S100A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.62444779
2negative regulation of cell killing (GO:0031342)4.62444779
3positive regulation of gamma-delta T cell activation (GO:0046645)4.58929277
4viral transcription (GO:0019083)4.45934986
5mesenchymal-epithelial cell signaling (GO:0060638)4.45894456
6membrane raft organization (GO:0031579)4.45816856
7chondrocyte proliferation (GO:0035988)4.43778030
8translational termination (GO:0006415)4.29701177
9immunoglobulin mediated immune response (GO:0016064)4.28756602
10response to peptidoglycan (GO:0032494)4.12275904
11antigen processing and presentation of endogenous antigen (GO:0019883)4.10526429
12wound healing, spreading of epidermal cells (GO:0035313)4.07830497
13negative regulation of interleukin-12 production (GO:0032695)4.06921254
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.05875008
15regulation of protein heterodimerization activity (GO:0043497)3.98458569
16negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.96857636
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81879071
18cellular response to interferon-alpha (GO:0035457)3.80411096
19myeloid cell homeostasis (GO:0002262)3.79881235
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.78854785
21outer ear morphogenesis (GO:0042473)3.75600484
22wound healing, spreading of cells (GO:0044319)3.74334167
23neutrophil activation involved in immune response (GO:0002283)3.73603271
24protein targeting to ER (GO:0045047)3.72001829
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.69799141
26ribosomal small subunit biogenesis (GO:0042274)3.67971766
27cell adhesion mediated by integrin (GO:0033627)3.66438236
28cotranslational protein targeting to membrane (GO:0006613)3.65597881
29regulation of tight junction assembly (GO:2000810)3.63781245
30translational elongation (GO:0006414)3.59855525
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56790242
32detection of other organism (GO:0098543)3.56660999
33Arp2/3 complex-mediated actin nucleation (GO:0034314)3.56556248
34granulocyte activation (GO:0036230)3.55112432
35regulation of B cell receptor signaling pathway (GO:0050855)3.53159865
36collagen fibril organization (GO:0030199)3.49132531
37neutrophil activation (GO:0042119)3.48517385
38detection of bacterium (GO:0016045)3.48422710
39protein localization to endoplasmic reticulum (GO:0070972)3.46347931
40viral life cycle (GO:0019058)3.45375431
41mature B cell differentiation involved in immune response (GO:0002313)3.45305709
42regulation of T cell tolerance induction (GO:0002664)3.44865754
43positive regulation of natural killer cell differentiation (GO:0032825)3.43183060
44middle ear morphogenesis (GO:0042474)3.42968847
45macrophage activation involved in immune response (GO:0002281)3.42405458
46regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.42273694
47cellular protein complex disassembly (GO:0043624)3.41200313
48sequestering of extracellular ligand from receptor (GO:0035581)3.33726950
49platelet aggregation (GO:0070527)3.32963809
50apoptotic cell clearance (GO:0043277)3.32472168
51leukocyte aggregation (GO:0070486)3.32149956
52respiratory burst (GO:0045730)3.31420367
53cellular response to type I interferon (GO:0071357)3.30416960
54type I interferon signaling pathway (GO:0060337)3.30416960
55regulation of vitamin D biosynthetic process (GO:0060556)3.28966600
56B cell mediated immunity (GO:0019724)3.27715508
57regulation of mast cell degranulation (GO:0043304)3.27485807
58regulation of integrin-mediated signaling pathway (GO:2001044)3.26687679
59endodermal cell differentiation (GO:0035987)3.26078486
60response to type I interferon (GO:0034340)3.24838184
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23619476
62positive regulation of endothelial cell apoptotic process (GO:2000353)3.22467439
63cortical actin cytoskeleton organization (GO:0030866)3.20784562
64negative regulation of nitric oxide biosynthetic process (GO:0045019)3.20369362
65myeloid cell activation involved in immune response (GO:0002275)3.20147322
66regulation of early endosome to late endosome transport (GO:2000641)3.18782430
67nucleobase-containing small molecule interconversion (GO:0015949)3.17811758
68positive regulation of B cell differentiation (GO:0045579)3.17708128
69T cell migration (GO:0072678)3.16229737
70regulation of tolerance induction (GO:0002643)3.13830028
71response to interferon-beta (GO:0035456)3.12647811
72regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.12330438
73regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.12024769
74detection of external biotic stimulus (GO:0098581)3.11663967
75positive regulation of mast cell activation (GO:0033005)3.09688535
76positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.09487241
77regulation of gamma-delta T cell activation (GO:0046643)3.08697964
78dermatan sulfate biosynthetic process (GO:0030208)3.08543488
79nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.07728897
80lipopolysaccharide-mediated signaling pathway (GO:0031663)3.07298569
81interferon-gamma-mediated signaling pathway (GO:0060333)3.07006882
82protein targeting to plasma membrane (GO:0072661)3.06294801
83positive regulation of actin filament depolymerization (GO:0030836)3.03376643
84translational initiation (GO:0006413)3.02708750
85positive regulation of mast cell activation involved in immune response (GO:0033008)3.02593678
86positive regulation of mast cell degranulation (GO:0043306)3.02593678
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00338329
88protein targeting to membrane (GO:0006612)2.99982818
89positive thymic T cell selection (GO:0045059)2.99444175
90regulation of mast cell activation involved in immune response (GO:0033006)2.98599276
91regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.97558712
92regulation of metalloenzyme activity (GO:0048552)2.94650770
93membrane budding (GO:0006900)2.93919579
94skin morphogenesis (GO:0043589)2.93745027
95lymphocyte chemotaxis (GO:0048247)2.93698453
96detection of molecule of bacterial origin (GO:0032490)2.92733770
97positive regulation of monocyte chemotaxis (GO:0090026)2.90607155
98positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90172610
99regulation of T cell mediated cytotoxicity (GO:0001914)2.89084407
100barbed-end actin filament capping (GO:0051016)2.88304963
101NIK/NF-kappaB signaling (GO:0038061)2.87525581
102ribosomal small subunit assembly (GO:0000028)2.87222905
103regulation of mononuclear cell migration (GO:0071675)2.87068434
104protein heterotrimerization (GO:0070208)2.86854558
105regulation of histone phosphorylation (GO:0033127)2.86749223
106regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.85825917
107regulation of myeloid leukocyte mediated immunity (GO:0002886)2.85380623
108regulation of vitamin metabolic process (GO:0030656)2.83648695
109positive regulation of interferon-alpha production (GO:0032727)2.83165385
110natural killer cell mediated cytotoxicity (GO:0042267)2.82153786
111natural killer cell mediated immunity (GO:0002228)2.82153786
112cortical cytoskeleton organization (GO:0030865)2.81583227
113dermatan sulfate metabolic process (GO:0030205)2.80899672
114regulation of mast cell activation (GO:0033003)2.80561452
115regulation of leukocyte degranulation (GO:0043300)2.79827580
116actin filament depolymerization (GO:0030042)2.79253466
117regulation of interferon-beta biosynthetic process (GO:0045357)2.78637988
118negative regulation of leukocyte mediated immunity (GO:0002704)2.78077648
119negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.77883335
120peptidyl-proline hydroxylation (GO:0019511)2.77309799
121cellular extravasation (GO:0045123)2.77256699
122regulation of natural killer cell mediated immunity (GO:0002715)2.76588840
123regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.76588840
124positive regulation of tolerance induction (GO:0002645)2.76544951
125T cell apoptotic process (GO:0070231)2.76520799
126leukocyte degranulation (GO:0043299)2.75779178
127regulation of gamma-delta T cell differentiation (GO:0045586)2.75256114
128antigen processing and presentation via MHC class Ib (GO:0002475)2.74567099
129regulation of antigen processing and presentation (GO:0002577)2.74248067
130negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73933884
131positive regulation of interleukin-8 secretion (GO:2000484)2.72489950
132cytidine deamination (GO:0009972)2.72292777
133cytidine metabolic process (GO:0046087)2.72292777
134cytidine catabolic process (GO:0006216)2.72292777
135negative regulation of cytokine production involved in immune response (GO:0002719)2.71980663
136positive regulation of antigen processing and presentation (GO:0002579)2.71455008
137protein complex disassembly (GO:0043241)2.71075564
138detection of biotic stimulus (GO:0009595)2.70780445
139low-density lipoprotein particle clearance (GO:0034383)2.70240265
140myeloid dendritic cell activation (GO:0001773)2.69578121
141actin nucleation (GO:0045010)2.69391360
142cellular response to arsenic-containing substance (GO:0071243)2.68701355
143negative regulation of lymphocyte mediated immunity (GO:0002707)2.68147793
144negative regulation of innate immune response (GO:0045824)2.67151618
145negative T cell selection (GO:0043383)2.66338301
146modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.66223336
147modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.66223336
148positive regulation by organism of defense response of other organism involved in symbiotic interact2.66223336
149modulation by symbiont of host immune response (GO:0052553)2.66223336
150positive regulation by symbiont of host defense response (GO:0052509)2.66223336
151modulation by symbiont of host defense response (GO:0052031)2.66223336
152maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.66127532
153myeloid dendritic cell differentiation (GO:0043011)2.65316626
154amino sugar catabolic process (GO:0046348)2.64919088
155response to interferon-alpha (GO:0035455)2.64717041
156cellular defense response (GO:0006968)2.64279373
157regulation of interferon-alpha production (GO:0032647)2.63773747
158pinocytosis (GO:0006907)2.63762873
159regulation of membrane protein ectodomain proteolysis (GO:0051043)2.63428693
160negative regulation of glycoprotein metabolic process (GO:1903019)2.62939447
161positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.62684612
162positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.61717453
163microglial cell activation (GO:0001774)2.61471275
164regulation of leukocyte mediated cytotoxicity (GO:0001910)2.60567006
165mast cell activation (GO:0045576)2.60485508
166mature B cell differentiation (GO:0002335)2.59395130
167regulation of B cell differentiation (GO:0045577)2.59350359
168protein retention in ER lumen (GO:0006621)2.59267947
169defense response to protozoan (GO:0042832)2.57287890
170regulation of alpha-beta T cell proliferation (GO:0046640)2.57257919
171regulation of lymphocyte migration (GO:2000401)2.56680592
172DNA deamination (GO:0045006)2.55263000
173embryonic cranial skeleton morphogenesis (GO:0048701)2.55232337
174metanephric mesenchyme development (GO:0072075)2.54023577
175fibril organization (GO:0097435)2.53903986
176myeloid leukocyte activation (GO:0002274)2.53574048
177regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.52123612
178cellular response to vitamin (GO:0071295)2.51928159
179positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.50428261
180regulation of T-helper 1 cell differentiation (GO:0045625)2.49341472
181macromolecular complex disassembly (GO:0032984)2.48646795
182response to laminar fluid shear stress (GO:0034616)2.48461736
183positive regulation of keratinocyte differentiation (GO:0045618)2.43371660
184localization within membrane (GO:0051668)2.43193478
185positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.43137478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.14219490
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.86876244
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.61916587
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse4.03391132
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.73913931
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.15246057
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94515685
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.92205651
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88420374
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.75366303
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.69674426
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.62488981
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58178391
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52490646
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.50971622
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46347745
17CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.45317076
18CLOCK_20551151_ChIP-Seq_293T_Human2.41218461
19* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.38788657
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.31265639
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.21908978
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15351499
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13394031
24* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.08925876
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05335456
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02433461
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.02260281
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.02260281
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98683150
30SPI1_23127762_ChIP-Seq_K562_Human1.96083283
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.95876097
32HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.92912001
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91296758
34RUNX_20019798_ChIP-Seq_JUKART_Human1.88848328
35BRD4_25478319_ChIP-Seq_HGPS_Human1.87206296
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.86442810
37ELK1_22589737_ChIP-Seq_MCF10A_Human1.86393023
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85278950
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.83519643
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.79587257
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.79587257
42CJUN_26792858_Chip-Seq_BT549_Human1.78625727
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77473745
44* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76654035
45* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75853198
46ATF3_27146783_Chip-Seq_COLON_Human1.74352119
47TFEB_21752829_ChIP-Seq_HELA_Human1.73783907
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73732594
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73022947
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71159913
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.66385983
52MAF_26560356_Chip-Seq_TH2_Human1.66385899
53* MYB_26560356_Chip-Seq_TH1_Human1.64903648
54ELK1_19687146_ChIP-ChIP_HELA_Human1.63903424
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62005127
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62003412
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59660175
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57180747
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57074501
60LXR_22292898_ChIP-Seq_THP-1_Human1.51940857
61JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51550614
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47361477
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.46868642
64SMC1_22415368_ChIP-Seq_MEFs_Mouse1.46374515
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44363034
66SCL_19346495_ChIP-Seq_HPC-7_Human1.44216185
67* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42143699
68BCL6_27268052_Chip-Seq_Bcells_Human1.41794807
69* VDR_24763502_ChIP-Seq_THP-1_Human1.39961401
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36579257
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36022170
72DCP1A_22483619_ChIP-Seq_HELA_Human1.35834471
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.35367995
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35099674
75MYC_22102868_ChIP-Seq_BL_Human1.34723668
76* SPI1_23547873_ChIP-Seq_NB4_Human1.34136633
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33739633
78VDR_24787735_ChIP-Seq_THP-1_Human1.31305549
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30712818
80* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30451680
81GATA3_27048872_Chip-Seq_THYMUS_Human1.30025003
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29724429
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28013240
84* UBF1/2_26484160_Chip-Seq_HMECs_Human1.26657699
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26051820
86SOX2_20726797_ChIP-Seq_SW620_Human1.25662075
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24090407
88MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23181619
89BCOR_27268052_Chip-Seq_Bcells_Human1.22907008
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.22368162
91* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22298561
