S100A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)9.78181842
2regulation of cilium movement (GO:0003352)7.36467041
3protein polyglutamylation (GO:0018095)7.18387479
4regulation of chromatin binding (GO:0035561)7.16062393
5succinate metabolic process (GO:0006105)7.10617335
6tricarboxylic acid cycle (GO:0006099)6.55540594
7glomerular visceral epithelial cell development (GO:0072015)6.36476220
8peptidyl-arginine omega-N-methylation (GO:0035247)6.36338415
9regulation of female gonad development (GO:2000194)6.18998859
10adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.10656331
11glomerular epithelial cell development (GO:0072310)5.64815887
12negative regulation of cytosolic calcium ion concentration (GO:0051481)5.52623682
13peptidyl-arginine methylation (GO:0018216)5.28288047
14peptidyl-arginine N-methylation (GO:0035246)5.28288047
15behavioral response to cocaine (GO:0048148)5.28270037
16positive regulation of mitochondrial fission (GO:0090141)5.26876773
17activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO5.21403494
18axoneme assembly (GO:0035082)5.13626101
19auditory receptor cell differentiation (GO:0042491)4.97586614
20cilium morphogenesis (GO:0060271)4.92980328
21intraciliary transport (GO:0042073)4.91721920
22histone arginine methylation (GO:0034969)4.90273818
23microtubule severing (GO:0051013)4.82542831
24activation of protein kinase A activity (GO:0034199)4.65378227
25regulation of microtubule-based movement (GO:0060632)4.57627205
26detection of calcium ion (GO:0005513)4.54586910
27axonemal dynein complex assembly (GO:0070286)4.49528847
28dopamine receptor signaling pathway (GO:0007212)4.37396752
29protein maturation by protein folding (GO:0022417)4.32542647
30pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.27402114
31antibacterial humoral response (GO:0019731)4.26654138
32proteasome assembly (GO:0043248)4.26575949
33olfactory bulb development (GO:0021772)4.24821662
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.24541479
35negative regulation of cell aging (GO:0090344)4.18898989
36regulation of mitochondrial fission (GO:0090140)4.18496892
37regulation of cell aging (GO:0090342)4.16757605
38adipose tissue development (GO:0060612)4.14671064
39regulation of mitochondrial depolarization (GO:0051900)4.09821809
40positive regulation of B cell differentiation (GO:0045579)4.05419110
41cytoplasmic mRNA processing body assembly (GO:0033962)4.05039314
42cAMP biosynthetic process (GO:0006171)4.01255295
43innate immune response in mucosa (GO:0002227)3.97523846
44pyrimidine nucleotide catabolic process (GO:0006244)3.96613252
45antimicrobial humoral response (GO:0019730)3.93467634
46cilium movement (GO:0003341)3.92732421
47establishment of integrated proviral latency (GO:0075713)3.75194195
48protein K6-linked ubiquitination (GO:0085020)3.73747610
49mitotic cell cycle arrest (GO:0071850)3.73335578
50calcium-mediated signaling using intracellular calcium source (GO:0035584)3.72976793
51cellular response to glucagon stimulus (GO:0071377)3.72860271
52oligosaccharide catabolic process (GO:0009313)3.72614245
53base-excision repair, AP site formation (GO:0006285)3.71272381
54regulation of synapse structural plasticity (GO:0051823)3.69811168
55response to caffeine (GO:0031000)3.68644178
56positive regulation of protein homooligomerization (GO:0032464)3.66937041
57chemical homeostasis within a tissue (GO:0048875)3.63999469
58regulation of sodium ion transmembrane transporter activity (GO:2000649)3.60585890
59establishment of viral latency (GO:0019043)3.60093271
60neuron cell-cell adhesion (GO:0007158)3.55352696
61mating behavior (GO:0007617)3.53341530
62positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.52564515
63regulation of heart rate by cardiac conduction (GO:0086091)3.42424348
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.41503633
65regulation of spindle organization (GO:0090224)3.40254808
66negative regulation of ligase activity (GO:0051352)3.37343178
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37343178
68peptidyl-arginine modification (GO:0018195)3.34184048
69cellular potassium ion transport (GO:0071804)3.34100438
70potassium ion transmembrane transport (GO:0071805)3.34100438
71membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.33482557
72glycogen catabolic process (GO:0005980)3.31911756
73telomere maintenance via semi-conservative replication (GO:0032201)3.30640751
74melanosome transport (GO:0032402)3.29128531
75positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.28380581
76protein retention in ER lumen (GO:0006621)3.28237031
77mucosal immune response (GO:0002385)3.27840942
78magnesium ion transport (GO:0015693)3.21993180
79photoreceptor cell maintenance (GO:0045494)3.21770501
80lipopolysaccharide biosynthetic process (GO:0009103)3.19619870
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16859489
82nuclear envelope reassembly (GO:0031468)3.15722654
83mitotic nuclear envelope reassembly (GO:0007084)3.15722654
84female mating behavior (GO:0060180)3.14901040
85COPI coating of Golgi vesicle (GO:0048205)3.13824425
86Golgi transport vesicle coating (GO:0048200)3.13824425
87peptidyl-glutamic acid modification (GO:0018200)3.13008595
88ribosome assembly (GO:0042255)3.12755865
89regulation of protein kinase A signaling (GO:0010738)3.11880946
90atrial cardiac muscle cell action potential (GO:0086014)3.11831981
91organ or tissue specific immune response (GO:0002251)3.11729109
92membrane raft organization (GO:0031579)3.11559708
93establishment of melanosome localization (GO:0032401)3.11177429
94glucan catabolic process (GO:0009251)3.09892936
95pigment granule transport (GO:0051904)3.09259124
96regulation of sodium ion transmembrane transport (GO:1902305)3.07648883
97potassium ion homeostasis (GO:0055075)3.07603124
98morphogenesis of an endothelium (GO:0003159)3.07318783
99endothelial tube morphogenesis (GO:0061154)3.07318783
100barbed-end actin filament capping (GO:0051016)3.06398464
101maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06063656
102relaxation of cardiac muscle (GO:0055119)3.05849642
103microtubule bundle formation (GO:0001578)3.05653664
104brain morphogenesis (GO:0048854)3.05589781
105response to amphetamine (GO:0001975)3.05268391
106male sex determination (GO:0030238)3.04306168
107regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04044716
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03653016
109potassium ion transport (GO:0006813)3.02214316
110pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.02129416
111sensory perception of smell (GO:0007608)23.8865984
112melanosome localization (GO:0032400)2.98024544
113regulation of cell communication by electrical coupling (GO:0010649)2.96894115
114negative regulation of astrocyte differentiation (GO:0048712)2.96768298
115negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.96701794
116positive regulation of protein oligomerization (GO:0032461)2.96616780
