S100A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)9.42955794
2* leukocyte aggregation (GO:0070486)9.24635712
3* leukocyte migration involved in inflammatory response (GO:0002523)9.16501114
4killing of cells of other organism (GO:0031640)8.99805404
5disruption of cells of other organism (GO:0044364)8.99805404
6* defense response to fungus (GO:0050832)8.17286186
7* response to fungus (GO:0009620)6.99191232
8respiratory burst (GO:0045730)6.95784913
9neutrophil mediated immunity (GO:0002446)6.73525402
10detection of bacterium (GO:0016045)6.67383696
11neutrophil activation involved in immune response (GO:0002283)6.61898860
12detection of other organism (GO:0098543)6.14769498
13* sequestering of metal ion (GO:0051238)6.00977459
14innate immune response in mucosa (GO:0002227)5.91068317
15antibacterial humoral response (GO:0019731)5.80474954
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.71591830
17positive regulation by organism of defense response of other organism involved in symbiotic interact5.71591830
18modulation by symbiont of host immune response (GO:0052553)5.71591830
19positive regulation by symbiont of host defense response (GO:0052509)5.71591830
20modulation by symbiont of host defense response (GO:0052031)5.71591830
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.71591830
22modulation of growth of symbiont involved in interaction with host (GO:0044144)5.69399132
23regulation of growth of symbiont in host (GO:0044126)5.69399132
24negative regulation of growth of symbiont in host (GO:0044130)5.69399132
25negative regulation of growth of symbiont involved in interaction with host (GO:0044146)5.69399132
26phagosome maturation (GO:0090382)5.65420195
27hydrogen peroxide biosynthetic process (GO:0050665)5.60441967
28antimicrobial humoral response (GO:0019730)5.52802380
29cellular extravasation (GO:0045123)5.51230805
30reactive oxygen species biosynthetic process (GO:1903409)5.43354358
31superoxide anion generation (GO:0042554)5.41529036
32mucosal immune response (GO:0002385)5.40002329
33production of molecular mediator involved in inflammatory response (GO:0002532)5.38413043
34neutrophil activation (GO:0042119)5.38062276
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.36563263
36organ or tissue specific immune response (GO:0002251)5.11250389
37myeloid leukocyte mediated immunity (GO:0002444)5.08630771
38regulation of myeloid leukocyte mediated immunity (GO:0002886)5.04299652
39macrophage activation involved in immune response (GO:0002281)4.92977324
40cell killing (GO:0001906)4.92827182
41macrophage differentiation (GO:0030225)4.82593398
42granulocyte activation (GO:0036230)4.82394247
43regulation of leukocyte degranulation (GO:0043300)4.77705563
44leukotriene biosynthetic process (GO:0019370)4.71373943
45pentose-phosphate shunt (GO:0006098)4.67283593
46negative regulation of cell killing (GO:0031342)4.64509060
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.64509060
48detection of molecule of bacterial origin (GO:0032490)4.60069829
49antigen processing and presentation of endogenous antigen (GO:0019883)4.59074381
50leukotriene metabolic process (GO:0006691)4.58138517
51defense response to Gram-positive bacterium (GO:0050830)4.45137441
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.40831253
53negative regulation of phagocytosis (GO:0050765)4.36438377
54positive regulation of mast cell activation (GO:0033005)4.33943771
55regulation of regulated secretory pathway (GO:1903305)4.33864150
56negative regulation of interleukin-12 production (GO:0032695)4.33167649
57Arp2/3 complex-mediated actin nucleation (GO:0034314)4.26794107
58NADPH regeneration (GO:0006740)4.25148520
59* neutrophil chemotaxis (GO:0030593)4.23864997
60immunoglobulin mediated immune response (GO:0016064)4.22764673
61* chronic inflammatory response (GO:0002544)4.22107072
62negative regulation of lymphocyte mediated immunity (GO:0002707)4.15128167
63positive regulation of mast cell activation involved in immune response (GO:0033008)4.13548662
64positive regulation of mast cell degranulation (GO:0043306)4.13548662
65* neutrophil migration (GO:1990266)4.12235164
66microglial cell activation (GO:0001774)4.09848344
67positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.05004231
68regulation of interferon-beta biosynthetic process (GO:0045357)3.97922874
69regulation of mast cell degranulation (GO:0043304)3.96900409
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.94350043
71negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.90564165
72myeloid cell activation involved in immune response (GO:0002275)3.90449082
73macrophage activation (GO:0042116)3.86218299
74regulation of mast cell activation (GO:0033003)3.84328527
75regulation of gamma-delta T cell activation (GO:0046643)3.81775327
76leukocyte mediated cytotoxicity (GO:0001909)3.79109393
77cellular response to interleukin-6 (GO:0071354)3.78357478
78interaction with symbiont (GO:0051702)3.76461403
79modification by host of symbiont morphology or physiology (GO:0051851)3.75470957
80regulation of mast cell activation involved in immune response (GO:0033006)3.74490610
81negative regulation of leukocyte mediated immunity (GO:0002704)3.69741448
82positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.69054320
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.66976639
84regulation of B cell receptor signaling pathway (GO:0050855)3.64646105
85* granulocyte migration (GO:0097530)3.60401856
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.58458422
87positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.54705558
88response to host immune response (GO:0052572)3.54688613
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.54688613
90mast cell activation (GO:0045576)3.54644444
91* granulocyte chemotaxis (GO:0071621)3.53875456
92antigen processing and presentation via MHC class Ib (GO:0002475)3.46492051
93negative regulation of T cell mediated immunity (GO:0002710)3.46310045
94positive regulation of lamellipodium assembly (GO:0010592)3.44694722
95cellular response to zinc ion (GO:0071294)3.43118521
96negative regulation of myeloid cell apoptotic process (GO:0033033)3.42653154
97response to muramyl dipeptide (GO:0032495)3.39939845
98* defense response to bacterium (GO:0042742)3.38679244
99detection of external biotic stimulus (GO:0098581)3.33944997
100positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.33043257
101regulation of natural killer cell differentiation (GO:0032823)3.32600072
102negative regulation of interleukin-6 production (GO:0032715)3.31479441
103B cell mediated immunity (GO:0019724)3.29041667
104response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.27340852
105response to host (GO:0075136)3.27340852
106response to host defenses (GO:0052200)3.27340852
107positive regulation of leukocyte degranulation (GO:0043302)3.24920412
108protein localization to kinetochore (GO:0034501)3.24857309
109negative regulation of erythrocyte differentiation (GO:0045647)3.24825817
110defense response to Gram-negative bacterium (GO:0050829)3.23806008
111* leukocyte cell-cell adhesion (GO:0007159)3.22735257
112positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.22651655
113regulation of gamma-delta T cell differentiation (GO:0045586)3.14730016
114B cell receptor signaling pathway (GO:0050853)3.14212397
115negative regulation of T-helper cell differentiation (GO:0045623)3.13814629
116negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.13814629
117actin nucleation (GO:0045010)3.10984889
118regulation of T-helper 2 cell differentiation (GO:0045628)3.10779286
119myeloid leukocyte activation (GO:0002274)3.09880917
120defense response to protozoan (GO:0042832)3.09524484
121glucose catabolic process (GO:0006007)3.08285446
122positive regulation of cellular amide metabolic process (GO:0034250)3.08238182
123lipopolysaccharide-mediated signaling pathway (GO:0031663)3.02765827
124response to interleukin-6 (GO:0070741)3.02551759
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02517526
126* response to bacterium (GO:0009617)3.02460729
127regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.02438530
128response to interleukin-15 (GO:0070672)3.01938218
129lipoxygenase pathway (GO:0019372)3.01739258
130germinal center formation (GO:0002467)3.01508794
131leukocyte degranulation (GO:0043299)3.01498039
132type I interferon signaling pathway (GO:0060337)3.01117732
133cellular response to type I interferon (GO:0071357)3.01117732
134positive regulation of regulated secretory pathway (GO:1903307)3.00704513
135response to type I interferon (GO:0034340)2.97348620
136regulation of tolerance induction (GO:0002643)2.96647966
137positive regulation of B cell differentiation (GO:0045579)2.95067108
138interferon-gamma-mediated signaling pathway (GO:0060333)2.94466276
139negative regulation of innate immune response (GO:0045824)2.94188176
140adaptation of signaling pathway (GO:0023058)2.91955583
141regulation of phagocytosis (GO:0050764)2.91285544
142regulation of B cell differentiation (GO:0045577)2.90941044
143negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.90683235
144protein localization to chromosome, centromeric region (GO:0071459)2.84338266
145hepatocyte differentiation (GO:0070365)2.80449422
146positive regulation of osteoblast proliferation (GO:0033690)2.74718816
147detection of biotic stimulus (GO:0009595)2.71763770
148NADP metabolic process (GO:0006739)2.68733381
149pentose metabolic process (GO:0019321)2.68551238
150positive regulation of lamellipodium organization (GO:1902745)2.68328017
151positive regulation of toll-like receptor signaling pathway (GO:0034123)2.67832798
152positive regulation of gamma-delta T cell activation (GO:0046645)2.65275803
153regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.64538975
154killing of cells in other organism involved in symbiotic interaction (GO:0051883)11.8954711
155disruption of cells of other organism involved in symbiotic interaction (GO:0051818)11.8954711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.46520354
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.98891161
3MYB_21317192_ChIP-Seq_ERMYB_Mouse4.79337604
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.47785437
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.03725141
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.67953456
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.40003385
8* BRD4_27068464_Chip-Seq_AML-cells_Mouse3.35240380
9VDR_21846776_ChIP-Seq_THP-1_Human3.30630552
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.20564171
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18517649
12SCL_19346495_ChIP-Seq_HPC-7_Human2.89224785
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88380885
14* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.86689680
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.84799845
16* SPI1_23547873_ChIP-Seq_NB4_Human2.76879843
17VDR_24763502_ChIP-Seq_THP-1_Human2.56734652
18ESR1_15608294_ChIP-ChIP_MCF-7_Human2.51050142
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.50181202
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44158899
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41003894
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30709990
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.25114782
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.17431129
25SPI1_23127762_ChIP-Seq_K562_Human2.07644816
26MAF_26560356_Chip-Seq_TH1_Human2.06116528
27UTX_26944678_Chip-Seq_JUKART_Human2.06032441
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05364385
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03996940
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95189475
31MYB_26560356_Chip-Seq_TH2_Human1.91268976
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87694761
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87212878
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85080941
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82785443
36MYC_22102868_ChIP-Seq_BL_Human1.81683979
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81283489
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79501771
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.76320091
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73308179
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70589844
42TCF7_22412390_ChIP-Seq_EML_Mouse1.68636878
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67436038
44PU_27001747_Chip-Seq_BMDM_Mouse1.62921165
45GATA2_22383799_ChIP-Seq_G1ME_Mouse1.59038409
46VDR_24787735_ChIP-Seq_THP-1_Human1.57839512
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54889641
48MYB_26560356_Chip-Seq_TH1_Human1.54543320
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52069963
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48391673
51GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47438254
52PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45503915
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.45460435
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44547078
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43638396
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38755620
57GATA1_19941826_ChIP-Seq_K562_Human1.38463633
58RUNX_20019798_ChIP-Seq_JUKART_Human1.38213317
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36133704
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35409089
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33207982
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.32910636
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32391763
64AR_21909140_ChIP-Seq_LNCAP_Human1.30603040
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30216003
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29569476
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27028186
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26669776
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26639635
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26313811
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26283267
72SPI1_20517297_ChIP-Seq_HL60_Human1.25982338
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.25179625
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24511430
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21133845
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20223681
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19757301
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19009303
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18325828
80GATA2_19941826_ChIP-Seq_K562_Human1.15360462
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14489893
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13362311
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12716243
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.11121793
85GATA3_27048872_Chip-Seq_THYMUS_Human1.10942681
86ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07967158
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07250794
88GATA1_22025678_ChIP-Seq_K562_Human1.07246024
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.06734470
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06403968
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05632439
92* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05543018
93KDM2B_26808549_Chip-Seq_DND41_Human1.05185220
94* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04992899
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03578056
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01632234
97GATA3_26560356_Chip-Seq_TH2_Human1.01515642
98MAF_26560356_Chip-Seq_TH2_Human1.01007586
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99982369
100TP63_17297297_ChIP-ChIP_HaCaT_Human0.98225523
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96414848
102* BCL6_27268052_Chip-Seq_Bcells_Human0.95742647
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.94855779
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93683560
105LXR_22292898_ChIP-Seq_THP-1_Human0.93570171
106P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92166493
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91321819
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90870143
109RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89899915
110NCOR1_26117541_ChIP-Seq_K562_Human0.89212183
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87735790
112* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85181972
113CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83151528
114* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.81211752
115* BCOR_27268052_Chip-Seq_Bcells_Human0.80299373
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79462426
117ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76728124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.55748964
2MP0003436_decreased_susceptibility_to5.62742112
3MP0009785_altered_susceptibility_to4.45599183
4MP0003183_abnormal_peptide_metabolism4.16427552
5MP0002419_abnormal_innate_immunity3.59860478
6MP0001533_abnormal_skeleton_physiology2.92206506
7MP0009278_abnormal_bone_marrow2.87266040
8MP0005025_abnormal_response_to2.76930789
9MP0003656_abnormal_erythrocyte_physiolo2.74217702
10MP0006082_CNS_inflammation2.57773396
11MP0005464_abnormal_platelet_physiology2.38247114
12MP0008260_abnormal_autophagy2.36586123
13MP0001851_eye_inflammation2.30990538
14MP0005000_abnormal_immune_tolerance2.24914950
15MP0000465_gastrointestinal_hemorrhage2.14402649
16MP0002405_respiratory_system_inflammati2.13294110
17MP0000343_altered_response_to2.10713932
18MP0002420_abnormal_adaptive_immunity2.10425240
19MP0001819_abnormal_immune_cell2.08359253
20MP0003724_increased_susceptibility_to2.04584094
21MP0001835_abnormal_antigen_presentation1.95087678
22MP0002452_abnormal_antigen_presenting1.93113809
23MP0002148_abnormal_hypersensitivity_rea1.89173957
24MP0005397_hematopoietic_system_phenotyp1.84590266
25MP0001545_abnormal_hematopoietic_system1.84590266
26MP0001845_abnormal_inflammatory_respons1.83838310
27MP0000685_abnormal_immune_system1.81789350
28MP0001800_abnormal_humoral_immune1.79346460
29MP0003693_abnormal_embryo_hatching1.78342540
30MP0000858_altered_metastatic_potential1.78072666
31MP0001853_heart_inflammation1.77461856
32MP0003566_abnormal_cell_adhesion1.76044903
33MP0002723_abnormal_immune_serum1.72758759
34MP0003300_gastrointestinal_ulcer1.72307200
35MP0002132_abnormal_respiratory_system1.72008635
36MP0003763_abnormal_thymus_physiology1.69198973
37MP0004808_abnormal_hematopoietic_stem1.65515031
38MP0002398_abnormal_bone_marrow1.61183546
39MP0003172_abnormal_lysosome_physiology1.56590812
40MP0003075_altered_response_to1.53822738
41MP0001790_abnormal_immune_system1.52018646
42MP0005387_immune_system_phenotype1.52018646
43MP0000716_abnormal_immune_system1.50887688
44MP0004381_abnormal_hair_follicle1.48783633
45MP0000569_abnormal_digit_pigmentation1.47064367
46MP0004883_abnormal_blood_vessel1.41077781
47MP0002396_abnormal_hematopoietic_system1.39465986
48MP0005023_abnormal_wound_healing1.38789436
49MP0009333_abnormal_splenocyte_physiolog1.38623983
50MP0002837_dystrophic_cardiac_calcinosis1.35879116
51MP0003866_abnormal_defecation1.35860204
52MP0005451_abnormal_body_composition1.35397488
53MP0002429_abnormal_blood_cell1.34452581
54MP0002722_abnormal_immune_system1.33365719
55MP0005167_abnormal_blood-brain_barrier1.31464984
56MP0010155_abnormal_intestine_physiology1.29899667
57MP0009764_decreased_sensitivity_to1.29316662
58MP0002796_impaired_skin_barrier1.29293248
59MP0000689_abnormal_spleen_morphology1.26089462
60MP0003191_abnormal_cellular_cholesterol1.26017558
61MP0005058_abnormal_lysosome_morphology1.25060138
62MP0005671_abnormal_response_to1.23338377
63MP0002998_abnormal_bone_remodeling1.20717372
64MP0004510_myositis1.20591793
65MP0005076_abnormal_cell_differentiation1.19942529
66MP0001873_stomach_inflammation1.19835728
67MP0004947_skin_inflammation1.19029602
68MP0005390_skeleton_phenotype1.18824834
69MP0001663_abnormal_digestive_system1.16505628
70MP0008469_abnormal_protein_level1.13512589
71MP0003111_abnormal_nucleus_morphology1.12299472
72MP0005310_abnormal_salivary_gland1.12102767
73MP0001958_emphysema1.11567458
74MP0002166_altered_tumor_susceptibility1.10520608
75MP0006054_spinal_hemorrhage1.10020028
76MP0003186_abnormal_redox_activity1.07744427
77MP0002928_abnormal_bile_duct1.05523385
78MP0003690_abnormal_glial_cell1.05019552
79MP0001986_abnormal_taste_sensitivity1.02524918
80MP0002933_joint_inflammation1.00912586
81MP0005164_abnormal_response_to1.00130473
82MP0010094_abnormal_chromosome_stability0.98391431
83MP0005174_abnormal_tail_pigmentation0.97630813
84MP0000490_abnormal_crypts_of0.95250625
85MP0003448_altered_tumor_morphology0.93725623
86MP0010234_abnormal_vibrissa_follicle0.93152474
87MP0004782_abnormal_surfactant_physiolog0.90212277
88MP0010307_abnormal_tumor_latency0.90209314
89MP0003077_abnormal_cell_cycle0.89940037
90MP0002138_abnormal_hepatobiliary_system0.89524918
91MP0005083_abnormal_biliary_tract0.89263014
92MP0008004_abnormal_stomach_pH0.89211045
93MP0002277_abnormal_respiratory_mucosa0.86641065
94MP0003453_abnormal_keratinocyte_physiol0.86279066
95MP0000703_abnormal_thymus_morphology0.84869954
96MP0002133_abnormal_respiratory_system0.84308547
97MP0005388_respiratory_system_phenotype0.84308547
98MP0004264_abnormal_extraembryonic_tissu0.83747174
99MP0003828_pulmonary_edema0.80596643
100MP0002877_abnormal_melanocyte_morpholog0.77890193
101MP0005377_hearing/vestibular/ear_phenot0.77708664
102MP0003878_abnormal_ear_physiology0.77708664
103MP0002006_tumorigenesis0.74018613
104MP0003221_abnormal_cardiomyocyte_apopto0.72388236
105MP0009763_increased_sensitivity_to0.71713643
106MP0005381_digestive/alimentary_phenotyp0.70860822
107MP0002019_abnormal_tumor_incidence0.70589481
108MP0009931_abnormal_skin_appearance0.69117732
109MP0003795_abnormal_bone_structure0.67584326
110MP0005166_decreased_susceptibility_to0.67244688
111MP0008057_abnormal_DNA_replication0.66790146
112MP0005075_abnormal_melanosome_morpholog0.65987737
113MP0009765_abnormal_xenobiotic_induced0.65882829
114MP0004957_abnormal_blastocyst_morpholog0.65801877
115MP0000015_abnormal_ear_pigmentation0.65099771
116MP0002282_abnormal_trachea_morphology0.63991864
117MP0002089_abnormal_postnatal_growth/wei0.62244433
118MP0001764_abnormal_homeostasis0.61502620
119MP0000579_abnormal_nail_morphology0.61482462
120MP0005319_abnormal_enzyme/_coenzyme0.61470762
121MP0000249_abnormal_blood_vessel0.61461988
122MP0002060_abnormal_skin_morphology0.61340871
123MP0003045_fibrosis0.60894775
124MP0008874_decreased_physiological_sensi0.60658324
125MP0000920_abnormal_myelination0.59591551
126MP0003806_abnormal_nucleotide_metabolis0.59490408
127MP0001216_abnormal_epidermal_layer0.59395661
128MP0000604_amyloidosis0.58121849
129MP0005409_darkened_coat_color0.56339334
130MP0005501_abnormal_skin_physiology0.52087972

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)9.62420333
2Recurrent bacterial skin infections (HP:0005406)8.85260577
3Chronic obstructive pulmonary disease (HP:0006510)7.02499891
4Obstructive lung disease (HP:0006536)7.02499891
5Gingivitis (HP:0000230)6.24234339
6Mediastinal lymphadenopathy (HP:0100721)6.02825473
7Abnormality of macrophages (HP:0004311)5.76774567
8Recurrent skin infections (HP:0001581)5.02707762
9Cellulitis (HP:0100658)4.83370843
10Recurrent fungal infections (HP:0002841)4.72276148
11Urticaria (HP:0001025)4.70969105
12Optic neuritis (HP:0100653)4.65535219
13Retrobulbar optic neuritis (HP:0100654)4.65535219
14Papilledema (HP:0001085)4.30043628
15Stomatitis (HP:0010280)4.22422032
16Meningitis (HP:0001287)3.91157761
17Periodontitis (HP:0000704)3.19452406
18Episodic fever (HP:0001954)3.18084385
19Myositis (HP:0100614)3.05061381
20Recurrent pneumonia (HP:0006532)2.99228462
21Osteomyelitis (HP:0002754)2.97983335
22Anorexia (HP:0002039)2.89937300
23Sepsis (HP:0100806)2.85763899
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78602567
25Amyloidosis (HP:0011034)2.76912407
26Peritonitis (HP:0002586)2.74914284
27Pulmonary infiltrates (HP:0002113)2.73803390
28Abnormal platelet volume (HP:0011876)2.72774059
29Cutaneous photosensitivity (HP:0000992)2.70010176
30Skin ulcer (HP:0200042)2.58866073
31Hypochromic anemia (HP:0001931)2.58482902
32Chromsome breakage (HP:0040012)2.55852950
33Petechiae (HP:0000967)2.53444629
34Arterial thrombosis (HP:0004420)2.53053424
35Inflammation of the large intestine (HP:0002037)2.52085347
36Premature loss of primary teeth (HP:0006323)2.51601198
37Spontaneous hematomas (HP:0007420)2.50456924
38Hypochromic microcytic anemia (HP:0004840)2.49256082
39Duplicated collecting system (HP:0000081)2.49195065
40Reticulocytopenia (HP:0001896)2.46011325
41Hypergammaglobulinemia (HP:0010702)2.45166166
42IgM deficiency (HP:0002850)2.42992961
43Gastrointestinal inflammation (HP:0004386)2.42660364
44Increased mean platelet volume (HP:0011877)2.40475727
45Difficulty running (HP:0009046)2.40221720
46Abnormality of nail color (HP:0100643)2.39430044
47Recurrent cutaneous fungal infections (HP:0011370)2.35362618
48Chronic mucocutaneous candidiasis (HP:0002728)2.35362618
49Abnormality of DNA repair (HP:0003254)2.33773874
50Absent frontal sinuses (HP:0002688)2.29418366
51Epistaxis (HP:0000421)2.29361034
52Increased IgM level (HP:0003496)2.29097415
53Recurrent lower respiratory tract infections (HP:0002783)2.29080133
54Malnutrition (HP:0004395)2.25561859
55Eosinophilia (HP:0001880)2.24508488
56Leukocytosis (HP:0001974)2.24395946
57Recurrent viral infections (HP:0004429)2.22390074
58Cutaneous melanoma (HP:0012056)2.22322676
59Panhypogammaglobulinemia (HP:0003139)2.22308667
60Abnormality of T cell number (HP:0011839)2.21817461
61T lymphocytopenia (HP:0005403)2.21706654
62Hypermelanotic macule (HP:0001034)2.21523732
63Autoimmune thrombocytopenia (HP:0001973)2.21397870
64Increased serum ferritin (HP:0003281)2.21333091
65Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20731749
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.20304594
67Thick nail (HP:0001805)2.16098078
68Colitis (HP:0002583)2.15695625
69Abnormality of pyrimidine metabolism (HP:0004353)2.14432337
70Abnormality of T cells (HP:0002843)2.14231258
71Purpura (HP:0000979)2.13821137
72Hemoptysis (HP:0002105)2.08502940
73Keratoconjunctivitis sicca (HP:0001097)2.08055791
74Hepatosplenomegaly (HP:0001433)2.07400940
75Gingival bleeding (HP:0000225)2.07190509
76Abnormality of iron homeostasis (HP:0011031)2.06171715
77Abnormality of T cell physiology (HP:0011840)2.05030568
78Abnormality of glycolipid metabolism (HP:0010969)2.04450619
79Abnormality of liposaccharide metabolism (HP:0010968)2.04450619
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.04450619
81Abnormality of the peritoneum (HP:0002585)2.04104069
82Abnormality of B cell number (HP:0010975)2.03310022
83B lymphocytopenia (HP:0010976)2.03310022
84Oral leukoplakia (HP:0002745)2.01647300
85Abnormality of the renal collecting system (HP:0004742)2.01298012
86Granulocytopenia (HP:0001913)2.00729282
87Eczematoid dermatitis (HP:0000976)10.8319396
88Recurrent abscess formation (HP:0002722)10.0116028
89Skin rash (HP:0000988)1.99466429
90Interstitial pulmonary disease (HP:0006530)1.97771856
91Orchitis (HP:0100796)1.96426904
92Prolonged bleeding time (HP:0003010)1.95757595
93Microcytic anemia (HP:0001935)1.95635622
94Vasculitis (HP:0002633)1.95633589
95Muscle fiber splitting (HP:0003555)1.95141797
96Pustule (HP:0200039)1.95058978
97Abnormal foot bone ossification (HP:0010675)1.94477145
98Vacuolated lymphocytes (HP:0001922)1.94300067
99Chest pain (HP:0100749)1.93169952
100Abnormality of the endocardium (HP:0004306)1.93147778
101Spinal cord lesions (HP:0100561)1.90228898
102Syringomyelia (HP:0003396)1.90228898
103Keratitis (HP:0000491)1.89884331
104Lymphopenia (HP:0001888)1.89229443
105Poikiloderma (HP:0001029)1.88800383
106Systemic lupus erythematosus (HP:0002725)1.88506208
107Acne (HP:0001061)1.88067625
108Metaphyseal cupping (HP:0003021)1.87913518
109Keratoconjunctivitis (HP:0001096)1.87875323
110Vertigo (HP:0002321)1.87486350
111Loss of speech (HP:0002371)1.86286777
112Entropion (HP:0000621)1.85311524
113Short 4th metacarpal (HP:0010044)1.84329623
114Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84329623
115Pyloric stenosis (HP:0002021)1.82558915
116Abnormality of cells of the lymphoid lineage (HP:0012140)1.82250357
117Glomerulopathy (HP:0100820)1.81455796
118Cheilitis (HP:0100825)1.81387114
119Disinhibition (HP:0000734)1.80096010
120Recurrent sinusitis (HP:0011108)1.78282353
121Increased IgE level (HP:0003212)1.77565918
122Abnormal delayed hypersensitivity skin test (HP:0002963)1.72364041
123Tracheoesophageal fistula (HP:0002575)1.70035965
124Gangrene (HP:0100758)1.67414098
125Thickened calvaria (HP:0002684)1.67246069
126Spondylolisthesis (HP:0003302)1.66599482
127Increased cerebral lipofuscin (HP:0011813)1.66274458
128Delayed closure of the anterior fontanelle (HP:0001476)1.64661965
129Elevated erythrocyte sedimentation rate (HP:0003565)1.63719534
130Pulmonary embolism (HP:0002204)1.61432843
131Increased neuronal autofluorescent lipopigment (HP:0002074)1.59858958
132Flared metaphyses (HP:0003015)1.58580969
133Abnormality of the pleura (HP:0002103)1.57567814
134Persistence of primary teeth (HP:0006335)1.56903899
135Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.56712615
136Papilloma (HP:0012740)1.56477589
137Verrucae (HP:0200043)1.56477589
138Myelodysplasia (HP:0002863)1.56348197
139Neutropenia (HP:0001875)1.56188887
140Gastrointestinal infarctions (HP:0005244)1.54860952
141Thoracic kyphosis (HP:0002942)1.52845023
142Abnormality of eosinophils (HP:0001879)1.52631615
143Long clavicles (HP:0000890)1.51734896
144Encephalitis (HP:0002383)1.49596342
145Menorrhagia (HP:0000132)1.49577242
146Ectopic kidney (HP:0000086)1.49565505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK45.83578849
2TESK24.10296857
3EPHB13.37269809
4TESK13.18680605
5BLK2.99087939
6RIPK42.89446914
7BRSK22.65608846
8FES2.63227039
9GRK62.57217326
10CSK2.54239438
11WEE12.53312992
12MAP3K122.47810745
13TRPM72.45318657
14FGR2.44243575
15CLK12.39612098
16TNK22.33937169
17PRPF4B2.21504082
18BUB12.05467423
19MAP4K12.03792852
20ERBB31.91397970
21LIMK11.88245458
22ERN11.87263232
23MAP2K31.84376455
24STK101.76697310
25TTN1.73092116
26JAK31.71050603
27BRSK11.69245790
28BTK1.65347219
29PAK41.40822517
30IKBKE1.37688690
31HCK1.37537169
32SIK31.33816630
33MAP3K91.32227422
34CDC71.27241056
35NEK21.27144117
36TBK11.25675242
37MAP3K131.19520700
38STK41.18810360
39SYK1.15306216
40NEK11.14030144
41MAPK41.13977196
42ZAP701.13443296
43MARK21.07174113
44MAP2K41.03443254
45TEC1.02836820
46MAP3K21.02744050
47CAMKK21.01767105
48MAP2K61.01183441
49IRAK11.00400724
50LRRK20.98546257
51MARK30.98151487
52PRKD20.96966635
53TAOK20.95411776
54TRIB30.94283541
55MAP3K80.93497336
56TXK0.92198775
57IRAK20.86319703
58BMPR20.83213011
59IKBKB0.82868334
60MAP3K50.81342871
61CSF1R0.79501555
62PRKG20.79501222
63PIM10.77460697
64PTK60.74148002
65KDR0.73960241
66MAP3K110.73325797
67ALK0.71552817
68LYN0.70345760
69TGFBR20.68600705
70MAP3K70.67690219
71CDK190.67243112
72PRKCD0.67062263
73MAP3K140.65669640
74CCNB10.64162683
75RET0.64068499
76TAOK10.62402650
77RPS6KC10.62339067
78RPS6KL10.62339067
79RPS6KA60.61284796
80MAP3K30.59177048
81MAPK120.56532340
82CDK60.56218011
83EIF2AK30.55236771
84PTK2B0.55140942
85SMG10.53451137
86RPS6KA20.51727242
87CDC42BPA0.50254469
88MAPK70.49716403
89SGK30.49373701
90SIK10.48850726
91TLK10.47190555
92MYLK0.46208467
93ACVR1B0.45614264
94LCK0.45077297
95DYRK1B0.44955994
96PKN20.44893757
97PTK20.44490295
98RAF10.44066116
99FYN0.42968451
100HIPK20.41954131
101STK110.41842896
102TYK20.41554387
103TAOK30.40497411
104KSR10.40401288
105MAP3K10.39631639
106CAMKK10.39567760
107KSR20.39517945
108JAK20.39494036
109EPHA30.39047217
110MAPK110.38729233
111CDK40.38142143
112FGFR40.37863689
113MATK0.37782952
114DAPK20.35858395
115AURKB0.35702485
116MAPKAPK20.35348303
117VRK10.35241729
118PRKCQ0.34028494
119ITK0.33861803
120SIK20.33213888
121BMX0.32420776
122ILK0.31736057
123STK380.29627918
124PDPK10.28803153
125PRKCZ0.28412096
126PRKD10.27995665
127PDK10.27614633
128PLK10.27447814
129FGFR30.27302502
130KIT0.26549138
131PRKCH0.26347999
132GRK70.25825378
133SGK20.25599283
134MOS0.25531734
135MAP3K60.25118737
136CDK70.24846853
137EIF2AK20.24418469
138YES10.22450272
139DMPK0.20670622
140JAK10.19488254
141PIK3CG0.19468567
142ABL10.17509494

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051404.62026034
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.03205540
3Staphylococcus aureus infection_Homo sapiens_hsa051503.33257103
4Leukocyte transendothelial migration_Homo sapiens_hsa046703.28425655
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.67656425
6Osteoclast differentiation_Homo sapiens_hsa043802.48361325
7Tuberculosis_Homo sapiens_hsa051522.29527705
8Asthma_Homo sapiens_hsa053102.20295154
9Pentose phosphate pathway_Homo sapiens_hsa000301.99880037
10Phagosome_Homo sapiens_hsa041451.96585388
11Chemokine signaling pathway_Homo sapiens_hsa040621.95930167
12Shigellosis_Homo sapiens_hsa051311.92743123
13Pertussis_Homo sapiens_hsa051331.87987390
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.79598986
15Graft-versus-host disease_Homo sapiens_hsa053321.77679061
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.76117357
17Platelet activation_Homo sapiens_hsa046111.75093350
18Allograft rejection_Homo sapiens_hsa053301.73016945
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.66888052
20Autoimmune thyroid disease_Homo sapiens_hsa053201.60953453
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60186971
22B cell receptor signaling pathway_Homo sapiens_hsa046621.59637218
23Primary immunodeficiency_Homo sapiens_hsa053401.51406204
24Hematopoietic cell lineage_Homo sapiens_hsa046401.48262480
25DNA replication_Homo sapiens_hsa030301.41446964
26Histidine metabolism_Homo sapiens_hsa003401.37764619
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36820869
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.35171441
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34719687
30Salmonella infection_Homo sapiens_hsa051321.33935890
31Antigen processing and presentation_Homo sapiens_hsa046121.26680648
32Type I diabetes mellitus_Homo sapiens_hsa049401.23915244
33VEGF signaling pathway_Homo sapiens_hsa043701.23024300
34Caffeine metabolism_Homo sapiens_hsa002321.21684179
35Pancreatic cancer_Homo sapiens_hsa052121.17807857
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15841598
37Starch and sucrose metabolism_Homo sapiens_hsa005001.14719664
38Cell cycle_Homo sapiens_hsa041101.13415430
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12403913
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.07802471
41ABC transporters_Homo sapiens_hsa020101.07725203
42Legionellosis_Homo sapiens_hsa051341.06985581
43Other glycan degradation_Homo sapiens_hsa005111.03167960
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.02808238
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99252748
46Toxoplasmosis_Homo sapiens_hsa051450.98135348
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.96957437
48Systemic lupus erythematosus_Homo sapiens_hsa053220.94547254
49Hepatitis B_Homo sapiens_hsa051610.91656276
50Amoebiasis_Homo sapiens_hsa051460.89321489
51Viral myocarditis_Homo sapiens_hsa054160.88530804
52Malaria_Homo sapiens_hsa051440.87260854
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86313357
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85736774
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.84860409
56Apoptosis_Homo sapiens_hsa042100.82824775
57Glutathione metabolism_Homo sapiens_hsa004800.81878547
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81399569
59Insulin resistance_Homo sapiens_hsa049310.80841805
60TNF signaling pathway_Homo sapiens_hsa046680.79909738
61Renal cell carcinoma_Homo sapiens_hsa052110.78941936
62GnRH signaling pathway_Homo sapiens_hsa049120.78716369
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78040849
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77584290
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77409909
66Non-small cell lung cancer_Homo sapiens_hsa052230.76198456
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75308274
68Prolactin signaling pathway_Homo sapiens_hsa049170.73608564
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73251901
70Arachidonic acid metabolism_Homo sapiens_hsa005900.72525884
71Chronic myeloid leukemia_Homo sapiens_hsa052200.72383437
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72281174
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69691488
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68402947
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67654753
76Acute myeloid leukemia_Homo sapiens_hsa052210.66885540
77p53 signaling pathway_Homo sapiens_hsa041150.66787301
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65934506
79Notch signaling pathway_Homo sapiens_hsa043300.65318090
80Lysosome_Homo sapiens_hsa041420.65209786
81Bladder cancer_Homo sapiens_hsa052190.64163709
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.64023777
83Influenza A_Homo sapiens_hsa051640.62758111
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62445547
85Type II diabetes mellitus_Homo sapiens_hsa049300.61807716
86Salivary secretion_Homo sapiens_hsa049700.61547222
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.61293539
88Fructose and mannose metabolism_Homo sapiens_hsa000510.61088366
89Choline metabolism in cancer_Homo sapiens_hsa052310.61064233
90Herpes simplex infection_Homo sapiens_hsa051680.60254131
91Endocytosis_Homo sapiens_hsa041440.59896757
92Measles_Homo sapiens_hsa051620.58854415
93Complement and coagulation cascades_Homo sapiens_hsa046100.57827750
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57415784
95Viral carcinogenesis_Homo sapiens_hsa052030.56480116
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56337596
97Dorso-ventral axis formation_Homo sapiens_hsa043200.55231819
98Rap1 signaling pathway_Homo sapiens_hsa040150.53672480
99Regulation of autophagy_Homo sapiens_hsa041400.53546848
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53520055
101African trypanosomiasis_Homo sapiens_hsa051430.53160637
102Endometrial cancer_Homo sapiens_hsa052130.52636363
103Rheumatoid arthritis_Homo sapiens_hsa053230.52580810
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52159974
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.51820981
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.51791674
107Galactose metabolism_Homo sapiens_hsa000520.51363164
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51063984
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49893661
110Hepatitis C_Homo sapiens_hsa051600.49302761
111FoxO signaling pathway_Homo sapiens_hsa040680.47895100
112Collecting duct acid secretion_Homo sapiens_hsa049660.46177234
113MAPK signaling pathway_Homo sapiens_hsa040100.43482240
114Base excision repair_Homo sapiens_hsa034100.42240358
115Oocyte meiosis_Homo sapiens_hsa041140.41917583
116mTOR signaling pathway_Homo sapiens_hsa041500.41820152
117Fanconi anemia pathway_Homo sapiens_hsa034600.38057038
118Epstein-Barr virus infection_Homo sapiens_hsa051690.37672058
119T cell receptor signaling pathway_Homo sapiens_hsa046600.37579074
120Glioma_Homo sapiens_hsa052140.36241936
121Insulin signaling pathway_Homo sapiens_hsa049100.36053888
122Inositol phosphate metabolism_Homo sapiens_hsa005620.34883962
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34151938
124Non-homologous end-joining_Homo sapiens_hsa034500.32333504
125MicroRNAs in cancer_Homo sapiens_hsa052060.31699291
126Estrogen signaling pathway_Homo sapiens_hsa049150.30556771
127Proteoglycans in cancer_Homo sapiens_hsa052050.29462650
128HIF-1 signaling pathway_Homo sapiens_hsa040660.29250516

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