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21779397
93P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21741881
94* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21344927
95* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20910595
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20502891
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20438631
98* MAF_26560356_Chip-Seq_TH1_Human1.19577294
99* RACK7_27058665_Chip-Seq_MCF-7_Human1.16904127
100TP53_22127205_ChIP-Seq_IMR90_Human1.16757859
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16375561
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15389842
103VDR_21846776_ChIP-Seq_THP-1_Human1.15112685
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14630942
105GATA3_26560356_Chip-Seq_TH2_Human1.14259452
106GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13666926
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13142050
108TCF7_22412390_ChIP-Seq_EML_Mouse1.10236719
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09514409
110* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07602133
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06854570
112* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06622046
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06210051
114GATA2_21666600_ChIP-Seq_HMVEC_Human1.06019869
115* GATA1_19941827_ChIP-Seq_MEL_Mouse1.05372782
116KDM2B_26808549_Chip-Seq_DND41_Human1.03972369
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03787362
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03215875
119STAT1_20625510_ChIP-Seq_HELA_Human1.02902883
120* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02212424
121GABP_17652178_ChIP-ChIP_JURKAT_Human1.01486875
122CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01406796
123* RUNX1_22412390_ChIP-Seq_EML_Mouse1.00852202
124* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00751540
125* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99233902
126RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99164252
127* UTX_26944678_Chip-Seq_JUKART_Human0.98732255
128* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97676365
129SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97061329
130* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96645081
131SMAD_19615063_ChIP-ChIP_OVARY_Human0.96235430
132MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96105118
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94710572
134CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94243252
135* MYB_26560356_Chip-Seq_TH2_Human0.94068285
136PU_27001747_Chip-Seq_BMDM_Mouse0.93606152
137XRN2_22483619_ChIP-Seq_HELA_Human0.93311191
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93227967
139SPI1_20517297_ChIP-Seq_HL60_Human0.92584137
140* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92465055
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91927846
142CTCF_26484167_Chip-Seq_Bcells_Mouse0.91513888
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91180748
144NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90558214
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89791524
146CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89557793
147NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86000608
148VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85818021
149GATA1_19941826_ChIP-Seq_K562_Human0.85052403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.00356547
2MP0003705_abnormal_hypodermis_morpholog5.34172926
3MP0003279_aneurysm3.53406098
4MP0005671_abnormal_response_to3.37566818
5MP0005275_abnormal_skin_tensile3.28922532
6MP0005503_abnormal_tendon_morphology2.94911403
7MP0001958_emphysema2.67414151
8MP0009384_cardiac_valve_regurgitation2.57728946
9MP0003191_abnormal_cellular_cholesterol2.51076322
10MP0003436_decreased_susceptibility_to2.37446746
11MP0000750_abnormal_muscle_regeneration2.22299352
12MP0003091_abnormal_cell_migration2.22044113
13MP0005023_abnormal_wound_healing2.21191806
14MP0003566_abnormal_cell_adhesion2.09667287
15MP0003303_peritoneal_inflammation2.07005576
16MP0010352_gastrointestinal_tract_polyps2.02724763
17MP0003763_abnormal_thymus_physiology1.94630673
18MP0010030_abnormal_orbit_morphology1.93803020
19MP0005257_abnormal_intraocular_pressure1.88467308
20MP0002877_abnormal_melanocyte_morpholog1.87979038
21MP0005076_abnormal_cell_differentiation1.77185831
22MP0000858_altered_metastatic_potential1.76106516
23MP0001542_abnormal_bone_strength1.74416809
24MP0001533_abnormal_skeleton_physiology1.73610436
25MP0003172_abnormal_lysosome_physiology1.73514877
26MP0010155_abnormal_intestine_physiology1.67667428
27MP0000733_abnormal_muscle_development1.64647896
28MP0005623_abnormal_meninges_morphology1.63812811
29MP0003950_abnormal_plasma_membrane1.62320859
30MP0000716_abnormal_immune_system1.61913111
31MP0000343_altered_response_to1.60336180
32MP0008469_abnormal_protein_level1.59489258
33MP0003300_gastrointestinal_ulcer1.58674942
34MP0002060_abnormal_skin_morphology1.58371505
35MP0005058_abnormal_lysosome_morphology1.56973664
36MP0001243_abnormal_dermal_layer1.53902558
37MP0002398_abnormal_bone_marrow1.52699760
38MP0005508_abnormal_skeleton_morphology1.50976570
39MP0005390_skeleton_phenotype1.48410544
40MP0002933_joint_inflammation1.46360853
41MP0005000_abnormal_immune_tolerance1.45380364
42MP0000604_amyloidosis1.44618625
43MP0006054_spinal_hemorrhage1.41779315
44MP0009785_altered_susceptibility_to1.38552232
45MP0006082_CNS_inflammation1.38542927
46MP0005166_decreased_susceptibility_to1.38034190
47MP0008260_abnormal_autophagy1.35599680
48MP0003448_altered_tumor_morphology1.34641728
49MP0002419_abnormal_innate_immunity1.33810371
50MP0002148_abnormal_hypersensitivity_rea1.32762156
51MP0002998_abnormal_bone_remodeling1.32582744
52MP0000689_abnormal_spleen_morphology1.32509013
53MP0002429_abnormal_blood_cell1.31869715
54MP0002722_abnormal_immune_system1.29511111
55MP0004272_abnormal_basement_membrane1.28221542
56MP0002295_abnormal_pulmonary_circulatio1.24456535
57MP0004947_skin_inflammation1.22881550
58MP0009379_abnormal_foot_pigmentation1.21942511
59MP0000685_abnormal_immune_system1.20691063
60MP0000465_gastrointestinal_hemorrhage1.20472153
61MP0002166_altered_tumor_susceptibility1.18421623
62MP0010368_abnormal_lymphatic_system1.18382959
63MP0001299_abnormal_eye_distance/1.17818429
64MP0004510_myositis1.17712884
65MP0002896_abnormal_bone_mineralization1.17455920
66MP0003866_abnormal_defecation1.15716913
67MP0005165_increased_susceptibility_to1.14950704
68MP0001873_stomach_inflammation1.13908427
69MP0004808_abnormal_hematopoietic_stem1.13496602
70MP0002452_abnormal_antigen_presenting1.11662499
71MP0009250_abnormal_appendicular_skeleto1.11651003
72MP0001835_abnormal_antigen_presentation1.09278113
73MP0003795_abnormal_bone_structure1.08742330
74MP0002405_respiratory_system_inflammati1.07719674
75MP0004883_abnormal_blood_vessel1.05488681
76MP0005451_abnormal_body_composition1.05288770
77MP0005164_abnormal_response_to1.04799037
78MP0010307_abnormal_tumor_latency1.03240269
79MP0003806_abnormal_nucleotide_metabolis1.03139973
80MP0003724_increased_susceptibility_to1.03075661
81MP0009333_abnormal_splenocyte_physiolog1.00249624
82MP0009763_increased_sensitivity_to1.00045538
83MP0000163_abnormal_cartilage_morphology0.99784941
84MP0001879_abnormal_lymphatic_vessel0.98564978
85MP0001348_abnormal_lacrimal_gland0.98142087
86MP0002282_abnormal_trachea_morphology0.96109861
87MP0000703_abnormal_thymus_morphology0.95859763
88MP0005025_abnormal_response_to0.93934529
89MP0003453_abnormal_keratinocyte_physiol0.93666937
90MP0005387_immune_system_phenotype0.92825374
91MP0001790_abnormal_immune_system0.92825374
92MP0000767_abnormal_smooth_muscle0.91347216
93MP0005197_abnormal_uvea_morphology0.91321550
94MP0002723_abnormal_immune_serum0.89755904
95MP0003656_abnormal_erythrocyte_physiolo0.89032525
96MP0002113_abnormal_skeleton_development0.88751020
97MP0001853_heart_inflammation0.87686002
98MP0002006_tumorigenesis0.87200957
99MP0002115_abnormal_skeleton_extremities0.86377478
100MP0002132_abnormal_respiratory_system0.85855824
101MP0001819_abnormal_immune_cell0.85254096
102MP0001851_eye_inflammation0.84382388
103MP0002420_abnormal_adaptive_immunity0.84112006
104MP0005310_abnormal_salivary_gland0.83121934
105MP0000013_abnormal_adipose_tissue0.82562974
106MP0002332_abnormal_exercise_endurance0.81612822
107MP0002277_abnormal_respiratory_mucosa0.80843391
108MP0002177_abnormal_outer_ear0.80372827
109MP0003690_abnormal_glial_cell0.80135035
110MP0009278_abnormal_bone_marrow0.79831301
111MP0002168_other_aberrant_phenotype0.77670740
112MP0001800_abnormal_humoral_immune0.76120635
113MP0001845_abnormal_inflammatory_respons0.75914422
114MP0001663_abnormal_digestive_system0.75846493
115MP0000759_abnormal_skeletal_muscle0.75688105
116MP0008004_abnormal_stomach_pH0.74530545
117MP0005464_abnormal_platelet_physiology0.71722781
118MP0002089_abnormal_postnatal_growth/wei0.71561932
119MP0000249_abnormal_blood_vessel0.71450356
120MP0004233_abnormal_muscle_weight0.71381550
121MP0003075_altered_response_to0.71052995
122MP0000490_abnormal_crypts_of0.70600388
123MP0000627_abnormal_mammary_gland0.69449861
124MP0009764_decreased_sensitivity_to0.68154279
125MP0000049_abnormal_middle_ear0.67916303
126MP0009840_abnormal_foam_cell0.67747012
127MP0003186_abnormal_redox_activity0.67307881
128MP0005595_abnormal_vascular_smooth0.67131195
129MP0003329_amyloid_beta_deposits0.66028258
130MP0003828_pulmonary_edema0.65613461
131MP0001545_abnormal_hematopoietic_system0.65214446
132MP0005397_hematopoietic_system_phenotyp0.65214446
133MP0000681_abnormal_thyroid_gland0.64816089
134MP0000428_abnormal_craniofacial_morphol0.64695800
135MP0000920_abnormal_myelination0.62860921
136MP0003183_abnormal_peptide_metabolism0.62428294
137MP0005319_abnormal_enzyme/_coenzyme0.60050389
138MP0005584_abnormal_enzyme/coenzyme_acti0.57761020
139MP0008874_decreased_physiological_sensi0.57459796

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.41478093
2Premature rupture of membranes (HP:0001788)6.90924637
3Vertebral compression fractures (HP:0002953)5.27879064
4Abnormality of macrophages (HP:0004311)5.07747974
5Abnormality of glycolipid metabolism (HP:0010969)5.01858691
6Abnormality of liposaccharide metabolism (HP:0010968)5.01858691
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.01858691
8Peritonitis (HP:0002586)4.97393719
9Soft skin (HP:0000977)4.11445994
10Stomatitis (HP:0010280)3.93595105
11Shallow orbits (HP:0000586)3.90602607
12Amyloidosis (HP:0011034)3.77685712
13Dilatation of the ascending aorta (HP:0005111)3.74943158
14Aortic dissection (HP:0002647)3.71861467
15Biconcave vertebral bodies (HP:0004586)3.67881403
16Aortic aneurysm (HP:0004942)3.66576846
17Wormian bones (HP:0002645)3.46088335
18Ankle contracture (HP:0006466)3.44877830
19Recurrent gram-negative bacterial infections (HP:0005420)3.43722353
20Mediastinal lymphadenopathy (HP:0100721)3.43422744
21Abnormality of dentin (HP:0010299)3.40171943
22Atrophic scars (HP:0001075)3.40108876
23Spinal rigidity (HP:0003306)3.38993668
24Cervical subluxation (HP:0003308)3.34087297
25Cerebral aneurysm (HP:0004944)3.27859484
26Retrobulbar optic neuritis (HP:0100654)3.25931781
27Optic neuritis (HP:0100653)3.25931781
28Obstructive lung disease (HP:0006536)3.21917602
29Chronic obstructive pulmonary disease (HP:0006510)3.21917602
30T lymphocytopenia (HP:0005403)3.19126141
31Increased density of long bones (HP:0006392)3.18771519
32Increased IgM level (HP:0003496)3.15534916
33Osteolytic defects of the hand bones (HP:0009699)3.15007385
34Osteolytic defects of the phalanges of the hand (HP:0009771)3.15007385
35Increased connective tissue (HP:0009025)3.12903480
36Systemic lupus erythematosus (HP:0002725)3.10800035
37Short nail (HP:0001799)3.08684445
38Recurrent fungal infections (HP:0002841)3.04396790
39Petechiae (HP:0000967)3.03082248
40Recurrent skin infections (HP:0001581)3.01406369
41Abnormality of T cell number (HP:0011839)2.97468313
42Blue sclerae (HP:0000592)2.93365918
43Spinal cord lesions (HP:0100561)2.90698525
44Syringomyelia (HP:0003396)2.90698525
45Loss of speech (HP:0002371)2.89215923
46Fragile skin (HP:0001030)2.85567048
47Abnormal hemoglobin (HP:0011902)2.85134321
48Pulmonary infiltrates (HP:0002113)2.83088109
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.82847703
50Type 1 muscle fiber predominance (HP:0003803)2.82829723
51Vascular tortuosity (HP:0004948)2.79644380
52Meningitis (HP:0001287)2.79579590
53Hepatosplenomegaly (HP:0001433)2.76038369
54Purpura (HP:0000979)2.73110055
55Recurrent cutaneous fungal infections (HP:0011370)2.72163726
56Chronic mucocutaneous candidiasis (HP:0002728)2.72163726
57Urticaria (HP:0001025)2.66616088
58Increased serum ferritin (HP:0003281)2.65077706
59Pustule (HP:0200039)2.64325577
60Autoimmune thrombocytopenia (HP:0001973)2.63818206
61Gastrointestinal infarctions (HP:0005244)2.63171669
62Bladder diverticulum (HP:0000015)2.60868014
63Wrist flexion contracture (HP:0001239)2.59767942
64Beaking of vertebral bodies (HP:0004568)2.59418659
65Encephalitis (HP:0002383)2.59007623
66Spontaneous hematomas (HP:0007420)2.58713955
67Abnormality of polysaccharide metabolism (HP:0011012)2.57956335
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57956335
69Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57956335
70Elbow flexion contracture (HP:0002987)2.57025408
71Coxa vara (HP:0002812)2.55422723
72Follicular hyperkeratosis (HP:0007502)2.54863174
73Joint stiffness (HP:0001387)2.53904526
74Neonatal short-limb short stature (HP:0008921)2.52841569
75Vasculitis (HP:0002633)2.52008249
76Arterial tortuosity (HP:0005116)2.51389229
77Sparse lateral eyebrow (HP:0005338)2.50696373
78Hypergammaglobulinemia (HP:0010702)2.50588198
79Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48670415
80Achilles tendon contracture (HP:0001771)2.48376189
81Genu recurvatum (HP:0002816)2.45941974
82Disinhibition (HP:0000734)2.44123924
83Keratoconjunctivitis sicca (HP:0001097)2.40282290
84Gingivitis (HP:0000230)2.38141446
85Recurrent viral infections (HP:0004429)2.37511136
86Elevated erythrocyte sedimentation rate (HP:0003565)2.36195794
87Progressive neurologic deterioration (HP:0002344)2.35562935
88Myocardial infarction (HP:0001658)2.34526718
89Abnormality of T cells (HP:0002843)2.33547468
90Hemoptysis (HP:0002105)2.32982560
91Abnormality of the acetabulum (HP:0003170)2.30941342
92Abnormal delayed hypersensitivity skin test (HP:0002963)2.30581614
93Myositis (HP:0100614)2.28242034
94Leukocytosis (HP:0001974)2.27627739
95Episodic fever (HP:0001954)2.27249461
96Keratoconjunctivitis (HP:0001096)2.26535490
97Epistaxis (HP:0000421)2.26399352
98Chest pain (HP:0100749)2.24596963
99Autoimmune hemolytic anemia (HP:0001890)2.24307914
100Increased IgE level (HP:0003212)2.23265602
101Dysostosis multiplex (HP:0000943)2.21638760
102Abnormality of the Achilles tendon (HP:0005109)2.21044248
103Orchitis (HP:0100796)2.17774600
104Abnormality of iron homeostasis (HP:0011031)2.16656798
105Multiple lipomas (HP:0001012)2.16603722
106Recurrent abscess formation (HP:0002722)2.16189533
107Hyperextensible skin (HP:0000974)2.15645987
108Eczematoid dermatitis (HP:0000976)2.12571883
109Distal lower limb amyotrophy (HP:0008944)2.11916042
110Overgrowth (HP:0001548)2.10140945
111Thin bony cortex (HP:0002753)2.09717018
112Scapular winging (HP:0003691)2.09161631
113Abnormality of the peritoneum (HP:0002585)2.08325919
114Glomerulopathy (HP:0100820)2.08237962
115Abnormal delivery (HP:0001787)2.07594808
116Coronal craniosynostosis (HP:0004440)2.06829906
117Interstitial pulmonary disease (HP:0006530)2.06405284
118Spinal cord compression (HP:0002176)2.03851725
119Slender build (HP:0001533)2.03815943
120Distal upper limb amyotrophy (HP:0007149)2.02894828
121Upper limb amyotrophy (HP:0009129)2.02894828
122IgG deficiency (HP:0004315)2.02620103
123Granulocytopenia (HP:0001913)2.02559227
124Delayed cranial suture closure (HP:0000270)2.01903715
125Upper motor neuron abnormality (HP:0002127)2.01010532
126Trismus (HP:0000211)2.00307769
127Abnormality of the 2nd finger (HP:0004100)1.98740032
128Axonal loss (HP:0003447)1.97188369
129Mucopolysacchariduria (HP:0008155)1.95507455
130Urinary glycosaminoglycan excretion (HP:0003541)1.95507455
131Difficulty climbing stairs (HP:0003551)1.95357825
132Mutism (HP:0002300)1.95074084
133Anorexia (HP:0002039)1.94669977
134Gingival bleeding (HP:0000225)1.94435534
135Prolonged bleeding time (HP:0003010)1.93529595
136Distal lower limb muscle weakness (HP:0009053)1.93287535
137Mitral regurgitation (HP:0001653)1.93225519
138Inflammation of the large intestine (HP:0002037)1.93203405
139Acrocyanosis (HP:0001063)1.92492213
140Hypertensive crisis (HP:0100735)1.91214420
141Infantile muscular hypotonia (HP:0008947)1.91176008
142Abnormality of the distal phalanges of the toes (HP:0010182)1.90675506
143Mitral valve prolapse (HP:0001634)1.89877941
144Generalized amyotrophy (HP:0003700)1.88874467
145Broad metatarsal (HP:0001783)1.88582978
146Gangrene (HP:0100758)1.88231820
147Arthralgia (HP:0002829)1.87806051
148Vacuolated lymphocytes (HP:0001922)1.87241140
149Polyneuropathy (HP:0001271)1.86896013
150Abnormality of the pleura (HP:0002103)1.86750895
151Entropion (HP:0000621)1.85946644
152Spondylolisthesis (HP:0003302)1.85558105
153Hypertriglyceridemia (HP:0002155)1.84907376
154Thoracolumbar scoliosis (HP:0002944)1.84468119
155Basal ganglia calcification (HP:0002135)1.83644042
156Gastrointestinal inflammation (HP:0004386)1.82742539
157Prolonged neonatal jaundice (HP:0006579)1.82662872
158Broad face (HP:0000283)1.82633026
159Abnormality of the pericardium (HP:0001697)1.82105640
160Arterial thrombosis (HP:0004420)1.81372593
161Cellulitis (HP:0100658)1.81159041
162Abnormality of cells of the erythroid lineage (HP:0012130)1.80359598
163Mildly elevated creatine phosphokinase (HP:0008180)1.79650121
164Lymphopenia (HP:0001888)1.79415785
165Increased cerebral lipofuscin (HP:0011813)1.78581673
166Aplastic anemia (HP:0001915)1.78531383
167Decreased subcutaneous fat (HP:0001002)1.77983301
168Gastrointestinal dysmotility (HP:0002579)1.77070141
169Camptodactyly of toe (HP:0001836)1.76062567
170Recurrent bacterial skin infections (HP:0005406)1.72904160
171Buphthalmos (HP:0000557)1.70918681
172Natal tooth (HP:0000695)1.69947311
173Deviation of the hallux (HP:0010051)1.69525376
174Hand muscle atrophy (HP:0009130)1.69039107
175Reduced subcutaneous adipose tissue (HP:0003758)1.68979635
176Hematochezia (HP:0002573)1.68722712
177Bowel diverticulosis (HP:0005222)1.68617872
178Radial bowing (HP:0002986)1.67657143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.75655107
2TESK24.39155317
3TESK13.98281048
4LIMK13.59311407
5TRIB33.22557897
6ERN13.07902571
7MAP4K12.99367967
8PIM22.92396480
9LATS22.87063929
10RIPK42.77390868
11TXK2.54700489
12RPS6KA42.48846995
13MOS2.35573901
14TTN2.32564155
15LRRK22.13877161
16DDR22.04164809
17PKN21.90657676
18FES1.88382165
19GRK71.88120559
20PBK1.83759604
21PRPF4B1.71931746
22IRAK41.67918963
23TRPM71.65608031
24ILK1.63768127
25BMX1.57832776
26GRK61.52232840
27MAP3K31.48798578
28SYK1.44812927
29BTK1.42527205
30IKBKE1.41783614
31ARAF1.39691323
32TBK11.38531535
33PAK21.35076887
34MAP3K111.30605281
35PIK3CG1.30115532
36BCKDK1.27910435
37TAOK21.24901751
38TLK11.20904919
39MAP3K121.20023855
40LYN1.18698080
41TAOK31.17872206
42ABL21.13904705
43MAP2K31.11002912
44TNK21.09966592
45PTK2B1.09210867
46LCK1.09070492
47VRK21.07861929
48ERBB31.05884873
49PDGFRA1.05657857
50BMPR21.04786064
51ITK1.04348871
52PAK41.02557699
53NEK90.98041096
54MATK0.97470328
55KDR0.97253459
56MYLK0.94077893
57TEC0.93791705
58KIT0.88521055
59IKBKB0.86616383
60TYK20.80279376
61STK30.80153584
62BLK0.79901597
63MAP3K80.79035769
64DAPK10.78458915
65MAP3K10.78218261
66EPHB10.76502629
67PAK10.75241385
68PRKG20.74935323
69MAPKAPK30.74132965
70ROCK10.73904345
71TAOK10.73427744
72JAK20.73398298
73SIK30.73145628
74JAK30.72856071
75PAK60.72703832
76CAMKK20.70654936
77MAP3K100.70023916
78TGFBR10.69404049
79DYRK1B0.65780559
80STK100.65444787
81DAPK30.63192824
82SCYL20.62795883
83PTK20.62630084
84CDK60.62109009
85MAP3K140.59370006
86MAPKAPK20.57292981
87MAP2K10.55541699
88HCK0.51448082
89CAMKK10.50774288
90CDK190.49627999
91HIPK20.49495772
92CDC42BPA0.49229320
93PTK60.48613917
94MAP3K130.48278841
95PRKCQ0.47987051
96FYN0.47525597
97PRKD10.46929168
98IRAK10.46194057
99CSK0.45723556
100ROCK20.44415358
101CDK140.43916299
102FRK0.43360415
103RPS6KA50.42644365
104PRKD20.42555265
105IRAK30.42317043
106MST1R0.41892580
107MAP3K50.41522862
108ADRBK20.41357311
109ACVR1B0.41048018
110CSF1R0.40431009
111AURKA0.39647964
112JAK10.39442135
113TGFBR20.38656292
114MET0.38644975
115PIM10.38537226
116MARK30.37718213
117MAPK70.37653904
118PDK10.37572470
119GRK50.36602965
120PAK30.35729895
121MAP3K60.35572021
122LMTK20.34690554
123FGR0.34550425
124PDPK10.34047064
125BRAF0.33539877
126EPHB20.33529272
127CDK150.32812912
128MAP2K60.32542197
129MAPKAPK50.31960423
130PRKCD0.31386503
131ABL10.30943388
132ZAP700.30687176
133BUB10.29665410
134RIPK10.29199080
135LATS10.28941003
136INSR0.28710029
137MAPK120.28438064
138DMPK0.28098071
139CDK180.27819987
140FER0.27518044
141AURKB0.27442267
142EIF2AK10.27406276
143FLT30.26962567
144CDK11A0.26774661
145RET0.26449084
146MAP2K20.25194935

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.10558844
2Autoimmune thyroid disease_Homo sapiens_hsa053202.92753713
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.83815079
4Primary immunodeficiency_Homo sapiens_hsa053402.70685127
5Shigellosis_Homo sapiens_hsa051312.49362724
6Asthma_Homo sapiens_hsa053102.46736180
7Malaria_Homo sapiens_hsa051442.46718462
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.38995650
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.23731998
10Type I diabetes mellitus_Homo sapiens_hsa049402.14468720
11Leishmaniasis_Homo sapiens_hsa051401.98464390
12Phagosome_Homo sapiens_hsa041451.85926375
13Graft-versus-host disease_Homo sapiens_hsa053321.85362249
14Proteoglycans in cancer_Homo sapiens_hsa052051.85334961
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.76942588
16p53 signaling pathway_Homo sapiens_hsa041151.76564518
17Apoptosis_Homo sapiens_hsa042101.75281708
18Legionellosis_Homo sapiens_hsa051341.74151644
19TNF signaling pathway_Homo sapiens_hsa046681.69908569
20Focal adhesion_Homo sapiens_hsa045101.69608850
21Pertussis_Homo sapiens_hsa051331.66962719
22Lysosome_Homo sapiens_hsa041421.63011802
23Tuberculosis_Homo sapiens_hsa051521.61863696
24Salmonella infection_Homo sapiens_hsa051321.60634096
25Osteoclast differentiation_Homo sapiens_hsa043801.59376948
26Viral myocarditis_Homo sapiens_hsa054161.58819010
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53429588
28ECM-receptor interaction_Homo sapiens_hsa045121.52560725
29Bladder cancer_Homo sapiens_hsa052191.52386480
30Antigen processing and presentation_Homo sapiens_hsa046121.49277101
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49145986
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44289222
33T cell receptor signaling pathway_Homo sapiens_hsa046601.40059997
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.34774305
35Rheumatoid arthritis_Homo sapiens_hsa053231.30448055
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.26109462
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.25743584
38Small cell lung cancer_Homo sapiens_hsa052221.23998743
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22751977
40Toxoplasmosis_Homo sapiens_hsa051451.22253833
41Amoebiasis_Homo sapiens_hsa051461.21807103
42Chronic myeloid leukemia_Homo sapiens_hsa052201.20758178
43Platelet activation_Homo sapiens_hsa046111.13521653
44MicroRNAs in cancer_Homo sapiens_hsa052061.10944070
45Melanoma_Homo sapiens_hsa052181.09569643
46Measles_Homo sapiens_hsa051621.08057549
47Proteasome_Homo sapiens_hsa030501.07753802
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07712885
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06138652
50Adherens junction_Homo sapiens_hsa045201.06072249
51Hepatitis B_Homo sapiens_hsa051611.04988060
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99592584
53African trypanosomiasis_Homo sapiens_hsa051430.99472903
54Viral carcinogenesis_Homo sapiens_hsa052030.97852132
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96164868
56Staphylococcus aureus infection_Homo sapiens_hsa051500.95230227
57Pancreatic cancer_Homo sapiens_hsa052120.94935170
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94094719
59HIF-1 signaling pathway_Homo sapiens_hsa040660.94008418
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91104831
61HTLV-I infection_Homo sapiens_hsa051660.90638740
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90286189
63Vibrio cholerae infection_Homo sapiens_hsa051100.90100149
64TGF-beta signaling pathway_Homo sapiens_hsa043500.87012666
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86699748
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.86026817
67Protein export_Homo sapiens_hsa030600.85865963
68Endocytosis_Homo sapiens_hsa041440.83326971
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83143446
70Hematopoietic cell lineage_Homo sapiens_hsa046400.82257754
71Oxidative phosphorylation_Homo sapiens_hsa001900.80696833
72VEGF signaling pathway_Homo sapiens_hsa043700.80336179
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78800430
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78651012
75Systemic lupus erythematosus_Homo sapiens_hsa053220.76263969
76Epstein-Barr virus infection_Homo sapiens_hsa051690.73919928
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73867279
78Dilated cardiomyopathy_Homo sapiens_hsa054140.73110360
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72927419
80B cell receptor signaling pathway_Homo sapiens_hsa046620.71998631
81Rap1 signaling pathway_Homo sapiens_hsa040150.71610047
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71097156
83Chemokine signaling pathway_Homo sapiens_hsa040620.69845807
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69739118
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69446977
86Prion diseases_Homo sapiens_hsa050200.68690704
87Glioma_Homo sapiens_hsa052140.68011297
88Glutathione metabolism_Homo sapiens_hsa004800.64667251
89Other glycan degradation_Homo sapiens_hsa005110.63672986
90Collecting duct acid secretion_Homo sapiens_hsa049660.63233805
91Caffeine metabolism_Homo sapiens_hsa002320.62709048
92Allograft rejection_Homo sapiens_hsa053300.61194268
93Influenza A_Homo sapiens_hsa051640.61175585
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59890613
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57889391
96Hepatitis C_Homo sapiens_hsa051600.57292687
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.55857391
98Galactose metabolism_Homo sapiens_hsa000520.55166204
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.55012529
100Renal cell carcinoma_Homo sapiens_hsa052110.53480801
101Acute myeloid leukemia_Homo sapiens_hsa052210.51488137
102Parkinsons disease_Homo sapiens_hsa050120.50744747
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49273220
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49234426
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47518311
106Complement and coagulation cascades_Homo sapiens_hsa046100.46668534
107Sulfur relay system_Homo sapiens_hsa041220.45453421
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.43909023
109Hippo signaling pathway_Homo sapiens_hsa043900.42441333
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42264516
111Alzheimers disease_Homo sapiens_hsa050100.42217600
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41567361
113Ras signaling pathway_Homo sapiens_hsa040140.41063906
114Herpes simplex infection_Homo sapiens_hsa051680.41039275
115Pathways in cancer_Homo sapiens_hsa052000.39963288
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.39332146
117Prostate cancer_Homo sapiens_hsa052150.38472508
118Pentose phosphate pathway_Homo sapiens_hsa000300.37211183
119N-Glycan biosynthesis_Homo sapiens_hsa005100.35963976
120Pyrimidine metabolism_Homo sapiens_hsa002400.34561271
121Arachidonic acid metabolism_Homo sapiens_hsa005900.29961767
122Sulfur metabolism_Homo sapiens_hsa009200.27452390
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26014026
124Regulation of autophagy_Homo sapiens_hsa041400.21484555
125Fructose and mannose metabolism_Homo sapiens_hsa000510.18204000
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.16570776
127Huntingtons disease_Homo sapiens_hsa050160.14400334
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.12150733

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