S100A13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.79071742
2central nervous system myelination (GO:0022010)6.79071742
3fatty acid elongation (GO:0030497)4.92853226
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.48492936
5protein maturation by protein folding (GO:0022417)4.33244707
6neutrophil activation involved in immune response (GO:0002283)4.16897127
7proteasome assembly (GO:0043248)3.92373368
8response to methylmercury (GO:0051597)3.75587733
9myelination (GO:0042552)3.72927252
10axon ensheathment (GO:0008366)3.70057140
11ensheathment of neurons (GO:0007272)3.70057140
12viral transcription (GO:0019083)3.68961341
13chaperone-mediated protein transport (GO:0072321)3.62891356
14cholesterol biosynthetic process (GO:0006695)3.61197470
15long-chain fatty acid biosynthetic process (GO:0042759)3.61177598
16COPI coating of Golgi vesicle (GO:0048205)3.59644334
17Golgi transport vesicle coating (GO:0048200)3.59644334
18amyloid precursor protein metabolic process (GO:0042982)3.56573865
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.54070846
20translational termination (GO:0006415)3.50326801
21membrane raft organization (GO:0031579)3.48494262
22cotranslational protein targeting to membrane (GO:0006613)3.48265770
23protein targeting to ER (GO:0045047)3.45588850
24ribosomal large subunit biogenesis (GO:0042273)3.41711163
25sterol biosynthetic process (GO:0016126)3.34486057
26protein localization to endoplasmic reticulum (GO:0070972)3.34132259
27protein retention in ER lumen (GO:0006621)3.32169592
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30418214
29ribosomal small subunit assembly (GO:0000028)3.28526103
30type B pancreatic cell proliferation (GO:0044342)3.24939818
31maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.17037309
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.15823718
33positive regulation of monocyte chemotaxis (GO:0090026)3.07843416
34translational elongation (GO:0006414)3.07811840
35regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.06216450
36maturation of SSU-rRNA (GO:0030490)3.05816952
37amyloid precursor protein catabolic process (GO:0042987)3.02670322
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02582375
39myelin maintenance (GO:0043217)2.96750155
40activated T cell proliferation (GO:0050798)2.95961300
41regulation of lipoprotein metabolic process (GO:0050746)2.95242891
42isoprenoid biosynthetic process (GO:0008299)2.91269000
43negative regulation of protein localization to cell surface (GO:2000009)2.91087123
44viral life cycle (GO:0019058)2.90822865
45ventricular cardiac muscle cell development (GO:0055015)2.88905174
46nucleobase-containing small molecule interconversion (GO:0015949)2.88664876
47regulation of T cell migration (GO:2000404)2.87860697
48response to lipoprotein particle (GO:0055094)2.86249118
49regulation of integrin-mediated signaling pathway (GO:2001044)2.85151428
50GDP-mannose metabolic process (GO:0019673)2.84905414
51muscle cell migration (GO:0014812)2.83065865
52sequestering of actin monomers (GO:0042989)2.82456776
53translation (GO:0006412)2.79493932
54regulation of cellular amino acid metabolic process (GO:0006521)2.78926186
55GPI anchor biosynthetic process (GO:0006506)2.78539213
56translational initiation (GO:0006413)2.78463741
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77997299
58regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.77883221
59protein neddylation (GO:0045116)2.76178595
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.76077738
61cellular protein complex disassembly (GO:0043624)2.74292382
62positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.73862711
63protein targeting to mitochondrion (GO:0006626)2.72082217
64extracellular fibril organization (GO:0043206)2.71341300
65positive regulation of oligodendrocyte differentiation (GO:0048714)2.68174754
66protein targeting to membrane (GO:0006612)2.66911063
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.66442980
68regulation of lymphocyte migration (GO:2000401)2.66145487
69regulation of mitochondrial translation (GO:0070129)2.65418736
70regulation of cholesterol esterification (GO:0010872)2.65299426
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.64261421
72negative regulation of ligase activity (GO:0051352)2.64261421
73regulation of apoptotic process involved in morphogenesis (GO:1902337)2.64211408
74negative regulation of chemokine production (GO:0032682)2.63473657
75formation of translation preinitiation complex (GO:0001731)2.60872309
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59536620
77positive regulation of interleukin-17 production (GO:0032740)2.58598442
78neutrophil activation (GO:0042119)2.58342821
79respiratory burst (GO:0045730)2.56087816
80monocyte chemotaxis (GO:0002548)2.55523927
81negative regulation of chondrocyte differentiation (GO:0032331)2.54776800
82creatine metabolic process (GO:0006600)2.52403810
83enteric nervous system development (GO:0048484)2.51485672
84regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.51359429
85nucleotide-sugar biosynthetic process (GO:0009226)2.50963169
86signal peptide processing (GO:0006465)2.50682857
87ribonucleoprotein complex biogenesis (GO:0022613)2.49271385
88amino acid import (GO:0043090)2.49160633
89establishment of protein localization to mitochondrion (GO:0072655)2.49011099
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.48060474
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.47979381
92establishment of integrated proviral latency (GO:0075713)2.47535182
93hemidesmosome assembly (GO:0031581)2.47215865
94peptidyl-proline hydroxylation (GO:0019511)2.47045754
95skin morphogenesis (GO:0043589)2.46249859
96L-amino acid import (GO:0043092)2.46231405
97cellular copper ion homeostasis (GO:0006878)2.45946786
98galactose catabolic process (GO:0019388)2.45450753
99granulocyte activation (GO:0036230)2.45325768
1004-hydroxyproline metabolic process (GO:0019471)2.45064569
101long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.44864660
102desmosome organization (GO:0002934)2.44640527
103response to interferon-beta (GO:0035456)2.44165973
104phagocytosis, engulfment (GO:0006911)2.44094894
105axon development (GO:0061564)2.42971494
106regulation of metalloenzyme activity (GO:0048552)2.42682021
107positive regulation of actin filament depolymerization (GO:0030836)2.42121557
108leukocyte aggregation (GO:0070486)2.41632420
109protein localization to mitochondrion (GO:0070585)2.41053945
110mitotic nuclear envelope reassembly (GO:0007084)2.40369027
111nuclear envelope reassembly (GO:0031468)2.40369027
112hydrogen peroxide catabolic process (GO:0042744)2.40363001
113negative regulation of neurotransmitter transport (GO:0051589)2.39761482
114branching involved in salivary gland morphogenesis (GO:0060445)2.39327970
115long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.38777186
116negative regulation of neurotransmitter secretion (GO:0046929)2.38507228
117regulation of collateral sprouting (GO:0048670)2.38398673
118DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.37900736
119GPI anchor metabolic process (GO:0006505)2.37686037
120T cell migration (GO:0072678)2.36995413
121endothelial cell morphogenesis (GO:0001886)2.36474853
122galactose metabolic process (GO:0006012)2.35924302
123regulation of T-helper 1 cell differentiation (GO:0045625)2.34996568
124response to redox state (GO:0051775)2.34474786
125protein heterotetramerization (GO:0051290)2.34394260
126T-helper 1 type immune response (GO:0042088)2.33619479
127establishment of viral latency (GO:0019043)2.33153472
128signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.32079012
129intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.32079012
130regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.31934259
131regulation of interleukin-17 production (GO:0032660)2.30306379
132fatty-acyl-CoA metabolic process (GO:0035337)2.29765418
133regulation of monocyte chemotaxis (GO:0090025)2.29544831
134tissue regeneration (GO:0042246)2.29431209
135signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.27658893
136signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.27658893
137signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.27658893
138positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.26957601
139transcription elongation from RNA polymerase III promoter (GO:0006385)2.25733586
140termination of RNA polymerase III transcription (GO:0006386)2.25733586
141mitochondrial calcium ion homeostasis (GO:0051560)2.24520333
142dermatan sulfate biosynthetic process (GO:0030208)2.24347420
143eosinophil chemotaxis (GO:0048245)2.24306700
144protein complex disassembly (GO:0043241)2.24080706
145signal transduction involved in DNA damage checkpoint (GO:0072422)2.23995824
146signal transduction involved in DNA integrity checkpoint (GO:0072401)2.23995824
147respiratory electron transport chain (GO:0022904)2.23961727
148positive regulation of glial cell differentiation (GO:0045687)2.23384509
149negative regulation of acute inflammatory response (GO:0002674)2.23246596
150leukocyte migration involved in inflammatory response (GO:0002523)2.23148405
151cellular component biogenesis (GO:0044085)2.23069120
152positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.22331890
153establishment of protein localization to membrane (GO:0090150)2.21488954
154positive regulation of gliogenesis (GO:0014015)2.21422131
155tricarboxylic acid cycle (GO:0006099)2.20840333
156negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.20821057
157electron transport chain (GO:0022900)2.20595426
158erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.20504023
159L-phenylalanine metabolic process (GO:0006558)2.20504023
160nucleotide transmembrane transport (GO:1901679)2.20481190
161positive regulation of T cell migration (GO:2000406)2.20428795
162positive regulation of lymphocyte migration (GO:2000403)2.20071640
163positive regulation of astrocyte differentiation (GO:0048711)2.19569642
164photoreceptor cell differentiation (GO:0046530)2.19423931
165eye photoreceptor cell differentiation (GO:0001754)2.19423931
166positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.18717115
167removal of superoxide radicals (GO:0019430)2.17862074
168cellular response to superoxide (GO:0071451)2.17862074
169cellular response to oxygen radical (GO:0071450)2.17862074
170astrocyte development (GO:0014002)2.17686380
171very long-chain fatty acid metabolic process (GO:0000038)2.17396890
172ribosomal small subunit biogenesis (GO:0042274)2.16157912
173oligodendrocyte differentiation (GO:0048709)2.15719973
174copper ion homeostasis (GO:0055070)2.15573507
175dermatan sulfate metabolic process (GO:0030205)2.15568069
176positive regulation of T-helper 1 type immune response (GO:0002827)2.15509532
177positive regulation of toll-like receptor signaling pathway (GO:0034123)2.14398443
178import into cell (GO:0098657)2.14188775
179positive regulation of alpha-beta T cell proliferation (GO:0046641)2.12448818
180detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.12302989
181detection of temperature stimulus involved in sensory perception (GO:0050961)2.12302989
182regulation of neuron projection regeneration (GO:0070570)2.11766973
183regulation of axon regeneration (GO:0048679)2.11766973
184* mast cell activation (GO:0045576)2.11685129
185negative regulation of myoblast differentiation (GO:0045662)2.10717603
186autophagic vacuole fusion (GO:0000046)2.10218646
187peptidyl-tyrosine autophosphorylation (GO:0038083)2.10100193
188ATP synthesis coupled proton transport (GO:0015986)2.09906980
189energy coupled proton transport, down electrochemical gradient (GO:0015985)2.09906980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.16058915
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.25874487
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.11096464
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.77731220
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.45379682
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.19027135
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90470518
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.78767741
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69728189
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69710162
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63229232
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.62905540
13* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39423005
14ZNF263_19887448_ChIP-Seq_K562_Human2.38199910
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.34492491
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28648342
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24025473
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15110825
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14857011
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.12651271
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07862064
22* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05118373
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00772641
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.00548808
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99099999
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97014512
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.95338234
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94832371
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93599507
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90544075
31* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88605056
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87494559
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86876901
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86143167
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82897470
36RUNX_20019798_ChIP-Seq_JUKART_Human1.82090051
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.81563677
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80083249
39SCL_19346495_ChIP-Seq_HPC-7_Human1.78282594
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77832436
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.77669571
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.77669571
43* XRN2_22483619_ChIP-Seq_HELA_Human1.76771758
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76363537
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.73871315
46AR_21909140_ChIP-Seq_LNCAP_Human1.73346993
47* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.71956836
48CLOCK_20551151_ChIP-Seq_293T_Human1.71889090
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.69642369
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69619420
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69146420
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68659887
53* DCP1A_22483619_ChIP-Seq_HELA_Human1.67356614
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.65491791
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64921308
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63040266
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61145628
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59518803
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57768790
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57709925
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56855700
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.56834997
63* RACK7_27058665_Chip-Seq_MCF-7_Human1.56630949
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.55827659
65* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55728472
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54887388
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54823491
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54255081
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53099216
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52869536
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50998034
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50706413
73AR_21572438_ChIP-Seq_LNCaP_Human1.49617056
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47918165
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47256174
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46666927
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46390141
78SOX2_20726797_ChIP-Seq_SW620_Human1.41754427
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38794365
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.37638052
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37410291
82ATF3_27146783_Chip-Seq_COLON_Human1.36993920
83VDR_24787735_ChIP-Seq_THP-1_Human1.36782478
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32973049
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.32185603
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.32141143
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31998731
88* GABP_19822575_ChIP-Seq_HepG2_Human1.31975359
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31492152
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30772174
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30292258
92EOMES_21245162_ChIP-Seq_HESCs_Human1.29799384
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28354907
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28143539
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27688345
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27520638
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26895432
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25833614
99* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25138639
100* TTF2_22483619_ChIP-Seq_HELA_Human1.23809321
101ELK1_22589737_ChIP-Seq_MCF10A_Human1.22959973
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21448650
103SOX17_20123909_ChIP-Seq_XEN_Mouse1.20722874
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.20187782
105EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19510610
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19372964
107* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19304875
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19188080
109OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18315116
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18131688
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18131688
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17447850
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16747123
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14603295
115* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13807302
116CJUN_26792858_Chip-Seq_BT549_Human1.13227540
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13049541
118STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12847861
119TBX5_21415370_ChIP-Seq_HL-1_Mouse1.11966532
120EGR1_19032775_ChIP-ChIP_M12_Human1.10810373
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10730277
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09310971
123TET1_21451524_ChIP-Seq_MESCs_Mouse1.09286581
124SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09174717
125* WT1_19549856_ChIP-ChIP_CCG9911_Human1.07378370
126P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06937467
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06767350
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06670611
129ESR2_21235772_ChIP-Seq_MCF-7_Human1.06652322
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06458810
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06386842
132ELK1_19687146_ChIP-ChIP_HELA_Human1.05305666
133MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04815111
134GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04390136
135TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03269031
136SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01439672
137KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01060149
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00339099
139CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99956119
140ER_23166858_ChIP-Seq_MCF-7_Human0.99859482
141TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98993140
142YY1_21170310_ChIP-Seq_MESCs_Mouse0.98094135
143NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97761112
144MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95994557
145SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93063917
146VDR_24763502_ChIP-Seq_THP-1_Human0.92587755
147ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91826379
148POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91426041
149ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91409676
150MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91150563
151UBF1/2_26484160_Chip-Seq_HMECs_Human0.91139626
152SPI1_23547873_ChIP-Seq_NB4_Human0.90645354
153VDR_22108803_ChIP-Seq_LS180_Human0.89787661
154JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88056725
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.86754751
156CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86738486
157* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86379596
158LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86266070
159ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84972149
160SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84877833
161STAT1_20625510_ChIP-Seq_HELA_Human0.83968458
162TP53_18474530_ChIP-ChIP_U2OS_Human0.83079582
163MYB_26560356_Chip-Seq_TH2_Human0.82179400
164EED_16625203_ChIP-ChIP_MESCs_Mouse0.81837268
165CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81806262
166KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81537080
167KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81537080
168KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81537080
169GATA1_19941826_ChIP-Seq_K562_Human0.81110077
170SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.80867734
171THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80789283
172FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.80728351
173SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.80483792
174CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79767700
175* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79561662
176PU_27001747_Chip-Seq_BMDM_Mouse0.79002737
177MTF2_20144788_ChIP-Seq_MESCs_Mouse0.76383726
178GATA3_26560356_Chip-Seq_TH2_Human0.75809124
179EP300_21415370_ChIP-Seq_HL-1_Mouse0.75508675
180SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75495765
181RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74969426
182PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74441961
183GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74239105
184SOX2_19829295_ChIP-Seq_ESCs_Human0.74157498
185NANOG_19829295_ChIP-Seq_ESCs_Human0.74157498
186PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73447211
187TAL1_26923725_Chip-Seq_HPCs_Mouse0.72867456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.19570133
2MP0000920_abnormal_myelination3.80091233
3MP0003724_increased_susceptibility_to3.51176338
4MP0002148_abnormal_hypersensitivity_rea3.00127726
5MP0003705_abnormal_hypodermis_morpholog2.89529233
6MP0003136_yellow_coat_color2.87066320
7MP0006082_CNS_inflammation2.67124719
8MP0001835_abnormal_antigen_presentation2.62701233
9MP0009785_altered_susceptibility_to2.62080365
10MP0005257_abnormal_intraocular_pressure2.48770702
11MP0003690_abnormal_glial_cell2.34181709
12MP0003950_abnormal_plasma_membrane2.29728119
13MP0009780_abnormal_chondrocyte_physiolo2.28607328
14MP0003941_abnormal_skin_development2.28316167
15MP0005000_abnormal_immune_tolerance2.27980831
16MP0005275_abnormal_skin_tensile2.26979212
17MP0005503_abnormal_tendon_morphology2.25809007
18MP0005671_abnormal_response_to2.20724370
19MP0003191_abnormal_cellular_cholesterol2.20516890
20MP0002419_abnormal_innate_immunity2.11092840
21MP0005025_abnormal_response_to2.04988249
22MP0005171_absent_coat_pigmentation2.03841904
23MP0005409_darkened_coat_color2.00854297
24MP0003566_abnormal_cell_adhesion1.99422449
25MP0000685_abnormal_immune_system1.99282993
26MP0000372_irregular_coat_pigmentation1.96190920
27MP0004381_abnormal_hair_follicle1.91442528
28MP0009379_abnormal_foot_pigmentation1.87664643
29MP0005387_immune_system_phenotype1.87604485
30MP0001790_abnormal_immune_system1.87604485
31MP0003186_abnormal_redox_activity1.85879956
32MP0000751_myopathy1.77609196
33MP0008438_abnormal_cutaneous_collagen1.75869506
34MP0005167_abnormal_blood-brain_barrier1.72514630
35MP0004742_abnormal_vestibular_system1.70612292
36MP0000762_abnormal_tongue_morphology1.69430403
37MP0003436_decreased_susceptibility_to1.67546795
38MP0002723_abnormal_immune_serum1.66626042
39MP0001905_abnormal_dopamine_level1.65916740
40MP0002009_preneoplasia1.64565546
41MP0002060_abnormal_skin_morphology1.64554666
42MP0001299_abnormal_eye_distance/1.63422398
43MP0005023_abnormal_wound_healing1.57228255
44MP0002452_abnormal_antigen_presenting1.57107927
45MP0010368_abnormal_lymphatic_system1.54062424
46MP0000343_altered_response_to1.51957044
47MP0002295_abnormal_pulmonary_circulatio1.51896295
48MP0005408_hypopigmentation1.48039086
49MP0002405_respiratory_system_inflammati1.47598135
50MP0009053_abnormal_anal_canal1.47439957
51MP0002420_abnormal_adaptive_immunity1.47154321
52MP0000750_abnormal_muscle_regeneration1.46518666
53MP0002166_altered_tumor_susceptibility1.46412582
54MP0001800_abnormal_humoral_immune1.46111407
55MP0001819_abnormal_immune_cell1.44902057
56MP0001851_eye_inflammation1.43320327
57MP0005670_abnormal_white_adipose1.43136326
58MP0002933_joint_inflammation1.42224855
59MP0001533_abnormal_skeleton_physiology1.40478550
60MP0000537_abnormal_urethra_morphology1.40395338
61MP0005164_abnormal_response_to1.40378161
62MP0005058_abnormal_lysosome_morphology1.39629924
63MP0001879_abnormal_lymphatic_vessel1.39425582
64MP0002006_tumorigenesis1.37029251
65MP0002796_impaired_skin_barrier1.36259078
66MP0005464_abnormal_platelet_physiology1.33183947
67MP0005508_abnormal_skeleton_morphology1.30500314
68MP0002877_abnormal_melanocyte_morpholog1.29686984
69MP0003123_paternal_imprinting1.28702639
70MP0004233_abnormal_muscle_weight1.26280019
71MP0005501_abnormal_skin_physiology1.25982328
72MP0003279_aneurysm1.24204139
73MP0003942_abnormal_urinary_system1.21395632
74MP0003172_abnormal_lysosome_physiology1.17977687
75MP0004957_abnormal_blastocyst_morpholog1.17104259
76MP0003634_abnormal_glial_cell1.16976098
77MP0004858_abnormal_nervous_system1.16212415
78MP0005165_increased_susceptibility_to1.15520028
79MP0001853_heart_inflammation1.14495609
80MP0003011_delayed_dark_adaptation1.13325620
81MP0009764_decreased_sensitivity_to1.13082912
82MP0005330_cardiomyopathy1.11677935
83MP0002998_abnormal_bone_remodeling1.11079460
84MP0001243_abnormal_dermal_layer1.11000866
85MP0009333_abnormal_splenocyte_physiolog1.10891601
86MP0000465_gastrointestinal_hemorrhage1.10413133
87MP0001542_abnormal_bone_strength1.09858644
88MP0003385_abnormal_body_wall1.07912296
89MP0003763_abnormal_thymus_physiology1.07497853
90MP0009250_abnormal_appendicular_skeleto1.07453683
91MP0003633_abnormal_nervous_system1.05242800
92MP0003075_altered_response_to1.05000679
93MP0002938_white_spotting1.04329299
94MP0008932_abnormal_embryonic_tissue1.04019781
95MP0001958_emphysema1.03935760
96MP0004134_abnormal_chest_morphology1.02797228
97MP0000534_abnormal_ureter_morphology1.02680742
98MP0003329_amyloid_beta_deposits1.02212902
99MP0000647_abnormal_sebaceous_gland1.02083656
100MP0004272_abnormal_basement_membrane1.01821707
101MP0002108_abnormal_muscle_morphology1.00671913
102MP0001986_abnormal_taste_sensitivity1.00453754
103MP0000249_abnormal_blood_vessel0.99609618
104MP0000604_amyloidosis0.98618890
105MP0000467_abnormal_esophagus_morphology0.97229846
106MP0006054_spinal_hemorrhage0.96630701
107MP0008469_abnormal_protein_level0.96525926
108MP0001845_abnormal_inflammatory_respons0.96435724
109MP0010771_integument_phenotype0.96279265
110MP0005197_abnormal_uvea_morphology0.95944233
111MP0003315_abnormal_perineum_morphology0.95690021
112MP0001849_ear_inflammation0.95652279
113MP0004510_myositis0.95433722
114MP0009384_cardiac_valve_regurgitation0.94567025
115MP0003806_abnormal_nucleotide_metabolis0.94496697
116MP0004883_abnormal_blood_vessel0.91984646
117MP0002697_abnormal_eye_size0.91865053
118MP0005310_abnormal_salivary_gland0.91788647
119MP0009840_abnormal_foam_cell0.91463526
120MP0000716_abnormal_immune_system0.89640615
121MP0000733_abnormal_muscle_development0.89557666
122MP0010155_abnormal_intestine_physiology0.89179787
123MP0003448_altered_tumor_morphology0.88933791
124MP0001881_abnormal_mammary_gland0.87228676
125MP0008260_abnormal_autophagy0.87063425
126MP0000749_muscle_degeneration0.86872429
127MP0000767_abnormal_smooth_muscle0.86450050
128MP0002163_abnormal_gland_morphology0.85595740
129MP0004142_abnormal_muscle_tone0.85075503
130MP0002132_abnormal_respiratory_system0.84314287
131MP0009697_abnormal_copulation0.83977170
132MP0002254_reproductive_system_inflammat0.82703910
133MP0003828_pulmonary_edema0.82480865
134MP0004782_abnormal_surfactant_physiolog0.82247360
135MP0003631_nervous_system_phenotype0.80757021
136MP0005360_urolithiasis0.80624544
137MP0004147_increased_porphyrin_level0.80087886
138MP0002896_abnormal_bone_mineralization0.79788304
139MP0002233_abnormal_nose_morphology0.79781931
140MP0003786_premature_aging0.79021690
141MP0000579_abnormal_nail_morphology0.78521276
142MP0005623_abnormal_meninges_morphology0.77686662
143MP0000759_abnormal_skeletal_muscle0.77192074
144MP0000163_abnormal_cartilage_morphology0.77130612
145MP0000358_abnormal_cell_content/0.76795153
146MP0003656_abnormal_erythrocyte_physiolo0.76361226
147MP0003755_abnormal_palate_morphology0.76020726
148MP0000627_abnormal_mammary_gland0.75778595
149MP0005083_abnormal_biliary_tract0.75472564
150MP0005410_abnormal_fertilization0.75465019
151MP0000383_abnormal_hair_follicle0.75298723
152MP0002282_abnormal_trachea_morphology0.75261541
153MP0004264_abnormal_extraembryonic_tissu0.74826542
154MP0001346_abnormal_lacrimal_gland0.74301473
155MP0009765_abnormal_xenobiotic_induced0.74300088
156MP0009763_increased_sensitivity_to0.74171980
157MP0004947_skin_inflammation0.73775758
158MP0004019_abnormal_vitamin_homeostasis0.73592039
159MP0005193_abnormal_anterior_eye0.73401778
160MP0003195_calcinosis0.72429044
161MP0010678_abnormal_skin_adnexa0.72247565
162MP0002090_abnormal_vision0.72137408
163MP0000747_muscle_weakness0.71971846
164MP0002932_abnormal_joint_morphology0.71678090
165MP0005379_endocrine/exocrine_gland_phen0.69992024
166MP0003937_abnormal_limbs/digits/tail_de0.69327723
167MP0001293_anophthalmia0.69244793
168MP0006138_congestive_heart_failure0.68498836
169MP0000462_abnormal_digestive_system0.67273947
170MP0000049_abnormal_middle_ear0.67216379
171MP0006036_abnormal_mitochondrial_physio0.66792141
172MP0002876_abnormal_thyroid_physiology0.66291670
173MP0001216_abnormal_epidermal_layer0.64773794
174MP0002085_abnormal_embryonic_tissue0.62966516
175MP0002972_abnormal_cardiac_muscle0.61701357
176MP0004087_abnormal_muscle_fiber0.61176419
177MP0003936_abnormal_reproductive_system0.59956396

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.07386394
2Parakeratosis (HP:0001036)4.44236052
3Protrusio acetabuli (HP:0003179)4.15591197
4Neurofibrillary tangles (HP:0002185)3.94211828
5Axonal loss (HP:0003447)3.75341624
6Recurrent abscess formation (HP:0002722)3.63778047
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.55701307
8Renal Fanconi syndrome (HP:0001994)3.39389002
9Elevated erythrocyte sedimentation rate (HP:0003565)3.36283861
10Eczematoid dermatitis (HP:0000976)3.33478696
11Segmental peripheral demyelination/remyelination (HP:0003481)3.27090301
12Peripheral hypomyelination (HP:0007182)3.27043988
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.25713031
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.25713031
15Recurrent bacterial skin infections (HP:0005406)3.24839710
16Stomatitis (HP:0010280)3.17380114
17Distal lower limb muscle weakness (HP:0009053)3.11513917
18Abnormality of macrophages (HP:0004311)3.11031388
19Vacuolated lymphocytes (HP:0001922)3.07555457
20Vertebral compression fractures (HP:0002953)3.01006526
21Increased hepatocellular lipid droplets (HP:0006565)2.87464460
22Cerebral hemorrhage (HP:0001342)2.86716356
23Atrophic scars (HP:0001075)2.82090262
24Hepatosplenomegaly (HP:0001433)2.79141670
25Acute necrotizing encephalopathy (HP:0006965)2.77111682
26Patchy hypopigmentation of hair (HP:0011365)2.76362901
27Abnormality of the umbilical cord (HP:0010881)2.74658676
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.73822811
29Cervical subluxation (HP:0003308)2.65796929
30Recurrent skin infections (HP:0001581)2.65399088
31Lipid accumulation in hepatocytes (HP:0006561)2.63284860
32Congenital ichthyosiform erythroderma (HP:0007431)2.63159904
33Mitochondrial inheritance (HP:0001427)2.61345341
34Short nail (HP:0001799)2.57275285
35Purpura (HP:0000979)2.56306168
36Hypoalphalipoproteinemia (HP:0003233)2.54990826
37White forelock (HP:0002211)2.52025393
38Retinal dysplasia (HP:0007973)2.51172042
39Sparse eyelashes (HP:0000653)2.49858061
40Ankle contracture (HP:0006466)2.44923176
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44850552
42Spinal rigidity (HP:0003306)2.44682940
43Reduced subcutaneous adipose tissue (HP:0003758)2.43367991
44Autoimmune hemolytic anemia (HP:0001890)2.43263192
45Obstructive lung disease (HP:0006536)2.42610549
46Chronic obstructive pulmonary disease (HP:0006510)2.42610549
47Exertional dyspnea (HP:0002875)2.42377685
48Onion bulb formation (HP:0003383)2.42284839
49Follicular hyperkeratosis (HP:0007502)2.40631727
50Abnormalities of placenta or umbilical cord (HP:0001194)2.40407985
51Fragile skin (HP:0001030)2.40395508
52Abnormality of the distal phalanges of the toes (HP:0010182)2.38219249
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37002426
54Abnormality of the axillary hair (HP:0100134)2.36727731
55Abnormality of secondary sexual hair (HP:0009888)2.36727731
56Abnormality of dentin (HP:0010299)2.35854375
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.35164881
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.35164881
59Trismus (HP:0000211)2.34627238
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.34528468
61Osteolytic defects of the hand bones (HP:0009699)2.34528468
62Spontaneous hematomas (HP:0007420)2.34452018
63Cardiovascular calcification (HP:0011915)2.31296299
64Prolonged neonatal jaundice (HP:0006579)2.31124309
65Acute encephalopathy (HP:0006846)2.29339354
66Vascular tortuosity (HP:0004948)2.28733190
67Abnormal mitochondria in muscle tissue (HP:0008316)2.27093069
68Petechiae (HP:0000967)2.26890738
69Abnormality of glycolysis (HP:0004366)2.26271220
70Increased serum pyruvate (HP:0003542)2.26271220
71Soft skin (HP:0000977)2.25971775
72Increased IgM level (HP:0003496)2.25179607
73Leukodystrophy (HP:0002415)2.25099602
74Hypothermia (HP:0002045)2.23465113
75Generalized amyotrophy (HP:0003700)2.22722429
76Myositis (HP:0100614)2.22086332
77Abnormality of the fetal cardiovascular system (HP:0010948)2.19972826
78Abnormal umbilical cord blood vessels (HP:0011403)2.19972826
79Single umbilical artery (HP:0001195)2.19972826
80Rough bone trabeculation (HP:0100670)2.19112582
81Progressive macrocephaly (HP:0004481)2.18852139
823-Methylglutaconic aciduria (HP:0003535)2.18762775
83Abnormality of renal resorption (HP:0011038)2.18209900
84Hypoplasia of the iris (HP:0007676)2.16067221
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14789528
86Sensory axonal neuropathy (HP:0003390)2.14638590
87Pulmonary artery stenosis (HP:0004415)2.13010840
88Aortic dissection (HP:0002647)2.12271423
89Cerebral edema (HP:0002181)2.11956160
90Increased intramyocellular lipid droplets (HP:0012240)2.11793772
91Abnormal delivery (HP:0001787)2.11049982
92Vascular calcification (HP:0004934)2.10773897
93Hepatocellular necrosis (HP:0001404)2.09857272
94Slow saccadic eye movements (HP:0000514)2.09384908
95Arterial tortuosity (HP:0005116)2.09079448
96Glucose intolerance (HP:0000833)2.06051739
97Abnormality of cells of the erythroid lineage (HP:0012130)2.03129529
98Vasculitis (HP:0002633)2.02824735
99Cerebral inclusion bodies (HP:0100314)2.02713788
100Concave nail (HP:0001598)2.02695571
101Spinal cord compression (HP:0002176)2.02503809
102Elbow flexion contracture (HP:0002987)2.02464908
103Hepatic necrosis (HP:0002605)2.02248587
104Partial duplication of thumb phalanx (HP:0009944)2.00958598
105Premature skin wrinkling (HP:0100678)2.00650644
106Hypergammaglobulinemia (HP:0010702)2.00393734
107Abnormality of placental membranes (HP:0011409)1.99044413
108Amniotic constriction ring (HP:0009775)1.99044413
109Amyloidosis (HP:0011034)1.98805764
110Increased muscle lipid content (HP:0009058)1.97619446
111Metaphyseal dysplasia (HP:0100255)1.97565278
112Chronic otitis media (HP:0000389)1.97069908
113Recurrent gram-negative bacterial infections (HP:0005420)1.96107061
114Popliteal pterygium (HP:0009756)1.95973624
115Pterygium (HP:0001059)1.95870601
116Mildly elevated creatine phosphokinase (HP:0008180)1.93987452
117Exercise intolerance (HP:0003546)1.92846767
118Macrocytic anemia (HP:0001972)1.92686204
119Abnormality of T cell number (HP:0011839)1.91587634
120Abnormal hemoglobin (HP:0011902)1.91283784
121Ulnar claw (HP:0001178)1.91148836
122Increased neuronal autofluorescent lipopigment (HP:0002074)1.90839620
123Retrobulbar optic neuritis (HP:0100654)1.90156285
124Optic neuritis (HP:0100653)1.90156285
125Abnormality of the corticospinal tract (HP:0002492)1.89717514
126Aortic aneurysm (HP:0004942)1.88507387
127Achilles tendon contracture (HP:0001771)1.88277782
128Type 1 muscle fiber predominance (HP:0003803)1.87751618
129Abnormality of the phalanges of the 2nd finger (HP:0009541)1.87260629
130Autoamputation (HP:0001218)1.84525403
131Bell-shaped thorax (HP:0001591)1.84367731
132Stridor (HP:0010307)1.83910346
133Entropion (HP:0000621)1.83876784
134Reticulocytopenia (HP:0001896)1.82975312
135Shallow orbits (HP:0000586)1.82687009
136Bladder diverticulum (HP:0000015)1.82305041
137Increased connective tissue (HP:0009025)1.81957156
138Distal upper limb amyotrophy (HP:0007149)1.81520882
139Upper limb amyotrophy (HP:0009129)1.81520882
140Orchitis (HP:0100796)1.81360166
141Microglossia (HP:0000171)1.81098892
142Wormian bones (HP:0002645)1.80517685
143Respiratory failure (HP:0002878)1.80457376
144Increased CSF lactate (HP:0002490)1.80207042
145Redundant skin (HP:0001582)1.79827378
146Spastic paraparesis (HP:0002313)1.79246419
147Type I transferrin isoform profile (HP:0003642)1.79047734
148Blue sclerae (HP:0000592)1.78881252
149Paralysis (HP:0003470)1.78772392
150Thick nail (HP:0001805)1.78740418
151Aplasia of the musculature (HP:0100854)1.76569096
152Anhidrosis (HP:0000970)1.76260023
153Hypolipoproteinemia (HP:0010981)1.76118701
154Abnormality of carpal bone ossification (HP:0006257)1.75936421
155Gastrointestinal stroma tumor (HP:0100723)1.75616659
156Abnormality of the Achilles tendon (HP:0005109)1.75021959
157Hypokalemic alkalosis (HP:0001949)1.73225993
158Facial cleft (HP:0002006)1.72628794
159Delayed cranial suture closure (HP:0000270)1.71483446
160Right ventricular cardiomyopathy (HP:0011663)1.71120143
161Testicular atrophy (HP:0000029)1.70760010
162Loss of speech (HP:0002371)1.70726267
163Peripheral demyelination (HP:0011096)1.70363009
164Partial duplication of the phalanx of hand (HP:0009999)1.70137115
165Dysostosis multiplex (HP:0000943)1.69914874
166Supranuclear gaze palsy (HP:0000605)1.69892103
167Recurrent pneumonia (HP:0006532)1.69149509
168Urticaria (HP:0001025)1.68318571
169Adrenal hypoplasia (HP:0000835)1.67699434
170Down-sloping shoulders (HP:0200021)1.67677999
171Systemic lupus erythematosus (HP:0002725)1.67224144
172Abnormal number of erythroid precursors (HP:0012131)1.66628629
173Hand muscle atrophy (HP:0009130)1.66359673
174Mediastinal lymphadenopathy (HP:0100721)1.66346722
175Renal tubular dysfunction (HP:0000124)1.65994085
176Ulnar bowing (HP:0003031)1.65945076
177Natal tooth (HP:0000695)1.65435237
178Fragile nails (HP:0001808)1.62162091
179Lactic acidosis (HP:0003128)1.60810888
180Acanthosis nigricans (HP:0000956)1.58381520
181Short clavicles (HP:0000894)1.57988989
182Hypoplastic left heart (HP:0004383)1.57575873
183Neonatal short-limb short stature (HP:0008921)1.56624450
184Abnormality of aromatic amino acid family metabolism (HP:0004338)1.54975693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.93287379
2EPHA23.81460323
3PBK3.58723473
4STK393.40148024
5EPHB13.24205893
6VRK22.92326254
7PDK22.87012391
8MAPKAPK52.86600647
9MAP3K122.70067758
10TESK22.62922049
11STK162.42019224
12PAK42.40911881
13BLK2.22828169
14NME22.19107667
15BUB12.09509507
16KDR1.94157788
17TXK1.93704141
18EPHB21.92471608
19PTK21.85167458
20OXSR11.83388241
21LIMK11.81757591
22MAP3K141.80751022
23NEK11.75179460
24GRK71.74270308
25FES1.73448888
26IRAK41.70467543
27MUSK1.63657837
28LATS21.63350283
29PKN11.58683506
30TIE11.57073564
31TBK11.50897270
32MAP4K11.49558026
33ADRBK21.48552369
34IKBKE1.44193118
35PIM21.36491331
36CLK11.35766364
37CSK1.34022359
38IKBKB1.32703898
39MAPKAPK31.31385704
40KIT1.21946474
41MYLK1.21247540
42TEC1.19756202
43CASK1.18701547
44ERBB41.18435312
45IRAK11.18063033
46NME11.17139945
47TRPM71.12563851
48MAPK151.11261926
49EIF2AK11.10726842
50DAPK31.09286705
51TRIB31.09147415
52TNIK1.08055707
53FGR1.07742243
54LCK1.07335194
55BTK1.04582845
56GRK11.04479056
57BCR1.04357396
58NTRK11.04126280
59MAP3K31.03709406
60PRKCQ1.02943039
61BRAF1.01541437
62PDGFRA1.01477576
63BMPR1B0.99475319
64JAK30.98827626
65LRRK20.98410468
66SIK10.97596523
67PRKG20.97274367
68NLK0.95392040
69BCKDK0.93565003
70RPS6KB20.93364449
71MATK0.90656480
72MET0.89906341
73TYK20.89757485
74MAP2K20.87030009
75PAK20.86385465
76CDK80.85846016
77MOS0.84685853
78WEE10.83856152
79BMPR20.83716992
80LYN0.81521531
81TESK10.81124161
82GRK50.80697138
83PHKG20.79852203
84PHKG10.79852203
85TYRO30.79483728
86ROCK20.79366374
87WNK40.79059470
88ITK0.78944540
89ZAP700.77082527
90CAMK2G0.76121161
91RPS6KA50.76074945
92BRSK10.75545591
93CSF1R0.73735379
94PRKCE0.73485568
95PAK10.73294905
96IRAK20.73209052
97PRKCI0.72876693
98SYK0.72453289
99FLT30.70510847
100NEK60.69857972
101DMPK0.69422720
102TGFBR20.68902793
103EPHA30.67493231
104ABL20.67257952
105DAPK10.65895130
106PRKD10.65417128
107AURKA0.64448399
108PDGFRB0.63689067
109TTN0.62611387
110PIK3CA0.61996788
111SCYL20.61343310
112AURKB0.61304832
113NUAK10.60266984
114HCK0.60150937
115SRPK10.59788097
116TTK0.59031824
117DDR20.57735608
118JAK10.57523407
119TRIM280.56496940
120DYRK20.54584126
121ILK0.54063743
122AKT20.53733087
123ADRBK10.53706608
124STK100.53171241
125INSR0.52856171
126SIK30.51711277
127PRKD30.50905354
128GSK3A0.50813755
129ROCK10.49582380
130PRKCD0.48546170
131MST1R0.47976098
132CDK70.47964417
133WNK10.47817017
134FYN0.47685011
135PLK10.46915316
136TLK10.45298142
137IRAK30.45150955
138MAP2K10.44907239
139VRK10.44581644
140LMTK20.44136184
141IGF1R0.44048130
142CAMK2D0.43668768
143MAPKAPK20.43361539
144STK40.43223422
145YES10.43146541
146SMG10.42725152
147ARAF0.42598541
148ABL10.42189705
149MAPK40.42082324
150CSNK1G30.41261937
151PKN20.40680684
152MAPK120.40260994
153PLK30.38037068
154BMX0.37978146
155STK380.33450933
156MAP3K80.33421552
157PTK60.32679981
158EIF2AK30.32307904
159CAMK2B0.30270852
160PTK2B0.30068803
161ERN10.29919549
162TAOK20.29508107
163CDK180.29436882
164CSNK2A20.28229026
165CDK11A0.28139818
166FER0.27973091
167PAK60.27505693
168FGFR10.27111996
169CSNK2A10.25817234

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.68737353
2Fatty acid elongation_Homo sapiens_hsa000623.55282693
3Steroid biosynthesis_Homo sapiens_hsa001003.43440362
4Graft-versus-host disease_Homo sapiens_hsa053322.80178427
5Oxidative phosphorylation_Homo sapiens_hsa001902.66992980
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.46557067
7Ether lipid metabolism_Homo sapiens_hsa005652.32518916
8Protein export_Homo sapiens_hsa030602.27389547
9Allograft rejection_Homo sapiens_hsa053302.18536551
10Sulfur relay system_Homo sapiens_hsa041222.12299109
11Parkinsons disease_Homo sapiens_hsa050122.05676813
12Ribosome_Homo sapiens_hsa030102.04132773
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95207305
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86408863
15RNA polymerase_Homo sapiens_hsa030201.82063314
16Histidine metabolism_Homo sapiens_hsa003401.80724185
17Rheumatoid arthritis_Homo sapiens_hsa053231.76683521
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73293564
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72937743
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72654535
21Sphingolipid metabolism_Homo sapiens_hsa006001.72249277
22Malaria_Homo sapiens_hsa051441.68688120
23Alzheimers disease_Homo sapiens_hsa050101.68286495
24Sulfur metabolism_Homo sapiens_hsa009201.68228993
25Pyruvate metabolism_Homo sapiens_hsa006201.66440869
26Autoimmune thyroid disease_Homo sapiens_hsa053201.63338670
27Galactose metabolism_Homo sapiens_hsa000521.61637619
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55801997
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53389956
30Asthma_Homo sapiens_hsa053101.51319553
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.44072642
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.38103770
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37887558
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37307162
35Pyrimidine metabolism_Homo sapiens_hsa002401.36785920
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36215088
37Vibrio cholerae infection_Homo sapiens_hsa051101.35613914
38Leishmaniasis_Homo sapiens_hsa051401.35260199
39Biosynthesis of amino acids_Homo sapiens_hsa012301.35227187
40Other glycan degradation_Homo sapiens_hsa005111.34027405
41Carbon metabolism_Homo sapiens_hsa012001.32698477
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28889046
43DNA replication_Homo sapiens_hsa030301.28827967
44Primary immunodeficiency_Homo sapiens_hsa053401.27292792
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26931622
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25576399
47Hematopoietic cell lineage_Homo sapiens_hsa046401.24172066
48Pentose phosphate pathway_Homo sapiens_hsa000301.18947566
49Nucleotide excision repair_Homo sapiens_hsa034201.18537499
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14330282
51Staphylococcus aureus infection_Homo sapiens_hsa051501.13806162
52Fructose and mannose metabolism_Homo sapiens_hsa000511.12944472
53N-Glycan biosynthesis_Homo sapiens_hsa005101.12737842
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12087826
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10885245
56Mismatch repair_Homo sapiens_hsa034301.10163646
57Phagosome_Homo sapiens_hsa041451.09626669
58Pertussis_Homo sapiens_hsa051331.09267009
59Linoleic acid metabolism_Homo sapiens_hsa005911.07505659
60Salmonella infection_Homo sapiens_hsa051321.07484067
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05718636
62Arachidonic acid metabolism_Homo sapiens_hsa005901.05581229
63Huntingtons disease_Homo sapiens_hsa050161.04423277
64Phenylalanine metabolism_Homo sapiens_hsa003601.03591112
65NF-kappa B signaling pathway_Homo sapiens_hsa040641.03147607
66African trypanosomiasis_Homo sapiens_hsa051430.99738038
67Lysosome_Homo sapiens_hsa041420.97490128
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96216017
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91617702
70Base excision repair_Homo sapiens_hsa034100.90326862
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89335794
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89110795
73Osteoclast differentiation_Homo sapiens_hsa043800.88041535
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.85738414
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.85691115
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85385018
77Hippo signaling pathway_Homo sapiens_hsa043900.85363273
78Tight junction_Homo sapiens_hsa045300.83456735
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.82826513
80beta-Alanine metabolism_Homo sapiens_hsa004100.82178024
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81988492
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81522228
83Measles_Homo sapiens_hsa051620.81168132
84Basal cell carcinoma_Homo sapiens_hsa052170.81163164
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.81161003
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81022798
87Glutathione metabolism_Homo sapiens_hsa004800.79301838
88Viral myocarditis_Homo sapiens_hsa054160.79166545
89Focal adhesion_Homo sapiens_hsa045100.78616145
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78126363
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78087094
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77910687
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77728924
94Chemical carcinogenesis_Homo sapiens_hsa052040.77417610
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76790801
96Proteasome_Homo sapiens_hsa030500.75736130
97Chemokine signaling pathway_Homo sapiens_hsa040620.74617070
98Purine metabolism_Homo sapiens_hsa002300.70762306
99Vitamin digestion and absorption_Homo sapiens_hsa049770.70541551
100TGF-beta signaling pathway_Homo sapiens_hsa043500.70465091
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69269818
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.68677640
103Peroxisome_Homo sapiens_hsa041460.68188524
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66905946
105Platelet activation_Homo sapiens_hsa046110.65978623
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65391594
107Fat digestion and absorption_Homo sapiens_hsa049750.65107173
108Proteoglycans in cancer_Homo sapiens_hsa052050.64640168
109Thyroid cancer_Homo sapiens_hsa052160.64595501
110Arginine and proline metabolism_Homo sapiens_hsa003300.63939128
111Mineral absorption_Homo sapiens_hsa049780.62177967
112Hedgehog signaling pathway_Homo sapiens_hsa043400.61169056
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60879767
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60860925
115PPAR signaling pathway_Homo sapiens_hsa033200.60692903
116Fatty acid degradation_Homo sapiens_hsa000710.59850555
117Homologous recombination_Homo sapiens_hsa034400.59416775
118Vitamin B6 metabolism_Homo sapiens_hsa007500.59159715
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.58512839
120Shigellosis_Homo sapiens_hsa051310.58407403
121ECM-receptor interaction_Homo sapiens_hsa045120.58252959
122Arginine biosynthesis_Homo sapiens_hsa002200.58146427
123Prion diseases_Homo sapiens_hsa050200.56968959
124Tyrosine metabolism_Homo sapiens_hsa003500.54772480
125T cell receptor signaling pathway_Homo sapiens_hsa046600.54644709
126Fatty acid metabolism_Homo sapiens_hsa012120.54498746
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54262462
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.53926513
129Spliceosome_Homo sapiens_hsa030400.53854001
130One carbon pool by folate_Homo sapiens_hsa006700.53522387
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53291467
132RNA transport_Homo sapiens_hsa030130.53195523
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53045703
134Folate biosynthesis_Homo sapiens_hsa007900.52844149
135p53 signaling pathway_Homo sapiens_hsa041150.52090861
136Collecting duct acid secretion_Homo sapiens_hsa049660.51820638
137Cardiac muscle contraction_Homo sapiens_hsa042600.50670707
138Adherens junction_Homo sapiens_hsa045200.49645305
139Dilated cardiomyopathy_Homo sapiens_hsa054140.49438339
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48640057
141B cell receptor signaling pathway_Homo sapiens_hsa046620.47898780
142Protein digestion and absorption_Homo sapiens_hsa049740.47859995
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47670577
144Type I diabetes mellitus_Homo sapiens_hsa049400.47656308
145Tuberculosis_Homo sapiens_hsa051520.46081830
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.45406073
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.45350410
148Toxoplasmosis_Homo sapiens_hsa051450.43238183
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.42323395
150Legionellosis_Homo sapiens_hsa051340.39859534
151Basal transcription factors_Homo sapiens_hsa030220.39412499
152Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38584032
153Retinol metabolism_Homo sapiens_hsa008300.38333027
154Small cell lung cancer_Homo sapiens_hsa052220.38324557
155Bladder cancer_Homo sapiens_hsa052190.38311486
156Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36982699
157Propanoate metabolism_Homo sapiens_hsa006400.35502474
158Metabolic pathways_Homo sapiens_hsa011000.34899099
159TNF signaling pathway_Homo sapiens_hsa046680.34425833
160Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34286737
161Serotonergic synapse_Homo sapiens_hsa047260.33930020
162Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32661790
163Caffeine metabolism_Homo sapiens_hsa002320.30186437
164Ras signaling pathway_Homo sapiens_hsa040140.30102471

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