S100A16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.67904247
2central nervous system myelination (GO:0022010)7.67904247
3fatty acid elongation (GO:0030497)5.60951808
4Golgi transport vesicle coating (GO:0048200)5.46147522
5COPI coating of Golgi vesicle (GO:0048205)5.46147522
6myelin maintenance (GO:0043217)4.60976813
7protein maturation by protein folding (GO:0022417)4.59299580
8desmosome organization (GO:0002934)4.50902794
9hemidesmosome assembly (GO:0031581)4.49032130
10axon ensheathment (GO:0008366)4.30626249
11ensheathment of neurons (GO:0007272)4.30626249
12myelination (GO:0042552)4.28637799
13cell adhesion mediated by integrin (GO:0033627)4.26531211
14long-chain fatty acid biosynthetic process (GO:0042759)4.12273680
15regulation of metalloenzyme activity (GO:0048552)4.10127795
16cell-substrate junction assembly (GO:0007044)3.99812314
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.94049357
18protein retention in ER lumen (GO:0006621)3.91800749
19virion attachment to host cell (GO:0019062)3.83827487
20adhesion of symbiont to host cell (GO:0044650)3.83827487
21negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.82284540
22regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.79139985
23negative regulation of protein localization to cell surface (GO:2000009)3.72732682
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.71979555
25molting cycle (GO:0042303)3.70210684
26hair cycle (GO:0042633)3.70210684
27keratinization (GO:0031424)3.69666937
28creatine metabolic process (GO:0006600)3.62687691
29type B pancreatic cell proliferation (GO:0044342)3.46251032
30oligodendrocyte differentiation (GO:0048709)3.40727108
31keratinocyte proliferation (GO:0043616)3.40555804
32muscle cell migration (GO:0014812)3.39159948
33mitotic nuclear envelope reassembly (GO:0007084)3.39113145
34nuclear envelope reassembly (GO:0031468)3.39113145
35negative regulation of keratinocyte proliferation (GO:0010839)3.34903353
36cellular copper ion homeostasis (GO:0006878)3.31533702
37negative regulation of chondrocyte differentiation (GO:0032331)3.31416517
38eye photoreceptor cell differentiation (GO:0001754)3.28664784
39photoreceptor cell differentiation (GO:0046530)3.28664784
40dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.28571936
41GDP-mannose metabolic process (GO:0019673)3.25008700
42bundle of His cell to Purkinje myocyte communication (GO:0086069)3.24756864
43response to methylmercury (GO:0051597)3.21375071
44long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.16848717
45positive regulation of epidermal cell differentiation (GO:0045606)3.15306435
46nucleotide-sugar biosynthetic process (GO:0009226)3.14332921
47barbed-end actin filament capping (GO:0051016)3.13367797
48peripheral nervous system axon ensheathment (GO:0032292)3.13208165
49myelination in peripheral nervous system (GO:0022011)3.13208165
50long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.12335479
51retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.11150354
52endothelial cell chemotaxis (GO:0035767)3.07485317
53very long-chain fatty acid metabolic process (GO:0000038)3.06562344
54adhesion of symbiont to host (GO:0044406)2.99638375
55actin filament depolymerization (GO:0030042)2.99508609
56membrane tubulation (GO:0097320)2.98720800
57regulation of lipoprotein metabolic process (GO:0050746)2.97474219
58epithelial cell-cell adhesion (GO:0090136)2.96954079
59positive regulation of Cdc42 GTPase activity (GO:0043089)2.96096957
60asymmetric protein localization (GO:0008105)2.94507839
61cholesterol biosynthetic process (GO:0006695)2.94331111
62extracellular fibril organization (GO:0043206)2.92197361
63limb bud formation (GO:0060174)2.90046894
64membrane budding (GO:0006900)2.88995197
65negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.87546908
66wound healing, spreading of epidermal cells (GO:0035313)2.87529221
67fatty-acyl-CoA metabolic process (GO:0035337)2.86724952
68fatty-acyl-CoA biosynthetic process (GO:0046949)2.85494406
69positive regulation of epidermis development (GO:0045684)2.80297927
70regulation of integrin-mediated signaling pathway (GO:2001044)2.79786939
71response to gravity (GO:0009629)2.75629059
72amyloid precursor protein metabolic process (GO:0042982)2.74420669
73intermediate filament organization (GO:0045109)2.73964607
74peptidyl-tyrosine autophosphorylation (GO:0038083)2.73470478
75substrate-dependent cell migration (GO:0006929)2.71802750
76L-amino acid import (GO:0043092)2.70231541
77apical protein localization (GO:0045176)2.70131720
78lipopolysaccharide biosynthetic process (GO:0009103)2.68213959
79endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.66600051
80hypotonic response (GO:0006971)2.66325050
81regulation of transforming growth factor beta2 production (GO:0032909)2.63852832
82regulation of apoptotic process involved in morphogenesis (GO:1902337)2.63593134
83wound healing, spreading of cells (GO:0044319)2.62673746
84fibrinolysis (GO:0042730)2.62659401
85endothelial cell morphogenesis (GO:0001886)2.62499391
86negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.62032951
87proteasome assembly (GO:0043248)2.61609020
88endodermal cell differentiation (GO:0035987)2.61257868
89positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.60389996
90positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.60230311
91basement membrane organization (GO:0071711)2.59512375
92activation of Rac GTPase activity (GO:0032863)2.57080980
93sterol biosynthetic process (GO:0016126)2.56684141
94protein hydroxylation (GO:0018126)2.56579606
95proline biosynthetic process (GO:0006561)2.56223176
96positive regulation of pseudopodium assembly (GO:0031274)2.55787146
97pinocytosis (GO:0006907)2.55672442
98cell-substrate adherens junction assembly (GO:0007045)2.54451530
99focal adhesion assembly (GO:0048041)2.54451530
100branching involved in mammary gland duct morphogenesis (GO:0060444)2.53968396
101nucleobase-containing small molecule interconversion (GO:0015949)2.53382425
