S100A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.42942730
2hemidesmosome assembly (GO:0031581)5.31629118
3translational termination (GO:0006415)5.19126361
4cell adhesion mediated by integrin (GO:0033627)4.99511254
5chondrocyte proliferation (GO:0035988)4.82812947
6ribosomal small subunit biogenesis (GO:0042274)4.81878588
7Golgi transport vesicle coating (GO:0048200)4.80063618
8COPI coating of Golgi vesicle (GO:0048205)4.80063618
9mesenchymal-epithelial cell signaling (GO:0060638)4.66576796
10eosinophil chemotaxis (GO:0048245)4.60652613
11skin morphogenesis (GO:0043589)4.51865078
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.47747507
13protein targeting to ER (GO:0045047)4.41682079
14translational elongation (GO:0006414)4.41068749
15regulation of metalloenzyme activity (GO:0048552)4.35468968
16cotranslational protein targeting to membrane (GO:0006613)4.34642802
17regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.30987188
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.23178877
19cellular protein complex disassembly (GO:0043624)4.18920946
20viral life cycle (GO:0019058)4.11339908
21outer ear morphogenesis (GO:0042473)4.11337389
22eosinophil migration (GO:0072677)4.10937099
23protein localization to endoplasmic reticulum (GO:0070972)4.09061787
24positive regulation of osteoblast proliferation (GO:0033690)4.02036781
25positive regulation of endothelial cell apoptotic process (GO:2000353)3.99228570
26protein localization to endosome (GO:0036010)3.91944175
27hypotonic response (GO:0006971)3.91017122
28membrane raft organization (GO:0031579)3.86532435
29regulation of mononuclear cell migration (GO:0071675)3.85494336
30negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.82667748
31endodermal cell differentiation (GO:0035987)3.82216201
32ribosomal small subunit assembly (GO:0000028)3.82070325
33mesodermal cell differentiation (GO:0048333)3.81033416
34protein maturation by protein folding (GO:0022417)3.77721228
35desmosome organization (GO:0002934)3.77339536
36extracellular fibril organization (GO:0043206)3.76660928
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.73162229
38fibril organization (GO:0097435)3.70431576
39collagen fibril organization (GO:0030199)3.63036128
40middle ear morphogenesis (GO:0042474)3.56982500
41regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.55825686
42regulation of tight junction assembly (GO:2000810)3.55732671
43translational initiation (GO:0006413)3.55277228
44metanephric mesenchyme development (GO:0072075)3.54685440
45type B pancreatic cell proliferation (GO:0044342)3.53802606
46regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.53232128
47sequestering of extracellular ligand from receptor (GO:0035581)3.46947304
48protein targeting to membrane (GO:0006612)3.45792313
49plasma membrane repair (GO:0001778)3.45039994
50wound healing, spreading of epidermal cells (GO:0035313)3.44211184
51membrane budding (GO:0006900)3.42602950
52protein complex disassembly (GO:0043241)3.40893449
53wound healing, spreading of cells (GO:0044319)3.31127822
54kidney mesenchyme development (GO:0072074)3.30847150
55cell-substrate junction assembly (GO:0007044)3.25636002
56cellular response to interferon-alpha (GO:0035457)3.25549720
57pattern specification involved in kidney development (GO:0061004)3.20427510
58regulation of integrin-mediated signaling pathway (GO:2001044)3.18760762
59protein retention in ER lumen (GO:0006621)3.16017854
60positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.13102641
61maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.12480341
62muscle cell migration (GO:0014812)3.11775282
63macromolecular complex disassembly (GO:0032984)3.11357690
64negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.09883509
65protein localization to cell surface (GO:0034394)3.08702019
66pinocytosis (GO:0006907)3.07453076
67macrophage chemotaxis (GO:0048246)3.05935830
68negative regulation of leukocyte chemotaxis (GO:0002689)3.05713576
69negative regulation of T cell receptor signaling pathway (GO:0050860)3.05491242
70mesenchymal cell proliferation (GO:0010463)3.05147857
71positive regulation of actin filament depolymerization (GO:0030836)3.05013390
72vesicle fusion (GO:0006906)3.02993559
73peptidyl-proline hydroxylation (GO:0019511)3.01071031
74lens fiber cell development (GO:0070307)2.96482740
75positive regulation of pseudopodium assembly (GO:0031274)2.94168579
76protein heterotrimerization (GO:0070208)2.92652357
77cellular copper ion homeostasis (GO:0006878)2.89760290
78negative regulation of nitric oxide biosynthetic process (GO:0045019)2.89751198
79myeloid cell homeostasis (GO:0002262)2.88783292
80endothelial cell morphogenesis (GO:0001886)2.88426325
81regulation of interleukin-8 secretion (GO:2000482)2.88013202
82negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.83488085
83regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.83359222
84regulation of extracellular matrix disassembly (GO:0010715)2.83011799
85hippo signaling (GO:0035329)2.82457246
86positive regulation of macrophage activation (GO:0043032)2.81480586
87regulation of early endosome to late endosome transport (GO:2000641)2.80627442
88positive regulation of Cdc42 GTPase activity (GO:0043089)2.79863493
89apoptotic cell clearance (GO:0043277)2.78863433
90cellular response to vitamin D (GO:0071305)2.77637654
91cellular response to vitamin (GO:0071295)2.76262382
92embryonic cranial skeleton morphogenesis (GO:0048701)2.76222883
93hepatocyte apoptotic process (GO:0097284)2.75561988
94positive regulation of epithelial to mesenchymal transition (GO:0010718)2.74053084
95atrioventricular valve morphogenesis (GO:0003181)2.73335796
96protein targeting to plasma membrane (GO:0072661)2.70582371
97actin filament depolymerization (GO:0030042)2.69806743
98epithelial cell-cell adhesion (GO:0090136)2.69204059
99ribosomal large subunit biogenesis (GO:0042273)2.67683541
100negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.67604285
101regulation of monocyte chemotaxis (GO:0090025)2.66108425
102regulation of chemokine secretion (GO:0090196)2.64823069
103negative regulation of fatty acid transport (GO:2000192)2.64776624
104ncRNA 3-end processing (GO:0043628)2.63256624
105negative regulation of glycoprotein metabolic process (GO:1903019)2.61405102
106negative regulation of chondrocyte differentiation (GO:0032331)2.60849583
107virion attachment to host cell (GO:0019062)2.60405435
108adhesion of symbiont to host cell (GO:0044650)2.60405435
109substrate-dependent cell migration (GO:0006929)2.60397077
110mesenchyme morphogenesis (GO:0072132)2.60240358
111nuclear envelope reassembly (GO:0031468)2.59076196
112mitotic nuclear envelope reassembly (GO:0007084)2.59076196
113regulation of pseudopodium assembly (GO:0031272)2.58252170
114cellular response to zinc ion (GO:0071294)2.58244109
115regulation of histone phosphorylation (GO:0033127)2.57789136
116response to progesterone (GO:0032570)2.57235306
117keratinocyte proliferation (GO:0043616)2.56875093
118extracellular matrix disassembly (GO:0022617)2.56335863
119collagen metabolic process (GO:0032963)2.56243614
120positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.55574672
121platelet aggregation (GO:0070527)2.53703157
122positive chemotaxis (GO:0050918)2.53078850
123branching involved in salivary gland morphogenesis (GO:0060445)2.52652000
124stress fiber assembly (GO:0043149)2.51026493
125positive regulation of vesicle fusion (GO:0031340)2.50300218
126positive regulation of chemokine secretion (GO:0090197)2.50184453
127epithelial to mesenchymal transition (GO:0001837)2.50002730
128regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.49378133
129positive regulation of blood vessel endothelial cell migration (GO:0043536)2.48524468
130retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.48431790
131GDP-mannose metabolic process (GO:0019673)2.47891999
132intermediate filament organization (GO:0045109)2.47355872
133branch elongation of an epithelium (GO:0060602)2.47353051
134virion assembly (GO:0019068)2.45629756
135regulation of membrane protein ectodomain proteolysis (GO:0051043)2.45236697
136dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.45176480
137wound healing (GO:0042060)2.45165387
138neuron projection extension involved in neuron projection guidance (GO:1902284)2.45119304
139axon extension involved in axon guidance (GO:0048846)2.45119304
140pyrimidine nucleoside salvage (GO:0043097)2.44555747
141pyrimidine-containing compound salvage (GO:0008655)2.44555747
142endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.44381369
143negative regulation of anoikis (GO:2000811)2.44306235
144positive regulation of extracellular matrix organization (GO:1903055)2.43592042
145regulation of heart morphogenesis (GO:2000826)2.43368455
146substrate adhesion-dependent cell spreading (GO:0034446)2.41820711
147mature B cell differentiation involved in immune response (GO:0002313)2.41503184
148barbed-end actin filament capping (GO:0051016)2.40823197
149establishment of protein localization to membrane (GO:0090150)2.40709594
150negative regulation of ERBB signaling pathway (GO:1901185)2.37295187
151positive regulation of interleukin-8 secretion (GO:2000484)2.37179506
152negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)2.36815035
153fibrinolysis (GO:0042730)2.36393016
154positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.36085936
155negative regulation of nitric-oxide synthase activity (GO:0051001)2.35006159
156endothelial tube morphogenesis (GO:0061154)2.34769356
157morphogenesis of an endothelium (GO:0003159)2.34769356
158autophagic vacuole fusion (GO:0000046)2.34444578
159regulation of anoikis (GO:2000209)2.34411965
160negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.34337925
161extracellular regulation of signal transduction (GO:1900115)2.34036567
162extracellular negative regulation of signal transduction (GO:1900116)2.34036567
163antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.32962640
164antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.32530637
165regulation of apoptotic process involved in morphogenesis (GO:1902337)2.31013657
166cyclooxygenase pathway (GO:0019371)2.30037587
167glomerular epithelial cell development (GO:0072310)2.29149981
168branching involved in mammary gland duct morphogenesis (GO:0060444)2.28356326
169regulation of collagen metabolic process (GO:0010712)2.27389036
170protein hydroxylation (GO:0018126)2.27367963
171regulation of necrotic cell death (GO:0010939)2.26001223
172endothelial cell chemotaxis (GO:0035767)2.25423006
173hyaluronan catabolic process (GO:0030214)2.22177681
174localization within membrane (GO:0051668)2.20842758
175negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.20254454
176adhesion of symbiont to host (GO:0044406)2.19063424
177negative regulation of protein tyrosine kinase activity (GO:0061099)2.16880886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.90253523
2TRIM28_21343339_ChIP-Seq_HEK293_Human6.39937238
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.35726948
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.85021291
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.00215545
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.19290007
7* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.70017710
8SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.64048540
9SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.64048540
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.55835923
11CLOCK_20551151_ChIP-Seq_293T_Human2.54841530
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48479096
13CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.27977602
14CJUN_26792858_Chip-Seq_BT549_Human2.27686961
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.25728575
16* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.18551415
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.13440952
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09363993
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.05059575
20SOX2_20726797_ChIP-Seq_SW620_Human2.03637297
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00929606
22* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.97275469
23* ELK3_25401928_ChIP-Seq_HUVEC_Human1.91277832
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.85507585
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85402377
26* ATF3_27146783_Chip-Seq_COLON_Human1.84930391
27ELK1_22589737_ChIP-Seq_MCF10A_Human1.79850788
28NRF2_20460467_ChIP-Seq_MEFs_Mouse1.78146214
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.78146214
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77940776
31* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74864398
32* BRD4_25478319_ChIP-Seq_HGPS_Human1.74628461
33* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71771547
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.69444028
35* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66015163
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.61720926
37HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.61462941
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.60111584
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59294013
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.59289297
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57853382
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57477524
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.57041889
44* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55887092
45* UBF1/2_26484160_Chip-Seq_HMECs_Human1.53459193
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.52039707
47ZNF263_19887448_ChIP-Seq_K562_Human1.51781211
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.48463243
49* RACK7_27058665_Chip-Seq_MCF-7_Human1.47929577
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44359275
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38485027
52* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.37218115
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.35691566
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35565329
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34264655
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33636471
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.33175018
58* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31893105
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31133490
60* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29885186
61TP53_18474530_ChIP-ChIP_U2OS_Human1.29633954
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28665947
63CDX2_20551321_ChIP-Seq_CACO-2_Human1.27578735
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26033051
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25527083
66* KLF5_25053715_ChIP-Seq_YYC3_Human1.25013716
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24907070
68GATA1_22025678_ChIP-Seq_K562_Human1.23126122
69VDR_21846776_ChIP-Seq_THP-1_Human1.21779074
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20609156
71* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19890300
72* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19829178
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18903515
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16409756
75* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14019248
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.13958818
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.13898808
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.11562142
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11287069
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.10779191
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09679593
82* RUNX1_22412390_ChIP-Seq_EML_Mouse1.09584004
83ELK1_19687146_ChIP-ChIP_HELA_Human1.08592560
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07273948
85AR_21909140_ChIP-Seq_LNCAP_Human1.06466292
86GATA6_25053715_ChIP-Seq_YYC3_Human1.06047470
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05945183
88TP53_22127205_ChIP-Seq_IMR90_Human1.05707560
89EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05279173
90GATA4_25053715_ChIP-Seq_YYC3_Human1.04561193
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04490698
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04447922
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03944101
94* IRF8_27001747_Chip-Seq_BMDM_Mouse1.03408120
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01379431
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99851007
97RXR_22158963_ChIP-Seq_LIVER_Mouse0.99045847
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98755194
99CSB_26484114_Chip-Seq_FIBROBLAST_Human0.98067319
100* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97225469
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96918070
102STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96894481
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96590713
104TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96141365
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96057137
106* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95911760
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94888073
108MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93586012
109* TFEB_21752829_ChIP-Seq_HELA_Human0.93398681
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93352016
111SPI1_23127762_ChIP-Seq_K562_Human0.93028927
112TET1_21451524_ChIP-Seq_MESCs_Mouse0.92614496
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91739702
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91599302
115GATA3_24758297_ChIP-Seq_MCF-7_Human0.91579023
116* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91270420
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90609810
118SPI1_23547873_ChIP-Seq_NB4_Human0.90409730
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90381004
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89118273
121* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88596430
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88204930
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88006373
124ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87776805
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87572356
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86351630
127* TP53_16413492_ChIP-PET_HCT116_Human0.85334574
128* VDR_24763502_ChIP-Seq_THP-1_Human0.84332141
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83979499
130* LXR_22292898_ChIP-Seq_THP-1_Human0.82571936
131* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82254863
132* RUNX1_27514584_Chip-Seq_MCF-7_Human0.80664630
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79452677
134* TP53_23651856_ChIP-Seq_MEFs_Mouse0.77657663
135KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76965907

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.97262066
2MP0003705_abnormal_hypodermis_morpholog4.24862186
3MP0005275_abnormal_skin_tensile4.16952776
4MP0003191_abnormal_cellular_cholesterol3.31389608
5MP0005623_abnormal_meninges_morphology3.02249585
6MP0010352_gastrointestinal_tract_polyps2.68166996
7MP0002877_abnormal_melanocyte_morpholog2.65913921
8MP0010234_abnormal_vibrissa_follicle2.64466135
9MP0006082_CNS_inflammation2.63356962
10MP0003279_aneurysm2.62237812
11MP0005503_abnormal_tendon_morphology2.55387493
12MP0003566_abnormal_cell_adhesion2.51761912
13MP0001958_emphysema2.42840409
14MP0009384_cardiac_valve_regurgitation2.39993478
15MP0005023_abnormal_wound_healing2.39596135
16MP0004272_abnormal_basement_membrane2.26539354
17MP0003091_abnormal_cell_migration2.25852172
18MP0009840_abnormal_foam_cell2.21090307
19MP0002060_abnormal_skin_morphology2.19921315
20MP0005058_abnormal_lysosome_morphology2.16514453
21MP0010030_abnormal_orbit_morphology2.06941317
22MP0009379_abnormal_foot_pigmentation1.96813545
23MP0006054_spinal_hemorrhage1.95570799
24MP0004510_myositis1.91317239
25MP0003806_abnormal_nucleotide_metabolis1.87853207
26MP0005076_abnormal_cell_differentiation1.84829704
27MP0005165_increased_susceptibility_to1.84796697
28MP0000733_abnormal_muscle_development1.72017212
29MP0003453_abnormal_keratinocyte_physiol1.71063897
30MP0000858_altered_metastatic_potential1.69895353
31MP0000750_abnormal_muscle_regeneration1.69417062
32MP0003075_altered_response_to1.65588309
33MP0002282_abnormal_trachea_morphology1.64478426
34MP0009250_abnormal_appendicular_skeleto1.62002452
35MP0005508_abnormal_skeleton_morphology1.60462393
36MP0005257_abnormal_intraocular_pressure1.58751210
37MP0002796_impaired_skin_barrier1.56756975
38MP0005166_decreased_susceptibility_to1.56629384
39MP0001243_abnormal_dermal_layer1.55666196
40MP0000762_abnormal_tongue_morphology1.54685134
41MP0003828_pulmonary_edema1.49416403
42MP0003941_abnormal_skin_development1.46946982
43MP0001542_abnormal_bone_strength1.45963510
44MP0002896_abnormal_bone_mineralization1.44854645
45MP0005501_abnormal_skin_physiology1.44841970
46MP0009053_abnormal_anal_canal1.39472068
47MP0002148_abnormal_hypersensitivity_rea1.39400462
48MP0001299_abnormal_eye_distance/1.38998237
49MP0008260_abnormal_autophagy1.35805065
50MP0009785_altered_susceptibility_to1.33172601
51MP0010368_abnormal_lymphatic_system1.31150911
52MP0000537_abnormal_urethra_morphology1.30640675
53MP0009780_abnormal_chondrocyte_physiolo1.30284812
54MP0005360_urolithiasis1.29399734
55MP0001216_abnormal_epidermal_layer1.29024344
56MP0003950_abnormal_plasma_membrane1.28289904
57MP0001853_heart_inflammation1.27806017
58MP0005451_abnormal_body_composition1.27378567
59MP0000163_abnormal_cartilage_morphology1.25990457
60MP0003300_gastrointestinal_ulcer1.25228950
61MP0002419_abnormal_innate_immunity1.23921140
62MP0005390_skeleton_phenotype1.23892558
63MP0003436_decreased_susceptibility_to1.23276024
64MP0010771_integument_phenotype1.22701402
65MP0008004_abnormal_stomach_pH1.20889112
66MP0001533_abnormal_skeleton_physiology1.20624325
67MP0003329_amyloid_beta_deposits1.20533460
68MP0004858_abnormal_nervous_system1.20140711
69MP0000751_myopathy1.19919628
70MP0002295_abnormal_pulmonary_circulatio1.18457395
71MP0004947_skin_inflammation1.17145416
72MP0003942_abnormal_urinary_system1.16350009
73MP0003448_altered_tumor_morphology1.15978739
74MP0000749_muscle_degeneration1.13880517
75MP0003045_fibrosis1.13787882
76MP0010155_abnormal_intestine_physiology1.13744178
77MP0001849_ear_inflammation1.12548538
78MP0000604_amyloidosis1.11637738
79MP0005464_abnormal_platelet_physiology1.11322720
80MP0003755_abnormal_palate_morphology1.11052469
81MP0001663_abnormal_digestive_system1.10890051
82MP0005025_abnormal_response_to1.09393805
83MP0003303_peritoneal_inflammation1.08818399
84MP0005164_abnormal_response_to1.06574783
85MP0002332_abnormal_exercise_endurance1.05113654
86MP0003724_increased_susceptibility_to1.03606398
87MP0000343_altered_response_to1.03588760
88MP0002933_joint_inflammation1.01353075
89MP0000566_synostosis1.01100985
90MP0002998_abnormal_bone_remodeling0.99091136
91MP0000013_abnormal_adipose_tissue0.98359212
92MP0003795_abnormal_bone_structure0.96756962
93MP0001348_abnormal_lacrimal_gland0.96545820
94MP0002168_other_aberrant_phenotype0.95325392
95MP0000685_abnormal_immune_system0.95255358
96MP0000627_abnormal_mammary_gland0.94496195
97MP0000049_abnormal_middle_ear0.94425473
98MP0000377_abnormal_hair_follicle0.92353683
99MP0000678_abnormal_parathyroid_gland0.92321945
100MP0010678_abnormal_skin_adnexa0.92165312
101MP0002115_abnormal_skeleton_extremities0.92159154
102MP0000490_abnormal_crypts_of0.91767842
103MP0005197_abnormal_uvea_morphology0.91031942
104MP0004883_abnormal_blood_vessel0.89761122
105MP0003385_abnormal_body_wall0.89634966
106MP0009333_abnormal_splenocyte_physiolog0.89225262
107MP0002113_abnormal_skeleton_development0.88941565
108MP0005083_abnormal_biliary_tract0.88509686
109MP0001835_abnormal_antigen_presentation0.87586027
110MP0002177_abnormal_outer_ear0.87137427
111MP0001845_abnormal_inflammatory_respons0.86201292
112MP0001879_abnormal_lymphatic_vessel0.84966489
113MP0000767_abnormal_smooth_muscle0.84345029
114MP0002132_abnormal_respiratory_system0.83217255
115MP0002098_abnormal_vibrissa_morphology0.83037648
116MP0005193_abnormal_anterior_eye0.82862575
117MP0005381_digestive/alimentary_phenotyp0.81865655
118MP0001790_abnormal_immune_system0.81724555
119MP0005387_immune_system_phenotype0.81724555
120MP0002452_abnormal_antigen_presenting0.81526335
121MP0008469_abnormal_protein_level0.81416006
122MP0002234_abnormal_pharynx_morphology0.80933115
123MP0002405_respiratory_system_inflammati0.80033968
124MP0005000_abnormal_immune_tolerance0.79776729
125MP0009764_decreased_sensitivity_to0.79447004
126MP0004185_abnormal_adipocyte_glucose0.78480083
127MP0000428_abnormal_craniofacial_morphol0.78467481
128MP0000681_abnormal_thyroid_gland0.76580387
129MP0002108_abnormal_muscle_morphology0.75912440
130MP0000516_abnormal_urinary_system0.75796315
131MP0005367_renal/urinary_system_phenotyp0.75796315
132MP0000427_abnormal_hair_cycle0.75683489
133MP0001191_abnormal_skin_condition0.74486286
134MP0005595_abnormal_vascular_smooth0.74447223
135MP0005330_cardiomyopathy0.73007654
136MP0000249_abnormal_blood_vessel0.72190388
137MP0001614_abnormal_blood_vessel0.70524017
138MP0009931_abnormal_skin_appearance0.70514245
139MP0000647_abnormal_sebaceous_gland0.69770826
140MP0004808_abnormal_hematopoietic_stem0.68630148
141MP0000534_abnormal_ureter_morphology0.67353769
142MP0001340_abnormal_eyelid_morphology0.66878111
143MP0010307_abnormal_tumor_latency0.65453384
144MP0000467_abnormal_esophagus_morphology0.65018622
145MP0001346_abnormal_lacrimal_gland0.64698868
146MP0000383_abnormal_hair_follicle0.64642297
147MP0003115_abnormal_respiratory_system0.64462364

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.51118516
2Premature rupture of membranes (HP:0001788)6.47516571
3Atrophic scars (HP:0001075)5.12016167
4Reduced subcutaneous adipose tissue (HP:0003758)4.16984316
5Vertebral compression fractures (HP:0002953)3.92949813
6Peritonitis (HP:0002586)3.89942700
7Shallow orbits (HP:0000586)3.77435698
8Fragile skin (HP:0001030)3.64404935
9Abnormality of glycolipid metabolism (HP:0010969)3.56987799
10Abnormality of liposaccharide metabolism (HP:0010968)3.56987799
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.56987799
12Aortic dissection (HP:0002647)3.49992940
13Increased connective tissue (HP:0009025)3.46025360
14Neonatal short-limb short stature (HP:0008921)3.45068199
15Soft skin (HP:0000977)3.44839752
16Ankle contracture (HP:0006466)3.44098936
17Short nail (HP:0001799)3.36007361
18Spinal rigidity (HP:0003306)3.27523989
19Aortic aneurysm (HP:0004942)3.25884039
20Wormian bones (HP:0002645)3.21276815
21Cervical subluxation (HP:0003308)3.20914320
22Increased density of long bones (HP:0006392)3.19735708
23Dilatation of the ascending aorta (HP:0005111)3.19663484
24Fragile nails (HP:0001808)3.18281105
25Abnormality of dentin (HP:0010299)3.12566562
26Osteolytic defects of the hand bones (HP:0009699)3.09772828
27Osteolytic defects of the phalanges of the hand (HP:0009771)3.09772828
28Amyloidosis (HP:0011034)3.08588744
29Glucose intolerance (HP:0000833)3.06227462
30Abnormal hemoglobin (HP:0011902)3.01494580
31Cerebral aneurysm (HP:0004944)2.94454972
32Milia (HP:0001056)2.91207238
33Axonal loss (HP:0003447)2.82975689
34Onycholysis (HP:0001806)2.79022800
35Trismus (HP:0000211)2.75169357
36Cardiovascular calcification (HP:0011915)2.74356391
37Nuclear cataract (HP:0100018)2.68628190
38Blue sclerae (HP:0000592)2.67508925
39Interstitial pulmonary disease (HP:0006530)2.63930022
40Abnormality of the 2nd finger (HP:0004100)2.63784468
41Right ventricular cardiomyopathy (HP:0011663)2.60989698
42Vascular calcification (HP:0004934)2.60454776
43Vascular tortuosity (HP:0004948)2.60210254
44Biconcave vertebral bodies (HP:0004586)2.58579146
45Sparse lateral eyebrow (HP:0005338)2.56717907
46Generalized amyotrophy (HP:0003700)2.54154044
47Distal lower limb muscle weakness (HP:0009053)2.52801341
48Abnormality of the distal phalanges of the toes (HP:0010182)2.43788082
49Dysostosis multiplex (HP:0000943)2.41968926
50Rough bone trabeculation (HP:0100670)2.41493000
51Type 1 muscle fiber predominance (HP:0003803)2.39874809
52Spondylolisthesis (HP:0003302)2.39168798
53Follicular hyperkeratosis (HP:0007502)2.38928311
54Genu recurvatum (HP:0002816)2.38665370
55Distal lower limb amyotrophy (HP:0008944)2.35799900
56Coronal craniosynostosis (HP:0004440)2.34138585
57Spinal cord compression (HP:0002176)2.31861442
58Abnormality of macrophages (HP:0004311)2.28527364
59Elbow flexion contracture (HP:0002987)2.27451637
60Vacuolated lymphocytes (HP:0001922)2.22285749
61Wrist flexion contracture (HP:0001239)2.21297497
62Arterial tortuosity (HP:0005116)2.20063556
63Natal tooth (HP:0000695)2.16639271
64Abnormality of the nasal mucosa (HP:0000433)2.15827060
65Achilles tendon contracture (HP:0001771)2.15751027
66Abnormality of the acetabulum (HP:0003170)2.15048003
67Abnormal glucose tolerance (HP:0001952)2.14463529
68Abnormality of cells of the erythroid lineage (HP:0012130)2.12992842
69Mitral valve prolapse (HP:0001634)2.12962557
70Pterygium (HP:0001059)2.11592178
71Down-sloping shoulders (HP:0200021)2.09672713
72Mitral regurgitation (HP:0001653)2.08579067
73Broad metatarsal (HP:0001783)2.08127376
74Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.07764481
75Vertebral hypoplasia (HP:0008417)2.07764481
76Coxa vara (HP:0002812)2.07358105
77Syringomyelia (HP:0003396)2.06805065
78Spinal cord lesions (HP:0100561)2.06805065
79Woolly hair (HP:0002224)2.06423571
80Joint stiffness (HP:0001387)2.06183039
81Scapular winging (HP:0003691)2.04681201
82Bladder diverticulum (HP:0000015)2.03065897
83Hyperextensible skin (HP:0000974)2.02764081
84Abnormal delivery (HP:0001787)2.02412553
85Congenital, generalized hypertrichosis (HP:0004540)2.01870649
86Thin bony cortex (HP:0002753)2.00889376
87Alopecia of scalp (HP:0002293)2.00485966
88Deviation of the hallux (HP:0010051)1.99941698
89Beaking of vertebral bodies (HP:0004568)1.98851865
90Nasal polyposis (HP:0100582)1.98712239
91Chin dimple (HP:0010751)1.98366580
92Buphthalmos (HP:0000557)1.97658500
93Nail dystrophy (HP:0008404)1.96920928
94Mildly elevated creatine phosphokinase (HP:0008180)1.96842996
95Neurofibrillary tangles (HP:0002185)1.96424302
96Ulnar bowing (HP:0003031)1.95993336
97Plantar hyperkeratosis (HP:0007556)1.95898161
98Upper limb muscle weakness (HP:0003484)1.95332749
99Difficulty climbing stairs (HP:0003551)1.95188935
100Reticulocytopenia (HP:0001896)1.93956276
101Hand muscle atrophy (HP:0009130)1.93264746
102Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91541821
103Hallux valgus (HP:0001822)1.90655890
104Abnormality of the calcaneus (HP:0008364)1.90653685
105Delayed cranial suture closure (HP:0000270)1.90500032
106Overgrowth (HP:0001548)1.89653852
107Acanthosis nigricans (HP:0000956)1.88262176
108Fused cervical vertebrae (HP:0002949)1.87927569
109Limb-girdle muscle atrophy (HP:0003797)1.87919531
110Hepatosplenomegaly (HP:0001433)1.86452597
111Abnormal trabecular bone morphology (HP:0100671)1.86153883
112Abnormality of the Achilles tendon (HP:0005109)1.85035813
113Thick nail (HP:0001805)1.84934504
114Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83537709
115Abnormality of polysaccharide metabolism (HP:0011012)1.83537709
116Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83537709
117Camptodactyly of toe (HP:0001836)1.81922266
118Aplasia involving bones of the upper limbs (HP:0009823)1.80888222
119Aplasia of the phalanges of the hand (HP:0009802)1.80888222
120Aplasia involving bones of the extremities (HP:0009825)1.80888222
121Mucopolysacchariduria (HP:0008155)1.79967616
122Urinary glycosaminoglycan excretion (HP:0003541)1.79967616
123Entropion (HP:0000621)1.79620800
124Tibial bowing (HP:0002982)1.78971846
125Radial bowing (HP:0002986)1.78573422
126Hypertriglyceridemia (HP:0002155)1.76436776
127Distal upper limb amyotrophy (HP:0007149)1.76230363
128Upper limb amyotrophy (HP:0009129)1.76230363
129Elevated erythrocyte sedimentation rate (HP:0003565)1.76222649
130Lower limb amyotrophy (HP:0007210)1.73844632
131Flat acetabular roof (HP:0003180)1.73761599
132Mitral stenosis (HP:0001718)1.73626719
133Palmoplantar hyperkeratosis (HP:0000972)1.72992438
134Congenital glaucoma (HP:0001087)1.72604260
135Eczematoid dermatitis (HP:0000976)1.71765408
136Abnormality of carpal bone ossification (HP:0006257)1.71531820
137Broad face (HP:0000283)1.71390646
138Bronchomalacia (HP:0002780)1.70740127
139Myocardial infarction (HP:0001658)1.69763047
140Broad hallux (HP:0010055)1.68644739
141Purpura (HP:0000979)1.68384730
142Bradycardia (HP:0001662)1.67507041
143Loss of speech (HP:0002371)1.67219562
144Steatorrhea (HP:0002570)1.63344787
145Prolonged neonatal jaundice (HP:0006579)1.63102980
146Abnormal blistering of the skin (HP:0008066)1.62823610
147Abnormality of complement system (HP:0005339)1.61737972
148Polygenic inheritance (HP:0010982)1.60967745
149Insulin resistance (HP:0000855)1.60930337
150Multiple lipomas (HP:0001012)1.60237110
151Sparse eyelashes (HP:0000653)1.59125801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.47283781
2LATS23.35832748
3TESK13.28942529
4EPHA23.13347632
5MOS3.11428397
6LIMK12.88894963
7TTN2.78814147
8IRAK32.73293592
9PIM22.59012893
10LMTK22.58746029
11MST42.58470171
12TRIB32.57123404
13MKNK22.50050754
14EPHB22.44370426
15LRRK22.44068391
16TESK22.43584761
17PAK22.32206598
18TAOK12.29207313
19ERN12.14006714
20DDR22.12817561
21TRPM72.07578045
22MST1R1.95231691
23RPS6KA41.87669745
24MAP3K121.86936942
25PKN21.81391382
26PAK41.75731154
27ARAF1.73320482
28LATS11.65462177
29BMX1.59623651
30PTK21.51934949
31PAK61.50386470
32ILK1.48426741
33MET1.46622168
34PDGFRA1.44516003
35PTK61.40037849
36FER1.37736482
37STK101.34772806
38NEK91.28785741
39FRK1.19815934
40ERBB31.18544875
41PRPF4B1.17476158
42ROCK21.16984888
43ROCK11.16352451
44PBK1.10422913
45MAP3K31.08426237
46MAP2K11.05332626
47RPS6KB21.04723242
48STK31.02726036
49WNK11.01262207
50PTK2B0.95932241
51MKNK10.95024165
52ZAP700.94264715
53PAK10.92005662
54DMPK0.89877517
55PRKG20.87349820
56PIK3CG0.85558020
57MAP3K10.84227901
58GRK70.83307152
59SIK10.83306061
60MAP2K20.83057412
61SCYL20.78576237
62PAK30.77334272
63CDK60.76311977
64ABL20.74849044
65DYRK1B0.74804132
66VRK20.73814616
67TLK10.73760087
68MAP3K20.72558136
69RIPK10.71905447
70MAP3K50.69636460
71PIK3CA0.69587457
72MAPKAPK20.69281103
73MAP3K80.68344961
74SIK30.67957362
75TYK20.65725646
76STK38L0.65207455
77FGFR10.65050104
78STK380.64990837
79EEF2K0.63881592
80PRKD10.60259549
81NTRK10.59228213
82BLK0.58844798
83MAPKAPK30.58343741
84SMG10.58151909
85DAPK10.57929721
86DAPK30.55950775
87CSK0.55571511
88TGFBR10.55425843
89EPHB10.55159124
90MAP3K60.54207627
91PRKD20.54096703
92CDC42BPA0.53888185
93CAMK2D0.53000792
94AURKB0.50468064
95TBK10.47050996
96INSR0.46848406
97ICK0.46135966
98TGFBR20.44616712
99PDGFRB0.43964314
100KDR0.43257632
101MAP3K110.42884031
102TAOK20.41481643
103CDK140.41466846
104GSK3A0.40694305
105MAPKAPK50.39602828
106MAP3K140.39542727
107ADRBK10.38966275
108BRAF0.38193292
109IRAK40.38040134
110JAK30.36663964
111MAP2K30.36506962
112MYLK0.36328080
113PRKCI0.36236290
114CDK80.36148623
115MARK30.35900668
116SRC0.31887095
117IKBKB0.30905892
118CDK150.30898526
119EGFR0.29755279
120PDPK10.29155737
121ERBB40.28445126
122STK240.28063831
123CDK180.27723251
124MUSK0.27059798
125CDK11A0.26470837
126PHKG20.26119443
127PHKG10.26119443
128CAMK2G0.25833647
129GRK50.25595511
130RET0.25487843
131ABL10.25032932
132FLT30.24912216
133BUB10.23241221
134ERBB20.22773903
135HIPK20.21962483
136BMPR20.21838346
137JAK10.21823816
138MELK0.21512115
139PRKCD0.21422048
140NME10.20379147

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.49129943
2Other glycan degradation_Homo sapiens_hsa005112.93849149
3ECM-receptor interaction_Homo sapiens_hsa045122.92779181
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.79336532
5Bladder cancer_Homo sapiens_hsa052192.76089414
6Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.74163433
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.47914464
8Proteoglycans in cancer_Homo sapiens_hsa052052.44802751
9Focal adhesion_Homo sapiens_hsa045102.31506195
10Adherens junction_Homo sapiens_hsa045202.14205360
11Small cell lung cancer_Homo sapiens_hsa052222.05128250
12Galactose metabolism_Homo sapiens_hsa000521.99063751
13Malaria_Homo sapiens_hsa051441.95766032
14TGF-beta signaling pathway_Homo sapiens_hsa043501.87420788
15Amoebiasis_Homo sapiens_hsa051461.86690945
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.86229419
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.80746581
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80556091
19Shigellosis_Homo sapiens_hsa051311.78563840
20p53 signaling pathway_Homo sapiens_hsa041151.74406263
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.67119479
22Melanoma_Homo sapiens_hsa052181.62793217
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.59765832
24Fructose and mannose metabolism_Homo sapiens_hsa000511.58492038
25Regulation of actin cytoskeleton_Homo sapiens_hsa048101.55676810
26MicroRNAs in cancer_Homo sapiens_hsa052061.53671180
27Chronic myeloid leukemia_Homo sapiens_hsa052201.53570783
28Hippo signaling pathway_Homo sapiens_hsa043901.51559937
29Pentose phosphate pathway_Homo sapiens_hsa000301.50166595
30Salmonella infection_Homo sapiens_hsa051321.47339780
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45836288
32Viral myocarditis_Homo sapiens_hsa054161.41720762
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36323781
34Tight junction_Homo sapiens_hsa045301.32915405
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.27396977
36TNF signaling pathway_Homo sapiens_hsa046681.24184586
37Thyroid cancer_Homo sapiens_hsa052161.24058617
38Rap1 signaling pathway_Homo sapiens_hsa040151.21385302
39Apoptosis_Homo sapiens_hsa042101.20331977
40Toxoplasmosis_Homo sapiens_hsa051451.19628448
41Pertussis_Homo sapiens_hsa051331.18913574
42Phagosome_Homo sapiens_hsa041451.18002785
43Leishmaniasis_Homo sapiens_hsa051401.15901419
44Dilated cardiomyopathy_Homo sapiens_hsa054141.13075123
45Pancreatic cancer_Homo sapiens_hsa052121.12718164
46Platelet activation_Homo sapiens_hsa046111.09874851
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07430963
48Fatty acid elongation_Homo sapiens_hsa000621.04239806
49Glioma_Homo sapiens_hsa052140.99284964
50Mineral absorption_Homo sapiens_hsa049780.98857033
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.97311317
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95751605
53Folate biosynthesis_Homo sapiens_hsa007900.92706934
54HTLV-I infection_Homo sapiens_hsa051660.89481039
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89416521
56Pathways in cancer_Homo sapiens_hsa052000.88775580
57Prion diseases_Homo sapiens_hsa050200.88644824
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88095244
59Viral carcinogenesis_Homo sapiens_hsa052030.87593341
60Influenza A_Homo sapiens_hsa051640.87541460
61Legionellosis_Homo sapiens_hsa051340.86852503
62Tuberculosis_Homo sapiens_hsa051520.86024134
63Glutathione metabolism_Homo sapiens_hsa004800.85573487
64VEGF signaling pathway_Homo sapiens_hsa043700.85493339
65Hematopoietic cell lineage_Homo sapiens_hsa046400.84858907
66Complement and coagulation cascades_Homo sapiens_hsa046100.84414019
67Hepatitis C_Homo sapiens_hsa051600.83562171
68Hepatitis B_Homo sapiens_hsa051610.80360522
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79833782
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79424386
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78737918
72Osteoclast differentiation_Homo sapiens_hsa043800.78329144
73HIF-1 signaling pathway_Homo sapiens_hsa040660.78092052
74Allograft rejection_Homo sapiens_hsa053300.78035371
75Protein export_Homo sapiens_hsa030600.77850802
76Axon guidance_Homo sapiens_hsa043600.76066636
77African trypanosomiasis_Homo sapiens_hsa051430.75617765
78Ras signaling pathway_Homo sapiens_hsa040140.74397535
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73515821
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.73431768
81Autoimmune thyroid disease_Homo sapiens_hsa053200.72886290
82Protein digestion and absorption_Homo sapiens_hsa049740.72278040
83Endocytosis_Homo sapiens_hsa041440.71685778
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71492368
85Proteasome_Homo sapiens_hsa030500.71327552
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68333824
87Staphylococcus aureus infection_Homo sapiens_hsa051500.67992451
88Prostate cancer_Homo sapiens_hsa052150.67214779
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66918927
90Vibrio cholerae infection_Homo sapiens_hsa051100.66482337
91Antigen processing and presentation_Homo sapiens_hsa046120.65200928
92Renal cell carcinoma_Homo sapiens_hsa052110.64973697
93Sulfur metabolism_Homo sapiens_hsa009200.64176788
94Pyrimidine metabolism_Homo sapiens_hsa002400.63573069
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62378136
96Rheumatoid arthritis_Homo sapiens_hsa053230.61437194
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59688103
98Phenylalanine metabolism_Homo sapiens_hsa003600.57877261
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56975106
100Chemical carcinogenesis_Homo sapiens_hsa052040.56743908
101Arachidonic acid metabolism_Homo sapiens_hsa005900.56147490
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.55287697
103Endometrial cancer_Homo sapiens_hsa052130.55085028
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.54922089
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54503201
106Basal cell carcinoma_Homo sapiens_hsa052170.53395106
107Lysosome_Homo sapiens_hsa041420.51678444
108Colorectal cancer_Homo sapiens_hsa052100.50735496
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50526867
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50466023
111Hedgehog signaling pathway_Homo sapiens_hsa043400.50399979
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.50150394
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.49083447
114Measles_Homo sapiens_hsa051620.48743377
115Acute myeloid leukemia_Homo sapiens_hsa052210.47898148
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47711720
117Sulfur relay system_Homo sapiens_hsa041220.44052809
118Wnt signaling pathway_Homo sapiens_hsa043100.44030304
119Starch and sucrose metabolism_Homo sapiens_hsa005000.43770448
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43189407
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42463676
122Graft-versus-host disease_Homo sapiens_hsa053320.41438216
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39651958
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.39594693
125N-Glycan biosynthesis_Homo sapiens_hsa005100.39357295
126Tyrosine metabolism_Homo sapiens_hsa003500.38079018
127Carbon metabolism_Homo sapiens_hsa012000.37499222
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37218987
129ErbB signaling pathway_Homo sapiens_hsa040120.36789674
130Non-small cell lung cancer_Homo sapiens_hsa052230.36296430
131Sphingolipid metabolism_Homo sapiens_hsa006000.35368457
132Herpes simplex infection_Homo sapiens_hsa051680.34389331
133Gap junction_Homo sapiens_hsa045400.33059890
134Epstein-Barr virus infection_Homo sapiens_hsa051690.31730345
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30527220

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