S100A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.86331019
2cellular response to zinc ion (GO:0071294)9.34181647
3keratinocyte proliferation (GO:0043616)7.91775242
4cellular copper ion homeostasis (GO:0006878)6.91667833
5negative regulation of keratinocyte proliferation (GO:0010839)6.30381136
6cell-substrate junction assembly (GO:0007044)6.15960193
7bundle of His cell to Purkinje myocyte communication (GO:0086069)5.98631685
8establishment of skin barrier (GO:0061436)5.98556628
9ribosomal small subunit biogenesis (GO:0042274)5.80350093
10copper ion homeostasis (GO:0055070)5.50722125
11regulation of water loss via skin (GO:0033561)5.38992661
12keratinization (GO:0031424)5.09282813
13keratinocyte development (GO:0003334)4.89741628
14viral transcription (GO:0019083)4.81700542
15regulation of keratinocyte proliferation (GO:0010837)4.69175329
16translational termination (GO:0006415)4.65339652
17positive regulation of epidermal cell differentiation (GO:0045606)4.61775351
18molting cycle (GO:0042303)4.59895893
19hair cycle (GO:0042633)4.59895893
20positive regulation of epidermis development (GO:0045684)4.55060616
21ribosomal large subunit biogenesis (GO:0042273)4.39748622
22surfactant homeostasis (GO:0043129)4.32191980
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.30289564
24cotranslational protein targeting to membrane (GO:0006613)4.25527012
25protein targeting to ER (GO:0045047)4.24798349
26intermediate filament organization (GO:0045109)4.22040603
27regulation of hair follicle development (GO:0051797)4.18129675
28epidermis development (GO:0008544)4.17349869
29establishment of protein localization to endoplasmic reticulum (GO:0072599)4.14844639
30regulation of epidermis development (GO:0045682)4.05992664
31protein localization to endoplasmic reticulum (GO:0070972)4.02512148
32positive regulation of hair cycle (GO:0042635)3.98795245
33positive regulation of hair follicle development (GO:0051798)3.98795245
34G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.97165185
35positive regulation of keratinocyte differentiation (GO:0045618)3.91627170
36translational elongation (GO:0006414)3.86921689
37regulation of epidermal cell differentiation (GO:0045604)3.85224358
38viral life cycle (GO:0019058)3.82927397
39gap junction assembly (GO:0016264)3.77612332
40keratinocyte differentiation (GO:0030216)3.75104867
41hypotonic response (GO:0006971)3.72073600
42translational initiation (GO:0006413)3.71391482
43ribonucleoprotein complex biogenesis (GO:0022613)3.70799960
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.66725909
45multicellular organismal water homeostasis (GO:0050891)3.65882088
46membrane raft organization (GO:0031579)3.63442864
47chemical homeostasis within a tissue (GO:0048875)3.61535407
48dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.59705354
49cellular protein complex disassembly (GO:0043624)3.59248158
50translation (GO:0006412)3.46958350
51response to zinc ion (GO:0010043)3.45971654
52maturation of SSU-rRNA (GO:0030490)3.42355490
53regulation of keratinocyte differentiation (GO:0045616)3.42346753
54cellular response to cadmium ion (GO:0071276)3.39898857
55regulation of G0 to G1 transition (GO:0070316)3.37649508
56pyrimidine nucleoside salvage (GO:0043097)3.33838790
57pyrimidine-containing compound salvage (GO:0008655)3.33838790
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22709576
59cell adhesion mediated by integrin (GO:0033627)3.19344668
60protein targeting to membrane (GO:0006612)3.15901043
61regulation of transcription from RNA polymerase I promoter (GO:0006356)3.13941922
62nucleobase-containing small molecule interconversion (GO:0015949)3.13941520
63nucleoside salvage (GO:0043174)3.13881962
64regulation of protein export from nucleus (GO:0046825)3.12534088
65regulation of metalloenzyme activity (GO:0048552)3.09042236
66membrane budding (GO:0006900)3.07714164
67water homeostasis (GO:0030104)3.02250381
68transcription from mitochondrial promoter (GO:0006390)2.98199899
69regulation of hair cycle (GO:0042634)2.97546503
70protein complex disassembly (GO:0043241)2.97458484
71peptide cross-linking (GO:0018149)2.96134765
72formation of translation preinitiation complex (GO:0001731)2.93916101
73protein localization to microtubule (GO:0035372)2.93768224
74UMP metabolic process (GO:0046049)2.93296752
75pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.93296752
76UMP biosynthetic process (GO:0006222)2.93296752
77pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.93296752
78G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.92654364
79macromolecular complex disassembly (GO:0032984)2.92503783
80GDP-mannose metabolic process (GO:0019673)2.90009168
81telomere maintenance via telomerase (GO:0007004)2.89525171
82rRNA modification (GO:0000154)2.88050469
83cell differentiation involved in embryonic placenta development (GO:0060706)2.87857746
84ribosomal small subunit assembly (GO:0000028)2.87834377
85negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.84379705
86establishment of planar polarity (GO:0001736)2.84048927
87establishment of tissue polarity (GO:0007164)2.84048927
88cellular component biogenesis (GO:0044085)2.77559439
89negative regulation of acute inflammatory response (GO:0002674)2.76898862
90ribosome biogenesis (GO:0042254)2.76891341
91RNA-dependent DNA replication (GO:0006278)2.76208333
92protein localization to endosome (GO:0036010)2.74055182
93epidermal cell differentiation (GO:0009913)2.71178047
94negative regulation of chondrocyte differentiation (GO:0032331)2.69411776
95nucleotide salvage (GO:0043173)2.69179089
96natural killer cell mediated immunity (GO:0002228)2.67682852
97natural killer cell mediated cytotoxicity (GO:0042267)2.67682852
98regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.66396793
99positive regulation of protein export from nucleus (GO:0046827)2.66381452
100hemidesmosome assembly (GO:0031581)15.8065880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* SMAD4_19686287_ChIP-ChIP_HaCaT_Human5.59382621
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.54914755
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.06428873
4* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.93556139
5* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.93556139
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.54073835
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.50710838
8* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.43672611
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.30947831
10AR_21909140_ChIP-Seq_LNCAP_Human2.26977092
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12615000
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07041118
13* TP63_17297297_ChIP-ChIP_HaCaT_Human13.2761265
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95899011
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94713648
16ZNF263_19887448_ChIP-Seq_K562_Human1.90461264
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85916903
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.83484272
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83070727
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82392523
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77606515
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76729941
23* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75057081
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71832723
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.65667736
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65328242
27ELK1_22589737_ChIP-Seq_MCF10A_Human1.63532178
28* ATF3_27146783_Chip-Seq_COLON_Human1.63246083
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63086216
30* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.61889100
31* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.59105991
32ELK1_19687146_ChIP-ChIP_HELA_Human1.58742992
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57721594
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53412676
35HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.53403339
36* UBF1/2_26484160_Chip-Seq_HMECs_Human1.51448230
37DCP1A_22483619_ChIP-Seq_HELA_Human1.51416967
38* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51380410
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.50269270
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45447949
41* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.43775332
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43740537
43* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41967266
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41485788
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40760814
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34141483
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30628264
48* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27326912
49XRN2_22483619_ChIP-Seq_HELA_Human1.21951547
50TP63_23658742_ChIP-Seq_EP156T_Human1.21754571
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19462862
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19254620
53* SOX2_20726797_ChIP-Seq_SW620_Human1.18085062
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18077394
55* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17832747
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11376932
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08723614
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08017377
59* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05743870
60EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04404664
61TTF2_22483619_ChIP-Seq_HELA_Human1.03354494
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02627753
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00941940
64NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00270970
65ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99262233
66ELF5_23300383_ChIP-Seq_T47D_Human0.98760611
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97924091
68THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97386937
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96328719
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95881713
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95460481
72TP63_22573176_ChIP-Seq_HFKS_Human0.94561479
73NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93571891
74GABP_19822575_ChIP-Seq_HepG2_Human0.93332269
75* RACK7_27058665_Chip-Seq_MCF-7_Human0.93004528
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91361721
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90440382
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85943111
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84539289
80VDR_23849224_ChIP-Seq_CD4+_Human0.84157310
81* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84076862
82TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83182989
83* GATA6_25053715_ChIP-Seq_YYC3_Human0.83146841
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82901366
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.81892138
86* CJUN_26792858_Chip-Seq_BT549_Human0.81769556
87GATA3_24758297_ChIP-Seq_MCF-7_Human0.81462198
88* ELK3_25401928_ChIP-Seq_HUVEC_Human0.81175232
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81055403
90SRF_21415370_ChIP-Seq_HL-1_Mouse0.80937306
91CHD1_26751641_Chip-Seq_LNCaP_Human0.80353890
92CLOCK_20551151_ChIP-Seq_293T_Human0.79945240
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.77831372
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76002010
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.75877186
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75797906
97FOXO3_23340844_ChIP-Seq_DLD1_Human0.75638505
98MYCN_18555785_ChIP-Seq_MESCs_Mouse0.75398150
99NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74331161
100FOXP3_21729870_ChIP-Seq_TREG_Human0.73758675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology6.67679719
2MP0003806_abnormal_nucleotide_metabolis4.83029130
3MP0010234_abnormal_vibrissa_follicle4.79767193
4MP0003941_abnormal_skin_development4.68673943
5MP0002796_impaired_skin_barrier3.79782438
6MP0000762_abnormal_tongue_morphology3.53824155
7MP0000467_abnormal_esophagus_morphology3.22852103
8MP0001216_abnormal_epidermal_layer3.12626715
9MP0003453_abnormal_keratinocyte_physiol3.00133192
10MP0003566_abnormal_cell_adhesion2.96439503
11MP0003705_abnormal_hypodermis_morpholog2.95551729
12MP0002060_abnormal_skin_morphology2.93046499
13MP0000566_synostosis2.83071228
14MP0002234_abnormal_pharynx_morphology2.78994623
15MP0005501_abnormal_skin_physiology2.71405923
16MP0010678_abnormal_skin_adnexa2.65427908
17MP0009053_abnormal_anal_canal2.63576272
18MP0000678_abnormal_parathyroid_gland2.53024853
19MP0002098_abnormal_vibrissa_morphology2.46855344
20MP0004381_abnormal_hair_follicle2.38877104
21MP0005275_abnormal_skin_tensile2.33909956
22MP0001849_ear_inflammation2.21811509
23MP0005023_abnormal_wound_healing2.18792221
24MP0010771_integument_phenotype2.08796610
25MP0000383_abnormal_hair_follicle2.05345534
26MP0005360_urolithiasis2.02944219
27MP0003950_abnormal_plasma_membrane1.95075703
28MP0005409_darkened_coat_color1.84075431
29MP0000377_abnormal_hair_follicle1.82196294
30MP0003315_abnormal_perineum_morphology1.73195558
31MP0004272_abnormal_basement_membrane1.60132735
32MP0003191_abnormal_cellular_cholesterol1.40679508
33MP0008260_abnormal_autophagy1.39847777
34MP0009379_abnormal_foot_pigmentation1.37304384
35MP0009780_abnormal_chondrocyte_physiolo1.36807962
36MP0004264_abnormal_extraembryonic_tissu1.32059516
37MP0004957_abnormal_blastocyst_morpholog1.31372962
38MP0010030_abnormal_orbit_morphology1.30064760
39MP0009931_abnormal_skin_appearance1.29878165
40MP0010368_abnormal_lymphatic_system1.29166273
41MP0004947_skin_inflammation1.21000064
42MP0000537_abnormal_urethra_morphology1.19559939
43MP0000427_abnormal_hair_cycle1.11852698
44MP0003755_abnormal_palate_morphology1.07868881
45MP0000858_altered_metastatic_potential1.06898811
46MP0001851_eye_inflammation1.02977643
47MP0002877_abnormal_melanocyte_morpholog1.01161353
48MP0000627_abnormal_mammary_gland1.00837111
49MP0008932_abnormal_embryonic_tissue0.97530498
50MP0000367_abnormal_coat/_hair0.97162586
51MP0009697_abnormal_copulation0.96890477
52MP0001191_abnormal_skin_condition0.92761389
53MP0006054_spinal_hemorrhage0.92760243
54MP0008007_abnormal_cellular_replicative0.92586063
55MP0004782_abnormal_surfactant_physiolog0.87889592
56MP0002938_white_spotting0.87459222
57MP0002177_abnormal_outer_ear0.86973461
58MP0003718_maternal_effect0.86828169
59MP0008789_abnormal_olfactory_epithelium0.86556171
60MP0010352_gastrointestinal_tract_polyps0.85860406
61MP0001340_abnormal_eyelid_morphology0.84925711
62MP0003077_abnormal_cell_cycle0.82889783
63MP0003786_premature_aging0.81236468
64MP0001879_abnormal_lymphatic_vessel0.80278455
65MP0000350_abnormal_cell_proliferation0.77996761
66MP0005193_abnormal_anterior_eye0.74558894
67MP0000647_abnormal_sebaceous_gland0.68377444
68MP0000750_abnormal_muscle_regeneration0.66440956
69MP0005257_abnormal_intraocular_pressure0.62279301
70MP0003693_abnormal_embryo_hatching0.61455410
71MP0004134_abnormal_chest_morphology0.61106726
72MP0003186_abnormal_redox_activity0.60762686
73MP0004019_abnormal_vitamin_homeostasis0.59199779
74MP0000358_abnormal_cell_content/0.56622772
75MP0005330_cardiomyopathy0.56570822
76MP0002095_abnormal_skin_pigmentation0.52244138
77MP0002111_abnormal_tail_morphology0.51798596
78MP0001881_abnormal_mammary_gland0.51404312
79MP0002282_abnormal_trachea_morphology0.49113439
80MP0005248_abnormal_Harderian_gland0.47729184
81MP0000013_abnormal_adipose_tissue0.47217052
82MP0001243_abnormal_dermal_layer0.46716235
83MP0005623_abnormal_meninges_morphology0.46025975
84MP0003111_abnormal_nucleus_morphology0.45271234
85MP0005408_hypopigmentation0.45270179
86MP0005164_abnormal_response_to0.45058683
87MP0003123_paternal_imprinting0.44661026
88MP0003638_abnormal_response/metabolism_0.44548483
89MP0003828_pulmonary_edema0.43883848
90MP0005451_abnormal_body_composition0.43727513
91MP0000733_abnormal_muscle_development0.43589836
92MP0005197_abnormal_uvea_morphology0.43500064
93MP0002697_abnormal_eye_size0.42399828
94MP0001661_extended_life_span0.42352730
95MP0002086_abnormal_extraembryonic_tissu0.42201700
96MP0001299_abnormal_eye_distance/0.41819145
97MP0004197_abnormal_fetal_growth/weight/0.41772759
98MP0005395_other_phenotype0.41111062
99MP0005621_abnormal_cell_physiology0.40759229
100MP0003045_fibrosis0.40296005

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)8.82486690
2Onycholysis (HP:0001806)8.51586493
3Fragile nails (HP:0001808)8.11327765
4Plantar hyperkeratosis (HP:0007556)7.68977395
5Abnormality of nail color (HP:0100643)7.61983663
6Thick nail (HP:0001805)6.87698291
7Alopecia of scalp (HP:0002293)6.25532916
8Palmoplantar hyperkeratosis (HP:0000972)5.94593321
9Atrophic scars (HP:0001075)5.84652400
10Nail dystrophy (HP:0008404)5.77120377
11Palmar hyperkeratosis (HP:0010765)5.62479701
12Ridged nail (HP:0001807)5.36325721
13Lip pit (HP:0100267)4.79656073
14Oral leukoplakia (HP:0002745)4.47076899
15Abnormality of placental membranes (HP:0011409)4.39578026
16Amniotic constriction ring (HP:0009775)4.39578026
17Abnormal blistering of the skin (HP:0008066)4.27443150
18Pili torti (HP:0003777)4.22282127
19Right ventricular cardiomyopathy (HP:0011663)3.97233575
20Abnormal hair laboratory examination (HP:0003328)3.87398100
21Hypoplasia of dental enamel (HP:0006297)3.85874971
22Sparse eyelashes (HP:0000653)3.82662556
23Sparse scalp hair (HP:0002209)3.73451868
24Hypotrichosis (HP:0001006)3.51623748
25Oligodontia (HP:0000677)3.46126042
26Popliteal pterygium (HP:0009756)3.38518264
27Natal tooth (HP:0000695)3.31548711
28Pterygium (HP:0001059)3.17038151
29Selective tooth agenesis (HP:0001592)3.16679219
30Congenital ichthyosiform erythroderma (HP:0007431)3.01434528
31Ankyloglossia (HP:0010296)3.00150210
32Aplasia cutis congenita (HP:0001057)2.97244986
33Hypoplastic labia majora (HP:0000059)2.95955122
34Abnormality of secondary sexual hair (HP:0009888)2.95746062
35Abnormality of the axillary hair (HP:0100134)2.95746062
36Dry hair (HP:0011359)2.92175257
37Woolly hair (HP:0002224)2.90482967
38Fragile skin (HP:0001030)2.89858534
39Absent eyelashes (HP:0000561)2.76457462
40Abnormality of the labia majora (HP:0012881)2.68027282
41Fatigable weakness (HP:0003473)2.65198686
42Abnormality of the neuromuscular junction (HP:0003398)2.65198686
43Nasolacrimal duct obstruction (HP:0000579)2.58807290
44Trismus (HP:0000211)2.53166665
45Anonychia (HP:0001798)2.52368198
46Erythema (HP:0010783)2.52340910
47Hyperhidrosis (HP:0000975)2.50501943
48Poikiloderma (HP:0001029)2.47483722
49Abnormality of the salivary glands (HP:0010286)2.47205478
50Palmoplantar keratoderma (HP:0000982)2.45023145
51Carious teeth (HP:0000670)2.44408340
52Xerostomia (HP:0000217)2.36684311
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.36385809
54Erythroderma (HP:0001019)2.33936849
55Corneal erosion (HP:0200020)2.33659241
56Cheilitis (HP:0100825)2.33112643
57Abnormality of oral frenula (HP:0000190)2.31425776
58Stenosis of the external auditory canal (HP:0000402)2.29131200
59Abnormality of cells of the erythroid lineage (HP:0012130)2.28188395
60Advanced eruption of teeth (HP:0006288)2.20427669
61Breast hypoplasia (HP:0003187)2.16791419
62Hypoplasia of the uterus (HP:0000013)2.10938443
63Ectropion (HP:0000656)2.10602553
64Hypodontia (HP:0000668)2.10252188
65Abnormality of the fingernails (HP:0001231)2.08229289
66Abnormalities of placenta or umbilical cord (HP:0001194)2.02683851
67Brittle hair (HP:0002299)1.98782159
68Palpitations (HP:0001962)1.96858619
69Aplasia/hypoplasia of the uterus (HP:0008684)1.90882811
70Abnormality of the lacrimal duct (HP:0011481)1.88236352
71Pustule (HP:0200039)1.85409168
72Absent hair (HP:0002298)1.85405128
73Blepharitis (HP:0000498)1.82390405
74Dehydration (HP:0001944)1.81574605
75Epidermoid cyst (HP:0200040)1.78627513
76Death in infancy (HP:0001522)1.76912544
77Septate vagina (HP:0001153)1.76519711
78Parakeratosis (HP:0001036)1.73454789
79Abnormality of the nasolacrimal system (HP:0000614)1.72158133
80Rough bone trabeculation (HP:0100670)1.71888516
81Periodontitis (HP:0000704)1.71773939
82Multifactorial inheritance (HP:0001426)1.71749724
83Hypoplastic female external genitalia (HP:0012815)1.71537970
84Hoarse voice (HP:0001609)1.68026212
85Hypoplastic pelvis (HP:0008839)1.67501367
86Skin ulcer (HP:0200042)1.65383958
87Abnormality of the renal collecting system (HP:0004742)1.61952384
88Labial hypoplasia (HP:0000066)1.61894607
89Macrocytic anemia (HP:0001972)1.60572049
90Squamous cell carcinoma (HP:0002860)1.60337230
91Laryngomalacia (HP:0001601)1.58603139
92Abnormal number of erythroid precursors (HP:0012131)1.58400372
93Split foot (HP:0001839)1.57213376
94Short nail (HP:0001799)1.54020110
95Acute necrotizing encephalopathy (HP:0006965)1.53086697
96Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.50448960
97Abnormal mitochondria in muscle tissue (HP:0008316)1.49429032
98Reduced subcutaneous adipose tissue (HP:0003758)1.48867134
99Skin pits (HP:0100276)1.47342910
100Axonal loss (HP:0003447)1.45234934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF5.22349410
2MST1R4.62500118
3MET3.57909335
4EPHA23.50875090
5EPHB23.32500248
6PIM23.25658805
7MST42.98647156
8MAP3K122.96258692
9MAP3K92.92344181
10PAK42.39731525
11NME22.36898121
12FLT32.27258714
13STK242.22445051
14NTRK12.20899954
15PTK22.20668656
16RIPK12.14947564
17TGFBR12.13985581
18NEK11.77457019
19PBK1.76530003
20LMTK21.71295044
21BRAF1.70225437
22LATS21.66829701
23STK161.66085524
24BUB11.59303149
25MAP3K21.49586117
26MOS1.48627253
27TLK11.32606743
28ABL21.28121649
29PDGFRA1.24973153
30STK101.22927916
31TGFBR21.22891095
32EIF2AK11.22203207
33ILK1.20274125
34MAP3K31.15368875
35RAF11.11375230
36NME10.98996638
37TESK10.96297736
38IRAK30.95089661
39EIF2AK30.93056047
40SRPK10.92604998
41RPS6KB20.90270145
42PRKCI0.87671634
43MYLK0.80477303
44EPHB10.77581700
45PHKG20.75847199
46PHKG10.75847199
47MAP3K130.71528469
48FER0.70166543
49LATS10.69670469
50AURKB0.68242504
51CDC70.68017576
52BCR0.67896357
53PTK60.67439963
54PAK20.66500029
55AURKA0.64535791
56EIF2AK20.64457820
57BMX0.61441033
58MAP3K80.57924363
59ERBB40.56941829
60BMPR1B0.53381425
61CSNK1G30.52562276
62GRK70.49654347
63ADRBK10.48179008
64MAPKAPK30.48062319
65PRKG20.47938785
66CSNK1A1L0.45769963
67CDK90.45616989
68TTK0.44822951
69MAP3K60.44695902
70CLK10.43186400
71STK30.42920128
72RPS6KL10.42662637
73RPS6KC10.42662637
74MAP2K60.41991480
75PRPF4B0.40445427
76ROCK20.38634370
77AKT20.38071840
78RPS6KA40.37874784
79PAK10.37639377
80PDGFRB0.37282285
81GRK50.37063925
82ZAK0.36500853
83ERBB30.30670712
84TRIB30.30512671
85SIK10.30449612
86PLK10.29442155
87RPS6KA60.29294888
88KSR20.27630738
89VRK10.27010960
90PRKD20.24001246
91PTK2B0.22072783
92STK38L0.21624010
93CSNK1G10.21530419
94LIMK10.21331276
95CCNB10.21005318
96RPS6KA10.20942490
97PRKCD0.20846890
98RPS6KA20.20813065
99DAPK30.20637120
100DMPK0.19485000

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.12304704
2Nucleotide excision repair_Homo sapiens_hsa034203.20138095
3Proteasome_Homo sapiens_hsa030502.93447770
4Mineral absorption_Homo sapiens_hsa049782.83524471
5Oxidative phosphorylation_Homo sapiens_hsa001902.71511309
6Protein export_Homo sapiens_hsa030602.71401202
7Sulfur metabolism_Homo sapiens_hsa009202.54667788
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35369270
9ECM-receptor interaction_Homo sapiens_hsa045122.27550317
10DNA replication_Homo sapiens_hsa030302.17723402
11Mismatch repair_Homo sapiens_hsa034302.08800632
12Parkinsons disease_Homo sapiens_hsa050122.02875092
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.02515081
14p53 signaling pathway_Homo sapiens_hsa041151.93259501
15Steroid biosynthesis_Homo sapiens_hsa001001.91186463
16Alzheimers disease_Homo sapiens_hsa050101.87238379
17Small cell lung cancer_Homo sapiens_hsa052221.81948124
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.78906634
19RNA polymerase_Homo sapiens_hsa030201.77025461
20Pyrimidine metabolism_Homo sapiens_hsa002401.73970404
21Huntingtons disease_Homo sapiens_hsa050161.60854403
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56360364
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54032759
24Shigellosis_Homo sapiens_hsa051311.47427236
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46171296
26Homologous recombination_Homo sapiens_hsa034401.29973203
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.27226669
28Focal adhesion_Homo sapiens_hsa045101.25600680
29Glutathione metabolism_Homo sapiens_hsa004801.23902062
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23126938
31RNA transport_Homo sapiens_hsa030131.16837984
32Salmonella infection_Homo sapiens_hsa051321.16836021
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15973598
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15482581
35Renal cell carcinoma_Homo sapiens_hsa052111.11903841
36Cell cycle_Homo sapiens_hsa041101.06968323
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06770976
38Spliceosome_Homo sapiens_hsa030401.02236737
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00692745
40Base excision repair_Homo sapiens_hsa034100.99964584
41Folate biosynthesis_Homo sapiens_hsa007900.98348539
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96617787
43Circadian rhythm_Homo sapiens_hsa047100.95084652
44One carbon pool by folate_Homo sapiens_hsa006700.94637400
45Adherens junction_Homo sapiens_hsa045200.88984957
46Galactose metabolism_Homo sapiens_hsa000520.88342638
47Basal transcription factors_Homo sapiens_hsa030220.88321040
48Amoebiasis_Homo sapiens_hsa051460.87646679
49Phenylalanine metabolism_Homo sapiens_hsa003600.82599345
50Chemical carcinogenesis_Homo sapiens_hsa052040.81034781
51Proteoglycans in cancer_Homo sapiens_hsa052050.78954270
52Thyroid cancer_Homo sapiens_hsa052160.77648080
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76876904
54ErbB signaling pathway_Homo sapiens_hsa040120.76741633
55Endocytosis_Homo sapiens_hsa041440.71545073
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70428340
57Fanconi anemia pathway_Homo sapiens_hsa034600.68875077
58N-Glycan biosynthesis_Homo sapiens_hsa005100.65428158
59Fructose and mannose metabolism_Homo sapiens_hsa000510.64379990
60Cardiac muscle contraction_Homo sapiens_hsa042600.63532065
61Tyrosine metabolism_Homo sapiens_hsa003500.63400903
62Bladder cancer_Homo sapiens_hsa052190.61728549
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60485907
64Oocyte meiosis_Homo sapiens_hsa041140.58923904
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55932587
66Apoptosis_Homo sapiens_hsa042100.55366649
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54842843
68Pathways in cancer_Homo sapiens_hsa052000.53681258
69VEGF signaling pathway_Homo sapiens_hsa043700.52772895
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51381782
71MicroRNAs in cancer_Homo sapiens_hsa052060.49127479
72Metabolic pathways_Homo sapiens_hsa011000.47080141
73Chronic myeloid leukemia_Homo sapiens_hsa052200.46750457
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46679574
75Pentose phosphate pathway_Homo sapiens_hsa000300.46200249
76Toxoplasmosis_Homo sapiens_hsa051450.45701218
77Hippo signaling pathway_Homo sapiens_hsa043900.45364691
78Purine metabolism_Homo sapiens_hsa002300.45295294
79RNA degradation_Homo sapiens_hsa030180.45036468
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44969143
81Axon guidance_Homo sapiens_hsa043600.43008491
82Pyruvate metabolism_Homo sapiens_hsa006200.42706365
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42261546
84Vitamin B6 metabolism_Homo sapiens_hsa007500.41896154
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39409932
86Arachidonic acid metabolism_Homo sapiens_hsa005900.35466960
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.35041625
88Vibrio cholerae infection_Homo sapiens_hsa051100.34087153
89Fatty acid elongation_Homo sapiens_hsa000620.33670725
90Pancreatic cancer_Homo sapiens_hsa052120.33299683
91Tight junction_Homo sapiens_hsa045300.31963539
92Sphingolipid metabolism_Homo sapiens_hsa006000.31818889
93Systemic lupus erythematosus_Homo sapiens_hsa053220.27786372
94HIF-1 signaling pathway_Homo sapiens_hsa040660.26527346
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24301201
96Dilated cardiomyopathy_Homo sapiens_hsa054140.21256414
97Wnt signaling pathway_Homo sapiens_hsa043100.20399375
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19805261
99TGF-beta signaling pathway_Homo sapiens_hsa043500.19347510
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16891060

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