | 1.35988452 |
49 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.35206213 |
50 | * TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.35031389 |
51 | * CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.33163592 |
52 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.30596073 |
53 | * NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.29166423 |
54 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.28982891 |
55 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.28982891 |
56 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.27615581 |
57 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.27615581 |
58 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.27424263 |
59 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.26968758 |
60 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.26562936 |
61 | * NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.26547810 |
62 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.26424708 |
63 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.26274285 |
64 | * CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.25181036 |
65 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.25047198 |
66 | * EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.24473062 |
67 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.23989315 |
68 | GATA1_22025678_ChIP-Seq_K562_Human | 1.23157036 |
69 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.21252959 |
70 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.19771577 |
71 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.19607805 |
72 | VDR_22108803_ChIP-Seq_LS180_Human | 1.19050613 |
73 | * E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.19048569 |
74 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.18564684 |
75 | * EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.16912396 |
76 | * OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.16015876 |
77 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.15981114 |
78 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.15924330 |
79 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.15330491 |
80 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.14640284 |
81 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.14503255 |
82 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.11796919 |
83 | * SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.11790147 |
84 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.11654503 |
85 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.11483994 |
86 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.10329584 |
87 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.10329584 |
88 | * SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.09866371 |
89 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.09651517 |
90 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08892733 |
91 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.08740641 |
92 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.08587378 |
93 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.08170444 |
94 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.07675612 |
95 | * CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.07358745 |
96 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.07288211 |
97 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.06677563 |
98 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.06217607 |
99 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.06131105 |
100 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.06129169 |
101 | * PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.06086646 |
102 | AR_19668381_ChIP-Seq_PC3_Human | 1.06040654 |
103 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05405152 |
104 | * TBL1_22424771_ChIP-Seq_293T_Human | 1.04914165 |
105 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.04460473 |
106 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.04368385 |
107 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.03434543 |
108 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.02501772 |
109 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.02225034 |
110 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.01635652 |
111 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.01602777 |
112 | * SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.00632274 |
113 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.00429826 |
114 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.00232178 |
115 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.98943877 |
116 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.95614319 |
117 | * KLF4_19829295_ChIP-Seq_ESCs_Human | 0.94836694 |
118 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.94230020 |
119 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.94165082 |
120 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.93664450 |
121 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93542710 |
122 | * SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.93515578 |
123 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.91904714 |
124 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.90328326 |
125 | KDM2B_26808549_Chip-Seq_K562_Human | 0.89839997 |
126 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.89365122 |
127 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.89334159 |
128 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.88970580 |
129 | STAT3_23295773_ChIP-Seq_U87_Human | 0.88927536 |
130 | * P300_19829295_ChIP-Seq_ESCs_Human | 0.87690298 |
131 | AR_25329375_ChIP-Seq_VCAP_Human | 0.87486298 |
132 | TCF4_23295773_ChIP-Seq_U87_Human | 0.85736521 |
133 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.84061737 |
134 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.83445953 |
135 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.82719144 |
136 | * NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.82411492 |
137 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.81670302 |
138 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.81531029 |
139 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.80807833 |
140 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80598439 |
141 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.79932264 |
142 | * BCAT_22108803_ChIP-Seq_LS180_Human | 0.79501216 |
143 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.76983029 |
144 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.76203206 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * MP0002822_catalepsy | 5.28772267 |
2 | MP0002837_dystrophic_cardiac_calcinosis | 4.61280784 |
3 | MP0000751_myopathy | 4.29801431 |
4 | MP0003646_muscle_fatigue | 4.29513997 |
5 | MP0000372_irregular_coat_pigmentation | 4.19884751 |
6 | MP0004859_abnormal_synaptic_plasticity | 3.68295136 |
7 | MP0005171_absent_coat_pigmentation | 3.57643377 |
8 | MP0004215_abnormal_myocardial_fiber | 2.99287358 |
9 | MP0001529_abnormal_vocalization | 2.82624689 |
10 | MP0000749_muscle_degeneration | 2.81723152 |
11 | MP0004084_abnormal_cardiac_muscle | 2.74754493 |
12 | MP0003136_yellow_coat_color | 2.61143888 |
13 | MP0003635_abnormal_synaptic_transmissio | 2.54063115 |
14 | * MP0004036_abnormal_muscle_relaxation | 2.48784141 |
15 | MP0004130_abnormal_muscle_cell | 2.44767965 |
16 | MP0009745_abnormal_behavioral_response | 2.41752978 |
17 | MP0003880_abnormal_central_pattern | 2.39448313 |
18 | MP0005330_cardiomyopathy | 2.39122544 |
19 | MP0003137_abnormal_impulse_conducting | 2.24992783 |
20 | MP0005408_hypopigmentation | 2.20041483 |
21 | MP0002063_abnormal_learning/memory/cond | 2.19439972 |
22 | MP0002638_abnormal_pupillary_reflex | 2.17448073 |
23 | MP0005620_abnormal_muscle_contractility | 2.09897284 |
24 | MP0004270_analgesia | 2.09664796 |
25 | MP0004145_abnormal_muscle_electrophysio | 2.08647962 |
26 | MP0004087_abnormal_muscle_fiber | 2.04531340 |
27 | MP0004085_abnormal_heartbeat | 1.89149829 |
28 | MP0002972_abnormal_cardiac_muscle | 1.87618849 |
29 | MP0002909_abnormal_adrenal_gland | 1.86454118 |
30 | MP0002106_abnormal_muscle_physiology | 1.82181939 |
31 | MP0002064_seizures | 1.79626969 |
32 | MP0005075_abnormal_melanosome_morpholog | 1.78659688 |
33 | MP0002572_abnormal_emotion/affect_behav | 1.77235211 |
34 | * MP0005386_behavior/neurological_phenoty | 1.70850507 |
35 | * MP0004924_abnormal_behavior | 1.70850507 |
36 | MP0009046_muscle_twitch | 1.70719231 |
37 | MP0001486_abnormal_startle_reflex | 1.68993025 |
38 | MP0000747_muscle_weakness | 1.67723933 |
39 | MP0002272_abnormal_nervous_system | 1.67641577 |
40 | MP0005451_abnormal_body_composition | 1.67102180 |
41 | MP0005646_abnormal_pituitary_gland | 1.65137131 |
42 | MP0002269_muscular_atrophy | 1.64636935 |
43 | MP0005670_abnormal_white_adipose | 1.63082825 |
44 | MP0006036_abnormal_mitochondrial_physio | 1.61752955 |
45 | MP0005253_abnormal_eye_physiology | 1.61600972 |
46 | MP0001968_abnormal_touch/_nociception | 1.56865696 |
47 | MP0008775_abnormal_heart_ventricle | 1.56633436 |
48 | MP0001544_abnormal_cardiovascular_syste | 1.55790394 |
49 | MP0005385_cardiovascular_system_phenoty | 1.55790394 |
50 | MP0005248_abnormal_Harderian_gland | 1.55553905 |
51 | MP0000759_abnormal_skeletal_muscle | 1.54913523 |
52 | MP0005369_muscle_phenotype | 1.53255350 |
53 | MP0004484_altered_response_of | 1.51860086 |
54 | MP0000750_abnormal_muscle_regeneration | 1.50978522 |
55 | MP0000733_abnormal_muscle_development | 1.40661753 |
56 | MP0004381_abnormal_hair_follicle | 1.39918089 |
57 | MP0005409_darkened_coat_color | 1.39525659 |
58 | MP0004233_abnormal_muscle_weight | 1.38858934 |
59 | MP0006138_congestive_heart_failure | 1.31975039 |
60 | MP0002332_abnormal_exercise_endurance | 1.28316154 |
61 | MP0002102_abnormal_ear_morphology | 1.26523110 |
62 | MP0005551_abnormal_eye_electrophysiolog | 1.25610123 |
63 | MP0005535_abnormal_body_temperature | 1.22330138 |
64 | MP0010630_abnormal_cardiac_muscle | 1.20760458 |
65 | MP0001440_abnormal_grooming_behavior | 1.18604300 |
66 | MP0005423_abnormal_somatic_nervous | 1.18296371 |
67 | MP0002938_white_spotting | 1.17898629 |
68 | MP0001324_abnormal_eye_pigmentation | 1.16380621 |
69 | MP0001984_abnormal_olfaction | 1.16040270 |
70 | MP0002734_abnormal_mechanical_nocicepti | 1.15316125 |
71 | MP0000013_abnormal_adipose_tissue | 1.14624352 |
72 | MP0005085_abnormal_gallbladder_physiolo | 1.13808160 |
73 | MP0009780_abnormal_chondrocyte_physiolo | 1.12755486 |
74 | MP0008569_lethality_at_weaning | 1.11134679 |
75 | MP0001905_abnormal_dopamine_level | 1.10019250 |
76 | MP0006035_abnormal_mitochondrial_morpho | 1.08519093 |
77 | MP0005666_abnormal_adipose_tissue | 1.07549465 |
78 | MP0000015_abnormal_ear_pigmentation | 1.05327529 |
79 | MP0001501_abnormal_sleep_pattern | 1.03215446 |
80 | MP0008874_decreased_physiological_sensi | 1.02335004 |
81 | MP0002557_abnormal_social/conspecific_i | 1.01367237 |
82 | MP0001970_abnormal_pain_threshold | 1.00907584 |
83 | MP0003221_abnormal_cardiomyocyte_apopto | 1.00162628 |
84 | MP0002067_abnormal_sensory_capabilities | 1.00047594 |
85 | MP0003633_abnormal_nervous_system | 0.98688208 |
86 | MP0003075_altered_response_to | 0.98370758 |
87 | MP0002736_abnormal_nociception_after | 0.98056586 |
88 | MP0005167_abnormal_blood-brain_barrier | 0.97723739 |
89 | MP0002095_abnormal_skin_pigmentation | 0.97489562 |
90 | MP0005187_abnormal_penis_morphology | 0.96838448 |
91 | MP0003122_maternal_imprinting | 0.96474920 |
92 | MP0002733_abnormal_thermal_nociception | 0.95627158 |
93 | MP0003690_abnormal_glial_cell | 0.95010219 |
94 | MP0000230_abnormal_systemic_arterial | 0.90737066 |
95 | MP0002066_abnormal_motor_capabilities/c | 0.90614245 |
96 | MP0002735_abnormal_chemical_nociception | 0.90440665 |
97 | MP0004043_abnormal_pH_regulation | 0.90204250 |
98 | MP0002127_abnormal_cardiovascular_syste | 0.90185146 |
99 | MP0008961_abnormal_basal_metabolism | 0.88324940 |
100 | MP0004811_abnormal_neuron_physiology | 0.88114974 |
101 | MP0000569_abnormal_digit_pigmentation | 0.85149404 |
102 | MP0004142_abnormal_muscle_tone | 0.81661979 |
103 | MP0006276_abnormal_autonomic_nervous | 0.81134471 |
104 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.80428929 |
105 | MP0006072_abnormal_retinal_apoptosis | 0.79805180 |
106 | MP0001502_abnormal_circadian_rhythm | 0.79787875 |
107 | MP0005375_adipose_tissue_phenotype | 0.79441489 |
108 | MP0000371_diluted_coat_color | 0.78778499 |
109 | MP0003011_delayed_dark_adaptation | 0.77742566 |
110 | MP0002971_abnormal_brown_adipose | 0.77212741 |
111 | MP0002078_abnormal_glucose_homeostasis | 0.76277570 |
112 | MP0003567_abnormal_fetal_cardiomyocyte | 0.75441286 |
113 | MP0002108_abnormal_muscle_morphology | 0.74625238 |
114 | MP0008872_abnormal_physiological_respon | 0.72703983 |
115 | MP0001299_abnormal_eye_distance/ | 0.70986111 |
116 | MP0002234_abnormal_pharynx_morphology | 0.70465204 |
117 | MP0003631_nervous_system_phenotype | 0.70037627 |
118 | MP0005645_abnormal_hypothalamus_physiol | 0.69735379 |
119 | MP0003329_amyloid_beta_deposits | 0.69367866 |
120 | MP0002229_neurodegeneration | 0.68550170 |
121 | MP0004510_myositis | 0.68208109 |
122 | MP0002090_abnormal_vision | 0.68103669 |
123 | MP0005266_abnormal_metabolism | 0.67186803 |
124 | MP0001177_atelectasis | 0.66818771 |
125 | MP0002877_abnormal_melanocyte_morpholog | 0.66095953 |
126 | MP0002752_abnormal_somatic_nervous | 0.66039765 |
127 | MP0003879_abnormal_hair_cell | 0.65753429 |
128 | MP0002069_abnormal_eating/drinking_beha | 0.64733776 |
129 | MP0010030_abnormal_orbit_morphology | 0.64717640 |
130 | MP0010329_abnormal_lipoprotein_level | 0.63534282 |
131 | MP0005197_abnormal_uvea_morphology | 0.62927402 |
132 | MP0002882_abnormal_neuron_morphology | 0.62431199 |
133 | MP0003283_abnormal_digestive_organ | 0.60556796 |
134 | MP0005448_abnormal_energy_balance | 0.60125937 |
135 | MP0000003_abnormal_adipose_tissue | 0.60068526 |
136 | MP0004885_abnormal_endolymph | 0.58427978 |
137 | MP0004134_abnormal_chest_morphology | 0.57532119 |
138 | MP0005391_vision/eye_phenotype | 0.57134975 |
139 | MP0005195_abnormal_posterior_eye | 0.57097429 |
140 | MP0003195_calcinosis | 0.56711043 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Nemaline bodies (HP:0003798) | 8.57730153 |
2 | Exercise-induced myalgia (HP:0003738) | 6.21391688 |
3 | Distal arthrogryposis (HP:0005684) | 5.48215735 |
4 | Sudden death (HP:0001699) | 5.43377285 |
5 | Calf muscle hypertrophy (HP:0008981) | 5.08271143 |
6 | Myokymia (HP:0002411) | 5.06192285 |
7 | Muscle hypertrophy of the lower extremities (HP:0008968) | 4.92192684 |
8 | Exercise-induced muscle cramps (HP:0003710) | 4.78951603 |
9 | Atrial fibrillation (HP:0005110) | 4.71842014 |
10 | Round ear (HP:0100830) | 4.55060899 |
11 | Primary atrial arrhythmia (HP:0001692) | 4.46722748 |
12 | Focal motor seizures (HP:0011153) | 4.40212328 |
13 | Prolonged QT interval (HP:0001657) | 4.35673528 |
14 | Myoglobinuria (HP:0002913) | 4.33914814 |
15 | Supraventricular tachycardia (HP:0004755) | 4.29098749 |
16 | Myopathic facies (HP:0002058) | 4.16741036 |
17 | Supraventricular arrhythmia (HP:0005115) | 4.16448300 |
18 | Abnormality of the calf musculature (HP:0001430) | 4.06232334 |
19 | Atrioventricular block (HP:0001678) | 4.05700132 |
20 | Bundle branch block (HP:0011710) | 3.99256191 |
21 | Posterior subcapsular cataract (HP:0007787) | 3.96858504 |
22 | Ventricular tachycardia (HP:0004756) | 3.92543333 |
23 | Heart block (HP:0012722) | 3.91141779 |
24 | Ulnar deviation of the wrist (HP:0003049) | 3.86967961 |
25 | Fetal akinesia sequence (HP:0001989) | 3.68297020 |
26 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 3.65124140 |
27 | Abnormal atrioventricular conduction (HP:0005150) | 3.61510408 |
28 | Calcaneovalgus deformity (HP:0001848) | 3.60671219 |
29 | Muscle fiber splitting (HP:0003555) | 3.55877330 |
30 | Abnormal EKG (HP:0003115) | 3.52416752 |
31 | Frequent falls (HP:0002359) | 3.49886087 |
32 | Neck muscle weakness (HP:0000467) | 3.48762147 |
33 | Palpitations (HP:0001962) | 3.46892381 |
34 | Syncope (HP:0001279) | 3.34770449 |
35 | Hyporeflexia of lower limbs (HP:0002600) | 3.28545607 |
36 | EMG: myopathic abnormalities (HP:0003458) | 3.25778725 |
37 | Myotonia (HP:0002486) | 3.25571498 |
38 | Deformed tarsal bones (HP:0008119) | 3.22153484 |
39 | Subaortic stenosis (HP:0001682) | 3.21755545 |
40 | Abnormality of the left ventricular outflow tract (HP:0011103) | 3.21755545 |
41 | Absent phalangeal crease (HP:0006109) | 3.15491215 |
42 | Difficulty running (HP:0009046) | 3.13316014 |
43 | Distal lower limb muscle weakness (HP:0009053) | 3.08738726 |
44 | Malignant hyperthermia (HP:0002047) | 3.04330222 |
45 | Lipoatrophy (HP:0100578) | 3.04159623 |
46 | Rhabdomyolysis (HP:0003201) | 3.04101789 |
47 | Ventricular arrhythmia (HP:0004308) | 2.98895063 |
48 | Ventricular fibrillation (HP:0001663) | 2.97238207 |
49 | Dilated cardiomyopathy (HP:0001644) | 2.92147605 |
50 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.85199969 |
51 | Asymmetric septal hypertrophy (HP:0001670) | 2.83218133 |
52 | Acute necrotizing encephalopathy (HP:0006965) | 2.82343262 |
53 | Resting tremor (HP:0002322) | 2.81504218 |
54 | Focal seizures (HP:0007359) | 2.80216277 |
55 | Blue irides (HP:0000635) | 2.78652714 |
56 | Anxiety (HP:0000739) | 2.72478137 |
57 | Distal lower limb amyotrophy (HP:0008944) | 2.72190387 |
58 | Abnormal finger flexion creases (HP:0006143) | 2.70054079 |
59 | Pheochromocytoma (HP:0002666) | 2.67700838 |
60 | Poor eye contact (HP:0000817) | 2.66918812 |
61 | Increased connective tissue (HP:0009025) | 2.64219113 |
62 | Increased variability in muscle fiber diameter (HP:0003557) | 2.64023205 |
63 | Ketoacidosis (HP:0001993) | 2.63858273 |
64 | Acute encephalopathy (HP:0006846) | 2.61608687 |
65 | Lower limb amyotrophy (HP:0007210) | 2.61461904 |
66 | EMG: neuropathic changes (HP:0003445) | 2.60362653 |
67 | Torticollis (HP:0000473) | 2.60053989 |
68 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.59872007 |
69 | Areflexia of lower limbs (HP:0002522) | 2.58108338 |
70 | Dysmetric saccades (HP:0000641) | 2.56180296 |
71 | Left ventricular hypertrophy (HP:0001712) | 2.54468344 |
72 | White forelock (HP:0002211) | 2.54244556 |
73 | Muscle stiffness (HP:0003552) | 2.52909899 |
74 | Hepatic necrosis (HP:0002605) | 2.51522542 |
75 | Right ventricular cardiomyopathy (HP:0011663) | 2.45841445 |
76 | Patchy hypopigmentation of hair (HP:0011365) | 2.45530010 |
77 | Impaired social interactions (HP:0000735) | 2.44956230 |
78 | Abnormal social behavior (HP:0012433) | 2.44956230 |
79 | Neuroendocrine neoplasm (HP:0100634) | 2.44107781 |
80 | Weak cry (HP:0001612) | 2.43078819 |
81 | Progressive macrocephaly (HP:0004481) | 2.42798129 |
82 | Hypoglycemic seizures (HP:0002173) | 2.42121602 |
83 | Hyperkalemia (HP:0002153) | 2.41085683 |
84 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.39826784 |
85 | Subcapsular cataract (HP:0000523) | 2.38449029 |
86 | Gowers sign (HP:0003391) | 2.37527269 |
87 | Hip contracture (HP:0003273) | 2.35986293 |
88 | Generalized muscle weakness (HP:0003324) | 2.33606146 |
89 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.33343558 |
90 | Aplasia/Hypoplasia of the macula (HP:0008059) | 2.33272415 |
91 | Hepatocellular necrosis (HP:0001404) | 2.26810638 |
92 | Craniofacial dystonia (HP:0012179) | 2.26403934 |
93 | Cerebral edema (HP:0002181) | 2.25069820 |
94 | Muscle fiber inclusion bodies (HP:0100299) | 2.24490823 |
95 | Focal dystonia (HP:0004373) | 2.24041506 |
96 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.23190913 |
97 | Mitochondrial inheritance (HP:0001427) | 2.21503459 |
98 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.19991020 |
99 | Central scotoma (HP:0000603) | 2.16236855 |
100 | Aplasia/Hypoplasia affecting the retina (HP:0008061) | 2.16170551 |
101 | Testicular atrophy (HP:0000029) | 2.15840233 |
102 | Ketosis (HP:0001946) | 2.15349421 |
103 | Depression (HP:0000716) | 2.12845210 |
104 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.12831182 |
105 | Popliteal pterygium (HP:0009756) | 2.12558685 |
106 | Limb-girdle muscle atrophy (HP:0003797) | 2.12363378 |
107 | Increased CSF lactate (HP:0002490) | 2.09848983 |
108 | Broad-based gait (HP:0002136) | 2.08555867 |
109 | Proximal amyotrophy (HP:0007126) | 2.07091235 |
110 | Fatigable weakness (HP:0003473) | 2.06236846 |
111 | Abnormality of the neuromuscular junction (HP:0003398) | 2.06236846 |
112 | Hypoglycemic coma (HP:0001325) | 2.05314254 |
113 | Dysdiadochokinesis (HP:0002075) | 2.04749731 |
114 | Bulbar palsy (HP:0001283) | 2.01455087 |
115 | Visual hallucinations (HP:0002367) | 2.01047429 |
116 | Scapular winging (HP:0003691) | 2.00919152 |
117 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.00650595 |
118 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.00465451 |
119 | Dicarboxylic aciduria (HP:0003215) | 2.00465451 |
120 | Limb hypertonia (HP:0002509) | 1.99663017 |
121 | Metatarsus adductus (HP:0001840) | 1.98561667 |
122 | Difficulty climbing stairs (HP:0003551) | 1.98151718 |
123 | Increased muscle lipid content (HP:0009058) | 1.98021845 |
124 | Type 1 muscle fiber predominance (HP:0003803) | 1.95982371 |
125 | Abnormality of the foot musculature (HP:0001436) | 1.95463378 |
126 | Lactic acidosis (HP:0003128) | 1.93738495 |
127 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.93311930 |
128 | Hypoplasia of the fovea (HP:0007750) | 1.93311930 |
129 | Hyperammonemia (HP:0001987) | 1.93306566 |
130 | Scotoma (HP:0000575) | 1.93198106 |
131 | Generalized tonic-clonic seizures (HP:0002069) | 1.91958188 |
132 | Intestinal atresia (HP:0011100) | 1.91619740 |
133 | Polar cataract (HP:0010696) | 1.90334138 |
134 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.89455116 |
135 | Abnormality of alanine metabolism (HP:0010916) | 1.89455116 |
136 | Hyperalaninemia (HP:0003348) | 1.89455116 |
137 | Congenital stationary night blindness (HP:0007642) | 1.88982932 |
138 | Athetosis (HP:0002305) | 1.88403044 |
139 | Hyperglycinuria (HP:0003108) | 1.87838291 |
140 | Urinary urgency (HP:0000012) | 1.87691295 |
141 | Annular pancreas (HP:0001734) | 1.87354991 |
142 | Nonprogressive disorder (HP:0003680) | 1.85392149 |
143 | Action tremor (HP:0002345) | 1.84221794 |
144 | Foot dorsiflexor weakness (HP:0009027) | 1.83914476 |
145 | Type 2 muscle fiber atrophy (HP:0003554) | 1.83078672 |
146 | Exercise intolerance (HP:0003546) | 1.82875889 |
147 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.82770877 |
148 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.82770877 |
149 | Rimmed vacuoles (HP:0003805) | 1.82725498 |
150 | Ankle clonus (HP:0011448) | 1.82538664 |
151 | Hyperventilation (HP:0002883) | 1.82383552 |
152 | Hyperglycemia (HP:0003074) | 1.81599529 |
153 | Abnormality of the calcaneus (HP:0008364) | 1.81446171 |
154 | Muscular dystrophy (HP:0003560) | 1.81301703 |
155 | Akinesia (HP:0002304) | 1.81292866 |
156 | Large for gestational age (HP:0001520) | 1.77594269 |
157 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.74639634 |
158 | Iris hypopigmentation (HP:0007730) | 1.73126602 |
159 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.70727030 |
160 | Ocular albinism (HP:0001107) | 1.70712049 |
161 | Aplasia of the musculature (HP:0100854) | 1.69866554 |
162 | Shoulder girdle muscle weakness (HP:0003547) | 1.69025567 |
163 | Steppage gait (HP:0003376) | 1.68011278 |
164 | Limb-girdle muscle weakness (HP:0003325) | 1.66877224 |
165 | Limited hip movement (HP:0008800) | 1.66367896 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EPHA4 | 6.10962118 |
2 | PHKG1 | 3.46358039 |
3 | PHKG2 | 3.46358039 |
4 | TTN | 2.99398150 |
5 | NTRK3 | 2.97177228 |
6 | LMTK2 | 2.79835445 |
7 | PINK1 | 2.68161039 |
8 | OBSCN | 2.31880293 |
9 | DAPK2 | 2.16376890 |
10 | PDK4 | 2.09159746 |
11 | PDK3 | 2.09159746 |
12 | PRKD3 | 2.02496942 |
13 | FRK | 1.94772805 |
14 | MAP3K9 | 1.85876784 |
15 | NEK1 | 1.84969836 |
16 | PIK3CG | 1.81470695 |
17 | KSR2 | 1.76836458 |
18 | ARAF | 1.65331289 |
19 | MARK1 | 1.55906791 |
20 | DMPK | 1.54049190 |
21 | MAP3K4 | 1.52920351 |
22 | CAMKK1 | 1.50458221 |
23 | TRIB3 | 1.48691555 |
24 | BCKDK | 1.46599370 |
25 | MAP3K13 | 1.41665588 |
26 | MAP2K4 | 1.36800551 |
27 | PIK3CA | 1.36022799 |
28 | MYLK | 1.33707792 |
29 | NTRK2 | 1.32849470 |
30 | MINK1 | 1.29725263 |
31 | SGK2 | 1.27411117 |
32 | PDK2 | 1.25667459 |
33 | DDR2 | 1.24039136 |
34 | ERBB3 | 1.21208668 |
35 | MUSK | 1.21141034 |
36 | TAOK1 | 1.20429698 |
37 | TNIK | 1.17461485 |
38 | GRK7 | 1.14739014 |
39 | SGK223 | 1.14387154 |
40 | SGK494 | 1.14387154 |
41 | CDK5 | 1.12059737 |
42 | SGK3 | 1.11628822 |
43 | MAP2K7 | 1.10843624 |
44 | EPHA3 | 1.10759390 |
45 | KSR1 | 1.10243950 |
46 | LIMK1 | 1.09777677 |
47 | TIE1 | 1.09753097 |
48 | PRPF4B | 1.08098166 |
49 | CAMKK2 | 1.07276992 |
50 | CAMK2A | 1.01547565 |
51 | STK38 | 0.95910467 |
52 | MAP4K2 | 0.95750171 |
53 | FES | 0.91963374 |
54 | CAMK2D | 0.90730520 |
55 | PAK6 | 0.89578798 |
56 | TRPM7 | 0.88180245 |
57 | MARK3 | 0.86272129 |
58 | FGFR2 | 0.86113696 |
59 | CAMK4 | 0.85810653 |
60 | MAPK12 | 0.85041272 |
61 | PAK3 | 0.84883050 |
62 | SGK1 | 0.84489783 |
63 | DYRK1B | 0.83042745 |
64 | RIPK4 | 0.82727841 |
65 | CCNB1 | 0.82357488 |
66 | MAPK13 | 0.79348021 |
67 | NTRK1 | 0.78848684 |
68 | RAF1 | 0.77940538 |
69 | PRKCH | 0.76186946 |
70 | DAPK1 | 0.75038631 |
71 | MOS | 0.74690551 |
72 | FLT3 | 0.72808370 |
73 | MAP2K6 | 0.72240839 |
74 | PDPK1 | 0.69408726 |
75 | PRKD1 | 0.68817279 |
76 | STK24 | 0.68564246 |
77 | AKT2 | 0.67649391 |
78 | CAMK2G | 0.67598072 |
79 | CAMK1 | 0.67364140 |
80 | MAP2K1 | 0.65064407 |
81 | PKN2 | 0.64389614 |
82 | PRKCG | 0.60946326 |
83 | MAP3K1 | 0.60726240 |
84 | NME1 | 0.60440903 |
85 | PDK1 | 0.60367936 |
86 | PRKG1 | 0.59981334 |
87 | CASK | 0.58996455 |
88 | CDC42BPA | 0.57696437 |
89 | PRKACA | 0.57119542 |
90 | INSRR | 0.56570279 |
91 | BMPR2 | 0.56058752 |
92 | UHMK1 | 0.55922582 |
93 | DAPK3 | 0.55791727 |
94 | MAP3K7 | 0.55780911 |
95 | MAP2K3 | 0.55543162 |
96 | MAP3K5 | 0.55474843 |
97 | CAMK2B | 0.54933511 |
98 | PRKACG | 0.54506512 |
99 | ROCK1 | 0.54360095 |
100 | PRKCE | 0.54012092 |
101 | LATS2 | 0.53744385 |
102 | MAPKAPK3 | 0.52757346 |
103 | RPS6KA3 | 0.51906599 |
104 | PTK2B | 0.49359049 |
105 | PRKAA1 | 0.48992346 |
106 | PKN1 | 0.48860513 |
107 | MAP3K12 | 0.48213199 |
108 | TYRO3 | 0.46629561 |
109 | RIPK1 | 0.46598669 |
110 | WNK3 | 0.46250831 |
111 | STK38L | 0.45868954 |
112 | STK11 | 0.45752828 |
113 | RPS6KA2 | 0.45745371 |
114 | PLK2 | 0.41777785 |
115 | MARK2 | 0.41301221 |
116 | PASK | 0.41014245 |
117 | PRKAA2 | 0.40765879 |
118 | CSNK1G2 | 0.40740339 |
119 | PRKACB | 0.38321088 |
120 | BRAF | 0.38197192 |
121 | SIK2 | 0.37763623 |
122 | DYRK1A | 0.37703827 |
123 | MAP3K2 | 0.37416618 |
124 | MAPK7 | 0.37113243 |
125 | RET | 0.36945632 |
126 | CSNK1G1 | 0.35642622 |
127 | EPHB1 | 0.34810079 |
128 | MAPK10 | 0.34629867 |
129 | FER | 0.33163589 |
130 | CSNK1G3 | 0.32224806 |
131 | CDK3 | 0.31182005 |
132 | MST1R | 0.29407005 |
133 | LATS1 | 0.28118204 |
134 | AKT3 | 0.28045927 |
135 | CSNK1A1L | 0.25172697 |
136 | FGFR3 | 0.24881095 |
137 | MAPK4 | 0.24858604 |
138 | GRK1 | 0.22048044 |
139 | CSNK1D | 0.21710236 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 3.71110610 |
2 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.87564056 |
3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.76050938 |
4 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.68520457 |
5 | Olfactory transduction_Homo sapiens_hsa04740 | 2.66138991 |
6 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.48217566 |
7 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.46232478 |
8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.33890773 |
9 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 2.21622890 |
10 | Morphine addiction_Homo sapiens_hsa05032 | 2.08889646 |
11 | GABAergic synapse_Homo sapiens_hsa04727 | 1.95429776 |
12 | Circadian entrainment_Homo sapiens_hsa04713 | 1.93969190 |
13 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.86264016 |
14 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.84828072 |
15 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.84654857 |
16 | Cocaine addiction_Homo sapiens_hsa05030 | 1.77338891 |
17 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.76817770 |
18 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.74794729 |
19 | Nicotine addiction_Homo sapiens_hsa05033 | 1.71427938 |
20 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.69006333 |
21 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.66620363 |
22 | Renin secretion_Homo sapiens_hsa04924 | 1.63178956 |
23 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.62797336 |
24 | Alzheimers disease_Homo sapiens_hsa05010 | 1.61354197 |
25 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.55138519 |
26 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.52722702 |
27 | Carbon metabolism_Homo sapiens_hsa01200 | 1.52576998 |
28 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.51158270 |
29 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.50621039 |
30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.45819957 |
31 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.45565667 |
32 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.44658425 |
33 | Long-term potentiation_Homo sapiens_hsa04720 | 1.44375516 |
34 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.43416775 |
35 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.43312827 |
36 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.35144369 |
37 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.34861740 |
38 | Insulin secretion_Homo sapiens_hsa04911 | 1.30343078 |
39 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.26689180 |
40 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.25138357 |
41 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.24276202 |
42 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.22329956 |
43 | Salivary secretion_Homo sapiens_hsa04970 | 1.20167923 |
44 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.15265761 |
45 | Huntingtons disease_Homo sapiens_hsa05016 | 1.13609497 |
46 | Gap junction_Homo sapiens_hsa04540 | 1.10387898 |
47 | Taste transduction_Homo sapiens_hsa04742 | 1.05292573 |
48 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.04462888 |
49 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.02534899 |
50 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.01708388 |
51 | Tight junction_Homo sapiens_hsa04530 | 1.01456704 |
52 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.01016022 |
53 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.00338577 |
54 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.91293794 |
55 | * PPAR signaling pathway_Homo sapiens_hsa03320 | 0.91252276 |
56 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.89809972 |
57 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.87902021 |
58 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.86246343 |
59 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.85884488 |
60 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.85752401 |
61 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.81504244 |
62 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.81031964 |
63 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.79088321 |
64 | Bile secretion_Homo sapiens_hsa04976 | 0.78166790 |
65 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.77603575 |
66 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.77189536 |
67 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.76554607 |
68 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.74713874 |
69 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.74330704 |
70 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.73079143 |
71 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.72726324 |
72 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.72041943 |
73 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.69555063 |
74 | Long-term depression_Homo sapiens_hsa04730 | 0.69499021 |
75 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.64988660 |
76 | Lysine degradation_Homo sapiens_hsa00310 | 0.64772251 |
77 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.63042777 |
78 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.61841996 |
79 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.60755650 |
80 | Insulin resistance_Homo sapiens_hsa04931 | 0.58867680 |
81 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.58815437 |
82 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.58777757 |
83 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.57378058 |
84 | * Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.57037103 |
85 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.56042609 |
86 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.55411115 |
87 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.51832869 |
88 | Melanogenesis_Homo sapiens_hsa04916 | 0.51228022 |
89 | Peroxisome_Homo sapiens_hsa04146 | 0.50757442 |
90 | Circadian rhythm_Homo sapiens_hsa04710 | 0.49707339 |
91 | Axon guidance_Homo sapiens_hsa04360 | 0.47469552 |
92 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.45093292 |
93 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.44877235 |
94 | Focal adhesion_Homo sapiens_hsa04510 | 0.42131300 |
95 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.41478798 |
96 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.41181084 |
97 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.40803830 |
98 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.40051675 |
99 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.39984293 |
100 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.38159356 |
101 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.38155959 |
102 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.36713084 |
103 | Protein export_Homo sapiens_hsa03060 | 0.36579923 |
104 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.36075126 |
105 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.35887788 |
106 | Phototransduction_Homo sapiens_hsa04744 | 0.35862370 |
107 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.35577902 |
108 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.34017900 |
109 | Glioma_Homo sapiens_hsa05214 | 0.33684199 |
110 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.32347436 |
111 | Galactose metabolism_Homo sapiens_hsa00052 | 0.31901629 |
112 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.31511608 |
113 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.30857005 |
114 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.30122381 |
115 | * Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.28674481 |
116 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.27992010 |