S100A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle contraction (GO:0003009)6.26291522
2actin filament-based movement (GO:0030048)5.27896991
3sarcomere organization (GO:0045214)5.10827480
4cardiac myofibril assembly (GO:0055003)4.53489745
5response to muscle activity (GO:0014850)4.50316051
6muscle contraction (GO:0006936)4.49664281
7membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.44909999
8response to inactivity (GO:0014854)4.37719564
9myofibril assembly (GO:0030239)4.35127246
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.15609348
11muscle system process (GO:0003012)4.02754975
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.99610559
13regulation of actin filament-based movement (GO:1903115)3.97452478
14tricarboxylic acid cycle (GO:0006099)3.94557340
15regulation of sequestering of triglyceride (GO:0010889)3.92114994
16glycogen catabolic process (GO:0005980)3.91821602
17cardiac muscle hypertrophy in response to stress (GO:0014898)3.88959963
18muscle hypertrophy in response to stress (GO:0003299)3.88959963
19cardiac muscle adaptation (GO:0014887)3.88959963
20cell communication by electrical coupling (GO:0010644)3.82701500
21fatty acid beta-oxidation (GO:0006635)3.82248152
22creatine metabolic process (GO:0006600)3.79694850
23regulation of membrane repolarization (GO:0060306)3.78506754
24regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.75199135
25negative regulation of potassium ion transmembrane transport (GO:1901380)3.74038635
26regulation of skeletal muscle contraction (GO:0014819)3.73124564
27skeletal muscle fiber development (GO:0048741)3.70570355
28actin-myosin filament sliding (GO:0033275)3.69206749
29muscle filament sliding (GO:0030049)3.69206749
30striated muscle adaptation (GO:0014888)3.67670828
31respiratory electron transport chain (GO:0022904)3.66316469
32regulation of relaxation of muscle (GO:1901077)3.65023755
33glucan catabolic process (GO:0009251)3.64104991
34heart contraction (GO:0060047)3.60881773
35heart process (GO:0003015)3.60881773
36regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.59937776
37* regulation of calcium ion transmembrane transport (GO:1903169)3.58974430
38* regulation of calcium ion transmembrane transporter activity (GO:1901019)3.58974430
39bundle of His cell to Purkinje myocyte communication (GO:0086069)3.57972446
40positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.57971175
41negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.55582409
42negative regulation of calcium ion transmembrane transport (GO:1903170)3.55582409
43electron transport chain (GO:0022900)3.55228837
44skeletal muscle adaptation (GO:0043501)3.53976362
45carnitine shuttle (GO:0006853)3.52938860
46cardiac muscle contraction (GO:0060048)3.50655410
47detection of calcium ion (GO:0005513)3.43723788
48negative regulation of protein localization to cell surface (GO:2000009)3.42117301
49fatty acid transmembrane transport (GO:1902001)3.41425940
50aspartate family amino acid catabolic process (GO:0009068)3.40010948
51cellular polysaccharide catabolic process (GO:0044247)3.38391822
52ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.35927025
53ATP synthesis coupled proton transport (GO:0015986)3.35759724
54energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35759724
552-oxoglutarate metabolic process (GO:0006103)3.34224765
56fatty acid catabolic process (GO:0009062)3.34189102
57lipid oxidation (GO:0034440)3.31527942
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31231241
59cardiac muscle tissue morphogenesis (GO:0055008)3.31093659
60fatty acid oxidation (GO:0019395)3.29167078
61myotube cell development (GO:0014904)3.28206580
62oxaloacetate metabolic process (GO:0006107)3.26536981
63adult heart development (GO:0007512)3.25443929
64regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.23993211
65* positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.23954722
66branched-chain amino acid catabolic process (GO:0009083)3.21597660
67gluconeogenesis (GO:0006094)3.19623268
68glycogen biosynthetic process (GO:0005978)3.18974083
69glucan biosynthetic process (GO:0009250)3.18974083
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.18450597
71cardiac muscle cell development (GO:0055013)3.11653070
72regulation of heart rate (GO:0002027)3.10639380
73regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.10330807
74muscle fiber development (GO:0048747)3.09891544
75short-chain fatty acid metabolic process (GO:0046459)3.09338612
76regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.09289322
77actomyosin structure organization (GO:0031032)3.08964696
78muscle cell cellular homeostasis (GO:0046716)3.08926737
79polysaccharide catabolic process (GO:0000272)3.07941677
80ventricular cardiac muscle cell action potential (GO:0086005)3.07000545
81cardiac muscle cell action potential (GO:0086001)3.06554025
82actin-mediated cell contraction (GO:0070252)3.06113776
83lysine catabolic process (GO:0006554)3.04341465
84lysine metabolic process (GO:0006553)3.04341465
85cardiac muscle cell action potential involved in contraction (GO:0086002)3.03751627
86regulation of cardiac muscle cell contraction (GO:0086004)3.03353384
87plasma membrane repair (GO:0001778)3.02846765
88regulation of ATPase activity (GO:0043462)3.02785464
89regulation of ATP catabolic process (GO:1903289)3.02785464
90relaxation of muscle (GO:0090075)3.02436746
91sodium ion export (GO:0071436)3.01181737
92cardiac cell development (GO:0055006)2.99849549
93regulation of striated muscle contraction (GO:0006942)2.99718469