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.96216596
118secondary heart field specification (GO:0003139)2.95594426
119heart field specification (GO:0003128)2.95594426
120regulation of cellular amino acid metabolic process (GO:0006521)2.94016079
121response to glucagon (GO:0033762)2.93866690
122deoxyribonucleotide catabolic process (GO:0009264)2.93856713
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.93715307
124establishment of pigment granule localization (GO:0051905)2.93027136
125membrane repolarization during action potential (GO:0086011)2.92985808
126negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.91606080
127hair cell differentiation (GO:0035315)2.90626251
128ovulation cycle (GO:0042698)2.89740534
129DNA excision (GO:0044349)2.89710905
130nucleotide-excision repair, DNA damage removal (GO:0000718)2.89710905
131epithelial cilium movement (GO:0003351)2.89702664
132DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89529638
133cardiac conduction (GO:0061337)2.88439811
134deoxyribose phosphate catabolic process (GO:0046386)2.87810921
135axonal fasciculation (GO:0007413)2.86787217
136striatum development (GO:0021756)2.85234020
137galactose catabolic process (GO:0019388)2.84838322
138intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83847988
139signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83847988
140negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.83548425
141negative regulation of sodium ion transport (GO:0010766)2.82695019
142response to inactivity (GO:0014854)2.82127052
143pigment granule localization (GO:0051875)2.81934812
144negative regulation of protein ubiquitination (GO:0031397)2.81789609
145regulation of female receptivity (GO:0045924)2.81736575
146negative regulation of transcription regulatory region DNA binding (GO:2000678)2.81597036
147signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80965570
148signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80965570
149signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80965570
150regulation of protein homooligomerization (GO:0032462)2.80686641
151regulation of sodium ion transport (GO:0002028)2.79164641
152antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.78472975
153inner ear receptor cell differentiation (GO:0060113)2.77755675
154regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.77512853
155regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.77512853
156lipopolysaccharide metabolic process (GO:0008653)2.75585927
157signal transduction involved in DNA damage checkpoint (GO:0072422)2.74052809
158signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74052809
159negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.72678460
160cellular polysaccharide catabolic process (GO:0044247)2.71768123
161transcription-coupled nucleotide-excision repair (GO:0006283)2.71533642
162positive regulation of DNA-dependent DNA replication (GO:2000105)2.71262635
163muscle cell migration (GO:0014812)2.70881145
164potassium ion export (GO:0071435)2.70496781
165cellular copper ion homeostasis (GO:0006878)2.70006839
166response to gravity (GO:0009629)2.69531041
167nerve growth factor signaling pathway (GO:0038180)2.68697193
168cilium assembly (GO:0042384)2.68323483
169neuron apoptotic process (GO:0051402)2.68097079
170base-excision repair (GO:0006284)2.67438237
171regulation of release of cytochrome c from mitochondria (GO:0090199)2.66048482
172protein K11-linked ubiquitination (GO:0070979)2.65870927
173signal transduction involved in cell cycle checkpoint (GO:0072395)2.65450098
174connective tissue development (GO:0061448)2.65277006
175positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.64685490
176telomere maintenance via recombination (GO:0000722)2.64117608
177endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.62938387
178facial nerve structural organization (GO:0021612)2.62571492
179response to arsenic-containing substance (GO:0046685)2.62255350
180positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.62207959
181negative regulation of protein kinase B signaling (GO:0051898)2.61985806
182forebrain neuron development (GO:0021884)2.61572584
183reproductive behavior (GO:0019098)2.60624593
184cAMP metabolic process (GO:0046058)2.60541158
185regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.58965598
186sensory perception of taste (GO:0050909)2.58500685
187negative regulation of cation channel activity (GO:2001258)2.58297388
188regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.57384992
189positive regulation of actin filament depolymerization (GO:0030836)2.57314235
190GDP-mannose metabolic process (GO:0019673)2.55722970
191positive regulation of lamellipodium organization (GO:1902745)2.55629181
192skin morphogenesis (GO:0043589)2.54699755
193regulation of ubiquitin-protein transferase activity (GO:0051438)2.54231697
194negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.53717037
195adenosine receptor signaling pathway (GO:0001973)2.50179885
196low-density lipoprotein particle clearance (GO:0034383)2.49449910
197response to nerve growth factor (GO:1990089)2.48244302
198sensory perception of chemical stimulus (GO:0007606)13.7764837
199protein insertion into membrane (GO:0051205)12.4768260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.78551105
2TAF15_26573619_Chip-Seq_HEK293_Human4.09954697
3ZNF263_19887448_ChIP-Seq_K562_Human3.91132398
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26184087
5GBX2_23144817_ChIP-Seq_PC3_Human3.07467599
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.92431773
7DROSHA_22980978_ChIP-Seq_HELA_Human2.91637714
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87171823
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83995753
10GATA1_22025678_ChIP-Seq_K562_Human2.77086989
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52866751
12BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.47504851
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.45696334
14CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38847758
15DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.37289431
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34843064
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34287183
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17143247
19E2F7_22180533_ChIP-Seq_HELA_Human2.15560040
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09627666
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06270133
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02686780
23* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00980939
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.97231630
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96075810
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93768032
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.91807350
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87119278
