RYR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.78081862
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.76580914
3locomotory exploration behavior (GO:0035641)5.35579130
4ionotropic glutamate receptor signaling pathway (GO:0035235)5.32727074
5vocalization behavior (GO:0071625)5.32315341
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.03349807
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.00250296
8protein localization to synapse (GO:0035418)4.87888806
9regulation of long-term neuronal synaptic plasticity (GO:0048169)4.81774033
10glutamate receptor signaling pathway (GO:0007215)4.77504741
11regulation of glutamate receptor signaling pathway (GO:1900449)4.77367883
12synaptic vesicle maturation (GO:0016188)4.76914512
13regulation of synapse structural plasticity (GO:0051823)4.65866435
14synaptic vesicle exocytosis (GO:0016079)4.62105732
15synaptic transmission, glutamatergic (GO:0035249)4.57476828
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.53351267
17regulation of neuronal synaptic plasticity (GO:0048168)4.51883666
18neuron-neuron synaptic transmission (GO:0007270)4.44352937
19neuronal action potential propagation (GO:0019227)4.36556945
20exploration behavior (GO:0035640)4.36003633
21cilium or flagellum-dependent cell motility (GO:0001539)4.35689245
22regulation of skeletal muscle contraction (GO:0014819)4.28144902
23neuron cell-cell adhesion (GO:0007158)4.27695736
24neurotransmitter-gated ion channel clustering (GO:0072578)4.24474556
25regulation of synaptic vesicle exocytosis (GO:2000300)4.18152825
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17678440
27prepulse inhibition (GO:0060134)4.11622130
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.11511762
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.11446924
30dendritic spine morphogenesis (GO:0060997)4.09154003
31long-term memory (GO:0007616)4.08737122
32synaptic vesicle docking involved in exocytosis (GO:0016081)4.06848286
33regulation of dendritic spine morphogenesis (GO:0061001)4.02639639
34striatum development (GO:0021756)3.98965641
35axonemal dynein complex assembly (GO:0070286)3.94393857
36synaptic transmission, dopaminergic (GO:0001963)3.93421242
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.93297493
38regulation of postsynaptic membrane potential (GO:0060078)3.92169142
39transmission of nerve impulse (GO:0019226)3.91078654
40neurotransmitter secretion (GO:0007269)3.86247109
41cilium movement (GO:0003341)3.83955495
42positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.81887382
43positive regulation of membrane potential (GO:0045838)3.81871057
44regulation of synaptic vesicle transport (GO:1902803)3.81220848
45glutamate secretion (GO:0014047)3.80374500
46positive regulation of synapse maturation (GO:0090129)3.78720183
47negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.78627427
48behavioral defense response (GO:0002209)3.76983975
49behavioral fear response (GO:0001662)3.76983975
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.76766685
51neuron recognition (GO:0008038)3.76673227
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.76453047
53cellular potassium ion homeostasis (GO:0030007)3.73824312
54sarcoplasmic reticulum calcium ion transport (GO:0070296)3.70650412
55positive regulation of synaptic transmission, GABAergic (GO:0032230)3.69815155
56regulation of synaptic plasticity (GO:0048167)3.68788220
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.68434338
58auditory behavior (GO:0031223)3.66654161
59axonal fasciculation (GO:0007413)3.66126196
60neuronal ion channel clustering (GO:0045161)3.63663896
61long-term synaptic potentiation (GO:0060291)3.60831234
62epithelial cilium movement (GO:0003351)3.58659532
63layer formation in cerebral cortex (GO:0021819)3.57947258
64positive regulation of neurotransmitter transport (GO:0051590)3.55872485
65neuromuscular process controlling balance (GO:0050885)3.52824423
66positive regulation of neurotransmitter secretion (GO:0001956)3.51832891
67regulation of relaxation of muscle (GO:1901077)3.51814250
68response to histamine (GO:0034776)3.51184808
69behavioral response to nicotine (GO:0035095)3.49973742
70behavioral response to cocaine (GO:0048148)3.49401520
71response to auditory stimulus (GO:0010996)3.48491923
72gamma-aminobutyric acid transport (GO:0015812)3.48069667
73membrane depolarization during action potential (GO:0086010)3.47376584
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.47354508
75actin-myosin filament sliding (GO:0033275)3.46740613
76muscle filament sliding (GO:0030049)3.46740613
77regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.46522483
78membrane hyperpolarization (GO:0060081)3.44013994
79neuronal action potential (GO:0019228)3.42825393
80fear response (GO:0042596)3.40601319
81presynaptic membrane assembly (GO:0097105)3.39667823
82axoneme assembly (GO:0035082)3.38294332
83response to amphetamine (GO:0001975)3.37995295
84positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.37990132
85membrane depolarization (GO:0051899)3.37010595
86positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.36254104
87positive regulation of dendritic spine morphogenesis (GO:0061003)3.36225985
88innervation (GO:0060384)3.34204373
89learning (GO:0007612)3.32499739
90adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.31841265
91neuromuscular synaptic transmission (GO:0007274)3.28871702
92regulation of glutamate secretion (GO:0014048)3.28644479
93regulation of dendritic spine development (GO:0060998)3.27532637
94synaptic vesicle endocytosis (GO:0048488)3.25769225
95positive regulation of dendritic spine development (GO:0060999)3.23952315
96regulation of female receptivity (GO:0045924)3.23747300
97dopamine receptor signaling pathway (GO:0007212)3.23317766
98dendritic spine organization (GO:0097061)3.21845420
99regulation of vesicle fusion (GO:0031338)3.20841586
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20068518
101neurotransmitter transport (GO:0006836)3.19418968
102regulation of cell communication by electrical coupling (GO:0010649)3.18023251
103sodium ion export (GO:0071436)3.18012334
104protein polyglutamylation (GO:0018095)3.17114229
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.12851351
106presynaptic membrane organization (GO:0097090)3.11548218
107skeletal muscle contraction (GO:0003009)3.10235263
108visual learning (GO:0008542)3.07291283
109long term synaptic depression (GO:0060292)3.07059135
110cell communication by electrical coupling (GO:0010644)3.05122620
111postsynaptic membrane organization (GO:0001941)3.04039706
112activation of protein kinase A activity (GO:0034199)3.03321097
113regulation of neurotransmitter secretion (GO:0046928)3.03149416
114positive regulation of synaptic transmission (GO:0050806)3.02942495
115proline transport (GO:0015824)3.02495316
116cAMP catabolic process (GO:0006198)3.01771705
117neuromuscular process controlling posture (GO:0050884)3.01542040
118synapse assembly (GO:0007416)3.01320605
119cerebellar Purkinje cell differentiation (GO:0021702)3.00510250
120mating behavior (GO:0007617)2.99263086
121response to pheromone (GO:0019236)2.98794331
122regulation of neurotransmitter levels (GO:0001505)2.97885442
123neuromuscular process (GO:0050905)2.96870946
124axon ensheathment in central nervous system (GO:0032291)2.91334984
125central nervous system myelination (GO:0022010)2.91334984
126* negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90476777
127motile cilium assembly (GO:0044458)2.89487753
128action potential (GO:0001508)2.84402094
129serotonin metabolic process (GO:0042428)2.83642651
130primary amino compound metabolic process (GO:1901160)2.82778662
131actin-mediated cell contraction (GO:0070252)2.81446757
132C4-dicarboxylate transport (GO:0015740)2.80825214
133positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75286030
134regulation of membrane repolarization (GO:0060306)2.75043793
135negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74974089
136regulation of neurotransmitter uptake (GO:0051580)2.73855674
137detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.72250970
138startle response (GO:0001964)2.66485735
139retinal cone cell development (GO:0046549)2.65870608
140regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65737612
141positive regulation of potassium ion transmembrane transport (GO:1901381)2.65423160
142detection of light stimulus involved in visual perception (GO:0050908)2.65412460
143detection of light stimulus involved in sensory perception (GO:0050962)2.65412460
144reflex (GO:0060004)2.64159542
145cornea development in camera-type eye (GO:0061303)2.61521679
146interkinetic nuclear migration (GO:0022027)2.59471178
147regulation of cilium movement (GO:0003352)2.56646941
148one-carbon compound transport (GO:0019755)2.56228198
149regulation of sarcomere organization (GO:0060297)2.55301302
150positive regulation of sodium ion transmembrane transport (GO:1902307)2.54197895
151myotube cell development (GO:0014904)2.53856215
152left/right axis specification (GO:0070986)2.53846547
153myofibril assembly (GO:0030239)2.52906247
154regulation of action potential (GO:0098900)2.52755766
155regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.52566864
156* striated muscle contraction (GO:0006941)2.49169651
157cilium organization (GO:0044782)2.49087503
158response to inactivity (GO:0014854)2.48712590
159regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.47385476
160regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.45747084
161somite development (GO:0061053)2.44089549
162neural tube formation (GO:0001841)2.42548299
163cilium assembly (GO:0042384)2.42225690
164otic vesicle formation (GO:0030916)2.40867216
165positive regulation of meiosis (GO:0045836)2.40562300
166regulation of sodium ion transmembrane transporter activity (GO:2000649)2.40524299
167skeletal muscle fiber development (GO:0048741)2.39999941
168behavioral response to ethanol (GO:0048149)2.39873921
169calcium ion import (GO:0070509)2.39801852
170microtubule bundle formation (GO:0001578)2.39481956
171positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.38405362
172regulation of synapse maturation (GO:0090128)2.37698553
173potassium ion transmembrane transport (GO:0071805)2.36826118
174cellular potassium ion transport (GO:0071804)2.36826118
175regulation of sodium ion transmembrane transport (GO:1902305)2.36668826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.71723982
2* GBX2_23144817_ChIP-Seq_PC3_Human3.89495051
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11315432
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09109101
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09003125
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.79055425
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68696026
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68696026
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66840552
10DROSHA_22980978_ChIP-Seq_HELA_Human2.66127478
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65227689
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.60189328
13VDR_22108803_ChIP-Seq_LS180_Human2.57651258
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.53175595
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49204507
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45923121
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44981280
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41786074
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.31076420
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30209366
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.22268212
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.20262266
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19703152
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11797199
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.05565025
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01583331
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00476583
28AR_21572438_ChIP-Seq_LNCaP_Human1.87611888
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87510278
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85513591
31* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81791130
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78438068
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77924207
34TAF15_26573619_Chip-Seq_HEK293_Human1.75496757
35SMAD4_21799915_ChIP-Seq_A2780_Human1.72426113
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68058155
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62736336
38ER_23166858_ChIP-Seq_MCF-7_Human1.61542850
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60133375
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.54625985
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53476718
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52449955
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51110984
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.48541109
45* P300_19829295_ChIP-Seq_ESCs_Human1.44834657
46* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43090504
47CBP_20019798_ChIP-Seq_JUKART_Human1.41820799
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41820799
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.40347033
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37492474
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36452553
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34614534
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.33929832
54ZNF274_21170338_ChIP-Seq_K562_Hela1.33128191
55* STAT3_23295773_ChIP-Seq_U87_Human1.32751571
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30869909
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.29394443
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28998732
59AR_25329375_ChIP-Seq_VCAP_Human1.27769839
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27336750
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27151618
62EWS_26573619_Chip-Seq_HEK293_Human1.26603189
63* AR_19668381_ChIP-Seq_PC3_Human1.24717451
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23399345
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.21854111
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21810554
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20117846
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19479538
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.18982603
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18976965
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18958393
72IGF1R_20145208_ChIP-Seq_DFB_Human1.18631091
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.18591408
74TP53_16413492_ChIP-PET_HCT116_Human1.17894689
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.17273200
76* TCF4_23295773_ChIP-Seq_U87_Human1.16004523
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15821274
78* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15765595
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15459437
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15283318
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13724612
82NANOG_19829295_ChIP-Seq_ESCs_Human1.11910636
83SOX2_19829295_ChIP-Seq_ESCs_Human1.11910636
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11047786
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10960987
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.10657094
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.10523270
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09877496
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09770224
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09765775
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09498502
92TCF4_22108803_ChIP-Seq_LS180_Human1.09427641
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.09238199
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08968746
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08551330
96AHR_22903824_ChIP-Seq_MCF-7_Human1.08254603
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.08107084
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07957445
99* P53_22387025_ChIP-Seq_ESCs_Mouse1.07895833
100* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06902584
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06409365
102* SMAD3_21741376_ChIP-Seq_HESCs_Human1.05680330
103* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05314782
104FUS_26573619_Chip-Seq_HEK293_Human1.05118796
105* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04895840
106RUNX2_22187159_ChIP-Seq_PCA_Human1.03760486
107RNF2_27304074_Chip-Seq_NSC_Mouse1.03451494
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03319407
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02875514
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.02423226
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02213353
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02071261
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01965755
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01778524
115* E2F1_18555785_Chip-Seq_ESCs_Mouse1.01707914
116* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00865825
117* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99443986
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96680478
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95920197
120* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93973653
121* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92653883
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92155886
123* NANOG_18555785_Chip-Seq_ESCs_Mouse0.91711980
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91703973
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91703973
126* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89054608
127BCAT_22108803_ChIP-Seq_LS180_Human0.88509099
128* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88311526
129KDM2B_26808549_Chip-Seq_K562_Human0.87921461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.62686411
2MP0003880_abnormal_central_pattern5.28111670
3MP0002822_catalepsy4.92146522
4* MP0003635_abnormal_synaptic_transmissio4.16029608
5MP0003646_muscle_fatigue3.85712684
6MP0009745_abnormal_behavioral_response3.64074664
7MP0004270_analgesia3.52720287
8* MP0002063_abnormal_learning/memory/cond3.43801008
9MP0002064_seizures3.09789427
10MP0001968_abnormal_touch/_nociception2.82634306
11MP0009046_muscle_twitch2.81556168
12* MP0002572_abnormal_emotion/affect_behav2.79271419
13MP0001486_abnormal_startle_reflex2.66262885
14MP0002272_abnormal_nervous_system2.62613322
15MP0005423_abnormal_somatic_nervous2.55590594
16MP0001501_abnormal_sleep_pattern2.42398245
17MP0000749_muscle_degeneration2.41477659
18MP0002734_abnormal_mechanical_nocicepti2.30888431
19MP0002736_abnormal_nociception_after2.16827510
20MP0001529_abnormal_vocalization2.13341452
21MP0002735_abnormal_chemical_nociception2.01400092
22MP0001440_abnormal_grooming_behavior1.93497900
23MP0002638_abnormal_pupillary_reflex1.87965648
24MP0002067_abnormal_sensory_capabilities1.85961414
25MP0005646_abnormal_pituitary_gland1.85500072
26MP0002909_abnormal_adrenal_gland1.84044951
27MP0001188_hyperpigmentation1.81683417
28MP0004130_abnormal_muscle_cell1.78126354
29MP0001970_abnormal_pain_threshold1.75280213
30MP0004924_abnormal_behavior1.72280736
31MP0005386_behavior/neurological_phenoty1.72280736
32MP0002733_abnormal_thermal_nociception1.71446407
33MP0002184_abnormal_innervation1.70278764
34MP0002557_abnormal_social/conspecific_i1.69365092
35MP0000778_abnormal_nervous_system1.68391143
36MP0008569_lethality_at_weaning1.67779669
37MP0001984_abnormal_olfaction1.64307736
38MP0004036_abnormal_muscle_relaxation1.64253099
39MP0004811_abnormal_neuron_physiology1.56372732
40MP0004043_abnormal_pH_regulation1.55979439
41MP0003879_abnormal_hair_cell1.50862018
42MP0009780_abnormal_chondrocyte_physiolo1.50045405
43MP0003329_amyloid_beta_deposits1.45463374
44MP0000955_abnormal_spinal_cord1.44256867
45MP0003787_abnormal_imprinting1.43783274
46MP0005253_abnormal_eye_physiology1.39607283
47MP0005409_darkened_coat_color1.39054117
48MP0004885_abnormal_endolymph1.36162954
49MP0002882_abnormal_neuron_morphology1.34111152
50* MP0002066_abnormal_motor_capabilities/c1.33744345
51MP0008877_abnormal_DNA_methylation1.30121490
52MP0002106_abnormal_muscle_physiology1.29865662
53* MP0005620_abnormal_muscle_contractility1.29044992
54MP0004147_increased_porphyrin_level1.28557293
55MP0006276_abnormal_autonomic_nervous1.28387250
56MP0004858_abnormal_nervous_system1.26570281
57MP0001502_abnormal_circadian_rhythm1.24482418
58MP0003633_abnormal_nervous_system1.24219455
59MP0004133_heterotaxia1.22199335
60MP0003283_abnormal_digestive_organ1.21414602
61MP0004142_abnormal_muscle_tone1.20845345
62MP0005551_abnormal_eye_electrophysiolog1.20663304
63MP0004145_abnormal_muscle_electrophysio1.19362454
64MP0005369_muscle_phenotype1.18856859
65MP0002876_abnormal_thyroid_physiology1.17611825
66MP0004084_abnormal_cardiac_muscle1.16299090
67MP0002653_abnormal_ependyma_morphology1.15298568
68MP0000569_abnormal_digit_pigmentation1.15139158
69MP0001986_abnormal_taste_sensitivity1.12681821
70MP0001905_abnormal_dopamine_level1.09407132
71MP0005645_abnormal_hypothalamus_physiol1.08793357
72MP0002332_abnormal_exercise_endurance1.06934036
73MP0000751_myopathy1.04866460
74MP0002152_abnormal_brain_morphology1.02365165
75MP0008872_abnormal_physiological_respon1.00961906
76MP0003631_nervous_system_phenotype1.00117908
77MP0008874_decreased_physiological_sensi0.99422395
78MP0001177_atelectasis0.97664747
79MP0004085_abnormal_heartbeat0.97097334
80MP0008875_abnormal_xenobiotic_pharmacok0.94924783
81MP0002069_abnormal_eating/drinking_beha0.94290649
82MP0003122_maternal_imprinting0.93920100
83MP0002160_abnormal_reproductive_system0.93550927
84MP0004742_abnormal_vestibular_system0.92026542
85MP0003195_calcinosis0.91003586
86MP0002127_abnormal_cardiovascular_syste0.90918464
87MP0002229_neurodegeneration0.90902025
88MP0003137_abnormal_impulse_conducting0.90443422
89MP0000383_abnormal_hair_follicle0.90295688
90MP0000372_irregular_coat_pigmentation0.89320000
91MP0010386_abnormal_urinary_bladder0.89104183
92MP0003075_altered_response_to0.88885461
93MP0003136_yellow_coat_color0.88364015
94MP0000631_abnormal_neuroendocrine_gland0.87623583
95MP0002090_abnormal_vision0.85666316
96MP0002108_abnormal_muscle_morphology0.84991205
97MP0004215_abnormal_myocardial_fiber0.84930515
98MP0004087_abnormal_muscle_fiber0.84362296
99MP0000747_muscle_weakness0.83659365
100MP0002269_muscular_atrophy0.83191474
101MP0005499_abnormal_olfactory_system0.81864528
102MP0005394_taste/olfaction_phenotype0.81864528
103MP0002234_abnormal_pharynx_morphology0.80850772
104MP0006292_abnormal_olfactory_placode0.80709648
105MP0000759_abnormal_skeletal_muscle0.79055873
106MP0005535_abnormal_body_temperature0.77237468
107MP0004510_myositis0.76876223
108MP0008961_abnormal_basal_metabolism0.76227144
109MP0002837_dystrophic_cardiac_calcinosis0.75073483
110MP0002752_abnormal_somatic_nervous0.74598256
111MP0000230_abnormal_systemic_arterial0.74220908
112MP0008775_abnormal_heart_ventricle0.73701861
113MP0004233_abnormal_muscle_weight0.73516724
114MP0003634_abnormal_glial_cell0.73336106
115MP0001963_abnormal_hearing_physiology0.73331385
116MP0003011_delayed_dark_adaptation0.71583524
117MP0001485_abnormal_pinna_reflex0.69659977
118MP0000920_abnormal_myelination0.69291328
119MP0003690_abnormal_glial_cell0.66340910
120MP0005167_abnormal_blood-brain_barrier0.65565423
121MP0003045_fibrosis0.61330650
122MP0003632_abnormal_nervous_system0.61304567
123MP0004484_altered_response_of0.60312703
124MP0000013_abnormal_adipose_tissue0.59014958
125MP0001664_abnormal_digestion0.57781214
126MP0000604_amyloidosis0.54746134
127MP0002102_abnormal_ear_morphology0.53929243
128MP0001299_abnormal_eye_distance/0.53501491
129MP0006072_abnormal_retinal_apoptosis0.52942188
130MP0001943_abnormal_respiration0.52229290
131MP0000026_abnormal_inner_ear0.51807420
132MP0003861_abnormal_nervous_system0.49681006
133MP0010769_abnormal_survival0.48813248

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.31812055
2Myokymia (HP:0002411)7.48367683
3Focal seizures (HP:0007359)6.13254391
4Muscle fiber inclusion bodies (HP:0100299)5.00307803
5Nemaline bodies (HP:0003798)4.86700902
6Epileptic encephalopathy (HP:0200134)4.83381015
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.80911584
8Visual hallucinations (HP:0002367)4.68883673
9Febrile seizures (HP:0002373)4.68194272
10Absence seizures (HP:0002121)4.28897343
11Action tremor (HP:0002345)4.01624881
12Progressive cerebellar ataxia (HP:0002073)4.00968121
13Atonic seizures (HP:0010819)3.93887528
14Dialeptic seizures (HP:0011146)3.92771328
15Generalized tonic-clonic seizures (HP:0002069)3.91268575
16Broad-based gait (HP:0002136)3.80999745
17Muscle hypertrophy of the lower extremities (HP:0008968)3.80823471
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.79901474
19Distal arthrogryposis (HP:0005684)3.73177305
20Absent/shortened dynein arms (HP:0200106)3.65114398
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.65114398
22Poor eye contact (HP:0000817)3.59042306
23Calf muscle hypertrophy (HP:0008981)3.58545396
24Abnormal ciliary motility (HP:0012262)3.54684807
25Pancreatic fibrosis (HP:0100732)3.53626413
26True hermaphroditism (HP:0010459)3.50267791
27Abnormal respiratory motile cilium morphology (HP:0005938)3.47360511
28Abnormal respiratory epithelium morphology (HP:0012253)3.47360511
29Abnormal respiratory motile cilium physiology (HP:0012261)3.45088628
30Pancreatic cysts (HP:0001737)3.44958629
31Impaired vibration sensation in the lower limbs (HP:0002166)3.40410683
32Dysdiadochokinesis (HP:0002075)3.35571154
33Gaze-evoked nystagmus (HP:0000640)3.34088930
34Hyperventilation (HP:0002883)3.31951417
35Abnormal social behavior (HP:0012433)3.28732503
36Impaired social interactions (HP:0000735)3.28732503
37Type 1 muscle fiber predominance (HP:0003803)3.27960580
38Nephronophthisis (HP:0000090)3.27416513
39Dysmetria (HP:0001310)3.23091323
40Supranuclear gaze palsy (HP:0000605)3.22593517
41Anxiety (HP:0000739)3.21613926
42Depression (HP:0000716)3.19894333
43Exercise-induced myalgia (HP:0003738)3.18083741
44Molar tooth sign on MRI (HP:0002419)3.13272638
45Abnormality of midbrain morphology (HP:0002418)3.13272638
46Congenital stationary night blindness (HP:0007642)3.11224830
47Truncal ataxia (HP:0002078)3.08251001
48Rhinitis (HP:0012384)3.01667775
49Ankle clonus (HP:0011448)3.00302775
50Torticollis (HP:0000473)2.98439794
51Urinary bladder sphincter dysfunction (HP:0002839)2.98138467
52Scanning speech (HP:0002168)2.89504922
53Exercise-induced muscle cramps (HP:0003710)2.89421394
54Excessive salivation (HP:0003781)2.83679681
55Drooling (HP:0002307)2.83679681
56Amblyopia (HP:0000646)2.76437729
57Postural instability (HP:0002172)2.75507886
58Abnormality of the renal medulla (HP:0100957)2.74330627
59Abnormality of the calf musculature (HP:0001430)2.72600679
60Hemiparesis (HP:0001269)2.72062432
61Stereotypic behavior (HP:0000733)2.68940823
62Impaired smooth pursuit (HP:0007772)2.66350679
63Absent phalangeal crease (HP:0006109)2.62342113
64Annular pancreas (HP:0001734)2.62098840
65Cystic liver disease (HP:0006706)2.59791059
66Genetic anticipation (HP:0003743)2.59499229
67Cerebral inclusion bodies (HP:0100314)2.58904248
68Mutism (HP:0002300)2.58772451
69Focal dystonia (HP:0004373)2.57725812
70Neurofibrillary tangles (HP:0002185)2.55529607
71Abnormal eating behavior (HP:0100738)2.50518830
72Urinary urgency (HP:0000012)2.49525118
73Epileptiform EEG discharges (HP:0011182)2.47161547
74Muscle fiber splitting (HP:0003555)2.43556858
75Abnormal EKG (HP:0003115)2.42717337
76Fetal akinesia sequence (HP:0001989)2.42683420
77Abnormality of the lower motor neuron (HP:0002366)2.41400964
78Medial flaring of the eyebrow (HP:0010747)2.41384992
79Prolonged QT interval (HP:0001657)2.40729346
80Lower limb amyotrophy (HP:0007210)2.40332774
81Craniofacial dystonia (HP:0012179)2.39411465
82Hyperkalemia (HP:0002153)2.37078382
83Spastic gait (HP:0002064)2.36980727
84Intention tremor (HP:0002080)2.35131744
85Absent speech (HP:0001344)2.34827428
86Pointed chin (HP:0000307)2.33740061
87Round ear (HP:0100830)2.33363772
88Impaired vibratory sensation (HP:0002495)2.32179756
89Hemiplegia (HP:0002301)2.31570107
90Myotonia (HP:0002486)2.31300571
91Diplopia (HP:0000651)2.31031143
92Abnormality of binocular vision (HP:0011514)2.31031143
93Ankyloglossia (HP:0010296)2.29673088
94Progressive inability to walk (HP:0002505)2.29412765
95Abnormality of the renal cortex (HP:0011035)2.29340609
96Resting tremor (HP:0002322)2.29308716
97Abnormal finger flexion creases (HP:0006143)2.28286326
98Abnormality of ocular smooth pursuit (HP:0000617)2.27887957
99Bradykinesia (HP:0002067)2.26823275
100EEG with generalized epileptiform discharges (HP:0011198)2.26262946
101Dysmetric saccades (HP:0000641)2.25843244
102Status epilepticus (HP:0002133)2.25004777
103Tubular atrophy (HP:0000092)2.22230586
104Gait imbalance (HP:0002141)2.20907709
105Chronic hepatic failure (HP:0100626)2.19857585
106Polydipsia (HP:0001959)2.19100981
107Abnormal drinking behavior (HP:0030082)2.19100981
108Papilledema (HP:0001085)2.14561106
109Rimmed vacuoles (HP:0003805)2.13849465
110Incomplete penetrance (HP:0003829)2.12376935
111Lower limb muscle weakness (HP:0007340)2.08248827
112Type II lissencephaly (HP:0007260)2.04507737
113Blue irides (HP:0000635)2.04107171
114Ventricular fibrillation (HP:0001663)2.04073682
115Hypsarrhythmia (HP:0002521)2.01099481
116Decreased central vision (HP:0007663)1.99669905
117Protruding tongue (HP:0010808)1.99193578
118Abolished electroretinogram (ERG) (HP:0000550)1.99186185
119Sclerocornea (HP:0000647)1.98755882
120Polyuria (HP:0000103)1.98210139
121Insidious onset (HP:0003587)1.97680275
122Termporal pattern (HP:0011008)1.97680275
123Inability to walk (HP:0002540)1.97278397
124Neuronal loss in central nervous system (HP:0002529)1.96954978
125Chronic bronchitis (HP:0004469)1.95879219
126Congenital hepatic fibrosis (HP:0002612)1.95356056
127Megalencephaly (HP:0001355)1.95266112
128Hyporeflexia of lower limbs (HP:0002600)1.95099195
129Attenuation of retinal blood vessels (HP:0007843)1.94372712
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.93884144
131Limb dystonia (HP:0002451)1.93733428
132Syncope (HP:0001279)1.92159168
133EMG: myopathic abnormalities (HP:0003458)1.91179711
134Congenital primary aphakia (HP:0007707)1.90851179
135Abnormality of the corticospinal tract (HP:0002492)1.89076137
136Abnormality of salivation (HP:0100755)1.87244352
137Decreased circulating renin level (HP:0003351)1.86981642
138Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84159588
139Hip contracture (HP:0003273)1.82979215
140Difficulty running (HP:0009046)1.81989128
141Generalized myoclonic seizures (HP:0002123)1.81267245
142Areflexia of lower limbs (HP:0002522)1.81183388
143Aqueductal stenosis (HP:0002410)1.79379932
144Bronchiectasis (HP:0002110)1.79300833
145Anencephaly (HP:0002323)1.78834012
146Gait ataxia (HP:0002066)1.77600406
147Ulnar deviation of the wrist (HP:0003049)1.77255409
148Clonus (HP:0002169)1.76446427
149Nephrogenic diabetes insipidus (HP:0009806)1.76425491
150Bundle branch block (HP:0011710)1.75817685
151Increased corneal curvature (HP:0100692)1.75401701
152Keratoconus (HP:0000563)1.75401701
153Optic nerve hypoplasia (HP:0000609)1.74874963
154Neoplasm of the heart (HP:0100544)1.74702824
155Genital tract atresia (HP:0001827)1.74689514
156Deeply set eye (HP:0000490)1.74199968
157Autism (HP:0000717)1.74198309
158Truncus arteriosus (HP:0001660)1.74011672
159Generalized hypopigmentation of hair (HP:0011358)1.73787094
160Male pseudohermaphroditism (HP:0000037)1.73340550
161Primary atrial arrhythmia (HP:0001692)1.73154562
162Insomnia (HP:0100785)1.72962279
163Myopathic facies (HP:0002058)1.72626084
164Psychosis (HP:0000709)1.72350026
165Frequent falls (HP:0002359)1.72210485
166Furrowed tongue (HP:0000221)1.71945060
167Postaxial foot polydactyly (HP:0001830)1.71053440
168Fair hair (HP:0002286)1.70560688
169Abnormality of oral frenula (HP:0000190)1.70451203
170Malignant hyperthermia (HP:0002047)1.69197230
171Inappropriate behavior (HP:0000719)1.69126056
172Central scotoma (HP:0000603)1.68530402
173Bowel incontinence (HP:0002607)1.67961694
174Occipital encephalocele (HP:0002085)1.67619158
175Abnormal rod and cone electroretinograms (HP:0008323)1.66470759
176Vaginal atresia (HP:0000148)1.66241194
177Neck muscle weakness (HP:0000467)1.64803968
178Left ventricular hypertrophy (HP:0001712)1.63653455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.42876759
2NTRK35.08757839
3OBSCN5.03179069
4FRK4.33859924
5MAP3K93.17539343
6RIPK43.03927725
7MAP3K42.53334559
8MINK12.49541117
9GRK12.38000188
10MARK12.37679599
11NTRK22.25127094
12KSR12.24965941
13NTRK12.23849381
14TNIK2.23446958
15ADRBK22.05981849
16KSR22.05826648
17DAPK22.05759087
18MAP2K71.97150884
19INSRR1.93501045
20BMPR1B1.87629429
21WNK31.85467433
22PAK61.84531418
23PRKD31.79895582
24MAP4K21.67228337
25CAMKK11.67129132
26SIK21.63517560
27CASK1.58195636
28FES1.57695521
29CDK51.54218016
30MAP3K131.49576645
31DAPK11.49080527
32PRPF4B1.47342201
33MAPK151.47210540
34MAP2K41.41791991
35STK381.38213338
36PNCK1.29405030
37BMPR21.28039729
38STK391.24312721
39MAPK131.19540180
40ARAF1.18052642
41PIK3CG1.17564291
42PRKCG1.15271960
43CAMK2A1.12067374
44TAOK31.11078346
45MAP3K121.10652103
46PLK21.10092082
47WNK41.09271798
48TIE11.08201905
49PKN11.07645409
50CCNB11.07389058
51MUSK1.05968174
52CAMK2B1.05742906
53PTK2B1.04500821
54RAF11.01932432
55TYRO31.00749375
56GRK50.98541282
57CAMKK20.93159874
58ACVR1B0.91987088
59NUAK10.90991786
60SGK2230.88994930
61SGK4940.88994930
62SIK30.87950840
63SGK10.87100623
64TNK20.86003590
65CAMK10.85662009
66MAP3K20.85419882
67SGK20.85365054
68ZAK0.83111700
69TAOK10.82917668
70CDK180.81016907
71STK110.76403555
72CDK150.76038116
73DMPK0.74333812
74NEK60.74150740
75MARK20.72428057
76PRKCH0.72205209
77PINK10.72177068
78CDK140.71031934
79UHMK10.70846141
80ADRBK10.70645544
81TTN0.70150402
82MAPK120.69602490
83SGK30.68246663
84DYRK20.67924514
85MAPKAPK30.67163905
86MAPKAPK50.66410135
87FGFR20.65146309
88CDK11A0.65008695
89PIK3CA0.64973195
90DYRK1A0.64895691
91NME10.64873790
92FGR0.64305713
93CSNK1G10.63708926
94MKNK20.63510750
95CAMK2D0.62890205
96BCR0.61910687
97PRKG10.61630974
98STK38L0.61541583
99PHKG20.61356785
100PHKG10.61356785
101ERBB30.61249074
102MAP3K70.60304041
103RET0.57430409
104CDC42BPA0.57099708
105PRKAA10.56277725
106RPS6KA30.55178304
107PAK30.54980037
108PDPK10.54912303
109PRKCZ0.54820218
110MAPK100.54553725
111FYN0.53853227
112LMTK20.53811279
113PDK10.53429320
114PRKCE0.52447945
115CAMK1G0.52213203
116TGFBR10.51418536
117ROCK10.49221086
118PRKAA20.48073283
119CDK190.47457592
120TLK10.46479288
121WNK10.46131954
122MAP3K10.45217722
123CSNK1G30.43214486
124CAMK2G0.42911190
125FER0.41062185
126AKT30.40783218
127CSNK1A10.40571774
128ALK0.39847663
129PRKACB0.39730300
130PRKCB0.38796415
131CSNK1D0.38117509
132MAP2K10.37531421
133ROCK20.36963745
134OXSR10.36525250
135PRKD20.36060496
136CSNK1A1L0.35474067
137PRKACA0.34920593
138CSNK1G20.34561754
139LATS20.34487215
140TRPM70.34134181
141MAP2K60.33950998
142TRIM280.33686452
143PRKCA0.32854857
144ERBB20.32809795
145CAMK40.31690830
146PRKCQ0.28970111
147CSNK1E0.28242244

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.12131160
2Olfactory transduction_Homo sapiens_hsa047402.93755046
3Morphine addiction_Homo sapiens_hsa050322.85207252
4* Circadian entrainment_Homo sapiens_hsa047132.82297168
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82000886
6GABAergic synapse_Homo sapiens_hsa047272.81424796
7Long-term potentiation_Homo sapiens_hsa047202.81200528
8Glutamatergic synapse_Homo sapiens_hsa047242.73568434
9Amphetamine addiction_Homo sapiens_hsa050312.68387067
10Synaptic vesicle cycle_Homo sapiens_hsa047212.63814400
11Dopaminergic synapse_Homo sapiens_hsa047282.28405589
12* Salivary secretion_Homo sapiens_hsa049702.19347920
13Cholinergic synapse_Homo sapiens_hsa047252.00880324
14Cocaine addiction_Homo sapiens_hsa050302.00455783
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97302751
16Renin secretion_Homo sapiens_hsa049241.94291055
17Insulin secretion_Homo sapiens_hsa049111.93180726
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88834714
19Taste transduction_Homo sapiens_hsa047421.87362390
20Linoleic acid metabolism_Homo sapiens_hsa005911.83137408
21* Calcium signaling pathway_Homo sapiens_hsa040201.83039396
22Serotonergic synapse_Homo sapiens_hsa047261.77489795
23Gastric acid secretion_Homo sapiens_hsa049711.77429679
24* Oxytocin signaling pathway_Homo sapiens_hsa049211.72157250
25Long-term depression_Homo sapiens_hsa047301.70601450
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67364538
27Butanoate metabolism_Homo sapiens_hsa006501.62895956
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53817393
29Histidine metabolism_Homo sapiens_hsa003401.51685326
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51185454
31cAMP signaling pathway_Homo sapiens_hsa040241.45671896
32GnRH signaling pathway_Homo sapiens_hsa049121.41325892
33Gap junction_Homo sapiens_hsa045401.40054333
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39786182
35Tryptophan metabolism_Homo sapiens_hsa003801.22744552
36beta-Alanine metabolism_Homo sapiens_hsa004101.22345830
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21642277
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21399844
39Propanoate metabolism_Homo sapiens_hsa006401.20597221
40Caffeine metabolism_Homo sapiens_hsa002321.19682356
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18543535
42Axon guidance_Homo sapiens_hsa043601.17805352
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16827908
44Type II diabetes mellitus_Homo sapiens_hsa049301.13652096
45Ether lipid metabolism_Homo sapiens_hsa005651.11187013
46Estrogen signaling pathway_Homo sapiens_hsa049151.08549817
47Glioma_Homo sapiens_hsa052141.08105625
48Oxidative phosphorylation_Homo sapiens_hsa001901.07225244
49Phototransduction_Homo sapiens_hsa047441.06717031
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06669093
51Melanogenesis_Homo sapiens_hsa049161.05466581
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.04584976
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03233524
54ABC transporters_Homo sapiens_hsa020101.03021973
55Collecting duct acid secretion_Homo sapiens_hsa049661.02723999
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01551829
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00827541
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98685073
59Parkinsons disease_Homo sapiens_hsa050120.98533626
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97927610
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97578773
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.97561875
63Chemical carcinogenesis_Homo sapiens_hsa052040.96711046
64Cardiac muscle contraction_Homo sapiens_hsa042600.95886293
65ErbB signaling pathway_Homo sapiens_hsa040120.95607586
66Pancreatic secretion_Homo sapiens_hsa049720.95235835
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95168426
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.92492376
69Dilated cardiomyopathy_Homo sapiens_hsa054140.90711123
70Alzheimers disease_Homo sapiens_hsa050100.85826680
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83492314
72Choline metabolism in cancer_Homo sapiens_hsa052310.83401356
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81471766
74Oocyte meiosis_Homo sapiens_hsa041140.79916177
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79885813
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79261686
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78727270
78Huntingtons disease_Homo sapiens_hsa050160.77585661
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.77078863
80Dorso-ventral axis formation_Homo sapiens_hsa043200.76627786
81Arginine and proline metabolism_Homo sapiens_hsa003300.75438576
82Thyroid hormone synthesis_Homo sapiens_hsa049180.75144257
83Peroxisome_Homo sapiens_hsa041460.72357303
84MAPK signaling pathway_Homo sapiens_hsa040100.71596593
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.67066668
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66134191
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66089896
88Retinol metabolism_Homo sapiens_hsa008300.65059852
89Glycerolipid metabolism_Homo sapiens_hsa005610.64634856
90Fatty acid biosynthesis_Homo sapiens_hsa000610.64520856
91Rap1 signaling pathway_Homo sapiens_hsa040150.64400552
92VEGF signaling pathway_Homo sapiens_hsa043700.62957689
93Circadian rhythm_Homo sapiens_hsa047100.62759682
94Alcoholism_Homo sapiens_hsa050340.60631163
95Ras signaling pathway_Homo sapiens_hsa040140.59072142
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57732657
97Fatty acid degradation_Homo sapiens_hsa000710.57237829
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56556149
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56493187
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56223299
101Vibrio cholerae infection_Homo sapiens_hsa051100.55993172
102Hedgehog signaling pathway_Homo sapiens_hsa043400.55301945
103Glucagon signaling pathway_Homo sapiens_hsa049220.53496290
104Non-small cell lung cancer_Homo sapiens_hsa052230.52784997
105Inositol phosphate metabolism_Homo sapiens_hsa005620.51886314
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51313365
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51161694
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.50703266
109Arachidonic acid metabolism_Homo sapiens_hsa005900.50250937
110Nitrogen metabolism_Homo sapiens_hsa009100.48725254
111African trypanosomiasis_Homo sapiens_hsa051430.48689345
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48470446
113Fanconi anemia pathway_Homo sapiens_hsa034600.48075801
114mTOR signaling pathway_Homo sapiens_hsa041500.46466535
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.45459025
116Bile secretion_Homo sapiens_hsa049760.45334646
117Tight junction_Homo sapiens_hsa045300.44110513
118Wnt signaling pathway_Homo sapiens_hsa043100.43900415
119Type I diabetes mellitus_Homo sapiens_hsa049400.43568310
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42992736
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42827859
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42489967
123Chemokine signaling pathway_Homo sapiens_hsa040620.42314963
124Basal transcription factors_Homo sapiens_hsa030220.39779216
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36747139
126Ovarian steroidogenesis_Homo sapiens_hsa049130.36566177
127Purine metabolism_Homo sapiens_hsa002300.35638624
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33193690
129Endocytosis_Homo sapiens_hsa041440.31633959
130Prion diseases_Homo sapiens_hsa050200.31562999
131Endometrial cancer_Homo sapiens_hsa052130.29610402
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29524863
133Mineral absorption_Homo sapiens_hsa049780.29264063
134Renal cell carcinoma_Homo sapiens_hsa052110.29069181
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28865624
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27553504
137Insulin signaling pathway_Homo sapiens_hsa049100.26943853
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.25767262
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25755081
140Platelet activation_Homo sapiens_hsa046110.25133869

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »