S100A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.84940179
2adhesion of symbiont to host cell (GO:0044650)8.38031908
3virion attachment to host cell (GO:0019062)8.38031908
4adhesion of symbiont to host (GO:0044406)7.28226581
5peptide cross-linking (GO:0018149)7.25448011
6hair follicle morphogenesis (GO:0031069)7.02982720
7citrulline biosynthetic process (GO:0019240)6.94700490
8establishment of skin barrier (GO:0061436)6.24186661
9cell wall macromolecule catabolic process (GO:0016998)5.71461245
10cell wall macromolecule metabolic process (GO:0044036)5.71461245
11protein maturation by protein folding (GO:0022417)5.69398797
12epidermis development (GO:0008544)5.69223085
13intermediate filament cytoskeleton organization (GO:0045104)5.52841361
14keratinocyte differentiation (GO:0030216)5.41941330
15intermediate filament-based process (GO:0045103)5.40690743
16regulation of water loss via skin (GO:0033561)5.34560453
17membrane raft organization (GO:0031579)5.34328095
18regulation of metalloenzyme activity (GO:0048552)4.91386567
19molting cycle process (GO:0022404)4.84071405
20hair cycle process (GO:0022405)4.84071405
21keratinocyte development (GO:0003334)4.58467895
22bundle of His cell to Purkinje myocyte communication (GO:0086069)4.51005974
23extracellular fibril organization (GO:0043206)4.32178811
24negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.27128594
25nuclear envelope reassembly (GO:0031468)4.24303718
26mitotic nuclear envelope reassembly (GO:0007084)4.24303718
27citrulline metabolic process (GO:0000052)4.23084986
28establishment of viral latency (GO:0019043)4.22154822
29negative regulation of keratinocyte proliferation (GO:0010839)4.15702061
30proteasome assembly (GO:0043248)4.15336128
31hemidesmosome assembly (GO:0031581)4.13156658
32epidermal cell differentiation (GO:0009913)4.12445793
33barbed-end actin filament capping (GO:0051016)4.09270628
34regulation of dendritic cell antigen processing and presentation (GO:0002604)4.02185504
35COPI coating of Golgi vesicle (GO:0048205)4.00579101
36Golgi transport vesicle coating (GO:0048200)4.00579101
37regulation of integrin-mediated signaling pathway (GO:2001044)3.95594111
38positive regulation of actin filament depolymerization (GO:0030836)3.88182652
39establishment of integrated proviral latency (GO:0075713)3.81921412
40fibril organization (GO:0097435)3.81069787
41protein localization to endosome (GO:0036010)3.79287595
42multicellular organismal water homeostasis (GO:0050891)3.76907033
43muscle cell migration (GO:0014812)3.75445016
44negative regulation of nitric oxide biosynthetic process (GO:0045019)3.72229218
45skin morphogenesis (GO:0043589)3.66558775
46type B pancreatic cell proliferation (GO:0044342)3.65569982
47morphogenesis of an endothelium (GO:0003159)3.58110587
48endothelial tube morphogenesis (GO:0061154)3.58110587
49peptidyl-arginine modification (GO:0018195)3.54197460
50positive regulation of monocyte chemotaxis (GO:0090026)3.49900466
51protein retention in ER lumen (GO:0006621)3.47310400
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38432682
53positive regulation of hair cycle (GO:0042635)3.35445171
54positive regulation of hair follicle development (GO:0051798)3.35445171
55hair follicle development (GO:0001942)3.33658892
56cell adhesion mediated by integrin (GO:0033627)3.32972731
57actin filament depolymerization (GO:0030042)3.32804470
58regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.28188433
59negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.27686281
60maturation of 5.8S rRNA (GO:0000460)3.27370324
61endothelial cell morphogenesis (GO:0001886)3.22181871
62pentose-phosphate shunt (GO:0006098)3.17130830
63water homeostasis (GO:0030104)3.15044385
64cranial suture morphogenesis (GO:0060363)3.12504478
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.09812507
66positive regulation of meiotic cell cycle (GO:0051446)3.08803665
67regulation of hair follicle development (GO:0051797)3.07364304
68positive regulation of antigen processing and presentation (GO:0002579)3.05283074
69cellular copper ion homeostasis (GO:0006878)3.05213435
70negative regulation of nitric-oxide synthase activity (GO:0051001)3.03528097
71phosphatidylserine acyl-chain remodeling (GO:0036150)3.03087275
72fibrinolysis (GO:0042730)3.00201058
73hair cycle (GO:0042633)28.9839633
74molting cycle (GO:0042303)28.9839633
75response to gravity (GO:0009629)2.97490623
76epithelium development (GO:0060429)2.97237953
77regulation of keratinocyte differentiation (GO:0045616)2.96795785
78nucleobase-containing small molecule interconversion (GO:0015949)2.95203702
79regulation of mesenchymal cell apoptotic process (GO:2001053)2.94452875
80positive regulation of granulocyte chemotaxis (GO:0071624)2.93879066
81phosphatidylinositol acyl-chain remodeling (GO:0036149)2.93249060
82tooth mineralization (GO:0034505)2.92810631
83glucose catabolic process (GO:0006007)2.92482533
84pinocytosis (GO:0006907)2.89948779
85regulation of membrane protein ectodomain proteolysis (GO:0051043)2.89703051
86skin development (GO:0043588)2.88291314
87lipopolysaccharide biosynthetic process (GO:0009103)2.87903115
88positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.86165244
89bone trabecula formation (GO:0060346)2.85700471
90regulation of antigen processing and presentation (GO:0002577)2.85143497
91positive regulation of pseudopodium assembly (GO:0031274)2.80578113
92NADPH regeneration (GO:0006740)2.78986261
93negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.78746209
94regulation of timing of cell differentiation (GO:0048505)2.77767379
95galactose catabolic process (GO:0019388)2.76149268
96phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.74891361
97positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.72303739
98response to progesterone (GO:0032570)2.71510309
99GDP-mannose metabolic process (GO:0019673)2.70924518
100positive regulation of cellular amide metabolic process (GO:0034250)2.70899933
101polyketide metabolic process (GO:0030638)2.70435638
102doxorubicin metabolic process (GO:0044598)2.70435638
103daunorubicin metabolic process (GO:0044597)2.70435638
104regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.69693263
105epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.69545424
106regulation of T-helper 1 cell differentiation (GO:0045625)2.68870909
107long-chain fatty acid biosynthetic process (GO:0042759)2.68727681
108negative regulation of chondrocyte differentiation (GO:0032331)2.65694143
109protein hydroxylation (GO:0018126)2.65475525
110pyrimidine-containing compound salvage (GO:0008655)2.65288649
111pyrimidine nucleoside salvage (GO:0043097)2.65288649
112positive regulation of Cdc42 GTPase activity (GO:0043089)2.64725864
113wound healing, spreading of epidermal cells (GO:0035313)2.63849147
114embryonic skeletal joint morphogenesis (GO:0060272)2.62687688
115regulation of hair cycle (GO:0042634)2.62152317
116negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.62044352
117mesodermal cell differentiation (GO:0048333)2.62024378
118protein heterotetramerization (GO:0051290)2.61424078
119negative regulation of mitochondrion organization (GO:0010823)2.61309769
120regulation of ruffle assembly (GO:1900027)2.61138732
121substrate-dependent cell migration (GO:0006929)2.60970969
122endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.59543533
123positive regulation of epidermis development (GO:0045684)2.58882939
124negative regulation of stem cell proliferation (GO:2000647)2.57457649
125endosome to melanosome transport (GO:0035646)2.57344908
126endosome to pigment granule transport (GO:0043485)2.57344908
127regulation of development, heterochronic (GO:0040034)2.56365897
128positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.55801224
129phosphatidylcholine acyl-chain remodeling (GO:0036151)2.51596519
130positive regulation of endothelial cell apoptotic process (GO:2000353)2.50539975
131ribosome assembly (GO:0042255)2.49953217
132glomerular visceral epithelial cell development (GO:0072015)2.48867953
133ganglion development (GO:0061548)2.46857509
134regulation of extracellular matrix disassembly (GO:0010715)2.46857409
135membrane assembly (GO:0071709)2.46542953
136negative regulation of response to reactive oxygen species (GO:1901032)2.45960561
137negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.44043749
138regulation of pseudopodium assembly (GO:0031272)2.43472993
139negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.43280750
140fatty acid elongation (GO:0030497)2.42049335
141mesenchymal-epithelial cell signaling (GO:0060638)2.41436993
142response to copper ion (GO:0046688)2.41426006
143negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.38900918
144natural killer cell mediated immunity (GO:0002228)2.38059870
145natural killer cell mediated cytotoxicity (GO:0042267)2.38059870
146regulation of cytokine secretion involved in immune response (GO:0002739)2.37690029
147regulation of epidermal cell differentiation (GO:0045604)2.37416792
148positive regulation of T-helper 1 type immune response (GO:0002827)2.37351739
149pattern specification involved in kidney development (GO:0061004)2.37124867
150cyclooxygenase pathway (GO:0019371)2.35922440
151low-density lipoprotein particle clearance (GO:0034383)2.35921368
152regulation of monocyte chemotaxis (GO:0090025)2.35045784
153regulation of keratinocyte proliferation (GO:0010837)2.32459938
154positive regulation of epidermal cell differentiation (GO:0045606)2.32427676
155craniofacial suture morphogenesis (GO:0097094)2.31688168
156phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.31220733
157gap junction assembly (GO:0016264)2.30862201
158atrioventricular valve morphogenesis (GO:0003181)2.29640012
159limb bud formation (GO:0060174)2.28254306
160response to xenobiotic stimulus (GO:0009410)2.27840253
161eyelid development in camera-type eye (GO:0061029)2.20569748
162regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.20054786
163negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.16048453
164regulation of epidermis development (GO:0045682)2.15840054
165pharyngeal system development (GO:0060037)2.12152145
166dendritic cell chemotaxis (GO:0002407)2.12121788
167cell surface receptor signaling pathway involved in heart development (GO:0061311)2.09429543
168phosphatidylserine metabolic process (GO:0006658)2.08959694
169imidazole-containing compound metabolic process (GO:0052803)2.07110085
170positive regulation of interleukin-1 beta secretion (GO:0050718)2.05742025
171mesenchymal cell differentiation involved in renal system development (GO:2001012)2.05315162
172mesenchymal cell differentiation involved in kidney development (GO:0072161)2.05315162
173cardiovascular system development (GO:0072358)2.04340208
174superoxide anion generation (GO:0042554)2.03756141
175lateral sprouting from an epithelium (GO:0060601)2.03346665
176regulation of granulocyte chemotaxis (GO:0071622)2.01329587
177keratinization (GO:0031424)10.4052236
178intermediate filament organization (GO:0045109)10.2787595
179keratinocyte proliferation (GO:0043616)1.97279708
180lipoxygenase pathway (GO:0019372)1.94968741
181regulation of somitogenesis (GO:0014807)1.94309385
182establishment of tissue polarity (GO:0007164)1.91288686
183establishment of planar polarity (GO:0001736)1.91288686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.37957364
2* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.76954762
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.04917500
4* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.94416326
5P63_26484246_Chip-Seq_KERATINOCYTES_Human2.86738040
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75549666
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.45329239
8ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.32902584
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31627506
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.28010018
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22314896
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.20111797
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20006242
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.19467143
15ZNF263_19887448_ChIP-Seq_K562_Human2.17626058
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.06140079
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.03061225
18TP63_17297297_ChIP-ChIP_HaCaT_Human10.4480185
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98690494
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95318233
21* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91525314
22CTCF_20526341_ChIP-Seq_ESCs_Human1.91185128
23RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89533822
24TP53_20018659_ChIP-ChIP_R1E_Mouse1.86397563
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.84889953
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.79968207
27CLOCK_20551151_ChIP-Seq_293T_Human1.78664484
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.78019142
29ATF3_27146783_Chip-Seq_COLON_Human1.77720766
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77611956
31NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.77395488
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76473320
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72666714
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.72393528
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69376586
36AR_21572438_ChIP-Seq_LNCaP_Human1.68727406
37HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.68682591
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64733218
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64411866
40BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.64370943
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60398575
42TP53_18474530_ChIP-ChIP_U2OS_Human1.59530311
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58459450
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57877199
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.57783172
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56506883
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56124841
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55672632
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.54548149
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53606445
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52937708
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.52806388
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51530270
54* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49798327
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.48306195
56CSB_26484114_Chip-Seq_FIBROBLAST_Human1.47618934
57* RACK7_27058665_Chip-Seq_MCF-7_Human1.46717945
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46576069
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45073969
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44877986
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44877986
62EGR1_19032775_ChIP-ChIP_M12_Human1.44789579
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.44092624
64DCP1A_22483619_ChIP-Seq_HELA_Human1.43799129
65MYC_18555785_ChIP-Seq_MESCs_Mouse1.43183992
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.42670682
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.42666704
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41894542
69* LXR_22292898_ChIP-Seq_THP-1_Human1.41072912
70* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40911276
71TAF2_19829295_ChIP-Seq_ESCs_Human1.40518696
72ERG_20517297_ChIP-Seq_VCAP_Human1.40474081
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.39455605
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38776399
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38653952
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36574086
77* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36066232
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35884836
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35884836
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35384617
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34848319
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34544118
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34205517
84NANOG_20526341_ChIP-Seq_ESCs_Human1.34188211
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.32546931
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28012549
87MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.27361034
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26868199
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25673559
90P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.24722998
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24546024
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23999204
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.23996389
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.23589425
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23440806
96SRF_21415370_ChIP-Seq_HL-1_Mouse1.22855172
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.22806896
98TFEB_21752829_ChIP-Seq_HELA_Human1.22355246
99ETS1_20019798_ChIP-Seq_JURKAT_Human1.21747614
100AHR_22903824_ChIP-Seq_MCF-7_Human1.21619211
101VDR_22108803_ChIP-Seq_LS180_Human1.20559230
102P53_21459846_ChIP-Seq_SAOS-2_Human1.19386197
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17625039
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17623186
105MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17529414
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17064181
107BRD4_25478319_ChIP-Seq_HGPS_Human1.16596286
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14879920
109FLI1_27457419_Chip-Seq_LIVER_Mouse1.13255203
110KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13119197
111* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12939196
112CTCF_27219007_Chip-Seq_Bcells_Human1.12868028
113NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12564226
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11643325
115THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11147679
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10132682
117TET1_21451524_ChIP-Seq_MESCs_Mouse1.09837867
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09726578
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09643984
120* SOX2_20726797_ChIP-Seq_SW620_Human1.08246480
121CEBPB_22108803_ChIP-Seq_LS180_Human1.07939451
122STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05661605
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.04731010
124AR_21909140_ChIP-Seq_LNCAP_Human1.04536047
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04162125
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04089205
127CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03814022
128ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03646796
129E2F1_20622854_ChIP-Seq_HELA_Human1.03548246
130TP63_23658742_ChIP-Seq_EP156T_Human1.03285417
131CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03210845
132GABP_19822575_ChIP-Seq_HepG2_Human1.01985444
133PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00706142
134ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00607392
135MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99666048
136RNF2_27304074_Chip-Seq_NSC_Mouse0.98730782
137ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98508728
138MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98205150
139RING1B_27294783_Chip-Seq_ESCs_Mouse0.97795628
140* GATA6_21074721_ChIP-Seq_CACO-2_Human0.97487564
141* TP53_22127205_ChIP-Seq_IMR90_Human0.97242350
142EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96967136
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96964142
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.96878931
145TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96824421
146MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96689742
147BCL6_27268052_Chip-Seq_Bcells_Human0.96009509
148PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95977334
149SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95598730
150JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94854823
151E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94611214
152BCAT_22108803_ChIP-Seq_LS180_Human0.94405315
153ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94393621
154* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93967925
155SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93667878
156CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92857315
157CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92727617
158NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92514342
159PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92443142
160GBX2_23144817_ChIP-Seq_PC3_Human0.92324483
161ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91330322
162NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90740534
163CJUN_26792858_Chip-Seq_BT549_Human0.89922436
164ELF1_20517297_ChIP-Seq_JURKAT_Human0.89839196
165NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89685831
166SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89206644
167THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89051390
168CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88765474
169EZH2_27294783_Chip-Seq_NPCs_Mouse0.88391727
170SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87986144
171VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87858043
172GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87615454
173SMAD_19615063_ChIP-ChIP_OVARY_Human0.87008012
174NFE2_27457419_Chip-Seq_LIVER_Mouse0.86828370
175GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86092385
176MYC_19829295_ChIP-Seq_ESCs_Human0.86069619
177POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85347863
178TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85347863
179CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85222304
180JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84842205
181* RBPJ_21746931_ChIP-Seq_IB4_Human0.84152961
182FOXA1_25329375_ChIP-Seq_VCAP_Human0.84100280
183FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84100280
184GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.83934626
185GATA3_21867929_ChIP-Seq_TH1_Mouse0.83823113
186RXR_22108803_ChIP-Seq_LS180_Human0.82636859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.10771709
2MP0002098_abnormal_vibrissa_morphology6.50053320
3MP0000647_abnormal_sebaceous_gland5.96737855
4MP0002796_impaired_skin_barrier5.35121290
5MP0002254_reproductive_system_inflammat4.80869368
6MP0005275_abnormal_skin_tensile4.79060291
7MP0000383_abnormal_hair_follicle4.73191276
8MP0010678_abnormal_skin_adnexa3.76948918
9MP0000377_abnormal_hair_follicle3.58141557
10MP0000427_abnormal_hair_cycle3.48388569
11MP0004272_abnormal_basement_membrane3.41229254
12MP0005501_abnormal_skin_physiology3.33233897
13MP0005257_abnormal_intraocular_pressure2.97947272
14MP0003191_abnormal_cellular_cholesterol2.93835013
15MP0006054_spinal_hemorrhage2.91055844
16MP0010234_abnormal_vibrissa_follicle2.88277899
17MP0004381_abnormal_hair_follicle2.76510496
18MP0001216_abnormal_epidermal_layer2.55298719
19MP0000566_synostosis2.25470103
20MP0000367_abnormal_coat/_hair2.22526882
21MP0010771_integument_phenotype2.21640591
22MP0001346_abnormal_lacrimal_gland2.21275537
23MP0005058_abnormal_lysosome_morphology2.19724702
24MP0005023_abnormal_wound_healing2.14058839
25MP0003941_abnormal_skin_development2.10973868
26MP0002332_abnormal_exercise_endurance2.10228332
27MP0002060_abnormal_skin_morphology2.06677948
28MP0009840_abnormal_foam_cell2.01148096
29MP0003806_abnormal_nucleotide_metabolis1.98020025
30MP0001243_abnormal_dermal_layer1.96005248
31MP0010368_abnormal_lymphatic_system1.94037587
32MP0003279_aneurysm1.93989411
33MP0000750_abnormal_muscle_regeneration1.93240969
34MP0001853_heart_inflammation1.91669101
35MP0005165_increased_susceptibility_to1.88753266
36MP0004947_skin_inflammation1.83693605
37MP0003453_abnormal_keratinocyte_physiol1.80270515
38MP0000762_abnormal_tongue_morphology1.73276287
39MP0003075_altered_response_to1.71880840
40MP0003705_abnormal_hypodermis_morpholog1.70731531
41MP0000343_altered_response_to1.64222293
42MP0000467_abnormal_esophagus_morphology1.63819652
43MP0002876_abnormal_thyroid_physiology1.62402555
44MP0000858_altered_metastatic_potential1.61018583
45MP0005409_darkened_coat_color1.59568242
46MP0000751_myopathy1.57089528
47MP0000749_muscle_degeneration1.55991880
48MP0005360_urolithiasis1.53645230
49MP0009780_abnormal_chondrocyte_physiolo1.53610048
50MP0002234_abnormal_pharynx_morphology1.51302948
51MP0001958_emphysema1.44665731
52MP0003091_abnormal_cell_migration1.39215196
53MP0009931_abnormal_skin_appearance1.38453946
54MP0005645_abnormal_hypothalamus_physiol1.32418174
55MP0001879_abnormal_lymphatic_vessel1.26526490
56MP0002877_abnormal_melanocyte_morpholog1.23483984
57MP0003123_paternal_imprinting1.22031263
58MP0008260_abnormal_autophagy1.20666200
59MP0005164_abnormal_response_to1.19216098
60MP0005330_cardiomyopathy1.16084051
61MP0002095_abnormal_skin_pigmentation1.13205877
62MP0000685_abnormal_immune_system1.11520031
63MP0003186_abnormal_redox_activity1.09253472
64MP0002295_abnormal_pulmonary_circulatio1.07089008
65MP0005197_abnormal_uvea_morphology1.05073391
66MP0000767_abnormal_smooth_muscle1.04093475
67MP0004858_abnormal_nervous_system1.01854351
68MP0001849_ear_inflammation1.00701339
69MP0001191_abnormal_skin_condition0.97307644
70MP0003755_abnormal_palate_morphology0.96934861
71MP0005623_abnormal_meninges_morphology0.94474445
72MP0002249_abnormal_larynx_morphology0.93606030
73MP0005171_absent_coat_pigmentation0.93045309
74MP0001348_abnormal_lacrimal_gland0.92886177
75MP0000733_abnormal_muscle_development0.91811521
76MP0003448_altered_tumor_morphology0.91658608
77MP0006082_CNS_inflammation0.90684810
78MP0002896_abnormal_bone_mineralization0.90398711
79MP0008775_abnormal_heart_ventricle0.90100992
80MP0000358_abnormal_cell_content/0.88133442
81MP0001533_abnormal_skeleton_physiology0.86925048
82MP0005503_abnormal_tendon_morphology0.86645775
83MP0001188_hyperpigmentation0.85763497
84MP0001299_abnormal_eye_distance/0.84795856
85MP0002282_abnormal_trachea_morphology0.84450691
86MP0009053_abnormal_anal_canal0.84397050
87MP0005451_abnormal_body_composition0.84245358
88MP0001851_eye_inflammation0.81332822
89MP0003436_decreased_susceptibility_to0.80841353
90MP0005390_skeleton_phenotype0.76529505
91MP0005166_decreased_susceptibility_to0.76442248
92MP0005595_abnormal_vascular_smooth0.76387722
93MP0003566_abnormal_cell_adhesion0.76367310
94MP0003300_gastrointestinal_ulcer0.74041863
95MP0003315_abnormal_perineum_morphology0.73303767
96MP0010030_abnormal_orbit_morphology0.73123238
97MP0003828_pulmonary_edema0.72767347
98MP0008007_abnormal_cellular_replicative0.72399271
99MP0001835_abnormal_antigen_presentation0.71574306
100MP0005310_abnormal_salivary_gland0.70840013
101MP0004742_abnormal_vestibular_system0.67921525
102MP0001542_abnormal_bone_strength0.67739169
103MP0000759_abnormal_skeletal_muscle0.67200731
104MP0002735_abnormal_chemical_nociception0.66347376
105MP0009333_abnormal_splenocyte_physiolog0.66332314
106MP0009785_altered_susceptibility_to0.65743135
107MP0004233_abnormal_muscle_weight0.64924975
108MP0005193_abnormal_anterior_eye0.64754981
109MP0002998_abnormal_bone_remodeling0.64629737
110MP0003303_peritoneal_inflammation0.64449158
111MP0001915_intracranial_hemorrhage0.64043001
112MP0002177_abnormal_outer_ear0.63610014
113MP0003011_delayed_dark_adaptation0.60169733
114MP0000049_abnormal_middle_ear0.59897589
115MP0003786_premature_aging0.59289307
116MP0002972_abnormal_cardiac_muscle0.56980975
117MP0010352_gastrointestinal_tract_polyps0.56432095
118MP0009379_abnormal_foot_pigmentation0.55436944
119MP0001340_abnormal_eyelid_morphology0.54092879
120MP0003136_yellow_coat_color0.54037168
121MP0000678_abnormal_parathyroid_gland0.53579356
122MP0003763_abnormal_thymus_physiology0.52919335
123MP0005075_abnormal_melanosome_morpholog0.52102275
124MP0002148_abnormal_hypersensitivity_rea0.51110411
125MP0002111_abnormal_tail_morphology0.50716554
126MP0000538_abnormal_urinary_bladder0.46777303
127MP0004885_abnormal_endolymph0.46634208
128MP0002109_abnormal_limb_morphology0.45557128
129MP0000613_abnormal_salivary_gland0.44574998
130MP0000627_abnormal_mammary_gland0.44478889
131MP0000516_abnormal_urinary_system0.42684724
132MP0005367_renal/urinary_system_phenotyp0.42684724
133MP0000026_abnormal_inner_ear0.42653734
134MP0002233_abnormal_nose_morphology0.40772037
135MP0003950_abnormal_plasma_membrane0.39927531
136MP0001270_distended_abdomen0.39739746
137MP0003385_abnormal_body_wall0.39058073
138MP0002638_abnormal_pupillary_reflex0.37996691
139MP0003938_abnormal_ear_development0.36124343
140MP0005508_abnormal_skeleton_morphology0.35913649
141MP0000432_abnormal_head_morphology0.35531930
142MP0000372_irregular_coat_pigmentation0.33379043
143MP0003638_abnormal_response/metabolism_0.33150685
144MP0000163_abnormal_cartilage_morphology0.32653930
145MP0000681_abnormal_thyroid_gland0.32538339
146MP0000470_abnormal_stomach_morphology0.31729656
147MP0002116_abnormal_craniofacial_bone0.31328720
148MP0009250_abnormal_appendicular_skeleto0.31143687
149MP0003937_abnormal_limbs/digits/tail_de0.29426749
150MP0004264_abnormal_extraembryonic_tissu0.29407315
151MP0001784_abnormal_fluid_regulation0.29183355
152MP0002970_abnormal_white_adipose0.28447205
153MP0001440_abnormal_grooming_behavior0.27487047
154MP0002115_abnormal_skeleton_extremities0.27439183
155MP0004782_abnormal_surfactant_physiolog0.27322376
156MP0004510_myositis0.27194151
157MP0008438_abnormal_cutaneous_collagen0.26544918
158MP0003935_abnormal_craniofacial_develop0.25502594
159MP0002733_abnormal_thermal_nociception0.24531425
160MP0004270_analgesia0.22659118
161MP0005671_abnormal_response_to0.22356218

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of hair growth rate (HP:0011363)9.78064913
2Slow-growing hair (HP:0002217)9.78064913
3Woolly hair (HP:0002224)9.62629538
4Brittle hair (HP:0002299)8.46559857
5Pili torti (HP:0003777)7.45847872
6Nail dystrophy (HP:0008404)6.43505931
7Premature rupture of membranes (HP:0001788)5.58843583
8Abnormality of nail color (HP:0100643)5.53861761
9Fragile nails (HP:0001808)5.29545084
10Onycholysis (HP:0001806)4.92853165
11Fine hair (HP:0002213)4.61683785
12Palmoplantar hyperkeratosis (HP:0000972)4.48398961
13Abnormal hair laboratory examination (HP:0003328)4.43925278
14Increased IgE level (HP:0003212)4.43589050
15Plantar hyperkeratosis (HP:0007556)4.27472414
16Palmar hyperkeratosis (HP:0010765)4.26432774
17Thick nail (HP:0001805)4.24560604
18Alopecia of scalp (HP:0002293)4.20862393
19Follicular hyperkeratosis (HP:0007502)4.07154190
20Reduced subcutaneous adipose tissue (HP:0003758)4.01233954
21Amelogenesis imperfecta (HP:0000705)3.87452670
22Osteolytic defects of the phalanges of the hand (HP:0009771)3.74667698
23Osteolytic defects of the hand bones (HP:0009699)3.74667698
24Vertebral compression fractures (HP:0002953)3.73858431
25Erythema (HP:0010783)3.67914788
26Sparse eyelashes (HP:0000653)3.66635831
27Right ventricular cardiomyopathy (HP:0011663)3.53230327
28Parakeratosis (HP:0001036)3.49510030
29Congenital, generalized hypertrichosis (HP:0004540)3.49080104
30Short nail (HP:0001799)3.36565385
31Protrusio acetabuli (HP:0003179)3.25345915
32Abnormality of the frontal sinuses (HP:0002687)3.19803751
33Glucose intolerance (HP:0000833)3.14577920
34Aplasia cutis congenita (HP:0001057)3.12119264
35Erythroderma (HP:0001019)3.06389274
36Oral leukoplakia (HP:0002745)3.01862914
37Congenital ichthyosiform erythroderma (HP:0007431)2.97521279
38Milia (HP:0001056)2.97244944
39Abnormality of glycolipid metabolism (HP:0010969)2.92897157
40Abnormality of liposaccharide metabolism (HP:0010968)2.92897157
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.92897157
42Increased connective tissue (HP:0009025)2.87746366
43Curly hair (HP:0002212)2.87344137
44Amyloidosis (HP:0011034)2.82288649
45Dry hair (HP:0011359)2.80328866
46Axonal loss (HP:0003447)2.74346960
47Ridged nail (HP:0001807)2.74308715
48Rough bone trabeculation (HP:0100670)2.69882151
49Keratoconjunctivitis (HP:0001096)2.67299494
50Abnormality of the distal phalanges of the toes (HP:0010182)2.66453281
51Prolonged neonatal jaundice (HP:0006579)2.66383237
52Distal lower limb amyotrophy (HP:0008944)2.65765560
53Entropion (HP:0000621)2.63988020
54Achilles tendon contracture (HP:0001771)2.62555953
55Cervical subluxation (HP:0003308)2.54971839
56Congenital malformation of the right heart (HP:0011723)2.53073955
57Double outlet right ventricle (HP:0001719)2.53073955
58Natal tooth (HP:0000695)2.50460745
59Spinal rigidity (HP:0003306)2.50172306
60Abnormality of the neuromuscular junction (HP:0003398)2.46056888
61Fatigable weakness (HP:0003473)2.46056888
62Microglossia (HP:0000171)2.41841669
63Abnormality of molar morphology (HP:0011070)2.39051286
64Abnormality of molar (HP:0011077)2.39051286
65Abnormality of permanent molar morphology (HP:0011071)2.38132211
66Abnormality of the dental root (HP:0006486)2.38132211
67Taurodontia (HP:0000679)2.38132211
68Adrenal hypoplasia (HP:0000835)2.35166495
69Hypohidrosis (HP:0000966)2.35020578
70Lip pit (HP:0100267)2.33311512
71Joint stiffness (HP:0001387)2.28695672
72Abnormality of the Achilles tendon (HP:0005109)2.28457318
73Fragile skin (HP:0001030)2.28412863
74Abnormality of dental color (HP:0011073)2.27861178
75Nuclear cataract (HP:0100018)2.27312843
76Elbow flexion contracture (HP:0002987)2.26626833
77Acanthosis nigricans (HP:0000956)2.24552615
78Wormian bones (HP:0002645)2.23781321
79Cardiovascular calcification (HP:0011915)2.21352062
80Corneal erosion (HP:0200020)2.20508491
81Myocardial infarction (HP:0001658)2.19591965
82Increased serum pyruvate (HP:0003542)2.18596542
83Abnormal blistering of the skin (HP:0008066)2.17909938
84Abnormality of placental membranes (HP:0011409)2.16864110
85Amniotic constriction ring (HP:0009775)2.16864110
86Generalized amyotrophy (HP:0003700)2.14285793
87Abnormality of the pupil (HP:0000615)2.14243194
88Abnormality of glycolysis (HP:0004366)2.14115868
89Difficulty climbing stairs (HP:0003551)2.13983134
90Abnormal gallbladder physiology (HP:0012438)2.13913071
91Cholecystitis (HP:0001082)2.13913071
92Abnormal trabecular bone morphology (HP:0100671)2.13680443
93Pruritus (HP:0000989)2.11167628
94Vascular calcification (HP:0004934)2.10924178
95Neck muscle weakness (HP:0000467)2.09559758
96Distal upper limb amyotrophy (HP:0007149)2.09212152
97Upper limb amyotrophy (HP:0009129)2.09212152
98Ankle contracture (HP:0006466)2.08059351
99Abnormality of the dental pulp (HP:0006479)2.05264140
100Limb-girdle muscle atrophy (HP:0003797)2.05192664
101Concave nail (HP:0001598)2.04957214
102Abnormality of secondary sexual hair (HP:0009888)2.04947929
103Abnormality of the axillary hair (HP:0100134)2.04947929
104Trismus (HP:0000211)2.01384302
105Hypotrichosis (HP:0001006)12.6782226
106Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98974805
107Advanced eruption of teeth (HP:0006288)1.98469672
108Dysostosis multiplex (HP:0000943)1.97441685
109Abnormal glucose tolerance (HP:0001952)1.96858460
110Aortic dissection (HP:0002647)1.95835819
111Abnormalities of placenta or umbilical cord (HP:0001194)1.95453908
112Abnormality of the parietal bone (HP:0002696)1.93729902
113Vacuolated lymphocytes (HP:0001922)1.93404012
114Keratoconjunctivitis sicca (HP:0001097)1.89710523
115Blue sclerae (HP:0000592)1.88528055
116Hand muscle atrophy (HP:0009130)1.88135111
117Abnormality of the umbilical cord (HP:0010881)1.85235378
118Unilateral renal agenesis (HP:0000122)1.83653295
119Aplasia/Hypoplasia of the spleen (HP:0010451)1.82928941
120Recurrent corneal erosions (HP:0000495)1.82115867
121Neurofibrillary tangles (HP:0002185)1.82068792
122Palmoplantar keratoderma (HP:0000982)1.78046904
123Aortic aneurysm (HP:0004942)1.76414406
124Epiphyseal dysplasia (HP:0002656)1.75984345
125Short clavicles (HP:0000894)1.74589274
126Abnormality of the aortic arch (HP:0012303)1.74107313
127Lower limb amyotrophy (HP:0007210)1.74073976
128Cerebral aneurysm (HP:0004944)1.73590799
129Insulin resistance (HP:0000855)1.73470979
130Hepatosplenomegaly (HP:0001433)1.73377804
131Distal lower limb muscle weakness (HP:0009053)1.73278465
132Bladder diverticulum (HP:0000015)1.72879536
133Ectropion (HP:0000656)1.72793553
134Multiple lipomas (HP:0001012)1.72055624
135Bifid uvula (HP:0000193)1.69180434
136Irregular epiphyses (HP:0010582)1.67879009
137Absent eyelashes (HP:0000561)1.67435399
138Hypergammaglobulinemia (HP:0010702)1.65102709
139Autoamputation (HP:0001218)1.64861699
140Ventricular tachycardia (HP:0004756)1.64520044
141Gangrene (HP:0100758)1.60643875
142Difficulty walking (HP:0002355)1.59183371
143Widely patent fontanelles and sutures (HP:0004492)1.57069851
144Corneal dystrophy (HP:0001131)1.57001452
145Recurrent bacterial skin infections (HP:0005406)1.55417562
146Abnormality of incisor morphology (HP:0011063)1.54014194
147Eczematoid dermatitis (HP:0000976)1.53996959
148Blepharitis (HP:0000498)1.52974468
149Upper limb muscle weakness (HP:0003484)1.52203167
150Sparse scalp hair (HP:0002209)1.47589601
151Torticollis (HP:0000473)1.47086730
152Craniofacial hyperostosis (HP:0004493)1.46313900
153Neonatal short-limb short stature (HP:0008921)1.45417031
154Absent hair (HP:0002298)1.45138647
155Heterogeneous (HP:0001425)1.44716595
156Abnormality of the fingernails (HP:0001231)1.42177486
157Carious teeth (HP:0000670)1.41285651
158Xerostomia (HP:0000217)1.36652732
159Asplenia (HP:0001746)1.35888618
160Abnormality of the preputium (HP:0100587)1.34434220
161Vitreoretinal degeneration (HP:0000655)1.32799261
162Widely spaced teeth (HP:0000687)1.30503197
163Hypoplasia of dental enamel (HP:0006297)1.30178143
164Atrophic scars (HP:0001075)1.29978280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.43270003
2MST1R5.15110382
3TESK14.61084672
4EPHA23.58475202
5MUSK3.27529837
6ERBB33.24344623
7IRAK43.09420887
8NME12.95395796
9BCR2.93457959
10TESK22.88637376
11CASK2.85459237
12VRK22.74926509
13FER2.65680080
14ARAF2.58863154
15MET2.51174437
16BMPR22.43045082
17MAP3K122.38831797
18MAPKAPK32.37498005
19PAK42.31370285
20MAP3K142.25199939
21LMTK22.22260758
22EPHB22.18464319
23TRPM72.08530738
24MYLK2.01376714
25ERN12.01188227
26STK38L1.99039839
27TNIK1.97976294
28MAP3K31.90852884
29MAP3K61.90455359
30IRAK31.90114189
31PIM21.87770393
32MOS1.86141394
33ABL21.79270307
34PIK3CG1.78488425
35ZAK1.78098604
36IRAK11.62136071
37NLK1.58904596
38STK241.54526051
39MAP2K61.54095317
40MKNK11.52802730
41TAOK21.48202512
42PTK21.46157105
43EPHA31.43450767
44SIK31.43300979
45CLK11.39725899
46PBK1.36513263
47DYRK1B1.36078510
48MKNK21.33425802
49TGFBR21.32444840
50ILK1.28795845
51BMX1.26296682
52RPS6KB21.25666534
53STK101.23101204
54MST41.19077446
55DAPK11.16356755
56STK161.10840483
57OBSCN1.06333758
58KDR1.03803499
59PLK21.03618497
60BMPR1B1.02099143
61IRAK21.01907739
62EIF2AK10.99895132
63CDK80.98222083
64DDR20.96132222
65TTN0.94436239
66PRKCI0.94389863
67PDGFRA0.93257519
68EPHB10.90879220
69IKBKE0.90675298
70NEK10.90159626
71MAPK130.88699314
72MAPKAPK50.86415418
73GRK10.84632792
74BLK0.84566005
75EIF2AK20.83801268
76BRAF0.83351612
77CDK30.83186838
78ADRBK20.82440702
79BCKDK0.78564856
80SRPK10.77488734
81PHKG20.77008036
82PHKG10.77008036
83SIK10.74550929
84RIPK10.73367987
85LATS20.72539451
86DAPK30.72234322
87INSRR0.71011148
88AKT30.70271196
89YES10.69086180
90DYRK20.68959893
91MAPKAPK20.68536612
92NTRK20.66696457
93IKBKB0.66269340
94PDK20.65195764
95TXK0.65163252
96DYRK30.65004326
97PRKCE0.63634294
98PAK10.63594871
99LRRK20.62363937
100PTK2B0.59609875
101PKN10.59448540
102CHUK0.59332807
103CCNB10.59163329
104TNK20.57062495
105PINK10.57012923
106ICK0.56593086
107BUB10.56546824
108NEK90.55968991
109BRSK10.55659528
110NEK60.50320589
111SCYL20.49200468
112LATS10.47705185
113AURKA0.47483554
114ROCK20.46080602
115EIF2AK30.45543996
116MAP2K30.45389690
117NTRK10.45337124
118MAP3K80.45295616
119PRKACA0.44736525
120GRK70.44731363
121CSNK1A10.42092018
122CAMK2G0.41596039
123FLT30.41499439
124TSSK60.41452875
125CDC42BPA0.40816376
126GSK3A0.40115706
127DYRK1A0.39837949
128MAP3K50.39365149
129GRK50.38741416
130ROCK10.37788572
131PAK20.37643928
132PLK40.37075675
133CSNK1G30.36686995
134CSNK1A1L0.35819735
135ADRBK10.35754412
136MAP3K110.35378792
137SGK10.34223177
138LIMK10.32593880
139PRKG20.31761946
140SMG10.31688211
141MAP2K70.31285436
142PRKAA20.30258464
143MAP3K20.27881847
144MELK0.27801266
145VRK10.27528286
146SYK0.27478362
147CDK70.27194639
148MAPK70.26693035
149TBK10.25937481
150PRKCD0.25911513
151PRKCA0.25810589
152MAP2K10.25303714
153CDK140.25079523
154TIE10.25077556
155PRPF4B0.23726761
156PRKD20.23691792
157TYK20.23584126
158EPHA40.23255724
159PRKCQ0.23250619
160AURKB0.22645573
161CDK180.22603346
162ERBB40.22476201
163CDK11A0.21880494
164TRIB30.21653145
165CDK150.21617653
166CAMK2A0.20751245
167PTK60.20101636

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005914.00882447
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.82176707
3Fatty acid elongation_Homo sapiens_hsa000623.27250868
4Arachidonic acid metabolism_Homo sapiens_hsa005902.95285314
5Ether lipid metabolism_Homo sapiens_hsa005652.92077098
6Galactose metabolism_Homo sapiens_hsa000522.45296947
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.28615031
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.28123289
9Pentose phosphate pathway_Homo sapiens_hsa000302.25566848
10Other glycan degradation_Homo sapiens_hsa005112.20274517
11Glutathione metabolism_Homo sapiens_hsa004802.19114300
12Sulfur relay system_Homo sapiens_hsa041222.18096482
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.12081155
14Proteasome_Homo sapiens_hsa030502.11420944
15Folate biosynthesis_Homo sapiens_hsa007902.06657086
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95811997
17Fructose and mannose metabolism_Homo sapiens_hsa000511.86682384
18Sphingolipid metabolism_Homo sapiens_hsa006001.84467877
19Asthma_Homo sapiens_hsa053101.83710598
20Shigellosis_Homo sapiens_hsa051311.78160732
21Sulfur metabolism_Homo sapiens_hsa009201.76694484
22Basal cell carcinoma_Homo sapiens_hsa052171.75159895
23Lysosome_Homo sapiens_hsa041421.74176674
24DNA replication_Homo sapiens_hsa030301.67115517
25Histidine metabolism_Homo sapiens_hsa003401.66960236
26Pyrimidine metabolism_Homo sapiens_hsa002401.65294012
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61238336
28Phototransduction_Homo sapiens_hsa047441.50311753
29ECM-receptor interaction_Homo sapiens_hsa045121.48595908
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47568283
31Axon guidance_Homo sapiens_hsa043601.47502360
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47007134
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43760856
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43619694
35Phenylalanine metabolism_Homo sapiens_hsa003601.43078915
36Biosynthesis of amino acids_Homo sapiens_hsa012301.38928664
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.38316842
38N-Glycan biosynthesis_Homo sapiens_hsa005101.37165023
39Salmonella infection_Homo sapiens_hsa051321.33996390
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31489723
41Focal adhesion_Homo sapiens_hsa045101.31201236
42Protein export_Homo sapiens_hsa030601.31013119
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.25330800
44Steroid biosynthesis_Homo sapiens_hsa001001.24231669
45Carbon metabolism_Homo sapiens_hsa012001.23622314
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23573718
47Nucleotide excision repair_Homo sapiens_hsa034201.21992344
48Autoimmune thyroid disease_Homo sapiens_hsa053201.21205047
49Non-homologous end-joining_Homo sapiens_hsa034501.20561744
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20309838
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19978684
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17739061
53p53 signaling pathway_Homo sapiens_hsa041151.17660662
54Parkinsons disease_Homo sapiens_hsa050121.14189113
55Base excision repair_Homo sapiens_hsa034101.14021578
56Pyruvate metabolism_Homo sapiens_hsa006201.12939415
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11699643
58Hedgehog signaling pathway_Homo sapiens_hsa043401.11642775
59Central carbon metabolism in cancer_Homo sapiens_hsa052301.10297704
60Rheumatoid arthritis_Homo sapiens_hsa053231.08318442
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06788679
62SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05949923
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04834032
64Allograft rejection_Homo sapiens_hsa053301.04571180
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04049446
66Huntingtons disease_Homo sapiens_hsa050161.03439097
67Serotonergic synapse_Homo sapiens_hsa047261.03145244
68Melanoma_Homo sapiens_hsa052181.02115358
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99643153
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96789373
71Ribosome_Homo sapiens_hsa030100.96672010
72Pertussis_Homo sapiens_hsa051330.93573090
73Endocytosis_Homo sapiens_hsa041440.93153213
74Melanogenesis_Homo sapiens_hsa049160.92969703
75Olfactory transduction_Homo sapiens_hsa047400.92656545
76Mismatch repair_Homo sapiens_hsa034300.92295828
77Vitamin digestion and absorption_Homo sapiens_hsa049770.92184009
78Phagosome_Homo sapiens_hsa041450.86615523
79Graft-versus-host disease_Homo sapiens_hsa053320.86487795
80Ras signaling pathway_Homo sapiens_hsa040140.86289964
81Hippo signaling pathway_Homo sapiens_hsa043900.83444719
82Long-term depression_Homo sapiens_hsa047300.83137182
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83081020
84Primary immunodeficiency_Homo sapiens_hsa053400.82862693
85Nicotine addiction_Homo sapiens_hsa050330.80161207
86Small cell lung cancer_Homo sapiens_hsa052220.79871234
87TNF signaling pathway_Homo sapiens_hsa046680.79265493
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77381663
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76821624
90Fatty acid biosynthesis_Homo sapiens_hsa000610.73856246
91TGF-beta signaling pathway_Homo sapiens_hsa043500.73661677
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73030197
93Wnt signaling pathway_Homo sapiens_hsa043100.72569888
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72066583
95Mineral absorption_Homo sapiens_hsa049780.70970692
96Oxidative phosphorylation_Homo sapiens_hsa001900.70370490
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.69256964
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68950639
99RNA polymerase_Homo sapiens_hsa030200.68411579
100Malaria_Homo sapiens_hsa051440.68337293
101Fat digestion and absorption_Homo sapiens_hsa049750.67714843
102Prion diseases_Homo sapiens_hsa050200.67585691
103Tuberculosis_Homo sapiens_hsa051520.64624932
104Complement and coagulation cascades_Homo sapiens_hsa046100.64462175
105Leishmaniasis_Homo sapiens_hsa051400.62298598
106Tight junction_Homo sapiens_hsa045300.61494052
107Tyrosine metabolism_Homo sapiens_hsa003500.60759600
108Collecting duct acid secretion_Homo sapiens_hsa049660.60646437
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60222273
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.59992543
111Antigen processing and presentation_Homo sapiens_hsa046120.59392960
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.59072323
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58143712
114Calcium signaling pathway_Homo sapiens_hsa040200.58014896
115Protein digestion and absorption_Homo sapiens_hsa049740.53874109
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53635038
117Ovarian steroidogenesis_Homo sapiens_hsa049130.52712849
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52450656
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.51906556
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51868148
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.51742179
122Alzheimers disease_Homo sapiens_hsa050100.51172502
123GnRH signaling pathway_Homo sapiens_hsa049120.50987051
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.50131015
125Hepatitis C_Homo sapiens_hsa051600.47702681
126HIF-1 signaling pathway_Homo sapiens_hsa040660.46821118
127Apoptosis_Homo sapiens_hsa042100.46739560
128Legionellosis_Homo sapiens_hsa051340.46353779
129Vibrio cholerae infection_Homo sapiens_hsa051100.43024331
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42308232
131Pancreatic cancer_Homo sapiens_hsa052120.41745920
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41637929
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.41443183
134Renin-angiotensin system_Homo sapiens_hsa046140.41255104
135Adherens junction_Homo sapiens_hsa045200.41177590
136African trypanosomiasis_Homo sapiens_hsa051430.39867864
137Epstein-Barr virus infection_Homo sapiens_hsa051690.39466422
138Proteoglycans in cancer_Homo sapiens_hsa052050.39337550
139Pathways in cancer_Homo sapiens_hsa052000.38869505
140Metabolic pathways_Homo sapiens_hsa011000.37985405
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37451648
142Purine metabolism_Homo sapiens_hsa002300.35893578
143MicroRNAs in cancer_Homo sapiens_hsa052060.35341836
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35009696
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.34755972
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34649541
147Amoebiasis_Homo sapiens_hsa051460.34226883
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33898933
149Viral myocarditis_Homo sapiens_hsa054160.33845871
150Bladder cancer_Homo sapiens_hsa052190.33308962
151Dilated cardiomyopathy_Homo sapiens_hsa054140.32719442
152Salivary secretion_Homo sapiens_hsa049700.32258054
153Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32123437
154Rap1 signaling pathway_Homo sapiens_hsa040150.31742594
155Pancreatic secretion_Homo sapiens_hsa049720.31379326
156Toxoplasmosis_Homo sapiens_hsa051450.31194385
157Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30780024

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