94regulation of lipoprotein metabolic process (GO:0050746)2.98994690
95heart trabecula formation (GO:0060347)2.96544226
96cellular response to epinephrine stimulus (GO:0071872)2.96170035
97positive regulation of sodium ion transport (GO:0010765)2.95658849
98monocarboxylic acid catabolic process (GO:0072329)2.94946906
99* regulation of heart contraction (GO:0008016)2.94912163
100muscle tissue morphogenesis (GO:0060415)2.94546479
101regulation of sodium ion transmembrane transport (GO:1902305)2.94530282
102branched-chain amino acid metabolic process (GO:0009081)2.94493583
103response to epinephrine (GO:0071871)2.93921031
104sarcoplasmic reticulum calcium ion transport (GO:0070296)2.93755149
105muscle adaptation (GO:0043500)2.92905016
106skeletal muscle tissue development (GO:0007519)2.92717917
107negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.92406432
108carnitine transmembrane transport (GO:1902603)2.92272648
109hexose biosynthetic process (GO:0019319)2.86004041
110amino-acid betaine transport (GO:0015838)2.83747123
111carnitine transport (GO:0015879)2.83747123
112valine metabolic process (GO:0006573)2.83184136
113fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.82254776
114regulation of fatty acid oxidation (GO:0046320)2.79460739
115cardiac muscle hypertrophy (GO:0003300)2.78764191
116acetyl-CoA metabolic process (GO:0006084)2.77665540
117cellular ketone body metabolic process (GO:0046950)2.74404615
118axon ensheathment in central nervous system (GO:0032291)2.74002470
119central nervous system myelination (GO:0022010)2.74002470
120biotin metabolic process (GO:0006768)2.71279743
121response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.70975278
122regulation of acyl-CoA biosynthetic process (GO:0050812)2.70799566
123regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.67960498
124striated muscle hypertrophy (GO:0014897)2.65511025
125striated muscle contraction (GO:0006941)2.65486568
126tricarboxylic acid metabolic process (GO:0072350)2.64421426
127muscle hypertrophy (GO:0014896)2.63284689
128regulation of cardiac muscle contraction (GO:0055117)2.62998258
129regulation of the force of heart contraction (GO:0002026)2.62874663
130regulation of coenzyme metabolic process (GO:0051196)2.62573768
131regulation of cofactor metabolic process (GO:0051193)2.62573768
132regulation of cell communication by electrical coupling (GO:0010649)2.60451736
133regulation of sarcomere organization (GO:0060297)2.58370331
134carnitine metabolic process (GO:0009437)2.56505190
135ethanol oxidation (GO:0006069)2.53897797
136oxidative phosphorylation (GO:0006119)2.48463288
137relaxation of cardiac muscle (GO:0055119)2.48434787
138cell communication involved in cardiac conduction (GO:0086065)2.47561126
139positive regulation of fatty acid oxidation (GO:0046321)2.47327188
140glyoxylate metabolic process (GO:0046487)2.46552750
141cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.46247813
142quaternary ammonium group transport (GO:0015697)2.42561025
143regulation of triglyceride catabolic process (GO:0010896)2.41393940
144thyroid hormone generation (GO:0006590)2.40948280
145L-phenylalanine catabolic process (GO:0006559)2.39604360
146erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.39604360
147response to mercury ion (GO:0046689)2.38636275
148NADH metabolic process (GO:0006734)2.38620718
149ketone body metabolic process (GO:1902224)2.37358441
150regulation of cholesterol metabolic process (GO:0090181)2.34840711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.51305502
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.14625027
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.45745132
4EZH2_22144423_ChIP-Seq_EOC_Human3.39600279
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.89560929
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.68766709
7* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.67927227
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.62240765
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.60308007
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.53984041
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.52850280
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.50882114
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46449207
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.24402724
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14694199
16TBX20_22328084_ChIP-Seq_HEART_Mouse2.13583519
17TBX20_22080862_ChIP-Seq_HEART_Mouse2.13583519
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.07565752
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.06715768
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.02235928
21ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.97198183
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91844101
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88508303
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87012866
25DROSHA_22980978_ChIP-Seq_HELA_Human1.84387191
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.83603443
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82064001
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.76719879
29* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69194454
30* CTCF_27219007_Chip-Seq_Bcells_Human1.67994356
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67932292
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.67648452
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65050079
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62911942