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87119278
30DCP1A_22483619_ChIP-Seq_HELA_Human1.86151525
31ATF3_27146783_Chip-Seq_COLON_Human1.84655037
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81418929
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.80838773
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.79517898
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.78332511
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77527795
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.74774621
38* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.72746707
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71872194
40* ELK3_25401928_ChIP-Seq_HUVEC_Human1.71033910
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70108716
42KDM2B_26808549_Chip-Seq_K562_Human1.68394363
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67821214
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66982771
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66152954
46ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.64919385
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64648424
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64438553
49XRN2_22483619_ChIP-Seq_HELA_Human1.62589249
50AHR_22903824_ChIP-Seq_MCF-7_Human1.61772156
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60116297
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59893820
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58989220
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.58362200
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58312797
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57920916
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.57869102
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56566132
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.56034757
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54026063
61* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52758741
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51628968
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51515882
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48724232
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.48284379
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47724273
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47654450
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47479124
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47097527
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45268040
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.43416023
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42496037
73RACK7_27058665_Chip-Seq_MCF-7_Human1.42325401
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41906241
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41754947
76REST_21632747_ChIP-Seq_MESCs_Mouse1.41346506
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41112086
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40092301
79TFEB_21752829_ChIP-Seq_HELA_Human1.40025149
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38449395
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37865616
82GABP_19822575_ChIP-Seq_HepG2_Human1.37710200
83RNF2_27304074_Chip-Seq_NSC_Mouse1.37030121
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36529098
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35829661
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35825581
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34850615
88VDR_21846776_ChIP-Seq_THP-1_Human1.34793720
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34259608
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32125812
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31544756
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30441183
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.30096305
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.28209608
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28193756
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28145538
97VDR_23849224_ChIP-Seq_CD4+_Human1.27181965
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25815959
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.25335717
100RARB_27405468_Chip-Seq_BRAIN_Mouse1.25278029
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25065104
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24530884
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.23332686
104JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22775400
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22575861
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22575861
107LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21900262
108* BCOR_27268052_Chip-Seq_Bcells_Human1.21632224
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21473534
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21202305
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20646100
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20487423
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19750140
114BCAT_22108803_ChIP-Seq_LS180_Human1.19496200
115RNF2_27304074_Chip-Seq_ESCs_Mouse1.19393110
116* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19157226
117NCOR1_26117541_ChIP-Seq_K562_Human1.18951860
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18578877
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18578877
120VDR_22108803_ChIP-Seq_LS180_Human1.18069246
121P300_19829295_ChIP-Seq_ESCs_Human1.16771126
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16103416
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14746252
124RING1B_27294783_Chip-Seq_ESCs_Mouse1.14424626
125SMAD4_21741376_ChIP-Seq_HESCs_Human1.14283673
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14246777
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12534540
128EZH2_27294783_Chip-Seq_ESCs_Mouse1.12338606
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11898942
130FOXP3_21729870_ChIP-Seq_TREG_Human1.11755653
131HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11203426
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10792832
133CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09952663
134BCL6_27268052_Chip-Seq_Bcells_Human1.09794638
135SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09730566
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09423418
137CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08970966
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.08590740
139SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07983368
140GATA3_27048872_Chip-Seq_THYMUS_Human1.07440635
141ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06955386
142ERG_21242973_ChIP-ChIP_JURKAT_Human1.06594257
143PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06185773
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06184000
145RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05962297
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05849164
147SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05371930
148ELK1_19687146_ChIP-ChIP_HELA_Human1.05311953
149FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04290956
150PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04225875
151MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04203591
152TCF4_22108803_ChIP-Seq_LS180_Human1.04081407
153SMAD4_21799915_ChIP-Seq_A2780_Human1.03569425
154TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02239233
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02186649
156JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01510484
157PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01268035
158MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00917528
159PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00711034
160WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00073867
161E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99346942
162OCT4_20526341_ChIP-Seq_ESCs_Human0.99334838
163CTCF_26484167_Chip-Seq_Bcells_Mouse0.98120214
164MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97935620
165CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97552016
166KDM5A_27292631_Chip-Seq_BREAST_Human0.97400987
167RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97310794
168STAT1_20625510_ChIP-Seq_HELA_Human0.96741264
169TP53_22127205_ChIP-Seq_IMR90_Human0.96582372
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96235606
171UBF1/2_26484160_Chip-Seq_HMECs_Human0.96054698
172PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95712898
173* FOXP1_21924763_ChIP-Seq_HESCs_Human0.95590158
174P68_20966046_ChIP-Seq_HELA_Human0.95217334
175FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94496694
176CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94417377
177SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94237823
178* CTCF_20526341_ChIP-Seq_ESCs_Human0.93803665
179RING1B_27294783_Chip-Seq_NPCs_Mouse0.93042045
180MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92841376
181KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92671723
182EZH2_27304074_Chip-Seq_ESCs_Mouse0.92516412
183TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91734526
184NCOR_22424771_ChIP-Seq_293T_Human0.91353175
185SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91338973
186SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90831307
187* NANOG_20526341_ChIP-Seq_ESCs_Human0.90473713
188LXR_22292898_ChIP-Seq_THP-1_Human0.90340999
189* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90100200
190CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87829659
191TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87811270
192TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87258771
193FOXH1_21741376_ChIP-Seq_EPCs_Human0.87019466
194KLF5_25053715_ChIP-Seq_YYC3_Human0.84620970
195CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84528246
196* TAF2_19829295_ChIP-Seq_ESCs_Human0.83829750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium4.78919353
2MP0000566_synostosis4.49595959
3MP0005499_abnormal_olfactory_system4.40725955
4MP0005394_taste/olfaction_phenotype4.40725955
5MP0003191_abnormal_cellular_cholesterol3.73100470
6MP0005257_abnormal_intraocular_pressure2.99217878
7MP0005645_abnormal_hypothalamus_physiol2.92202630
8MP0000751_myopathy2.77414726
9MP0009840_abnormal_foam_cell2.71506103
10MP0001986_abnormal_taste_sensitivity2.65551648
11MP0003806_abnormal_nucleotide_metabolis2.54711593
12MP0002184_abnormal_innervation2.49274028
13MP0003878_abnormal_ear_physiology2.28572105
14MP0005377_hearing/vestibular/ear_phenot2.28572105
15MP0000749_muscle_degeneration2.18511728
16MP0002822_catalepsy2.13010192
17MP0000343_altered_response_to2.10909832
18MP0008260_abnormal_autophagy2.07391244
19MP0003656_abnormal_erythrocyte_physiolo2.04830438
20MP0003950_abnormal_plasma_membrane2.00603782
21MP0001984_abnormal_olfaction15.4859957
22MP0009278_abnormal_bone_marrow1.97039346
23MP0000747_muscle_weakness1.93506141
24MP0009780_abnormal_chondrocyte_physiolo1.85608388
25MP0001485_abnormal_pinna_reflex1.85324597
26MP0005083_abnormal_biliary_tract1.81933665
27MP0000490_abnormal_crypts_of1.75533004
28MP0000858_altered_metastatic_potential1.72274154
29MP0000750_abnormal_muscle_regeneration1.71140717
30MP0003566_abnormal_cell_adhesion1.69364854
31MP0002332_abnormal_exercise_endurance1.67999550
32MP0005084_abnormal_gallbladder_morpholo1.67595640
33MP0002160_abnormal_reproductive_system1.65967436
34MP0003705_abnormal_hypodermis_morpholog1.63525173
35MP0003880_abnormal_central_pattern1.63379493
36MP0002653_abnormal_ependyma_morphology1.62270401
37MP0001853_heart_inflammation1.62255167
38MP0003329_amyloid_beta_deposits1.60971539
39MP0003315_abnormal_perineum_morphology1.58927052
40MP0000372_irregular_coat_pigmentation1.58565535
41MP0002928_abnormal_bile_duct1.58377773
42MP0009697_abnormal_copulation1.57816028
43MP0003221_abnormal_cardiomyocyte_apopto1.45562029
44MP0002734_abnormal_mechanical_nocicepti1.43065400
45MP0001542_abnormal_bone_strength1.41726260
46MP0009053_abnormal_anal_canal1.35778476
47MP0001299_abnormal_eye_distance/1.34962165
48MP0003453_abnormal_keratinocyte_physiol1.34665263
49MP0003077_abnormal_cell_cycle1.33122684
50MP0004957_abnormal_blastocyst_morpholog1.33084297
51MP0002557_abnormal_social/conspecific_i1.31698174
52MP0002752_abnormal_somatic_nervous1.30620490
53MP0001727_abnormal_embryo_implantation1.29682374
54MP0002877_abnormal_melanocyte_morpholog1.28783395
55MP0001486_abnormal_startle_reflex1.26252297
56MP0002060_abnormal_skin_morphology1.24169660
57MP0005085_abnormal_gallbladder_physiolo1.20256080
58MP0003252_abnormal_bile_duct1.19702933
59MP0005501_abnormal_skin_physiology1.18835989
60MP0002233_abnormal_nose_morphology1.18211160
61MP0000516_abnormal_urinary_system1.17985807
62MP0005367_renal/urinary_system_phenotyp1.17985807
63MP0009764_decreased_sensitivity_to1.15797536
64MP0003436_decreased_susceptibility_to1.15268583
65MP0005330_cardiomyopathy1.13626961
66MP0002272_abnormal_nervous_system1.13401746
67MP0005410_abnormal_fertilization1.11988572
68MP0001188_hyperpigmentation1.10720326
69MP0004272_abnormal_basement_membrane1.10526998
70MP0002148_abnormal_hypersensitivity_rea1.09426023
71MP0000358_abnormal_cell_content/1.06344464
72MP0003186_abnormal_redox_activity1.05439745
73MP0002909_abnormal_adrenal_gland1.03786277
74MP0005646_abnormal_pituitary_gland1.02808545
75MP0008875_abnormal_xenobiotic_pharmacok1.02790359
76MP0000681_abnormal_thyroid_gland1.00582334
77MP0005451_abnormal_body_composition1.00489281
78MP0003635_abnormal_synaptic_transmissio0.99619856
79MP0003123_paternal_imprinting0.98972802
80MP0002882_abnormal_neuron_morphology0.98643835
81MP0000537_abnormal_urethra_morphology0.96686528
82MP0002796_impaired_skin_barrier0.94624524
83MP0001216_abnormal_epidermal_layer0.93555570
84MP0004270_analgesia0.93330078
85MP0005623_abnormal_meninges_morphology0.93308095
86MP0000778_abnormal_nervous_system0.92323967
87MP0000313_abnormal_cell_death0.91677423
88MP0005621_abnormal_cell_physiology0.91283851
89MP0005166_decreased_susceptibility_to0.88758269
90MP0005384_cellular_phenotype0.86021757
91MP0000604_amyloidosis0.85964288
92MP0005164_abnormal_response_to0.85910421
93MP0001545_abnormal_hematopoietic_system0.83664440
94MP0005397_hematopoietic_system_phenotyp0.83664440
95MP0008438_abnormal_cutaneous_collagen0.83585290
96MP0002063_abnormal_learning/memory/cond0.83514923
97MP0003111_abnormal_nucleus_morphology0.83079292
98MP0006054_spinal_hemorrhage0.81634546
99MP0005197_abnormal_uvea_morphology0.81578115
100MP0001533_abnormal_skeleton_physiology0.80221935
101MP0009931_abnormal_skin_appearance0.77975407
102MP0003091_abnormal_cell_migration0.76912971
103MP0000003_abnormal_adipose_tissue0.76450763
104MP0002111_abnormal_tail_morphology0.75697194
105MP0005389_reproductive_system_phenotype0.75193125
106MP0002019_abnormal_tumor_incidence0.75142747
107MP0003075_altered_response_to0.74956772
108MP0005390_skeleton_phenotype0.74664668
109MP0002152_abnormal_brain_morphology0.73907429
110MP0004811_abnormal_neuron_physiology0.72892167
111MP0002254_reproductive_system_inflammat0.72735139
112MP0005187_abnormal_penis_morphology0.72386011
113MP0005551_abnormal_eye_electrophysiolog0.71597159
114MP0005464_abnormal_platelet_physiology0.71399847
115MP0009333_abnormal_splenocyte_physiolog0.70768447
116MP0006082_CNS_inflammation0.70327459
117MP0004947_skin_inflammation0.67916331
118MP0003279_aneurysm0.66873247
119MP0001970_abnormal_pain_threshold0.66620480
120MP0010771_integument_phenotype0.66169423
121MP0005584_abnormal_enzyme/coenzyme_acti0.65790309
122MP0005360_urolithiasis0.65662979
123MP0001243_abnormal_dermal_layer0.65100128
124MP0008469_abnormal_protein_level0.64374163
125MP0002572_abnormal_emotion/affect_behav0.64327402
126MP0002210_abnormal_sex_determination0.62513348
127MP0004859_abnormal_synaptic_plasticity0.61091445
128MP0003942_abnormal_urinary_system0.60834166
129MP0005409_darkened_coat_color0.60483181
130MP0001529_abnormal_vocalization0.60388310
131MP0004264_abnormal_extraembryonic_tissu0.59550570
132MP0008057_abnormal_DNA_replication0.59035457
133MP0010094_abnormal_chromosome_stability0.58608613
134MP0002452_abnormal_antigen_presenting0.58426648
135MP0002229_neurodegeneration0.58221967
136MP0002064_seizures0.57274763
137MP0009046_muscle_twitch0.56454076
138MP0004742_abnormal_vestibular_system0.56352534
139MP0008874_decreased_physiological_sensi0.55853480
140MP0005174_abnormal_tail_pigmentation0.55543027
141MP0001293_anophthalmia0.54363043
142MP0004147_increased_porphyrin_level0.54064953
143MP0003634_abnormal_glial_cell0.53402374
144MP0003693_abnormal_embryo_hatching0.52962103
145MP0001270_distended_abdomen0.51431572
146MP0006276_abnormal_autonomic_nervous0.50942704
147MP0009745_abnormal_behavioral_response0.50186510
148MP0005423_abnormal_somatic_nervous0.49421325
149MP0004133_heterotaxia0.48797687
150MP0003633_abnormal_nervous_system0.48173908
151MP0004484_altered_response_of0.47901413
152MP0002295_abnormal_pulmonary_circulatio0.47796622
153MP0001963_abnormal_hearing_physiology0.47760605
154MP0002067_abnormal_sensory_capabilities0.47578065
155MP0000538_abnormal_urinary_bladder0.45766077
156MP0002938_white_spotting0.45690691
157MP0010234_abnormal_vibrissa_follicle0.45118966
158MP0003879_abnormal_hair_cell0.44202288
159MP0010030_abnormal_orbit_morphology0.44127634
160MP0000026_abnormal_inner_ear0.43961246
161MP0004145_abnormal_muscle_electrophysio0.43152125
162MP0004510_myositis0.41678275
163MP0003861_abnormal_nervous_system0.40979103
164MP0005195_abnormal_posterior_eye0.40886339
165MP0000534_abnormal_ureter_morphology0.39473270
166MP0005165_increased_susceptibility_to0.36679652
167MP0001501_abnormal_sleep_pattern0.35802233
168MP0002751_abnormal_autonomic_nervous0.34289977
169MP0000049_abnormal_middle_ear0.34080693
170MP0006035_abnormal_mitochondrial_morpho0.32451509
171MP0005058_abnormal_lysosome_morphology0.32010417
172MP0002066_abnormal_motor_capabilities/c0.31905267
173MP0003943_abnormal_hepatobiliary_system0.31407753
174MP0000955_abnormal_spinal_cord0.30419699
175MP0003646_muscle_fatigue0.29330671
176MP0005365_abnormal_bile_salt0.29279835
177MP0006036_abnormal_mitochondrial_physio0.29162356
178MP0000631_abnormal_neuroendocrine_gland0.29112820
179MP0004782_abnormal_surfactant_physiolog0.29041287

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)8.74532745
2Retinal dysplasia (HP:0007973)7.36519031
3Methylmalonic aciduria (HP:0012120)6.95798429
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.45405883
5Abnormal ciliary motility (HP:0012262)6.42951569
6Abnormality of macular pigmentation (HP:0008002)6.34208352
7Abnormal respiratory motile cilium physiology (HP:0012261)6.21075099
8Abnormal respiratory motile cilium morphology (HP:0005938)6.18840747
9Abnormal respiratory epithelium morphology (HP:0012253)6.18840747
10Limb dystonia (HP:0002451)5.88862418
11Bifid tongue (HP:0010297)5.76570561
12Molar tooth sign on MRI (HP:0002419)5.46875586
13Abnormality of midbrain morphology (HP:0002418)5.46875586
14Rhinitis (HP:0012384)5.19008116
15Palpitations (HP:0001962)5.10437862
16Dysphonia (HP:0001618)4.56207215
17Upper limb muscle weakness (HP:0003484)4.51293917
18Atonic seizures (HP:0010819)4.15148576
19Abolished electroretinogram (ERG) (HP:0000550)4.02930717
20Torticollis (HP:0000473)3.95932630
21Anosmia (HP:0000458)3.93678840
22Gait imbalance (HP:0002141)3.81817457
23Congenital primary aphakia (HP:0007707)3.74878099
24Unsteady gait (HP:0002317)3.69971478
25Hand muscle atrophy (HP:0009130)3.67187558
26Bony spicule pigmentary retinopathy (HP:0007737)3.61934471
27Nephrogenic diabetes insipidus (HP:0009806)3.60957489
28Medial flaring of the eyebrow (HP:0010747)3.55058820
29Syncope (HP:0001279)3.53167351
30Absent rod-and cone-mediated responses on ERG (HP:0007688)3.52225848
31Distal upper limb amyotrophy (HP:0007149)3.39202599
32Upper limb amyotrophy (HP:0009129)3.39202599
33Absent/shortened dynein arms (HP:0200106)3.35430308
34Dynein arm defect of respiratory motile cilia (HP:0012255)3.35430308
35Craniofacial dystonia (HP:0012179)3.32826523
36Bronchiectasis (HP:0002110)3.25846016
37Postaxial hand polydactyly (HP:0001162)3.24434571
38Hyperglycinemia (HP:0002154)3.23051550
39Synostosis involving the elbow (HP:0003938)3.21418960
40Humeroradial synostosis (HP:0003041)3.21418960
41Hypothermia (HP:0002045)3.20398487
42Reduced subcutaneous adipose tissue (HP:0003758)3.15585067
43Chronic sinusitis (HP:0011109)3.14434237
44Prolonged neonatal jaundice (HP:0006579)3.10686552
45Occipital encephalocele (HP:0002085)3.10132462
46Poor coordination (HP:0002370)3.08306906
47Increased serum pyruvate (HP:0003542)3.07334809
48Adrenal hypoplasia (HP:0000835)3.06339266
49Premature rupture of membranes (HP:0001788)3.06208462
50Chronic hepatic failure (HP:0100626)3.05528397
51Focal dystonia (HP:0004373)3.04858852
52Abnormality of liposaccharide metabolism (HP:0010968)3.04736223
53Abnormality of glycosphingolipid metabolism (HP:0004343)3.04736223
54Abnormality of glycolipid metabolism (HP:0010969)3.04736223
55Abnormality of glycolysis (HP:0004366)3.04391748
56Osteolytic defects of the hand bones (HP:0009699)3.04359875
57Osteolytic defects of the phalanges of the hand (HP:0009771)3.04359875
58Dicarboxylic aciduria (HP:0003215)3.04297185
59Abnormality of dicarboxylic acid metabolism (HP:0010995)3.04297185
60Pancreatic fibrosis (HP:0100732)2.97531692
61Glucose intolerance (HP:0000833)2.96613548
62Severe visual impairment (HP:0001141)2.96064403
63True hermaphroditism (HP:0010459)2.96030110
64Chronic bronchitis (HP:0004469)2.92596855
65Vaginal atresia (HP:0000148)2.91421733
66Renal hypoplasia (HP:0000089)2.87325288
67Febrile seizures (HP:0002373)2.79742109
68Genital tract atresia (HP:0001827)2.76650676
69Abnormality of dentin (HP:0010299)2.75281218
70Pili torti (HP:0003777)2.74901555
71Abnormality of placental membranes (HP:0011409)2.68122225
72Amniotic constriction ring (HP:0009775)2.68122225
73Hypophosphatemia (HP:0002148)2.67764044
74Decreased central vision (HP:0007663)2.67644215
75Supernumerary spleens (HP:0009799)2.67380220
76Poikilocytosis (HP:0004447)2.66126243
77Absence seizures (HP:0002121)2.60791625
78Myokymia (HP:0002411)2.55135922
79Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.54563142
80Vertebral compression fractures (HP:0002953)2.54025414
81Pheochromocytoma (HP:0002666)2.52642898
82Prolonged QT interval (HP:0001657)2.49657967
83Hypoalphalipoproteinemia (HP:0003233)2.48970398
84Abnormality of the distal phalanges of the toes (HP:0010182)2.48941117
85Distal lower limb muscle weakness (HP:0009053)2.48788937
86Conjunctival hamartoma (HP:0100780)2.47731818
87Rough bone trabeculation (HP:0100670)2.47218969
88Abnormality of sodium homeostasis (HP:0010931)2.46948947
89Multiple lipomas (HP:0001012)2.45872425
90Insulin resistance (HP:0000855)2.41422061
91Neuroendocrine neoplasm (HP:0100634)2.41326596
92Entropion (HP:0000621)2.39522650
93Hyperacusis (HP:0010780)2.37130723
94Complete atrioventricular canal defect (HP:0001674)2.36494044
95Median cleft lip (HP:0000161)2.36302390
96Short nail (HP:0001799)2.35238326
97Nasal polyposis (HP:0100582)2.34166527
98Bone cyst (HP:0012062)2.30864075
99Diaphragmatic weakness (HP:0009113)2.29728493
100Type I transferrin isoform profile (HP:0003642)2.27304280
101Respiratory failure (HP:0002878)2.26226189
102Oculomotor apraxia (HP:0000657)2.25283794
103Distal lower limb amyotrophy (HP:0008944)2.25262319
104Hypertriglyceridemia (HP:0002155)2.24642786
105Aplasia/Hypoplasia of the lens (HP:0008063)2.24136431
106Increased connective tissue (HP:0009025)2.21116294
107Hepatosplenomegaly (HP:0001433)2.20626551
108Tetraparesis (HP:0002273)2.20351725
109Recurrent sinusitis (HP:0011108)2.18170203
110Cystic liver disease (HP:0006706)2.17358485
111Abnormal biliary tract physiology (HP:0012439)2.15904529
112Bile duct proliferation (HP:0001408)2.15904529
113Vacuolated lymphocytes (HP:0001922)2.15509797
114Microglossia (HP:0000171)2.11499561
115Delayed CNS myelination (HP:0002188)2.08888890
116Sudden death (HP:0001699)2.07897145
117Lactic acidosis (HP:0003128)2.07435183
118Abnormal trabecular bone morphology (HP:0100671)2.07211571
119Abnormal hair laboratory examination (HP:0003328)2.06719409
120Pancreatic cysts (HP:0001737)2.06102013
121Retinitis pigmentosa (HP:0000510)2.03397989
122Central scotoma (HP:0000603)2.02806135
123Insulin-resistant diabetes mellitus (HP:0000831)2.02159963
124Xerostomia (HP:0000217)2.01956301
125Nephronophthisis (HP:0000090)2.00557129
126Overriding aorta (HP:0002623)2.00500505
127Congenital hepatic fibrosis (HP:0002612)1.99382093
128Abnormality of the vocal cords (HP:0008777)1.97372318
129Atrioventricular canal defect (HP:0006695)1.96758619
130Constricted visual fields (HP:0001133)1.96345857
131Confusion (HP:0001289)1.95900888
132Dysostosis multiplex (HP:0000943)1.95821482
133Abnormality of permanent molar morphology (HP:0011071)1.95491830
134Abnormality of the dental root (HP:0006486)1.95491830
135Taurodontia (HP:0000679)1.95491830
136Acanthosis nigricans (HP:0000956)1.93404902
137Axonal loss (HP:0003447)1.92887807
138Sparse eyelashes (HP:0000653)1.92792050
139Growth hormone excess (HP:0000845)1.92575965
140Decreased subcutaneous fat (HP:0001002)1.91517102
141Abnormal glucose tolerance (HP:0001952)1.91180833
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.88810845
143Dialeptic seizures (HP:0011146)1.87870271
144Vascular calcification (HP:0004934)1.87553568
145Hypertensive crisis (HP:0100735)1.87512208
146Trismus (HP:0000211)1.86920256
147Interstitial pulmonary disease (HP:0006530)1.86540326
148Loss of speech (HP:0002371)1.83425924
149Abnormality of the nasal mucosa (HP:0000433)1.83344753
150Abnormality of alanine metabolism (HP:0010916)1.83169617
151Hyperalaninemia (HP:0003348)1.83169617
152Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83169617
153Nonimmune hydrops fetalis (HP:0001790)1.83166509
154Abnormality of molar morphology (HP:0011070)1.82608445
155Abnormality of molar (HP:0011077)1.82608445
156Insomnia (HP:0100785)1.81878897
157Abnormal protein glycosylation (HP:0012346)1.81627389
158Abnormal glycosylation (HP:0012345)1.81627389
159Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81627389
160Abnormal protein N-linked glycosylation (HP:0012347)1.81627389
161Attenuation of retinal blood vessels (HP:0007843)1.80228490
162Abnormalities of placenta or umbilical cord (HP:0001194)1.79184094
163Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79091310
164Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79091310
165Flat cornea (HP:0007720)1.78366723
166Upper motor neuron abnormality (HP:0002127)1.78325051
167Hyperglycinuria (HP:0003108)1.76964391
168Hyperhidrosis (HP:0000975)1.76381484
169Cerebral hemorrhage (HP:0001342)1.76332176
170Toxemia of pregnancy (HP:0100603)1.76170088
171Tubulointerstitial nephritis (HP:0001970)1.75609874
172Elfin facies (HP:0004428)1.75496637
173Aganglionic megacolon (HP:0002251)1.75292741
174Recurrent otitis media (HP:0000403)1.75209312
175Facial cleft (HP:0002006)1.75068889
176Myocardial infarction (HP:0001658)1.74602163
177Left ventricular hypertrophy (HP:0001712)1.74310096
178Primary atrial arrhythmia (HP:0001692)1.73352438
179Absent eyebrow (HP:0002223)1.73152561
180Aplasia involving bones of the upper limbs (HP:0009823)1.72393761
181Aplasia of the phalanges of the hand (HP:0009802)1.72393761
182Aplasia involving bones of the extremities (HP:0009825)1.72393761
183Decreased testicular size (HP:0008734)1.71646696
184Achilles tendon contracture (HP:0001771)1.70627407
185Abnormality of polysaccharide metabolism (HP:0011012)1.69400876
186Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69400876
187Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69400876
188Abnormality of the dental pulp (HP:0006479)1.68976012
189Narrow forehead (HP:0000341)1.65403163
190Amyloidosis (HP:0011034)1.65307201
191Hydroureter (HP:0000072)1.63202826
192Bradycardia (HP:0001662)1.63076925
193Supraventricular tachycardia (HP:0004755)1.61797120
194Agitation (HP:0000713)1.61734161
195Abnormality of the renal medulla (HP:0100957)1.61578293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG16.28996770
2PHKG26.28996770
3MAPK155.15930228
4NME24.29013261
5EPHA24.28458827
6TESK24.11258782
7VRK23.73050474
8CDK83.69431807
9TESK13.40158415
10MST1R3.18272769
11NUAK13.16533395
12TRIB33.14088853
13LIMK12.97099194
14SIK22.89714901
15CAMK2D2.61500480
16BUB12.59078795
17CAMK2B2.57275667
18PAK32.50171958
19MOS2.45966645
20MST42.35868579
21STK102.33977386
22ARAF2.26915921
23CAMK1G2.23063168
24ILK2.21457165
25IRAK32.20306632
26CAMKK22.14033301
27CAMK1D2.12519214
28CAMK2G2.09586866
29STK241.97757605
30ERBB31.91207011
31CSNK1A1L1.81502331
32DAPK21.70057448
33TGFBR21.66934609
34SMG11.64204453
35TAOK21.62209296
36GRK71.59929685
37PAK41.57584758
38CSNK1G31.54395454
39RIPK11.51280832
40ICK1.41830337
41ERN11.35607219
42CSNK1G11.35563466
43CSNK1G21.33860470
44STK161.33155013
45MAP3K121.29771419
46SCYL21.26488381
47PRKCG1.24209895
48SIK11.22704034
49FRK1.20302840
50DYRK31.20019635
51MAP3K31.17850790
52PBK1.15603866
53ABL21.15251097
54HIPK21.14545689
55MET1.13165454
56PTK21.10802424
57CDK191.05364321
58GRK60.98936861
59CAMKK10.97516548
60PIM20.96760219
61KDR0.95036133
62MAPKAPK30.91592917
63DAPK10.85713100
64LRRK20.85219983
65EPHB20.84206848
66PRKCI0.81678087
67CAMK2A0.81161906
68ERBB40.80912987
69MAP3K80.77932433
70AURKA0.77847588
71GRK50.77371144
72EIF2AK20.75515769
73RPS6KA20.75498594
74MAP2K70.74361589
75TBK10.73934813
76EPHB10.72246970
77CCNB10.71912847
78MAPK70.71450929
79STK390.71445162
80STK110.70544393
81EIF2AK10.70244715
82EEF2K0.69264843
83CDK120.69259943
84MAP3K110.67991081
85ZAK0.67640710
86TAF10.66951197
87CDK30.66576893
88MAP3K20.62226024
89DYRK1B0.61375030
90SGK2230.59685874
91SGK4940.59685874
92PAK10.59394888
93BRSK10.59138389
94MAP3K100.58095200
95VRK10.58018028
96MELK0.57686506
97MAP2K30.56919895
98MINK10.55925678
99BCKDK0.54064452
100MAP3K40.52467196
101PRPF4B0.52157248
102MYLK0.50160837
103DAPK30.48192883
104PNCK0.47002666
105NME10.45661768
106CAMK40.45374189
107MARK20.44086983
108IRAK10.44042280
109NEK10.42711971
110PRKG20.42382187
111DYRK1A0.41692593
112STK40.40774341
113FER0.40542968
114PRKCZ0.40268469
115PRKAA20.39867867
116AKT20.39301005
117ROCK20.39175837
118CHEK20.38546344
119RAF10.38327315
120STK380.38318216
121PLK20.37447514
122CLK10.37244047
123BRAF0.36799431
124CDK50.36759741
125BMX0.35366827
126PLK10.34482740
127CAMK10.33407904
128CDK70.33257920
129CDK140.33092663
130CDK90.32155959
131PRKCQ0.30588576
132PRKD10.30277028
133RPS6KA50.30161262
134ADRBK10.30040750
135PRKD20.29757205
136CDK11A0.29078109
137PRKCE0.28579687
138AURKB0.28324221
139SGK20.27673385
140CDK150.27353437
141MUSK0.26490035
142MAPKAPK20.26074862
143CDK180.25630865
144LATS20.25173571
145LMTK20.24830296
146RPS6KA40.24819467
147MAP2K40.24761311
148CSF1R0.24626144
149PDPK10.23939519
150FYN0.23617829
151AKT30.23615560
152MAPK100.22695485
153NEK20.22615194
154PTK2B0.22576974
155CASK0.22532261
156MARK10.22305220
157FGFR20.22240582
158MARK30.21936173
159NLK0.20634266
160STK38L0.20368062
161CSK0.19565903
162TTK0.19528199
163MAP3K70.18560827
164CSNK1A10.18061863
165TTN0.17833262
166PRKG10.17800719
167PRKCA0.17108133
168PRKACA0.16919083
169NTRK20.16275325
170PRKACG0.15779491

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.37254774
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.29453304
3Mismatch repair_Homo sapiens_hsa034302.89598475
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.89564272
5DNA replication_Homo sapiens_hsa030302.57055648
6Carbon metabolism_Homo sapiens_hsa012002.50668481
7Nucleotide excision repair_Homo sapiens_hsa034202.50230413
8Base excision repair_Homo sapiens_hsa034102.30394049
9Phototransduction_Homo sapiens_hsa047442.18570443
10Olfactory transduction_Homo sapiens_hsa0474012.2222530
11Galactose metabolism_Homo sapiens_hsa000521.97793615
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.84361012
13Ribosome_Homo sapiens_hsa030101.82980926
14Pyrimidine metabolism_Homo sapiens_hsa002401.81898983
15Taste transduction_Homo sapiens_hsa047421.76582062
16Circadian entrainment_Homo sapiens_hsa047131.71582723
17Morphine addiction_Homo sapiens_hsa050321.70135524
18Biosynthesis of amino acids_Homo sapiens_hsa012301.65846347
19Insulin secretion_Homo sapiens_hsa049111.60997143
20Pentose phosphate pathway_Homo sapiens_hsa000301.58270158
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53780037
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53455397
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.52419890
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49295944
25Dopaminergic synapse_Homo sapiens_hsa047281.44253030
26cAMP signaling pathway_Homo sapiens_hsa040241.44201257
27Gastric acid secretion_Homo sapiens_hsa049711.43812912
28Glutamatergic synapse_Homo sapiens_hsa047241.41436468
29Folate biosynthesis_Homo sapiens_hsa007901.40997101
30Fructose and mannose metabolism_Homo sapiens_hsa000511.39184645
31Bile secretion_Homo sapiens_hsa049761.29708961
32Cholinergic synapse_Homo sapiens_hsa047251.28966170
33Salivary secretion_Homo sapiens_hsa049701.28719621
34RNA polymerase_Homo sapiens_hsa030201.28708178
35GABAergic synapse_Homo sapiens_hsa047271.27052430
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25373258
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25009897
38Apoptosis_Homo sapiens_hsa042101.24445954
39Lysosome_Homo sapiens_hsa041421.18231042
40Homologous recombination_Homo sapiens_hsa034401.16566747
41Histidine metabolism_Homo sapiens_hsa003401.14067723
42Ovarian steroidogenesis_Homo sapiens_hsa049131.13489153
43Vibrio cholerae infection_Homo sapiens_hsa051101.12657078
44Thyroid hormone synthesis_Homo sapiens_hsa049181.12514752
45Fatty acid biosynthesis_Homo sapiens_hsa000611.11477740
46Cell cycle_Homo sapiens_hsa041101.10437698
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06414112
48Glutathione metabolism_Homo sapiens_hsa004801.04624476
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03424529
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00138173
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99086830
52Parkinsons disease_Homo sapiens_hsa050120.98513712
53Other glycan degradation_Homo sapiens_hsa005110.97746325
54Bladder cancer_Homo sapiens_hsa052190.97346827
55beta-Alanine metabolism_Homo sapiens_hsa004100.96522420
56Calcium signaling pathway_Homo sapiens_hsa040200.96473768
57Renin secretion_Homo sapiens_hsa049240.95129726
58Synaptic vesicle cycle_Homo sapiens_hsa047210.95010797
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93768312
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91877573
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90823435
62GnRH signaling pathway_Homo sapiens_hsa049120.90177951
63Glucagon signaling pathway_Homo sapiens_hsa049220.88186339
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87592608
65Alcoholism_Homo sapiens_hsa050340.87562009
66Amphetamine addiction_Homo sapiens_hsa050310.87051632
67Estrogen signaling pathway_Homo sapiens_hsa049150.85521670
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84445405
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84260867
70Shigellosis_Homo sapiens_hsa051310.82911790
71p53 signaling pathway_Homo sapiens_hsa041150.81899943
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81819246
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81033083
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78641978
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78238061
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76984199
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74495790
78Phenylalanine metabolism_Homo sapiens_hsa003600.74278729
79Fatty acid elongation_Homo sapiens_hsa000620.72487400
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70078928
81Cardiac muscle contraction_Homo sapiens_hsa042600.69423467
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68951451
83Melanogenesis_Homo sapiens_hsa049160.68867263
84Sphingolipid metabolism_Homo sapiens_hsa006000.68561860
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.68095501
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67601072
87Alzheimers disease_Homo sapiens_hsa050100.67109667
88Gap junction_Homo sapiens_hsa045400.66771311
89Viral myocarditis_Homo sapiens_hsa054160.66589960
90Oxidative phosphorylation_Homo sapiens_hsa001900.64437339
91Long-term potentiation_Homo sapiens_hsa047200.64166168
92Oxytocin signaling pathway_Homo sapiens_hsa049210.61962543
93Basal transcription factors_Homo sapiens_hsa030220.59358691
94Pancreatic secretion_Homo sapiens_hsa049720.58482501
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58109023
96Epstein-Barr virus infection_Homo sapiens_hsa051690.58089069
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57876742
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.57863663
99Collecting duct acid secretion_Homo sapiens_hsa049660.57224230
100ABC transporters_Homo sapiens_hsa020100.56516056
101Small cell lung cancer_Homo sapiens_hsa052220.56182075
102Pyruvate metabolism_Homo sapiens_hsa006200.55876713
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55688147
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54613508
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54390465
106Nitrogen metabolism_Homo sapiens_hsa009100.52506785
107Fanconi anemia pathway_Homo sapiens_hsa034600.52476305
108Metabolic pathways_Homo sapiens_hsa011000.51688001
109Hematopoietic cell lineage_Homo sapiens_hsa046400.51371769
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.50285588
111Serotonergic synapse_Homo sapiens_hsa047260.49432812
112Cocaine addiction_Homo sapiens_hsa050300.49036437
113Endocytosis_Homo sapiens_hsa041440.48106451
114Dilated cardiomyopathy_Homo sapiens_hsa054140.48101007
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47012867
116Viral carcinogenesis_Homo sapiens_hsa052030.46647245
117Rap1 signaling pathway_Homo sapiens_hsa040150.46147705
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.46079771
119RNA degradation_Homo sapiens_hsa030180.44247292
120Huntingtons disease_Homo sapiens_hsa050160.43786701
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43382308
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43258778
123Legionellosis_Homo sapiens_hsa051340.42311946
124Propanoate metabolism_Homo sapiens_hsa006400.41652496
125Sulfur metabolism_Homo sapiens_hsa009200.41398816
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40898536
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.40455648
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40026736
129Insulin signaling pathway_Homo sapiens_hsa049100.38958240
130Sulfur relay system_Homo sapiens_hsa041220.38517704
131Notch signaling pathway_Homo sapiens_hsa043300.37728406
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.37333436
133N-Glycan biosynthesis_Homo sapiens_hsa005100.36779108
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36568000
135Oocyte meiosis_Homo sapiens_hsa041140.36097920
136Arachidonic acid metabolism_Homo sapiens_hsa005900.35411456
137Salmonella infection_Homo sapiens_hsa051320.34910290
138Purine metabolism_Homo sapiens_hsa002300.34864896
139Chemical carcinogenesis_Homo sapiens_hsa052040.33484555
140Glioma_Homo sapiens_hsa052140.32457257
141Nicotine addiction_Homo sapiens_hsa050330.31047848
142Tyrosine metabolism_Homo sapiens_hsa003500.29851546
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29804610
144Pancreatic cancer_Homo sapiens_hsa052120.29682274
145Systemic lupus erythematosus_Homo sapiens_hsa053220.29630572
146TGF-beta signaling pathway_Homo sapiens_hsa043500.29530262
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29399828
148Axon guidance_Homo sapiens_hsa043600.29281287
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28339162
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27248645
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.27040105
152Prion diseases_Homo sapiens_hsa050200.26560379
153Ras signaling pathway_Homo sapiens_hsa040140.26538667
154Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26036326
155Neurotrophin signaling pathway_Homo sapiens_hsa047220.25795405
156TNF signaling pathway_Homo sapiens_hsa046680.25285934
157Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25152907
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23643805
159Primary bile acid biosynthesis_Homo sapiens_hsa001200.23562256
160Thyroid cancer_Homo sapiens_hsa052160.23111759
161Steroid hormone biosynthesis_Homo sapiens_hsa001400.22907033
162Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22754296
163Starch and sucrose metabolism_Homo sapiens_hsa005000.22741044
164Chemokine signaling pathway_Homo sapiens_hsa040620.22717392
165Toll-like receptor signaling pathway_Homo sapiens_hsa046200.21170013
166Cysteine and methionine metabolism_Homo sapiens_hsa002700.20752325
167Chronic myeloid leukemia_Homo sapiens_hsa052200.20596700
168Amoebiasis_Homo sapiens_hsa051460.19629802
169Peroxisome_Homo sapiens_hsa041460.19460387
170Phagosome_Homo sapiens_hsa041450.19280779
171One carbon pool by folate_Homo sapiens_hsa006700.18824948
172Pertussis_Homo sapiens_hsa051330.17366873
173Non-homologous end-joining_Homo sapiens_hsa034500.16682806
174RNA transport_Homo sapiens_hsa030130.16311328
175Mineral absorption_Homo sapiens_hsa049780.16143479
176Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14228260
177AMPK signaling pathway_Homo sapiens_hsa041520.13781914
178HTLV-I infection_Homo sapiens_hsa051660.12576436

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »