RYK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.51079767
2collagen fibril organization (GO:0030199)4.37788280
3protein heterotrimerization (GO:0070208)4.25207528
4chondrocyte proliferation (GO:0035988)4.17048751
5paraxial mesoderm development (GO:0048339)4.03988583
6hippo signaling (GO:0035329)3.88843626
7nuclear pore organization (GO:0006999)3.87642627
8skin morphogenesis (GO:0043589)3.78276216
9bone trabecula formation (GO:0060346)3.69840762
10hemidesmosome assembly (GO:0031581)3.69298505
11mitotic sister chromatid cohesion (GO:0007064)3.69232034
12polarized epithelial cell differentiation (GO:0030859)3.59785651
13negative regulation of DNA repair (GO:0045738)3.59762098
14regulation of hippo signaling (GO:0035330)3.57123325
15planar cell polarity pathway involved in neural tube closure (GO:0090179)3.47300772
16embryonic foregut morphogenesis (GO:0048617)3.44896838
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.38053141
18endodermal cell differentiation (GO:0035987)3.31253077
19bundle of His cell to Purkinje myocyte communication (GO:0086069)3.31018285
20G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.25988614
21epithelial cell-cell adhesion (GO:0090136)3.25360110
22desmosome organization (GO:0002934)3.15681757
23negative regulation of catenin import into nucleus (GO:0035414)3.11690886
24mesenchymal-epithelial cell signaling (GO:0060638)3.08245857
25notochord development (GO:0030903)3.05947088
26craniofacial suture morphogenesis (GO:0097094)3.04747910
27endocardial cushion development (GO:0003197)3.02121725
28outer ear morphogenesis (GO:0042473)3.01800944
29plasma membrane repair (GO:0001778)3.01562634
30sequestering of extracellular ligand from receptor (GO:0035581)3.01248242
31negative regulation of keratinocyte proliferation (GO:0010839)3.00212154
32cell migration involved in sprouting angiogenesis (GO:0002042)2.99574446
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.99073216
34mitotic chromosome condensation (GO:0007076)2.97556298
35basement membrane organization (GO:0071711)2.95925979
36cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.90855195
37pore complex assembly (GO:0046931)2.89872990
38negative regulation of chondrocyte differentiation (GO:0032331)2.88695545
39gap junction assembly (GO:0016264)2.88338315
40metanephric mesenchyme development (GO:0072075)2.88332203
41axon extension involved in axon guidance (GO:0048846)2.86804478
42neuron projection extension involved in neuron projection guidance (GO:1902284)2.86804478
43cell adhesion mediated by integrin (GO:0033627)2.86400945
44respiratory tube development (GO:0030323)2.86312442
45cellular protein complex localization (GO:0034629)2.86225847
46glomerular basement membrane development (GO:0032836)2.83083154
47regulation of heart morphogenesis (GO:2000826)2.81524053
48anterior/posterior axis specification, embryo (GO:0008595)2.81364425
49cell-substrate junction assembly (GO:0007044)2.80192221
50kidney mesenchyme development (GO:0072074)2.79748485
51negative regulation of fatty acid transport (GO:2000192)2.78253226
52cranial suture morphogenesis (GO:0060363)2.77743808
53peptidyl-proline hydroxylation (GO:0019511)2.76714036
54establishment of apical/basal cell polarity (GO:0035089)2.76339871
55convergent extension (GO:0060026)2.74883363
56mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.73694009
57regulation of cardioblast differentiation (GO:0051890)2.73577101
58lung-associated mesenchyme development (GO:0060484)2.73488251
59regulation of catenin import into nucleus (GO:0035412)2.72424597
60regulation of SMAD protein import into nucleus (GO:0060390)2.72021485
61morphogenesis of an epithelial sheet (GO:0002011)2.72000388
62collagen metabolic process (GO:0032963)2.71841148
63dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.71695421
64positive regulation of catenin import into nucleus (GO:0035413)2.70640120
65mesenchyme development (GO:0060485)2.70452515
66endothelial cell morphogenesis (GO:0001886)2.68213266
67regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.65017483
68regulation of transforming growth factor beta2 production (GO:0032909)2.64736282
69wound healing, spreading of epidermal cells (GO:0035313)2.64515004
70regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.64351331
71protein localization to cell surface (GO:0034394)2.63415531
72collagen catabolic process (GO:0030574)2.62181079
73organ induction (GO:0001759)2.61446720
74heterochromatin organization (GO:0070828)2.60628073
75chondrocyte development (GO:0002063)2.60619656
76insulin-like growth factor receptor signaling pathway (GO:0048009)2.59645058
77multicellular organismal macromolecule metabolic process (GO:0044259)2.58813694
78positive regulation of endothelial cell apoptotic process (GO:2000353)2.57142842
79regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.57057487
80regulation of RNA export from nucleus (GO:0046831)2.57007811
81negative regulation of embryonic development (GO:0045992)2.56900312
82atrioventricular valve morphogenesis (GO:0003181)2.55928698
83embryonic skeletal joint morphogenesis (GO:0060272)2.55491199
84positive regulation of SMAD protein import into nucleus (GO:0060391)2.55376172
85adherens junction assembly (GO:0034333)2.54626310
86embryonic cranial skeleton morphogenesis (GO:0048701)2.54531891
87axis elongation (GO:0003401)2.53746374
88Golgi transport vesicle coating (GO:0048200)2.53447058
89COPI coating of Golgi vesicle (GO:0048205)2.53447058
90positive regulation of epithelial to mesenchymal transition (GO:0010718)2.53037646
91positive regulation of hormone biosynthetic process (GO:0046886)2.52755082
92protein hydroxylation (GO:0018126)2.52611367
93extracellular matrix disassembly (GO:0022617)2.52408873
94COPII vesicle coating (GO:0048208)2.51617297
95atrial septum morphogenesis (GO:0060413)2.50983215
96mesodermal cell differentiation (GO:0048333)2.50837416
97positive regulation of cartilage development (GO:0061036)2.50712665
98negative regulation of fibroblast apoptotic process (GO:2000270)2.50058055
99multicellular organismal metabolic process (GO:0044236)2.49967424
100regulation of tight junction assembly (GO:2000810)2.49877916
101NLS-bearing protein import into nucleus (GO:0006607)2.49835040
102regulation of sister chromatid cohesion (GO:0007063)2.49374056
103regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.49352806
104protein complex localization (GO:0031503)2.48443650
105branching involved in salivary gland morphogenesis (GO:0060445)2.47115150
106retina vasculature morphogenesis in camera-type eye (GO:0061299)2.46927018
107positive regulation of mesenchymal cell proliferation (GO:0002053)2.46542687
108multicellular organismal catabolic process (GO:0044243)2.46469157
109gastrulation with mouth forming second (GO:0001702)2.46218245
110establishment of planar polarity (GO:0001736)2.45680087
111establishment of tissue polarity (GO:0007164)2.45680087
112dorsal/ventral axis specification (GO:0009950)2.45468910
113middle ear morphogenesis (GO:0042474)2.44044253
114hypotonic response (GO:0006971)2.43056738
115focal adhesion assembly (GO:0048041)2.42637102
116cell-substrate adherens junction assembly (GO:0007045)2.42637102
117positive regulation of fatty acid beta-oxidation (GO:0032000)2.42478146
118negative regulation of cartilage development (GO:0061037)2.41774426
119cochlea morphogenesis (GO:0090103)2.41396764
120epoxygenase P450 pathway (GO:0019373)2.41203362
121regulation of cell fate specification (GO:0042659)2.40792205
122non-canonical Wnt signaling pathway (GO:0035567)2.39624219
123midgut development (GO:0007494)2.37965045
124Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.37454254
125renal filtration (GO:0097205)2.37162309
126regulation of mesenchymal cell proliferation (GO:0010464)2.36823563
127regulation of establishment of planar polarity (GO:0090175)2.36601196
128mitotic metaphase plate congression (GO:0007080)2.36450056
129pattern specification involved in kidney development (GO:0061004)2.36382784
130lateral sprouting from an epithelium (GO:0060601)2.35243947
1314-hydroxyproline metabolic process (GO:0019471)2.33756157
132regulation of gastrulation (GO:0010470)2.33634586
133regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.33608826
134cell surface receptor signaling pathway involved in heart development (GO:0061311)2.33504448
135negative regulation of cell fate specification (GO:0009996)2.31071701
136pericardium development (GO:0060039)2.28321621
137regulation of nucleobase-containing compound transport (GO:0032239)2.28020871
138regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.28005503
139DNA unwinding involved in DNA replication (GO:0006268)2.25358688
140pre-miRNA processing (GO:0031054)2.24823816
141endoderm development (GO:0007492)2.23582630
142metaphase plate congression (GO:0051310)2.23473811
143regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.22283008
144establishment of monopolar cell polarity (GO:0061162)2.19694162
145establishment or maintenance of monopolar cell polarity (GO:0061339)2.19694162
146regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.19263861
147negative regulation of stem cell proliferation (GO:2000647)2.17150346
148glomerular visceral epithelial cell development (GO:0072015)2.14838028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.69834190
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.76764932
3E2F7_22180533_ChIP-Seq_HELA_Human4.64531240
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.39582628
5CLOCK_20551151_ChIP-Seq_293T_Human3.22175338
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.09960990
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.43438972
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41603646
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.23155946
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.11087939
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.10596964
12* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.01243844
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00292728
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.00034213
15WT1_19549856_ChIP-ChIP_CCG9911_Human1.97380198
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97145548
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96989145
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.96581643
19ZNF263_19887448_ChIP-Seq_K562_Human1.95414509
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90971987
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90490954
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90317043
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.89096654
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.88514417
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.81394025
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80983261
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.80705955
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77990266
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77924878
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.77680524
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.73883240
32* CJUN_26792858_Chip-Seq_BT549_Human1.72486386
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.72389523
34AR_21909140_ChIP-Seq_LNCAP_Human1.71541846
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70133938
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68854334
37BRD4_25478319_ChIP-Seq_HGPS_Human1.67209028
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66975048
39TCF3_18692474_ChIP-Seq_MEFs_Mouse1.65614339
40* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64410711
41ATF3_27146783_Chip-Seq_COLON_Human1.63374447
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.63152454
43* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.60420464
44* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.60420464
45SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59415131
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59091837
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58715654
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56266746
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56239432
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55335200
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53543788
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51967013
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51596006
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.49547041
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.47774231
56UBF1/2_26484160_Chip-Seq_HMECs_Human1.47046833
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46016210
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45938427
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45938427
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45938427
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45825146
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.45062265
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.44182920
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.43833682
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41429919
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.40885281
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37861062
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37014017
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30510134
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29421119
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29329522
72EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28784639
73RACK7_27058665_Chip-Seq_MCF-7_Human1.26629609
74SOX17_20123909_ChIP-Seq_XEN_Mouse1.25701861
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24754125
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.22411843
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21880877
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21445650
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20966419
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18190379
81SOX2_20726797_ChIP-Seq_SW620_Human1.17194175
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17039433
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16767728
84RXR_22158963_ChIP-Seq_LIVER_Mouse1.15941717
85MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14625927
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13392716
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13392716
88LXR_22158963_ChIP-Seq_LIVER_Mouse1.13253615
89FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11491223
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.10960294
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.10960294
92TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10404742
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.10061312
94CHD1_26751641_Chip-Seq_LNCaP_Human1.08902550
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08822350
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08228295
97PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08082973
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.07933116
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07826972
100P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07811996
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06185417
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.05249380
103TP53_22127205_ChIP-Seq_IMR90_Human1.03398052
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03061900
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02395690
106* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00854994
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.00579236
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00467261
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00346318
110NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00251269
111TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99697771
112ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99179984
113TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98215247
114SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97601504
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97158466
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96786001
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96685749
118AHR_22903824_ChIP-Seq_MCF-7_Human0.96648147
119ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96446361
120FUS_26573619_Chip-Seq_HEK293_Human0.95858688
121TCF4_18268006_ChIP-ChIP_LS174T_Human0.95168740
122GATA4_21415370_ChIP-Seq_HL-1_Mouse0.94840860
123NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94042154
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.93846946
125NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93661299
126GATA4_25053715_ChIP-Seq_YYC3_Human0.93485798
127GATA3_24758297_ChIP-Seq_MCF-7_Human0.92979738
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92721888
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92350939
130TP53_18474530_ChIP-ChIP_U2OS_Human0.92242462
131TP53_16413492_ChIP-PET_HCT116_Human0.92140624
132TP63_19390658_ChIP-ChIP_HaCaT_Human0.91968517
133MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91663987

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.26609710
2MP0003705_abnormal_hypodermis_morpholog4.23236493
3MP0005275_abnormal_skin_tensile3.93645160
4MP0005503_abnormal_tendon_morphology3.09970924
5MP0010030_abnormal_orbit_morphology2.79928564
6MP0004272_abnormal_basement_membrane2.61281451
7MP0005623_abnormal_meninges_morphology2.57050044
8MP0009053_abnormal_anal_canal2.28223086
9MP0009384_cardiac_valve_regurgitation2.26315723
10MP0000537_abnormal_urethra_morphology2.13799449
11MP0002060_abnormal_skin_morphology1.99671787
12MP0009250_abnormal_appendicular_skeleto1.93647169
13MP0003941_abnormal_skin_development1.93009676
14MP0003385_abnormal_body_wall1.88937643
15MP0001958_emphysema1.86960084
16MP0010352_gastrointestinal_tract_polyps1.77770969
17MP0003566_abnormal_cell_adhesion1.77125728
18MP0005508_abnormal_skeleton_morphology1.75561357
19MP0003279_aneurysm1.74140244
20MP0010234_abnormal_vibrissa_follicle1.73993131
21MP0008057_abnormal_DNA_replication1.68150479
22MP0004957_abnormal_blastocyst_morpholog1.65578045
23MP0003937_abnormal_limbs/digits/tail_de1.64246584
24MP0002796_impaired_skin_barrier1.62985993
25MP0004185_abnormal_adipocyte_glucose1.60958437
26MP0005257_abnormal_intraocular_pressure1.57694159
27MP0000733_abnormal_muscle_development1.56590140
28MP0003942_abnormal_urinary_system1.55301468
29MP0002249_abnormal_larynx_morphology1.54013806
30MP0003890_abnormal_embryonic-extraembry1.50769899
31MP0009379_abnormal_foot_pigmentation1.43956047
32MP0002877_abnormal_melanocyte_morpholog1.42010787
33MP0002896_abnormal_bone_mineralization1.41686717
34MP0005023_abnormal_wound_healing1.39435677
35MP0002282_abnormal_trachea_morphology1.39321708
36MP0006054_spinal_hemorrhage1.35865074
37* MP0003755_abnormal_palate_morphology1.35531494
38MP0000534_abnormal_ureter_morphology1.33927250
39MP0000428_abnormal_craniofacial_morphol1.33048093
40* MP0000762_abnormal_tongue_morphology1.31191604
41MP0001299_abnormal_eye_distance/1.29557517
42MP0002108_abnormal_muscle_morphology1.28756987
43MP0003115_abnormal_respiratory_system1.27638126
44MP0002932_abnormal_joint_morphology1.27394461
45MP0003283_abnormal_digestive_organ1.24643352
46MP0003984_embryonic_growth_retardation1.21360901
47MP0001672_abnormal_embryogenesis/_devel1.19164615
48MP0005380_embryogenesis_phenotype1.19164615
49MP0002295_abnormal_pulmonary_circulatio1.18914260
50MP0005501_abnormal_skin_physiology1.18718599
51MP0002088_abnormal_embryonic_growth/wei1.18219811
52MP0003935_abnormal_craniofacial_develop1.15208107
53MP0000467_abnormal_esophagus_morphology1.14250050
54MP0010368_abnormal_lymphatic_system1.13790363
55MP0000579_abnormal_nail_morphology1.13327443
56MP0001730_embryonic_growth_arrest1.11733908
57MP0002086_abnormal_extraembryonic_tissu1.11142097
58MP0000049_abnormal_middle_ear1.10673917
59MP0001286_abnormal_eye_development1.10581805
60MP0001849_ear_inflammation1.10209054
61* MP0000432_abnormal_head_morphology1.10059853
62MP0009697_abnormal_copulation1.09672279
63MP0002009_preneoplasia1.08787651
64MP0008932_abnormal_embryonic_tissue1.08703746
65MP0003091_abnormal_cell_migration1.08693400
66MP0002233_abnormal_nose_morphology1.07789660
67MP0000163_abnormal_cartilage_morphology1.06920523
68MP0001661_extended_life_span1.06899049
69MP0001243_abnormal_dermal_layer1.06503555
70MP0010678_abnormal_skin_adnexa1.05613545
71MP0005367_renal/urinary_system_phenotyp1.04115731
72MP0000516_abnormal_urinary_system1.04115731
73MP0002111_abnormal_tail_morphology1.04070515
74MP0005076_abnormal_cell_differentiation1.02776861
75MP0009672_abnormal_birth_weight1.02274402
76MP0001293_anophthalmia1.02101791
77MP0004264_abnormal_extraembryonic_tissu1.01865570
78MP0004134_abnormal_chest_morphology1.01433174
79MP0001697_abnormal_embryo_size1.01312092
80MP0002234_abnormal_pharynx_morphology1.00941095
81MP0001915_intracranial_hemorrhage1.00772640
82MP0004197_abnormal_fetal_growth/weight/0.98757835
83MP0005666_abnormal_adipose_tissue0.98595082
84MP0000350_abnormal_cell_proliferation0.98078662
85MP0000750_abnormal_muscle_regeneration0.97632328
86MP0003077_abnormal_cell_cycle0.97470902
87MP0005197_abnormal_uvea_morphology0.97430986
88MP0005248_abnormal_Harderian_gland0.96471363
89MP0009703_decreased_birth_body0.95920555
90MP0001879_abnormal_lymphatic_vessel0.94532806
91MP0003119_abnormal_digestive_system0.94080013
92MP0003315_abnormal_perineum_morphology0.93960866
93MP0000377_abnormal_hair_follicle0.93915636
94MP0002925_abnormal_cardiovascular_devel0.93894888
95MP0003453_abnormal_keratinocyte_physiol0.93579596
96MP0002084_abnormal_developmental_patter0.93243420
97* MP0002115_abnormal_skeleton_extremities0.92649941
98MP0004233_abnormal_muscle_weight0.91774145
99MP0000383_abnormal_hair_follicle0.91192322
100* MP0002697_abnormal_eye_size0.90725836
101* MP0002116_abnormal_craniofacial_bone0.90446316
102MP0000462_abnormal_digestive_system0.90404760
103MP0003111_abnormal_nucleus_morphology0.89820732
104MP0000627_abnormal_mammary_gland0.88934559
105MP0000647_abnormal_sebaceous_gland0.88856862
106MP0010630_abnormal_cardiac_muscle0.88514611
107MP0005375_adipose_tissue_phenotype0.88251807
108MP0000767_abnormal_smooth_muscle0.87051550
109MP0002098_abnormal_vibrissa_morphology0.86710787
110MP0000003_abnormal_adipose_tissue0.86150109
111MP0010771_integument_phenotype0.86139281
112MP0003123_paternal_imprinting0.85817048
113MP0002168_other_aberrant_phenotype0.85709752
114MP0005409_darkened_coat_color0.85256362
115MP0000751_myopathy0.84534828
116MP0001346_abnormal_lacrimal_gland0.84290362
117MP0002085_abnormal_embryonic_tissue0.83639083
118MP0002080_prenatal_lethality0.82710378
119MP0010307_abnormal_tumor_latency0.82433165
120MP0002092_abnormal_eye_morphology0.82383642
121MP0001340_abnormal_eyelid_morphology0.81998204
122* MP0002109_abnormal_limb_morphology0.80956157
123MP0001542_abnormal_bone_strength0.80816653
124MP0003567_abnormal_fetal_cardiomyocyte0.80459913
125MP0004087_abnormal_muscle_fiber0.79549824
126MP0004084_abnormal_cardiac_muscle0.77236819
127MP0002177_abnormal_outer_ear0.75803960
128MP0000566_synostosis0.75273001
129MP0003950_abnormal_plasma_membrane0.75105577
130MP0006138_congestive_heart_failure0.75050309
131MP0002114_abnormal_axial_skeleton0.74683316
132MP0001216_abnormal_epidermal_layer0.73920539

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.58742619
2Protrusio acetabuli (HP:0003179)6.26243726
3Shallow orbits (HP:0000586)4.38119069
4Atrophic scars (HP:0001075)4.16971289
5Ankle contracture (HP:0006466)3.77777742
6Aortic dissection (HP:0002647)3.51524359
7Soft skin (HP:0000977)3.31953384
8Vascular tortuosity (HP:0004948)3.18383944
9Peritonitis (HP:0002586)3.17322595
10Arterial tortuosity (HP:0005116)3.16227915
11Fragile skin (HP:0001030)3.11496893
12Neonatal short-limb short stature (HP:0008921)3.09812904
13Abnormality of dentin (HP:0010299)3.09403478
14Increased connective tissue (HP:0009025)3.00119622
15Broad metatarsal (HP:0001783)2.99440843
16Type 1 muscle fiber predominance (HP:0003803)2.96531263
17Bladder diverticulum (HP:0000015)2.87845961
18Mitral valve prolapse (HP:0001634)2.81100019
19Genu recurvatum (HP:0002816)2.76588236
20Spinal rigidity (HP:0003306)2.75443262
21Coronal craniosynostosis (HP:0004440)2.73424678
22Cervical subluxation (HP:0003308)2.68097338
23Aortic aneurysm (HP:0004942)2.67672538
24Wrist flexion contracture (HP:0001239)2.65231635
25Cerebral aneurysm (HP:0004944)2.64578902
26Dilatation of the ascending aorta (HP:0005111)2.57311647
27Blue sclerae (HP:0000592)2.56175851
28Overgrowth (HP:0001548)2.46353289
29Ankyloglossia (HP:0010296)2.46316424
30Wormian bones (HP:0002645)2.43617341
31Right ventricular cardiomyopathy (HP:0011663)2.38128879
32Round ear (HP:0100830)2.32659485
33Asymmetry of the thorax (HP:0001555)2.30154129
34Wide anterior fontanel (HP:0000260)2.29654499
35Spinal cord lesions (HP:0100561)2.29551693
36Syringomyelia (HP:0003396)2.29551693
37Mildly elevated creatine phosphokinase (HP:0008180)2.29454615
38Follicular hyperkeratosis (HP:0007502)2.27824260
39Abnormal delivery (HP:0001787)2.23523431
40Vertebral arch anomaly (HP:0008438)2.23223713
41Hyperextensible skin (HP:0000974)2.17485370
42Deviation of the hallux (HP:0010051)2.15799824
43Scapular winging (HP:0003691)2.15039320
44Buphthalmos (HP:0000557)2.14150556
45Missing ribs (HP:0000921)2.12803625
46Increased variability in muscle fiber diameter (HP:0003557)2.10979882
47Bronchomalacia (HP:0002780)2.08343268
48Hallux valgus (HP:0001822)2.05956409
49Infantile muscular hypotonia (HP:0008947)2.04686952
50Bell-shaped thorax (HP:0001591)2.03738234
51Abnormality of oral frenula (HP:0000190)2.02677649
52Abnormality of the calcaneus (HP:0008364)2.02150678
53Natal tooth (HP:0000695)2.02122183
54Elbow flexion contracture (HP:0002987)2.00408737
55Ulnar bowing (HP:0003031)1.99513868
56Tibial bowing (HP:0002982)1.97586443
57Biconcave vertebral bodies (HP:0004586)1.97420695
58Hypoplastic ischia (HP:0003175)1.96484410
59Short nail (HP:0001799)1.96308453
60Rectal prolapse (HP:0002035)1.96115248
61Difficulty climbing stairs (HP:0003551)1.95680628
62Thin bony cortex (HP:0002753)1.95466747
63Tarsal synostosis (HP:0008368)1.95138933
64Venous abnormality (HP:0002624)1.90602370
65Aneurysm (HP:0002617)1.89844664
66Absent eyelashes (HP:0000561)1.89255540
67Abnormality of the distal phalanx of the thumb (HP:0009617)1.88488004
68Bowel diverticulosis (HP:0005222)1.87982010
69Mesomelia (HP:0003027)1.87951756
70Camptodactyly of toe (HP:0001836)1.87777307
71Absent frontal sinuses (HP:0002688)1.86953065
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85754426
73Microglossia (HP:0000171)1.83395994
74Achilles tendon contracture (HP:0001771)1.81635684
75Short 4th metacarpal (HP:0010044)1.81509113
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81509113
77Abnormality of the acetabulum (HP:0003170)1.80766538
78Abnormality of carpal bone ossification (HP:0006257)1.80236390
79Vertebral compression fractures (HP:0002953)1.80210388
80Deviation of the thumb (HP:0009603)1.80157484
81Back pain (HP:0003418)1.80018412
82Aplasia involving bones of the upper limbs (HP:0009823)1.78733508
83Aplasia of the phalanges of the hand (HP:0009802)1.78733508
84Aplasia involving bones of the extremities (HP:0009825)1.78733508
85Abnormality of skeletal muscle fiber size (HP:0012084)1.78044549
86Abnormality of the 4th metacarpal (HP:0010012)1.77979521
87Vertebral hypoplasia (HP:0008417)1.77266324
88Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77266324
89Abnormality of the 2nd finger (HP:0004100)1.76524143
90Knee flexion contracture (HP:0006380)1.76498301
91Muscle fiber splitting (HP:0003555)1.76230959
92Turricephaly (HP:0000262)1.74665948
93Hyporeflexia of lower limbs (HP:0002600)1.74632608
94Abnormality of the ischium (HP:0003174)1.74023836
95Delayed cranial suture closure (HP:0000270)1.73615446
96Venous insufficiency (HP:0005293)1.72906686
97Synostosis involving bones of the feet (HP:0009140)1.72719387
98Synostosis involving bones of the lower limbs (HP:0009138)1.72719387
99Pterygium (HP:0001059)1.72671719
100Abnormality of the Achilles tendon (HP:0005109)1.72162136
101Broad ribs (HP:0000885)1.71383787
102Flat acetabular roof (HP:0003180)1.71222250
103Synostosis of carpal bones (HP:0005048)1.70656251
104Short hallux (HP:0010109)1.69964128
105Abnormality of the umbilical cord (HP:0010881)1.69434584
106Calcaneovalgus deformity (HP:0001848)1.68958845
107Broad long bones (HP:0005622)1.68065873
108Mitral regurgitation (HP:0001653)1.68008886
109Advanced eruption of teeth (HP:0006288)1.65968969
110Hip contracture (HP:0003273)1.65264068
111Partial duplication of the phalanx of hand (HP:0009999)1.64116943
112Congenital glaucoma (HP:0001087)1.64106815
113Selective tooth agenesis (HP:0001592)1.63835928
114Abnormal ossification of hand bones (HP:0005921)1.63830557
115Malignant gastrointestinal tract tumors (HP:0006749)1.63386033
116Gastrointestinal carcinoma (HP:0002672)1.63386033
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.62120848
118Osteolytic defects of the hand bones (HP:0009699)1.62120848
119Abnormality of the distal phalanges of the toes (HP:0010182)1.62106184
120Abnormal ventriculo-arterial connection (HP:0011563)1.61931083
121Transposition of the great arteries (HP:0001669)1.61931083
122Abnormal connection of the cardiac segments (HP:0011545)1.61931083
123Milia (HP:0001056)1.61860676
124Deformed tarsal bones (HP:0008119)1.61616234
125Morphological abnormality of the middle ear (HP:0008609)1.61326259
126Breech presentation (HP:0001623)1.61157132
127Fragile nails (HP:0001808)1.61087081
128Papillary thyroid carcinoma (HP:0002895)1.61072572
129Femoral bowing (HP:0002980)1.61001867
130Joint laxity (HP:0001388)1.60691610
131Insidious onset (HP:0003587)1.59874162
132Termporal pattern (HP:0011008)1.59874162
133Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.58697179
134Deep philtrum (HP:0002002)1.58311468
135Limited hip movement (HP:0008800)1.57340493
136Cutaneous finger syndactyly (HP:0010554)1.54166136
137Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.53829967
138Proximal placement of thumb (HP:0009623)1.53788693
139Disproportionate tall stature (HP:0001519)1.53383598
140Abnormality of the phalanges of the hallux (HP:0010057)1.52807184
141Arnold-Chiari malformation (HP:0002308)1.52133982
142Abnormality of the fetal cardiovascular system (HP:0010948)1.51947071
143Abnormal umbilical cord blood vessels (HP:0011403)1.51947071
144Single umbilical artery (HP:0001195)1.51947071
145Abnormality of the nasolacrimal system (HP:0000614)1.51786943
146Cutaneous syndactyly (HP:0012725)1.50664278
147Preaxial foot polydactyly (HP:0001841)1.49746549
148Abnormal vertebral ossification (HP:0100569)1.49368175
149Rhizomelia (HP:0008905)1.49291497
150Skull defect (HP:0001362)1.49223758
151Relative macrocephaly (HP:0004482)1.48803173
152Pulmonic stenosis (HP:0001642)1.48525172
153Nephroblastoma (Wilms tumor) (HP:0002667)1.47942900
154Thin ribs (HP:0000883)1.47907592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.66417782
2TRIB34.05225538
3DDR23.30629408
4TTN3.19209887
5LATS23.02515523
6EPHB22.81397272
7PKN22.67190481
8PDGFRA2.64941670
9EPHA22.56106292
10FER2.19886672
11STK38L2.16286828
12PBK2.03912840
13MET1.97162769
14BRSK21.89568370
15SIK11.72022999
16STK31.63508562
17STK241.62394923
18PTK61.58258250
19SCYL21.52994433
20PNCK1.49129480
21PTK21.49086691
22RIPK11.46474435
23PAK21.43722720
24AKT31.41511157
25CDC71.41031722
26MYLK1.40266201
27PAK31.36327933
28TAF11.35969271
29FLT31.34904997
30BMX1.31622946
31TSSK61.28465623
32SMG11.27744833
33LRRK21.20646979
34BRD41.20318471
35PAK41.19783715
36DMPK1.19084218
37FGFR21.18796460
38EPHA31.17668757
39MTOR1.17007634
40MKNK11.16394621
41NTRK11.15934762
42FGFR11.14915727
43ILK1.14444316
44WEE11.12034456
45MKNK21.08526650
46CDK121.07758981
47PRKD31.07758302
48MAP3K31.07521086
49SRPK11.06416106
50RPS6KA41.04293063
51EEF2K1.04261479
52PIK3CA1.00446327
53TGFBR11.00042210
54MST1R0.99881655
55LIMK10.97727280
56LMTK20.97726353
57FRK0.95089272
58PDGFRB0.93100226
59ROCK10.92551400
60ERBB40.91772275
61PLK40.91663885
62PLK30.86073549
63TTK0.85544068
64NEK90.84599687
65TYRO30.83146958
66CDK60.82416685
67MELK0.81966184
68EPHB10.81864958
69MOS0.81400333
70ERN10.81214467
71RPS6KB20.80755696
72NEK20.80660903
73EIF2AK30.79961092
74CDK90.79628379
75BUB10.75932894
76NLK0.75173074
77BCKDK0.73973558
78TRPM70.69836335
79CAMK1D0.69272389
80WNK40.69216022
81YES10.69061148
82MAP2K10.68754481
83ERBB20.68556686
84MAP3K80.68522280
85CHEK20.68432240
86DYRK1B0.64350700
87EIF2AK10.64184369
88ICK0.64093245
89DYRK30.63816734
90NEK10.63569805
91MAP3K60.61617957
92PRKD20.61038625
93FGFR30.60415787
94MAP2K20.60047312
95PLK10.59271053
96PRKD10.58179989
97ROCK20.57928406
98GSK3A0.57860683
99RET0.56962632
100CHEK10.55712134
101AURKB0.55296852
102CDK40.51986791
103CDK80.50847455
104AKT20.50284331
105NUAK10.50131171
106FGFR40.49140264
107MAP3K100.48219028
108NEK60.46719110
109DYRK20.45808947
110BRSK10.45594084
111MST40.45314786
112ACVR1B0.45245564
113STK380.43120466
114PRKCI0.41533289
115ABL20.41171172
116MAPKAPK30.40787173
117STK40.40181852
118ERBB30.38947292
119TGFBR20.38731364
120PIK3CG0.37684243
121OBSCN0.37479729
122PAK10.37221190
123ATM0.36918343
124MAP3K120.36150643
125CDK70.36136967
126INSR0.35891628
127CSNK1E0.35622644
128CSNK1G10.35166359
129PRKG20.34833587
130CDC42BPA0.34220840
131TESK10.33731099
132CSNK1A1L0.33238399
133MAP3K20.32843883
134KSR10.32108099
135CAMK1G0.32033723
136STK390.31889443
137AURKA0.31258337
138PASK0.29882852
139TLK10.29026531
140PRKAA20.28168051
141STK100.26904690
142WNK10.25809020
143CSNK1D0.25123767

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.43786212
2Basal cell carcinoma_Homo sapiens_hsa052172.59632704
3Hippo signaling pathway_Homo sapiens_hsa043902.57238322
4Focal adhesion_Homo sapiens_hsa045102.40462891
5Adherens junction_Homo sapiens_hsa045202.27678523
6TGF-beta signaling pathway_Homo sapiens_hsa043502.19185034
7Hedgehog signaling pathway_Homo sapiens_hsa043402.18536748
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.06780924
9Bladder cancer_Homo sapiens_hsa052192.04056590
10Tight junction_Homo sapiens_hsa045302.00747086
11Proteoglycans in cancer_Homo sapiens_hsa052051.98644706
12Protein digestion and absorption_Homo sapiens_hsa049741.88618200
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.87859893
14Nitrogen metabolism_Homo sapiens_hsa009101.83615283
15Small cell lung cancer_Homo sapiens_hsa052221.67710734
16MicroRNAs in cancer_Homo sapiens_hsa052061.66090616
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.56228894
18Non-homologous end-joining_Homo sapiens_hsa034501.48132221
19Amoebiasis_Homo sapiens_hsa051461.44207224
20Dilated cardiomyopathy_Homo sapiens_hsa054141.39334073
21Fatty acid degradation_Homo sapiens_hsa000711.30779816
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27483055
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24618463
24Wnt signaling pathway_Homo sapiens_hsa043101.23164022
25Melanoma_Homo sapiens_hsa052181.23150790
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18928703
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17362924
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17048104
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.15697114
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15694516
31Fatty acid metabolism_Homo sapiens_hsa012121.13351205
32Prostate cancer_Homo sapiens_hsa052151.12128686
33Nucleotide excision repair_Homo sapiens_hsa034201.09943282
34Axon guidance_Homo sapiens_hsa043601.09749377
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05406651
36PPAR signaling pathway_Homo sapiens_hsa033201.05320854
37p53 signaling pathway_Homo sapiens_hsa041151.03474356
38Lysine degradation_Homo sapiens_hsa003101.03039486
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00249136
40Renal cell carcinoma_Homo sapiens_hsa052110.99683771
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99165779
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98430261
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97895616
44AMPK signaling pathway_Homo sapiens_hsa041520.97510954
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97164815
46Mismatch repair_Homo sapiens_hsa034300.96816501
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96268814
48DNA replication_Homo sapiens_hsa030300.96201551
49Butanoate metabolism_Homo sapiens_hsa006500.95574838
50Melanogenesis_Homo sapiens_hsa049160.94279250
51Sulfur metabolism_Homo sapiens_hsa009200.92202591
52Pathways in cancer_Homo sapiens_hsa052000.92122735
53Chronic myeloid leukemia_Homo sapiens_hsa052200.91804525
54Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85818161
55Chemical carcinogenesis_Homo sapiens_hsa052040.85568599
56N-Glycan biosynthesis_Homo sapiens_hsa005100.85150752
57Fat digestion and absorption_Homo sapiens_hsa049750.84705743
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84417980
59Arginine and proline metabolism_Homo sapiens_hsa003300.82825950
60Vitamin B6 metabolism_Homo sapiens_hsa007500.82625659
61Endometrial cancer_Homo sapiens_hsa052130.81576626
62Propanoate metabolism_Homo sapiens_hsa006400.81138759
63Tryptophan metabolism_Homo sapiens_hsa003800.80348669
64Cell cycle_Homo sapiens_hsa041100.79819604
65Selenocompound metabolism_Homo sapiens_hsa004500.78933729
66Thyroid cancer_Homo sapiens_hsa052160.78135734
67One carbon pool by folate_Homo sapiens_hsa006700.76391818
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.76355711
69ErbB signaling pathway_Homo sapiens_hsa040120.76039013
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75978362
71Non-small cell lung cancer_Homo sapiens_hsa052230.75188389
72Spliceosome_Homo sapiens_hsa030400.74911984
73Circadian rhythm_Homo sapiens_hsa047100.74646861
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.73799919
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72927309
76Fatty acid biosynthesis_Homo sapiens_hsa000610.72189621
77Insulin resistance_Homo sapiens_hsa049310.71895849
78Rap1 signaling pathway_Homo sapiens_hsa040150.68552040
79Steroid biosynthesis_Homo sapiens_hsa001000.68364587
80Arginine biosynthesis_Homo sapiens_hsa002200.66580330
81Glioma_Homo sapiens_hsa052140.66382062
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64285845
83Ovarian steroidogenesis_Homo sapiens_hsa049130.64277641
84mTOR signaling pathway_Homo sapiens_hsa041500.64229616
85RNA transport_Homo sapiens_hsa030130.64129730
86Pancreatic cancer_Homo sapiens_hsa052120.63737370
87Caffeine metabolism_Homo sapiens_hsa002320.63638877
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63600239
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62236157
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.61613058
91Glutathione metabolism_Homo sapiens_hsa004800.61380641
92Pyruvate metabolism_Homo sapiens_hsa006200.61032332
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60516823
94HTLV-I infection_Homo sapiens_hsa051660.60487418
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60346820
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60235582
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.58590869
98Choline metabolism in cancer_Homo sapiens_hsa052310.58466176
99Notch signaling pathway_Homo sapiens_hsa043300.57175112
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56716306
101Bile secretion_Homo sapiens_hsa049760.56030612
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55563114
103Biosynthesis of amino acids_Homo sapiens_hsa012300.55110322
104Renin-angiotensin system_Homo sapiens_hsa046140.55020783
105Inositol phosphate metabolism_Homo sapiens_hsa005620.54679931
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54054828
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53889650
108Glucagon signaling pathway_Homo sapiens_hsa049220.52729889
109Complement and coagulation cascades_Homo sapiens_hsa046100.52588744
110mRNA surveillance pathway_Homo sapiens_hsa030150.51652415
111Dorso-ventral axis formation_Homo sapiens_hsa043200.51369491
112Carbon metabolism_Homo sapiens_hsa012000.51359853
113Viral carcinogenesis_Homo sapiens_hsa052030.50276220
114Insulin signaling pathway_Homo sapiens_hsa049100.50171810
115Retinol metabolism_Homo sapiens_hsa008300.50001212
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49959303
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49503706
118Tyrosine metabolism_Homo sapiens_hsa003500.49185996
119FoxO signaling pathway_Homo sapiens_hsa040680.48080756
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.46946581
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.46591989
122Thyroid hormone synthesis_Homo sapiens_hsa049180.46425335
123Colorectal cancer_Homo sapiens_hsa052100.45387512
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.44772519
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44368827
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43948499
127Gap junction_Homo sapiens_hsa045400.41841116
128Sphingolipid metabolism_Homo sapiens_hsa006000.41093210
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38892410
130Galactose metabolism_Homo sapiens_hsa000520.38014278
131Prion diseases_Homo sapiens_hsa050200.36584405
132Pentose phosphate pathway_Homo sapiens_hsa000300.35707503

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