102retina vasculature morphogenesis in camera-type eye (GO:0061299)2.53356336
103peptidyl-proline hydroxylation (GO:0019511)2.52220961
104membrane raft organization (GO:0031579)2.51755859
105import into cell (GO:0098657)2.51725087
106regulation of collateral sprouting (GO:0048670)2.50300788
107COPII vesicle coating (GO:0048208)2.49329752
108peptide cross-linking (GO:0018149)2.48939503
109extracellular matrix assembly (GO:0085029)2.48126930
110fibril organization (GO:0097435)2.47135161
111positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.46950473
112regulation of somitogenesis (GO:0014807)2.45440480
1134-hydroxyproline metabolic process (GO:0019471)2.45125203
114negative regulation of cartilage development (GO:0061037)2.45095544
115positive regulation of blood vessel endothelial cell migration (GO:0043536)2.44299415
116positive regulation of keratinocyte differentiation (GO:0045618)2.43937954
117negative regulation of anoikis (GO:2000811)2.43841050
118regulation of pseudopodium assembly (GO:0031272)2.43827315
119regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.42615911
120protein heterotetramerization (GO:0051290)2.42212016
121vesicle coating (GO:0006901)2.40828797
122copper ion homeostasis (GO:0055070)2.40547055
123establishment of viral latency (GO:0019043)2.40379525
124cell junction assembly (GO:0034329)2.39754888
125acyl-CoA biosynthetic process (GO:0071616)2.38370714
126thioester biosynthetic process (GO:0035384)2.38370714
127adherens junction assembly (GO:0034333)2.38183631
128regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.37998627
129regulation of water loss via skin (GO:0033561)2.37956360
130astrocyte development (GO:0014002)2.37126283
131establishment of integrated proviral latency (GO:0075713)2.36874219
132lateral sprouting from an epithelium (GO:0060601)2.36445426
133establishment of skin barrier (GO:0061436)2.36196179
134amino acid import (GO:0043090)2.35279135
135regulation of cardioblast differentiation (GO:0051890)2.35063911
136protein localization to endosome (GO:0036010)2.34473283
137regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.34014156
138intestinal epithelial cell development (GO:0060576)2.32323144
139UDP-N-acetylglucosamine metabolic process (GO:0006047)2.30937898
140membrane protein ectodomain proteolysis (GO:0006509)2.30325630
141galactose catabolic process (GO:0019388)2.29698660
142response to lipoprotein particle (GO:0055094)2.28645873
143skin morphogenesis (GO:0043589)2.28604230
144epidermis development (GO:0008544)2.27436829
145regulation of glomerular filtration (GO:0003093)2.27103428
146isoprenoid biosynthetic process (GO:0008299)2.25550499
147phosphatidylserine acyl-chain remodeling (GO:0036150)2.24504386
148positive regulation of oligodendrocyte differentiation (GO:0048714)2.24386447
149axon development (GO:0061564)2.23956350
150substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.23633011
151substrate-independent telencephalic tangential migration (GO:0021826)2.23633011
152L-serine transport (GO:0015825)2.23562656
153negative regulation of neurotransmitter transport (GO:0051589)2.22998788
154substantia nigra development (GO:0021762)2.22307896
155phosphatidylserine metabolic process (GO:0006658)2.21435700
156neuron remodeling (GO:0016322)2.20429599
157astrocyte differentiation (GO:0048708)2.20194273
158positive regulation of actin filament depolymerization (GO:0030836)2.19886723
159membrane assembly (GO:0071709)2.19174999
160calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.18686507
161purine ribonucleotide transport (GO:0015868)2.17958304
162enteric nervous system development (GO:0048484)2.16831666
163presynaptic membrane organization (GO:0097090)2.11875239
164multicellular organismal water homeostasis (GO:0050891)2.11186107
165gap junction assembly (GO:0016264)2.10172142
166keratinocyte differentiation (GO:0030216)2.08481622
167purine nucleotide transport (GO:0015865)2.08004457
168magnesium ion transport (GO:0015693)2.06094350
169negative regulation of Rho protein signal transduction (GO:0035024)2.05817606
170atrioventricular valve morphogenesis (GO:0003181)2.05573094
171negative regulation of neurotransmitter secretion (GO:0046929)2.04601164
172positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.04142632
173positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.04000927
174mesodermal cell differentiation (GO:0048333)2.02981634
175positive regulation of glial cell differentiation (GO:0045687)2.02934685
176renal system process involved in regulation of blood volume (GO:0001977)2.02930884
177positive regulation of osteoblast proliferation (GO:0033690)2.02658356
178positive regulation of gliogenesis (GO:0014015)2.02243721
179sphingosine metabolic process (GO:0006670)2.01869482
180positive regulation of astrocyte differentiation (GO:0048711)2.01632134
181glutathione biosynthetic process (GO:0006750)2.01392040
182gonadal mesoderm development (GO:0007506)2.01270337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.53285241
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.17221843
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.98779051
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.89426549
5ZNF263_19887448_ChIP-Seq_K562_Human2.82247430
6HIF1A_21447827_ChIP-Seq_MCF-7_Human2.62206605
7AR_21572438_ChIP-Seq_LNCaP_Human2.36195167
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25372294
9* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.21370466
10* ELK3_25401928_ChIP-Seq_HUVEC_Human2.17303781
11* RACK7_27058665_Chip-Seq_MCF-7_Human2.09019226
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07759621
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07412367
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.07351420
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05008466
16* ATF3_27146783_Chip-Seq_COLON_Human2.02167166
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00154668
18* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.99629575
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.97310854
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96870987
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96870987
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91888175
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91158542
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84654844
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83366048
26* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82923994
27SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.82141394
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78465761
29* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.77488599
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77053031
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.74482584
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74414857
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72248708
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70699077
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70070230
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.65758348
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.61394322
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56427005
39UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56288065
40AR_21909140_ChIP-Seq_LNCAP_Human1.54260867
41* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52032330
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.50755532
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.50677826
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50516973
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49216444
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47337590
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.44930147
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.44845253
49ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44186292
50TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43444083
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40924218
52UBF1/2_26484160_Chip-Seq_HMECs_Human1.40486878
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39943461
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39220424
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39100539
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.37950878
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37526815
58* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36509797
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36453694
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34666900
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33206380
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33206380
63CJUN_26792858_Chip-Seq_BT549_Human1.31954225
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.31745628
65* LXR_22292898_ChIP-Seq_THP-1_Human1.31231562
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.30634784
67SOX2_20726797_ChIP-Seq_SW620_Human1.30363001
68EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.29836507
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29601350
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28868635
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27614229
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24693572
73GBX2_23144817_ChIP-Seq_PC3_Human1.24348943
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.23905112
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23802998
76DROSHA_22980978_ChIP-Seq_HELA_Human1.20618274
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19965463
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19873459
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18189209
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17986194
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17444561
82* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17261192
83* GATA6_25053715_ChIP-Seq_YYC3_Human1.16748360
84AHR_22903824_ChIP-Seq_MCF-7_Human1.16064212
85MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15983055
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15820824
87TP53_22127205_ChIP-Seq_IMR90_Human1.15771097
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.15744277
89* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15189681
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.15105875
91PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14611989
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13400773
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13005329
94MYC_18555785_ChIP-Seq_MESCs_Mouse1.12858894
95ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12736606
96* GATA3_24758297_ChIP-Seq_MCF-7_Human1.12140827
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11664885
98TP53_18474530_ChIP-ChIP_U2OS_Human1.10624066
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.10584472
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09791244
101* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09748084
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08983203
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08945383
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.07902293
105DCP1A_22483619_ChIP-Seq_HELA_Human1.05654901
106TP53_20018659_ChIP-ChIP_R1E_Mouse1.05525054
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05046697
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.04454781
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03855068
110ELK1_22589737_ChIP-Seq_MCF10A_Human1.03787573
111FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03608895
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02346833
113BRD4_25478319_ChIP-Seq_HGPS_Human1.02237078
114RING1B_27294783_Chip-Seq_ESCs_Mouse1.02196873
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.02173531
116TP63_23658742_ChIP-Seq_EP156T_Human1.01126178
117CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00745927
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00418296
119PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00030352
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99374122
121RXR_22108803_ChIP-Seq_LS180_Human0.97923970
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96050711
123* KLF5_25053715_ChIP-Seq_YYC3_Human0.95904652
124* RUNX1_27514584_Chip-Seq_MCF-7_Human0.95464608
125* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95282026
126CDX2_20551321_ChIP-Seq_CACO-2_Human0.95159261
127TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95137255
128CLOCK_20551151_ChIP-Seq_293T_Human0.94959317
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94816825
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93959602
131SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93712319
132ELF5_23300383_ChIP-Seq_T47D_Human0.92739588
133SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92023645
134PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91094560
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90249789
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90164975
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90031232
138TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89603393
139PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88664351
140VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88381582
141* GATA4_25053715_ChIP-Seq_YYC3_Human0.88375988
142GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88220114
143TP53_16413492_ChIP-PET_HCT116_Human0.87828770
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86947157
145DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85645144
146TCF4_18268006_ChIP-ChIP_LS174T_Human0.85077743
147VDR_22108803_ChIP-Seq_LS180_Human0.84232579
148RING1B_27294783_Chip-Seq_NPCs_Mouse0.83726649
149* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82589630
150* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82160423
151PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80748388
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80714683
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80699488
154SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80278214
155SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80278214
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79851615
157TBX20_22328084_ChIP-Seq_HEART_Mouse0.78502976
158TBX20_22080862_ChIP-Seq_HEART_Mouse0.78502976
159SMAD3_21741376_ChIP-Seq_EPCs_Human0.78193772
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78157997
161* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77874305
162CTCF_27219007_Chip-Seq_Bcells_Human0.77758287
163* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77559872
164AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77506540
165ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.76767617
166EGR1_19032775_ChIP-ChIP_M12_Human0.76281840
167TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76191363
168LXR_22158963_ChIP-Seq_LIVER_Mouse0.76011881
169CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75937652
170PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75794823
171FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74572340

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.75927003
2MP0002796_impaired_skin_barrier3.47459503
3MP0003950_abnormal_plasma_membrane3.34585207
4MP0005275_abnormal_skin_tensile3.19093861
5MP0000920_abnormal_myelination3.05110942
6MP0000579_abnormal_nail_morphology2.91848622
7MP0010678_abnormal_skin_adnexa2.90893236
8MP0000383_abnormal_hair_follicle2.83333314
9MP0001346_abnormal_lacrimal_gland2.33448951
10MP0000647_abnormal_sebaceous_gland2.28285345
11MP0003690_abnormal_glial_cell2.25939401
12MP0003329_amyloid_beta_deposits2.25349875
13MP0005023_abnormal_wound_healing2.24295376
14MP0002877_abnormal_melanocyte_morpholog2.20246664
15MP0004381_abnormal_hair_follicle2.16197232
16MP0008438_abnormal_cutaneous_collagen2.04797424
17MP0005257_abnormal_intraocular_pressure2.04234736
18MP0005501_abnormal_skin_physiology2.03980195
19MP0000467_abnormal_esophagus_morphology2.02096126
20MP0005360_urolithiasis2.01907847
21MP0000762_abnormal_tongue_morphology1.98672024
22MP0002098_abnormal_vibrissa_morphology1.93965717
23MP0000566_synostosis1.89081430
24MP0009053_abnormal_anal_canal1.87985974
25MP0004272_abnormal_basement_membrane1.81588727
26MP0003453_abnormal_keratinocyte_physiol1.79476918
27MP0002060_abnormal_skin_morphology1.74941177
28MP0004264_abnormal_extraembryonic_tissu1.74041873
29MP0010234_abnormal_vibrissa_follicle1.72956999
30MP0000537_abnormal_urethra_morphology1.72256821
31MP0005171_absent_coat_pigmentation1.65270557
32MP0010771_integument_phenotype1.64577546
33MP0010352_gastrointestinal_tract_polyps1.60866903
34MP0005409_darkened_coat_color1.60841081
35MP0003136_yellow_coat_color1.57845479
36MP0000377_abnormal_hair_follicle1.52069483
37MP0001958_emphysema1.49346147
38MP0001216_abnormal_epidermal_layer1.46193193
39MP0003705_abnormal_hypodermis_morpholog1.46151841
40MP0004885_abnormal_endolymph1.45555720
41MP0008260_abnormal_autophagy1.37461289
42MP0004858_abnormal_nervous_system1.36457821
43MP0004742_abnormal_vestibular_system1.33800835
44MP0003634_abnormal_glial_cell1.32530776
45MP0006054_spinal_hemorrhage1.32003537
46MP0002295_abnormal_pulmonary_circulatio1.30996721
47MP0003091_abnormal_cell_migration1.29419759
48MP0004782_abnormal_surfactant_physiolog1.29085271
49MP0003011_delayed_dark_adaptation1.28221614
50MP0003941_abnormal_skin_development1.27209832
51MP0009384_cardiac_valve_regurgitation1.26558912
52MP0004270_analgesia1.23767396
53MP0009250_abnormal_appendicular_skeleto1.23394180
54MP0001851_eye_inflammation1.22948423
55MP0005451_abnormal_body_composition1.22424197
56MP0000858_altered_metastatic_potential1.22061765
57MP0000462_abnormal_digestive_system1.21853730
58MP0000750_abnormal_muscle_regeneration1.18742937
59MP0003315_abnormal_perineum_morphology1.17839958
60MP0004233_abnormal_muscle_weight1.14945948
61MP0000627_abnormal_mammary_gland1.07672716
62MP0002896_abnormal_bone_mineralization1.05616379
63MP0000604_amyloidosis1.04371395
64MP0000767_abnormal_smooth_muscle1.04332177
65MP0003075_altered_response_to1.04160586
66MP0003880_abnormal_central_pattern1.03853085
67MP0000427_abnormal_hair_cycle1.03379390
68MP0010368_abnormal_lymphatic_system1.03243067
69MP0009840_abnormal_foam_cell1.03108085
70MP0005623_abnormal_meninges_morphology1.01932656
71MP0005330_cardiomyopathy1.00496876
72MP0005165_increased_susceptibility_to0.99313702
73MP0001299_abnormal_eye_distance/0.97373210
74MP0003806_abnormal_nucleotide_metabolis0.96651206
75MP0000749_muscle_degeneration0.96523885
76MP0009931_abnormal_skin_appearance0.95676234
77MP0001542_abnormal_bone_strength0.94201973
78MP0005503_abnormal_tendon_morphology0.93964725
79MP0005058_abnormal_lysosome_morphology0.93557016
80MP0005083_abnormal_biliary_tract0.92683404
81MP0001879_abnormal_lymphatic_vessel0.92210977
82MP0003632_abnormal_nervous_system0.91987329
83MP0000751_myopathy0.91879470
84MP0010030_abnormal_orbit_morphology0.91393974
85MP0004134_abnormal_chest_morphology0.91266882
86MP0009780_abnormal_chondrocyte_physiolo0.89654416
87MP0000678_abnormal_parathyroid_gland0.89345705
88MP0003566_abnormal_cell_adhesion0.87610150
89MP0004185_abnormal_adipocyte_glucose0.86567805
90MP0008569_lethality_at_weaning0.86492967
91MP0005167_abnormal_blood-brain_barrier0.86110461
92MP0001177_atelectasis0.85894656
93MP0002234_abnormal_pharynx_morphology0.85327120
94MP0001881_abnormal_mammary_gland0.84168213
95MP0001486_abnormal_startle_reflex0.84106709
96MP0000778_abnormal_nervous_system0.83746993
97MP0002133_abnormal_respiratory_system0.82340460
98MP0005388_respiratory_system_phenotype0.82340460
99MP0005197_abnormal_uvea_morphology0.82208032
100MP0004043_abnormal_pH_regulation0.80912189
101MP0002282_abnormal_trachea_morphology0.78208739
102MP0002272_abnormal_nervous_system0.78199136
103MP0001849_ear_inflammation0.77933994
104MP0001485_abnormal_pinna_reflex0.77812345
105MP0003631_nervous_system_phenotype0.76191223
106MP0001340_abnormal_eyelid_morphology0.76065299
107MP0003186_abnormal_redox_activity0.74563041
108MP0002233_abnormal_nose_morphology0.74379676
109MP0000747_muscle_weakness0.74034549
110MP0000003_abnormal_adipose_tissue0.73768501
111MP0003633_abnormal_nervous_system0.72888189
112MP0001243_abnormal_dermal_layer0.71536189
113MP0002108_abnormal_muscle_morphology0.71431669
114MP0004036_abnormal_muscle_relaxation0.71067392
115MP0001348_abnormal_lacrimal_gland0.70322371
116MP0005508_abnormal_skeleton_morphology0.69903697
117MP0002249_abnormal_larynx_morphology0.69346846
118MP0002332_abnormal_exercise_endurance0.68604173
119MP0006138_congestive_heart_failure0.68450411
120MP0000534_abnormal_ureter_morphology0.68325717
121MP0003191_abnormal_cellular_cholesterol0.68258679
122MP0005408_hypopigmentation0.68126286
123MP0005164_abnormal_response_to0.67579392
124MP0000013_abnormal_adipose_tissue0.66996570
125MP0005595_abnormal_vascular_smooth0.66168104
126MP0004142_abnormal_muscle_tone0.66143007
127MP0002972_abnormal_cardiac_muscle0.65354277
128MP0002089_abnormal_postnatal_growth/wei0.65027114
129MP0005620_abnormal_muscle_contractility0.64880529
130MP0003279_aneurysm0.64791362
131MP0001661_extended_life_span0.64700924
132MP0000733_abnormal_muscle_development0.64663999
133MP0001529_abnormal_vocalization0.64397470
134MP0003123_paternal_imprinting0.64311135
135MP0004947_skin_inflammation0.61949512
136MP0003828_pulmonary_edema0.60922039
137MP0000516_abnormal_urinary_system0.58946455
138MP0005367_renal/urinary_system_phenotyp0.58946455
139MP0000367_abnormal_coat/_hair0.58538820
140MP0004957_abnormal_blastocyst_morpholog0.58241123
141MP0005193_abnormal_anterior_eye0.57230423
142MP0000358_abnormal_cell_content/0.57000517
143MP0005621_abnormal_cell_physiology0.56381354
144MP0003786_premature_aging0.55551142
145MP0001614_abnormal_blood_vessel0.55446539

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.98708606
2Fragile nails (HP:0001808)4.51370663
3Onycholysis (HP:0001806)4.40184523
4Parakeratosis (HP:0001036)3.95223183
5Right ventricular cardiomyopathy (HP:0011663)3.80742129
6Distal lower limb muscle weakness (HP:0009053)3.76807035
7Protrusio acetabuli (HP:0003179)3.70537192
8Hypotrichosis (HP:0001006)3.59241959
9Short nail (HP:0001799)3.52684646
10Cerebral inclusion bodies (HP:0100314)3.51860901
11Plantar hyperkeratosis (HP:0007556)3.50495030
12Aplasia involving bones of the extremities (HP:0009825)3.43568992
13Aplasia involving bones of the upper limbs (HP:0009823)3.43568992
14Aplasia of the phalanges of the hand (HP:0009802)3.43568992
15Milia (HP:0001056)3.40500464
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.37485278
17Congenital ichthyosiform erythroderma (HP:0007431)3.23323294
18Onion bulb formation (HP:0003383)3.21349543
19Reduced subcutaneous adipose tissue (HP:0003758)3.15574529
20Degeneration of the lateral corticospinal tracts (HP:0002314)3.08287687
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.08287687
22Atrophic scars (HP:0001075)3.06966875
23Vertebral compression fractures (HP:0002953)3.03053416
24Hyporeflexia of lower limbs (HP:0002600)3.02024187
25Osteolytic defects of the hand bones (HP:0009699)3.00796933
26Osteolytic defects of the phalanges of the hand (HP:0009771)3.00796933
27Cervical subluxation (HP:0003308)2.99078324
28Natal tooth (HP:0000695)2.96796227
29Abnormality of the distal phalanges of the toes (HP:0010182)2.93731800
30Sparse eyelashes (HP:0000653)2.92421869
31Muscle fiber splitting (HP:0003555)2.89721282
32Amniotic constriction ring (HP:0009775)2.85025547
33Abnormality of placental membranes (HP:0011409)2.85025547
34Popliteal pterygium (HP:0009756)2.80201980
35Premature rupture of membranes (HP:0001788)2.78573760
36Woolly hair (HP:0002224)2.76347364
37Abnormal hair laboratory examination (HP:0003328)2.73801490
38Trismus (HP:0000211)2.67601516
39Megalencephaly (HP:0001355)2.66965894
40Arterial tortuosity (HP:0005116)2.65860508
41Segmental peripheral demyelination/remyelination (HP:0003481)2.65223758
42Distal lower limb amyotrophy (HP:0008944)2.62578572
43Peripheral hypomyelination (HP:0007182)2.61780345
44Abnormality of nail color (HP:0100643)2.61048709
45Vascular tortuosity (HP:0004948)2.60193164
46Pterygium (HP:0001059)2.59863708
47Abnormal auditory evoked potentials (HP:0006958)2.56205909
48Glucose intolerance (HP:0000833)2.53805938
49Humeroradial synostosis (HP:0003041)2.53471991
50Synostosis involving the elbow (HP:0003938)2.53471991
51Palmoplantar hyperkeratosis (HP:0000972)2.52975332
52Spinal rigidity (HP:0003306)2.52920316
53Pili torti (HP:0003777)2.48310607
54Upper limb amyotrophy (HP:0009129)2.45790728
55Distal upper limb amyotrophy (HP:0007149)2.45790728
56Abnormality of the middle phalanges of the toes (HP:0010183)2.41488202
57Abnormalities of placenta or umbilical cord (HP:0001194)2.41118355
58Ridged nail (HP:0001807)2.38722242
59Abnormality of the umbilical cord (HP:0010881)2.36144909
60Nail dystrophy (HP:0008404)2.36127896
61Thick nail (HP:0001805)2.34837008
62Supranuclear gaze palsy (HP:0000605)2.34438428
63Alacrima (HP:0000522)2.34202570
64Achilles tendon contracture (HP:0001771)2.32816220
65Increased connective tissue (HP:0009025)2.31810759
66Hypoplasia of the iris (HP:0007676)2.28293758
67Esophageal atresia (HP:0002032)2.26442878
68Generalized amyotrophy (HP:0003700)2.26107967
69Foot dorsiflexor weakness (HP:0009027)2.25171294
70Palmar hyperkeratosis (HP:0010765)2.24884602
71Follicular hyperkeratosis (HP:0007502)2.22302504
72Entropion (HP:0000621)2.22060564
73Spinal cord compression (HP:0002176)2.21945449
74Mildly elevated creatine phosphokinase (HP:0008180)2.21772409
75Intention tremor (HP:0002080)2.21109598
76Selective tooth agenesis (HP:0001592)2.19586415
77Premature skin wrinkling (HP:0100678)2.17879094
78Abnormality of the Achilles tendon (HP:0005109)2.17309244
79Advanced eruption of teeth (HP:0006288)2.16906987
80Aortic dissection (HP:0002647)2.16265099
81Rough bone trabeculation (HP:0100670)2.14607481
82Elbow flexion contracture (HP:0002987)2.13751679
83Abnormal blistering of the skin (HP:0008066)2.13625985
84Axonal loss (HP:0003447)2.12995900
85Broad face (HP:0000283)2.12819789
86Split foot (HP:0001839)2.11854632
87Difficulty running (HP:0009046)2.10204644
88Round ear (HP:0100830)2.10191323
89Short hallux (HP:0010109)2.07511482
90Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07380038
91Abnormality of carpal bone ossification (HP:0006257)2.07280303
92Hand muscle atrophy (HP:0009130)2.06124339
93Alopecia of scalp (HP:0002293)2.05020731
94Wormian bones (HP:0002645)2.03121087
95Ankle contracture (HP:0006466)2.01733833
96Abnormality of the foot musculature (HP:0001436)2.01419583
97Bronchomalacia (HP:0002780)2.00994030
98Erythroderma (HP:0001019)2.00143341
99Broad metatarsal (HP:0001783)1.99759736
100Fragile skin (HP:0001030)1.98193386
101Symphalangism affecting the phalanges of the hand (HP:0009773)1.97184776
102Flat acetabular roof (HP:0003180)1.96836096
103Abnormality of secondary sexual hair (HP:0009888)1.96787623
104Abnormality of the axillary hair (HP:0100134)1.96787623
105Microglossia (HP:0000171)1.96255338
106Sensory axonal neuropathy (HP:0003390)1.94426715
107Cerebral hypomyelination (HP:0006808)1.92936178
108Oral leukoplakia (HP:0002745)1.92533255
109Stridor (HP:0010307)1.90974802
110Fatigable weakness (HP:0003473)1.90585009
111Abnormality of the neuromuscular junction (HP:0003398)1.90585009
112Abnormality of the corticospinal tract (HP:0002492)1.90355378
113Ulnar claw (HP:0001178)1.88733819
114Brittle hair (HP:0002299)1.88472577
115Coronal craniosynostosis (HP:0004440)1.88049014
116Exercise-induced myalgia (HP:0003738)1.87715077
117Limb-girdle muscle atrophy (HP:0003797)1.86689280
118Difficulty climbing stairs (HP:0003551)1.85400563
119Aplasia/Hypoplasia of the hallux (HP:0008362)1.84566502
120Mixed hearing impairment (HP:0000410)1.83837502
121Lip pit (HP:0100267)1.83550772
122Hypoalphalipoproteinemia (HP:0003233)1.82877384
123Mitral stenosis (HP:0001718)1.82867412
124Metabolic alkalosis (HP:0200114)1.81955647
125Acanthosis nigricans (HP:0000956)1.81825396
126Blue sclerae (HP:0000592)1.80998846
127Difficulty walking (HP:0002355)1.80975299
128Ankle clonus (HP:0011448)1.80540130
129Corneal erosion (HP:0200020)1.79212187
130Hypoplasia of dental enamel (HP:0006297)1.77971657
131Hypohidrosis (HP:0000966)1.77935759
132Hypokinesia (HP:0002375)1.77868355
133Ileus (HP:0002595)1.77392565
134Bladder diverticulum (HP:0000015)1.77152930
135Amyloidosis (HP:0011034)1.76805275
136Gowers sign (HP:0003391)1.76636819
137Erythema (HP:0010783)1.75213919
138Hypokalemic alkalosis (HP:0001949)1.75185068
139White forelock (HP:0002211)1.75086428
140Hypoplastic pelvis (HP:0008839)1.74949015
141Scapular winging (HP:0003691)1.74930092
142Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74925091
143Aplasia cutis congenita (HP:0001057)1.74441156
144Abnormal ossification of hand bones (HP:0005921)1.73615783
145Ventricular tachycardia (HP:0004756)1.73157790
146Hyperacusis (HP:0010780)1.73128790
147Bifid scrotum (HP:0000048)1.72565354
148Ankyloglossia (HP:0010296)1.72458100
149Insidious onset (HP:0003587)1.71902499
150Termporal pattern (HP:0011008)1.71902499
151Coxa vara (HP:0002812)1.70872924
152Epiphyseal dysplasia (HP:0002656)1.70634910
153Lower limb amyotrophy (HP:0007210)1.70462148
154Abnormality of dentin (HP:0010299)1.70067550
155Patchy hypopigmentation of hair (HP:0011365)1.69066509
156Neck muscle weakness (HP:0000467)1.68972003
157Abnormality of the 2nd finger (HP:0004100)1.68857134
158Nemaline bodies (HP:0003798)1.68054583
159Cerebral hemorrhage (HP:0001342)1.68038882
160Autoamputation (HP:0001218)1.67317137
161Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.67272437
162Back pain (HP:0003418)1.66974859
163Vascular calcification (HP:0004934)1.66312262
164Cardiovascular calcification (HP:0011915)1.66184641
165Abnormal glucose tolerance (HP:0001952)1.66052152
166Abnormal delivery (HP:0001787)1.66029286
167Clumsiness (HP:0002312)1.65205027
168Abnormality of oral frenula (HP:0000190)1.64966525
169Dry hair (HP:0011359)1.63888008
170Cerebral aneurysm (HP:0004944)1.62363889
171Short clavicles (HP:0000894)1.62149490
172Aortic aneurysm (HP:0004942)1.61928545
173Upper limb muscle weakness (HP:0003484)1.61530401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.06498645
2EPHB13.88981007
3NME23.33198131
4OXSR12.84327515
5MST42.76040157
6PAK42.74614597
7MAP3K122.65126702
8MAPKAPK52.57583780
9MET2.41195888
10BCR2.24449445
11IRAK32.23985033
12LIMK12.22460912
13PHKG22.16045100
14PHKG12.16045100
15PBK2.14226645
16PKN12.12629730
17CASK2.12538938
18ARAF2.05192609
19TIE11.91874090
20MYLK1.89974495
21TRIB31.87626474
22LMTK21.86748759
23FER1.85636436
24FGFR21.81009908
25WNK41.70029080
26VRK21.66052815
27MST1R1.58950165
28ROCK21.56904066
29PIM21.54821689
30EPHB21.35390036
31MAP3K21.31797308
32RIPK11.30875147
33MAP2K21.30307729
34DDR21.25860565
35EPHA31.24621933
36NTRK11.24486677
37SCYL21.23747845
38CAMK2B1.23352164
39ABL21.22471245
40LATS21.21855445
41BUB11.21644131
42EPHA21.16185410
43PRKD11.13441157
44CAMK2G1.11990622
45SGK4941.11614874
46SGK2231.11614874
47TRPM71.11567486
48FLT31.10495055
49CAMK2D1.10374967
50MOS1.10244317
51NEK11.07434360
52PRKD31.07243814
53EIF2AK11.06210955
54PKN21.04419164
55TYRO31.03821701
56PAK31.03465537
57EPHA41.02275027
58MAP3K31.02071052
59MAPK151.00091837
60NEK60.99916732
61WNK10.98000153
62NME10.94674728
63DMPK0.94390537
64ILK0.93126112
65CDK80.92953700
66TESK10.89588055
67PIK3CA0.89578579
68SMG10.88817318
69CDK190.85932808
70PRKCI0.84192331
71SIK30.83902180
72PRKCE0.81998312
73MUSK0.80919647
74PTK20.80501193
75STK100.79720366
76PRKG20.79619575
77DAPK10.78851561
78UHMK10.76813861
79TESK20.75548881
80STK380.75219746
81MAP3K10.75173494
82OBSCN0.75010425
83BCKDK0.73480859
84CAMK2A0.73239771
85CSNK1A1L0.72360985
86LRRK20.71933768
87RPS6KB20.71783861
88FGR0.70959931
89ERBB30.69194176
90PTK60.67921349
91MAP2K10.67210328
92GSK3A0.66690147
93ROCK10.66405028
94TAOK20.66173368
95ERBB40.65458607
96KDR0.65273655
97ICK0.62949632
98TTN0.62833437
99DYRK20.62754233
100PIK3CG0.62677956
101KSR20.62160364
102PTK2B0.61322588
103CSNK1G30.60528819
104PAK20.60250215
105ERN10.59154063
106MAP3K70.58913554
107BMPR1B0.57701632
108PDGFRA0.56956751
109LATS10.56877225
110PDGFRB0.56203650
111GRK10.55436355
112PAK60.54512110
113MAP3K90.52309086
114BMX0.52008775
115PDK20.51832551
116CSNK1G10.51826407
117PRKCQ0.51725414
118MAPK120.50839443
119CDK50.50736277
120DAPK30.50702346
121BRAF0.50593698
122PDPK10.50309491
123PAK10.50236567
124CSNK1G20.48286759
125NTRK20.48156157
126MAP3K80.47828278
127IRAK10.47643170
128STK240.47594860
129SIK10.46090526
130FGFR40.45445406
131STK160.44891922
132MAPKAPK30.44580188
133CDK70.44517619
134PRKG10.43407929
135PRKD20.43159984
136TGFBR20.43123074
137MAPKAPK20.43120601
138MARK20.42614289
139SRC0.42571773
140MAPK70.41661915
141TGFBR10.41450650
142MAP3K60.39070539
143AURKA0.36297840
144STK38L0.35677956
145EIF2AK30.35656212
146BRSK10.34515016
147MTOR0.33528811
148AKT20.29803338
149PRPF4B0.28621049
150AURKB0.24632530
151TBK10.24618160

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.68806986
2Proteasome_Homo sapiens_hsa030503.37887657
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.20229376
4Nitrogen metabolism_Homo sapiens_hsa009102.90484407
5Steroid biosynthesis_Homo sapiens_hsa001002.90305105
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.61395540
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52646355
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48332712
9Sulfur metabolism_Homo sapiens_hsa009202.46728577
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.45821921
11Galactose metabolism_Homo sapiens_hsa000522.31501134
12Ether lipid metabolism_Homo sapiens_hsa005652.22698027
13Histidine metabolism_Homo sapiens_hsa003402.11246056
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09353875
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.01375931
16Fructose and mannose metabolism_Homo sapiens_hsa000511.96738224
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.90174758
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88835422
19Pentose phosphate pathway_Homo sapiens_hsa000301.87786649
20Linoleic acid metabolism_Homo sapiens_hsa005911.81982512
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.79808913
22Sphingolipid metabolism_Homo sapiens_hsa006001.74200162
23Sulfur relay system_Homo sapiens_hsa041221.73949144
24Biosynthesis of amino acids_Homo sapiens_hsa012301.68181849
25N-Glycan biosynthesis_Homo sapiens_hsa005101.58174418
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.56130266
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.56094655
28Proteoglycans in cancer_Homo sapiens_hsa052051.48924322
29Fatty acid metabolism_Homo sapiens_hsa012121.48428704
30ECM-receptor interaction_Homo sapiens_hsa045121.47971385
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46630968
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46376844
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44871955
34Bladder cancer_Homo sapiens_hsa052191.42046724
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.40336685
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36859219
37Small cell lung cancer_Homo sapiens_hsa052221.36804480
38Fatty acid biosynthesis_Homo sapiens_hsa000611.36566729
39Butanoate metabolism_Homo sapiens_hsa006501.34455108
40Folate biosynthesis_Homo sapiens_hsa007901.34340921
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.32091914
42Adherens junction_Homo sapiens_hsa045201.31580769
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29810336
44Carbon metabolism_Homo sapiens_hsa012001.29451489
45Axon guidance_Homo sapiens_hsa043601.28327666
46Propanoate metabolism_Homo sapiens_hsa006401.26307437
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25523580
48Thyroid cancer_Homo sapiens_hsa052161.25438304
49Other glycan degradation_Homo sapiens_hsa005111.23504741
50Tight junction_Homo sapiens_hsa045301.23098360
51Arginine and proline metabolism_Homo sapiens_hsa003301.21851892
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20517943
53Arachidonic acid metabolism_Homo sapiens_hsa005901.18841029
54Fatty acid degradation_Homo sapiens_hsa000711.17811778
55Chemical carcinogenesis_Homo sapiens_hsa052041.16065217
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15711770
57Shigellosis_Homo sapiens_hsa051311.11828929
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.07331178
59Pyrimidine metabolism_Homo sapiens_hsa002401.07055626
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03637175
61Glutathione metabolism_Homo sapiens_hsa004801.01762360
62Mineral absorption_Homo sapiens_hsa049780.94716096
63Oxidative phosphorylation_Homo sapiens_hsa001900.94293310
64PPAR signaling pathway_Homo sapiens_hsa033200.94219235
65p53 signaling pathway_Homo sapiens_hsa041150.93410346
66Gastric acid secretion_Homo sapiens_hsa049710.92491050
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90114845
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87697125
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86930230
70Pancreatic secretion_Homo sapiens_hsa049720.85371978
71Salivary secretion_Homo sapiens_hsa049700.85073951
72Peroxisome_Homo sapiens_hsa041460.83528670
73Complement and coagulation cascades_Homo sapiens_hsa046100.81501716
74Protein digestion and absorption_Homo sapiens_hsa049740.78987512
75Retinol metabolism_Homo sapiens_hsa008300.76169735
76Vitamin digestion and absorption_Homo sapiens_hsa049770.75858445
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.74136408
78Dilated cardiomyopathy_Homo sapiens_hsa054140.74083328
79Alzheimers disease_Homo sapiens_hsa050100.73730136
80beta-Alanine metabolism_Homo sapiens_hsa004100.72883264
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.71047441
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70680920
83Chronic myeloid leukemia_Homo sapiens_hsa052200.70401161
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69540065
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69027145
86Tyrosine metabolism_Homo sapiens_hsa003500.68912855
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68384897
88Phenylalanine metabolism_Homo sapiens_hsa003600.68027335
89TGF-beta signaling pathway_Homo sapiens_hsa043500.67873002
90Pancreatic cancer_Homo sapiens_hsa052120.67065865
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67021347
92Starch and sucrose metabolism_Homo sapiens_hsa005000.66716363
93Dorso-ventral axis formation_Homo sapiens_hsa043200.65957877
94Focal adhesion_Homo sapiens_hsa045100.65604395
95Vitamin B6 metabolism_Homo sapiens_hsa007500.65507977
96Cardiac muscle contraction_Homo sapiens_hsa042600.64831281
97Hedgehog signaling pathway_Homo sapiens_hsa043400.64393829
98Fat digestion and absorption_Homo sapiens_hsa049750.63685551
99Lysosome_Homo sapiens_hsa041420.63424295
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62515675
101Glutamatergic synapse_Homo sapiens_hsa047240.61817154
102Basal cell carcinoma_Homo sapiens_hsa052170.61330556
103Renal cell carcinoma_Homo sapiens_hsa052110.60632782
104Serotonergic synapse_Homo sapiens_hsa047260.60174897
105Ras signaling pathway_Homo sapiens_hsa040140.59609744
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59321815
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.59211414
108Bile secretion_Homo sapiens_hsa049760.59072916
109Parkinsons disease_Homo sapiens_hsa050120.59014478
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58334164
111Hippo signaling pathway_Homo sapiens_hsa043900.57894293
112Nucleotide excision repair_Homo sapiens_hsa034200.57706196
113Arginine biosynthesis_Homo sapiens_hsa002200.55671853
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55307942
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.55227924
116Cocaine addiction_Homo sapiens_hsa050300.53085156
117GABAergic synapse_Homo sapiens_hsa047270.52745780
118Salmonella infection_Homo sapiens_hsa051320.52410909
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.52382448
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52209852
121Prion diseases_Homo sapiens_hsa050200.51681422
122Long-term depression_Homo sapiens_hsa047300.51672583
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51091507
124Ovarian steroidogenesis_Homo sapiens_hsa049130.48526595
125Vibrio cholerae infection_Homo sapiens_hsa051100.48338690
126Gap junction_Homo sapiens_hsa045400.47812533
127Melanogenesis_Homo sapiens_hsa049160.47256031
128Apoptosis_Homo sapiens_hsa042100.46934829
129Endocytosis_Homo sapiens_hsa041440.46778431
130Metabolic pathways_Homo sapiens_hsa011000.46408712
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.45914852
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45894170
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.45147807
134Tryptophan metabolism_Homo sapiens_hsa003800.45039025
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44685159
136Renin secretion_Homo sapiens_hsa049240.44522181
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.44175148
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43806852
139Amoebiasis_Homo sapiens_hsa051460.43060163
140Endometrial cancer_Homo sapiens_hsa052130.43008720
141Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42959008
142Base excision repair_Homo sapiens_hsa034100.41744095
143Pyruvate metabolism_Homo sapiens_hsa006200.41542540
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40873852
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40809931
146Malaria_Homo sapiens_hsa051440.40280807
147Glycerolipid metabolism_Homo sapiens_hsa005610.40220355
148Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39831504
149Hepatitis C_Homo sapiens_hsa051600.39761665
150Protein export_Homo sapiens_hsa030600.39241921
151Rap1 signaling pathway_Homo sapiens_hsa040150.37851007
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37168559
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37124055
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.37072837
155Pathways in cancer_Homo sapiens_hsa052000.36684317
156Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36219401

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