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60680987
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60680987
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.58032470
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55138441
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55138441
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.53336560
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53163118
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50813620
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50453840
44KDM2B_26808549_Chip-Seq_K562_Human1.49859947
45CLOCK_20551151_ChIP-Seq_293T_Human1.49472601
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49160954
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45238250
48* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44286267
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.41844053
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.41686235
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41641730
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.40194332
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39770643
54NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38724464
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36842454
56SMC4_20622854_ChIP-Seq_HELA_Human1.35960488
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35661165
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33147725
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29441518
60KDM2B_26808549_Chip-Seq_DND41_Human1.29439019
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29233241
62* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28621900
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28284733
64* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26851155
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24594886
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24437964
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23660990
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22895631
69NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21115525
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20904594
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.17438279
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.17139326
73STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.16986367
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.16611148
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12786577
76SOX2_20726797_ChIP-Seq_SW620_Human1.12575561
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12132064
78CJUN_26792858_Chip-Seq_BT549_Human1.11002016
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.07865660
80P68_20966046_ChIP-Seq_HELA_Human1.07684955
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.06873995
82TCF7_22412390_ChIP-Seq_EML_Mouse1.06620112
83* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06381178
84MYC_27129775_Chip-Seq_CORNEA_Mouse1.06160113
85ZNF263_19887448_ChIP-Seq_K562_Human1.05552522
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.05293267
87VDR_24787735_ChIP-Seq_THP-1_Human1.04448236
88SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03987002
89* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03922135
90JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02740532
91TP53_23651856_ChIP-Seq_MEFs_Mouse1.01760451
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.00956757
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00287846
94AR_21572438_ChIP-Seq_LNCaP_Human1.00271484
95P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99728373
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98557597
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97860534
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97669488
99ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97478577
100OCT4_19829295_ChIP-Seq_ESCs_Human0.95886519
101CREB1_26743006_Chip-Seq_LNCaP_Human0.95577657
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95345133
103* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94386982
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94192864
105WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94036550
106* SA1_27219007_Chip-Seq_Bcells_Human0.93912457
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93812020
108GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93477766
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93270497
110MITF_21258399_ChIP-Seq_MELANOMA_Human0.92182424
111MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91924151
112OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91911760
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90882686
114EGR1_19032775_ChIP-ChIP_M12_Human0.90548658
115NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88526251
116IRF8_27001747_Chip-Seq_BMDM_Mouse0.87372791
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87284804
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86968257
119* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86401607
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85278186
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84431853
122MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84357565
123GATA1_19941826_ChIP-Seq_K562_Human0.84275822
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84014451
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83484351
126IRF8_21731497_ChIP-ChIP_J774_Mouse0.83476203
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83394128
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82693751
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82515774
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81861701
131SMC3_22415368_ChIP-Seq_MEFs_Mouse0.79588816
132GATA2_19941826_ChIP-Seq_K562_Human0.77610875
133ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76692910
134TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.76365848
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75984670
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.75383278
137* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75269869
138JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74959747
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.74502845
140GATA4_21415370_ChIP-Seq_HL-1_Mouse0.74116926
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74039926
142BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72549321
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.72299291
144CDX2_20551321_ChIP-Seq_CACO-2_Human0.71487422
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70678818
146LXR_22292898_ChIP-Seq_THP-1_Human0.70357158
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70218689
148SMC1_22415368_ChIP-Seq_MEFs_Mouse0.69995697
149ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69386783
150SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.68942393
151GATA4_25053715_ChIP-Seq_YYC3_Human0.68832134
152TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.68390821
153CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68183267
154* RACK7_27058665_Chip-Seq_MCF-7_Human0.67418592
155GATA3_24758297_ChIP-Seq_MCF-7_Human0.66908412
156CSB_26484114_Chip-Seq_FIBROBLAST_Human0.66661866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.54433941
2MP0003646_muscle_fatigue4.47212932
3MP0004084_abnormal_cardiac_muscle4.04539862
4MP0000751_myopathy3.35316209
5MP0004036_abnormal_muscle_relaxation3.22887205
6MP0004215_abnormal_myocardial_fiber3.20481225
7MP0000749_muscle_degeneration2.97648542
8MP0005330_cardiomyopathy2.90962356
9MP0004130_abnormal_muscle_cell2.49374870
10* MP0002972_abnormal_cardiac_muscle2.40276824
11MP0008775_abnormal_heart_ventricle2.31990530
12MP0004043_abnormal_pH_regulation2.19085766
13MP0004087_abnormal_muscle_fiber2.13029019
14MP0004233_abnormal_muscle_weight2.10613868
15MP0005385_cardiovascular_system_phenoty2.01369651
16MP0001544_abnormal_cardiovascular_syste2.01369651
17MP0004270_analgesia1.95143173
18MP0000750_abnormal_muscle_regeneration1.88983403
19MP0003137_abnormal_impulse_conducting1.88285453
20MP0003195_calcinosis1.84605630
21* MP0005620_abnormal_muscle_contractility1.83484824
22MP0006138_congestive_heart_failure1.81209467
23MP0005670_abnormal_white_adipose1.79717383
24MP0000343_altered_response_to1.77682701
25MP0005666_abnormal_adipose_tissue1.76205207
26MP0003828_pulmonary_edema1.75833175
27MP0004484_altered_response_of1.74864963
28MP0003806_abnormal_nucleotide_metabolis1.74642119
29MP0009840_abnormal_foam_cell1.73850440
30MP0003690_abnormal_glial_cell1.72797859
31MP0010630_abnormal_cardiac_muscle1.72295319
32MP0006036_abnormal_mitochondrial_physio1.64707253
33MP0003186_abnormal_redox_activity1.63898502
34MP0004859_abnormal_synaptic_plasticity1.58568594
35MP0004510_myositis1.57919379
36MP0005058_abnormal_lysosome_morphology1.56592278
37MP0002139_abnormal_hepatobiliary_system1.56366287
38MP0003950_abnormal_plasma_membrane1.54628580
39MP0004185_abnormal_adipocyte_glucose1.52657249
40* MP0002106_abnormal_muscle_physiology1.50490775
41MP0002108_abnormal_muscle_morphology1.47894789
42MP0008569_lethality_at_weaning1.47274546
43MP0005165_increased_susceptibility_to1.40742484
44MP0009780_abnormal_chondrocyte_physiolo1.38481605
45MP0005085_abnormal_gallbladder_physiolo1.33736004
46MP0000733_abnormal_muscle_development1.32586651
47MP0000920_abnormal_myelination1.31532769
48MP0005360_urolithiasis1.30617734
49MP0002269_muscular_atrophy1.29699448
50MP0004085_abnormal_heartbeat1.29622965
51MP0003191_abnormal_cellular_cholesterol1.29495549
52MP0008875_abnormal_xenobiotic_pharmacok1.27829103
53MP0005332_abnormal_amino_acid1.27366016
54MP0003279_aneurysm1.26102885
55MP0000747_muscle_weakness1.24558800
56MP0002332_abnormal_exercise_endurance1.24411294
57MP0008438_abnormal_cutaneous_collagen1.22312961
58* MP0005369_muscle_phenotype1.21591301
59MP0000013_abnormal_adipose_tissue1.17532389
60MP0000759_abnormal_skeletal_muscle1.16251683
61MP0005375_adipose_tissue_phenotype1.14007890
62MP0005365_abnormal_bile_salt1.12832127
63MP0005423_abnormal_somatic_nervous1.12724544
64MP0002295_abnormal_pulmonary_circulatio1.11606212
65MP0003221_abnormal_cardiomyocyte_apopto1.11105889
66MP0002118_abnormal_lipid_homeostasis1.09341155
67MP0009643_abnormal_urine_homeostasis1.09115050
68MP0005319_abnormal_enzyme/_coenzyme1.07265499
69MP0005584_abnormal_enzyme/coenzyme_acti1.07030220
70MP0000003_abnormal_adipose_tissue1.06705723
71MP0010368_abnormal_lymphatic_system1.05808802
72MP0003075_altered_response_to1.03750431
73MP0003724_increased_susceptibility_to1.02670204
74MP0003879_abnormal_hair_cell1.00785801
75MP0005409_darkened_coat_color1.00359817
76MP0004381_abnormal_hair_follicle0.97806144
77MP0000230_abnormal_systemic_arterial0.94670967
78MP0001879_abnormal_lymphatic_vessel0.93452839
79MP0003329_amyloid_beta_deposits0.92297447
80MP0005167_abnormal_blood-brain_barrier0.92288971
81MP0002064_seizures0.91773723
82MP0010329_abnormal_lipoprotein_level0.91694250
83MP0005535_abnormal_body_temperature0.90946397
84MP0001853_heart_inflammation0.88396306
85MP0003878_abnormal_ear_physiology0.87117850
86MP0005377_hearing/vestibular/ear_phenot0.87117850
87MP0001958_emphysema0.86755388
88MP0003635_abnormal_synaptic_transmissio0.84367161
89MP0002127_abnormal_cardiovascular_syste0.83048102
90MP0000604_amyloidosis0.82859298
91MP0004145_abnormal_muscle_electrophysio0.82096908
92MP0000372_irregular_coat_pigmentation0.81841996
93MP0002148_abnormal_hypersensitivity_rea0.80764075
94MP0002272_abnormal_nervous_system0.79381606
95MP0005451_abnormal_body_composition0.77962306
96MP0002971_abnormal_brown_adipose0.76944110
97MP0009764_decreased_sensitivity_to0.76810159
98MP0002822_catalepsy0.76358901
99MP0001485_abnormal_pinna_reflex0.72637917
100MP0000266_abnormal_heart_morphology0.70656529
101MP0003011_delayed_dark_adaptation0.69930934
102MP0002090_abnormal_vision0.69630032
103MP0003705_abnormal_hypodermis_morpholog0.68711908
104MP0005408_hypopigmentation0.67816284
105MP0003136_yellow_coat_color0.66823368
106MP0009745_abnormal_behavioral_response0.66543712
107MP0005083_abnormal_biliary_tract0.66273237
108MP0002734_abnormal_mechanical_nocicepti0.65780024
109MP0006082_CNS_inflammation0.65520619
110MP0002128_abnormal_blood_circulation0.65301653
111MP0003656_abnormal_erythrocyte_physiolo0.65249949
112MP0004272_abnormal_basement_membrane0.64089996
113MP0003172_abnormal_lysosome_physiology0.63719280
114MP0005171_absent_coat_pigmentation0.63276343
115MP0001756_abnormal_urination0.62818661
116MP0003045_fibrosis0.61561654
117MP0000767_abnormal_smooth_muscle0.61469450
118* MP0002063_abnormal_learning/memory/cond0.61198744
119MP0000249_abnormal_blood_vessel0.59891461
120MP0002066_abnormal_motor_capabilities/c0.59786313
121MP0001661_extended_life_span0.59586659
122MP0005266_abnormal_metabolism0.57645855
123MP0000609_abnormal_liver_physiology0.57422501
124MP0001502_abnormal_circadian_rhythm0.57245130
125MP0005166_decreased_susceptibility_to0.57015727
126MP0003634_abnormal_glial_cell0.56530943
127MP0001486_abnormal_startle_reflex0.55857368
128MP0002998_abnormal_bone_remodeling0.55757450
129MP0002078_abnormal_glucose_homeostasis0.55654658
130MP0008469_abnormal_protein_level0.54775881
131MP0001299_abnormal_eye_distance/0.53990855
132MP0001501_abnormal_sleep_pattern0.51588759
133MP0003633_abnormal_nervous_system0.47794534
134MP0004858_abnormal_nervous_system0.46922256
135MP0003880_abnormal_central_pattern0.42202384
136MP0002638_abnormal_pupillary_reflex0.41452452
137MP0008260_abnormal_autophagy0.40501661
138MP0001984_abnormal_olfaction0.38917405
139* MP0002572_abnormal_emotion/affect_behav0.38555264
140MP0004924_abnormal_behavior0.38398812
141MP0005386_behavior/neurological_phenoty0.38398812

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.71078701
2Nemaline bodies (HP:0003798)7.64407642
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.47768463
4Type 1 muscle fiber predominance (HP:0003803)6.58412059
5Sudden death (HP:0001699)5.23403315
6Ventricular tachycardia (HP:0004756)5.04477090
7Muscle fiber splitting (HP:0003555)4.77233223
8Calf muscle hypertrophy (HP:0008981)4.44399342
9Centrally nucleated skeletal muscle fibers (HP:0003687)4.34747153
10Myopathic facies (HP:0002058)4.34318447
11Exercise-induced muscle cramps (HP:0003710)4.24141188
12Atrial fibrillation (HP:0005110)4.22700549
13Abnormality of skeletal muscle fiber size (HP:0012084)4.11713142
14Neck muscle weakness (HP:0000467)4.09231693
15Muscle hypertrophy of the lower extremities (HP:0008968)4.05096085
16Exercise-induced myalgia (HP:0003738)3.99687485
17Lipoatrophy (HP:0100578)3.95522371
18Primary atrial arrhythmia (HP:0001692)3.86555062
19Right ventricular cardiomyopathy (HP:0011663)3.83423242
20Hyporeflexia of lower limbs (HP:0002600)3.81221756
21Myoglobinuria (HP:0002913)3.78805860
22Distal arthrogryposis (HP:0005684)3.78787426
23Increased variability in muscle fiber diameter (HP:0003557)3.76713421
24Abnormality of the calf musculature (HP:0001430)3.72131805
25Supraventricular tachycardia (HP:0004755)3.68966705
26Dilated cardiomyopathy (HP:0001644)3.64358867
27Round ear (HP:0100830)3.63013675
28Supraventricular arrhythmia (HP:0005115)3.60407405
29EMG: neuropathic changes (HP:0003445)3.51507440
30Palpitations (HP:0001962)3.50021017
31Abnormality of fatty-acid metabolism (HP:0004359)3.40783876
32Rimmed vacuoles (HP:0003805)3.40170132
33Hepatic necrosis (HP:0002605)3.39157793
34Ketoacidosis (HP:0001993)3.37113233
35Asymmetric septal hypertrophy (HP:0001670)3.34061527
36Hypoglycemic coma (HP:0001325)3.33598869
37Syncope (HP:0001279)3.22359757
38Axonal loss (HP:0003447)3.18547595
39Abnormality of dicarboxylic acid metabolism (HP:0010995)3.15829198
40Dicarboxylic aciduria (HP:0003215)3.15829198
41Ulnar deviation of the wrist (HP:0003049)3.14336104
42Abnormality of the left ventricular outflow tract (HP:0011103)3.12711012
43Subaortic stenosis (HP:0001682)3.12711012
44Areflexia of lower limbs (HP:0002522)3.11302693
45Distal lower limb amyotrophy (HP:0008944)3.07963862
46Acute necrotizing encephalopathy (HP:0006965)3.07930726
47Acute encephalopathy (HP:0006846)3.04109712
48Abnormality of the foot musculature (HP:0001436)3.01743123
49Abnormal mitochondria in muscle tissue (HP:0008316)2.99841048
50EMG: myopathic abnormalities (HP:0003458)2.98385791
51Increased muscle lipid content (HP:0009058)2.98013461
52Cerebral edema (HP:0002181)2.96152542
53Mildly elevated creatine phosphokinase (HP:0008180)2.93780164
54Ketosis (HP:0001946)2.91868602
55Frequent falls (HP:0002359)2.89742432
56Hepatocellular necrosis (HP:0001404)2.88984120
57Rhabdomyolysis (HP:0003201)2.87515178
58Prolonged QT interval (HP:0001657)2.85782408
59Foot dorsiflexor weakness (HP:0009027)2.84584748
60Bundle branch block (HP:0011710)2.83738109
61Bulbar palsy (HP:0001283)2.80846927
62Atrioventricular block (HP:0001678)2.77029433
63Mitochondrial inheritance (HP:0001427)2.76541018
64Heart block (HP:0012722)2.75374467
65Generalized aminoaciduria (HP:0002909)2.73864277
66Ragged-red muscle fibers (HP:0003200)2.69816399
67Hyperglycinuria (HP:0003108)2.63578147
68Ventricular arrhythmia (HP:0004308)2.63572528
69Abnormal atrioventricular conduction (HP:0005150)2.62181869
70Difficulty running (HP:0009046)2.59088228
71Generalized muscle weakness (HP:0003324)2.57674313
72Lower limb amyotrophy (HP:0007210)2.55284248
73Increased intramyocellular lipid droplets (HP:0012240)2.54706490
74Scapular winging (HP:0003691)2.51257295
75Progressive macrocephaly (HP:0004481)2.50670283
76Hyperammonemia (HP:0001987)2.49685666
77Abnormality of glycine metabolism (HP:0010895)2.44412224
78Abnormality of serine family amino acid metabolism (HP:0010894)2.44412224
79Increased CSF lactate (HP:0002490)2.41816321
80Increased connective tissue (HP:0009025)2.41369366
81Calcaneovalgus deformity (HP:0001848)2.40091728
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.35827537
83Difficulty climbing stairs (HP:0003551)2.34503825
84Respiratory failure (HP:0002878)2.32345130
85Esophageal neoplasm (HP:0100751)2.24436736
86Neoplasm of head and neck (HP:0012288)2.24436736
87Hypokalemic alkalosis (HP:0001949)2.23231726
88Lipid accumulation in hepatocytes (HP:0006561)2.21592955
89Lactic acidosis (HP:0003128)2.20995017
90Gowers sign (HP:0003391)2.19068769
91Nausea (HP:0002018)2.15897651
92Increased serum pyruvate (HP:0003542)2.13217801
93Abnormality of glycolysis (HP:0004366)2.13217801
94Limb-girdle muscle atrophy (HP:0003797)2.12304515
95Myotonia (HP:0002486)2.10237305
96Absent phalangeal crease (HP:0006109)2.07725637
97Lethargy (HP:0001254)2.06712061
98Deformed tarsal bones (HP:0008119)2.05707465
99Weak cry (HP:0001612)2.04438278
100Exercise intolerance (HP:0003546)2.04088269
101Metabolic acidosis (HP:0001942)2.03183850
102Cerebral hemorrhage (HP:0001342)2.01735647
103Spinal rigidity (HP:0003306)2.01533576
104Goiter (HP:0000853)2.01388036
105Vomiting (HP:0002013)2.01196437
106Respiratory distress (HP:0002098)2.01040980
107Palmoplantar keratoderma (HP:0000982)2.00598329
108Pheochromocytoma (HP:0002666)2.00031507
109Malignant hyperthermia (HP:0002047)1.99363495
110Hypoplastic ischia (HP:0003175)1.98753015
111Hyperlipoproteinemia (HP:0010980)1.98346187
112Conjunctival hamartoma (HP:0100780)1.98139632
113Progressive muscle weakness (HP:0003323)1.98020240
114Muscle stiffness (HP:0003552)1.97644693
115Distal lower limb muscle weakness (HP:0009053)1.96738273
116Xanthomatosis (HP:0000991)1.95856189
117Glycosuria (HP:0003076)1.95417921
118Abnormality of urine glucose concentration (HP:0011016)1.95417921
119Proximal amyotrophy (HP:0007126)1.92974648
120Left ventricular hypertrophy (HP:0001712)1.92043672
121Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90715146
122Hypoalphalipoproteinemia (HP:0003233)1.89922574
123Muscular dystrophy (HP:0003560)1.83510906
124Waddling gait (HP:0002515)1.83223347
125Pulmonary artery stenosis (HP:0004415)1.83152772
126Abnormal EKG (HP:0003115)1.83018968
127Neurofibrillary tangles (HP:0002185)1.82842470
128Renal Fanconi syndrome (HP:0001994)1.82090496
129Neuroendocrine neoplasm (HP:0100634)1.81148885
130Fetal akinesia sequence (HP:0001989)1.80710940
131Tinnitus (HP:0000360)1.80699793
132Increased hepatocellular lipid droplets (HP:0006565)1.79524879
133Steppage gait (HP:0003376)1.78933427
134Proximal tubulopathy (HP:0000114)1.78637843
135Ventricular fibrillation (HP:0001663)1.78534042
136Abnormality of the shoulder girdle musculature (HP:0001435)1.78472231
137Peripheral hypomyelination (HP:0007182)1.77258391
138Abnormality of the ischium (HP:0003174)1.75063435
139Hyperinsulinemic hypoglycemia (HP:0000825)1.74888045
140Sudden cardiac death (HP:0001645)1.74842828
141Bone cyst (HP:0012062)1.74583626
142Respiratory insufficiency due to muscle weakness (HP:0002747)1.72183198
143Large for gestational age (HP:0001520)1.72062374
144Methylmalonic aciduria (HP:0012120)1.71525273
145Slender build (HP:0001533)1.68351806
146Achilles tendon contracture (HP:0001771)1.66119008
147Hip contracture (HP:0003273)1.63979457
148Hyperkalemia (HP:0002153)1.59328727
149Cerebral aneurysm (HP:0004944)1.58769889
150Abnormal finger flexion creases (HP:0006143)1.58216571
151Fatigable weakness (HP:0003473)1.57493085
152Abnormality of the neuromuscular junction (HP:0003398)1.57493085
153Abnormality of the Achilles tendon (HP:0005109)1.53767146
154Abnormality of the salivary glands (HP:0010286)1.53414223
155Generalized amyotrophy (HP:0003700)1.51728756
156Stridor (HP:0010307)1.49430960
157Limb-girdle muscle weakness (HP:0003325)1.49097022
158Hypoplasia of the iris (HP:0007676)1.47910442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.16948949
2TTN3.99376972
3PHKG13.27571736
4PHKG23.27571736
5BCKDK3.24427284
6MYLK3.20185423
7MUSK2.63004663
8TRIB32.53070710
9STK392.29276973
10WNK42.26961152
11OBSCN2.19776752
12EPHB12.14259376
13PINK12.02544012
14TIE11.98772366
15PDK21.95430362
16PDK41.91833433
17PDK31.91833433
18DMPK1.87781877
19MARK11.79196001
20PIK3CA1.74477512
21PBK1.62869657
22GRK71.52122189
23ERN11.50589759
24MAPKAPK31.42035014
25ICK1.40898734
26PKN21.37671142
27PIK3CG1.37607941
28PKN11.35785264
29INSRR1.27867669
30PRKD11.27439538
31TRPM71.27058710
32EPHA41.23517849
33PAK61.19730431
34LIMK11.19160858
35PRKD31.18307116
36STK241.18305143
37SIK11.17323583
38PAK31.17283974
39PRPF4B1.15626352
40ILK1.15174169
41CAMK2D1.13571208
42MAP3K31.13431060
43DDR21.08637566
44IRAK31.06528619
45MST41.05178174
46TBK11.04628800
47TGFBR20.99647364
48LATS20.95117180
49EEF2K0.94629519
50NTRK30.93481353
51MAP3K60.93400784
52PRKG20.93108684
53KSR20.92582577
54DAPK20.91880074
55MAPK120.91142368
56MST1R0.90934090
57OXSR10.90843772
58CAMK10.88576379
59UHMK10.84868551
60CAMK2B0.83179514
61ABL20.83035998
62NME20.82698728
63MAP3K110.82271388
64ROCK10.81883460
65CAMK40.80914591
66DAPK30.79171796
67ROCK20.76046444
68MET0.75819493
69PRKCE0.74799822
70MAP2K60.74470418
71STK40.73553397
72RIPK10.72306887
73PDPK10.71802291
74LRRK20.69708533
75TESK10.69497810
76SGK30.69062620
77MAPKAPK50.68536936
78ARAF0.68424404
79AKT20.67286537
80MARK20.66664751
81PRKAA20.65424822
82MAP2K30.63233987
83WNK10.62882378
84MAP2K40.60005487
85MAPK70.59678136
86MAPK40.57982038
87MAP3K10.57000376
88MAP2K10.56208618
89JAK10.56158462
90MAP3K140.55889806
91CAMK1D0.55839744
92IRAK10.55762407
93NTRK10.54808069
94PDGFRB0.53423518
95DYRK1B0.52877793
96TAOK20.52139448
97CAMK2G0.51601811
98PRKCQ0.51567768
99NEK90.50599556
100MOS0.50514854
101IRAK20.50205286
102BLK0.49064107
103MAPK100.48856973
104PDGFRA0.48778602
105NEK10.48316312
106MAP3K130.48224428
107SGK20.48098858
108KDR0.48021658
109EPHA30.47846096
110IRAK40.47621775
111PTK60.47487852
112CAMK2A0.46565165
113PRKG10.46244776
114SGK10.45866506
115CDK50.45754567
116FGFR40.45442858
117RPS6KA60.44969384
118CDC42BPA0.44916201
119PRKACG0.44440251
120BMX0.44253015
121PRKAA10.44142853
122MAPK110.43856124
123IKBKE0.43285570
124NTRK20.42097627
125RPS6KA30.41705255
126FGFR30.41665033
127RPS6KC10.41185380
128RPS6KL10.41185380
129STK38L0.40974352
130PRKACA0.40804149
131MAPK150.40745322
132CSK0.40742858
133SGK2230.40001820
134SGK4940.40001820
135TYRO30.39626303
136TYK20.38844850
137PDK10.38602558
138JAK20.38192819
139PRKCD0.37203763
140GSK3A0.35431707
141RIPK40.35217835
142PRKCH0.33959277
143MAP2K20.33833793
144CAMKK10.33562580
145MAP3K70.33436158
146PRKACB0.32104508
147RET0.31993274
148PTK2B0.31810136
149MAP3K90.30923495
150EPHB20.30647646
151NME10.30316030
152STK380.30294287
153MAP3K20.29412867

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.29418281
2Propanoate metabolism_Homo sapiens_hsa006403.22358047
3Fatty acid degradation_Homo sapiens_hsa000713.18818252
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.94902362
5Oxidative phosphorylation_Homo sapiens_hsa001902.92390856
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.74332393
7Parkinsons disease_Homo sapiens_hsa050122.49645174
8Fatty acid metabolism_Homo sapiens_hsa012122.49588046
9Fatty acid elongation_Homo sapiens_hsa000622.36359669
10Cardiac muscle contraction_Homo sapiens_hsa042602.36071228
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.28312308
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06565520
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04289437
14Alzheimers disease_Homo sapiens_hsa050101.94399917
15Butanoate metabolism_Homo sapiens_hsa006501.92755606
16PPAR signaling pathway_Homo sapiens_hsa033201.89470503
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.89236706
18Nitrogen metabolism_Homo sapiens_hsa009101.85769482
19Carbon metabolism_Homo sapiens_hsa012001.74945605
20Circadian rhythm_Homo sapiens_hsa047101.74797212
21Peroxisome_Homo sapiens_hsa041461.73982607
22Sulfur metabolism_Homo sapiens_hsa009201.71867058
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66642435
24Dilated cardiomyopathy_Homo sapiens_hsa054141.65673816
25Glucagon signaling pathway_Homo sapiens_hsa049221.62198678
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.61504767
27Tryptophan metabolism_Homo sapiens_hsa003801.56936695
28Pyruvate metabolism_Homo sapiens_hsa006201.55565577
29Insulin signaling pathway_Homo sapiens_hsa049101.51777429
30Oxytocin signaling pathway_Homo sapiens_hsa049211.45242892
31beta-Alanine metabolism_Homo sapiens_hsa004101.43142726
32Calcium signaling pathway_Homo sapiens_hsa040201.42722747
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.40228457
34Long-term potentiation_Homo sapiens_hsa047201.39706790
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35925537
36Huntingtons disease_Homo sapiens_hsa050161.35634956
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.31308117
38Starch and sucrose metabolism_Homo sapiens_hsa005001.26151597
39Arginine biosynthesis_Homo sapiens_hsa002201.25164654
40Renin secretion_Homo sapiens_hsa049241.24651766
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.24345267
42Insulin secretion_Homo sapiens_hsa049111.23251107
43Histidine metabolism_Homo sapiens_hsa003401.21785759
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19497522
45Phenylalanine metabolism_Homo sapiens_hsa003601.18349402
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17754570
47Fatty acid biosynthesis_Homo sapiens_hsa000611.14754560
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10809401
49AMPK signaling pathway_Homo sapiens_hsa041521.09953598
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08976209
51Arginine and proline metabolism_Homo sapiens_hsa003301.07173338
52Circadian entrainment_Homo sapiens_hsa047131.05222202
53Tyrosine metabolism_Homo sapiens_hsa003501.05048295
54Chemical carcinogenesis_Homo sapiens_hsa052041.03949181
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03365228
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00911920
57Amphetamine addiction_Homo sapiens_hsa050310.99931495
58GnRH signaling pathway_Homo sapiens_hsa049120.98701112
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.98414124
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97510651
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89028011
62Other glycan degradation_Homo sapiens_hsa005110.88952773
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.88770122
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86756645
65Synaptic vesicle cycle_Homo sapiens_hsa047210.85003452
66cAMP signaling pathway_Homo sapiens_hsa040240.84500484
67Lysosome_Homo sapiens_hsa041420.83237556
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79536008
69Glutathione metabolism_Homo sapiens_hsa004800.79241597
70Salivary secretion_Homo sapiens_hsa049700.78137781
71GABAergic synapse_Homo sapiens_hsa047270.77918147
72Viral myocarditis_Homo sapiens_hsa054160.74581082
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73636108
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72594996
75Staphylococcus aureus infection_Homo sapiens_hsa051500.72023504
76Complement and coagulation cascades_Homo sapiens_hsa046100.71866565
77Biosynthesis of amino acids_Homo sapiens_hsa012300.70909610
78Cholinergic synapse_Homo sapiens_hsa047250.69344444
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67739264
80Steroid biosynthesis_Homo sapiens_hsa001000.67070612
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63681848
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62422584
83Melanogenesis_Homo sapiens_hsa049160.61718171
84Dopaminergic synapse_Homo sapiens_hsa047280.61418833
85Folate biosynthesis_Homo sapiens_hsa007900.61183248
86Tight junction_Homo sapiens_hsa045300.61047802
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60748661
88Caffeine metabolism_Homo sapiens_hsa002320.59504099
89Morphine addiction_Homo sapiens_hsa050320.59435059
90Sulfur relay system_Homo sapiens_hsa041220.59288589
91VEGF signaling pathway_Homo sapiens_hsa043700.58219051
92Insulin resistance_Homo sapiens_hsa049310.57945948
93Bile secretion_Homo sapiens_hsa049760.57287660
94Rheumatoid arthritis_Homo sapiens_hsa053230.56305834
95Retinol metabolism_Homo sapiens_hsa008300.55933399
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55585009
97Glutamatergic synapse_Homo sapiens_hsa047240.54495279
98Glycerolipid metabolism_Homo sapiens_hsa005610.54103326
99Glioma_Homo sapiens_hsa052140.54013715
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53491203
101Thyroid hormone synthesis_Homo sapiens_hsa049180.52663232
102Estrogen signaling pathway_Homo sapiens_hsa049150.52647414
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51625874
104Metabolic pathways_Homo sapiens_hsa011000.51108925
105Pancreatic secretion_Homo sapiens_hsa049720.48714658
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47352266
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46938991
108Galactose metabolism_Homo sapiens_hsa000520.45690889
109Cocaine addiction_Homo sapiens_hsa050300.44752972
110Fat digestion and absorption_Homo sapiens_hsa049750.44687011
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42899642
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42755655
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.41634502
114Malaria_Homo sapiens_hsa051440.41436010
115Collecting duct acid secretion_Homo sapiens_hsa049660.40295627
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.39859705
117Gap junction_Homo sapiens_hsa045400.39405387
118ECM-receptor interaction_Homo sapiens_hsa045120.39221358
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38022574
120ABC transporters_Homo sapiens_hsa020100.37657890
121Linoleic acid metabolism_Homo sapiens_hsa005910.37463029
122Ovarian steroidogenesis_Homo sapiens_hsa049130.36999528
123Ether lipid metabolism_Homo sapiens_hsa005650.36716408
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.34952930
125Arachidonic acid metabolism_Homo sapiens_hsa005900.34915306
126MAPK signaling pathway_Homo sapiens_hsa040100.34735535
127Phagosome_Homo sapiens_hsa041450.34611233
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33676438
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33329083
130Amoebiasis_Homo sapiens_hsa051460.33230999
131Mineral absorption_Homo sapiens_hsa049780.31801357
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.31711746
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.31399188
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31099817
135mTOR signaling pathway_Homo sapiens_hsa041500.31031559
136Autoimmune thyroid disease_Homo sapiens_hsa053200.29420785
137Prion diseases_Homo sapiens_hsa050200.29164400
138Pentose phosphate pathway_Homo sapiens_hsa000300.26338485
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.25822733
140Long-term depression_Homo sapiens_hsa047300.25175474
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24815025
142Lysine degradation_Homo sapiens_hsa003100.24561476
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.22950551
144Focal adhesion_Homo sapiens_hsa045100.22445981
145Sphingolipid metabolism_Homo sapiens_hsa006000.22166945
146Fructose and mannose metabolism_Homo sapiens_hsa000510.20649129
147Leishmaniasis_Homo sapiens_hsa051400.19055972
148Protein export_Homo sapiens_hsa030600.18657141
149Vitamin digestion and absorption_Homo sapiens_hsa049770.15315368
150Pertussis_Homo sapiens_hsa051330.14664190
151Graft-versus-host disease_Homo sapiens_hsa053320.13656659
152Gastric acid secretion_Homo sapiens_hsa049710.12648244

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