S100B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.37223692
2cellular potassium ion homeostasis (GO:0030007)6.15353549
3long-chain fatty acid biosynthetic process (GO:0042759)5.80704960
4myelination (GO:0042552)5.73232433
5amyloid precursor protein metabolic process (GO:0042982)5.72600642
6cholesterol biosynthetic process (GO:0006695)5.65786536
7ensheathment of neurons (GO:0007272)5.65245931
8axon ensheathment (GO:0008366)5.65245931
9sodium ion export (GO:0071436)5.57388039
10L-amino acid import (GO:0043092)5.41917466
11postsynaptic membrane organization (GO:0001941)5.38536020
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.28054100
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.12190841
14sterol biosynthetic process (GO:0016126)5.09750436
15synaptic vesicle exocytosis (GO:0016079)4.98975918
16glutamate secretion (GO:0014047)4.96155986
17regulation of lipoprotein metabolic process (GO:0050746)4.79785004
18negative regulation of protein localization to cell surface (GO:2000009)4.74585785
19myelin maintenance (GO:0043217)4.70708253
20negative regulation of neurotransmitter transport (GO:0051589)4.68503710
21potassium ion homeostasis (GO:0055075)4.62420363
22establishment of mitochondrion localization (GO:0051654)4.57118076
23long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.55349649
24amino acid import (GO:0043090)4.50222596
25long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.47454185
26cerebellar granule cell differentiation (GO:0021707)4.39447707
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.35381369
28ionotropic glutamate receptor signaling pathway (GO:0035235)4.30176486
29isoprenoid biosynthetic process (GO:0008299)4.30089619
30regulation of short-term neuronal synaptic plasticity (GO:0048172)4.23750413
31neuronal ion channel clustering (GO:0045161)4.20837540
32regulation of collateral sprouting (GO:0048670)4.12543757
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.05419110
34regulation of synaptic vesicle transport (GO:1902803)4.02111948
35auditory behavior (GO:0031223)3.95523819
36fatty-acyl-CoA biosynthetic process (GO:0046949)3.94052569
37neurotransmitter uptake (GO:0001504)3.92850438
38neurotransmitter secretion (GO:0007269)3.89715826
39cellular sodium ion homeostasis (GO:0006883)3.88433308
40vocalization behavior (GO:0071625)3.86847983
41neurotransmitter-gated ion channel clustering (GO:0072578)3.85136366
42fatty-acyl-CoA metabolic process (GO:0035337)3.81729153
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.81342424
44neuronal action potential propagation (GO:0019227)3.76997891
45synaptic transmission, glutamatergic (GO:0035249)3.75281637
46very long-chain fatty acid metabolic process (GO:0000038)3.74870354
47negative regulation of neurotransmitter secretion (GO:0046929)3.68855469
48detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.63965107
49detection of temperature stimulus involved in sensory perception (GO:0050961)3.63965107
50regulation of synapse structural plasticity (GO:0051823)3.60524362
51exploration behavior (GO:0035640)3.59820983
52import into cell (GO:0098657)3.58964321
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.57449844
54* regulation of neuronal synaptic plasticity (GO:0048168)3.56018221
55eye photoreceptor cell differentiation (GO:0001754)3.51892242
56photoreceptor cell differentiation (GO:0046530)3.51892242
57positive regulation of oligodendrocyte differentiation (GO:0048714)3.48344891
58regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.47864343
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44354876
60response to auditory stimulus (GO:0010996)3.43715516
61axon development (GO:0061564)3.41267352
62cell communication by electrical coupling (GO:0010644)3.40942852
63glycerophospholipid catabolic process (GO:0046475)3.40120318
64glutamate receptor signaling pathway (GO:0007215)3.40066685
65response to redox state (GO:0051775)3.38396766
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.38320296
67positive regulation of dendritic spine development (GO:0060999)3.36024135
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36011543
69regulation of glutamate receptor signaling pathway (GO:1900449)3.35326793
70substantia nigra development (GO:0021762)3.35132959
71neurotransmitter transport (GO:0006836)3.34635745
72regulation of long-term neuronal synaptic plasticity (GO:0048169)3.32329732
73response to lipoprotein particle (GO:0055094)3.31152778
74neuron-neuron synaptic transmission (GO:0007270)3.28999884
75gamma-aminobutyric acid transport (GO:0015812)3.27629002
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26601597
77cerebellar Purkinje cell layer development (GO:0021680)3.26578719
78regulation of neurotransmitter levels (GO:0001505)3.22736244
79mechanosensory behavior (GO:0007638)3.19120836
80amyloid precursor protein catabolic process (GO:0042987)3.19104613
81neuromuscular process controlling balance (GO:0050885)3.18820768
82positive regulation of synapse maturation (GO:0090129)3.15989899
83gamma-aminobutyric acid signaling pathway (GO:0007214)3.15688633
84thioester biosynthetic process (GO:0035384)3.14864761
85acyl-CoA biosynthetic process (GO:0071616)3.14864761
86regulation of neurotransmitter secretion (GO:0046928)3.13176287
87detection of temperature stimulus (GO:0016048)3.12828677
88regulation of excitatory postsynaptic membrane potential (GO:0060079)3.11793151
89regulation of neurotransmitter transport (GO:0051588)3.11258242
90protein palmitoylation (GO:0018345)3.10930027
91protein localization to synapse (GO:0035418)3.10855832
92magnesium ion transport (GO:0015693)3.09121996
93protein neddylation (GO:0045116)3.08188507
94negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.07796228
95adult walking behavior (GO:0007628)3.06400142
96positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02167346
97* regulation of synaptic plasticity (GO:0048167)3.00204717
98presynaptic membrane organization (GO:0097090)2.99943544
99creatine metabolic process (GO:0006600)2.98720619
100regulation of synaptic transmission, glutamatergic (GO:0051966)2.98547617
101regulation of dendritic spine development (GO:0060998)2.97347464
102positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.97032989
103C4-dicarboxylate transport (GO:0015740)2.96298637
104negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.94821776
105regulation of ARF protein signal transduction (GO:0032012)2.93546384
106peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.92217782
107synaptic vesicle endocytosis (GO:0048488)2.91755538
108cerebellar Purkinje cell differentiation (GO:0021702)2.91443422
109synaptic vesicle maturation (GO:0016188)2.90975581
110L-glutamate transport (GO:0015813)2.90909283
111long-term memory (GO:0007616)2.89475371
112myelination in peripheral nervous system (GO:0022011)2.88449042
113peripheral nervous system axon ensheathment (GO:0032292)2.88449042
114positive regulation of membrane potential (GO:0045838)2.88322180
115extracellular matrix assembly (GO:0085029)2.88288460
116acidic amino acid transport (GO:0015800)2.87580974
117membrane tubulation (GO:0097320)2.87578501
118astrocyte development (GO:0014002)2.86471405
119regulation of amyloid precursor protein catabolic process (GO:1902991)2.85348434
120regulation of postsynaptic membrane potential (GO:0060078)2.84772410
121tissue regeneration (GO:0042246)2.84053569
122membrane assembly (GO:0071709)2.81701013
123glycine transport (GO:0015816)2.81132171
124detection of calcium ion (GO:0005513)2.81047321
125neuron cell-cell adhesion (GO:0007158)2.79399934
126dendritic spine morphogenesis (GO:0060997)2.78875975
127membrane depolarization during action potential (GO:0086010)2.77200153
128oligodendrocyte differentiation (GO:0048709)2.76081461
129* long-term synaptic potentiation (GO:0060291)2.75942852
130* response to methylmercury (GO:0051597)2.75532855
131negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75010376
132regulation of cardiac muscle cell contraction (GO:0086004)2.74587141
133* regulation of synaptic transmission (GO:0050804)2.74164241
134negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.73721470
135regulation of dendritic spine morphogenesis (GO:0061001)2.73141813
136positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.71127456
137neuron remodeling (GO:0016322)2.70392972
138regulation of sensory perception (GO:0051931)2.69847356
139regulation of sensory perception of pain (GO:0051930)2.69847356
140regulation of cytokine production involved in inflammatory response (GO:1900015)2.68034873
141negative regulation of axonogenesis (GO:0050771)2.67396322
142mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67019208
143iron coordination entity transport (GO:1901678)2.66683137
144apical protein localization (GO:0045176)2.65921706
145nerve growth factor signaling pathway (GO:0038180)2.65692559
146coenzyme catabolic process (GO:0009109)2.64243537
147positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.63554988
148alcohol biosynthetic process (GO:0046165)2.59041343
149glycosylceramide metabolic process (GO:0006677)2.58923810
150transmission of nerve impulse (GO:0019226)2.57538879
151asymmetric protein localization (GO:0008105)2.56492783
152presynaptic membrane assembly (GO:0097105)2.55930415
153cranial nerve development (GO:0021545)2.53326358
154locomotory exploration behavior (GO:0035641)2.49430392
155peptidyl-tyrosine autophosphorylation (GO:0038083)2.48739354
156estrogen biosynthetic process (GO:0006703)2.46777101
157potassium ion import (GO:0010107)2.45447204
158response to dietary excess (GO:0002021)2.44938635
159regulation of beta-amyloid formation (GO:1902003)2.44502747
160regulation of neurotransmitter uptake (GO:0051580)2.43250797
161neuron recognition (GO:0008038)2.42369555
162regulation of voltage-gated calcium channel activity (GO:1901385)2.41175444
163peripheral nervous system development (GO:0007422)2.40222967
164negative regulation of axon extension (GO:0030517)2.38438363
165negative regulation of chemokine production (GO:0032682)2.36985548
166regulation of synaptic vesicle exocytosis (GO:2000300)2.36718370
167cerebral cortex radially oriented cell migration (GO:0021799)2.36249517
168limb bud formation (GO:0060174)2.35318176
169neuron projection regeneration (GO:0031102)2.33895823
170central nervous system myelination (GO:0022010)10.5320533
171axon ensheathment in central nervous system (GO:0032291)10.5320533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.64653654
2GBX2_23144817_ChIP-Seq_PC3_Human2.73531882
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56598076
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52419127
5SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.50810603
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42762628
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20787577
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18883710
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14717171
10AR_21572438_ChIP-Seq_LNCaP_Human2.14425559
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12013330
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12013330
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08852179
14OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.08220312
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07786265
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06141256
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05762313
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03974009
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.02048453
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.95575357
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.93152885
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86778289
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84398131
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82307308
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80290636
26TAF15_26573619_Chip-Seq_HEK293_Human1.77142786
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.72930547
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70904574
29ER_23166858_ChIP-Seq_MCF-7_Human1.63658346
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61597858
31DROSHA_22980978_ChIP-Seq_HELA_Human1.60057715
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51281108
33REST_21632747_ChIP-Seq_MESCs_Mouse1.45334009
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.44212413
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41853292
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.41670839
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40649337
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40092787
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39112086
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37884413
41TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36545456
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36533398
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36279263
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36033272
45P300_19829295_ChIP-Seq_ESCs_Human1.35913557
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.34060770
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33871110
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.33833111
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32880337
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30128419
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28890003
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.28604741
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28062696
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.27516153
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26969477
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25820500
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25820500
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.23022883
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22681092
60STAT3_23295773_ChIP-Seq_U87_Human1.22428809
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22075938
62SMAD4_21799915_ChIP-Seq_A2780_Human1.20686010
63STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20265629
64* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17271163
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17146298
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16384475
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15798314
68VDR_22108803_ChIP-Seq_LS180_Human1.15199687
69AR_19668381_ChIP-Seq_PC3_Human1.14994775
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14807837
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.14689039
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13663421
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13318969
74TP53_16413492_ChIP-PET_HCT116_Human1.13279919
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.12723209
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.11838808
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11585585
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10645236
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.10598141
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10325684
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10035247
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09831032
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09479047
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09107547
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08904200
86CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08189637
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.07912270
88KDM2B_26808549_Chip-Seq_K562_Human1.07065309
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.05971324
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05434827
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05111144
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04526487
93SOX2_19829295_ChIP-Seq_ESCs_Human1.03707665
94NANOG_19829295_ChIP-Seq_ESCs_Human1.03707665
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02408001
96OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02251203
97TCF4_23295773_ChIP-Seq_U87_Human1.01983209
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01000643
99SMAD3_21741376_ChIP-Seq_ESCs_Human1.00965318
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.00963871
101TRIM28_21343339_ChIP-Seq_HEK293_Human1.00917823
102P300_18555785_Chip-Seq_ESCs_Mouse1.00486442
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00384750
104EOMES_21245162_ChIP-Seq_HESCs_Human0.99993212
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99845524
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98981495
107ERG_21242973_ChIP-ChIP_JURKAT_Human0.98254351
108E2F1_18555785_Chip-Seq_ESCs_Mouse0.98172033
109STAT3_18555785_Chip-Seq_ESCs_Mouse0.97814569
110SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97739278
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97069175
112FUS_26573619_Chip-Seq_HEK293_Human0.96730063
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95663796
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94591229
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93703420
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93349555
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93285460
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92740522
119RING1B_27294783_Chip-Seq_NPCs_Mouse0.92130535
120P53_22387025_ChIP-Seq_ESCs_Mouse0.91647225
121IGF1R_20145208_ChIP-Seq_DFB_Human0.91515363
122MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90396382
123RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90053612
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.89551097
125ARNT_22903824_ChIP-Seq_MCF-7_Human0.89241415
126RUNX2_22187159_ChIP-Seq_PCA_Human0.89204031
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88880297
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88800875
129AR_25329375_ChIP-Seq_VCAP_Human0.88782198
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.88005402
131KLF4_18555785_Chip-Seq_ESCs_Mouse0.87833672
132HTT_18923047_ChIP-ChIP_STHdh_Human0.87645407
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.86894271
134ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86350745
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84093805
136RNF2_27304074_Chip-Seq_NSC_Mouse0.83646211
137ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83615169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.73028132
2MP0003880_abnormal_central_pattern3.61383482
3MP0003690_abnormal_glial_cell3.05495170
4MP0004270_analgesia3.04375172
5MP0003329_amyloid_beta_deposits3.04194551
6MP0002272_abnormal_nervous_system2.77956941
7MP0005423_abnormal_somatic_nervous2.60348302
8MP0004859_abnormal_synaptic_plasticity2.58743150
9MP0004742_abnormal_vestibular_system2.56704537
10MP0003950_abnormal_plasma_membrane2.51724958
11MP0001486_abnormal_startle_reflex2.51061426
12MP0002064_seizures2.45806792
13MP0001905_abnormal_dopamine_level2.40949832
14MP0004142_abnormal_muscle_tone2.36332488
15MP0004885_abnormal_endolymph2.30753027
16MP0003136_yellow_coat_color2.23463784
17MP0001984_abnormal_olfaction2.21714832
18MP0003635_abnormal_synaptic_transmissio2.20507847
19MP0003634_abnormal_glial_cell2.19306338
20MP0001529_abnormal_vocalization2.18620396
21MP0009046_muscle_twitch2.14972513
22MP0005171_absent_coat_pigmentation2.10973948
23MP0001485_abnormal_pinna_reflex2.03615351
24MP0002734_abnormal_mechanical_nocicepti2.02877502
25MP0000778_abnormal_nervous_system2.01750564
26MP0009745_abnormal_behavioral_response2.00015562
27MP0003633_abnormal_nervous_system1.93427015
28MP0003632_abnormal_nervous_system1.83795947
29MP0003631_nervous_system_phenotype1.83293593
30MP0002063_abnormal_learning/memory/cond1.82889318
31MP0004134_abnormal_chest_morphology1.81192972
32MP0001968_abnormal_touch/_nociception1.80667269
33MP0005409_darkened_coat_color1.80343499
34MP0003879_abnormal_hair_cell1.76605248
35MP0001440_abnormal_grooming_behavior1.74367656
36MP0002572_abnormal_emotion/affect_behav1.73826705
37MP0008569_lethality_at_weaning1.73665333
38MP0005410_abnormal_fertilization1.68088340
39MP0002229_neurodegeneration1.67717454
40MP0000569_abnormal_digit_pigmentation1.67424120
41MP0005167_abnormal_blood-brain_barrier1.67130848
42MP0002736_abnormal_nociception_after1.65461575
43MP0000604_amyloidosis1.63338885
44MP0002067_abnormal_sensory_capabilities1.58623116
45MP0002735_abnormal_chemical_nociception1.57644948
46MP0000955_abnormal_spinal_cord1.53122761
47MP0002733_abnormal_thermal_nociception1.51246545
48* MP0001970_abnormal_pain_threshold1.50457419
49MP0002638_abnormal_pupillary_reflex1.44851190
50MP0005623_abnormal_meninges_morphology1.43748558
51MP0004043_abnormal_pH_regulation1.42802277
52MP0003656_abnormal_erythrocyte_physiolo1.42704568
53MP0002882_abnormal_neuron_morphology1.38600029
54MP0000462_abnormal_digestive_system1.36644684
55MP0005551_abnormal_eye_electrophysiolog1.32869939
56MP0004145_abnormal_muscle_electrophysio1.31787202
57MP0002066_abnormal_motor_capabilities/c1.31536032
58MP0010678_abnormal_skin_adnexa1.29164995
59MP0001963_abnormal_hearing_physiology1.25145007
60MP0008260_abnormal_autophagy1.25068809
61MP0003806_abnormal_nucleotide_metabolis1.19391963
62MP0004858_abnormal_nervous_system1.17045595
63MP0002909_abnormal_adrenal_gland1.11299391
64MP0001299_abnormal_eye_distance/1.10375538
65MP0006276_abnormal_autonomic_nervous1.10327035
66MP0002752_abnormal_somatic_nervous1.09588503
67MP0005386_behavior/neurological_phenoty1.08174092
68MP0004924_abnormal_behavior1.08174092
69MP0000747_muscle_weakness1.03232738
70MP0003787_abnormal_imprinting1.03176806
71MP0003195_calcinosis1.02488168
72MP0001177_atelectasis1.02094455
73MP0002184_abnormal_innervation1.01918205
74MP0001501_abnormal_sleep_pattern1.01704359
75MP0002557_abnormal_social/conspecific_i0.98877102
76MP0001986_abnormal_taste_sensitivity0.98118791
77MP0000372_irregular_coat_pigmentation0.97124656
78MP0002822_catalepsy0.96902208
79MP0000383_abnormal_hair_follicle0.96424381
80MP0005174_abnormal_tail_pigmentation0.95959783
81MP0002295_abnormal_pulmonary_circulatio0.94354295
82MP0005058_abnormal_lysosome_morphology0.93651792
83MP0002653_abnormal_ependyma_morphology0.92369807
84MP0004381_abnormal_hair_follicle0.88019427
85MP0002095_abnormal_skin_pigmentation0.87816896
86MP0005646_abnormal_pituitary_gland0.87792504
87MP0005195_abnormal_posterior_eye0.83257360
88MP0002152_abnormal_brain_morphology0.82411707
89MP0000749_muscle_degeneration0.82148281
90MP0000015_abnormal_ear_pigmentation0.80408916
91MP0003938_abnormal_ear_development0.78838987
92MP0003075_altered_response_to0.78819155
93MP0004811_abnormal_neuron_physiology0.78739423
94MP0005253_abnormal_eye_physiology0.78362169
95MP0009250_abnormal_appendicular_skeleto0.77012656
96MP0008874_decreased_physiological_sensi0.75760099
97MP0000026_abnormal_inner_ear0.75475031
98MP0001851_eye_inflammation0.73722071
99MP0004036_abnormal_muscle_relaxation0.73616401
100MP0004130_abnormal_muscle_cell0.73026887
101MP0000647_abnormal_sebaceous_gland0.72976363
102MP0003172_abnormal_lysosome_physiology0.72541249
103MP0000762_abnormal_tongue_morphology0.71395280
104MP0005535_abnormal_body_temperature0.70813334
105MP0005388_respiratory_system_phenotype0.68658547
106MP0002133_abnormal_respiratory_system0.68658547
107MP0004215_abnormal_myocardial_fiber0.65447640
108MP0009780_abnormal_chondrocyte_physiolo0.65316212
109MP0003137_abnormal_impulse_conducting0.63811712
110MP0005645_abnormal_hypothalamus_physiol0.63672011
111MP0002090_abnormal_vision0.63161475
112MP0003122_maternal_imprinting0.62681321
113MP0004147_increased_porphyrin_level0.60473319
114MP0002069_abnormal_eating/drinking_beha0.60448047
115MP0001502_abnormal_circadian_rhythm0.60141244
116MP0005670_abnormal_white_adipose0.58767711
117MP0001943_abnormal_respiration0.58610003
118MP0000579_abnormal_nail_morphology0.58457065
119MP0005166_decreased_susceptibility_to0.56518869
120MP0005595_abnormal_vascular_smooth0.56418624
121MP0005075_abnormal_melanosome_morpholog0.48242028
122MP0010386_abnormal_urinary_bladder0.47601867
123MP0003011_delayed_dark_adaptation0.46328618
124MP0000566_synostosis0.44681405
125MP0001958_emphysema0.43572736

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.49174119
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.49174119
3Neurofibrillary tangles (HP:0002185)6.32788403
4Abnormality of the corticospinal tract (HP:0002492)5.10882648
5Termporal pattern (HP:0011008)4.99511486
6Insidious onset (HP:0003587)4.99511486
7Diplopia (HP:0000651)4.87381787
8Supranuclear gaze palsy (HP:0000605)4.59452202
9Cerebral inclusion bodies (HP:0100314)4.56161102
10Febrile seizures (HP:0002373)4.48718171
11Atonic seizures (HP:0010819)4.41526393
12Peripheral hypomyelination (HP:0007182)4.22923417
13Hemiplegia (HP:0002301)4.11465950
14Parakeratosis (HP:0001036)4.03246097
15Retinal dysplasia (HP:0007973)3.84320477
16Action tremor (HP:0002345)3.78190321
17Onion bulb formation (HP:0003383)3.65732060
18Myokymia (HP:0002411)3.60791306
19Segmental peripheral demyelination/remyelination (HP:0003481)3.59614047
20Abnormal eating behavior (HP:0100738)3.58801075
21Truncal ataxia (HP:0002078)3.57181370
22Generalized tonic-clonic seizures (HP:0002069)3.56239318
23Ankle clonus (HP:0011448)3.41347961
24Scanning speech (HP:0002168)3.40621476
25Abnormality of glycolysis (HP:0004366)3.37242077
26Increased serum pyruvate (HP:0003542)3.37242077
27Spastic gait (HP:0002064)3.33195685
28Dysmetria (HP:0001310)3.24035539
29Intention tremor (HP:0002080)3.19940764
30Absence seizures (HP:0002121)3.13515419
31Dialeptic seizures (HP:0011146)3.01928928
32Slow saccadic eye movements (HP:0000514)3.00253686
33Pheochromocytoma (HP:0002666)2.96394732
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.94734383
35Leukodystrophy (HP:0002415)2.93914812
36Postural instability (HP:0002172)2.93214347
37White forelock (HP:0002211)2.92948062
38Focal motor seizures (HP:0011153)2.86629167
39Mutism (HP:0002300)2.75629992
40Limb dystonia (HP:0002451)2.71145976
41Ulnar claw (HP:0001178)2.66209638
42Cerebral hypomyelination (HP:0006808)2.63934210
43Neuroendocrine neoplasm (HP:0100634)2.63737995
44Visual hallucinations (HP:0002367)2.61615532
45Patchy hypopigmentation of hair (HP:0011365)2.60551993
46Torticollis (HP:0000473)2.59690415
47Obstructive sleep apnea (HP:0002870)2.58623618
48Sensory axonal neuropathy (HP:0003390)2.56702755
49Urinary urgency (HP:0000012)2.56507715
50Cerebral hemorrhage (HP:0001342)2.54744580
51Increased circulating renin level (HP:0000848)2.51980309
52Tetraplegia (HP:0002445)2.51605894
53Akinesia (HP:0002304)2.51308984
54Heterochromia iridis (HP:0001100)2.48578088
55Axonal loss (HP:0003447)2.48060651
56Acute necrotizing encephalopathy (HP:0006965)2.42698801
57Lower limb muscle weakness (HP:0007340)2.42095931
58Abnormal auditory evoked potentials (HP:0006958)2.42003308
59Blue irides (HP:0000635)2.41106867
60Delusions (HP:0000746)2.39240075
61Rigidity (HP:0002063)2.35873099
62Metabolic alkalosis (HP:0200114)2.29389524
63Depression (HP:0000716)2.28668451
64Ocular albinism (HP:0001107)2.28279971
65Abnormality of the periventricular white matter (HP:0002518)2.27402850
66Focal dystonia (HP:0004373)2.26787480
67Bradykinesia (HP:0002067)2.26145711
68Morphological abnormality of the inner ear (HP:0011390)2.25474214
69Foot dorsiflexor weakness (HP:0009027)2.25178878
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24806402
71Aplasia of the phalanges of the hand (HP:0009802)2.24583245
72Aplasia involving bones of the extremities (HP:0009825)2.24583245
73Aplasia involving bones of the upper limbs (HP:0009823)2.24583245
74Polyphagia (HP:0002591)2.24002010
75Type II lissencephaly (HP:0007260)2.23602516
76Hypoplastic pelvis (HP:0008839)2.23536114
77Congenital ichthyosiform erythroderma (HP:0007431)2.23529428
78Hammertoe (HP:0001765)2.23373413
79Acute encephalopathy (HP:0006846)2.22334050
80Insomnia (HP:0100785)2.20774808
81Abnormal ciliary motility (HP:0012262)2.18990124
82Status epilepticus (HP:0002133)2.17374379
83Impaired vibration sensation in the lower limbs (HP:0002166)2.15988305
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.14843775
85Papilledema (HP:0001085)2.14392959
86Clonus (HP:0002169)2.14163702
87Postural tremor (HP:0002174)2.13411681
88Iris hypopigmentation (HP:0007730)2.13215129
89Anomalous pulmonary venous return (HP:0010772)2.12902845
90Progressive macrocephaly (HP:0004481)2.12395276
91Steppage gait (HP:0003376)2.12240277
92Dysdiadochokinesis (HP:0002075)2.11307135
93Methylmalonic acidemia (HP:0002912)2.09916050
94Abnormal respiratory motile cilium physiology (HP:0012261)2.09190427
95Apathy (HP:0000741)2.08922976
96Sleep apnea (HP:0010535)2.08673325
97Morphological abnormality of the pyramidal tract (HP:0002062)2.08075311
98Stridor (HP:0010307)2.07802579
99Decreased lacrimation (HP:0000633)2.07135186
100Choreoathetosis (HP:0001266)2.07131970
101Rapidly progressive (HP:0003678)2.05497394
102Craniofacial dystonia (HP:0012179)2.04963537
103Hemiparesis (HP:0001269)2.03945938
104Abnormality of the foot musculature (HP:0001436)2.03540808
105Spastic tetraparesis (HP:0001285)2.01068906
106Hypomagnesemia (HP:0002917)2.00070414
107Annular pancreas (HP:0001734)2.00031179
108Abnormal mitochondria in muscle tissue (HP:0008316)1.98587174
109Global brain atrophy (HP:0002283)1.98308355
110Megalencephaly (HP:0001355)1.98133345
111Decreased motor nerve conduction velocity (HP:0003431)1.98112869
112Epileptiform EEG discharges (HP:0011182)1.96150113
113Progressive cerebellar ataxia (HP:0002073)1.95837162
114Anteriorly placed anus (HP:0001545)1.95331297
115Alacrima (HP:0000522)1.95063987
116Hypokalemic alkalosis (HP:0001949)1.94863798
117Poor eye contact (HP:0000817)1.93400002
118Hypoplasia of the iris (HP:0007676)1.92838242
119CNS hypomyelination (HP:0003429)1.92564995
120Turricephaly (HP:0000262)1.89800371
121Absent septum pellucidum (HP:0001331)1.89455932
122Clumsiness (HP:0002312)1.88986019
123Abnormality of the middle phalanges of the toes (HP:0010183)1.88396438
124Neuronal loss in central nervous system (HP:0002529)1.87186365
125Epileptic encephalopathy (HP:0200134)1.87183888
126Diminished motivation (HP:0000745)1.87144940
127Gait ataxia (HP:0002066)1.86937991
128Focal seizures (HP:0007359)1.84461695
129Abnormality of saccadic eye movements (HP:0000570)1.82665459
130Gaze-evoked nystagmus (HP:0000640)1.80612743
131Partial agenesis of the corpus callosum (HP:0001338)1.80610757
132Split foot (HP:0001839)1.80118290
133Autoamputation (HP:0001218)1.79662178
134Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.79587480
135Urinary bladder sphincter dysfunction (HP:0002839)1.78787965
136Urinary incontinence (HP:0000020)1.78062571
137Spastic paraparesis (HP:0002313)1.76883658
138Bowel incontinence (HP:0002607)1.76553039
139Abnormality of the pulmonary veins (HP:0011718)1.76466091
140Hepatosplenomegaly (HP:0001433)1.76090531
141Distal sensory impairment (HP:0002936)1.74866573
142Anxiety (HP:0000739)1.74544147
143Coronal craniosynostosis (HP:0004440)1.73970025
144Loss of speech (HP:0002371)1.72688317
145Spastic paraplegia (HP:0001258)1.72684295
146Hypophosphatemic rickets (HP:0004912)1.72591516
147Paraplegia (HP:0010550)1.70971357
148Abnormality of binocular vision (HP:0011514)1.70603930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.58364541
2EPHB14.83348616
3MAPKAPK54.52392195
4OXSR13.06062454
5PBK2.98391970
6WNK42.61945153
7DAPK22.38996495
8UHMK12.33886167
9WNK12.21103904
10PNCK2.04149775
11PKN11.98985889
12TYRO31.84540784
13CAMKK11.83049354
14MST41.75284810
15SGK4941.74870100
16SGK2231.74870100
17CASK1.70390384
18RIPK11.70068558
19TNIK1.69900843
20NTRK11.61800762
21FGFR21.58370524
22TESK21.58301313
23LIMK11.46727018
24BCR1.45174200
25FES1.38196524
26MARK11.37903342
27ROCK21.29610319
28SGK21.23353185
29MUSK1.22237871
30NTRK31.17779051
31MINK11.15574205
32CAMK2B1.09212337
33MKNK11.08737935
34DYRK21.07710569
35CAMK11.06757568
36PAK61.05267103
37PHKG11.04835921
38PHKG21.04835921
39MAPK151.04065904
40MAP3K41.02570456
41MAP2K71.02126311
42PINK11.01865103
43RIPK41.01411968
44CLK11.00854823
45MAPK131.00541086
46CDK190.99493007
47MET0.99007472
48IRAK20.98799276
49MARK20.98413677
50CSNK1G30.96917844
51CAMK2D0.96650793
52MAP3K20.95843105
53NTRK20.90354108
54CAMK2A0.89967649
55CSNK1A1L0.89561739
56SGK30.89510738
57SGK10.89174618
58TNK20.88116244
59PRKD10.86672365
60NEK60.86120641
61KSR20.84772332
62MAP3K130.82970197
63FGR0.82752717
64MAPK100.82668574
65CDK50.82040066
66CAMK2G0.77258605
67CSNK1G20.77037277
68PRKCQ0.76090681
69EPHA40.75234138
70GRK50.74682599
71CSNK1G10.73796791
72PRKCE0.73009212
73GRK70.68162581
74DDR20.65977007
75CDK140.64815010
76PRKD30.64769412
77LMTK20.63204370
78IRAK10.63056079
79ALK0.62275317
80LATS20.61994213
81PDK20.61462007
82MAP2K20.60935002
83RPS6KA50.59460030
84RPS6KA30.59132525
85PAK30.58885992
86PLK20.58275633
87GSK3A0.57947934
88MAP3K90.57851197
89STK110.57289008
90PDPK10.57178920
91CDK150.57089127
92ERBB20.56530490
93PTK2B0.56303601
94FYN0.55346201
95CAMK1G0.53889208
96CDK180.53611056
97DAPK10.53329523
98DAPK30.53277827
99PRKCZ0.52529477
100STK380.51938459
101KSR10.49690352
102CDK11A0.49592797
103PRKG10.49450499
104PRKACB0.47005967
105ARAF0.46985393
106ADRBK20.46040158
107SIK20.45395822
108MAPK40.44617119
109PRKACA0.44328924
110MAPK120.43887619
111CSNK1A10.43391714
112DYRK1A0.42354758
113RAF10.42217523
114PRPF4B0.41497193
115PRKCA0.40596284
116CAMK40.40549071
117MOS0.40271040
118RET0.40202387
119PDGFRB0.39652610
120EPHA30.38147013
121MAP2K40.37153063
122SRC0.36356899
123PRKCG0.35129903
124CAMKK20.34789694
125PIK3CA0.34714634
126MAPK70.34110468
127PRKCH0.33044932
128CSNK1D0.32460009
129PDK10.32223224
130ROCK10.29892718
131INSR0.28974617
132BMPR20.28540152

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.84917833
2Steroid biosynthesis_Homo sapiens_hsa001004.93721218
3Fatty acid elongation_Homo sapiens_hsa000624.56133147
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.53107108
5Ether lipid metabolism_Homo sapiens_hsa005653.09565966
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.94862205
7Oxidative phosphorylation_Homo sapiens_hsa001902.01954893
8Nitrogen metabolism_Homo sapiens_hsa009101.91066457
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80970956
10Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68772006
11Vitamin B6 metabolism_Homo sapiens_hsa007501.63412712
12Parkinsons disease_Homo sapiens_hsa050121.58872128
13Glutamatergic synapse_Homo sapiens_hsa047241.57522704
14Butanoate metabolism_Homo sapiens_hsa006501.52207763
15GABAergic synapse_Homo sapiens_hsa047271.50097888
16Alzheimers disease_Homo sapiens_hsa050101.49815476
17Linoleic acid metabolism_Homo sapiens_hsa005911.44922748
18Sphingolipid metabolism_Homo sapiens_hsa006001.44045310
19Histidine metabolism_Homo sapiens_hsa003401.43096100
20Sulfur metabolism_Homo sapiens_hsa009201.42263645
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38585414
22Protein export_Homo sapiens_hsa030601.35910969
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34782698
24Estrogen signaling pathway_Homo sapiens_hsa049151.28701806
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27779086
26Bile secretion_Homo sapiens_hsa049761.26173410
27Serotonergic synapse_Homo sapiens_hsa047261.24389028
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23421610
29Long-term depression_Homo sapiens_hsa047301.23023598
30beta-Alanine metabolism_Homo sapiens_hsa004101.17424018
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13634421
32Synaptic vesicle cycle_Homo sapiens_hsa047211.08765721
33Circadian entrainment_Homo sapiens_hsa047131.08445620
34Morphine addiction_Homo sapiens_hsa050321.05913107
35Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05234009
36Nicotine addiction_Homo sapiens_hsa050331.03371221
37Thyroid hormone synthesis_Homo sapiens_hsa049181.01914131
38Melanogenesis_Homo sapiens_hsa049161.01837342
39Collecting duct acid secretion_Homo sapiens_hsa049661.01450078
40cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99983281
41Gastric acid secretion_Homo sapiens_hsa049710.99869955
42Axon guidance_Homo sapiens_hsa043600.97198697
43Glioma_Homo sapiens_hsa052140.95754835
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94423313
45Cholinergic synapse_Homo sapiens_hsa047250.94421230
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94293397
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91409381
48Dopaminergic synapse_Homo sapiens_hsa047280.91257345
49Fatty acid metabolism_Homo sapiens_hsa012120.90828899
50Salivary secretion_Homo sapiens_hsa049700.90788557
51Huntingtons disease_Homo sapiens_hsa050160.87086770
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.86928469
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86446034
54Cardiac muscle contraction_Homo sapiens_hsa042600.84842737
55Propanoate metabolism_Homo sapiens_hsa006400.83730722
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80605729
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78493385
58Renal cell carcinoma_Homo sapiens_hsa052110.78435706
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.75779354
60PPAR signaling pathway_Homo sapiens_hsa033200.74027208
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73853625
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73490566
63Taste transduction_Homo sapiens_hsa047420.70245940
64Arginine and proline metabolism_Homo sapiens_hsa003300.69353223
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69334158
66Rap1 signaling pathway_Homo sapiens_hsa040150.69289365
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69247092
68Vibrio cholerae infection_Homo sapiens_hsa051100.67996239
69Cocaine addiction_Homo sapiens_hsa050300.67606433
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65641731
71ErbB signaling pathway_Homo sapiens_hsa040120.64304319
72Dorso-ventral axis formation_Homo sapiens_hsa043200.63578829
73Renin secretion_Homo sapiens_hsa049240.62802685
74Ovarian steroidogenesis_Homo sapiens_hsa049130.61903137
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61459537
76Mineral absorption_Homo sapiens_hsa049780.61392193
77Pyruvate metabolism_Homo sapiens_hsa006200.60219738
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59708693
79Inositol phosphate metabolism_Homo sapiens_hsa005620.59189355
80Pancreatic secretion_Homo sapiens_hsa049720.58096499
81Long-term potentiation_Homo sapiens_hsa047200.56661004
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.56415165
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.55985856
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.55558790
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55551340
86Prion diseases_Homo sapiens_hsa050200.55259427
87Circadian rhythm_Homo sapiens_hsa047100.55049057
88Amphetamine addiction_Homo sapiens_hsa050310.54779729
89Olfactory transduction_Homo sapiens_hsa047400.54777497
90Ras signaling pathway_Homo sapiens_hsa040140.54284231
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53731798
92Oocyte meiosis_Homo sapiens_hsa041140.53378218
93Gap junction_Homo sapiens_hsa045400.53278798
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50023091
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49380631
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49339002
97Fatty acid biosynthesis_Homo sapiens_hsa000610.48178798
98MAPK signaling pathway_Homo sapiens_hsa040100.47397441
99Insulin secretion_Homo sapiens_hsa049110.47125817
100Arachidonic acid metabolism_Homo sapiens_hsa005900.46961326
101Phototransduction_Homo sapiens_hsa047440.46473405
102Tight junction_Homo sapiens_hsa045300.45837258
103Glutathione metabolism_Homo sapiens_hsa004800.45328420
104VEGF signaling pathway_Homo sapiens_hsa043700.44418365
105Peroxisome_Homo sapiens_hsa041460.43677900
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43523554
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42682985
108Dilated cardiomyopathy_Homo sapiens_hsa054140.42149342
109Choline metabolism in cancer_Homo sapiens_hsa052310.41327105
110GnRH signaling pathway_Homo sapiens_hsa049120.39113777
111Phagosome_Homo sapiens_hsa041450.38657480
112Rheumatoid arthritis_Homo sapiens_hsa053230.38202046
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37889566
114Type II diabetes mellitus_Homo sapiens_hsa049300.37503874
115Endocytosis_Homo sapiens_hsa041440.37033967
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36559118
117cAMP signaling pathway_Homo sapiens_hsa040240.36266508
118ABC transporters_Homo sapiens_hsa020100.35457708
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34845469
120Metabolic pathways_Homo sapiens_hsa011000.34516004
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33619417
122Folate biosynthesis_Homo sapiens_hsa007900.33371097
123Glucagon signaling pathway_Homo sapiens_hsa049220.31013150
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30933626
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30916717
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30902672
127Oxytocin signaling pathway_Homo sapiens_hsa049210.30789953
128Calcium signaling pathway_Homo sapiens_hsa040200.30167955
129Glycerolipid metabolism_Homo sapiens_hsa005610.29900264
130Lysosome_Homo sapiens_hsa041420.29624773
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29222823
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27958957

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »