RYBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.27378100
2nuclear pore organization (GO:0006999)4.91730682
3nuclear pore complex assembly (GO:0051292)4.86623238
4regulation of gene silencing by RNA (GO:0060966)4.68346949
5regulation of posttranscriptional gene silencing (GO:0060147)4.68346949
6regulation of gene silencing by miRNA (GO:0060964)4.68346949
7regulation of T-helper 2 cell differentiation (GO:0045628)4.62776564
8neutrophil activation involved in immune response (GO:0002283)4.48077375
9negative regulation of T-helper cell differentiation (GO:0045623)4.24031144
10negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.24031144
11regulation of sister chromatid cohesion (GO:0007063)4.10670687
12regulation of T-helper 1 cell differentiation (GO:0045625)4.09200510
13regulation of RNA export from nucleus (GO:0046831)4.03075330
14positive regulation of gamma-delta T cell activation (GO:0046645)4.01796329
15negative regulation of interleukin-12 production (GO:0032695)4.00866367
16negative regulation of erythrocyte differentiation (GO:0045647)3.92090770
17positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.91138486
18negative regulation of histone methylation (GO:0031061)3.90148134
19regulation of hippo signaling (GO:0035330)3.87408313
20heterochromatin organization (GO:0070828)3.83416971
21protein localization to kinetochore (GO:0034501)3.83045205
22response to peptidoglycan (GO:0032494)3.78413026
23anterior/posterior axis specification, embryo (GO:0008595)3.73250702
24negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.70461831
25pore complex assembly (GO:0046931)3.63383580
26positive regulation by symbiont of host defense response (GO:0052509)3.62326005
27modulation by symbiont of host defense response (GO:0052031)3.62326005
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.62326005
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.62326005
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.62326005
31modulation by symbiont of host immune response (GO:0052553)3.62326005
32positive regulation of SMAD protein import into nucleus (GO:0060391)3.59770068
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.58838754
34paraxial mesoderm development (GO:0048339)3.58595961
35regulation of telomere maintenance via telomerase (GO:0032210)3.58063170
36intestinal epithelial cell development (GO:0060576)3.52369390
37mitotic metaphase plate congression (GO:0007080)3.50302588
38nerve growth factor signaling pathway (GO:0038180)3.49240089
39macrophage activation involved in immune response (GO:0002281)3.48799952
40* histone H2A monoubiquitination (GO:0035518)3.48285401
41positive regulation of chromosome segregation (GO:0051984)3.45532209
42histone H3-K36 demethylation (GO:0070544)3.44117441
43regulation of vitamin D biosynthetic process (GO:0060556)3.40900412
44mitotic nuclear envelope disassembly (GO:0007077)3.39706856
45negative regulation of cell killing (GO:0031342)3.36547132
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.36547132
47trophectodermal cell differentiation (GO:0001829)3.36255138
48DNA replication-dependent nucleosome organization (GO:0034723)3.35398636
49DNA replication-dependent nucleosome assembly (GO:0006335)3.35398636
50regulation of helicase activity (GO:0051095)3.35018899
51mitotic sister chromatid cohesion (GO:0007064)3.34399830
52mitotic sister chromatid segregation (GO:0000070)3.32276670
53sister chromatid segregation (GO:0000819)3.31917605
54polarized epithelial cell differentiation (GO:0030859)3.31844755
55membrane disassembly (GO:0030397)3.31363394
56nuclear envelope disassembly (GO:0051081)3.31363394
57detection of molecule of bacterial origin (GO:0032490)3.28719810
58histone H4-K12 acetylation (GO:0043983)3.26453085
59regulation of histone H3-K9 methylation (GO:0051570)3.23019106
60establishment of apical/basal cell polarity (GO:0035089)3.18158425
61regulation of nucleobase-containing compound transport (GO:0032239)3.17219368
62cellular extravasation (GO:0045123)3.15347217
63positive regulation of mitotic sister chromatid separation (GO:1901970)3.12896548
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12896548
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12896548
66chromatin assembly (GO:0031497)3.12608366
67spindle assembly involved in mitosis (GO:0090307)3.12039578
68positive regulation of mast cell activation (GO:0033005)3.11748939
69granulocyte activation (GO:0036230)3.11316904
70regulation of translational fidelity (GO:0006450)3.08469613
71neutrophil activation (GO:0042119)3.08069580
72positive regulation of type 2 immune response (GO:0002830)3.07756494
73attachment of spindle microtubules to kinetochore (GO:0008608)3.07219327
74negative regulation of interleukin-17 production (GO:0032700)3.07062823
75negative regulation of NF-kappaB import into nucleus (GO:0042347)3.04984136
76lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01938179
77protein K6-linked ubiquitination (GO:0085020)3.01787042
78microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.00606500
79DNA unwinding involved in DNA replication (GO:0006268)2.99478121
80leukocyte migration involved in inflammatory response (GO:0002523)2.99218327
81metaphase plate congression (GO:0051310)2.99175843
82JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.97723019
83regulation of translational termination (GO:0006449)2.97583263
84histamine secretion (GO:0001821)2.95897853
85protein localization to chromosome, centromeric region (GO:0071459)2.95815854
86gene silencing by RNA (GO:0031047)2.95565938
87ribosome assembly (GO:0042255)2.92619479
88regulation of SMAD protein import into nucleus (GO:0060390)2.92444594
89germinal center formation (GO:0002467)2.91756980
90notochord development (GO:0030903)2.90686538
91ectodermal placode formation (GO:0060788)2.89173748
92regulation of podosome assembly (GO:0071801)2.84485791
93positive regulation of cellular amide metabolic process (GO:0034250)2.84434753
94regulation of spindle organization (GO:0090224)2.83910774
95regulation of centriole replication (GO:0046599)2.83490113
96embryonic process involved in female pregnancy (GO:0060136)2.83181571
97negative regulation of alpha-beta T cell activation (GO:0046636)2.82534956
98NLS-bearing protein import into nucleus (GO:0006607)2.80096207
99regulation of chromosome segregation (GO:0051983)2.79628705
100regulation of regulatory T cell differentiation (GO:0045589)2.78955457
101mitotic chromosome condensation (GO:0007076)2.78932160
102regulation of gene silencing (GO:0060968)2.78303612
103regulation of gamma-delta T cell activation (GO:0046643)2.77952667
104somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77703571
105somatic hypermutation of immunoglobulin genes (GO:0016446)2.77703571
106negative regulation of alpha-beta T cell differentiation (GO:0046639)2.76938623
107protein localization to chromosome (GO:0034502)2.76061746
108DNA duplex unwinding (GO:0032508)2.75802621
109hippo signaling (GO:0035329)2.75632867
110macrophage activation (GO:0042116)2.74437516
111DNA geometric change (GO:0032392)2.74191296
112Rap protein signal transduction (GO:0032486)2.74029976
113establishment of monopolar cell polarity (GO:0061162)2.73737086
114establishment or maintenance of monopolar cell polarity (GO:0061339)2.73737086
115nuclear envelope organization (GO:0006998)2.73149202
116microglial cell activation (GO:0001774)2.72689534
117positive regulation of alpha-beta T cell proliferation (GO:0046641)2.72049808
118negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.71788573
119histone H4-K8 acetylation (GO:0043982)2.69644410
120histone H4-K5 acetylation (GO:0043981)2.69644410
121dosage compensation (GO:0007549)2.69180117
122negative regulation of T cell mediated immunity (GO:0002710)2.69075378
123dorsal/ventral axis specification (GO:0009950)2.68414160
124negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.66924505
125cytoplasmic mRNA processing body assembly (GO:0033962)2.66089595
126positive regulation of Rap GTPase activity (GO:0032854)2.65920644
127response to nerve growth factor (GO:1990089)2.65352892
128cellular response to nerve growth factor stimulus (GO:1990090)2.65352892
129establishment of chromosome localization (GO:0051303)2.64747944
130regulation of alpha-beta T cell proliferation (GO:0046640)2.64129228
131regulation of type 2 immune response (GO:0002828)2.63149684
132negative regulation of histone modification (GO:0031057)2.62369992
133mRNA transport (GO:0051028)2.62219558
134mRNA stabilization (GO:0048255)2.61013635
135RNA stabilization (GO:0043489)2.61013635
136peptidyl-arginine omega-N-methylation (GO:0035247)2.60588818
137regulation of memory T cell differentiation (GO:0043380)2.60481584
138peptidyl-lysine dimethylation (GO:0018027)2.59210288
139negative regulation of chromatin modification (GO:1903309)2.58951213
140thrombin receptor signaling pathway (GO:0070493)2.58679554
141positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.58600813
142spliceosomal tri-snRNP complex assembly (GO:0000244)2.57932446
143negative regulation of DNA repair (GO:0045738)2.56691312
144gene silencing (GO:0016458)2.52773943
145regulation of cAMP-dependent protein kinase activity (GO:2000479)2.51970208
146regulation of mitotic spindle organization (GO:0060236)2.51911463
147labyrinthine layer development (GO:0060711)2.51791073
148nucleobase biosynthetic process (GO:0046112)2.51177875
149folic acid-containing compound biosynthetic process (GO:0009396)2.51075205
150positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.51056879
151regulation of platelet aggregation (GO:0090330)2.50860730
152regulation of DNA methylation (GO:0044030)2.50507069
153regulation of centrosome cycle (GO:0046605)2.50274129
154lung-associated mesenchyme development (GO:0060484)2.50130959
155negative regulation of cytokine production involved in immune response (GO:0002719)2.49701855
156regulation of T-helper cell differentiation (GO:0045622)2.49630595
157negative regulation of neurotransmitter secretion (GO:0046929)2.49444687
158histone arginine methylation (GO:0034969)2.49404721
159peptidyl-arginine methylation (GO:0018216)2.49247795
160peptidyl-arginine N-methylation (GO:0035246)2.49247795
161negative regulation of mRNA processing (GO:0050686)2.49117790
162spindle checkpoint (GO:0031577)2.48031817
163cellular response to ethanol (GO:0071361)2.47431511
164regulation of mast cell degranulation (GO:0043304)2.47393488
165definitive hemopoiesis (GO:0060216)2.47023992
166positive regulation of T-helper cell differentiation (GO:0045624)2.46358274
167regulation of platelet activation (GO:0010543)2.44094189
168regulation of leukocyte degranulation (GO:0043300)2.43085031
169regulation of NFAT protein import into nucleus (GO:0051532)2.42105402
170neutrophil mediated immunity (GO:0002446)2.41678215
171positive regulation of p38MAPK cascade (GO:1900745)2.41647577
172detection of other organism (GO:0098543)2.41498218
173tolerance induction (GO:0002507)2.40792229
174positive regulation of leukocyte degranulation (GO:0043302)2.40402017
175response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.40057539
176response to host immune response (GO:0052572)2.40057539
177regulation of clathrin-mediated endocytosis (GO:2000369)2.39031983
178regulation of Rap GTPase activity (GO:0032317)2.35972935
179myeloid cell activation involved in immune response (GO:0002275)2.35947509
180regulation of early endosome to late endosome transport (GO:2000641)2.34519261
181regulation of interferon-beta biosynthetic process (GO:0045357)2.34163418
182regulation of erythrocyte differentiation (GO:0045646)2.33748043
183interleukin-6-mediated signaling pathway (GO:0070102)2.31950567
184detection of external biotic stimulus (GO:0098581)2.31771953
185regulation of mast cell activation (GO:0033003)2.31749396
186antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.31726737
187regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.31044077
188regulation of vitamin metabolic process (GO:0030656)2.30810775
189histone lysine demethylation (GO:0070076)2.30798772
190regulation of NF-kappaB import into nucleus (GO:0042345)2.30621276
191erythrocyte maturation (GO:0043249)2.30444930
192positive regulation of T cell cytokine production (GO:0002726)2.29373265
193megakaryocyte development (GO:0035855)2.28318301
194regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.28288292
195monoubiquitinated protein deubiquitination (GO:0035520)2.27755948
196cellular response to thyroid hormone stimulus (GO:0097067)2.27256221
197negative regulation of type 2 immune response (GO:0002829)2.26404482
198positive regulation of B cell differentiation (GO:0045579)2.26335071
199positive regulation of isotype switching (GO:0045830)2.25941324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93592770
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.52634665
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.41598805
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.56744915
5* KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.43194239
6* KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.43194239
7* KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.43194239
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.39527257
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.15885883
10* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.96059540
11* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.83325293
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.82858373
13ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.79541075
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77794434
15SCL_19346495_ChIP-Seq_HPC-7_Human2.70326925
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69838256
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.67321736
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65533086
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.65476542
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.54980488
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.51011554
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.50695273
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48544865
24* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48494523
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.46667352
26IRF8_21731497_ChIP-ChIP_J774_Mouse2.41182974
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40053097
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37464450
29NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.36653334
30STAT6_21828071_ChIP-Seq_BEAS2B_Human2.30945401
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27661059
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26956128
33TCF3_18692474_ChIP-Seq_MEFs_Mouse2.18740484
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16739552
35TCF3_18692474_ChIP-Seq_MESCs_Mouse2.15117309
36* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.11874983
37AR_21909140_ChIP-Seq_LNCAP_Human2.09217735
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99436480
39* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.96378320
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93265592
41* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92908304
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.88280156
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87144828
44* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.85617245
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.85361831
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.83499311
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82249023
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81558931
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.81365374
50VDR_24787735_ChIP-Seq_THP-1_Human1.80981505
51* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75499848
52MYC_22102868_ChIP-Seq_BL_Human1.74302517
53ZNF263_19887448_ChIP-Seq_K562_Human1.72407682
54* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72353855
55* WT1_19549856_ChIP-ChIP_CCG9911_Human1.70772631
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.70498757
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.70095656
58NANOG_21062744_ChIP-ChIP_HESCs_Human1.69624612
59GATA1_19941826_ChIP-Seq_K562_Human1.65996979
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63733366
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.62474095
62* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61362056
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60917084
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60509976
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.59787236
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59290740
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56419397
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.55851620
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54178391
70* RUNX_20019798_ChIP-Seq_JUKART_Human1.52738177
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52515716
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.52110362
73* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51960013
74* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.51287959
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51265213
76* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50515400
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49671320
78* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.48964442
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.47743939
80TCF7_22412390_ChIP-Seq_EML_Mouse1.47735202
81PKCTHETA_26484144_Chip-Seq_BREAST_Human1.42515731
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38703488
83PU_27001747_Chip-Seq_BMDM_Mouse1.38330941
84* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.37727851
85* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36421676
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35935784
87* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.35696624
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35367877
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34196762
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33722502
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.33567339
92* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32990121
93* GATA2_19941826_ChIP-Seq_K562_Human1.31338994
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30992941
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30639166
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27143693
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27143693
98SPI1_23127762_ChIP-Seq_K562_Human1.24940876
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24681957
100* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.24277558
101* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23940777
102CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23279518
103* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22864024
104* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21935690
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21408003
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21136812
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20876708
108KDM5A_27292631_Chip-Seq_BREAST_Human1.20332874
109CHD1_26751641_Chip-Seq_LNCaP_Human1.18571375
110* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.17797000
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16976505
112RUNX1_22412390_ChIP-Seq_EML_Mouse1.16449586
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14299458
114ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14241748
115VDR_24763502_ChIP-Seq_THP-1_Human1.12582861
116* MYB_26560356_Chip-Seq_TH2_Human1.11275065
117RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10827068
118* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10299950
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10266765
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09828619
121GATA1_22025678_ChIP-Seq_K562_Human1.08594422
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08181297
123* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08108161
124* NANOG_16518401_ChIP-PET_MESCs_Mouse1.07908188
125* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07779004
126* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05270089
127KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04665510
128* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04119971
129ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04003794
130* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03916486
131* GF1_26923725_Chip-Seq_HPCs_Mouse1.03702363
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03489666
133GATA1_26923725_Chip-Seq_HPCs_Mouse1.03197629
134GATA2_21666600_ChIP-Seq_HMVEC_Human1.01662229
135XRN2_22483619_ChIP-Seq_HELA_Human1.01452236
136* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01309985
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01166204
138* PIAS1_25552417_ChIP-Seq_VCAP_Human1.00386412
139TFEB_21752829_ChIP-Seq_HELA_Human0.99639125
140SPI1_23547873_ChIP-Seq_NB4_Human0.99557267
141* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99444562
142* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98805766
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98547110
144KDM2B_26808549_Chip-Seq_K562_Human0.97662130
145KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97293475
146KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97120939
147* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95560830
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95388201
149* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95139834
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94782534
151PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94473064
152EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94286598
153ATF3_27146783_Chip-Seq_COLON_Human0.93516820
154POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.92777463
155KDM2B_26808549_Chip-Seq_JURKAT_Human0.92525062
156TP53_16413492_ChIP-PET_HCT116_Human0.91562463
157BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91437972
158* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91435234
159* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91435234
160* KAP1_27257070_Chip-Seq_ESCs_Mouse0.91300999
161* GF1B_26923725_Chip-Seq_HPCs_Mouse0.90742183
162CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90688202
163* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90659011
164* GATA1_19941827_ChIP-Seq_MEL_Mouse0.90638747
165KDM2B_26808549_Chip-Seq_DND41_Human0.90518018
166* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89380621
167IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89015438
168ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87989657
169EWS_26573619_Chip-Seq_HEK293_Human0.87976779
170POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87923974
171TAF15_26573619_Chip-Seq_HEK293_Human0.86516867
172MYB_26560356_Chip-Seq_TH1_Human0.86457644
173NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85471587
174CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84270782
175* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83913217
176SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83547674
177* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80415428
178* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80387338
179CMYC_18555785_Chip-Seq_ESCs_Mouse0.79644996
180* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79081242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.19851317
2MP0003300_gastrointestinal_ulcer4.15293092
3MP0008004_abnormal_stomach_pH3.93193012
4MP0003724_increased_susceptibility_to3.79963258
5MP0010234_abnormal_vibrissa_follicle3.70309441
6MP0005464_abnormal_platelet_physiology3.16873946
7MP0003123_paternal_imprinting3.07084234
8* MP0004957_abnormal_blastocyst_morpholog2.84442600
9MP0003111_abnormal_nucleus_morphology2.78668885
10MP0004510_myositis2.76152777
11MP0005076_abnormal_cell_differentiation2.65755916
12MP0008057_abnormal_DNA_replication2.55981251
13MP0003693_abnormal_embryo_hatching2.52979111
14MP0010352_gastrointestinal_tract_polyps2.48406404
15MP0000537_abnormal_urethra_morphology2.41984064
16MP0003077_abnormal_cell_cycle2.39494099
17MP0003890_abnormal_embryonic-extraembry2.37081430
18MP0004808_abnormal_hematopoietic_stem2.35964827
19MP0001730_embryonic_growth_arrest2.33711720
20MP0003121_genomic_imprinting2.31489079
21MP0002084_abnormal_developmental_patter2.30585452
22MP0003119_abnormal_digestive_system2.28019732
23MP0010094_abnormal_chromosome_stability2.27574033
24MP0004264_abnormal_extraembryonic_tissu2.23445048
25MP0003283_abnormal_digestive_organ2.12184875
26MP0003436_decreased_susceptibility_to2.11132822
27* MP0002085_abnormal_embryonic_tissue2.02953929
28MP0001849_ear_inflammation2.02875712
29MP0001545_abnormal_hematopoietic_system2.02200197
30MP0005397_hematopoietic_system_phenotyp2.02200197
31MP0002653_abnormal_ependyma_morphology2.00746649
32* MP0001672_abnormal_embryogenesis/_devel2.00046373
33* MP0005380_embryogenesis_phenotype2.00046373
34MP0003705_abnormal_hypodermis_morpholog1.98941884
35MP0000350_abnormal_cell_proliferation1.97115181
36MP0001835_abnormal_antigen_presentation1.96058558
37MP0004197_abnormal_fetal_growth/weight/1.94938951
38* MP0002086_abnormal_extraembryonic_tissu1.94712401
39MP0010307_abnormal_tumor_latency1.92746890
40MP0001697_abnormal_embryo_size1.91025315
41MP0004947_skin_inflammation1.89460111
42MP0005000_abnormal_immune_tolerance1.88265430
43MP0002148_abnormal_hypersensitivity_rea1.85851445
44MP0003828_pulmonary_edema1.83466558
45MP0005623_abnormal_meninges_morphology1.82849688
46* MP0003984_embryonic_growth_retardation1.80103854
47MP0005409_darkened_coat_color1.79162228
48MP0003656_abnormal_erythrocyte_physiolo1.78537851
49* MP0002088_abnormal_embryonic_growth/wei1.78459097
50MP0001790_abnormal_immune_system1.70782507
51MP0005387_immune_system_phenotype1.70782507
52MP0002419_abnormal_innate_immunity1.66699167
53MP0003941_abnormal_skin_development1.66433705
54MP0001293_anophthalmia1.61133361
55MP0003172_abnormal_lysosome_physiology1.59204518
56MP0004133_heterotaxia1.58673729
57MP0003567_abnormal_fetal_cardiomyocyte1.58153356
58MP0002998_abnormal_bone_remodeling1.56821448
59MP0003091_abnormal_cell_migration1.56594662
60MP0003937_abnormal_limbs/digits/tail_de1.55238895
61MP0010155_abnormal_intestine_physiology1.53383078
62MP0000428_abnormal_craniofacial_morphol1.53341050
63MP0008877_abnormal_DNA_methylation1.52107223
64MP0009785_altered_susceptibility_to1.49706352
65MP0010030_abnormal_orbit_morphology1.47171809
66* MP0002080_prenatal_lethality1.46571499
67MP0002723_abnormal_immune_serum1.44982550
68MP0003195_calcinosis1.44045122
69MP0001800_abnormal_humoral_immune1.43870810
70MP0009703_decreased_birth_body1.41779874
71MP0009053_abnormal_anal_canal1.41602643
72MP0002452_abnormal_antigen_presenting1.41187402
73MP0008932_abnormal_embryonic_tissue1.40631957
74MP0003787_abnormal_imprinting1.40575346
75MP0001851_eye_inflammation1.40155191
76MP0008058_abnormal_DNA_repair1.39878273
77MP0005187_abnormal_penis_morphology1.39698599
78MP0002398_abnormal_bone_marrow1.39496597
79MP0003566_abnormal_cell_adhesion1.39429485
80MP0010678_abnormal_skin_adnexa1.38830730
81MP0002877_abnormal_melanocyte_morpholog1.38673053
82MP0002405_respiratory_system_inflammati1.37536375
83MP0003755_abnormal_palate_morphology1.37331271
84MP0002132_abnormal_respiratory_system1.36308215
85MP0000516_abnormal_urinary_system1.33890346
86MP0005367_renal/urinary_system_phenotyp1.33890346
87MP0009672_abnormal_birth_weight1.32322235
88MP0003935_abnormal_craniofacial_develop1.32235281
89MP0003122_maternal_imprinting1.32145983
90MP0005025_abnormal_response_to1.28077896
91MP0006082_CNS_inflammation1.26993780
92* MP0003861_abnormal_nervous_system1.24716413
93MP0005310_abnormal_salivary_gland1.24326974
94MP0001819_abnormal_immune_cell1.22764006
95MP0002420_abnormal_adaptive_immunity1.22523477
96MP0001188_hyperpigmentation1.21794682
97MP0008260_abnormal_autophagy1.19648931
98MP0004185_abnormal_adipocyte_glucose1.15484508
99MP0000432_abnormal_head_morphology1.15377728
100MP0002277_abnormal_respiratory_mucosa1.15261232
101MP0003448_altered_tumor_morphology1.15072296
102MP0001533_abnormal_skeleton_physiology1.14843285
103MP0005058_abnormal_lysosome_morphology1.13260330
104MP0002111_abnormal_tail_morphology1.12430691
105MP0005671_abnormal_response_to1.12256902
106MP0008007_abnormal_cellular_replicative1.11569892
107MP0005084_abnormal_gallbladder_morpholo1.10435832
108MP0001915_intracranial_hemorrhage1.09917171
109MP0009333_abnormal_splenocyte_physiolog1.09706471
110MP0003718_maternal_effect1.09471456
111MP0002925_abnormal_cardiovascular_devel1.08855206
112MP0002254_reproductive_system_inflammat1.07117237
113MP0002166_altered_tumor_susceptibility1.06677947
114MP0002092_abnormal_eye_morphology1.06533712
115MP0001845_abnormal_inflammatory_respons1.04237298
116MP0005647_abnormal_sex_gland1.04075774
117MP0000465_gastrointestinal_hemorrhage1.03418731
118MP0000733_abnormal_muscle_development1.03220564
119MP0004885_abnormal_endolymph1.03210631
120MP0002006_tumorigenesis1.02757321
121MP0000716_abnormal_immune_system1.02689682
122MP0000858_altered_metastatic_potential1.01125552
123MP0002722_abnormal_immune_system0.99123339
124MP0000689_abnormal_spleen_morphology0.98737335
125MP0004272_abnormal_basement_membrane0.98650455
126MP0003115_abnormal_respiratory_system0.98157706
127MP0002697_abnormal_eye_size0.97046685
128MP0000703_abnormal_thymus_morphology0.96867362
129MP0009764_decreased_sensitivity_to0.95841354
130MP0002009_preneoplasia0.92912079
131MP0000678_abnormal_parathyroid_gland0.92696101
132MP0003385_abnormal_body_wall0.92606564
133* MP0001286_abnormal_eye_development0.92407434
134MP0001879_abnormal_lymphatic_vessel0.92209070
135MP0002429_abnormal_blood_cell0.91421953
136MP0000534_abnormal_ureter_morphology0.90827600
137MP0000343_altered_response_to0.90714331
138MP0000462_abnormal_digestive_system0.90689833
139MP0005248_abnormal_Harderian_gland0.90372139
140MP0009278_abnormal_bone_marrow0.90315099
141MP0002116_abnormal_craniofacial_bone0.90107418
142MP0001145_abnormal_male_reproductive0.88710923
143MP0006054_spinal_hemorrhage0.88656412
144MP0008961_abnormal_basal_metabolism0.86378630
145MP0003942_abnormal_urinary_system0.84902757
146MP0003690_abnormal_glial_cell0.84106540
147MP0002210_abnormal_sex_determination0.84045253
148MP0006072_abnormal_retinal_apoptosis0.80020489
149MP0003453_abnormal_keratinocyte_physiol0.79468979
150MP0000490_abnormal_crypts_of0.79051012
151MP0000015_abnormal_ear_pigmentation0.77599038
152* MP0002081_perinatal_lethality0.76163415
153MP0002233_abnormal_nose_morphology0.75786956
154MP0002796_impaired_skin_barrier0.75648685
155MP0005167_abnormal_blood-brain_barrier0.75059954
156MP0000569_abnormal_digit_pigmentation0.74989960
157MP0000604_amyloidosis0.73865377
158MP0000762_abnormal_tongue_morphology0.73476256
159MP0001784_abnormal_fluid_regulation0.73372143
160MP0000313_abnormal_cell_death0.73267520
161MP0000685_abnormal_immune_system0.73240528
162MP0000653_abnormal_sex_gland0.73202948
163MP0003943_abnormal_hepatobiliary_system0.72261970
164MP0005621_abnormal_cell_physiology0.72096918
165MP0005257_abnormal_intraocular_pressure0.71109911
166MP0002932_abnormal_joint_morphology0.70672937
167MP0009697_abnormal_copulation0.70567853
168MP0006292_abnormal_olfactory_placode0.70556868
169MP0001919_abnormal_reproductive_system0.70109263
170MP0002282_abnormal_trachea_morphology0.70092332
171MP0005384_cellular_phenotype0.69989822
172MP0002114_abnormal_axial_skeleton0.69499196
173MP0004883_abnormal_blood_vessel0.64992248
174MP0005164_abnormal_response_to0.62194112
175MP0005390_skeleton_phenotype0.61115903
176MP0001663_abnormal_digestive_system0.57826099
177MP0002133_abnormal_respiratory_system0.57285288

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)4.36352422
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.15242615
3Abnormal platelet volume (HP:0011876)3.78354901
4Increased mean platelet volume (HP:0011877)3.73576977
5Ependymoma (HP:0002888)3.65173486
6Spontaneous hematomas (HP:0007420)3.60800084
7Gingival bleeding (HP:0000225)3.50560839
8Stomatitis (HP:0010280)3.47579095
9Recurrent bacterial skin infections (HP:0005406)3.42383191
10Abnormality of the labia minora (HP:0012880)3.28325933
11Optic neuritis (HP:0100653)3.19726466
12Retrobulbar optic neuritis (HP:0100654)3.19726466
13Eczematoid dermatitis (HP:0000976)3.05322776
14Abnormality of macrophages (HP:0004311)3.04774398
15Menorrhagia (HP:0000132)3.02014477
16Petechiae (HP:0000967)2.95374111
17Abnormality of the astrocytes (HP:0100707)2.93961250
18Astrocytoma (HP:0009592)2.93961250
19Neoplasm of the oral cavity (HP:0100649)2.93406946
20Recurrent abscess formation (HP:0002722)2.93126432
21Epistaxis (HP:0000421)2.90736923
22Biliary tract neoplasm (HP:0100574)2.88223452
23Orchitis (HP:0100796)2.86132319
24Purpura (HP:0000979)2.84614050
25Bladder neoplasm (HP:0009725)2.76065062
26Bladder carcinoma (HP:0002862)2.76065062
27Medulloblastoma (HP:0002885)2.75738088
28Disinhibition (HP:0000734)2.73897281
29Myositis (HP:0100614)2.70977626
30Acanthocytosis (HP:0001927)2.70327135
31Volvulus (HP:0002580)2.67292103
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.67009043
33Missing ribs (HP:0000921)2.60924442
34Thyroid carcinoma (HP:0002890)2.58047104
35Breast hypoplasia (HP:0003187)2.57779583
36Shawl scrotum (HP:0000049)2.53399193
37Supernumerary ribs (HP:0005815)2.53387623
38Keratoconjunctivitis sicca (HP:0001097)2.53268673
39Esophageal atresia (HP:0002032)2.47284172
40Colon cancer (HP:0003003)2.46705719
41Malignant gastrointestinal tract tumors (HP:0006749)2.46673803
42Gastrointestinal carcinoma (HP:0002672)2.46673803
43Renal duplication (HP:0000075)2.46639346
44Symptomatic seizures (HP:0011145)2.44546590
45Hematochezia (HP:0002573)2.44249743
46Increased nuchal translucency (HP:0010880)2.43360947
47Aplasia/Hypoplasia of the sternum (HP:0006714)2.40510346
48Gastrointestinal infarctions (HP:0005244)2.38772869
49Facial hemangioma (HP:0000329)2.35988878
50Absent radius (HP:0003974)2.34219172
51Glioma (HP:0009733)2.34206911
52Arterial thrombosis (HP:0004420)2.32728171
53Short humerus (HP:0005792)2.32716431
54Macroorchidism (HP:0000053)2.32476673
55Poikilocytosis (HP:0004447)2.31098239
56Supernumerary bones of the axial skeleton (HP:0009144)2.29819541
57Aplasia/hypoplasia of the humerus (HP:0006507)2.28279961
58Rhabdomyosarcoma (HP:0002859)2.27588724
59Peritonitis (HP:0002586)2.26863469
60Abnormality of the vasculature of the conjunctiva (HP:0008054)2.23077673
61Broad thumb (HP:0011304)2.22465777
62Hypochromic microcytic anemia (HP:0004840)2.20410083
63Keratoconjunctivitis (HP:0001096)2.19653715
64Hypoplastic labia majora (HP:0000059)2.19303357
65Neoplasm of striated muscle (HP:0009728)2.18935468
66Absent forearm bone (HP:0003953)2.17627091
67Aplasia involving forearm bones (HP:0009822)2.17627091
68Shallow orbits (HP:0000586)2.17298101
69Abnormality of the fingertips (HP:0001211)2.17100677
70Deviation of the thumb (HP:0009603)2.17060403
71Hepatoblastoma (HP:0002884)2.14985389
72Rib fusion (HP:0000902)2.13496561
73Proximal placement of thumb (HP:0009623)2.12942583
74Neonatal hypoglycemia (HP:0001998)2.12003925
75Abnormality of calcium-phosphate metabolism (HP:0100530)2.10146550
76Subacute progressive viral hepatitis (HP:0006572)2.09069376
77Impulsivity (HP:0100710)2.06869966
78Supernumerary spleens (HP:0009799)2.06410006
79Absent eyebrow (HP:0002223)2.04594159
80Conjunctival telangiectasia (HP:0000524)2.03765978
81Papillary thyroid carcinoma (HP:0002895)2.03490244
82Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.03479541
83Bifid tongue (HP:0010297)2.03402642
84Overriding aorta (HP:0002623)2.03251732
85Basal ganglia calcification (HP:0002135)2.01219980
86Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.00607774
87Short 1st metacarpal (HP:0010034)2.00607774
88Patellar aplasia (HP:0006443)1.99900682
89Hyperparathyroidism (HP:0000843)1.99260671
90Curly hair (HP:0002212)1.98591565
91Abnormality of the labia majora (HP:0012881)1.98469410
92Deep philtrum (HP:0002002)1.98233104
93Short phalanx of the thumb (HP:0009660)1.97812591
94Episodic fever (HP:0001954)1.97249508
95Mutism (HP:0002300)1.95058184
96Selective tooth agenesis (HP:0001592)1.94669407
97T lymphocytopenia (HP:0005403)1.93518743
98Uterine neoplasm (HP:0010784)1.93112111
99Birth length less than 3rd percentile (HP:0003561)1.92441588
100Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91673880
101Short 4th metacarpal (HP:0010044)1.91673880
102Skull defect (HP:0001362)1.91463418
103Osteomalacia (HP:0002749)1.91345223
104Abnormality of the diencephalon (HP:0010662)1.91242788
105Impaired platelet aggregation (HP:0003540)1.91041246
106Abnormal platelet function (HP:0011869)1.91041246
107Sandal gap (HP:0001852)1.90053399
108Tetraparesis (HP:0002273)1.88950141
109Neoplasm of the tracheobronchial system (HP:0100552)1.88624801
110Obstructive sleep apnea (HP:0002870)1.88564341
111Aplasia/Hypoplasia of the patella (HP:0006498)1.86324076
112Asymmetry of the thorax (HP:0001555)1.86186986
113Cubitus valgus (HP:0002967)1.85666778
114Bronchomalacia (HP:0002780)1.85095733
115Abnormality of the salivary glands (HP:0010286)1.85013754
116Atresia of the external auditory canal (HP:0000413)1.84783082
117Abnormal biliary tract morphology (HP:0012440)1.84656102
118Abnormality of the lower motor neuron (HP:0002366)1.84182614
119Thickened calvaria (HP:0002684)1.84021140
120Mediastinal lymphadenopathy (HP:0100721)1.83706277
121Abnormal pancreas size (HP:0012094)1.83140443
122Gastrointestinal atresia (HP:0002589)1.82855604
123Agnosia (HP:0010524)1.82402014
124Fused cervical vertebrae (HP:0002949)1.82374336
125Pelvic girdle muscle weakness (HP:0003749)1.81746177
126Thickened helices (HP:0000391)1.81595947
127Hyperacusis (HP:0010780)1.80551374
128Thin bony cortex (HP:0002753)1.79823253
129Lymphedema (HP:0001004)1.79714381
130Microcytic anemia (HP:0001935)1.78601546
131Basal cell carcinoma (HP:0002671)1.78047620
132Ovarian neoplasm (HP:0100615)1.77896589
133Inappropriate behavior (HP:0000719)1.76943714
134Abnormal hair whorl (HP:0010721)1.76851311
135Shoulder girdle muscle weakness (HP:0003547)1.76688007
136Vertebral fusion (HP:0002948)1.75621821
137Intestinal polyp (HP:0005266)1.75475475
138Oligodactyly (HP:0012165)1.75152178
139Overlapping toe (HP:0001845)1.74856458
140Segmental peripheral demyelination/remyelination (HP:0003481)1.74604478
141Thrombocytosis (HP:0001894)1.73975846
142Increased IgE level (HP:0003212)1.73216001
143Abnormal umbilical cord blood vessels (HP:0011403)1.73031495
144Single umbilical artery (HP:0001195)1.73031495
145Abnormality of the fetal cardiovascular system (HP:0010948)1.73031495
146Genu recurvatum (HP:0002816)1.72996610
147Relative macrocephaly (HP:0004482)1.71873344
148Acute myeloid leukemia (HP:0004808)1.71580503
149Overgrowth (HP:0001548)1.71357532
150Widely patent fontanelles and sutures (HP:0004492)1.71317372
151Cerebral inclusion bodies (HP:0100314)1.71275510
152Recurrent viral infections (HP:0004429)1.71208072
153Breast aplasia (HP:0100783)1.70779862
154Gingivitis (HP:0000230)1.70049930
155Heterotopia (HP:0002282)1.70016241
156Renovascular hypertension (HP:0100817)1.69776636
157Ankyloglossia (HP:0010296)1.69713805
158Leukocytosis (HP:0001974)1.69243559
159Testicular neoplasm (HP:0010788)1.68558038
160Vertebral clefting (HP:0008428)1.68458010
161Intestinal polyposis (HP:0200008)1.68112149
162Abnormality of the 1st metacarpal (HP:0010009)1.67859735
163Encephalitis (HP:0002383)1.66707793
164Broad phalanges of the hand (HP:0009768)1.64860213
165Autoimmune thrombocytopenia (HP:0001973)1.64709007
166Neurofibrillary tangles (HP:0002185)1.64043312
167Amaurosis fugax (HP:0100576)1.63079323
168Sex reversal (HP:0012245)1.62645762
169Abnormal sex determination (HP:0012244)1.62645762
170Abnormality of the heme biosynthetic pathway (HP:0010472)1.62034573
171Cystic hygroma (HP:0000476)1.61979957
172Abdominal situs inversus (HP:0003363)1.61788690
173Abnormality of abdominal situs (HP:0011620)1.61788690
174Spinal muscular atrophy (HP:0007269)1.61135393
175Recurrent skin infections (HP:0001581)1.61133381
176Hemivertebrae (HP:0002937)1.60817774
177Pointed chin (HP:0000307)1.60670960
178Polycythemia (HP:0001901)1.60548438
179Premature loss of primary teeth (HP:0006323)1.60425759
180Renal cell carcinoma (HP:0005584)1.59459821
181Delayed puberty (HP:0000823)1.59270767
182Metaphyseal irregularity (HP:0003025)1.58439178
183Leiomyosarcoma (HP:0100243)1.57713759
184Uterine leiomyosarcoma (HP:0002891)1.57713759
185Transitional cell carcinoma of the bladder (HP:0006740)1.57108482
186Pulmonary embolism (HP:0002204)1.56234659
187Flat occiput (HP:0005469)1.55898217
188Vasculitis (HP:0002633)1.55623312
189Progressive inability to walk (HP:0002505)1.55324016
190Bilateral microphthalmos (HP:0007633)1.55140653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.14123907
2CDK123.84601647
3AKT33.33536819
4LATS13.07629197
5EPHA22.99288805
6NEK22.97989582
7RIPK42.96242915
8TNIK2.57510562
9TTK2.43809529
10PRPF4B2.35537752
11CDC72.30115683
12WEE12.22120764
13STK242.21231753
14SGK22.13284744
15LATS22.12624662
16MAP3K142.08494785
17PNCK1.98725512
18IRAK21.93686501
19MATK1.88633847
20NLK1.82280043
21YES11.79834360
22TYRO31.76098125
23SGK31.69303850
24ALK1.68597924
25IRAK11.67764529
26TSSK61.65398742
27FGR1.63822197
28PASK1.56273289
29MAP2K31.53413350
30IRAK41.53211265
31MAP3K91.48577059
32CAMK1G1.47385647
33CSK1.47325853
34RPS6KB21.46999476
35IKBKE1.46571351
36PRKD31.46135126
37IRAK31.45242185
38STK31.44588261
39MTOR1.37711265
40PLK31.36441657
41CDK61.35717576
42ICK1.34490502
43PDGFRA1.32661242
44BRD41.31087557
45SCYL21.30495518
46KSR21.29649958
47CDK71.29234604
48SGK4941.25879254
49SGK2231.25879254
50TAOK21.25835800
51MAP3K21.25112007
52MAP3K131.25072327
53MST41.25056330
54MAP3K31.23842306
55PLK11.22315228
56EEF2K1.20674825
57EIF2AK31.20550302
58MET1.19295047
59CHEK21.17245654
60PAK41.13643648
61MAP3K81.13250973
62CHEK11.12434445
63DDR21.10835998
64STK38L1.10573198
65FGFR31.09167384
66JAK31.07459354
67WNK11.06335921
68MAP3K11.05112855
69MKNK11.04872954
70BUB11.04257486
71PLK41.03654798
72DYRK31.01749940
73JAK21.00180768
74CAMK1D0.99528297
75MAP3K100.99487037
76TAF10.98121801
77BMPR20.97413596
78PKN20.95893182
79MELK0.94714563
80STK100.93971327
81IKBKB0.93767727
82FGFR20.93628964
83ATM0.93556188
84PRKCI0.91646464
85NEK90.91332555
86TEC0.91202354
87HCK0.91150802
88SRPK10.89824229
89EIF2AK10.89787412
90CDK20.88591368
91MAP3K60.87542408
92BTK0.87520197
93CSNK1A1L0.87519945
94CSNK1D0.86178562
95KSR10.85715115
96PTK20.85677632
97MARK20.85129334
98FER0.85011523
99CDK40.84773440
100DMPK0.84499450
101MAP3K50.84137423
102SYK0.83482063
103ZAP700.82782217
104CLK10.82371579
105AURKB0.82085962
106DYRK1B0.79062532
107BLK0.78603989
108CHUK0.75969195
109MKNK20.75267649
110CSNK1E0.74376516
111ATR0.73789906
112RIPK10.73399144
113PDGFRB0.71820206
114PTK60.68919810
115BRSK20.68107456
116CSNK1G20.67903476
117PAK20.66573980
118FGFR10.65750895
119WNK30.65617970
120LYN0.64729444
121STK110.64506821
122MAPK100.63231048
123CSNK1G30.62891646
124CDK10.61793158
125TAOK10.60977306
126NTRK30.60669812
127CSNK1G10.59426443
128HIPK20.58372850
129PAK60.58226050
130JAK10.57915891
131BRAF0.57725545
132RPS6KC10.57530580
133RPS6KL10.57530580
134RPS6KA40.57519370
135GSK3A0.57157050
136AURKA0.56603501
137DAPK20.54498206
138SGK10.53826631
139FES0.53751175
140ERBB40.53237079
141DYRK1A0.52656503
142ACVR1B0.46846355
143BMX0.46256429
144GSK3B0.45993973
145MAPK140.45237469
146RPS6KA10.45216175
147DYRK20.45170117
148CDK190.44470357
149RPS6KA60.43672711
150PRKDC0.43630370
151MAPK10.42108378
152TYK20.39393889
153RET0.39122865
154TGFBR10.37991367
155CAMKK20.37797937
156TRIB30.37502750
157LCK0.37217398
158STK40.37204865
159RPS6KA20.37064315
160RPS6KA50.35764918
161AKT20.35620366
162AKT10.35084396
163PIM10.35062395
164BCR0.34652155

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030132.83155087
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50218274
3mRNA surveillance pathway_Homo sapiens_hsa030152.39882910
4Cell cycle_Homo sapiens_hsa041102.26774335
5Osteoclast differentiation_Homo sapiens_hsa043802.21318313
6B cell receptor signaling pathway_Homo sapiens_hsa046622.13089596
7Hippo signaling pathway_Homo sapiens_hsa043902.09422781
8Spliceosome_Homo sapiens_hsa030401.98943833
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95439400
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.95374028
11Mismatch repair_Homo sapiens_hsa034301.94324778
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93362914
13mTOR signaling pathway_Homo sapiens_hsa041501.88671523
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.88545138
15Basal cell carcinoma_Homo sapiens_hsa052171.74262517
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.72085282
17Oocyte meiosis_Homo sapiens_hsa041141.70339721
18Adherens junction_Homo sapiens_hsa045201.68648430
19MicroRNAs in cancer_Homo sapiens_hsa052061.67119036
20TGF-beta signaling pathway_Homo sapiens_hsa043501.62004880
21Hedgehog signaling pathway_Homo sapiens_hsa043401.61663558
22Chemokine signaling pathway_Homo sapiens_hsa040621.61318836
23Platelet activation_Homo sapiens_hsa046111.61025219
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.60721557
25Colorectal cancer_Homo sapiens_hsa052101.60661890
26DNA replication_Homo sapiens_hsa030301.54385080
27Leishmaniasis_Homo sapiens_hsa051401.52633437
28Malaria_Homo sapiens_hsa051441.51410417
29TNF signaling pathway_Homo sapiens_hsa046681.47672338
30Renal cell carcinoma_Homo sapiens_hsa052111.47368168
31Endometrial cancer_Homo sapiens_hsa052131.45824797
32Thyroid cancer_Homo sapiens_hsa052161.45648509
33T cell receptor signaling pathway_Homo sapiens_hsa046601.43836104
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43686743
35Tight junction_Homo sapiens_hsa045301.41501282
36RNA polymerase_Homo sapiens_hsa030201.40943165
37Measles_Homo sapiens_hsa051621.35400850
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34467744
39Dorso-ventral axis formation_Homo sapiens_hsa043201.34335229
40Hepatitis B_Homo sapiens_hsa051611.33545226
41Chronic myeloid leukemia_Homo sapiens_hsa052201.30802555
42Prostate cancer_Homo sapiens_hsa052151.30236502
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29545726
44RNA degradation_Homo sapiens_hsa030181.29482757
45Wnt signaling pathway_Homo sapiens_hsa043101.29358645
46Tuberculosis_Homo sapiens_hsa051521.27355244
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.27298076
48One carbon pool by folate_Homo sapiens_hsa006701.25438164
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23551752
50p53 signaling pathway_Homo sapiens_hsa041151.19326884
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19137657
52Basal transcription factors_Homo sapiens_hsa030221.19048914
53Legionellosis_Homo sapiens_hsa051341.18805787
54Hepatitis C_Homo sapiens_hsa051601.18162996
55Proteoglycans in cancer_Homo sapiens_hsa052051.13547481
56Small cell lung cancer_Homo sapiens_hsa052221.11721987
57Fanconi anemia pathway_Homo sapiens_hsa034601.09359790
58Influenza A_Homo sapiens_hsa051641.07698886
59Bladder cancer_Homo sapiens_hsa052191.06245898
60Nucleotide excision repair_Homo sapiens_hsa034201.05856604
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05845997
62Estrogen signaling pathway_Homo sapiens_hsa049151.03482685
63African trypanosomiasis_Homo sapiens_hsa051431.03409789
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02886705
65Toxoplasmosis_Homo sapiens_hsa051451.02787881
66Viral carcinogenesis_Homo sapiens_hsa052031.01719797
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01657753
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00812258
69Hematopoietic cell lineage_Homo sapiens_hsa046400.98945682
70Pathways in cancer_Homo sapiens_hsa052000.97851969
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96065038
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95280219
73Glioma_Homo sapiens_hsa052140.95209207
74Long-term potentiation_Homo sapiens_hsa047200.94588551
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.94455628
76ErbB signaling pathway_Homo sapiens_hsa040120.94047124
77HTLV-I infection_Homo sapiens_hsa051660.93459774
78Non-small cell lung cancer_Homo sapiens_hsa052230.93023635
79Base excision repair_Homo sapiens_hsa034100.92147922
80Notch signaling pathway_Homo sapiens_hsa043300.92002281
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91348878
82Focal adhesion_Homo sapiens_hsa045100.91152918
83Melanogenesis_Homo sapiens_hsa049160.89856170
84Pancreatic cancer_Homo sapiens_hsa052120.88580869
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88212425
86Melanoma_Homo sapiens_hsa052180.85990472
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.85566901
88Shigellosis_Homo sapiens_hsa051310.84862295
89Gap junction_Homo sapiens_hsa045400.81317985
90Salmonella infection_Homo sapiens_hsa051320.81289049
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81271934
92Type II diabetes mellitus_Homo sapiens_hsa049300.81122453
93VEGF signaling pathway_Homo sapiens_hsa043700.80768738
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80244518
95Herpes simplex infection_Homo sapiens_hsa051680.80031602
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80026542
97FoxO signaling pathway_Homo sapiens_hsa040680.79056819
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78044047
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.77291662
100Pertussis_Homo sapiens_hsa051330.76442038
101Axon guidance_Homo sapiens_hsa043600.76424909
102Rap1 signaling pathway_Homo sapiens_hsa040150.76279008
103Non-homologous end-joining_Homo sapiens_hsa034500.75516410
104Rheumatoid arthritis_Homo sapiens_hsa053230.74856830
105Epstein-Barr virus infection_Homo sapiens_hsa051690.74679912
106MAPK signaling pathway_Homo sapiens_hsa040100.73298733
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.71940179
108Staphylococcus aureus infection_Homo sapiens_hsa051500.70594402
109Choline metabolism in cancer_Homo sapiens_hsa052310.70451412
110Homologous recombination_Homo sapiens_hsa034400.69902591
111Apoptosis_Homo sapiens_hsa042100.69525454
112Long-term depression_Homo sapiens_hsa047300.68438171
113ECM-receptor interaction_Homo sapiens_hsa045120.68097353
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67871258
115Phagosome_Homo sapiens_hsa041450.65227883
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64468234
117Acute myeloid leukemia_Homo sapiens_hsa052210.63906398
118Endocytosis_Homo sapiens_hsa041440.62989258
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.62916388
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62899904
121Vitamin B6 metabolism_Homo sapiens_hsa007500.60826088
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60085339
123GnRH signaling pathway_Homo sapiens_hsa049120.59823117
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58404842
125Inositol phosphate metabolism_Homo sapiens_hsa005620.57845516
126Prion diseases_Homo sapiens_hsa050200.56281542
127Alcoholism_Homo sapiens_hsa050340.56119512
128AMPK signaling pathway_Homo sapiens_hsa041520.55893732
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55884745
130Insulin signaling pathway_Homo sapiens_hsa049100.55250417
131Lysine degradation_Homo sapiens_hsa003100.54590334
132Prolactin signaling pathway_Homo sapiens_hsa049170.54513761
133Dopaminergic synapse_Homo sapiens_hsa047280.53896421
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.53271066
135Ras signaling pathway_Homo sapiens_hsa040140.52627745
136Amoebiasis_Homo sapiens_hsa051460.51485574
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.50639727
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50448949
139Amphetamine addiction_Homo sapiens_hsa050310.49234606
140HIF-1 signaling pathway_Homo sapiens_hsa040660.45751069
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45099978
142Insulin resistance_Homo sapiens_hsa049310.44335569
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43395374
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42514428

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