RYKP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.22076167
2nuclear pore organization (GO:0006999)5.08988856
3replicative senescence (GO:0090399)5.08816687
4cytoplasmic mRNA processing body assembly (GO:0033962)4.77790929
5regulation of RNA export from nucleus (GO:0046831)4.63882041
6mitotic sister chromatid cohesion (GO:0007064)4.58999294
7pericardium development (GO:0060039)4.58543061
8pore complex assembly (GO:0046931)4.49285936
9interkinetic nuclear migration (GO:0022027)4.25691675
10phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.16003488
11embryonic process involved in female pregnancy (GO:0060136)4.11055207
12monoubiquitinated protein deubiquitination (GO:0035520)4.08900891
13cellular response to ethanol (GO:0071361)4.07869340
14protein K48-linked deubiquitination (GO:0071108)4.06523789
15regulation of establishment of cell polarity (GO:2000114)4.04180908
16histone H3-K36 demethylation (GO:0070544)4.04026249
17positive regulation of developmental pigmentation (GO:0048087)3.97190917
18peptidyl-lysine trimethylation (GO:0018023)3.90877115
19dosage compensation (GO:0007549)3.73710057
20regulation of nucleobase-containing compound transport (GO:0032239)3.71547434
21detection of molecule of bacterial origin (GO:0032490)3.68480148
22DNA damage induced protein phosphorylation (GO:0006975)3.67499539
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.60719540
24regulation of translation, ncRNA-mediated (GO:0045974)3.60719540
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.60719540
26leukotriene biosynthetic process (GO:0019370)3.53260749
27histone-serine phosphorylation (GO:0035404)3.52741889
28histone H3-K4 trimethylation (GO:0080182)3.46744491
29negative regulation of DNA repair (GO:0045738)3.40705015
30energy homeostasis (GO:0097009)3.38334264
31histone phosphorylation (GO:0016572)3.37499458
32regulation of DNA endoreduplication (GO:0032875)3.37003335
33coronary vasculature morphogenesis (GO:0060977)3.29845715
34regulation of interleukin-12 biosynthetic process (GO:0045075)3.26046718
35negative regulation of cell cycle G2/M phase transition (GO:1902750)3.20803452
36regulation of pigment cell differentiation (GO:0050932)3.16531477
37pre-miRNA processing (GO:0031054)3.13314169
38peptidyl-lysine methylation (GO:0018022)3.12813058
39negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.11423840
40regulation of establishment or maintenance of cell polarity (GO:0032878)3.11087593
41snRNA transcription (GO:0009301)3.06688749
42positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.04728840
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.04326661
44positive regulation by organism of defense response of other organism involved in symbiotic interact3.04326661
45modulation by symbiont of host immune response (GO:0052553)3.04326661
46positive regulation by symbiont of host defense response (GO:0052509)3.04326661
47modulation by symbiont of host defense response (GO:0052031)3.04326661
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.04326661
49hepatocyte apoptotic process (GO:0097284)3.01043657
50Peyers patch development (GO:0048541)3.00047758
51mucosal-associated lymphoid tissue development (GO:0048537)3.00047758
52negative T cell selection (GO:0043383)2.98991809
53histone mRNA catabolic process (GO:0071044)2.96915784
54histone H3-K4 methylation (GO:0051568)2.93127944
55natural killer cell differentiation (GO:0001779)2.92804404
56sister chromatid segregation (GO:0000819)2.92635046
57lipid translocation (GO:0034204)2.91877504
58phospholipid translocation (GO:0045332)2.91877504
59V(D)J recombination (GO:0033151)2.90351031
60protein K11-linked deubiquitination (GO:0035871)2.88372447
61microglial cell activation (GO:0001774)2.87138232
62microtubule nucleation (GO:0007020)2.85596821
63positive regulation of gamma-delta T cell activation (GO:0046645)2.85301852
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.85128732
65DNA unwinding involved in DNA replication (GO:0006268)2.84021136
66positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.83912986
67activation of Rac GTPase activity (GO:0032863)2.82125929
68peptidyl-threonine phosphorylation (GO:0018107)2.80688713
69negative regulation of myotube differentiation (GO:0010832)2.80223157
70T cell lineage commitment (GO:0002360)2.78833426
71corticosteroid receptor signaling pathway (GO:0031958)2.77733090
72protein localization to chromosome, centromeric region (GO:0071459)2.77729047
73macrophage activation involved in immune response (GO:0002281)2.75707915
74embryonic camera-type eye morphogenesis (GO:0048596)2.75225400
75regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.73466453
76positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.73466453
77positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.72107736
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.71537441
79positive regulation of RNA splicing (GO:0033120)2.71032208
80positive regulation of granulocyte differentiation (GO:0030854)2.70912199
81negative thymic T cell selection (GO:0045060)2.68820527
82peptidyl-threonine modification (GO:0018210)2.68295016
83sister chromatid cohesion (GO:0007062)2.68078495
84mitotic sister chromatid segregation (GO:0000070)2.68058257
85iron ion import (GO:0097286)2.67136346
86positive regulation of protein import into nucleus, translocation (GO:0033160)2.63738125
87negative regulation of fibroblast apoptotic process (GO:2000270)2.62830598
88positive regulation of DNA-templated transcription, initiation (GO:2000144)2.61732676
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61501305
90DNA strand elongation involved in DNA replication (GO:0006271)2.58846433
91DNA strand elongation (GO:0022616)2.56326685
92nucleus localization (GO:0051647)2.54331060
93DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.54299901
94rRNA catabolic process (GO:0016075)2.54272285
95nuclear envelope disassembly (GO:0051081)2.53427669
96membrane disassembly (GO:0030397)2.53427669
97peptidyl-threonine dephosphorylation (GO:0035970)2.52974987
98protein K63-linked deubiquitination (GO:0070536)2.52624744
99mitotic chromosome condensation (GO:0007076)2.52328373
100spindle assembly (GO:0051225)2.51178721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.34834736
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.65618482
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.64766906
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.12668602
5GATA1_22025678_ChIP-Seq_K562_Human3.42063159
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.24114534
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82430209
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69813199
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.38600812
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27138252
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22017526
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.20458210
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.10855032
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.00492967
15AR_21572438_ChIP-Seq_LNCaP_Human1.88898523
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76878523
17TP53_16413492_ChIP-PET_HCT116_Human1.76534883
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75693028
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74294253
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.60091257
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52742532
22IGF1R_20145208_ChIP-Seq_DFB_Human1.52273446
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.47324946
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47233303
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44734693
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.43969720
27EWS_26573619_Chip-Seq_HEK293_Human1.42092727
28MYC_22102868_ChIP-Seq_BL_Human1.41943637
29TAF15_26573619_Chip-Seq_HEK293_Human1.41780459
30ER_23166858_ChIP-Seq_MCF-7_Human1.40900878
31SCL_19346495_ChIP-Seq_HPC-7_Human1.40704480
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39305953
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.39217625
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33308970
35MYB_26560356_Chip-Seq_TH1_Human1.31500523
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31264280
37RUNX_20019798_ChIP-Seq_JUKART_Human1.30975876
38MYB_26560356_Chip-Seq_TH2_Human1.27339909
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.26407195
40NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23399301
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22523081
42FUS_26573619_Chip-Seq_HEK293_Human1.20666745
43SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18387423
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16480743
45TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15686780
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.14392774
47STAT3_23295773_ChIP-Seq_U87_Human1.13838355
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13699522
49DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13419044
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13331742
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12747073
52PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11310753
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11080543
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10903327
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.09887917
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08703070
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07392493
58PU_27001747_Chip-Seq_BMDM_Mouse1.03336918
59VDR_21846776_ChIP-Seq_THP-1_Human1.02579308
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02040177
61AR_21909140_ChIP-Seq_LNCAP_Human1.01370774
62CHD1_26751641_Chip-Seq_LNCaP_Human1.01365814
63VDR_24787735_ChIP-Seq_THP-1_Human1.01260447
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00535507
65CIITA_25753668_ChIP-Seq_RAJI_Human0.98821430
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98618542
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98208791
68SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97585630
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95821437
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95048259
71NFE2_27457419_Chip-Seq_LIVER_Mouse0.94367254
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94302907
73IRF1_19129219_ChIP-ChIP_H3396_Human0.93067696
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92911162
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92911162
76PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92910381
77SALL4_22934838_ChIP-ChIP_CD34+_Human0.91518233
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90900073
79SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90701354
80OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89494373
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89141584
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87813156
83E2F1_18555785_Chip-Seq_ESCs_Mouse0.87715791
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87191665
85ARNT_22903824_ChIP-Seq_MCF-7_Human0.86293962
86PRDM14_20953172_ChIP-Seq_ESCs_Human0.86007321
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85478194
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84253802
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82921776
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81768746
91TCF7_22412390_ChIP-Seq_EML_Mouse0.81698416
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80826097
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.80775966
94FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80488128
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78842136
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78605543
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.78177921
98MAF_26560356_Chip-Seq_TH1_Human0.76465448
99ESR1_20079471_ChIP-ChIP_T-47D_Human0.76030043
100SOX9_26525672_Chip-Seq_HEART_Mouse0.75886834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation8.47567252
2MP0008057_abnormal_DNA_replication8.06661671
3MP0002009_preneoplasia2.68616826
4MP0005075_abnormal_melanosome_morpholog2.35454813
5MP0010352_gastrointestinal_tract_polyps2.15284955
6MP0002396_abnormal_hematopoietic_system2.06299918
7MP0003763_abnormal_thymus_physiology2.01430950
8MP0010094_abnormal_chromosome_stability2.01280577
9MP0005076_abnormal_cell_differentiation1.97865219
10MP0005174_abnormal_tail_pigmentation1.97368384
11MP0010307_abnormal_tumor_latency1.89673595
12MP0004381_abnormal_hair_follicle1.89512604
13MP0003111_abnormal_nucleus_morphology1.83434554
14MP0000383_abnormal_hair_follicle1.81298050
15MP0003077_abnormal_cell_cycle1.78114270
16MP0000371_diluted_coat_color1.77600674
17MP0003656_abnormal_erythrocyte_physiolo1.76759876
18MP0000427_abnormal_hair_cycle1.73394377
19MP0003890_abnormal_embryonic-extraembry1.68410362
20MP0003828_pulmonary_edema1.66225520
21MP0004808_abnormal_hematopoietic_stem1.60417372
22MP0004957_abnormal_blastocyst_morpholog1.60373225
23MP0003091_abnormal_cell_migration1.59197718
24MP0000015_abnormal_ear_pigmentation1.54933656
25MP0000647_abnormal_sebaceous_gland1.50531626
26MP0000685_abnormal_immune_system1.47006534
27MP0002166_altered_tumor_susceptibility1.46890900
28MP0005310_abnormal_salivary_gland1.46155885
29MP0008995_early_reproductive_senescence1.43675128
30MP0002006_tumorigenesis1.43156701
31MP0005083_abnormal_biliary_tract1.38425677
32MP0010678_abnormal_skin_adnexa1.30014146
33MP0001835_abnormal_antigen_presentation1.27557329
34MP0003646_muscle_fatigue1.27335679
35MP0003786_premature_aging1.27233193
36MP0003705_abnormal_hypodermis_morpholog1.25544614
37MP0002075_abnormal_coat/hair_pigmentati1.23784190
38MP0000703_abnormal_thymus_morphology1.21689642
39MP0003172_abnormal_lysosome_physiology1.15021400
40MP0003300_gastrointestinal_ulcer1.14748277
41MP0002095_abnormal_skin_pigmentation1.10214140
42MP0002938_white_spotting1.09557853
43MP0004130_abnormal_muscle_cell1.07056759
44MP0005187_abnormal_penis_morphology1.05673737
45MP0005266_abnormal_metabolism1.04718569
46MP0001186_pigmentation_phenotype1.04067796
47MP0001800_abnormal_humoral_immune1.03825687
48MP0002928_abnormal_bile_duct0.99000131
49MP0002405_respiratory_system_inflammati0.98681561
50MP0006035_abnormal_mitochondrial_morpho0.98295656
51MP0002019_abnormal_tumor_incidence0.97300150
52MP0002092_abnormal_eye_morphology0.97120507
53MP0003984_embryonic_growth_retardation0.96799099
54MP0002398_abnormal_bone_marrow0.96426166
55MP0000350_abnormal_cell_proliferation0.95350382
56MP0002088_abnormal_embryonic_growth/wei0.95280982
57MP0003632_abnormal_nervous_system0.95180477
58MP0010030_abnormal_orbit_morphology0.93758607
59MP0000428_abnormal_craniofacial_morphol0.92281304
60MP0006054_spinal_hemorrhage0.92094785
61MP0002697_abnormal_eye_size0.91296524
62MP0002970_abnormal_white_adipose0.90468246
63MP0003221_abnormal_cardiomyocyte_apopto0.88644634
64MP0000689_abnormal_spleen_morphology0.88542611
65MP0005408_hypopigmentation0.86836413
66MP0002722_abnormal_immune_system0.86681580
67MP0002086_abnormal_extraembryonic_tissu0.83915994
68MP0000377_abnormal_hair_follicle0.83041561
69MP0004185_abnormal_adipocyte_glucose0.82550846
70MP0000716_abnormal_immune_system0.82287416
71MP0005220_abnormal_exocrine_pancreas0.82059057
72MP0005621_abnormal_cell_physiology0.81682798
73MP0001697_abnormal_embryo_size0.80609147
74MP0005171_absent_coat_pigmentation0.80431931
75MP0001324_abnormal_eye_pigmentation0.80073134
76MP0001672_abnormal_embryogenesis/_devel0.79296534
77MP0005380_embryogenesis_phenotype0.79296534
78MP0000733_abnormal_muscle_development0.78644766
79MP0001286_abnormal_eye_development0.78046089
80MP0004197_abnormal_fetal_growth/weight/0.77591426
81MP0002332_abnormal_exercise_endurance0.77393430
82MP0009115_abnormal_fat_cell0.77295334
83MP0001346_abnormal_lacrimal_gland0.76998658
84MP0002084_abnormal_developmental_patter0.75938568
85MP0002751_abnormal_autonomic_nervous0.74101462
86MP0005387_immune_system_phenotype0.74013928
87MP0001790_abnormal_immune_system0.74013928
88MP0002089_abnormal_postnatal_growth/wei0.70610485
89MP0002429_abnormal_blood_cell0.70422088
90MP0001293_anophthalmia0.70003272
91MP0000604_amyloidosis0.68829026
92MP0002109_abnormal_limb_morphology0.66121129
93MP0003690_abnormal_glial_cell0.66101705
94MP0002452_abnormal_antigen_presenting0.65553652
95MP0001915_intracranial_hemorrhage0.65378434
96MP0000613_abnormal_salivary_gland0.64878246
97MP0003693_abnormal_embryo_hatching0.63811827
98MP0005451_abnormal_body_composition0.63168659
99MP0004142_abnormal_muscle_tone0.62929405
100MP0004043_abnormal_pH_regulation0.61916199

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.92610134
2Abnormality of the fingertips (HP:0001211)3.90880811
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46603927
4Abnormality of the pons (HP:0007361)3.23724925
5Abnormality of chromosome stability (HP:0003220)3.20741058
6IgA deficiency (HP:0002720)3.15593370
7Chromsome breakage (HP:0040012)3.13092337
8Hypoplasia of the pons (HP:0012110)3.06279318
9Syringomyelia (HP:0003396)3.00134540
10Spinal cord lesions (HP:0100561)3.00134540
11Birth length less than 3rd percentile (HP:0003561)2.98757358
12Prominent nose (HP:0000448)2.97048454
13T lymphocytopenia (HP:0005403)2.94106587
14IgM deficiency (HP:0002850)2.88400967
15Conjunctival telangiectasia (HP:0000524)2.80312046
16Colitis (HP:0002583)2.68673542
17Broad face (HP:0000283)2.67567085
18Heterotopia (HP:0002282)2.64207672
19Anal stenosis (HP:0002025)2.63029322
20Chronic hepatic failure (HP:0100626)2.62327874
21Short 4th metacarpal (HP:0010044)2.56867234
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.56867234
23Dysmetric saccades (HP:0000641)2.56671228
24Hyperkalemia (HP:0002153)2.53343019
25Narrow palate (HP:0000189)2.52709335
26Subacute progressive viral hepatitis (HP:0006572)2.51899120
27Deep philtrum (HP:0002002)2.50320671
28Genetic anticipation (HP:0003743)2.49000354
29Abnormality of the distal phalanx of the thumb (HP:0009617)2.38746056
30Neurodegeneration (HP:0002180)2.38726581
31Recurrent cutaneous fungal infections (HP:0011370)2.38698259
32Chronic mucocutaneous candidiasis (HP:0002728)2.38698259
33Viral hepatitis (HP:0006562)2.37706419
34Abnormality of the vasculature of the conjunctiva (HP:0008054)2.37644005
35Abnormality of T cell number (HP:0011839)2.33775523
36Sandal gap (HP:0001852)2.33585426
37Long eyelashes (HP:0000527)2.31110165
38Abnormality of DNA repair (HP:0003254)2.30936010
39Acute myeloid leukemia (HP:0004808)2.29129283
40Overgrowth (HP:0001548)2.28507442
41Macroorchidism (HP:0000053)2.26908603
42Vertebral arch anomaly (HP:0008438)2.23299721
43Recurrent fungal infections (HP:0002841)2.20637012
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.19809843
45Absent/shortened dynein arms (HP:0200106)2.19809843
46Microtia (HP:0008551)2.19087213
47Recurrent viral infections (HP:0004429)2.16773335
48Hypoplasia of the thymus (HP:0000778)2.16639955
49Obsessive-compulsive behavior (HP:0000722)2.15240318
50Gingivitis (HP:0000230)2.11660327
51Acute lymphatic leukemia (HP:0006721)2.11169978
52Breast hypoplasia (HP:0003187)2.10383131
53Recurrent bronchitis (HP:0002837)2.08680800
54Thyroiditis (HP:0100646)2.08177747
55Fair hair (HP:0002286)2.05577621
56Neoplasm of the adrenal cortex (HP:0100641)2.04564058
57Truncal obesity (HP:0001956)2.03247606
58Protruding tongue (HP:0010808)2.02338802
59Aqueductal stenosis (HP:0002410)1.99775095
60Thoracolumbar scoliosis (HP:0002944)1.97749087
61Periodontitis (HP:0000704)1.96798718
62Premature graying of hair (HP:0002216)1.95801507
63Microvesicular hepatic steatosis (HP:0001414)1.95198822
64Diastasis recti (HP:0001540)1.94993433
65Menstrual irregularities (HP:0000858)1.93742876
66Tubulointerstitial nephritis (HP:0001970)1.93530232
67Ectopic kidney (HP:0000086)1.91527315
68Absent radius (HP:0003974)1.90447420
69Abnormality of the sella turcica (HP:0002679)1.88414865
70Abnormality of the nasal septum (HP:0000419)1.88107847
71Abnormality of the labia majora (HP:0012881)1.88073495
72Hematochezia (HP:0002573)1.87141086
73Sparse lateral eyebrow (HP:0005338)1.85641949
74Hepatitis (HP:0012115)1.82699236
75Duplicated collecting system (HP:0000081)1.81828932
76Tracheomalacia (HP:0002779)1.81650109
77Recurrent bacterial skin infections (HP:0005406)1.81583930
78Oligodactyly (hands) (HP:0001180)1.80867952
79Short nail (HP:0001799)1.79388157
80Clubbing of toes (HP:0100760)1.79015423
81Plagiocephaly (HP:0001357)1.77692303
82Cafe-au-lait spot (HP:0000957)1.76664569
83Deformed sella turcica (HP:0002681)1.75665989
84Submucous cleft hard palate (HP:0000176)1.73974787
85Anhidrosis (HP:0000970)1.73567399
86Absent forearm bone (HP:0003953)1.72335161
87Aplasia involving forearm bones (HP:0009822)1.72335161
88Slow saccadic eye movements (HP:0000514)1.71971646
89Hypoplastic labia majora (HP:0000059)1.69536921
90Osteolytic defects of the phalanges of the hand (HP:0009771)1.68723333
91Osteolytic defects of the hand bones (HP:0009699)1.68723333
92Low anterior hairline (HP:0000294)1.68506520
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67852079
94Dislocated radial head (HP:0003083)1.67539822
95Cellular immunodeficiency (HP:0005374)1.67333010
96Acute hepatic failure (HP:0006554)1.67201720
97Hamartoma (HP:0010566)1.66012912
98Calcaneovalgus deformity (HP:0001848)1.64153404
99Thick eyebrow (HP:0000574)1.63786066
100Generalized hypopigmentation of hair (HP:0011358)1.63782931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.73602594
2FRK3.72437226
3CDC73.28893721
4BRD43.12044057
5NEK92.92002713
6BLK2.61960732
7ZAK2.57482830
8MKNK22.18297138
9ACVR1B2.12850911
10AKT32.10388475
11CAMK1D2.00089104
12MELK1.92449974
13MAP3K101.91327725
14SGK21.79555439
15EEF2K1.79018516
16WNK11.78746646
17BRSK21.70542144
18STK241.62106520
19CAMK1G1.61290839
20TLK11.59987262
21ICK1.54822715
22MKNK11.51921155
23NLK1.34572758
24MAP3K21.31329247
25PIM11.26782035
26FGFR21.24804689
27TAF11.24589335
28DYRK31.22040265
29SGK31.21992737
30MAP2K31.20362086
31FGFR31.18098833
32STK41.17371925
33CAMKK21.15079545
34SGK2231.12540192
35SGK4941.12540192
36MAP3K71.11789629
37ATR1.08875483
38MARK20.97983090
39CDK60.97082822
40BMPR1B0.92291369
41ERBB20.92240597
42TYK20.92150419
43TRPM70.90097219
44RPS6KB20.88881142
45PIK3CG0.87510073
46NEK60.87241540
47CHEK20.87008108
48MAPK110.86032463
49MTOR0.85754612
50STK110.85488345
51LATS10.83327666
52CDK80.82478836
53STK38L0.82276916
54RPS6KA50.80211110
55SGK10.79478776
56SMG10.78709535
57CDK40.78162284
58CAMK40.77775010
59PRKAA20.76035372
60TSSK60.74883887
61HIPK20.74065559
62NUAK10.73490290
63SRPK10.73010174
64TEC0.66791869
65PDGFRB0.65616742
66JAK10.65340943
67BTK0.62812554
68ALK0.62148695
69TRIB30.61510829
70RAF10.60095457
71CSK0.59821062
72MAP3K80.58945435
73TTN0.58818598
74PLK30.58379322
75ATM0.57664656
76AKT10.57332681
77MAP3K60.56645480
78CHEK10.54668181
79IKBKE0.53776196
80PLK20.52486045
81VRK10.49633664
82IRAK10.48187521
83DYRK1A0.48055566
84PKN20.46792387
85MAP3K10.45311263
86AURKB0.44983165
87MARK30.43023404
88PRKAA10.42751937
89CHUK0.42566446
90KSR10.42551685
91RPS6KB10.42104174
92PTK2B0.41966936
93CAMKK10.41246879
94SYK0.39683341
95SCYL20.39339221
96RET0.38489743
97MAP2K40.36002709
98MAPK100.32818331
99HCK0.32012190
100MST1R0.31763044

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.19260210
2Alcoholism_Homo sapiens_hsa050342.44613646
3Cell cycle_Homo sapiens_hsa041102.03399634
4DNA replication_Homo sapiens_hsa030302.00637363
5Lysine degradation_Homo sapiens_hsa003101.99728353
6Viral carcinogenesis_Homo sapiens_hsa052031.96843672
7Non-homologous end-joining_Homo sapiens_hsa034501.91211017
8Non-small cell lung cancer_Homo sapiens_hsa052231.86406716
9p53 signaling pathway_Homo sapiens_hsa041151.78520588
10MicroRNAs in cancer_Homo sapiens_hsa052061.70758694
11Chronic myeloid leukemia_Homo sapiens_hsa052201.70623856
12mTOR signaling pathway_Homo sapiens_hsa041501.63186959
13Fanconi anemia pathway_Homo sapiens_hsa034601.60206887
14Dorso-ventral axis formation_Homo sapiens_hsa043201.58996329
15Small cell lung cancer_Homo sapiens_hsa052221.57424657
16Colorectal cancer_Homo sapiens_hsa052101.53786519
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.46930390
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46927000
19Longevity regulating pathway - mammal_Homo sapiens_hsa042111.44158290
20Pancreatic cancer_Homo sapiens_hsa052121.38311157
21FoxO signaling pathway_Homo sapiens_hsa040681.37909280
22Prostate cancer_Homo sapiens_hsa052151.34910975
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.34488296
24Basal cell carcinoma_Homo sapiens_hsa052171.32018121
25Hepatitis B_Homo sapiens_hsa051611.31735215
26HTLV-I infection_Homo sapiens_hsa051661.27341184
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24034115
28Acute myeloid leukemia_Homo sapiens_hsa052211.23406132
29Nucleotide excision repair_Homo sapiens_hsa034201.22001122
30B cell receptor signaling pathway_Homo sapiens_hsa046621.20808178
31Homologous recombination_Homo sapiens_hsa034401.19534249
32Endometrial cancer_Homo sapiens_hsa052131.19252555
33Measles_Homo sapiens_hsa051621.18915546
34Hedgehog signaling pathway_Homo sapiens_hsa043401.18460769
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17460026
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.16474472
37Inositol phosphate metabolism_Homo sapiens_hsa005621.15948106
38T cell receptor signaling pathway_Homo sapiens_hsa046601.15461588
39TGF-beta signaling pathway_Homo sapiens_hsa043501.14121135
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13666297
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13182865
42Mismatch repair_Homo sapiens_hsa034301.11963524
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11498230
44Glioma_Homo sapiens_hsa052141.09785063
45TNF signaling pathway_Homo sapiens_hsa046681.07321757
46Notch signaling pathway_Homo sapiens_hsa043301.05807257
47Osteoclast differentiation_Homo sapiens_hsa043801.05664387
48Other glycan degradation_Homo sapiens_hsa005111.03832623
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01991585
50Prolactin signaling pathway_Homo sapiens_hsa049171.01632798
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99485062
52ErbB signaling pathway_Homo sapiens_hsa040120.99474472
53Primary immunodeficiency_Homo sapiens_hsa053400.98181784
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96979644
55Taste transduction_Homo sapiens_hsa047420.96286789
56Thyroid cancer_Homo sapiens_hsa052160.95617976
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91014580
58Renal cell carcinoma_Homo sapiens_hsa052110.90567579
59Type II diabetes mellitus_Homo sapiens_hsa049300.88171400
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.87722566
61Fatty acid biosynthesis_Homo sapiens_hsa000610.86358526
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84652399
63Influenza A_Homo sapiens_hsa051640.84412114
64Wnt signaling pathway_Homo sapiens_hsa043100.83360418
65Herpes simplex infection_Homo sapiens_hsa051680.83269959
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82544617
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80951124
68Toxoplasmosis_Homo sapiens_hsa051450.80501485
69Adherens junction_Homo sapiens_hsa045200.77526552
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76842580
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76130132
72One carbon pool by folate_Homo sapiens_hsa006700.75568126
73RNA transport_Homo sapiens_hsa030130.74849698
74Tuberculosis_Homo sapiens_hsa051520.74055157
75Proteoglycans in cancer_Homo sapiens_hsa052050.72057144
76Hippo signaling pathway_Homo sapiens_hsa043900.71853757
77Epstein-Barr virus infection_Homo sapiens_hsa051690.71571850
78Apoptosis_Homo sapiens_hsa042100.71208184
79Hepatitis C_Homo sapiens_hsa051600.70949811
80Insulin resistance_Homo sapiens_hsa049310.69530582
81Pathways in cancer_Homo sapiens_hsa052000.69481799
82RNA degradation_Homo sapiens_hsa030180.66943641
83Leishmaniasis_Homo sapiens_hsa051400.62843878
84Oocyte meiosis_Homo sapiens_hsa041140.62527513
85Cholinergic synapse_Homo sapiens_hsa047250.62463309
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.62005230
87Long-term potentiation_Homo sapiens_hsa047200.61448419
88mRNA surveillance pathway_Homo sapiens_hsa030150.60762680
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59006256
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59001286
91Melanogenesis_Homo sapiens_hsa049160.58550078
92Bladder cancer_Homo sapiens_hsa052190.58457452
93Platelet activation_Homo sapiens_hsa046110.56208835
94Spliceosome_Homo sapiens_hsa030400.55619835
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55267155
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.54573732
97Chemokine signaling pathway_Homo sapiens_hsa040620.53527737
98Hematopoietic cell lineage_Homo sapiens_hsa046400.53475916
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53270650
100MAPK signaling pathway_Homo sapiens_hsa040100.52856412

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